APPLIED BIOSCIENCE INTERNATIONAL INC
SC 13G, 2000-05-26
TESTING LABORATORIES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  ------------

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                               (Amendment No. __)

                             Orchid Biosciences Inc.
                     ---------------------------------------
                                (Name of issuer)

                                 Common Stock
                     ---------------------------------------
                         (Title of class of securities)

                                    68571p100
                     ---------------------------------------
                                 (CUSIP number)

                                  May 17, 2000
                     ---------------------------------------
             (Date of Event which requires filing of this Statement)

     Check the appropriate box to designate the rule pursuant to which this
                               schedule is filed:

                                /_/ Rule 13d-1 (b)
                               /X/  Rule 13d-1 (c)
                               /_/  Rule 13d-1 (d)

<PAGE>



- ---------------------------------
      CUSIP No. 68571p 100                     13G
- ---------------------------------


- -------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Bank A.G.
- -------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                (a) /_/
                                                                         (b) /_/

- -------- -----------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
- ---------------------------- ------ --------------------------------------------
NUMBER OF                    5      SOLE VOTING POWER
SHARES                              0
BENEFICIALLY                 ------ --------------------------------------------
OWNED BY                            SHARED VOTING POWER
EACH                         6      1,730,000
REPORTING                    ------ --------------------------------------------
PERSON                              SOLE DISPOSITIVE POWER
WITH                         7      7,190
                             ------ --------------------------------------------
                                    SHARED DISPOSITIVE POWER
                             8      1,730,000
- -------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,730,000*
- -------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                      /_/
- -------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         5.4%**
- -------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, BK, CO
- -------- -----------------------------------------------------------------------



- --------------------------

*    Included in this  figure are the  securities  reported  by  Deutsche  Fonds
     Holding GmbH on the following cover page.

**   Included in this  percentage are the  percentage of securities  reported by
     Deutsche Fonds Holding GmbH on the following cover page.

<PAGE>


- ---------------------------------
      CUSIP No. 68571p 100                     13G
- ---------------------------------


- -------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Fonds Holding GmbH
- -------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                (a) /_/
                                                                         (b) /_/

- -------- -----------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
- ---------------------------- ------ --------------------------------------------
NUMBER OF                    5      SOLE VOTING POWER
SHARES                              0
BENEFICIALLY                 ------ --------------------------------------------
OWNED BY                            SHARED VOTING POWER
EACH                         6      1,730,000
REPORTING                    ------ --------------------------------------------
PERSON                              SOLE DISPOSITIVE POWER
WITH                         7      0
                             ------ --------------------------------------------
                                    SHARED DISPOSITIVE POWER
                             8      1,730,000
- -------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,730,000*
- -------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                      /_/
- -------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         5.4%
- -------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC
- -------- -----------------------------------------------------------------------


<PAGE>


Item 1(a). Name of Issuer:

           Orchid Biosciences Inc. (the "Issuer")

Item 1(b). Address of Issuer's Principal Executive Offices:

           The  address  of the  Issuer's  principal  executive  offices  is 303
College Road East, Princeton, New Jersey 08540, USA.

Item 2(a). Name of Person Filing:

           This  statement  is filed on behalf of Deutsche  Bank AG ("DBAG") and
Deutsche Fonds Holding GmbH ("DWS Group" and, together with DBAG, the "Reporting
Persons").

Item 2(b). Address of Principal Business Office or, if none, Residence:

           The principal place of business of DBAG is Taunusanlage  12, D-60325,
Frankfurt am Main, Federal Republic of Germany.

           The principal place of business of DWS Group is Gruneburgweg 113-115,
60323 Frankfurt, Federal Republic of Germany.


Item 2(c). Citizenship:

           The  citizenship  of  the  Reporting  Persons  is  set  forth  on the
applicable cover page.

Item 2(d). Title of Class of Securities:

           The title of the securities is Common Stock (the "Common Stock").

Item 2(e). CUSIP Number:

           The CUSIP number of the Common Stock is set forth on each cover page.

Item 3.    If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or
           (c), check whether the person filing is a:

           (a)    |_|  Broker or dealer registered under section 15 of the Act;

           (b)    |_|  Bank as defined in section 3(a)(6) of the Act;

           (c)    |_|  Insurance  Company as defined in section 3(a)(19) of the
                       Act;

           (d)    |_|  Investment  Company  registered  under  section  8 of the
                       Investment Company Act of 1940;

           (e)    |_|  An investment  adviser  in accordance  with  Rule  13d-1
                       (b)(1)(ii)(E);

           (f)    |_|  An employee benefit plan, or endowment fund in accordance
                       with Rule 13d-1 (b)(1)(ii)(F);

           (g)    |_|  A parent holding company or control person in accordance
                       with Rule 13d-1 (b)(1)(ii)(G);

           (h)    |_|  A savings  association as defined in section 3(b) of the
                       Federal Deposit Insurance Act;

           (i)    |_|  A church plan that is excluded  from the  definition  of
                       an  investment  company  under  section  3(c)(14) of the
                       Investment Company Act of 1940;

           (j)    |_|  Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

           If this  statement  is filed  pursuant to Rule 13d-1 (c),  check this
box. |X|

Item 4.  Ownership.

         (a) Amount beneficially owned:

          Each of the  Reporting  Persons owns the amount of the Common Stock as
     set forth on the applicable cover page.

         (b) Percent of class:

          Each of the Reporting  Persons owns the percentage of the Common Stock
     as set forth on the applicable cover page.

         (c) Number of shares as to which such person has:

             (i)  sole power to vote or to direct the vote:

                  Each of the Reporting  Persons has  the  sole power to vote or
               direct  the  vote  of  the  Common  Stock  as  set  forth  on the
               applicable cover page.

             (ii) shared power to vote or to direct the vote:

                  Each  of  the  Reporting  Persons has the shared power to vote
               or  direct  the  vote of the  Common  Stock  as set  forth on the
               applicable cover page.

             (iii) sole power to dispose or to direct the disposition of:

                  Each of the Reporting  Persons  has  the sole power to dispose
               or direct the disposition of the Common Stock as set forth on the
               applicable cover page.

             (iv) shared power to dispose or to direct the disposition of:

                  Each of the  Reporting  Persons  has  the  shared   power   to
               dispose or direct  the  disposition  of the  Common  Stock as set
               forth on the applicable cover page.

Item 5.   Ownership of Five Percent or Less of a Class.

          Not applicable.

Item 6.   Ownership of More than Five Percent on Behalf of Another Person.

          Investment  management  clients of each of the Reporting  Persons have
the ultimate  right to any dividends from Common Stock and the proceeds from the
sale of Common Stock.

Item 7.   Identification and Classification of the Subsidiary Which Acquired the
          Security Being Reported on by the Parent Holding Company.

          The  following  are  subsidiaries  of DBAG and/or DWS Group which hold
Common Stock included in the figures on the cover pages:  Deutsche  Gesellschaft
fur  Wertpapiersparen mbH, Deutsche  Vermogensbildungsgesellschaft  mbH and DWS
Investment Management S.A. Luxemburg.

Item 8.   Identification and Classification of Members of the Group.

          Not applicable.

Item 9.   Notice of Dissolution of Group.

          Not applicable.

Item 10.  Certification.

          By  signing  below I certify  that,  to the best of my  knowledge  and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.



<PAGE>


                                   SIGNATURE
                                   ---------


          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated:  May 25, 2000



                                     DEUTSCHE BANK AG



                                     By: /s/ Dr. Dieter Eisele
                                         -------------------------------
                                         Name:   Dr. Dieter Eisele
                                         Title:  Group Head of Compliance



                                     By: /s/ Dr. Rainer Grimberg
                                         --------------------------------
                                         Name:   Dr. Rainer Grimberg
                                         Title:  Vice President


<PAGE>

                                                                       EXHIBIT 1



                     Consent of Deutsche Fonds Holding GmbH
                     --------------------------------------

          The undersigned agrees that the Schedule 13G executed by Deutsche Bank
AG to which  this  statement  is  attached  as an  exhibit is filed on behalf of
Deutsche Bank AG and Deutsche Fonds Holding GmbH pursuant to Rule 13d-1(k)(1) of
the Securities Exchange Act of 1934.

Dated:  May 25, 2000



                                          Deutsche Fonds Holding GmbH



                                          By: /s/ Michael Sistenich
                                              ----------------------------------
                                              Name:   Michael Sistenich
                                              Title:  Fund Manager



                                          By: /s/ Ralf Ring
                                              ----------------------------------
                                               Name:   Ralf Ring
                                               Title:  Head of Compliance (DWS)





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