AGOURON PHARMACEUTICALS INC
8-A12G/A, 1996-12-20
PHARMACEUTICAL PREPARATIONS
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                    SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C.  20549

                                FORM 8-A/A

                             Amendment No. 2


            FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                  PURSUANT TO SECTION 12(b) OR (g) OF THE
                     SECURITIES EXCHANGE ACT OF 1934



                     Agouron Pharmaceuticals, Inc.   
                (Exact name of registrant as specified
                          in its charter)


                  California                   33-0061928    
           (State of incorporation          (I.R.S. Employer
              or organization)              Identification No.)


      10350 North Torrey Pines Road, La Jolla, California 92037
           (Address of principal executive offices) (Zip Code)


Securities to be registered pursuant to Section 12(b) of the Act:


       Title of each class            Name of each exchange on which
       to be so registered            each class is to be registered

             None                                   N/A


If this Form relates to the registration of a class of debt securities and 
is effective upon filing pursuant to General  Instruction A.(c)(1), please 
check the following box.  / /

If this Form relates to the registration of a class of debt securities and 
is to become effective simultaneously with the effectiveness of a concurrent 
registration statement under the Securities Act of 1933 pursuant to General 
Instruction A.(c)(2),  please check the following box.  / / 

Securities to be registered pursuant to Section 12(g) of the Act:

Preferred Stock Purchase Rights (the "Rights")

<PAGE>

     The Registrant hereby amends the following items of its Registration 
Statement on Form 8-A dated November 7, 1996, as follows:


Item 1.      Description of Registrant's Securities to be Registered.

     Pursuant to the requirement of the California Secretary of State, 
Exhibit A (Certificate of Determination, Preferences and Rights of Series B 
Participating Preferred Stock) to the Rights Agreement attached to the Form 
8-A filed with the Securities and Exchange Commission on November 8, 1996, 
was amended and restated to make certain non-substantive revisions and to 
delete certain rights by holders of shares of Series B Participating 
Preferred Stock relating to the election of a Director in the event of any 
default in the payment of six (6) quarterly dividends.


Item 2.     Exhibits.

   1          Amendment No. 1, dated as of November 27, 1996, to Rights 
              Agreement dated as of November 7, 1996, between Agouron 
              Pharmaceuticals, Inc. and Chase Mellon Shareholder Services, 
              L.L.C., which includes as Exhibit A the Certificate of 
              Determination, Preferences and Rights of Series B Participating 
              Preferred Stock as filed with the California Secretary of State 
              on November 20, 1996.  


                                     -2-
<PAGE>

                                   SIGNATURE

     Pursuant to the requirements of Section 12 of the Securities Exchange 
Act of 1934, as amended, the Registrant has duly caused this Amendment No. 
1 to be signed on its behalf by the undersigned, thereto duly authorized.

     Dated:  December 20, 1996.

                                  AGOURON PHARMACEUTICALS, INC.



                                  By /s/ PETER JOHNSON
                                     ------------------------------ 
                                             Peter Johnson
                                             President and
                                       Chief Executive Officer

                                     -3-
<PAGE>

                                EXHIBIT INDEX


Exhibit                                                              Page

1         Amendment No. 1, dated as of November 27, 1996, to 
          Rights Agreement dated as of November 7, 1996, between 
          Agouron Pharmaceuticals, Inc. and Chase Mellon 
          Shareholder Services, L.L.C., which includes as 
          Exhibit A the Certificate of Determination, Preferences 
          and Rights of Series B Participating Preferred Stock as 
          filed with the California Secretary of State on November 
          20, 1996.  


                                     -4-
<PAGE>







                                                 EXHIBIT 1

                  AMENDMENT NO. 1 TO RIGHTS AGREEMENT


          THIS AMENDMENT NO. 1, dated as of November 27, 
1996, is entered into between AGOURON PHARMACEUTICALS, INC., 
a California corporation (the "Company"), and CHASE MELLON 
SHAREHOLDER SERVICES, L.L.C., a New Jersey limited liability 
company (the "Rights Agent"),

                         W I T N E S S E T H:

          Whereas  the Company and the Rights Agent have 
entered into that certain Rights Agreement dated as of 
November 7, 1996 (the "Rights Agreement"); and 

          Whereas the Company has determined to amend the 
Rights Agreement by amending and restating the Certificate of 
Determination, Preferences and Rights of Series B 
Participating Preferred Stock attached as Exhibit A thereto; 
and 

          Whereas the Company has determined that the 
amendment represented hereby is in compliance with Section 
27 of the Rights Agreement;:

          N o w,  T h e r e f o r e,  in consideration of 
the premises and the mutual agreements herein set forth, the 
parties hereby agree as follows:

          Section 1.  Amendment.  Exhibit A to the Rights 
Agreement, the Certificate of Determination, Preferences 
and Rights of Series B Participating Preferred Stock, is 
hereby amended and restated to read in full as set forth on 
Exhibit A hereto.

          Section 2.  Counterparts.  This Amendment No. 1 may 
be executed in any number of counterparts and each of such 
counterparts shall for all purposes be deemed to be an

                             -1-
<PAGE>

original, but all such counterparts together shall constitute 
one and the same instrument.

          IN WITNESS WHEREOF,  the parties hereto have caused 
this Amendment No. 1 to be duly executed as of the date and 
year first above written.

AGOURON PHARMACEUTICALS, INC.



By /s/ Peter Johnson
   -------------------------------
           Peter Johnson
           President and
      Chief Executive Officer


CHASE MELLON SHAREHOLDER 
SERVICES, L.L.C.



By /s/ Ronald Lug
    -----------------------------
           Ronald Lug
         Vice President


                             -2-
<PAGE>

                         EXHIBIT A

               CERTIFICATE OF DETERMINATION,

                   PREFERENCES AND RIGHTS

         OF SERIES B PARTICIPATING PREFERRED STOCK

                            OF

             AGOURON PHARMACEUTICALS, INC.


     We, Peter Johnson, President, and Gary E. Friedman, 
Secretary, of Agouron Pharmaceuticals, Inc., a corporation 
organized and existing under the General Corporation Law of 
the State of California, DO HEREBY CERTIFY:

     1.  That pursuant to the authority conferred upon the 
Board of Directors by the Articles of Incorporation of the 
Corporation, the said Board of Directors on November 7, 1996 
adopted the following resolution creating a series of two 
thousand (2,000) shares of Preferred Stock designated as 
Series B Participating Preferred Stock:

     "RESOLVED, that pursuant to the authority vested in the 
Board of Directors of the Corporation in accordance with the 
provisions of its Articles of Incorporation, a series of 
Preferred Stock of the Corporation be and it hereby is 
created, and that the designation and amount thereof and the 
powers, preferences and relative, participating, optional and 
other special rights of the shares of such series, and the 
qualifications, limitations or restrictions thereof are as 
follows:

     Section 1.  Designation and Amount.  The shares of such 
series shall be designated as "Series B Participating 
Preferred Stock," no par value, and the number of shares 
constituting such series shall be two thousand (2,000).  Such 
number of shares may be increased or decreased by resolution 
of the Board of Directors; provided, that no decrease shall 
reduce the number of shares of Series B Participating 
Preferred Stock to a number less than that of the shares then 
outstanding plus the number of shares issuable upon exercise 
of outstanding rights, options or  warrants or upon conversion 
of outstanding securities issued by the Corporation.

     Section 2.  Dividends and Distributions.

     (a)  Subject to the prior and superior rights of the  
holders of any shares of any series of Preferred Stock 
ranking prior and superior to the shares of Series B 

                             -A-1-
<PAGE>

Participating Preferred Stock with respect to dividends, the 
holders of shares of Series B Participating Preferred Stock 
in preference to the holders of shares of Common Stock, no 
par value (the "Common Stock"), of the Corporation and any 
other junior stock, shall be entitled to receive, when, as 
and if declared by the Board of Directors out of funds 
legally available for the purpose, quarterly dividends 
payable in cash on the first day of March, June, 
September and December in each year (each such date being 
referred to herein as a "Quarterly Dividend Payment Date"), 
commencing on the first Quarterly Dividend Payment Date after 
the first issuance of a share or fraction of a share of 
Series B Participating Preferred Stock in an amount per share 
(rounded to the nearest cent) equal to the greater of 
(i) $100, or (ii) subject to the provision for adjustment 
hereinafter set forth, 10,000 times the aggregate per share 
amount of all cash dividends, and 10,000 times the aggregate 
per share amount (payable in kind) of all non-cash dividends 
or other distributions other than a dividend payable in 
shares of Common Stock or a subdivision of the outstanding 
shares of Common Stock (by reclassification or otherwise), 
declared on the Common Stock, since the immediately preceding 
Quarterly Dividend Payment Date, or, with respect to the 
first Quarterly Dividend Payment Date, since the first 
issuance of any share or fraction of a share of Series B 
Participating Preferred Stock.  In the event the Corporation 
shall at any time after the close of business on November 7, 
1996 (the "Rights Declaration Date") (A) declare any dividend 
on Common Stock payable in shares of Common Stock, 
(B) subdivide the outstanding Common Stock, or (C) combine 
the outstanding Common Stock into a smaller number of shares, 
by reclassification or otherwise, then in each such case the 
amount to which holders of shares of Series B Participating 
Preferred Stock were entitled immediately prior to such event 
under clause (ii) of the preceding sentence shall be adjusted 
by multiplying such amount by a fraction the numerator of 
which is the number of shares of Common Stock outstanding 
immediately after such event and the denominator of which is 
the number of shares of Common Stock that were outstanding 
immediately prior to such event.

     (b)  The Corporation shall declare a dividend or 
distribution on the Series B Participating Preferred Stock as 
provided in paragraph (a) above immediately after it declares 
a dividend or distribution on the Common Stock (other than a 
dividend payable in shares of Common Stock); provided that, 
in the event no dividend or distribution shall have been 
declared on the Common Stock during the period between any 
Quarterly Dividend Payment Date and the next subsequent 
Quarterly Dividend Payment Date, a dividend of $100 per share 
on the Series B Participating Preferred Stock shall 
nevertheless be payable on such subsequent Quarterly Dividend 
Payment Date.

                             -A-2-
<PAGE>

     (c)  Dividends shall begin to accrue and be cumulative 
on outstanding shares of Series B Participating Preferred 
Stock from the Quarterly Dividend Payment Date next preceding 
the date of issue of such shares of Series B Participating 
Preferred Stock unless the date of issue of such shares is 
prior to the record date for the first Quarterly Dividend 
Payment Date, in which case dividends on such shares shall 
begin to accrue from the date of issue of such shares, or 
unless the date of issue is a Quarterly Dividend Payment Date 
or is a date after the record date for the determination of 
holders of shares of Series B Participating Preferred Stock 
entitled to receive a quarterly dividend and before such 
Quarterly Dividend Payment Date in either of which events 
such dividends shall begin to accrue and be cumulative from 
such Quarterly Dividend Payment Date.  Accrued but unpaid 
dividends shall not bear interest.  Dividends paid on the 
shares of Series B Participating Preferred Stock in an amount 
less than the total amount of such dividends at the time 
accrued and payable on such shares shall be allocated pro 
rata on a share-by-share basis among all such shares at the 
time outstanding.  The Board of Directors may fix a record 
date for the determination of holders of shares of Series B 
Participating Preferred Stock entitled to receive payment of 
a dividend or distribution declared thereon, which record 
date shall be no more than thirty (30) days prior to the date 
fixed for the payment thereof.

     Section 3.  Voting Rights.  The holders of shares of 
Series B Participating Preferred Stock shall have the 
following voting rights:

     (a)  Subject to the provision for adjustment hereinafter 
set forth, each share of Series B Participating Preferred 
Stock shall entitle the holder thereof to 10,000 votes on all 
matters submitted to a vote of the shareholders of the 
Corporation.  In the event the Corporation shall at any time 
after the Rights Declaration Date (i) declare any dividend on 
Common Stock payable in shares of Common Stock, 
(ii) subdivide the outstanding Common Stock into a greater 
number of shares, or (iii) combine the outstanding Common 
Stock into a smaller number of shares, by reclassification or 
otherwise, then in each such case the number of votes per 
share to which holders of shares of Series B Participating 
Preferred Stock were entitled immediately prior to such event 
shall be adjusted by multiplying such number by a fraction 
the numerator of which is the number of shares of Common 
Stock outstanding immediately after such event and the 
denominator of which is the number of shares of Common Stock 
outstanding immediately prior to such event.

     (b)  Except as otherwise provided herein or by law, the 
holders of shares of Series B Participating Preferred Stock 
and the holders of shares of Common Stock shall vote together 

                             -A-3-
<PAGE>

as one class on all matters submitted to a vote of 
shareholders of the Corporation.

     (c)  Except as set forth herein, holders of Series B 
Participating Preferred Stock shall have no special voting 
rights and their consent shall not be required (except to the 
extent they are entitled to vote with holders of Common Stock 
as set forth herein) for taking any corporate action.

     Section 4.  Certain Restrictions.

     (a)  Whenever quarterly dividends or other dividends or 
distributions payable on the Series B Participating Preferred 
Stock as provided in Section 2 are in arrears, thereafter and 
until all accrued and unpaid dividends and distributions, 
whether or not declared, on shares of Series B Participating 
Preferred Stock outstanding shall have been paid in full, the 
Corporation shall not:

          (i)  declare or pay dividends on, make any 
other distributions on, or redeem or purchase or 
otherwise acquire for consideration any shares of 
stock ranking junior (either as to dividends or 
upon liquidation, dissolution or winding up) to the 
Series B Participating Preferred Stock;

          (ii)  declare or pay dividends on or make any 
other distributions on any shares of stock ranking 
on a parity (either as to dividends or upon 
liquidation, dissolution or winding up) with the 
Series B Participating Preferred Stock except 
dividends paid ratably on the Series B Participating 
Preferred Stock and all such parity stock on 
which dividends are payable or in arrears in proportion 
to the total amounts to which the holders 
of all such shares are then entitled;

          (iii)  redeem or purchase or otherwise acquire 
for consideration shares of any stock ranking on a 
parity (either as to dividends or upon liquidation, 
dissolution or winding up) with the Series B 
Participating Preferred Stock provided that the 
Corporation may at any time redeem, purchase or 
otherwise acquire shares of any such parity stock 
in exchange for shares of any stock of the Corporation
ranking junior (either as to dividends or 
upon dissolution, liquidation or winding up) to the 
Series B Participating Preferred Stock; or

          (iv)  purchase or otherwise acquire for 
consideration any shares of Series B Participating 
Preferred Stock or any shares of stock ranking on a 
parity with the Series B Participating Preferred 

                             -A-4-
<PAGE>

Stock except in accordance with a purchase offer 
made in writing or by publication (as determined by 
the Board of Directors) to all holders of such 
shares upon such terms as the Board of Directors, 
after consideration of the respective annual dividend 
rates and other relative rights and preferences of 
the respective series and classes, shall 
determine in good faith will result in fair and 
equitable treatment among the respective series or 
classes.

     (b)  The Corporation shall not permit any subsidiary of 
the Corporation to purchase or otherwise acquire for 
consideration any shares of stock of the Corporation unless 
the Corporation could, under paragraph (a) of this Section 4, 
purchase or otherwise acquire such shares at such time and in 
such manner.

     Section 5.  Reacquired Shares.  Any shares of Series B 
Participating Preferred Stock purchased or otherwise acquired 
by the Corporation in any manner whatsoever shall be retired 
and canceled promptly after the acquisition thereof.  All 
such shares shall upon their cancellation become authorized 
but unissued shares of Preferred Stock and may be reissued as 
part of a new series of Preferred Stock to be created by 
resolution or resolutions of the Board of Directors, subject 
to the conditions and restrictions on issuance set forth 
herein.

     Section 6.  Liquidation, Dissolution or Winding Up.

     (a)  Upon any liquidation (voluntary or otherwise), 
dissolution or winding up of the Corporation, no distribution 
shall be made to the holders of shares of stock ranking 
junior (either as to dividends or upon liquidation, 
dissolution or winding up) to the Series B Participating 
Preferred Stock unless, prior thereto, the holders of shares 
of Series B Participating Preferred Stock shall have received 
per share, the greater of 10,000 times $1.00 or 10,000 times 
the payment proposed to be made per share of Common Stock 
pursuant to the second sentence of this Section 6(a), plus an 
amount equal to accrued and unpaid dividends and distributions 
thereon, whether or not declared, to the date of such 
payment (the "Series B Liquidation Preference").  Following 
the payment of the full amount of the Series B Liquidation 
Preference, no additional distributions shall be made to the 
holders of shares of Series B Participating Preferred Stock 
unless, prior thereto, the holders of shares of Common Stock 
shall have received an amount per share (the "Common 
Adjustment") equal to the quotient obtained by dividing (i) the 
Series B Liquidation Preference by (ii) 10,000 (as 
appropriately adjusted as set forth in subparagraph (c) below to 
reflect such events as stock 

                             -A-5-
<PAGE>

splits, stock dividends and recapitalization with respect to 
the Common Stock) (such number in clause (ii), the "Adjustment 
Number").  Following the payment of the full amount of the Series 
B Liquidation Preference and the Common Adjustment in respect 
of all outstanding shares of Series B Participating Preferred 
Stock and Common Stock, respectively, holders of Series B 
Participating Preferred Stock and holders of shares of Common 
Stock shall receive their ratable and proportionate share of the 
remaining assets to be distributed in the ratio of the Adjustment 
Number to 1 with respect to such Preferred Stock and Common Stock, 
on a per share basis, respectively.

     (b)  In the event there are not sufficient assets 
available to permit payment in full of the Series B Liquidation 
Preference and the liquidation preferences of all other 
series of Preferred Stock, if any, which rank on a parity 
with the Series B Participating Preferred Stock then such 
remaining assets shall be distributed ratably to the holders 
of such parity shares in proportion to their respective 
liquidation preferences.  In the event there are not sufficient 
assets available to permit payment in full of the 
Common Adjustment, then such remaining assets shall be 
distributed ratably to the holders of Common Stock.

     (c)  In the event the Corporation shall at any time 
after the Rights Declaration Date (i) declare any dividend on 
Common Stock payable in shares of Common Stock, 
(ii) subdivide the outstanding Common Stock, or (iii) combine 
the outstanding Common Stock into a smaller number of shares, 
by reclassification or otherwise, then in each such case the 
Adjustment Number in effect immediately prior to such event 
shall be adjusted by multiplying such Adjustment Number by a 
fraction the numerator of which is the number of shares of 
Common Stock outstanding immediately after such event and the 
denominator of which is the number of shares of Common Stock 
that were outstanding immediately prior to such event.

     Section 7.  Consolidation, Merger, etc.  In case the 
Corporation shall enter into any consolidation, merger, 
combination or other transaction in which the shares of 
Common Stock are exchanged for or changed into other stock or 
securities, cash and/or any other property, then in any such 
case the shares of Series B Participating Preferred Stock 
shall at the same time be similarly exchanged or changed in 
an amount per share (subject to the provision for adjustment 
hereinafter set forth) equal to 10,000 times the aggregate 
amount of stock, securities, cash and/or any other property 
(payable in kind), as the case may be, into which or for 
which each share of Common Stock is changed or exchanged.  In 
the event the Corporation shall at any time after the Rights 
Declaration Date (a) declare any dividend on Common Stock 
payable in shares of Common Stock, (b) subdivide the 

                             -A-6-
<PAGE>

outstanding Common Stock, or (c) combine the outstanding 
Common Stock into a smaller number of shares, then in each 
such case the amount set forth in the preceding sentence with 
respect to the exchange or change of shares of Series B 
Participating Preferred Stock shall be adjusted by multiplying 
such amount by a fraction the numerator of which is the number of 
shares of Common Stock outstanding immediately after such event and 
the denominator of which is the number of shares of Common Stock 
that are outstanding immediately prior to such event.

     Section 8.  Redemption.  The shares of Series B 
Participating Preferred Stock shall not be redeemable.

     Section 9.  Ranking.  The Series B Participating 
Preferred Stock shall rank junior to all other series of the 
Corporation's Preferred Stock as to the payment of dividends 
and the distribution of assets, unless the terms of any such 
series shall provide otherwise.

     Section 10.  Amendment.  The Articles of Incorporation 
and the Bylaws of the Corporation shall not be further 
amended (including, without limitation, pursuant to a 
Certificate of Determination filed pursuant to the authority 
granted by the Articles of Incorporation of the Corporation) 
in any manner which would materially alter or change the 
powers, preferences or special rights of the Series B 
Participating Preferred Stock so as to affect them adversely 
without the affirmative vote of the holders of at least 
sixty-six and two-thirds percent (66-2/3%) of the outstanding 
shares of Series B Participating Preferred Stock voting 
separately as a class.

     Section 11.  Fractional Shares.  Series B Participating 
Preferred Stock may be issued in fractions of a share which 
shall entitle the holder, in proportion to such holder's 
fractional shares, to exercise voting rights, receive 
dividends, participate in distributions and to have the 
benefit of all other rights of holders of Series B 
Participating Preferred Stock."

     2.  That no shares of Series B Participating Preferred 
Stock have been issued.

                             -A-7-
<PAGE>

     We further declare under penalty of perjury that the 
matters set forth in the foregoing Certificate of 
Determination are true and correct of our own knowledge.

     Executed at La Jolla, California on November 19, 1996.


                                  /s/ Peter Johnson
                                 ---------------------------
                                 Peter Johnson, President


                                 /s/ Gary E. Friedman
                                 ---------------------------
                                 Gary E. Friedman, Secretary


                             -A-8-
<PAGE>







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