AGOURON PHARMACEUTICALS INC
S-3/A, 1997-07-25
PHARMACEUTICAL PREPARATIONS
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      As filed with the Securities and Exchange Commission on July 25, 1997
                                                      Registration No. 333-29863

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             -----------------------

                                  PRE-EFFECTIVE
                                 AMENDMENT NO. 1
                                       TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                          Agouron Pharmaceuticals, Inc.
             (Exact name of registrant as specified in its charter)

          California                                       33-0061928
  (State or other jurisdiction                           (I.R.S. Employer
of incorporation or organization)                       Identification No.)
                             -----------------------

            10350 North Torrey Pines Road, La Jolla, California 92037
                                 (619) 622-8000
   (Address, including zip code, and telephone number, including area code, of
                   registrant's principal executive offices)

                                  Peter Johnson
                      President and Chief Executive Officer
                          AGOURON PHARMACEUTICALS, INC.
            10350 North Torrey Pines Road, La Jolla, California 92037
                                 (619) 622-8000
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)

                             -----------------------

     Approximate date of commencement of proposed sale to the public:  From time
to time after the effective date of this Registration Statement as determined by
the Selling Stockholders.
     If the only  securities  being  registered  on this Form are being  offered
pursuant to dividend or interest  reinvestment plans, please check the following
box. / /
     If any of the securities being registered on this Form are to be offered on
a delayed or continuous  basis  pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. /X/
     If this Form is filed to  register  additional  securities  for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list  the  Securities  Act  registration  statement  number  of the  earlier
effective registration statement for the same offering. / /
     If this Form is a  post-effective  amendment  filed pursuant to Rule 462(c)
under the  Securities  Act,  check the following box and list the Securities Act
registration  statement number of the earlier effective  registration  statement
for the same offering. / /
     If delivery of the  Prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /
<TABLE>
<CAPTION>
                                                CALCULATION OF REGISTRATION FEE
- --------------------------------------------------------------------------------------------------------------------------------
                                                                Proposed maximum
                                                                 offering price
 Title of each class of securities to be       Amount to be       per share(1)        Proposed maximum          Amount of
               registered                       registered                           aggregate offering        registration
                                                                                          price(1)                fee(2)
- --------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------====================
<S>                                              <C>                 <C>                 <C>                    <C>      
Common Stock, no par value..........             197,056             $85.375             $16,823,656            $5,098.08
- ------------------------------------------------------------------------------------------------------------====================
<FN>
(1) Calculated in accordance with Rule 457(c) under the Securities Act of 1933.
(2) Registration fee has been previously paid.
</FN>
</TABLE>
                             -----------------------

     The Registrant  hereby amends this  Registration  Statement on such date or
dates as may be necessary to delay its effective date until the Registrant shall
file a further  amendment  which  specifically  states  that  this  Registration
Statement shall  thereafter  become effective in accordance with Section 8(a) of
the  Securities  Act of 1933 or until the  Registration  Statement  shall become
effective on such date as the  Commission  acting  pursuant to said Section 8(a)
may determine.

================================================================================


<PAGE>

                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.  Other Expenses of Issuance and Distribution

         The following  table sets forth the expenses,  other than  underwriting
discounts and commissions, payable by the Company in connection with the sale of
the Common Stock being registered.  All amounts shown are estimates,  except the
registration fee.

<TABLE>
<CAPTION>
<S>                                                                          <C>   

    Securities and Exchange Commission Registration Fee...................  $     5,098.08
    Accounting Fees and Expenses  ........................................        2,000.00
    Miscellaneous.........................................................        5,000.00
                                                                            --------------
                                                                            $    12,098.08
                                                                            ==============
</TABLE>

Item 15.  Indemnification of Directors and Officers

         Section  317  of  the  California  General  Corporation  Law  generally
provides  indemnification  to officers  and  directors  of the  Company  against
expenses,  judgments,  fines  and  amounts  paid  in  settlement  under  certain
conditions and subject to certain limitations.

         Article VII of the articles of  incorporation  of the Company  provides
that  liability of the  directors of the Company for monetary  damages  shall be
eliminated to the fullest extent  permissible  under  California  law.  Further,
Article VIII of the articles of incorporation  authorizes the Company to provide
indemnification  of agents (as defined in Section 317) for breach of duty to the
Company and its shareholders through bylaw provisions or through agreements with
such agents, or both, in excess of the  indemnification  otherwise  permitted by
Section 317, subject to the limits on such excess  indemnification  set forth in
Section 317.

         Section  3.15 of the bylaws of the  Company  authorizes  the Company to
indemnify any person who was or is a party, or is threatened to be made a party,
to any  proceeding  (other  than  actions  by or in the right of the  Company to
procure a judgment  in its  favor) by reason of the fact that such  person is or
was an agent of the Company, against expenses, judgments, fines, settlements and
other  amounts  actually  and  reasonably   incurred  in  connection  with  such
proceeding  if such  person  acted in good  faith  and in a manner  such  person
reasonably  believed to be in the best  interests of the  Company.  Section 3.15
also authorizes the Company to indemnify any person who was or is a party, or is
threatened to be made a party, to any threatened, pending or completed action by
or in the right of the  Company to procure a judgment  in its favor by reason of
the fact that such  person is or was an agent of the  Company  against  expenses
actually and reasonably  incurred by such person in connection  with the defense
or settlement of such action if such person acted in good faith.

         Any  indemnification  under  Section  3.15 is to be made by the Company
only if authorized in the specific case upon determination that  indemnification
of the  agent is  proper  in the  circumstances  because  the  agent has met the
applicable  standard of conduct  required by Paragraphs  3.15.2 or 3.15.3 of the
bylaws.

         Pursuant to authorization  provided under the articles of incorporation
and the bylaws,  the Company has entered into  indemnification  agreements  with
each of its  present  directors.  The  Company  has also  entered  into  similar
agreements  with  certain  of the  Company's  officers  who are  not  directors.
Generally,  the  indemnification  agreements  attempt  to  provide  the  maximum
protection  permitted by California  law as it may be amended from time to time.
Moreover,   the  indemnification   agreements  provide  for  certain  additional
indemnification.  Under such additional indemnification provisions,  however, an
individual  will not  receive  indemnification  for  judgments,  settlements  or
expenses if he or she is found  liable to the Company  (except to the extent the
court  determines he or she is fairly and  reasonably  entitled to indemnity for
expenses) for  settlements  not approved by the Company or for  settlements  and
expenses if the  settlement  is not approved by the court.  The  indemnification
agreements  provide  for the  Company to advance to the  individual  any and all
reasonable   expenses   (including   legal  fees  and   expenses)   incurred  in
investigating  or defending  any such action,  suit or  proceeding.  In order to
receive an advance of expenses, the individual must submit to the Company copies
of invoices presented to him or her for such expenses. Also, the individual must
repay  such  advances  upon a  final  judicial  decision  that  he or she is not
entitled to indemnification.

         Section  3.15 of the  bylaws  also  provides  that,  in the  event of a
determination by the Board of Directors of the Company to purchase insurance for
certain of its agents,  the Company  shall  purchase and  maintain  insurance on
behalf of any such agent against  liability  asserted against or incurred by the
agent in such capacity or arising out of the agent's status,  whether or not the
Company would have the power to indemnify the agent against such liability under
the provisions of Section 3.15.

         The Company has in effect  directors and officers  liability  insurance
policies which insure directors and officers of the Company. The policies expire
on October 13, 1997.  Although  the Company  intends to renew the policies on or
before their  expiration  date, there can be no assurance that the policies will
be renewed on terms acceptable to the Company. Under the policies, the directors
and  officers of the Company are insured  against  loss arising from claims made
against  them  due to  wrongful  acts  while acting  in  their  individual  and 
collective capacities as directors and officers,  subject to certain exclusions.
In  addition,  the  policies  

                                      II-1
<PAGE>
insure the  Company  against  losses for which its directors and officers are 
entitled to  indemnification,  subject to a retention of $250,000 payable by the
Company. The policies are "claims made" policies and provide  coverage  only for
losses arising out of claims first made against the Company and reported to the 
insurer during the policy period.

Item 16.  Exhibits

          EXHIBIT
          NUMBER

            5.1*       Opinion of Gary E. Friedman, Esq.

           23.1        Consent of Independent Accountants.

           23.2*       Consent of Gary E. Friedman, Esq. (contained in 
                       Exhibit 5.1).

           24.1*       Power of Attorney (contained on signature page of the 
                       Registration Statement).

- ----------------------------
*  Previously filed.

Item 17.  Undertakings

         Insofar as indemnification for liabilities arising under the Securities
Act  may  be  permitted  to  directors,  officers  or  persons  controlling  the
registrant,  pursuant  to the  foregoing  provisions,  the  registrant  has been
advised  that in the opinion of the  Securities  and  Exchange  Commission  such
indemnification  is against public policy as expressed in the Securities Act and
is,  therefore,  unenforceable.  In the event  that a claim for  indemnification
against such  liabilities  (other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of counsel the matter has
been  settled  by  controlling  precedent,  submit  to a  court  of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.

         The undersigned registrant hereby undertakes that:

         (1) For purposes of determining any liability under the Securities Act,
the  information  omitted  from  the  form of  prospectus  filed as part of this
registration  statement  in reliance  upon Rule 430A and  contained in a form of
prospectus  filed by the registrant  pursuant to Rule 424(b)(1) or (4) or 497(h)
under  the  Securities  Act  shall  be  deemed  to be part of this  registration
statement as of the time it was declared effective.

         (2) For the purpose of determining  any liability  under the Securities
Act, each  post-effective  amendment that contains a form of prospectus shall be
deemed to be a new  registration  statement  relating to the securities  offered
therein,  and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

         The  undersigned  registrant  hereby  undertakes  that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  Annual  Report  pursuant to Section  13(a) or Section 15(d) of the
Exchange Act (and, where  applicable,  each filing of an employee benefit plan's
Annual  Report   pursuant  to  Section  15(d)  of  the  Exchange  Act)  that  is
incorporated by reference in the registration  statement shall be deemed to be a
new registration  statement relating to the securities offered therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

                                   SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this amendment to
registration statement to be signed on its behalf by the undersigned,  thereunto
duly authorized,  in the City of San Diego, State of California, on the 25th day
of July, 1997.

                                      AGOURON PHARMACEUTICALS, INC.

                                      By: /s/ Steven S. Cowell
                                          Steven S. Cowell
                                          Corporate Vice President, Finance
                                          and Chief Financial Officer


                                      II-2
<PAGE>




     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has been signed below by the  following  persons in the
capacities and on the dates indicated.
<TABLE>
<CAPTION>

            Signature                                       Title                                  Date
<S>                                                  <C>                                       <C>

     * Peter Johnson                                 President, Chief Executive                July 25, 1997
- ------------------------------------------
Peter Johnson                                        Officer and Director

     /s/ Steven S. Cowell                            Corporate Vice President, Finance         July 25, 1997
- ------------------------------------------
Steven S. Cowell                                     and Chief Financial Officer

     * Gary  E. Friedman                             Corporate Vice President, General         July 25, 1997
- ------------------------------------------
Gary E. Friedman                                     Counsel, Secretary and Director

     * John N. Abelson                               Director                                  July 25, 1997
- ------------------------------------------
John N. Abelson

     * Patricia M. Cloherty                          Director                                  July 25, 1997
- ------------------------------------------
Patricia M. Cloherty

     * A.E. Cohen                                    Director                                  July 25, 1997
A.E. Cohen

     * Michael E. Herman                             Director                                  July 25, 1997
- ------------------------------------------
Michael E. Herman

     * Irving S. Johnson                             Director                                  July 25, 1997
- ------------------------------------------
Irving S. Johnson

     * Antonie T. Knoppers                           Director                                  July 25, 1997
- ------------------------------------------
Antonie T. Knoppers

     * Melvin I. Simon                               Director                                  July 25, 1997
- ------------------------------------------
Melvin I. Simon


*By:   /s/ Steven S. Cowell                                                                    July 25, 1997
       -----------------------------------
       Steven S. Cowell
</TABLE>

                                      II-3
<PAGE>


                                  EXHIBIT INDEX

                5.1*       Opinion of Gary E. Friedman, Esq.

                23.1       Consent of Independent Accountants.

                23.2*      Consent of Gary E. Friedman, Esq. (contained in 
                           Exhibit 5.1).

                24.1*      Power of Attorney (contained on signature page of the
                           Registration Statement).


- ----------------------------
*  Previously filed.



                                      II-4


                                                                    EXHIBIT 23.1




CONSENT OF INDEPENDENT ACCOUNTANTS



We  hereby  consent  to  the   incorporation  by  reference  in  the  Prospectus
constituting part of this Registration Statement on Form S-3 of our report dated
August 7, 1996 appearing on page F-1 of Agouron  Pharmaceuticals,  Inc.'s Annual
Report on Form 10-K for the year ended  June 30,  1996.  We also  consent to the
reference to us under the heading "Experts" in such Prospectus.




PRICE WATERHOUSE LLP

San Diego, California
July 25, 1997




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