AGOURON PHARMACEUTICALS INC
10-Q, 1997-01-28
PHARMACEUTICAL PREPARATIONS
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                            UNITED STATES
                   SECURITIES AND EXCHANGE COMMISSION
                        Washington, D.C. 20549

                              FORM 10-Q

       (X)    QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE 
                    SECURITIES EXCHANGE ACT OF 1934

           For the quarterly period ended December 31, 1996

                                 OR

      (  )   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)
                OF THE SECURITIES EXCHANGE ACT OF 1934

                    Commission File Number 0-15609

                     AGOURON PHARMACEUTICALS, INC.
         (Exact name of registrant as specified in its charter)

          CALIFORNIA                              33-0061928
  (State or other jurisdiction of       I.R.S. employer identification no.)
  incorporation or organization)

        10350 NORTH TORREY PINES ROAD, LA JOLLA, CALIFORNIA  92037-1020
             (Address and zip code of principal executive offices)

                             (619) 622-3000
            (Registrant's telephone number, including area code)

                                   NONE
            (Former name, former address and former fiscal year,
                      if changed since last report.)

Indicate by check mark whether the registrant (1) has filed all reports 
required to be filed by Section 13 or 15(d) of the Securities Exchange Act 
of 1934 during the preceding 12 months (or for such shorter period that 
the registrant was required to file such reports), and (2) has been 
subject to such filing requirements for the past 90 days:  

                              Yes  _X_  No ___


Indicate the number of shares outstanding of each of the issuer's classes 
of common stock, as of the latest practicable date:  Approximately 
13,563,000 shares of the Company's Common Stock, no par value, were 
outstanding as of January 8, 1997. 


<PAGE>
                        AGOURON PHARMACEUTICALS, INC.

                                    INDEX

                                                                   Page No.
                                                                   --------

Part I.     Financial Information

Item 1.          Financial Statements

                 Balance Sheet -                                      3
                      December 31, 1996 and June 30, 1996

                 Statement of Operations - Three and Six              4
                      Months Ended December 31, 1996 and 1995

                 Statement of Cash Flows-                             5
                      Six Months Ended December 31, 1996 and 1995

                 Notes to Financial Statements                        6

Item 2.     Management's Discussion and Analysis of Financial         8
                 Condition and Results of Operations


Part II.    Other Information

Item 1.     Legal Proceedings                                        10

Item 2.     Changes in Securities                                    10

Item 3.     Defaults Upon Senior Securities                          10

Item 4.     Submission of Matters to a Vote of Security Holders      11

Item 5.     Other Information                                        11

Item 6.     Exhibits and Reports on Form 8-K                         11

            Signature                                                13

                                    2

<PAGE>
PART I.  FINANCIAL INFORMATION

Item 1.  Financial Statements

                        AGOURON PHARMACEUTICALS, INC.
                               BALANCE SHEET
                           (Dollars in thousands)

                                                 December 31,     June 30,
                                                         1996         1996
                                                 ------------  -----------
                                                   (unaudited)
ASSETS

Current assets:
    Cash and cash equivalents                   $    16,827    $    16,451
     Short-term investments                          92,071         74,424
     Accounts receivable                              6,151          2,966
     Inventory                                       21,400              0
     Other current assets                             1,370          1,800
                                               ------------    -----------

     Total current assets                           137,819         95,641

Property and equipment, net of
     accumulated depreciation and
     amortization of $15,241 and $13,710              9,405          6,936
                                                -----------     ----------

                                                $   147,224    $   102,577
                                                ===========    ===========

LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
     Accounts payable                           $     3,895   $      6,659
     Accrued liabilities                              4,951          4,327
     Deferred revenue                                 9,085         13,788
     Current portion of long-term debt                  348            486
                                                ------------   -----------

     Total current liabilities                       18,279         25,260
                                                ------------   -----------

Long-term liabilities:
     Long-term debt, less current portion               441            501
     Accrued rent                                     1,183          1,233
                                                -----------    -----------

     Total long-term liabilities                      1,624         1,734
                                                ------------   -----------

Stockholders' equity:
     Common stock, no par value, 75,000,000 shares
     authorized, 13,558,840 and 10,731,687 shares
     issued and outstanding                         237,369        158,628
     Accumulated deficit                           (110,048)       (83,045)
                                                -----------    -----------

     Total stockholders' equity                     127,321         75,583
                                                -----------    -----------

                                                 $   147,224   $   102,577
                                                 ===========   ===========


               See accompanying notes to financial statements.

                                    3

<PAGE>
                         AGOURON PHARMACEUTICALS, INC.
                           STATEMENT OF OPERATIONS
                                 (Unaudited)
               (Dollars in thousands, except per share amounts)



                                    Three Months Ended    Six Months Ended
                                    ------------------    ----------------
                                          December 31,        December 31,
                                    ------------------    ----------------

                                      1996     1995        1996      1995  
                                    --------  -------   --------  --------

Revenues:
     Contracts and licenses         $ 15,109  $ 9,592   $ 32,623  $ 20,555
                                    --------  -------   --------  --------
Operating expenses:
     Research and development         23,302   14,188     52,936    26,716
     Selling, general and
       administrative                  5,786      977      9,522     2,083
                                    --------  -------   --------  --------


                                      29,088   15,165     62,458    28,799
                                    --------  -------   --------  --------


Operating loss                       (13,979)  (5,573)   (29,835)   (8,244)
                                    --------  -------   --------  --------


Other income and expenses:
     Interest, net                     1,729    1,556      3,444     1,847
     Taxes                              (306)    (115)      (612)     (258)
                                    --------  -------   --------  --------


                                       1,423    1,441      2,832     1,589
                                    --------  -------   --------  --------


Net loss                            $(12,556) $(4,132)  $(27,003)  $(6,655)
                                    ========  =======   ========  ========


Net loss per common share           $  (0.93) $ (0.40)  $  (2.07)  $ (0.73)
                                    ========  =======   ========  ========


Shares used in computing net 
    loss per common share             13,524   10,432     13,050     9,076
                                    ========  =======   ========  ========










                See accompanying notes to financial statements.

                                    4

<PAGE>
                       AGOURON PHARMACEUTICALS, INC.
                           STATEMENT OF CASH FLOWS
                                 (Unaudited)
                            (Dollars in thousands)


                                                      Six Months Ended     
                                             ------------------------------
                                                          December 31,     
                                             ------------------------------
                                                   1996              1995  
                                             ------------     -------------

Cash flows from operating activities:
     Cash received from contracts
        and licenses                         $     24,735     $     31,990
     Cash paid to suppliers, employees
        and service providers                     (84,701)         (24,039)
     Interest received                              3,524            1,994
     Interest paid                                    (80)            (147)
                                             ------------     ------------

     Net cash provided (used) by 
       operating activities                       (56,522)           9,798
                                             ------------     ------------

Cash flows from investing activities:
     Net (increase) decrease 
       in short-term investments                  (17,647)         (82,248)
     Expenditures for property and equipment       (3,937)            (905)
                                             ------------     ------------

     Net cash provided (used) by 
       investing activities                       (21,584)         (83,153)
                                             ------------     ------------

Cash flows from financing activities:     
     Net proceeds from issuance of common stock    78,741           80,105
     Principal payments under equipment leases        (76)            (218)
     Increase (decrease) in long-term debt, net      (183)            (261)
                                             ------------     ------------

     Net cash provided (used) by 
       financing activities                        78,482           79,626
                                             ------------     ------------


Net increase (decrease) in cash and
  cash equivalents                                    376            6,271

Cash and cash equivalents at
  beginning of period                              16,451            4,358
                                             ------------     ------------

Cash and cash equivalents at end of period   $     16,827     $     10,629
                                             ============     ============

Reconciliation of net loss to net cash 
  provided (used) by operating activities:
     Net loss                               $     (27,003)    $     (6,655)
     Depreciation and amortization                  1,529            1,102
     Net (increase) decrease in
       accounts receivable                         (3,185)             130
     Net (increase) decrease in inventory         (21,400)               0
     Net (increase) decrease in other 
       current assets                                 430              (48)
     Net increase (decrease) in accounts
       payable, accrued liabilities, 
       and accrued rent                            (2,190)           3,964
     Net increase (decrease) in
     deferred revenue                              (4,703)          11,305
                                             ------------     ------------

     Net cash provided (used) 
       by operating activities              $     (56,522)     $     9,798
                                             ============     ============

                  See accompanying notes to financial statements.



                                    5


<PAGE>
                        AGOURON PHARMACEUTICALS, INC.
                        NOTES TO FINANCIAL STATEMENTS
                                 (Unaudited)

1.     Nature of operations

Agouron Pharmaceuticals, Inc. is involved in the research and development 
of novel synthetic drugs for the treatment of cancer, AIDS and other 
serious diseases.  The Company intends to commercialize any successfully 
developed products through its own direct sales and marketing activities in 
certain markets or, when appropriate, through manufacturing and marketing 
relationships with other pharmaceutical companies.

2.     Financial statements and estimates

The balance sheet as of December 31, 1996 and the statements of operations 
and cash flows for the three-month and six-month periods ended December 31, 
1996 and 1995 have been prepared by the Company and have not been audited. 
Such financials, in the opinion of management, include all adjustments 
(consisting only of normal, recurring accruals) necessary to present fairly 
the financial position, results of operations and cash flows for all 
periods presented.  These financial statements should be read in 
conjunction with the financial statements and notes thereto included in the 
Company's June 30, 1996 Annual Report on Form 10-K.  Certain June 30, 1996 
and December 31, 1995 amounts have been reclassified to conform with the 
current year presentation.  Interim operating results are not necessarily 
indicative of operating results for the full year.

The preparation of financial statements in conformity with generally 
accepted accounting principles requires management to make estimates and 
assumptions that affect the reported amounts of assets, liabilities, 
revenues and expenses and related disclosures as of the date of the 
financial statements.  Actual results could differ from such estimates.

At December 31, 1996, it has been assumed that the existing collaborations 
with Japan Tobacco Inc. ("JT") and Hoffmann-La Roche Inc. and F. Hoffmann-
La Roche Ltd ("Roche") will continue in accordance with their agreement 
terms.  As such, approximately $9,034,000 of cash received from JT and 
Roche has been classified as deferred contract revenue, is non-refundable 
and is being recognized as revenue on a prospective basis as collaborative 
program expenses are incurred.  Should any of the underlying collaborations 
be terminated in advance of their contract terms, any deferred contract 
revenues related to such collaborations would immediately be recognized as 
revenue by the Company.

In December 1996, the Company filed a New Drug Application ("NDA") with the 
United States Food and Drug Administration ("FDA") for its anti-HIV drug, 
VIRACEPT(R) (nelfinavir mesylate).  In anticipation of the approval of such 
NDA by the FDA, the Company is manufacturing commercial quantities of 
VIRACEPT and has capitalized approximately $21,400,000 of work-in-process 
inventory at December 31, 1996.  If the FDA does not approve the NDA or it 
becomes likely that the FDA will not approve the NDA, any capitalized 
VIRACEPT inventory will be expensed.

                                    6


<PAGE>
3.     Short-term investments

Included in short-term investments at December 31, 1996 and June 30, 1996 
is $1,360,000 and $1,156,000 of accrued interest receivable.  Included in 
short-term investments at December 31, 1996 is $3,400,000 which has been 
pledged as collateral for certain commercial letters of credit or long-term 
debt obligations.  At December 31, 1996, the Company's short-term 
investments are generally available for sale, are carried at amortized cost 
which approximates market, consist principally of United States government 
securities (64%) and corporate obligations (29%), and have average 
maturities of less than one year.

Inventory

Inventory is stated at the lower of cost or market and, at December 31, 
1996, consists of work-in-process at contract manufacturers.

5.     Statement of cash flows

Non-cash financing activities were comprised of capital lease obligations 
of $61,000 and $457,000 in the six-month periods ended December 31, 1996 
and 1995.

Certain concentrations

A significant portion of the Company's research and development 
expenditures are related to programs funded in whole or in part by JT and 
Roche.  The termination of such collaborative research and development 
programs could result in the absence of any prospective funding for such 
programs and the need to evaluate the level of future program spending, if 
any.

7.     Subsequent event

On January 17, 1997, pursuant to a binding letter of intent, the Company 
and JT granted F. Hoffmann-La Roche Ltd ("Roche") exclusive marketing 
rights for VIRACEPT in Europe and other countries outside North America, 
Japan and Asia.  For the marketing rights, Roche has paid to Agouron and JT 
an initial license fee of $18,000,000 and will pay an additional 
$22,000,000 when VIRACEPT is first approved in Europe.  Roche will also pay 
royalties based on Roche's sales of VIRACEPT or, under certain conditions, 
on combined sales of VIRACEPT and INVIRASE, Roche's HIV protease inhibitor. 
On January 24, 1997, the Company received its share of the initial license 
fee, $9,000,000.

                                    7

<PAGE>
Item 2.     Management's Discussion and Analysis of Financial Condition and 
Results of Operations

When used in this discussion, the words "believes", "anticipated" and 
similar expressions are intended to identify forward-looking statements. 
Such statements are subject to certain risks and uncertainties which could 
cause actual results to differ materially from those projected.  See 
"Important Factors Regarding Forward-Looking Statements" attached as 
Exhibit 99 to the Company's Annual Report on Form 10-K for the year ended 
June 30, 1996 and incorporated herein by reference.  Readers are cautioned 
not to place undue reliance on these forward-looking statements which speak 
only as of the date hereof.  The Company undertakes no obligation to 
publicly release the result of any revisions to these forward-looking 
statements which may be made to reflect events or circumstances after the 
date hereof or to reflect the occurrence of unanticipated events.

Financial Condition

The Company relies principally on equity financings and corporate 
collaborations to fund its operations and capital expenditures.  At 
December 31, 1996, the Company had increased its net working capital 
position by $49,159,000 over June 30, 1996 levels to $119,540,000.  The 
increase is due principally to the net proceeds of approximately 
$77,347,000 from a public offering of common stock in July 1996, which 
contributed, in part, to an $18,023,000 increase in cash, cash equivalents 
and marketable securities, the purchase of $21,400,000 of inventory and 
satisfying the cash requirements associated with the Company's year-to-date 
net loss of $27,003,000.  At December 31, 1996, the Company had cash, cash 
equivalents and short-term investments of approximately $108,898,000.  The 
Company believes that its current capital resources and existing 
contractual commitments are sufficient to maintain its current and planned 
operations through fiscal 1998.  This belief is based on current research 
and clinical development plans, anticipated working capital requirements 
associated with the planned commercial launch of VIRACEPT during fiscal 
1997, anticipated VIRACEPT product contribution subsequent to its 
commercial launch, the current regulatory environment, historical industry 
experience in the development of therapeutic drugs and general economic 
conditions.  The Company believes that additional financing may be required 
to meet the planned operating needs of fiscal 1999 if significant positive 
cash flows are not generated from commercial activities.  Such needs would 
include the expenditure of substantial funds to continue research and 
development activities, conduct existing and planned preclinical studies 
and tests, conduct human clinical trials and to support a growing 
commercial infrastructure including certain manufacturing, sales and 
marketing capabilities.  As a result, the Company anticipates pursuing 
various financing alternatives such as collaborative arrangements and 
additional public offerings or private placements of Company securities. 
If such alternatives are not available, the Company may be required to 
delay or eliminate expenditures for certain of its potential products under 
development or to license third parties to commercialize products or 
technologies that the Company would otherwise seek to develop or 
commercialize itself. 



                                    8


<PAGE>
Results of Operations

The Company is engaged in the research and development of human 
pharmaceuticals utilizing protein structure-based drug design.  Such 
research and development has been funded from the Company's equity-derived 
working capital and through various collaborative arrangements.  The 
Company's net operating losses reflect primarily the result of its 
independent research and continued increasing investment in clinical and 
commercial development activities concentrated on the Company's lead 
compounds in cancer and AIDS.  As product sales may not begin prior to 
fiscal 1998 and certain programs are expanding their preclinical, clinical, 
and commercial development activities, it is anticipated that quarterly net 
losses will continue into fiscal 1998.

The increases in the net losses for the three and six months ended December 
31, 1996 compared to the year-earlier periods are due principally to the 
Company's ongoing commitment to support significant clinical testing and 
development activities to facilitate an approvable VIRACEPT NDA during 
fiscal 1997, and to establish a commercial infrastructure to achieve a 
timely commercial launch of VIRACEPT subsequent to the anticipated approval 
of the NDA.  These spending increases were only partially offset by 
increased revenues from the JT collaboration and new revenues from the 
Roche collaboration.

Contract revenues in the current three and six-month periods have increased 
compared to the year-earlier periods due mainly to expanding clinical trial 
activities on the anti-HIV collaboration with JT and the new (June 1996) 
development collaboration with Roche. 

Research and development expenses increased from the prior-year periods due 
generally to increasing average research and development staff levels 
(approximately 42% in the three and six month periods) and staff-related 
expenditures, including occupancy, and significantly increased expenditures 
for human clinical trial activities associated with the Company's leading 
product development program, VIRACEPT.

The increase in selling, general and administrative expenses in the current 
three and six-month periods is due chiefly to increasing average staff 
levels (approximately 207% in the three month period and 171% in the six 
month period) and staff related expenditures, certain premarketing costs 
associated with the anticipated launch of VIRACEPT during fiscal 1997 and 
other costs associated with a growing sales and marketing infrastructure.

Interest (net) has increased in the current-year periods due principally to 
a higher average investment portfolio balance resulting from the previously 
described public offering.  Taxes have increased due to certain foreign 
taxes paid in conjunction with the JT collaboration. 


                                    9


<PAGE>
PART II.     OTHER INFORMATION

Item 1.     Legal Proceedings:

The Company is involved in certain legal or administrative proceedings 
generally incidental to its normal business activities.  While the outcome 
of any such proceedings cannot be accurately predicted, the Company does 
not believe the ultimate resolution of any such existing matters should 
have a material adverse effect on its financial position or results of 
operations.

Item 2.     Changes in Securities:

On November 7, 1996, the Board of Directors of the Company adopted a 
Stockholder Rights Plan.  Under the terms of the Rights Plan, stockholders 
of record as of November 21, 1996, received a dividend of one Preferred 
Stock Purchase Right for each share of Common Stock held on that date.  The 
Rights will expire 10 years after issuance, and will be exercisable only if 
a person or group becomes the beneficial owner of 15% or more of the Common 
Stock (such person or group, a "15% holder") or commences a tender or 
exchange offer which would result in the offeror beneficially owning 15% or 
more of the Common Stock.  Each Right will entitle stockholders to buy one 
one-ten thousandth of a share of Series B Participating Preferred Stock of 
the Company at an exercise price of $500.00 per share subject to certain 
antidilution adjustments.

If a person or group accumulates 15% or more of the Common Stock, each 
Right (other than Rights held by a 15% holder and certain related parties, 
which will be voided) will be adjusted so that upon exercise the holder 
will have the right to receive that number of shares of Common Stock (or in 
certain circumstances, a combination of securities and/or assets) having a 
value of twice the exercise price of the Right.  In addition, if following 
the public announcement of the existence of a 15% holder the Company is 
involved in a merger or business combination or a sale of 50% or more of 
the Company's assets or earning power, each Right (other than Rights held 
by a 15% holder and certain related parties, which will be voided) will 
represent the right to purchase, at the exercise price, common stock of the 
acquiring entity having a value of twice the exercise price at the time. 
The Board of Directors will also have the right, following the public 
announcement of the existence of a 15% holder, to cause each Right (other 
than rights held by the 15% holder) to be exchanged for one share of Common 
Stock.

The Board of Directors is entitled to redeem the Rights at $0.001 per Right 
at any time prior to the public announcement of the existence of a 15% 
holder.

Item 3.     Defaults Upon Senior Securities:  None.
<PAGE>
Item 4.     Submission of Matters to a Vote of Security Holders:

The Company held its Annual Meeting of Shareholders on November 7, 
1996 and proxies for such meeting were solicited pursuant to Regulation 
14A.  There was no solicitation in opposition to management's nominees for 
directors as listed in the proxy statement and all such nominees were 
elected.  The names of directors elected at the meeting are:  John N. 
Abelson, Patricia M. Cloherty, A. E. Cohen, Gary E. Friedman, Michael E. 
Herman, Irving S. Johnson, Peter Johnson, Antonie T. Knoppers and Melvin I. 
Simon.  Each director received at least 12,132,574 votes in favor of their 
election.

     In addition, the shareholders voted on and approved two other 
proposals as listed in the proxy statement and summarized below.

1.     The shareholders approved the Company's 1996 Stock Option Plan.  The 
vote was 5,048,130 for, 2,780,424 against, 49,863 abstained and 4,352,669 
not voted.

2.     The shareholders ratified the selection of Price Waterhouse as 
certified public accountants.  The vote was 12,198,258 for, 14,305 against 
and 18,523 abstained.

Item 5.     Other Information:

On January 17, 1997, pursuant to a binding letter of intent, the Company 
and JT granted F. Hoffmann-La Roche Ltd ("Roche") exclusive marketing 
rights for VIRACEPT in Europe and other countries outside North America, 
Japan and Asia.  For the marketing rights, Roche has paid to Agouron and JT 
an initial license fee of $18,000,000 and will pay an additional 
$22,000,000 when VIRACEPT is first approved in Europe.  Roche will also pay 
royalties based on Roche's sales of VIRACEPT or, under certain conditions, 
on combined sales of VIRACEPT and INVIRASE, Roche's HIV protease inhibitor.  
On January 24, 1997, the Company received its share of the initial license 
fee, $9,000,000.

                                    10

<PAGE>
Item 6.     Exhibits and Reports on Form 8-K:

Exhibits:

4.4**     Rights Agreement dated November 7, 1996, as amended on November 
27, 1996, between the Company. and Chase Mellon Shareholder Services, 
L.L.C., which includes, as Exhibit A, the Certificate of Determination, 
Preferences and Rights of Series B Participating Preferred Stock as filed 
with the California Secretary of State on November 20, 1996. 
10.63     Lease Amendment No. 3 dated October 16, 1996 between John Hancock 
Life Insurance Company and the Company
10.64     Sublease between The Scripps Research Institute and the Company dated 
November 4, 1996.
10.65     Premises Modification Agreement dated November 4, 1996 between 
The Scripps Research Institute and the Company
10.66     Lease dated October 25, 1996 between Scripps Jack, Ltd. and the 
Company
10.67     Form of 1990 Incentive Stock Option Agreement
10.68     Form of 1990 Non-Statutory Stock Option Agreement for 
Employees/Officers/Directors
10.69     Form of 1990 Non-Statutory Stock Option Agreement for Consultants
10.70*     1996 Stock Option Plan
10.71(     Form of 1996 Incentive Stock Option Agreement.
10.72(     Form of 1996 Non-Statutory Stock Option Agreement for 
Employees/Officers/Directors
10.73(     Form of 1996 Stock Option Agreement for Consultants
10.74     Letter of Intent between F. Hoffmann-La Roche Ltd of Basel, 
Switzerland, Japan Tobacco Inc., and the Company dated January 17, 1997. 
(Confidential treatment has been requested for portions of this agreement 
pursuant to an application dated January 27, 1997, as separately filed with 
the Securities and Exchange Commission)

27     Financial Data Schedule.  (Exhibit 27 is submitted as an exhibit 
only in the electronic format of this Quarterly Report on Form 10-Q 
submitted to the Securities and Exchange Commission)

27A     Financial Data Schedule (amended) for fiscal year ended June 30, 
1996
27B     Financial Data Schedule (amended) for the quarter ended September 
30,1996

b.     Reports on Form 8-K:  

     A report on Form 8-K dated November 7, 1996 was filed on November 8, 
1996.  Such report related to the adoption by the Board of Directors of the 
Company of a stockholder rights plan contemplating the issuance of rights 
to purchase Series B Participating Preferred Stock to the Company's common 
shareholders of record as of November 21, 1996.


*     Incorporated by reference to Form S-8 dated November 26, 1996.
**    Incorporated by reference to Form 8-A/A filed December 20, 1996, 
File No. 001-12445.


                                    11


<PAGE>
                                SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the 
registrant has duly caused this report to be signed on its behalf by the 
undersigned thereunto duly authorized.


                                AGOURON PHARMACEUTICALS, INC.




Date:  January 28, 1997         /s/ Steven S. Cowell     
                                -------------------------------------------
                                Steven S. Cowell
                                Vice President, Finance and Chief Financial
                                Officer and Chief Accounting Officer


                                    12

<PAGE>Normal4/5/96




                                                              EXHIBIT 10.63

                           LEASE AMENDMENT NO. 3

     THIS LEASE AMENDMENT NO. 3, is made this 16th day of October, 1996, by 
and between JOHN HANCOCK LIFE INSURANCE COMPANY, a Massachusetts Corporation 
("Landlord"), successor in interest to KOLL HANCOCK TORREY PINES, a 
California General Partnership, and AGOURON PHARMACEUTICALS, INC., a 
California Corporation ("Tenant").

     WHEREAS, by written lease dated December 8, 1992 Landlord leased to 
Tenant 10,255 rentable square feet of office space ("Original Space") 
located in Suite 100 of the office building known as TORREY PINES BUSINESS 
AND RESEARCH PARK ("Building"), located at 10350 North Torrey Pines Road, La 
Jolla, California, for a term of four (4) years, beginning on February 1, 
1993, and ending on April 30, 1997;

     WHEREAS, by written Lease Amendment No. 1, dated February 26, 1993, 
Landlord leased an additional 3,774 rentable square feet on the plaza level 
of the building to Tenant for a term commencing May 1, 1993 and terminating 
April 30, 1997;

     WHEREAS, by written Lease Amendment No. 2, dated February 17, 1994, 
Landlord leased an additional 4,909 rentable square feet on the second floor 
of the Building to Tenant for a term commencing May 1, 1994 and terminating 
April 30, 1997.  (The Lease, Lease Amendment No. 1, Lease Amendment No. 2 
and Lease Amendment No. 3 are hereinafter referred to as "the Lease");

     WHEREAS, Landlord and Tenant desire to extend the initial term of the 
Lease and make certain other modifications to the Lease;

     NOW, THEREFORE, in consideration of the above stated premises and of 
the mutual promises and of the mutual promises and undertakings contained 
herein, the parties hereto agree as follows:

     1.     The initial term of the Lease shall be extended two (2) years 
and four (4) months from May 1, 1997 with a new lease termination date of 
August 31, 1999.

     2.     Base Rent Schedule shall be payable as follows:

          Period               Total Monthly Base Rent

          5/1/96 - 4/30-97          $32,055.78
          5/1/97 - 5/31/97          $0.00
          6/1/97 - 4/30/98          $32,972.00
          5/1/98 - 4/30/99          $34,290.88
          5/1/99 - 8/31/99          $35,662.51

     3.     Landlord will be responsible for calendar year 1997 ("Base 
Year") Operating Costs.  Tenant will be responsible for any increase in 
Operating Costs above the 1997 calendar year Base Year.  The Base Year shall 
be calculated based upon a 100% leased Project.

     4.     There will be no parking fees for the Authorized Number of 
Parking Spaces during the term of the Lease or any extension thereof.

     5.     Expansion - Tenant will have the First Right to Negotiate 
(behind existing third party expansion rights) on any space in excess of 
10,000 square feet that becomes available in the Project during Tenant's 
lease term.

<PAGE>

     6.     Except as modified by this Lease Amendment No. 3, all other 
terms, covenants and conditions contained in the Lease shall remain in full 
force and effect.  Initially capitalized terms not otherwise defined herein 
and amendments shall have the same meaning as contained in the Lease.

     IN WITNESS WHEREOF, the parties hereto have executed this LEASE 
AMENDMENT NO. 3 as of the date first above written, the execution and 
delivery thereof having been duly authorized.

          LANDLORD:

          JOHN HANCOCK LIFE INSURANCE COMPANY,
          a Massachusetts Corporation

          By:  /s/ John M. Nagle
              -----------------------------
                John M. Nagle
          Its:  Senior Investment Officer


          TENANT:

          AGOURON PHARMACEUTICALS, INC.
          A California Corporation

          By:  /s/ Glenn Zinser
              -----------------------------
               Glenn Zinser
         Its:  VP Operations

         Date: 10/15/96 
               ----------------------------

                                        2    
<PAGE>

                                                             EXHIBIT 10.64
                                    SUBLEASE



1.     PARTIES

      This Sublease is entered into by and between THE SCRIPPS RESEARCH 
      INSTITUTE (hereinafter, "Sublessor") and AGOURON PHARMACEUTICALS, INC. 
      (hereinafter, "Sublessee"), as a Sublease under the Master Lease dated 
      January 26, 1994 entered into by THE REGENTS OF THE UNIVERSITY OF 
      CALIFORNIA as Landlord, and Sublessor under this Sublease as Tenant.  
      A copy of the Master Lease is attached hereto as Exhibit A and is 
      incorporated by reference herein.  This Agreement shall be effective 
      ("Effective Date") as of the later of November 1, 1996 or the date on 
      which TSRI delivers possession of any part of the Premises (as defined 
      below) to Agouron.

2.     PROVISIONS CONSTITUTING SUBLEASE

       A.    Except as otherwise provided herein, this Sublease is subject to 
             all of the terms and conditions of the Master Lease set forth in 
             Exhibit A hereto, and Sublessee shall comply with the terms and 
             conditions in said Master Lease, to the extent said terms and 
             conditions are applicable to the Premises subleased pursuant to 
             this Sublease.  Sublessee shall not commit or permit to be 
             committed on the Premises any act or omission which shall 
             violate any term or condition of the Master Lease.

       B.    Provided Sublessee is not in default hereunder, Sublessor agrees 
             not to exercise its early termination option as set forth in 
             paragraph 50 of the Master Lease.

       C.    No provision shall be construed to create any joint venture, 
             partnership, employer/employee, or agency relationship between 
             the parties to this Sublease agreement.

       D.    Except as otherwise provided herein, all of the terms and 
             conditions contained in the Master Lease (Exhibit A hereto) are 
             incorporated by reference as though fully set forth herein as 
             terms and conditions of this Sublease (with each reference 
             therein to Landlord and Tenant to be deemed to refer to 
             Sublessor and Sublessee) and, along with all of the following 
             Sections set out in this Sublease, shall be the complete terms 
             and conditions of this Sublease.

3.     PREMISES

       Sublessor leases to Sublessee and Sublessee hires from Sublessor the 
       following described Premises together with all improvements therein, 
       situated in the City of San Diego, County of San Diego, State of 
       California,  located at 10280 North Torrey Pines Road, Suites 485A and 
       485B, and a storage room provided by the Landlord in the 

                                      -1-
<PAGE>

       garage area (hereinafter, "Suite 485C"), totaling approximately 4550 
       rentable square feet (rsf), as outlined in the floor plan attached 
       hereto as Exhibit B and incorporated by reference herein.

4.     TERM

       A.    The term of this Sublease shall be for a period of two (2) years 
             and five (5) months, commencing on November 1, 1996 and ending 
             at midnight on March 31, 1999, unless sooner terminated pursuant 
             to any provision hereof.

       B.    On the last day of the term hereof or on any sooner termination, 
             Sublessee shall surrender the Premises to Sublessor in the same 
             condition as when received, ordinary wear and tear excepted, 
             clean and free of debris and ready for immediate occupancy by a 
             new tenant.

       C.    In the event Sublessor is unable to deliver possession of the 
             Premises at the commencement of the term, Sublessor shall not be 
             liable for any damage caused thereby, nor shall this Sublease be 
             void or voidable.  Sublessee shall not be liable for rent until 
             such time as Sublessor offers to deliver possession of the 
             Premises to Sublessee, but the term hereof shall not be extended 
             by such delay.  Should Sublessor be unable to deliver possession 
             of any portion of the Premises by December 31, 1996, this 
             Sublease shall be voidable at the sole option of Sublessee.  If 
             Sublessee, with Sublessor's consent, takes possession prior to 
             the commencement of the term, Sublessee shall do so subject to 
             all of the covenants and conditions hereof and shall pay rent 
             for the period ending with the commencement of the term at the 
             same rental as that prescribed for the first month of the term, 
             prorated at the rate of 1/30th thereof per day.

5.     RENT AND OTHER CHARGES PAYABLE BY SUBLESSEE

       Sublessee shall pay to sublessor as base rent ("Base Rent") for the 
       Premises in advance on the first day of each calendar month during the 
       remaining portion of the first calendar year of the term of this 
       Sublease (i.e., from November 1, 1996 through December 31, 1996) 
       without deduction, offset, prior notice or demand, in lawful money of 
       the United States, the sum of fourteen thousand, five hundred sixty 
       dollars ($14,560.00).  The Base Rent shall be adjusted according to 
       the provisions, schedules and indices set forth in Paragraphs 4 and 7 
       of the Master Lease attached as Exhibit A hereto.  Such adjustments to 
       the Sublessee's Base Rent shall be in a percentage equivalent to the 
       adjustments made to Sublessor's Base Rent under the Master Lease and 
       shall occur on the same date(s) that adjustments are made pursuant to 
       the Master Lease.

       If the commencement date is not the first day of a calendar month, or 
       if the Sublease termination date is not the last day of a calendar 
       month, a prorated monthly installment shall be paid at the then 
       current rate for the fractional month during which the Sublease 

                                      -2-
<PAGE>

       commences and/or terminates.  Said Base Rent shall include operating 
       expenses, utilities, and janitorial service, except as otherwise 
       provided herein.

       Receipt of $14,560.00 is hereby acknowledged for rental for the first 
       month.  Receipt of an additional $14,560.00 as a non-interest-bearing 
       security deposit for performance under this Sublease is also 
       acknowledged.  In the event Sublessee has performed all of the terms 
       and conditions of this Sublease throughout the term and has paid all 
       sums owing to Sublessor, upon Sublessee vacating the Premises, the 
       security deposit shall be returned to Sublessee.

6.     USE

       The Premises shall be used and occupied only for general office use 
       and for laboratories for scientific research, or any other use which 
       is reasonably comparable and for no other purpose.  The Premises shall 
       not be used or occupied for any purpose inconsistent with San Diego 
       Municipal Code Section 101.0434, which applies to areas zoned for 
       scientific research.

       Sublessee's business shall be established and conducted throughout the 
       term hereof in a first class manner.  Sublessee shall not use the 
       Premises for, or carry on, or permit to be carried on, any offensive, 
       noisy or dangerous trade, business, manufacture, or occupation, nor 
       permit any auction sale to be held or conducted on or about the 
       Premises.  Sublessee shall not do or suffer anything to be done upon 
       the Premises which will cause structural injury to the Premises or the 
       building of which the Premises forms a part.  The Premises shall not 
       be overloaded and no machinery, apparatus or other appliance shall be 
       used or operated in or upon the Premises which will in any manner 
       injure, vibrate, or shake the Premises or the building of which it is 
       a part.  No use shall be made of the Premises which will in any way 
       impair the efficient operation of the sprinkler system (if any) within 
       the building containing the Premises.  Sublessee shall not leave the 
       Premises unoccupied or vacant during the term.  No musical instrument 
       of any sort, or any noise making device, will be operated in or 
       allowed upon the Premises for the purpose of attracting trade or 
       otherwise.  Sublessee shall not use or permit the use of the Premises 
       or any part thereof for any purpose which will increase the existing 
       rate of insurance upon the building in which the Premises are located, 
       or cause a cancellation or non-renewal of any policy covering the 
       building or any part thereof.  If any action on the part of Sublessee 
       or use of the Premises by Sublessee shall cause, directly of 
       indirectly, any increase of Sublessor's insurance expense, said 
       additional expense shall be paid by Sublessee to Sublessor upon 
       written demand.  No such payment by Sublessee shall limit Sublessor in 
       the exercise of any other rights or remedies, or constitute a waiver 
       of Sublessor's right to require Sublessee to discontinue such act or 
       use.

                                      -3-
<PAGE>

7.     HAZARDOUS MATERIALS

       In addition to the provisions set forth in Paragraph 47 of the Master 
       Lease, Sublessee further agrees to the following provisions.

       A.    Sublessee shall indemnify Sublessor and Sublessor's affiliated 
             corporations, including TSRI, Scripps Health, Scripps Foundation 
             for Medicine and Science, and Scripps Institution of Medicine 
             and Science, and their respective trustees, officers, partners, 
             directors, shareholders, employees, contractors, agents, 
             successors, and assigns (collectively, "Sublessor's Persons") 
             and shall defend (with counsel previously approved by Sublessor 
             in writing, which approval shall not unreasonably be withheld) 
             and hold harmless Sublessor and Sublessor's Persons from and 
             against any and all claims, suits, court or administrative 
             proceedings, losses, costs, damages, liabilities, deficiencies, 
             fines, penalties, forfeitures, punitive damages or expenses 
             (including, without limitation, attorneys' fees), death of or 
             injury (including, without limitation, sickness or disease to 
             any person or tangible damage to any real or personal property 
             whatsoever, incurred by, arising out of, based upon or resulting 
             from (i) Sublessee's failure to perform or observe any of its 
             obligations or agreements under Paragraph 47 of the Master 
             Lease; (ii) the release, threatened release, generation, 
             discharge, storage, disposal or transportation of any Toxic 
             Material under, in or about, to or from the Premises occurring 
             or resulting from acts or omissions of Sublessee or Sublessee's 
             employees, agents, or invitees taking place on or after 
             Sublessee takes possession of the Premises (and not resulting 
             from any negligent or willful misconduct of Sublessor); or (iii) 
             the failure of Sublessee or its employees, agents or invitees to 
             comply with any environmental or hazardous substance laws.  The 
             foregoing indemnification shall survive the expiration of the 
             Term or earlier termination of this Sublease.

       B.    As a material inducement to Sublessor to allow Sublessee to use 
             Toxic Materials in connection with its activities, Sublessee 
             agrees to deliver to Sublessor on November 1, 1996, November 1, 
             1997, November 1, 1998, and March 31, 1999 ("Disclosure Dates"), 
             a report disclosing to Sublessor the names and amounts of all 
             Toxic Materials which were stored, used, transported upon, or 
             disposed of on the Premises, or which Sublessee intends to 
             store, use or dispose of on the Premises, for the year prior to 
             and after each Disclosure Date.  The matter to be identified in 
             the disclosure (the "Toxic Materials Report") shall be all 
             matter reasonably considered to be hazardous, toxic, infectious, 
             or radioactive, including all matter identified as Toxic 
             Materials or Hazardous Substances according to the Hazardous 
             Substance Laws referred to hereinabove.  Said Toxic Materials 
             Report shall also list any and all governmental approvals or 
             permits required in connection with the presence of such Toxic 
             Materials on the Premises and a copy of the Hazardous Substances 
             business plan prepared pursuant to Health and Safety Code 
             Sections 25500, et seq.  Sublessee shall deliver to Sublessor 
             true and correct copies of the following documents

                                      -4-
<PAGE>

             (hereinafter referred to as the "Documents"), relating to the 
             handling, storage, disposal and emission of Toxic Materials upon 
             written request:  (i) permits; (ii) approvals; (iii) reports and 
             correspondence relating to the release of Toxic Materials; (iv) 
             storage and maintenance plans; (v) notice of violations of any 
             laws; (vi) plans relating to the installation of any storage 
             tanks to be installed in or under the Premises (provided, said 
             installation of tanks shall only be permitted after Sublessor 
             has given Sublessee its written consent to do so, which consent 
             may be withheld in Sublessor's sole discretion); and (vii) all 
             closure plans or any other documents required by any and all 
             federal, state and local governmental agencies and authorities 
             for any storage tanks installed in, on or under the Premises.  
             Sublessor acknowledges that it is not the intent of this Section 
             to prohibit Sublessee from carrying on its operations or to 
             unreasonably interfere with such operations.  Sublessee may 
             carry on its operations according to the custom of the industry 
             so long as the use, presence and disposal of Hazardous Substance 
             is strictly and properly monitored according to all applicable 
             governmental requirements.

             The aforementioned disclosures shall be hand-delivered, sent via 
             courier, or sent via overnight delivery and shall be addressed 
             to:  Director, Environmental Health and Safety, The Scripps 
             Research Institute, 10550 North Torrey Pines Road, Mail Drop 
             BCC-078, La Jolla, CA 92037, phone: (619) 784-8240.

      C.     Notwithstanding the provisions of this Section, Sublessor shall 
             have the right to terminate this Sublease in the event that (i) 
             Sublessee uses the Premises for the generation, storage, use, 
             treatment or disposal of Toxic Materials in a manner prohibited 
             by applicable law and such use has a material adverse effect on 
             Sublessor or the Premises; (ii) Sublessee has been required by 
             any governmental authority to take remedial action in connection 
             with Toxic Materials contaminating the Premises if the 
             contamination resulted from Sublessee's action or use of the 
             Premises and such remedial action has a material adverse effect 
             on Sublessor or the Premises; or (iii) Sublessee is subject to 
             an enforcement order issued by any governmental authority in 
             connection with the use, disposal or storage of Toxic Materials 
             on the Premises and such enforcement order has a material 
             adverse effect on Sublessor or the Premises.  Each of the 
             foregoing events shall be deemed to be a material default by 
             Sublessee under this Sublease.

      D.     Upon the expiration or upon any early termination of this 
             Sublease, Premises shall be returned by Sublessee to Sublessor 
             in good operating condition and free of Toxic Materials.  At 
             that time, presuming there has been no release, discharge or 
             emission of Toxic Materials on the Premises during Sublessee's 
             occupancy thereof, Sublessee shall furnish to Sublessor, at 
             Sublessee's sole cost, the results of appropriate environmental 
             tests and studies as may be customary, reasonable, and in 
             accordance with all applicable requirements of governmental 
             entities and applicable environmental laws, so as to obtain 

                                      -5-
<PAGE>

             assurance that the Premises are free from any Toxic Materials or 
             contamination in excess of legally permissible levels.  If, 
             however, a release, discharge or emission of Toxic Materials has 
             occurred on the Premises during Sublessee's occupancy thereof, 
             Sublessee shall furnish to Sublessor, at Sublessee's sole cost, 
             a then-customary environmental audit or similar remediation plan 
             for the Premises, plus such additional tests and studies as may 
             be customary, reasonable or recommended by said audit, so as to 
             obtain a then-customary and reasonable verification that the 
             Premises are free from any Toxic Materials or contamination in 
             excess of legally permissible levels.  If said tests or studies 
             indicate that there are any impermissible levels of Toxic 
             Materials on the Premises, then, to the extent such 
             impermissible levels of Toxic Materials were generated by 
             Sublessee, Sublessee shall pay for all costs necessary to clean 
             up and remedy said impermissible levels of Toxic Materials to 
             the extent such levels of Toxic Materials are not permitted by 
             applicable governmental laws or regulations.  Sublessor shall 
             cooperate in good faith with Sublessee to approve a remediation 
             plan which mitigates the overall damages and costs. but if such 
             remediation plan involves a delay in completing the remediation, 
             then Sublessee shall agree to toll the statute of limitations 
             for the duration of said delay applicable to any claim against 
             Sublessee related to Sublessee's obligation to clean up Toxic 
             Materials.  Provided, however, Sublessee shall have no duty with 
             respect to any such Toxic Materials which (i) were on the 
             Premises prior to the effective date, or (ii) were placed on the 
             Premises by means of spillage or seepage from a neighboring 
             property, or (iii) were generated by Sublessor.

      E.     Sublessee's obligations under this section and under Paragraph 
             47 of the Master Lease shall survive the termination of this 
             Sublease.  During any period of time employed by Sublessee after 
             the termination of this Sublease to complete the removal from 
             the Premises of any such Toxic Materials, Sublessee shall 
             continue to pay the full Rent in accordance with this Sublease.  
             (Provided, however, to the extent that some or all of the 
             Premises continue to be used while the remediation work is being 
             conducted, then said rental income or value of the portion of 
             the Premises which are used shall be credited against the Rent 
             otherwise payable by Sublessee for the same premises and time 
             period.)

8.     MISCELLANEOUS PROVISIONS

      A.     Parking:  Sublessor shall provide Sublessee approximately 
             eighteen (18) parking spaces in the parking garage in accordance 
             with Paragraph 40 of the Master Lease (Exhibit A hereto).

      B.     Utility Usage:  Sublessor and Sublessee intend to prorate the 
             cost of utility usage including air conditioning, heating and 
             electrical usage based on Sublessor being responsible for fifty-
             five and five-tenths percent (55.5%) of such charges and 
             Sublessee being responsible for forty-four and five-tenths 
             percent (44.5%) of such charges.  Should either party use 
             excessive utility 

                                      -6-
<PAGE>

             services, then such party will be responsible for the cost of 
             the excess utility usage.

      C.     Telecommunications Room:  Sublessor, upon reasonable notice to 
             Sublessee, will have access to the telecommunications room 
             located in the Premises leased to Sublessee as outlined on the 
             floor plan attached hereto as Exhibit B.

     D.     Warm Room:  The parties hereto understand and acknowledge that 
             access to an incubation area or "warm room" is important to the 
             scientific research conducted by both parties.  Since the 
             Premises contain a warm room to which both parties hereto desire 
             access, Sublessee agrees that, until a replacement solution (in 
             the form of additional warm room facilities) is identified, 
             Sublessor shall have unrestricted, exclusive access to the warm 
             room facilities contained within the leased Premises.  In 
             consideration for said access, Sublessor agrees to reduce the 
             rent due to Sublessor from Sublessee by fifty percent (50%) 
             during the time Sublessor has access to the warm room facilities 
             within the leased Premises, until such time that a replacement 
             solution is in operation.  Sublessor further agrees to use its 
             reasonable best efforts to make a replacement solution 
             available.

      E.     First Right to Negotiate:  Sublessor will provide Sublessee with 
             a first right to negotiate to lease the remaining space occupied 
             by Sublessor if Sublessor vacates said space any time during the 
             term of the Sublease.

      F.     Storage Room:  Sublessor and Sublessee agree to prorate the cost 
             of the storage room which provides deionized water and other 
             services, whereby  Sublessee shall pay Sublessor a monthly 
             charge of $175.00/month with annual CPI adjustments, pursuant to 
             paragraph 49 of the Master Lease.


9.     NOTICES

       All notices or demands of any kind required or desired to be given by 
       Sublessor or Sublessee hereunder shall be in writing and shall be 
       deemed delivered forty-eight (48) hours after depositing the notice or 
       demand in the United States mail, certified or registered, postage 
       prepaid, addressed to the Sublessor or Sublessee, respectively, at the 
       addresses set forth after their signatures hereinbelow.  All rent and 
       other payments due pursuant to this Sublease or the Master Lease shall 
       be made by Sublessee to Sublessor at the same address.

///

///

                                      -7-
<PAGE>

          IN WITNESS WHEREOF, the parties have executed this 
Sublease by their duly authorized representatives as of the date set 
forth above.


SUBLESSOR:                              SUBLESSEE:

THE SCRIPPS RESEARCH INSTITUTE          AGOURON PHARMACEUTICALS, INC.


By:  /S/ DONNA J. WESTON                 By:  /S/ GLENN ZINSER
     ---------------------------              --------------------------- 
     Donna J. Weston

Title:  Vice President and               Title:  VP, Operations
        Chief Financial Officer

  10550 N. Torrey Pines Road             10350 N. Torrey Pines Road
  La Jolla, CA 92037                     La Jolla, CA 92037

Dated:  11/4/96                          Dated: 11/4/96          

                                      -8-
<PAGE>




                                                          EXHIBIT 10.65
               
                                    AGREEMENT

     This Premises Modification Agreement ("Agreement") is entered into by 
and between THE SCRIPPS RESEARCH INSTITUTE, a California nonprofit public 
benefit corporation located at 10550 North Torrey Pines Road, La Jolla, 
California 92037 ("TSRI"), and AGOURON PHARMACEUTICALS, INC., a California 
corporation located at 10350 N. Torrey Pines Road, La Jolla, California 
92037 ("Agouron"), with respect to the facts set forth below.  This 
Agreement shall be effective ("Effective Date") as of the later of November 
1, 1996 or the date on which TSRI delivers possession of any part of the 
Premises (as defined below) to Agouron pursuant to that certain Sublease 
Agreement (defined below).


                                    RECITALS

        1.     TSRI is a party to that certain Lease dated January 26, 1994 
               pertaining to certain rentable space located at 10280 North 
               Torrey Pines Road (the "Premises"); one party to said Lease, 
               the Regents of the University of California, is identified 
               therein as Landlord, while TSRI is identified therein as 
               Tenant.

        2.     Pursuant to a Sublease Agreement dated November 4, 1996 
               between TSRI and Agouron, a copy of which is attached hereto 
               as Exhibit A and the terms of which are incorporated by 
               reference herein, TSRI has agreed to sublease a portion of the 
               Premises leased to TSRI, to Agouron.

        3.     Both TSRI and Agouron require access to temperature-controlled 
               facilities in order to carry out their scientific research and 
               thus wish to expand the available temperature-controlled 
               facilities on the Premises for such use.  At present, one 
               temperature-controlled room is in use; a second temperature-
               controlled room requires repair.


                                    AGREEMENT

     NOW, THEREFORE, in consideration of the mutual covenants and 
conditions set forth herein, TSRI and Agouron hereby agree as follows:

        1.     A second pre-existing temperature-controlled room shall be 
               repaired so that it functions as a warm-room; all costs 
               incurred in the repair of said second temperature-controlled 
               room shall be shared equally by the parties hereto.  The 
               parties have agreed that TSRI shall pay the invoiced costs of 
               the repair of said second temperature-controlled room and 
               shall invoice Agouron for half of said 

                                    -1-
<PAGE>

               costs.  Agouron agrees to reimburse TSRI for said costs within 
               thirty (30) days of receiving an invoice for same.  Agouron 
               further agrees that early termination of the Sublease 
               Agreement (Exhibit A hereto) shall not relieve Agouron of its 
               obligation to reimburse TSRI for Agouron's half of the 
               aforementioned costs.  The parties hereto acknowledge that no 
               repair work shall commence until the consent of The Regents of 
               the University of California is received.

        2.     Once repair of the second temperature-controlled room is 
               completed and said room is ready for use, the parties hereto 
               agree that the second temperature-controlled room will be 
               available for exclusive use by TSRI, while the first 
               temperature-controlled room will be available for exclusive 
               use by Agouron, during the term of the Sublease Agreement 
               (Exhibit A hereto).

        3.     In addition to the repair of the second temperature-controlled 
               room, four (4) modular controlled environment chamber units 
               from Percival Scientific, Inc., the specifications of which 
               are set forth on Exhibit B hereto (hereinafter, "Percival 
               Units"), shall be purchased and installed on the Premises 
               within Sublessor's space.  The parties hereto acknowledge that 
               no installation work shall commence until the consent of The 
               Regents of the University of California is received.

        4.     All costs relating to acquisition and installation of the 
               Percival Units, including, without limitation, payment for any 
               build-out costs relating to installation of the Units, shall 
               be shared equally by TSRI and Agouron.  The parties have 
               agreed that TSRI shall pay the invoiced costs of acquisition, 
               installation, and build-out and shall invoice Agouron for half 
               of said costs.  Agouron agrees to reimburse TSRI for said 
               costs within thirty (30) days of receiving an invoice for 
               same.  Agouron further agrees that early termination of the 
               Sublease Agreement (Exhibit A hereto) shall not relieve 
               Agouron of its obligation to reimburse TSRI for Agouron's half 
               of the aforementioned costs.  TSRI agrees to pay costs 
               associated with maintenance contracts for said Units and shall 
               hold title to said Units.

        5.     Agouron's total contributions herein as described in 
               Paragraphs 1 and 4 above, shall not exceed its one-half share 
               of all costs referenced in the purchase orders and work orders 
               (or contracts) attached hereto as Exhibit C and incorporated 
               by reference herein, plus 5% in the event of cost overruns 
               relating to said purchase orders and work orders, without the 
               written consent of Agouron.

        6.     Upon termination of the Sublease Agreement (Exhibit A hereto), 
               and presuming that all costs relating to the purchase and 
               installation of the Percival Units have been shared equally by 
               both parties hereto, that the purchase price of the Units has 
               been fully paid, and that no invoices or costs relating to 
               said Units remain outstanding or unpaid, disposition of the 
               Percival Units shall be handled as follows.  TSRI and Agouron 
               may each keep two Percival Units for use or 

                                    -2-
<PAGE>

               disposition as each party sees fit.  Alternatively, either 
               TSRI or Agouron may reimburse the other party for its interest 
               in two Units at net book value using straight-line 
               depreciation over five (5) years, thereby keeping all four 
               Units for its own use or disposition.

        7.     All notices or demands of any kind required or desired to be 
               given by TSRI or Agouron hereunder shall be in writing and 
               shall be deemed delivered forty-eight (48) hours after 
               depositing the notice or demand in the United States mail, 
               certified or registered, postage prepaid, addressed to TSRI or 
               Agouron, respectively, at the addresses set forth after their 
               signatures hereinbelow.

        8.     This Agreement sets forth the entire agreement and 
               understanding between the parties as to the subject matter 
               hereof.  There shall be no amendment or modifications to this 
               Agreement, except by a written document which is signed by 
               both parties.

        9.     The relationship between TSRI and Agouron is that of 
               independent contractors.  TSRI and Agouron are not joint 
               venturers, partners, principal and agent, master and servant, 
               employer or employee, and have no other relationship other 
               than independent contracting parties.  TSRI and Agouron shall 
               have no power to bind or obligate each other in any manner, 
               other than as is expressly set forth in this Agreement.

       10.     This Agreement shall be construed and enforced in accordance 
               with the laws of the State of California.

       11.     Should any one or more of the provisions of this Agreement be 
               held invalid or unenforceable by a court of competent 
               jurisdiction, it shall be considered severed from this 
               Agreement and shall not serve to invalidate the remaining 
               provisions thereof.  The parties shall make a good faith 
               effort to replace any invalid or unenforceable provision with 
               a valid and enforceable one such that the objectives 
               contemplated by them when entering this Agreement may be 
               realized.

///

///

///

///

                                    -3-
<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Agreement by their 
duly authorized representatives as of the date set forth above.

TSRI:                                      AGOURON:

THE SCRIPPS RESEARCH INSTITUTE             AGOURON PHARMACEUTICALS, INC.


By:     /s/ DONNA J. WESTON                By:   /s/ GLENN ZINSER
       ----------------------------             ---------------------------
        Donna J. Weston                             Glenn Zinser

Title:  Vice President and                 Title:   VP, Operations
        Chief Financial Officer

10550 N. Torrey Pines Road                 10350 N. Torrey Pines Road
La Jolla, CA 92037                         La Jolla, CA 92037


                                    -4-
<PAGE>




                                   EXHIBIT A



                                   SUBLEASE

<PAGE>



                                                   EXHIBIT 10.66

                            STANDARD FORM LEASE



     This Lease dated October 25, 1996 (this "Lease") is entered into by 
and between Scripps Jack, Ltd., a California limited partnership 
("Landlord") and Agouron Pharmaceuticals, Inc., a California 
corporation ("Tenant").


                                 ARTICLE I.

                          BASIC LEASE PROVISIONS

     Each reference in this Lease to the "Basic Lease Provisions" shall 
mean and refer to the following terms, the application of which shall be 
governed by the provisions in the remaining Articles of this Lease:

1.     Address of Landlord:   Birtcher Property Services
                              27611 La Paz Road, Laguna Niguel, CA 92677 
                              with a copy to Scripps Jack, Ltd., P.O.Box 
                              614, Bloomington, Illinois, 61702, Attn: 
                              Real Estate Services

2.     Premises Address:      4245 Sorrento Valley Boulevard
                              San Diego, Ca  92121

3.     Address of Tenant:

          (a)     Notices:    4245 Sorrento Valley Boulevard
                              San Diego, California, 92121

          (b)     Billing:    Agouron Pharmaceuticals, Inc.
                              10350 North Torrey Pines Road
                              La Jolla, California, 92037-1020

4.     Tenant's Trade Name:   Agouron Pharmaceuticals, Inc.

5.     Tenant's Contact:      Glenn Zinser    Telephone:  (619) 622-3005

6.     Premises Square Footage: Both the Premises and the Building 
       consist of approximately 22,843 square feet of gross building 
      area ("Square Feet of Gross Building Area"). The exact number of 
      Square Feet of Gross Building Area in the Premises and the 
      Building shall be determined as set forth in Section 2.1 below.

7.     Commencement Date:  See Section 3.2

8.     Term:     From the Commencement Date through December 31,2001

9.     Initial Monthly Rent: The initial Monthly Rent payable by Tenant  
       to Landlord shall be One and 45/100 Dollars ($1.45) per square 
       foot per month of Square Feet of Gross Building Area within the
       Premises, subject to adjustment pursuant to Exhibit E attached 
       hereto. Accordingly, the approximate amount of the initial
       Monthly Rent shall be Thirty Three-Thousand One Hundred Twenty
       Two and 35/100 Dollars ($33,122.35).  In the event the Square
       Feet of Gross Building Area in the Premises as determined in
       accordance with Section 2.1 differs from the approximate amount
       of Square Feet of Gross Building Area set forth in Item 6 of the
       Basic Lease Provisions, Landlord and Tenant agree to promptly
       execute an amendment to this Lease which revises the amounts 
       of Minimum Rent provided herein and in Exhibit E.  Additionally,
       to the extent that Tenant has overpaid Monthly Rent for the
       period from the Commencement Date until the end of the month in
       which the determination of the Rentable Square Feet of Floor Area
       of the Premises pursuant to Section 2.1 is made, Landlord shall
       immediately reimburse Tenant therefore. Similarly, to the extent
       that Tenant has underpaid Landlord Monthly Rent for such period,
       Tenant shall immediately pay Landlord such there shall be no
       underpayment.

10.     Security Deposit: $35,000.00

11.     Permitted Uses: Biotech research and development and related 
        pharmaceutical operations, pursuant to approvals to be obtained
        by Tenant from all relevant City, County and other required
        governmental agencies and authorities.

12.     Broker: Landlord's Broker - C.B. Commercial Real Estate Group,
        Inc.
                 Tenant's Broker - Colliers Iliff Thorn

                                      -1-
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13.     Landlord's Architect:  Carrier Design Group, Inc.

14.     Guarantor:  None

15.     Vehicle Parking Spaces:  Seventy (70)

16.     Additional Insureds:  Birtcher Property Services and Scripps  
        Jack, Ltd.

17.     Tenant's Liability Insurance Limits: $10,000,000.00 

18.     Tenant's Share: 100%

Exhibits:

     A     Description of Premises     
     B     Property Description
     C     Work Letter     
     D     Commencement Date Memorandum     
     E     Adjustments to Monthly Rent     
     F     Rules and Regulations
     G     Environmental Questionnaire
+
Riders:

     Rider No.1 to Lease


                              ARTICLE II

                             DEFINITIONS

     2.1     Certain Definitions.  The capitalized terms set forth
 below, unless the context clearly requires otherwise, shall have the
 following meanings in this Lease:

            "Additional Rent" means any and all sums (whether or not 
 specifically called "Additional Rent" in this Lease) other than Monthly
 Rent which Tenant is or becomes obligated to pay to Landlord under this
 Lease.  See also Rent.

            "Alterations" means any alterations, decorations,
 modifications, additions or improvements made in, on, about, under or 
contiguous to the Building or the Premises after the Commencement Date 
ncluding, but not limited to, lighting, HVAC and electrical fixtures,
 pipes and conduits, transfer, storage and disposal facilities, partitions, 
drapery, wall coverings, shelves, cabinetwork, carpeting and other floor 
coverings, ceiling tiles, fixtures and carpentry installations.

          "Applicable Laws" means the laws, rules, regulations, 
ordinances, restrictions, and practices described in Section 5.2.

          "Applicable Rate" means the greater of ten percent (10%) per 
annum or five percent (5%) in excess of the discount rate of the Federal 
Reserve Bank of San Francisco in effect on the twenty-fifth (25th) day of 
the calendar month immediately prior to the event giving rise to the 
Applicable Rate imposition; provided, however, the Applicable Rate shall in 
no event exceed the maximum interest rate permitted to be charged by 
applicable law.

          "Broker" means the person or entity identified in Item 12 of 
the Basic Lease Provisions.

          "Building" means that certain building within which the 
Premises are located.

          "Casualty" is defined in Section 12.1.

          "City" means the city in which the Premises are located.

          "Commencement Date" means the commencement date of the Term, 
described in Section 3.2.

          "Common Area" means all areas and facilities within the Project 
exclusive of the Premises and other portions of the Project leased (or to be 
leased) exclusively to other tenants.  The Common Area includes, but is not 
limited to, parking areas, access and perimeter roads, sidewalk, landscaped 
areas and similar areas and facilities.  Tenant's use of the Common Area, and 

                                      -2-
<PAGE>

its rights and obligations with respect thereto, are more particularly 
described in Article X.

          "County" means the county in which the Premises are located.

          "Event of Default" means the Tenant defaults described in 
Section 15.1.

          "Guarantor" means the person(s) or entity identified in Item 
14 of the Basic Lease Provisions, if any.

          "HVAC" means the heating, ventilating and air conditioning 
system serving the Building.

          "Hazardous Materials" is defined in Section 6.1.

          "Landlord's Agents" means Landlord's authorized agents, 
representatives, property managers (whether as agents or independent 
contractors), consultants, contractors, partners, subsidiaries, affiliates, 
directors, officers and employees, including without limitation the 
Additional Insureds named in Item 16 of the Basic Lease Provisions.

          "Landlord's Architect" means the architect or architectural 
firm from time to time designated by Landlord to perform the function of 
Landlord's Architect set forth in this Lease.  Landlord's Architect 
initially shall be the architect or architectural firm designated in Item 13 
of the Basic Lease Provisions.

          "Lease" means this instrument together with all exhibits, 
amendments, addenda and riders attached hereto and made a part hereof.

          "Monthly Rent" means the monthly rental which Tenant is to pay 
to Landlord pursuant to Section 4.1, as the same may be adjusted from time 
to time as set forth in this Lease.  See also Rent.

          "Mortgage" means any mortgage, deed of trust, or similar lien 
on or covering the Project or any part thereof.

          "Mortgagee" means any mortgagee of a mortgage, beneficiary of 
a deed of trust or lender having a lien on or covering the Project or any 
part thereof.

          "Notice" means each and every notice, communication, request, 
demand, reply or advice, or duplicate thereof, in this Lease provided or 
permitted to be given, made or accepted by either party to any other party, 
which shall be in writing and given in accordance with the provisions of 
Section 21.6.

          "Operating Expenses" means, collectively, Project Costs and 
Real Property Taxes.

          "Plans" means the final working drawings for the construction 
of the Tenant Improvements to be prepared and approved as set forth in the 
Work Letter.

          "Outside Areas" means the areas outside the exterior walls of 
the Building.

          "Premises" means the premises shown in Exhibit A, and all 
areas appurtenant thereto, if any, for the exclusive use of Tenant, as shown 
in ExhibitA.  The Premises are located within and constitute the Building 
at the address set forth in Item 2 of the Basic Lease Provisions.

          "Premises Square Footage"  means the floor area of both the 
Premises and the Building.  Upon substantial completion of the Premises, 
Landlord's architect or another appropriate professional shall certify the 
total Square Feet of Gross Building Area in the Premises and the Building 
based upon the BOMA Gross Building Area standard of measurement.

          "Project" means that certain real property, and all 
improvements thereon, including the Building and other buildings, if any, 
located within the boundaries of such property, described in the Property 
Description. 

          "Project Costs" is defined in Section 7.3.
 
          "Property Description" means Exhibit B.

          "Real Property Taxes" is defined in Section 7.4.

                                     -3-
<PAGE>

          "Rent" means Monthly Rent and Additional Rent, collectively.

          "Rules and Regulations" means the rules and regulations 
attached hereto as Exhibit F and any modifications thereto promulgated by 
Landlord or Landlord's Agents from time to time.

          "Security Deposit" means the amount set forth in Item 10 of 
the Basic Lease Provisions, which shall be paid to Landlord by Tenant 
pursuant to Section 4.6.

          "Substantial Completion" and "substantially completed" 
means the date on which the repair of the Premises following a Casualty, 
have been fully completed except for minor details of construction, 
mechanical adjustments or decoration which do not materially interfere with 
Tenant's use and enjoyment of the Premises (items normally referred to as 
"punch list" items).

          "Tenant Delays" means any and all delays due to the fault of 
the Tenant, but only to the extent caused by such default, including without 
limitation Tenant's failure to deliver to Landlord prior to the Commencement 
Date, executed copies of policies of insurance or certificates thereof as 
required under Section 11.8.

          "Tenant Improvements" means those certain improvements, if 
any, to be constructed on the Premises as provided in Article XX and in the 
Work Letter.

          "Tenant's Agents" means Tenant's agents, representatives, 
consultants, contractors, affiliates, subsidiaries, officers, directors, 
employees, subtenants, guests and invitees.

          "Tenant's Personal Property" means Tenant's removable trade 
fixtures, furniture, equipment and other personal property located in or on 
the Premises.

          "Term" means the term of this Lease, as provided in Section 
3.2.

          "Unavoidable Delay" means any delays which are beyond a 
party's reasonable control including, but not limited to, delays due to 
inclement weather, strikes, acts of God, inability to obtain labor or 
materials, inability to secure governmental approvals or permits, 
governmental restrictions, civil commotion, fire, earthquake, explosion, 
flood, hurricane, the elements, or the public enemy, action or interference 
of governmental authorities or agents, war invasion, insurrection, 
rebellion, riots, lockouts or any other cause whether similar or dissimilar 
to the foregoing which is beyond a party's reasonable control; provided 
however, that in no event shall any of the foregoing ever apply with respect 
to the payment of any monetary obligation.

          "Work Letter" means the work letter between Landlord and 
Tenant regarding the construction of the Tenant Improvements, if any, in the 
form of Exhibit C.

     2.2     Other Definitions.  Terms defined elsewhere in this Lease, 
unless the context clearly requires otherwise, shall have the meaning as 
there given.


                               ARTICLE III

                            PREMISES AND TERM

     3.1     Lease of Premises.  Subject to and upon the terms and 
conditions set forth herein, Landlord hereby leases the Premises to Tenant, 
and Tenant hereby leases the Premises from Landlord.

     3.2     Terms and Commencement.  Unless sooner terminated as 
provided herein, the Term of this Lease shall be for that period of years 
and months set forth in Item 8 of the Basic Lease Provisions, as the same may 
be extended in accordance with any option or options to extend the Term 
granted herein, and shall commence (the "Commencement Date") on the earlier 
of (i) the later to occur of May 15,1997 or two-hundred ten (210) days after 
Landlord delivers possession of the Premises to Tenant or (ii) the date that 
Tenant is issued a certificate of occupancy or temporary certificate of 
occupancy by the City of San Diego.  When the actual Commencement Date has 
occurred, Landlord and Tenant shall execute a Commencement Date Memorandum 
in the form shown in Exhibit D.  

                                     -4-
<PAGE>

     3.3     Early Entry. Tenant and its authorized agents, contractors, 
subcontractors and employees shall be granted a license by Landlord to enter 
upon the Premises, at Tenant's sole risk and expense, during ordinary 
business hours prior to the Commencement Date, for the sole purpose of 
installing Tenant's trade fixtures and equipment in the Premises; provided, 
however, that (i) the provisions of this Lease, other than with respect to 
the payment of Monthly Rent, shall apply during such early entry including, 
but not limited to, the provisions of Article XI relating to Tenant's 
indemnification of Landlord, (ii )prior to any such entry, Tenant shall pay 
for and provide evidence of the insurance to be provided by Tenant pursuant 
to the provisions of Article XI, (iii) Tenant shall pay all utility, service 
and maintenance charges for the Premises attributable to Tenant's early 
entry and use of the Premises as reasonably determined by Landlord, (iv) 
Tenant shall not unreasonably interfere, delay or hinder Landlord, its 
agents, contractors or subcontractors in the construction of the Tenant 
Improvements in accordance with the provisions of this Lease, and (v) Tenant 
shall not use the Premises for the storage of inventory or otherwise 
commence the operation of business during the period of such early entry.  
Upon Tenant's breach of any of the foregoing conditions, Landlord may, in 
addition to exercising any of its other rights and remedies set forth 
herein, revoke such license upon notice to Tenant.  Early entry by Tenant in 
accordance with this Section 3.3 shall not constitute occupancy of the 
Premises for purposes of establishing the Commencement Date.

     3.4     Delay in Possession.  If for any reason Landlord cannot 
deliver possession of the Premises to Tenant on or before the Commencement 
Date, Landlord shall not be subject to any liability therefor, and such 
failure shall not affect the validity of this Lease or the obligations of 
Tenant hereunder, but in such case, Tenant shall not be obligated to pay 
Monthly Rent or Additional Rent other than as provided in Section 3.3 and 
Section 3.5 until the Commencement Date as defined in Section 3.2 above, has 
occurred.  If Landlord does not deliver possession of the Premises to Tenant 
within ten (10) days following the full execution of the Lease by Landlord 
and Tenant plus periods attributable to Tenant Delays or Unavoidable Delay, 
Tenant may, at its option, by Notice to Landlord within ten (10) days 
thereafter, terminate this Lease, in which event the parties shall be 
discharged from all further obligations hereunder; provided, however, if 
Tenant fails to give such notice to Landlord within such ten-day period, 
Tenant shall no longer have the right to terminate this Lease under this 
Section 3.4.  Tenant understands that, notwithstanding anything to the 
contrary contained herein, Landlord shall have no obligation to deliver 
possession of the Premises to Tenant for so long as Tenant fails to deliver 
to Landlord executed copies of policies of insurance or certificates thereof 
as required under Section 11.8.

     3.5     Tenant Delays.  The Commencement Date shall not be delayed or 
postponed due to Tenant Delays, and the Term, Tenant's obligations to pay 
Rent and all of Tenant's other obligations under this Lease shall commence 
upon the date which would have been the Commencement Date but for Tenant 
Delays.

     3.6     Condition of Premises.  Landlord's sole construction 
obligations, if any, regarding Tenant Improvements for the Premises are set 
forth in Article XX and the Work Letter.  The taking of possession or use of 
the Premises by Tenant for any purpose other than as provided in Section 3.3 
shall conclusively establish that Tenant has inspected the Premises and 
accepts them as being in good and sanitary order, condition and repair, 
except for latent structural structural defects and Landlord's maintenance 
obligations set forth in Article IX.

     3.7     No Representations.  Tenant acknowledges that neither 
Landlord nor any of Landlord's Agents has made any representations or 
warranties as to the suitability or fitness of the Premises for the conduct 
of Tenant's business including, but not limited to, any representations or 
warranties regarding zoning or other land use matters, or for any other 
purpose, and that neither Landlord nor any of Landlord's Agents has agreed 
to undertake any alterations or additions or construct any Tenant 
Improvements to the Premises except as expressly provided in this Lease. 
Landlord is not aware of any restrictions that would adversely affect the 
Permitted Uses contemplated in this Lease.


                                  ARTICLE IV

                             RENT AND ADJUSTMENTS

     4.1     Monthly Rent.  From and after the Commencement Date, Tenant 
shall pay to the Landlord, for each calendar month of the Term, the Monthly 
Rent set forth in Item 9 of the Basic Lease Provisions, as the same may be 
adjusted from time to time as provided in Section 4.2.  Monthly Rent shall be 

                                      -5-
<PAGE>

due and payable to Landlord in lawful money of the United States, in 
advance, on the first (1st) day of each calendar month of the Term, without 
abatement, deduction, claim or offset, and without prior notice, invoice or 
demand, at Landlord's address set forth in Item 1 of the Basic Lease 
Provisions or at such place as Landlord may from time to time designate.  
Tenant's payment of Monthly Rent for the first (1st) month of the Term shall 
be delivered to Landlord concurrently with Tenant's execution of this Lease.

     4.2     Adjustments.  Monthly Rent shall be adjusted from time to time 
as provided in ExhibitE.

     4.3     Additional Rent.  All Additional Rent shall be due and payable 
to Landlord in lawful money of the United States, at Landlord's address set 
forth in Item 1 of the Basic Lease Provisions or at such other place as 
Landlord may from time to time designate, without abatement, deduction, 
claim or offset, within ten (10) days of receipt of Landlord's invoice or 
statement for same, or if this Lease provides another time for the payment 
of certain items of Additional Rent, then at such other time.

     4.4     Prorations.  If the Commencement Date is not the first (1st) 
day of a month, or if the expiration of the Term of this Lease is not the 
last day of a month, a prorated installment of Monthly Rent based on a 
thirty (30) day month shall be paid for the fractional month during which 
the Term commences or terminates.

     4.5     Late Payment Charges.  Tenant acknowledges that late payment 
by Tenant to Landlord of Rent under this Lease will cause Landlord to incur 
costs not contemplated by this Lease, the exact amount of which is extremely 
difficult or impracticable to determine.  Such costs include, but are not 
limited to, processing and accounting charges, late charges that may be 
imposed on Landlord by the terms of any Mortgage, and late charges and 
penalties that may be imposed due to late payment of Real Property Taxes.  
Therefore, if any installment of Monthly Rent or any payment of Additional 
Rent due from Tenant is not received by Landlord in good funds by the tenth 
(10) calendar day from the applicable due date, Tenant shall pay to Landlord 
an additional sum equal to the lesser of One Thousand Dollars ($1,000.00) or 
three percent (3%) of the amount overdue as a late charge for every month or 
portion thereof that such amount remains unpaid.  The parties acknowledge 
that this late charge presents a fair and reasonable estimate of the costs 
that Landlord will incur by reason of the late payment by Tenant.  
Acceptance of any late Rent and late charge therefor shall not prevent 
Landlord from exercising any of the other rights and remedies available to 
Landlord for any other Event of Default under this Lease.  Notwithstanding 
the foregoing (i) should any payment of Rent by personal check be rejected 
for insufficient funds, Landlord shall have the right, upon notice to 
Tenant, to require that all future payments by Tenant under this Lease be by 
cashier's check acceptable to Landlord, and (ii)upon the third (3rd) 
occurrence during the Term of Tenant's failure to timely pay Rent when due, 
Landlord may, upon notice to Tenant, require that Monthly Rent for the 
balance of the Term be made in quarterly installments, in advance, in an 
amount equal to the sum of the Monthly Rent amounts payable during such 
three (3) month period.

     4.6     Security Deposit.  Tenant has deposited with Landlord the sum 
set forth in Item 10 of the Basic Lease Provisions as a Security Deposit for 
the full and faithful performance of every provision of this Lease to be 
performed by Tenant. Upon an uncured Event of Default, and whether or not 
Landlord is informed of or has knowledged of the event of Default, the 
Security Deposit shall be deemed to be automatically applied, without waiver 
of any rights Landlord may have under this Lease or at law or in equity as a 
result of an Event of Default, to the payment of any Rent not paid when due, 
the repair of damage to the Premises or the payment of any other amount 
which Landlord may spend or become obligated to spend by reason of an Event 
of Default, to the full extent permitted by law.  If any portion of the 
Security Deposit is so applied, Tenant shall, within ten (10) days after 
written demand therefor, deposit cash with Landlord in an amount sufficient 
to restore the Security Deposit to its original amount.  Landlord shall not 
be required to keep the Security Deposit separate from its general funds.  
The unused portion of the Security Deposit, if any, shall be returned to 
Tenant within thirty (30) days of the expiration of this Lease or any 
termination of this Lease not resulting from an Event of Default, so long as 
Tenant has vacated the Premises in the manner required by this Lease and 
paid all sums required to be paid under this Lease, provided however, that 
Landlord may retain the Security Deposit until such time as any amounts of 
Additional Rent due from Tenant have been determined and paid in full.  
Tenant hereby waives the provisions of Section 1950.7(c) of the California 
Civil Code and any present or future laws otherwise governing the return of 
the Security Deposit to Tenant to the extent of reasonably anticipated 
Additional Rent retained by Landlord pursuant to the previous sentence.

                                      -6-
<PAGE>

                                   ARTICLE V

                                     USE

     5.1     Tenant's Use.  Tenant shall use the Premises solely for the 
purposes set forth in Item 11 of the Basic Lease Provisions and shall use the 
Premises for no other purpose.  Tenant's use of the Premises shall be 
subject to all of the terms and conditions of this Lease including, but not 
limited to, all the provisions of this Article V.  Tenant, at Tenant's sole 
cost and expense, shall procure, maintain and make available for Landlord's 
inspection throughout the Term, all governmental approvals, licenses and 
permits required for the proper and lawful conduct of Tenant's permitted use 
of the Premises.  At Landlord's request, Tenant shall deliver copies of all 
such approvals, licenses and permits to Landlord.

     5.2     Compliance With Applicable Laws.  Throughout the Term, 
Tenant, at Tenant's sole cost and expense, shall comply with, and shall not 
use the Premises, Building or Common Area, or suffer or permit anything to 
be done in or about the same which will in any way conflict with, (i) any 
and all present and future laws, statutes, zoning restrictions, ordinances, 
orders, regulations, directions, rules and requirements of all governmental 
or private authorities having jurisdiction over all or any part o the 
Premises (including, but not limited to, state, municipal, county and 
federal governments and their departments, bureaus, boards and officials) 
pertaining to the use or occupancy of, or applicable to, the Premises or 
privileges appurtenant to or in connection with the enjoyment of the 
Premises, (ii)any and all applicable federal, state and local laws, 
regulations or ordinances pertaining to air and water quality, Hazardous 
Materials (as defined in Section 6.1), waste disposal, air emissions and 
other environmental or health and safety matters, zoning, land use and 
utility availability, which impose any duty upon Landlord or Tenant directly 
or with respect to the use or occupation of the Project or any portion 
thereof, (iii) the requirements of the Board of Fire Underwriters or other 
similar body now or hereafter constituted relating to or affecting the 
condition, use or occupancy of the Project or any portion thereof, (iv) any 
covenants, conditions, easements or restrictions now or hereafter affecting 
or encumbering the Project or any portion thereof, regardless of when they 
become effective, (v) the Rules and Regulations, and (vi) good business 
practices (collectively, (i) through (vi) above are hereinafter referred to 
as "Applicable Laws").  Tenant shall not commit any waste of the Premises, 
Building or Project, or any public or private nuisance or any other act or 
thing which might or would disturb the quiet enjoyment of any other tenant 
of Landlord or any occupant of nearby property.  Tenant shall not place or 
permit to be placed any loads upon the floors, walls or ceilings in excess 
of the maximum designed load specified by Landlord or which might damage the 
Premises or the Building, or place or permit to be placed any liquids in 
levels in excess of applicable laws or regulations in the drainage systems, 
and Tenant shall not dump or store, or permit to be dumped for stored, any 
inventory, waste materials, refuse or other materials or allow any such 
materials to remain outside the Building proper, except in designated 
enclosed trash areas.  Tenant shall not conduct or permit any auctions, 
sheriff's sales or other like activities at the Project or any portion 
thereof.

     5.3     Restrictions. Tenant agrees that it will subordinate this 
Lease to any other covenants, conditions and restrictions and any reciprocal 
easement agreements or any similar agreements which Landlord may hereafter 
record against the Premises and to any amendment or modification to any of 
the existing Restrictions, provided that such subordination does not 
unreasonably interfere with Tenant's use and enjoyment of the Premises, 
adversely affect Tenant's rights, or increase the monetary or other 
obligations of Tenant under this Lease.

     5.4     Landlord's Right of Entry.  Landlord and Landlord's Agents 
shall have the right to enter the Premises at all reasonable times upon 
reasonable notice to Tenant, except for emergencies in which case no notice 
shall be required, to inspect the Premises, to take samples and conduct 
environmental investigations, to post notices of nonresponsibility and 
similar notices and signs indicating the availability of the Premises for 
sale, to show the Premises to interested parties such as prospective lenders 
and purchasers, to make necessary Alterations or maintenance and repairs, to 
perform Tenant's obligations as permitted herein when Tenant has failed to 
do so and, at any reasonable time after one hundred eighty (180) days prior 
to the expiration of the Term, to place upon the Premises reasonable signs 
indicating the availability of the Premises for lease and to show the 
Premises to prospective tenants, all without being deemed to have caused an 
eviction of Tenant and without any liability to Tenant or abatement of Rent.  
The above rights are subject to reasonable security regulations of Tenant, 
and in exercising its rights set forth herein, Landlord shall endeavor to 
cause the least possible interference with Tenant's business.  Landlord 

                                      -7-
<PAGE>

shall at all times have the right to retain a key which unlocks all of the 
doors in the Premises, excluding Tenant's vaults and safes, and Landlord and 
Landlord's Agents shall have the right to use any and all means which 
Landlord may deem proper to open the doors in an emergency to obtain entry 
to the Premises, and any entry to the Premises so obtained by Landlord or 
Landlord's Agents shall not be deemed to be a forcible or unlawful entry 
into, or a detainer of, the Premises, or an eviction of Tenant from the 
Premises if conducted reasonably in accordance with the terms of this Lease.


                                   ARTICLE VI

                              HAZARDOUS MATERIALS

     6.1     Definition of Hazardous Materials.  For purposes of this 
Lease, the term "Hazardous Materials" includes (i) any "hazardous materials" 
as defined in Section 25501(k) of the California Health and Safety Code 
unless Tenant establishes, to the satisfaction of Landlord, that because of 
the quantity, concentration, or physical or chemical characteristics, such 
substance or matter does not pose a present or potential hazard to human 
health and safety or to the environment, (ii) any other substance or matter 
which results in liability to any person or entity from exposure to which 
substance or matter under any statutory or common law theory, and (iii) any 
substance or matter which is in excess of relevant and appropriate levels 
set forth in any applicable federal, state or local law or regulation 
pertaining to any hazardous or toxic substance, material or waste, or for 
which any applicable federal, state or local agency orders or otherwise 
requires removal, treatment or remediation.

     6.2     Prohibition/Compliance.  Tenant shall not cause or permit 
any Hazardous Material (as hereinafter defined) to be brought upon, kept or 
used in or about the Premises or the Project in violation of applicable law 
by  Tenant, its agents, employees, contractors or invitees.  If Tenant 
breaches the obligation stated in the preceding sentence, or if the presence 
of Hazardous Materials results in unlawful contamination of the Premises, 
the Building, the Project or any adjacent property or if unlawful 
contamination of the Premises, the Building, the Project or any adjacent 
property by Hazardous Material otherwise occurs during the term of this 
Lease or any extension or renewal hereof or holding over hereunder, then 
Tenant shall indemnify, defend and hold Landlord, its agents and contractors 
harmless from any and all claims, judgments, damages penalties, fines, 
costs, liabilities or losses (including without limitation diminution in 
value of the Premises or any portion of the Project, damages for the loss or 
restriction on use of rentable or usable space or of any amenity of the 
Premises or Project, damages arising from any adverse impact on marketing of 
space in the Premises or the Project, and sums paid in settlement of claims, 
attorneys' fees, consultant fees and expert fees) which arise during or 
after the Lease term as a result of such contamination.  For the purpose of 
this Section 6.2, unlawful contamination is Hazardous Material which 
violates any applicable local, state or federal laws or any regulations or 
standards promulgated thereunder, including requirements or standards 
imposed by any governmental agency or by governmental order or court having 
jurisdiction over the Project.  This indemnification of Landlord by Tenant 
includes, without limitation, costs incurred in connection with any 
investigation of site conditions of any cleanup, remedial, removal, or 
restoration work required by any federal, state or local governmental agency 
or political subdivision because of Hazardous Material present in the air, 
soil or ground water above on or under the Premises.  Without limiting the 
foregoing, if the presence of any Hazardous Material on the Premises, the 
Building, the Project or any adjacent property, caused or permitted by 
Tenant results in any unlawful contamination of the Premises, the Building, 
the Project or any adjacent property, Tenant shall promptly take all actions 
at its sole expense as are necessary to ensure the Premises, the Building, 
the Project or any adjacent property meets all applicable local, state and 
federal laws and any regulations or standards promulgated thereunder, in 
effect now or in the future, including requirements by any governmental 
agency or imposed by any governmental order or court having jurisdiction 
over the project, provided that Landlord's approval of such action shall 
first be obtained, which approval shall not unreasonably be withheld so long 
as such actions would not potentially have any material adverse long-term or 
short-term effect on the Premises, the Building or the Project.

     6.3     Business.  Landlord acknowledges that it is not the intent of 
this Article 6 to prohibit Tenant from operating its business as described 
in Item 11 of the Basic Lease Provisions above.  Tenant may operate its 
business according to the custom of the industry so long as the use or 
presence of Hazardous Material is strictly and properly monitored according 
to all applicable governmental requirements.  As a material inducement to 
Landlord to allow Tenant to use Hazardous Material in connection with its 
business, Tenant agrees to deliver to Landlord prior to the Commencement 
Date a list identifying each type of Hazardous Material to  be present on 

                                  -8-
<PAGE>

the Premises and setting forth any and all governmental approvals or permits 
required in connection with the presence of such Hazardous Material on the 
Premises ("Hazardous Material List"). Tenant shall deliver to Landlord an 
updated Hazardous Material List at least once a year.  Tenant shall deliver 
to Landlord true and correct copies of the following documents (hereinafter 
referred to as the "Documents") relating to the handling, storage, disposal 
and emission of Hazardous Material prior to the Commencement Date, or if 
unavailable at the time, concurrent with the receipt from or submission to a 
governmental agency:  permits; approvals; reports and correspondence; 
storage and management plans, notice of violations of any laws; plans 
relating to the installation of any storage tanks to be installed in or 
under the Project (provided, said installation of tanks shall only be 
permitted after Landlord has given Tenant its written consent to do so, 
which consent may be withheld in Landlord's sole and absolute discretion); 
and all closure plans or any other documents required by any and all 
federal, state and local governmental agencies and authorities for any 
storage tanks installed in, on or under the Project for the closure of any 
such tanks.  Tenant is not required, however, to provide Landlord with any 
portion(s) of the Documents containing information of a proprietary nature 
which, in and of themselves, do not contain a reference to any Hazardous 
Material or hazardous activities.  It is not the intent of this Section to 
provide Landlord with information which could be detrimental to Tenant's 
business should such information become possessed by Tenant's competitors.

     6.4     Termination of Lease.  Notwithstanding the provisions of 
Section 6.2 above, if Tenant or the proposed assignee or sublessee is 
subject to an enforcement order issued by any governmental authority in 
connection with the use, disposal or storage of a Hazardous Material at the 
Project, Landlord shall have the right to terminate the Lease in  Landlord's 
sole and absolute discretion (with respect to any such matter involving 
Tenant) and it shall not be unreasonable for Landlord to withhold its 
consent to any proposed assignment or subletting (with respect to any such 
matter involving a proposed assignee or sublessee).

     6.5     Testing.  At reasonable times, and from time to time, prior to 
the expiration of the Term Landlord shall have the right at its own expense 
to conduct appropriate investigations and tests of the Premises, Building 
and Project to demonstrate that unlawful contamination has occurred as a 
result of Tenant's use of the Premises.  Tenant shall be responsible for the 
cost of any investigations and tests which indicate that unlawful 
contamination resulted from Tenant's use of the Premises.  Tenant shall be 
solely responsible for and shall defend, indemnify and hold the Landlord, 
its agents and contractors harmless from an against any and all claims, 
costs and liabilities including actual attorneys' fees and costs, arising 
out of or in connection with any removal, clean up, restoration and 
materials required hereunder to ensure the Premises and any other property 
of whatever nature, meets all applicable local, state and federal laws and 
any regulations or standards promulgated thereunder, in effect now or in the 
future, including requirements by any governmental agency or imposed by any 
governmental order or court having jurisdiction over the project.  Tenant 
shall pay for the cost of a third party prepared Phase I exit audit of the 
Premises at the termination of the Leases plus the cost of any tests or 
remediations reasonably recommended in said audit to bring any Tenant caused 
contamination to meet all applicable local, state and federal laws and any 
regulations or standards promulgated thereunder, in effect now or in the 
future, including requirements by any governmental agency or imposed by any 
governmental order or court having jurisdiction over the Project.

     6.6     Tenant's Responsibility at Conclusion of Lease.  
Promptly upon the expiration or sooner termination of this Lease, Tenant 
shall certify to Landlord in writing that (i)Tenant has made a diligent 
effort to determine whether any Hazardous Materials are on, under or about 
the Premises as a result of any acts or omissions or Tenant or Tenant's 
Agents and (ii)no such Hazardous Materials exist on, under or about the 
Premises other than as specifically identified to Landlord by Tenant in 
writing.  In addition, Tenant shall provide Landlord with independent 
verification (acceptable to Landlord) that (i) all permits, reports, closure 
or decertification procedures, if applicable, have been secured or satisfied 
by Tenant for its discontinuance of use of the Premises under this Lease and 
(ii) the interior of the Premises is free of contamination by Hazardous 
Materials.  If Tenant or its independent verification discloses the 
existence of Hazardous Materials on, under or about the Premises, or if 
Landlord at any time discovers that Tenant or Tenant's Agents caused or 
permitted the release of a Hazardous Material on, under, from or about the 
Premises, Tenant shall, at Landlord's request, immediately prepare and 
submit to Landlord within thirty (30) days after such request a 
comprehensive plan, subject to Landlord's approval, specifying the actions 
to be taken by Tenant to return the Premises to the condition existing prior 
to the introduction of such Hazardous Materials.  Upon Landlord's approval 
of such cleanup plan, Tenant shall, at Tenant's sole cost and expense, 
without limitation on any rights and remedies of Landlord under this Lease 

                                  -9-
<PAGE>

or at law or in equity, immediately implement such plan and proceed to clean 
up such Hazardous Materials in accordance with all Applicable Laws and as 
required by such plan and this Lease.


                                  ARTICLE VII

                    OPERATING EXPENSES; TAXES; UTILITIES

     7 1. Payment of Maintenance Expenses.  Prior to the Commencement Date 
and thereafter prior to the commencement of each of Landlord's fiscal years 
during the Term, Landlord shall give Tenant a written estimate based on 
generally accepted accounting principles of Maintenance Expenses (hereafter 
defined) for the ensuing fiscal year or partial fiscal year as the case may 
be. Tenant shall pay, as an item of Additional Rent such estimated amount in 
equal monthly installments, in advance, on or before the first (1st) day of 
each calendar month concurrent with its payment of Monthly Rent. If Landlord 
has not furnished its written estimate by the time set forth above, Tenant 
shall pay monthly installments of Maintenance Expenses at the rate 
established for the prior fiscal year, if any; provided that when the new 
estimate is delivered to Tenant, Tenant shall (provided it is given not less 
than thirty (30) days prior written notice) at the next monthly payment date 
pay Landlord any accrued deficiency based on the new estimate, or Landlord 
shall credit any accrued overpayment based on such estimate toward Tenant's 
next installment payment hereunder.  Within a reasonable period of time 
after the end of each fiscal year (in no event more than one hundred (120) 
days after the end of each fiscal year unless sooner completed by Landlord) 
Landlord shall furnish Tenant a statement showing in reasonable detail the 
actual Maintenance Expenses incurred for the period in question. If Tenant's 
estimated payments are less than the actual Maintenance Expenses as shown by 
the applicable statement, Tenant shall pay the difference to Landlord within 
thirty (30) days thereafter. If Tenant shall have overpaid Landlord, 
Landlord shall credit such overpayment toward Tenant's next installment 
payment hereunder or if in the last year of the Lease Term and at Tenant's 
option, refund such overpayment within 30 days thereafter.  When the final 
determination is made of the actual Maintenance Expenses for the fiscal year 
in which this Lease terminates, Tenant shall, even if this Lease has 
terminated, pay to Landlord within thirty (30) days after notice the excess 
of such actual Maintenance Expenses over the estimate of Maintenance 
Expenses paid. Conversely, any overpayment shall be rebated by Landlord to 
Tenant within 30 days. If Landlord shall determine at any time that the 
estimate of Maintenance Expenses for the current fiscal year is or will 
become inadequate to meet all such Maintenance Expenses for any reason, 
Landlord shall immediately determine the approximate amount of such 
inadequacy and issue a supplemental estimate based on generally accepted 
accounting principles as to such Maintenance Expenses and Tenant shall pay 
any increase as reflected by such supplemental estimate, provided it is 
given not less than 20 days prior written notice. Landlord shall keep or 
cause to be kept separate and complete books of accounting covering all 
Maintenance Expenses, and shall preserve for at least twenty-four (24) 
months after the close of each fiscal year all material documents evidencing 
said Maintenance Expenses for that fiscal year. Tenant, at its sole cost and 
expense, through any certified public accountant designated by it, or by 
Tenant's or Tenant's parents financial analysis department, shall have the 
right, during reasonable business hours and not more frequently than twice 
during any fiscal year, to examine and/or audit the books and documents 
mentioned above evidencing such costs and expenses for the previous fiscal 
year. Any delay or failure by Landlord in delivering any estimate or 
statement pursuant to this Section 7.1 shall not constitute a waiver of its 
right to require Tenant to pay all Maintenance Expenses pursuant hereto, 
unless such failure continues for a period in excess of twelve (12) months.

     7.2 Definition of Maintenance Expenses. The term "Maintenance 
Expenses" means all reasonable direct costs and expenses incurred by 
Landlord or Landlord's Agents in connection with the operation, maintenance 
and repair of the Outside Areas, including, but not limited to, the 
following: actual costs and expenses incurred in connection with labor and 
materials utilized in the performance of Landlord's maintenance and repair 
obligations pursuant to Section 9.1; any and all assessments levied against 
the Premises or the Common Area, water, electrical and other utility 
services supplied directly to the Building and Common Area, removal of 
trash, rubbish and other refuse from the Outside Areas and Common Area, 
cleaning of and replacement of signs of the Outside Areas and Common Area, 
including revamping and repairs made as reasonably required; repair, 
operation and maintenance of the Common Area, including, but not limited to, 
removal of any obstructions not reasonably required for the Common Area 
uses, prohibition and removal of the sale or display of merchandise or the 
storing of materials and/or equipment in the Common Area, and payment of all 
electrical, water and other utility charges or fees for services furnished 
to the Common Area and Outside Areas; obtaining and maintaining public 
liability, property damage and other forms of insurance which Landlord may 
or is required to maintain in connection with the Building and the Common 
Area (including the payment of any deductibles thereunder); costs incurred 

                                  -10-
<PAGE>

in connection with Tenant's compliance of any laws or changes in laws 
regarding Hazardous Materials; equipment and supplies; employment of such 
personnel as Landlord may deem reasonably necessary, if any, to direct 
parking and police the Common Area and facilities; the cost of any capital 
improvements (other than tenant improvements for specific tenants) 
specifically benefitting Tenant and made by or on behalf of Landlord to the 
Outside Areas or Common Area to the extent of the amortized amount thereof 
over the useful life of such capital improvements calculated at a market 
cost of funds, all as reasonably determined by Landlord using generally 
accepted accounting principles, for each such year of useful life during the 
Term; depreciation amortized over the longest useful life permitted under 
the Internal Revenue Code of machinery and equipment used in connection with 
the maintenance and operation of the Outside Areas or the Common Area for 
which a reasonable reserve has not been established as herein provided; 
employment of personnel used in connection with any of the foregoing, 
including, but not limited to, payment or provision for unemployment 
insurance, workers' compensation insurance and other employee costs; the 
actual cost of any Environmental consultant or other services used in 
connection with Landlord's monitoring of the Project with respect to 
Hazardous Materials (such costs shall not exceed $1,000.00 per calendar 
year); the cost of any tax, insurance or other consultant utilized in 
connection with the Project; and any other items reasonably necessary from 
time to time to properly repair, replace, maintain and operate the Outside 
Areas or the Common Area.  If Landlord elects to perform any maintenance or 
repair herein described in conjunction with properties other than the 
Project, and if a common maintenance contractor is contracted with for such 
purpose, the contract amount allocable to the Project, as reasonably 
determined by Landlord, shall be added to and deemed a part of Maintenance 
Expenses hereunder. Increases in Maintenance Expenses by reason of a 
disproportionate impact by Tenant thereon (for example, and not by way of 
limitation, increases in costs of trash collection because of Tenant's 
excessive generation of trash or increases in costs of Outside Areas or 
Common Area maintenance because of Tenant's unpermitted storage of inventory 
or materials in the Outside Areas or Common Area), in Landlord's reasonable 
judgment, may be billed by Landlord, as an item of Additional Rent, directly 
to Tenant.

     7.3 Payment of Real Property Taxes.  Landlord shall pay, at Tenant's 
expense and subject to reimbursement by Tenant as hereinafter set forth, all 
Real Property Taxes (as hereinafter defined) levied against the Premises 
during the Term and any Real Property Taxes which have accrued during the 
Term.  The amount of such payments by Landlord shall be based on tax bills 
and notices received by Landlord pertaining to the Premises (and if Tenant 
receives any such tax bills or notices, Tenant shall immediately forward 
same to Landlord) and such payment shall be made before the last day such 
Real Property Taxes are payable without penalty. Tenant shall reimburse to 
Landlord, as an item of Additional Rent, the full amount of such Real 
Property Taxes paid by Landlord within thirty (30) days after Landlord's 
statement or invoice therefor, which statement or invoice shall be 
accompanied by reasonable evidence of the amount of such Real Property 
Taxes. Real Property Taxes shall not include any late charges, penalties or 
interest attributable to Landlord's late payment (other than caused solely 
by Tenant) or any charges, assessments or levies attributable to another 
tenant or another tenant's improvements.

     7.4     Definition of Real Property Taxes.  The term "Real Property 
Taxes" means any form of tax, assessment, charge, license, fee, rent tax, 
levy, penalty (if a result of Tenant's delinquency), real property or other 
tax (other than Landlord's net income, estate, succession, inheritance, or 
franchise taxes), now or hereafter imposed with respect to the Project or 
any part thereof (including any alterations), this Lease or any Rent payable 
under this Lease by any authority having the direct or indirect power to 
tax, or by any city, county, state or federal government or any improvement 
district or other district or division thereof, whether such tax or any 
portion thereof (i)is determined by the area of the Project or any part 
thereof or the Rent payable under this Lease by Tenant including, but not 
limited to, any gross income or excise tax levied by any of the foregoing 
authorities with respect to receipt of the Rent due under this Lease, (ii)is 
levied or assessed in lieu of, in substitution for, or in addition to, 
existing or additional taxes with respect to the Project or any part thereof 
whether or not now customary or within the contemplation of Landlord or 
Tenant, or (iii)is based upon any legal or equitable interest of Landlord in 
the Project or any part thereof.

     7.5     Apportionment of Taxes.  If the Project is assessed as part 
of a larger parcel, then Landlord shall equitably apportion the Real 
Property Taxes assessed against the real property, which includes the 
Project and reasonably determine the amount of Real Property Taxes 
attributable to the Project.  If other buildings exist on the assessed 
parcel, the Real Property Taxes apportioned to the Project shall be based 
upon the ratio of the square footage of all buildings within the Project to 
the square footage of all buildings on the assessed parcel, and the amount 

                                  -11-
<PAGE>

of Real Property Taxes so apportioned to the Project shall be included as 
part of Operating Expenses.  Landlord's reasonable determination of such 
apportionment shall be conclusive.

     7.6     Tax on Improvements; Permitted Contests.  Tenant shall, at 
Landlord's election, be directly responsible for and shall pay the full 
amount of any increase in Real Property Taxes attributable to any and all 
Tenant Improvements and any other improvements of any kind whatsoever placed 
in, on or about the Premises for the benefit of, at the request of, or by 
Tenant.  Tenant may contest the amount or validity of any Real Property 
Taxes by appropriate proceedings, provided that Tenant gives Landlord prior 
Notice of any such contest and keeps Landlord advised as to all proceedings, 
and provided further that Tenant shall continue to reimburse Landlord for 
Landlord's payment of such Real Property Taxes unless such proceedings shall 
operate to prevent or stay such payment and the collection of the tax so 
contested.  Landlord shall join in any such proceedings if any Applicable 
Laws shall so require, provided that Tenant shall hold harmless, indemnify, 
protect and defend Landlord from and against any liability, claim, demand, 
cost or expense in connection therewith including, but not limited to, 
actual attorneys' fees and costs reasonably incurred.

     7.7     Utilities and Services.  Tenant shall be responsible for and 
shall pay promptly, directly to the appropriate supplier, all charges for 
water, gas, electricity, heat, light, power, telephone, refuse pickup, 
janitorial service, interior landscape maintenance and all other utilities, 
materials and services furnished directly to Tenant or the Premises or used 
by Tenant in, on or about the Premises during the Term, together with any 
taxes thereon.  If any utilities or services are not separately metered or 
assessed to Tenant, Landlord shall make a reasonable determination of 
Tenant's proportionate share of the cost of such utilities and services and 
Tenant shall pay such amount to Landlord, as an item of Additional Rent, 
within thirty (30) days after receipt of Landlord's statement or invoice 
therefor.  Alternatively, Landlord may elect to include such cost in the 
definition of Project Costs, in which event Tenant shall pay Tenant's share 
of such cost in the manner set forth in Section 7.1.  Landlord may also 
require Tenant to have any Specialized HVAC system separately metered to 
Tenant, at Tenant's expense.  Landlord shall not be liable in damages or 
otherwise for any failure or interruption of any utility or other service 
furnished to the Premises, unless the direct result of or directly caused by 
Landlord's gross negligence.  No such failure or interruption shall be 
deemed an eviction or entitle Tenant to terminate this Lease or withhold or 
abate any Rent due hereunder.


                                ARTICLE VIII

                                ALTERATIONS

     8.1     Permitted Alterations.  After the Commencement Date, Tenant 
shall not make or permit any Alterations in, or about the Premises without 
the prior written consent of Landlord (which consent shall not be 
unreasonably withheld), except for the Work defined in the Workletter 
attached hereto as Exhibit "C", and Alterations not exceeding Five Thousand 
Dollars ($5,000.00) per occurrence.  Notwithstanding the foregoing, without 
the prior written consent of Landlord (which consent shall not be 
unreasonably withheld, in no event shall any Alterations (i)affect the 
exterior of the Building or the outside areas (or be visible from adjoining 
sites), (ii)affect or penetrate any of the structural portions of the 
Building including, but not limited to, the roof, (iii)require any change to 
the basic floor plan of the Premises, any change to the structural or 
mechanical components of the Premises, or any governmental approval or 
permit as a prerequisite to the construction thereof, (iv) interfere in any 
manner with the proper functioning of or Landlord's access to any 
mechanical, electrical, plumbing or HVAC systems, facilities or equipment 
located in or serving the Building, or (v)diminish the value of the 
Premises.  All Alterations shall be constructed pursuant to plans and 
specifications previously provided to and, when applicable, approved in 
writing by Landlord, shall be installed by a licensed contractor at Tenant's 
sole expense in compliance with all Applicable Laws, and shall be 
accomplished in a good and workmanlike manner conforming in quality and 
design with the Premises existing as of the Commencement Date.  No Hazardous 
Materials including, but not limited to, asbestos or asbestos-containing 
materials, shall be used by Tenant or Tenant's Agents in the construction of 
any Alterations permitted hereunder. All Alterations made by Tenant shall be 
and become the property of Landlord upon the installation thereof and shall 
not be deemed Tenant's Personal Property; provided, however, that except for 
the Work defined in the Workletter attached hereto as Exhibit "C", Landlord 
may, at its option, require that Tenant, upon the termination of this Lease, 
at Tenant's expense, remove any or all nonstructural Alterations, except 
Alterations required by law, installed by or on behalf of Tenant and return 
the Premises to its condition as of the Commencement Date of this Lease, 
normal wear and tear excepted.  Notwithstanding any other provisions of this 
Lease, Tenant shall be solely responsible for the maintenance, repair and 

                                  -12-
<PAGE>

replacement of any and all Alterations made by or on behalf of Tenant 
(including without limitation by Landlord on behalf of Tenant) to the 
Premises.

     8.2     Trade Fixtures.  Tenant shall, at its own expense, provide, 
install and maintain in good condition all of Tenant's Personal Property 
required in the conduct of its business in the Premises.

     8.3     Mechanic's Liens.  Tenant shall give  Landlord Notice of 
Tenant's intention to perform any work on the Premises which might result in 
any claim of lien at least twenty (20) days prior to the commencement of 
such work to enable Landlord to post and record a notice of 
nonresponsibility or other notice Landlord deems proper prior to the 
commencement of any such work.  Tenant shall not permit any mechanic's, 
materialmen's or other liens to be filed against the property of which the 
Premises are a part or against Tenant's leasehold interest in the Premises.  
If Tenant fails to cause the release of record of any lien(s) filed against 
the Premises or its leasehold estate therein by payment or posting of a 
proper bond within ten (10) days from the date of the lien filing(s), then 
Landlord may, at Tenant's expense, cause such lien(s) to be released by any 
means Landlord deems proper including, but not limited to, payment of or 
defense against the claim giving rise to the lien(s).  All sums reasonably 
disbursed, deposited or incurred by Landlord in connection with the release 
of the lien(s) including, but not limited to, all costs, expenses and actual 
attorneys' fees, shall be due and payable by Tenant to Landlord, as an item 
of Additional Rent, on demand by Landlord, together with interest thereon at 
the Applicable Rate from the date of such demand until paid by Tenant.


                                   ARTICLE IX

                            MAINTENANCE AND REPAIR

     9.1  Landlord's Maintenance of Outside Areas. Landlord shall, 
subject to receiving Tenant's payment of Maintenance Expenses, and subject 
to Section 9.2, Article XII and Article XIII, maintain in good condition and 
repair the Outside Areas and every part thereof, including but not limited 
to, landscaping (including replacement thereof), sprinkler systems, 
walkways, parking areas, and approved signage. Such maintenance shall 
include pest control, restriping of the parking areas and painting of the 
exterior walls of the Building, as and when the same becomes necessary in 
Landlord's sole discretion which shall not be unreasonable, maintenance and 
repair of the foundations, exterior walls and the structural condition of 
interior bearing walls.  The cost of any maintenance and repairs on the part 
of Landlord provided for in this Section 9.1 shall be amortized over the 
longest useful life permitted under the Internal Revenue Code and shall be 
considered part of Maintenance Expenses and paid by Tenant in the manner set 
forth in Section 7.1, except that repairs which Landlord deems arise out of 
any act or omission of Tenant or Tenant's Agents shall be made at the 
expense of Tenant. Landlord's obligation to repair and maintain hereunder 
shall be limited to the cost of effecting such repair and maintenance and in 
no event shall Landlord be liable for any costs or expenses in excess of 
said amounts, including but not limited to any consequential damages, 
opportunity costs or lost profits incurred or suffered by Tenant.  Landlord 
shall be responsible at Landlord's sole cost and expense to repair any 
damage to the Premises caused by Landlord's or Landlord's Agents' 
negligence, willful acts or omissions or default.

     9.2.  Tenant's Maintenance and Repair Obligations.  Except as 
otherwise provided, Tenant shall at all times during the Term of this Lease, 
at Tenant's sole cost and expense, clean, keep, maintain, repair and make 
necessary improvements to, the Building and every part thereof and all 
improvements therein or thereto, in good and sanitary order and condition to 
the reasonable satisfaction of Landlord and in compliance with all 
Applicable Laws.  Tenant's repair and maintenance obligations herein shall 
include, but are not limited to, all necessary maintenance and repairs to 
all portions of the Building, and all exterior entrances, all glass, 
windows, window casements, show window moldings, partitions, doors, 
doorjambs, door closures, hardware, fixtures, electrical lighting and 
outlets, plumbing fixtures, sewage facilities, interior walls, floors, 
ceilings, skylights, fans and exhaust equipment, fire extinguisher equipment 
and systems, the roof of the Building, all HVAC equipment, and all repairs 
to Specialized HVAC (as hereinafter defined). As part of its maintenance 
obligations hereunder, Tenant shall, at Landlord's request, provide Landlord 
with copies of all maintenance schedules regarding the maintenance of the 
Building, reports and notices prepared by, for, or on behalf of Tenant. 
Landlord may impose reasonable restrictions and requirements with respect to 
repairs by Tenant, which repairs shall be at least equal in quality to the 
original work, and the provisions of Section 8.3 shall apply to all such 
repairs. Tenant's obligation to repair includes the obligation to replace, 

                                  -13-
<PAGE>

as necessary, regardless of whether the benefit of such replacement extends 
beyond the Term, subject, however, to the following: So long as:

     1.     Tenant is not in default;

     2.     Tenant submits reasonably satisfactory evidence of payment and 
maintenance, including without limitation copies of all 
invoices, receipts, maintenance records and the like; and 
     
     3.     All systems, equipment and other items or things provided herein 
or contemplated hereby are in good condition, working order and 
otherwise in compliance with the terms of this Lease;

as soon as reasonably possible after the expiration of the Lease Term, 
Landlord shall (partially) reimburse Tenant for the reasonable cost of a 
replacement item pro rata based upon Landlord's reasonable determination of 
that portion of the useful life of such item which will extend beyond the 
Term, provided that, prior to making any expenditure for such replacement 
item:

     A.     Tenant notifies Landlord in writing of Tenant's desire to 
replace the item;

     B.     Tenant provides to Landlord adequate information concerning the 
reasonable cost, anticipated useful life, type of item to be 
used as a replacement (name, model number, etc.) and such other 
information as Landlord shall reasonably request; and
     
     C.     Landlord consents to reimburse a portion of the cost of such 
replacement item as provided herein.

Such consent pursuant to provision C shall not to be unreasonably withheld 
or delayed, but shall only be required to be given after Landlord receives 
from Tenant the written notice and other information contemplated by 
provisions A and B above, which must actually be received by Landlord at 
least five (5) business days prior to Tenant's proposed purchase of the 
replacement item.  Notwithstanding the fact that Landlord shall make its 
determination as to whether or not a replacement item is eligible for 
(partial) reimbursement pursuant to the foregoing provisions within five(5) 
business days after actual receipt of the written notice and other 
information contemplated by provisions A and B above, Landlord need not make 
a determination as to or pay the actual amount of such (partial) 
reimbursement until the expiration of the Term, Tenant's qualification for 
the (partial) reimbursement pursuant to provisions 1,2 and 3 above and after 
Landlord's inspection of the then current condition of the relevant 
replacement item to be conducted immediately after the end of said Term, 
Landlord's reasonable determination of the remaining useful life of the 
replacement item.
Any special or above-standard heating, ventilating and air conditioning 
installed by, on behalf of, or at the request of Tenant ("Specialized 
HVAC"), shall be paid for and maintained by Tenant at Tenant's sole cost and 
expense. Notwithstanding the foregoing, Landlord shall have the right, upon 
Notice to Tenant, to undertake the responsibility for maintenance and repair 
of automatic fire extinguisher equipment, such as sprinkler systems and 
alarms, Specialized HVAC and other obligations of Tenant hereunder which 
Landlord deems appropriate to undertake, in which event the cost thereof 
shall be included as part of Maintenance Expenses and paid by Tenant in the 
manner set forth in Section 7.1.

     9.3     Waiver.  Tenant hereby waives all rights provided for by the 
provisions of Sections 1941 and 1942 of the California Civil Code and any 
present or future laws regarding Tenant's right to make repairs at the 
expense of Landlord or to terminate this Lease because of the condition of 
the Premises.

     9.4     Self-Help.  If Tenant refuses or fails to repair and maintain 
the Premises as required hereunder within ten (10) days from the date on 
which Landlord makes a written demand on Tenant to effect such repair and 
maintenance, Landlord may enter upon the Premises and make such repairs or 
perform such maintenance without liability to Tenant for any loss or damage 
that may accrue to Tenant or its merchandise, fixtures or other property or 
to Tenant's business by reason thereof, unless due to the negligence or 
willful misconduct of Landlord.  All sums reasonably disbursed, deposited or 
incurred by Landlord in connection with such repairs or maintenance, plus 
percent (5%) for overhead, shall be due and payable by Tenant to Landlord, 
as an item of Additional Rent, on demand by Landlord, together with interest 
at the Applicable Rate on such aggregate amount from the date of such demand 
until paid by Tenant.

                                  -14-
<PAGE>



                                  ARTICLE X

                          COMMON AREA AND PARKING

In the event that the Building becomes multi-tenanted, the following shall 
apply.

     10.1     Grant of Nonexclusive Common Area License and Right.  
Landlord hereby grants to Tenant and its permitted subtenants, in common 
with Landlord and all persons, firms and corporations conducting business in 
the Project and their respective customers, guests, licenses, invitees, 
subtenants, employees and agents, the nonexclusive license and right to use 
the Common Area within the Project for vehicular parking, for pedestrian and 
vehicular ingress, egress and travel, and for such other purposes and for 
doing such other things as may be provided for, authorized and/or permitted 
by the Restrictions, such nonexclusive license and right to be appurtenant 
to Tenant's leasehold estate created by this Lease.  The nonexclusive 
license and rights granted pursuant to the provisions of this Article X shall 
be subject to the provisions of the Restrictions, which pertaining any way 
to the Common Area covered by such Restrictions, and the provisions of this 
Lease.

     10.2     Use of Common Area.  Notwithstanding anything to the contrary 
herein, Tenant and its successors, assigns, employees, agents and invitees 
shall use the Common Area only for the purposes permitted hereby and by the 
Restrictions and the Rules and Regulations.  All uses permitted within the 
Common Area shall be undertaken with reason and judgment so as not to 
interfere with the primary use of the Common Area which is to provide 
parking and vehicular and pedestrian access throughout the Common Area 
within the Project and to adjacent public streets for the Landlord, 
Landlord's Agents, its tenants, subtenants and all persons, firms and 
corporations conducting business within the Project and their respective 
customers, guests and licensees.  In no event shall Tenant erect, install, 
or place, or cause to be erected, installed, or placed any structure, 
building, trailer, fence, wall, signs or other obstructions on the Common 
Area except as otherwise permitted herein and in the Restrictions, and 
Tenant shall not store or sell any merchandise, equipment or materials on 
the Common Area.

     10.3     Control of Common Area.  Subject to provisions of the 
Restrictions, all Common Area and all improvements located from time to time 
within the Common Area shall at all times be subject to the exclusive 
control and management of the Landlord.  Landlord shall have the right to 
construct, maintain and operate lighting facilities within the Common Area; 
to police the Common Area from time to time; to change the area, level, 
location and arrangement of the parking areas and other improvements within 
the Common Area; to restrict parking by tenants, their officers, agents and 
employees to employee parking areas; to enforce parking charges (by 
operation of meters or otherwise); to close all or any portion of the Common 
Area or improvements therein to such extent as may, in the opinion of 
counsel for Landlord, be legally sufficient to prevent a dedication thereof 
or the accrual of any rights to any person or to the public therein; to 
close temporarily all or any portion of the Common Area and/or the 
improvements thereon; to discourage noncustomer parking; and to do and 
perform such other acts in and to said Common Area and improvements thereon 
as, in the use of good business judgment, Landlord shall determine to be 
advisable.

     10.4     Maintenance of Common Area.  Landlord shall operate and 
maintain (or cause to be operated and maintained) the Common Area in a 
first-class condition, in such manner as Landlord in its sole discretion 
shall determine from time to time.  Without limiting the scope of such 
discretion, Landlord shall have the full right and authority to employee or 
cause to be employed all personnel and to make or cause to be made all rules 
and regulations pertaining to or necessary for the proper operation and 
maintenance of the Common Area and the improvements located thereon.  The 
cost of such maintenance of the Common Area shall be included as part of 
Project Costs.  No part of the Common Area may be used for the storage of 
any items, including without limitation, vehicles, materials, inventory and 
equipment.  All trash and other refuse shall be placed in designated 
receptacles.  No work of any kind including, but not limited to, painting, 
drying, cleaning, repairing, manufacturing, assembling, cutting, 
merchandising or displaying shall be permitted upon the Common Area.

     10.5     Revocation of License.  All Common Area and improvements 
located thereon which Tenant is permitted to use and occupy pursuant to the 
provisions of this Lease are to be used and occupied under a revocable 
license and right, and if any such license be revoked, or if the amount of 
such areas be diminished, Landlord shall not be subject to any liability nor 
shall Tenant be entitled to compensation or diminution or abatement of Rent, 
and such revocation or diminution of such areas shall not be deemed 
constructive or actual eviction.  It is understood and agreed that the 
condemnation or other taking or appropriation by any public or quasi-public 

                                  -15-
<PAGE>

authority, or sale in lieu of condemnation, of all or any portion of the 
Common Area shall not constitute a violation of Landlord's agreements 
hereunder, and Tenant shall not be entitled to participate in or make any 
claim for any award or other condemnation proceeds arising from any such 
taking or appropriation of the Common Area.  Notwithstanding the foregoing, 
so long as no Event of Default has occurred and is continuing, Landlord 
shall provide to Tenant the number of vehicle parking spaces set forth in 
Item 15 of the Basic Lease Provisions throughout the Term (subject to the 
rights of Landlord under this Article X).

     10.6     Landlord's Reserved Rights.  Landlord reserves the right to 
install, use, maintain, repair, relocate and replace pipes, ducts, conduits, 
wires and appurtenant meters and equipment included in the Premises or 
outside the Premises, change the boundary lines of the Project and install, 
use, maintain, repair, alter or relocate, expand and replace any Common 
Area; provided, however, Landlord shall not unreasonably interfere with 
Tenant's use of the Premises.  Such rights of Landlord shall include, but 
are not limited to, designating from time to time certain portions of the 
Common Area as exclusively for the benefit of certain tenants in the 
Project.

     10.7     Parking.  Tenant shall be entitled to the number of vehicle 
parking spaces set forth in Item 15 of the Basic Lease Provisions, which 
spaces shall be unreserved and unassigned, on those portions of the Common 
Area designated by Landlord for parking.  Tenant shall not use more parking 
spaces than such number.  All parking spaces shall be used only for parking 
by vehicles no larger than full-size passenger automobiles pick-up trucks or 
delivery trucks.  Tenant shall not permit or allow any vehicles that belong 
to or are controlled by Tenant or Tenant's employees, suppliers, shippers, 
customers, or invitees to be loaded, unloaded, or parked in areas other than 
those designated by Landlord for such activities.  If Tenant permits or 
allows any of the prohibited activities described above, then Landlord shall 
have the right, without notice, in addition to such other rights and 
remedies that Landlord may have, to remove or tow away the vehicle involved 
and charge the cost to Tenant, which cost shall be immediately payable upon 
demand by Landlord.  Parking within the Common Area shall be limited to 
striped parking stalls, and no parking shall be permitted in any driveways, 
accessways or in any area which would prohibit or impede the free flow of 
traffic within the Common Area. If Tenant parks vehicles overnight at the 
Project, Tenant shall indemnify, defend and hold Landlord free and harmless 
of, from and against any and all claims, demands, suits, damages, losses, 
liabilities, costs, and/or expenses (including reasonable attorneys' fees) 
arising out of, resulting from or incurred in connection with the overnight 
parking of vehicles at the project. Vehicles which have been abandoned or 
parking in violation of the terms hereof may be towed away at the owner's 
expense.

                               ARTICLE XI
                        INDEMNITY AND INSURANCE

     11.1     Indemnification.  To the fullest extent permitted by law, 
Tenant hereby agrees to defend (with attorneys reasonably acceptable to 
Landlord), indemnify, protect and hold harmless Landlord and Landlord's 
Agents and any successors to all or any portion of Landlord's interest in 
the Premises and their directors, officers, partners, employees, authorized 
agents, representatives, affiliates and Mortgagees, from and against any and 
all damage, loss, claim, liability and expense including, but not limited 
to, actual attorneys' fees and legal costs, incurred directly or indirectly 
by reason of any claim, suit or judgment brought by or on behalf of (i) any 
person or persons for damage, loss or expense due to, but not limited to, 
bodily injury or property damage sustained by such person or persons which 
arise out of, are occasioned by, or are in any way attributable to the use 
or occupancy of the Premises or the acts or omissions of the Tenant or 
Tenant's Agents in or about the Premises or the Project (including, but not 
limited to, any Event of Default hereunder), or (ii) Tenant or Tenant's 
Agents for damage, loss or expense due to, but not limited to, bodily injury 
or property damage which arise out of, are occasioned by, or are in any way 
attributable to the use of any of the Common Area, except to the extent 
caused by the sole active negligence or willful misconduct of Landlord.

     11.2.  Property Insurance. Landlord shall obtain and keep in force 
during the Term, (i) an "all risk" or "special causes of action" property 
policy, including earthquake and flood, in the amount of the full 
replacement cost covering the Premises, the Building and objects owned by 
Landlord and normally covered under a "Boiler and Machinery" policy and any 
Alterations made by or at the request of Tenant, and (ii) an "all risk" or 
"special causes of action" policy of business interruption and/or loss of 
income insurance covering a period of one (1) year, with loss payable to 
Landlord to the extent of Monthly Rent and Additional Rent only. Tenant 
shall within ten (10) days of receipt of Landlord's invoice or statement for 
such insurance pay or reimburse Landlord the cost of same such insurance in 
an amount not to exceed Six Thousand Dollars ($6,000.00) per year. Tenant 
shall maintain and keep in force at its sole cost and expense insurance 
covering its Personal Property.  


                                  -16-
<PAGE>

     11.3     Liability/Miscellaneous Insurance.  Tenant shall maintain 
in full force and effect at all times during the Term (plus such earlier and 
later periods as Tenant may be in occupancy of the Premises), at its sole 
cost and expense, for the protection of Tenant, Landlord and Landlord's 
Agents and Mortgagees, policies of insurance issued by a carrier or carriers 
in accordance with Section 11.8 which afford the following coverages:  (i) 
statutory workers' compensation, (ii) employer's liability with minimum 
limits of Five Hundred Thousand Dollars ($500,000), and (iii) 
comprehensive/commercial general liability including, but not limited to, 
blanket contractual liability (including the indemnity set forth in Section 
11.1), fire and water legal liability, broad form property damage, personal 
injury, completed operations, products liability, independent contractors, 
and, if alcoholic beverages are served, or sold in the Premises, 
comprehensive Host Liquor Liability Insurance, and owned, non-owned and 
hired vehicles, of not less than the limits set forth in Item 17 of the Basic 
Lease Provisions (or current limit carried, whichever is greater), naming 
Landlord, the Mortgagees, and the Additional Insureds named in Item 16 of the 
Basic Lease Provisions as additional insureds, and including a cross-
liability or severability interests indorsement.

     11.4     Hazardous Materials.  In the event Landlord consents to 
Tenant's use, generation or storage of Hazardous Materials on, under or 
about the Premises pursuant to Section 6.2, and if at any time Tenant's net 
worth is less than Twenty-Five Million Dollars (25,000,000.00), Landlord 
shall have the right to require Tenant, at Tenant's sole cost and expense, 
to purchase insurance specified and approved by Landlord, with coverage of 
no less than Five Million Dollars ($5,000,000), insuring (i) any Hazardous 
Materials shall be removed from the Premises, (ii) the Premises shall be 
restored to a clean, neat, attractive, healthy, safe and sanitary condition, 
and (iii) any liability of Tenant, Landlord and Landlord's Agents arising 
from such Hazardous Materials.

     11.5     Deductibles; Blanket Coverage.  Any policy of Property 
Insurance required pursuant to this Lease containing a deductible exceeding 
Five Thousand Dollars ($5,000) per occurrence must be approved in writing by 
Landlord prior to the issuance of such policy, which approval shall not be 
unreasonably withheld.  Tenant shall be solely responsible for the payment 
of any deductible.  Any Property Insurance required of Tenant pursuant to 
this Lease may be provided by means of a so-called "blanket policy", so long 
as (i) the Premises are specifically covered (by rider, endorsement or 
otherwise), (ii) the limits of the policy are applicable on a "per location" 
basis to the Premises and provide for restoration of the aggregate limits, 
and (iii) the policy otherwise complies with the provisions of this Lease.

     11.6     Increased Coverage.  In the event that Tenant exercises its 
Option to Extend as defined in the Rider No. 1 to Lease attached hereto, 
Tenant shall provide Landlord, at Tenant's expense, with such increased 
amount of existing insurance, and such other insurance as Landlord or the 
Mortgagees may reasonably require, in coverages and amounts comparable to 
similar users and buildings in the general area.

     11.7     Sufficiency of Coverage. Neither Landlord nor any of 
Landlord's Agents makes any representation that the types of insurance and 
limits specified to be carried by Tenant under this Lease are adequate to 
protect Tenant.  If Tenant believes that any such insurance coverage is 
insufficient, Tenant shall provide, at its own expense, such additional 
insurance as Tenant deems adequate.  Nothing contained herein shall limit 
Tenant's liability under this Lease, and Tenant's liability under any 
provision of this Lease, including without limitation under any indemnity 
provisions, shall not be limited to the amount of any insurance obtained.

     11.8     Insurance Requirements. Tenant's insurance (i) shall be in 
accordance with the above requirements and shall be carried with companies 
that have a Best's policyholder's rating of not less than "A", (ii) shall 
provide that such policies shall not be subject to cancellation except after 
at least thirty (30) days prior written notice to Landlord, and (iii) shall 
be primary, and any insurance carried by Landlord or Landlord's Agents shall 
be noncontributing.  Tenant's policy or policies, or duly executed 
certificates for them shall be deposited with Landlord prior to the 
Commencement Date. Prior to renewal of such policies a binder evidencing 
continued coverage shall be deposited with Landlord, which binder shall be 
replaced by a certificate of insurance within sixty (60) days.  If Tenant 
fails to procure and maintain the insurance required to be procured by 
Tenant under this Lease, Landlord may, but shall not be required to, order 
such insurance at Tenant's expense.  All sums reasonably disbursed, 
deposited or incurred by Landlord in connection therewith including, but not 
limited to, all costs, expenses and actual attorneys' fees, shall be due and 
payable by Tenant to Landlord, as an item of Additional Rent, on demand by 
Landlord, together with interest thereon at the Applicable Rate from the 
date of such demand until paid by Tenant. Notwithstanding the foregoing, if 

                                  -17-
<PAGE>

Landlord orders such insurance on Tenant's behalf, and Tenant did in fact 
maintain such insurance without interruption as required in this Section 
11.8, then Landlord shall bear the cost of the insurance that Landlord 
ordered on Tenant's behalf.

     11.10  Landlord's Disclaimer.  Notwithstanding any other provisions 
of this Lease, and to the fullest extent permitted by law, Landlord and 
Landlord's Agents shall not be liable for any loss or damage to persons or 
property resulting from theft, vandalism, fire, explosion, falling 
materials, glass, tile or sheetrock, steam, gas, electricity, water or rain 
which may leak from any part of the Premises, or from the pipes, appliances 
or plumbing works therein or from the roof, street or subsurface or 
whatsoever, unless caused by or due to the sole active negligence or willful 
misconduct of Landlord. Tenant shall give prompt Notice to Landlord in case 
of a casualty, accident or repair needed to the Premises.

     11.10  Waiver of Subrogation. Landlord and Tenant each hereby waive 
all rights of recovery against the other and against the officers, 
employees, agents and representatives of the other, on account of loss by or 
damage to any person or the waiving party's property or the property of 
others under its control, to the extent that such loss or damage is insured 
against under any fire and extended coverage insurance policy which either 
may have or is required to have in force at the time of the loss or damage.  
Landlord and Tenant shall each obtain from their respective insurers under 
all policies of fire, theft, public liability, worker's compensation, and 
other insurance maintained during the Term of this Lease covering the 
Building, or any portion of it, or operations in it, a waiver of all rights 
of subrogation that the insurer of one party might have against the other 
party.  Landlord and Tenant shall each indemnify the other against any loss 
or expense, including reasonable attorney's fees, resulting from the failure 
to obtain this waiver.


                                 ARTICLE XII

                           DAMAGE OR DESTRUCTION

     12.1     Landlord's Obligation to Rebuild.  If the Premises are 
damaged or destroyed by fire or other casualty (a "Casualty"), Tenant shall 
promptly give notice thereof to Landlord, and Landlord shall thereafter 
repair the Premises as set forth in Sections 12.4 and 12.5 unless Landlord 
has the right to terminate this Lease as provided in Section 12.2 and 
Landlord elects to so terminate or Tenant has the right to terminate this 
Lease as provided in Section 12.3 and Tenant elects to so terminate.

     12.2     Landlord's Right to Terminate.  Landlord shall have the 
right to terminate this Lease following a Casualty if any of the following 
occurs:  (i) insurance proceeds (together with any additional amounts Tenant 
elects, at is option, to contribute) are not available to Landlord to pay 
one hundred percent (100%) of the cost to fully repair the Premises, 
excluding the deductible (for which Tenant shall pay Tenant's share of such 
deductible; (ii) Landlord's Architect determines that the Premises cannot, 
with reasonable diligence, be fully repaired by Landlord (or cannot be 
safely repaired because of the presence of hazardous factors including, but 
not limited to, Hazardous Materials, earthquake faults, radiation, chemical 
waste and other similar dangers) within one hundred eighty (180) days after 
the date of such Casualty; (iii) the Premises are destroyed or damaged during 
the last twelve (12) months of the Term; or (iv) an Event of Default has 
occurred and is continuing at the time of such Casualty and continues 
unabated for thirty (30) days thereafter.  If Landlord elects to terminate 
this Lease following a Casualty pursuant to this Section 12.2, Landlord shall 
give Tenant Notice of its election to terminate within thirty (30) days 
after Landlord has knowledge of such Casualty, and this Lease shall 
terminate fifteen (15) days after the date of such Notice.

     12.3     Tenant's Right to Terminate.  Subject to the latter terms 
hereof, Tenant shall have the right to terminate this Lease following the 
destruction of the Premises (or damage to the Premises so extensive as to 
reasonably prevent Tenant's substantial use and enjoyment of the Premises) 
if any of the following occurs:  (i) the Premises cannot, with reasonable 
diligence, be fully repaired by Landlord within two hundred (200) days after 
the date of the damage or destruction, as determined by Landlord's 
Architect; (ii) the Premises cannot safely be repaired because of the 
presence of hazardous factors, including Hazardous Materials, earthquake 
faults, radiation, chemical waste and other similar dangers; or (iii) the 
damage or destruction occurs during the last twelve (12) months of the Term 
and cannot, with reasonable diligence, be fully repaired by Landlord within 
ninety (90) days after the date of the destruction or damage, as determined 
by Landlord's Architect.  Notwithstanding the foregoing, Tenant shall not 
have the right to terminate under this Section 12.3 if (a) an Event of 
default 

                                  -18-
<PAGE>

has occurred and is continuing at the time of such damage or destruction or 
at the time of exercising the right to terminate, or (b) the damage or 
destruction was caused, in whole or in part, by the act or omission of 
Tenant's or Tenant's Agents.  If Tenant elects to terminate this Lease 
pursuant to this Section 12.3, Tenant shall give Landlord Notice of its 
election to terminate within thirty (30) days after the date of such damage 
or destruction, and this Lease shall terminate fifteen (15) days after the 
date of such Notice.

     12.4     Effect of Termination.  If this Lease is terminated following 
a Casualty pursuant to Section 12.2 or Section 12.3, Landlord shall, subject 
to the rights of the Mortgagees, be entitled to receive and retain all the 
insurance proceeds resulting from or attributable to such Casualty, except 
for those proceeds payable under policies obtained by Tenant which 
specifically insure Tenant's Personal Property.  If neither party exercises 
any such right to terminate this Lease, this Lease will continue in full 
force and effect, and Landlord shall, promptly following the tenth (10th) 
day after the date of such Casualty and receipt of the amounts set forth in 
clause (i) of Section 12.2, commence the process of obtaining necessary 
permits and approvals for the repair of the Premises, and shall commence 
such repair and prosecute the same diligently to completion as soon 
thereafter as is practicable.  Tenant shall fully cooperate with Landlord in 
removing Tenant's Personal Property and any debris from the Premises to 
facilitate the making of such repairs.

     12.5     Limited Obligation to Repair.  Landlord's obligation, 
should it elect or be obligated to repair the Premises following a Casualty, 
shall be limited to the basic Building and Tenant Improvements and Tenant 
shall, at its expense, replace or fully repair all Tenant's Personal 
Property and any Alterations installed by Tenant existing at the time of 
such Casualty.  If the Premises are to be repaired in accordance with the 
foregoing, Tenant shall make available to Landlord any portion of insurance 
proceeds it receives which are allocable to the Tenant Improvements.

     12.6     Abatement of Monthly Rent.  During any period when a 
mutually agreed upon third party architect reasonably determines that there 
is substantial interference with Tenant's use of the Premises by reason of a 
Casualty, Monthly Rent shall be temporarily abated in proportion to the 
degree of such substantial interference, but only to the extent of any 
business interruption or loss of income insurance proceeds received by 
Landlord from Tenant's insurance described in Section 11.2.  Such abatement 
shall commence upon the date Tenant notifies Landlord of such Casualty and 
shall end upon the Substantial Completion of the repair of the Premises 
which Landlord undertakes or is obligated to undertake hereunder.  Tenant 
shall not be entitled to any compensation or damages from Landlord for loss 
of the use of the Premises, Tenant's Personal Property or other damage or 
any inconvenience occasioned by a Casualty or by the repair or restoration 
of the Premises thereafter, including, but not limited to, any consequential 
damages, opportunity costs or lost profits incurred or suffered by Tenant.  
Tenant hereby waives the provisions of Section 1932(2) and Section 1933(4) of 
the California Civil Code, and the provisions of any similar or successor 
statues.

     12.7     Landlord's Determination.  The determination  in good faith 
by a mutually agreed upon third party architect of or relating to the 
estimated cost of repair of any damage, replacement cost, the time period 
required for repair or the interference with or suitability of the Premises 
for Tenant's use or occupancy shall be conclusive for purposes of this 
Article XII and Article XIII.


                                ARTICLE XIII

                                CONDEMNATION

     13.1     Total Taking--Termination.  If title to the Premises or so 
much thereof is taken for any public or quasi-public use under any statute 
or by right of eminent domain so that reconstruction of the Premises will 
not result in the Premises being reasonably suitable for Tenant's continued 
occupancy for the uses and purposes permitted by this Lease, this Lease 
shall terminate as of the date possession of the Premises or part thereof is 
so taken.

     13.2     Partial Taking.  If any part of the Premises is taken for any 
public or quasi-public use under any statute or by right of eminent domain 
and the remaining part is reasonably suitable for Tenant's continued 
occupancy for the uses permitted by this Lease, this Lease shall, as to the 
part so taken, terminate as of the date that possession of such part of the 
Premises is taken and the Monthly Rent shall be reduced in the same 
proportion than the floor area of the portion of the Premises so taken (less 
any addition thereto by reason of any reconstruction) bears to the original 
floor area of the Premises, as reasonably determined by Landlord or 
Landlord's Architect.  Landlord shall, at its own cost and expense, make all 

                                  -19-
<PAGE>

necessary repairs or alterations to the Premises so as to make the portion 
of the Premises not taken a complete architectural unit.  Such work shall 
not, however, exceed the scope of the work done by Landlord in originally 
constructing the Premises.  If severance damages from the condemning 
authority are not available to Landlord in sufficient amounts to permit such 
restoration, Landlord may terminate this Lease upon Notice to Tenant.  
Monthly Rent due and payable hereunder shall be temporarily abated during 
such restoration period in proportion to the degree to which there is 
substantial interference with Tenant's use of the Premises, as reasonably 
determined by Landlord or Landlord's Architect.  Each party hereby waives 
the provisions of Section 1265.130 of the California Code of Civil Procedure 
and any present or future law allowing either party to petition the Superior 
Court to terminate this Lease in the event of a partial taking of the 
Building or Premises.

     13.3     No Apportionment of Award.  Any award for any partial or 
total taking shall be apportioned between the respective interests of 
Landlord and Tenant in accordance with California law.

     13.4     Temporary Taking.  No temporary taking of the Premises (which 
for purposes hereof shall mean a taking of all or any part of the Premises 
for one hundred eighty (180) days or less) shall terminate this Lease or 
give Tenant any right to any abatement of Rent.  Any award made to Tenant by 
reason for such temporary taking shall belong entirely to Tenant and 
Landlord shall not be entitled to share therein.  Each party agrees to 
execute and deliver to the other all instruments that may be required to 
effectuate the provisions of this Section 13.4.

     13.5     Sale Under Threat of Condemnation.  A sale made in good 
faith to any authority having the power of eminent domain, either under 
threat of condemnation or while condemnation proceedings are pending, shall 
be deemed a taking under the power of eminent domain for all purposes of 
this Article XIII.


                                 ARTICLE XIV

                         ASSIGNMENT AND SUBLETTING

     14.1     Prohibition.  Tenant shall not directly or indirectly, 
voluntarily or by operation of law, assign (which term shall include any 
transfer, assignment, pledge, mortgage or hypothecation) this Lease, or any 
right or interest hereunder, or sublet the Premises or any part thereof, or 
allow any other person or entity to occupy or use all or any part of the 
Premises without first obtaining the written consent of Landlord in each 
instance, which consent shall not be unreasonably withheld.  No assignment, 
encumbrance, subletting, or other transfer in violation of the terms of this 
Article XIV, whether voluntary or involuntary, by operation of law, under 
legal process or proceedings, by receivership, in bankruptcy, or otherwise 
shall be valid or effective and, at the option of Landlord, shall constitute 
an Event of Default under this Lease.  To the extent not prohibited by 
provisions of the Bankruptcy Code of 1978, 11 U.S.C. Section 101 et seq. (the 
"Bankruptcy Code"), Tenant on behalf of itself, creditors, administrators 
and assigns waives the applicability of Sections 541(c) and 365(e) of the 
Bankruptcy Code unless the proposed assignee of the trustee for the estate 
of the bankrupt meets Landlord's standards for consent as set forth role.  
Landlord has entered into this Lease with Tenant in order to obtain for the 
benefit of the project the unique attraction of Tenant's name and business; 
the foregoing prohibition on assignment or subletting is expressly agreed to 
by Tenant in consideration of such fact.  If this Lease is assigned to any 
person or entity pursuant to the provisions of the Bankruptcy Code, any and 
all monies or other considerations payable or otherwise to be delivered in 
connection with such assignment shall be paid or delivered to Landlord, 
shall be and remain the exclusive property of Landlord and shall not 
constitute property of Tenant or the estate of Tenant within the meaning of 
the Bankruptcy Code.  Any and all monies or other considerations 
constituting Landlord's property under the proceeding sentence not paid or 
delivered to Landlord shall be held in trust for the benefit of Landlord and 
be promptly paid or delivered to Landlord.  Any person or entity to which 
this Lease is assigned pursuant to the provisions of the Bankruptcy Code 
shall be deemed without further act or deed to have assumed all of the 
obligations arising under this Lease on and after the date of such 
assignment.  Any such assignee shall upon demand execute and earlier to 
Landlord an instrument confirming such assumption.

     14.2     Landlord's Consent.  In the event Landlord consents to any 
assignment or subletting, such consent shall not constitute a waiver of any 
of the restrictions of this Article XIV and the same shall apply to each 
successive assignment or subletting hereunder, if any.  In no event shall 
Landlord's consent to an assignment or subletting affect the continuing 

                                  -20-
<PAGE>

primary liability of Tenant (which, following assignment, shall be joint and 
several with the assignee), or relieve Tenant of any of its obligations 
hereunder without an express written release being given by Landlord.  In 
the event that Landlord shall consent to an assignment or subletting under 
this Article XIV, such assignment or subletting shall not be effective until 
the assignee or sublessee shall assume all of the obligations of this Lease 
on the part of Tenant to be performed or observed and whereby the assignee 
or sublessee shall agree that the provisions contained in this Lease shall, 
notwithstanding such assignment or subletting, continue to be binding upon 
it with respect to all future assignments and sublettings.  Such assignment 
or sublease agreement shall be duly executed and fully executed copy thereof 
shall be delivered to Landlord, and Landlord may collect Monthly Rent and 
Additional Rent due hereunder directly from the assignee or sublessee.  
Collection of Monthly Rent and Additional Rent directly from an assignee or 
sublessee shall not constitute a recognition of such assignee or sublessee 
as the Tenant hereunder or a release of Tenant from the performance of all 
of its obligations hereunder.

     14.3     Information.  Regardless of whether Landlord's consent is 
required under this Article XIV, Tenant shall notify Landlord in writing of 
Tenant's intent to assign this Lease or any right or interest hereunder, or 
to sublease the Premises or any part thereof, and of the name of the 
proposed assignee or sublessee, the nature of the proposed assignee's or 
sublessee's business to be conducted on the Premises, the terms and 
provisions of the proposed assignment or sublease, a copy of the proposed 
assignment or sublease form, and such other information as Landlord may 
reasonably request concerning the proposed assignee or sublessee including, 
but not limited to, net worth, income statements and other financial 
statements for a two-year period preceding Tenant's request for consent, 
evidence of insurance complying with the requirements of Article XI, a 
completed Environmental Questionnaire from the proposed assignee or 
sublessee, and the fee described in Section 14.7.

     14.4     Standard for Consent.  Landlord shall, within thirty (30) 
days of receipt of such Notice and all information requested by Landlord 
concerning the proposed assignee or sublessee, elect to take one of the 
following actions:

          (a)     consent to such proposed assignment or sublease;

          (b)     refuse to consent to such proposed assignment or sublease, 
which refusal shall be on reasonable grounds; or

          (c)     if Tenant proposes to sublease all or part of the Premises 
for the entire remaining Term, Landlord may, at its option exercised by 
thirty (30) days Notice to Tenant, elect to recapture such portion of the 
Premises as Tenant proposes to sublease and as of the thirtieth (30th) day 
after Landlord so notifies Tenant of its election to recapture, this Lease 
shall terminate as to the portion of the premises recaptured and the Monthly 
Rent payable under this Lease shall be reduced in the same proportion that 
the floor area of that portion of the Premises so recaptured bears to the 
floor area of the Premises prior to such recapture.

     Tenant agrees, by way of example and without limitation, that it shall 
not be unreasonable for Landlord to withhold its consent to a proposed 
assignment or subletting if any of the following situations exist or may 
exist:

               (i)     Landlord determines that the proposed assignee's or 
sublessee's use of the Premises conflicts with Article V or Article VI, 
presents an unacceptable risk, as determined by Landlord, under Article VI 
(and Landlord may require such assignee or sublessee to complete the 
Environmental Questionnaire in the manner described in Section 6.5 prior to 
making such determination), or conflicts with any other provision under this 
Lease;

               (ii)     Landlord determines that the proposed assignee or 
sublessee is not as financially responsible as Tenant as of the date of 
Tenant's request for consent or as of the effective date of such assignment 
or subletting;

               (iii)     Landlord determines that the proposed assignee or 
sublessee lacks sufficient business reputation or experience to conduct on 
the Premises a business of a type and quality equal to that conducted by 
Tenant;

               (iv)     Landlord determines that the proposed assignment or 
subletting would breach a covenant, condition or restriction in some other 
lease, financing agreement or other agreement relating to the Project, the 
Building, the Premises or this Lease;

               (v)     Landlord determines that the proposed assignee or 
sublessee (a) has been required by any prior landlord, lender or 

                                  -21-
<PAGE>

governmental authority to take remedial action in connection with Hazardous 
Materials contaminating a property if such contamination resulted from the 
proposed assignee's or sublessee's actions or use of the property in 
questions, or (b) is subject to any enforcement order issued by an 
governmental authority in connection with the use, disposal or storage of a 
Hazardous Material; or

               (vi)     An Event of Default has occurred and is continuing 
at the time of Tenant's request for Landlord's consent, or as of the 
effective date of such assignment or subletting.


          Tenant acknowledges that if Tenant has any exterior sign rights 
under this Lease, such rights are personal to Tenant and may not be assigned 
or transferred to any assignee of this Lease or sublessee of the Premises 
without Landlord's prior written consent, which consent may be withheld in 
Landlord's sole and absolute discretion.

     14.5     Bonus Value.  Tenant agrees that fifty percent (50%) of any 
amounts paid by the assignee or sublessee, however described, in excess of 
(i) the monthly Rent payable by Tenant hereunder (or, in the case of sublease 
of a portion of the Premises, in excess of the Monthly Rent reasonably 
allocable to such portion), plus (ii) Tenant's direct out-of-pocket costs 
which Tenant certifies to Landlord have been paid to provide occupancy-
related services to such assignee or sublessee of a nature commonly provided 
by landlords of similar space, shall be the property of Landlord and such 
amounts shall be payable directly to Landlord by the assignee or sublessee.  
At Landlord's request, a written agreement shall be entered into by and 
among Tenant, Landlord and the proposed assignee or sublessee confirming the 
requirements of this Section 14.5.

     14.6     Certain Transfers.  The sale of all or substantially all of 
Tenant's assets (other than bulk sales in the ordinary course of business), 
or, if Tenant is a corporation, an unincorporated association, or a 
partnership, the transfer, assignment or hypothecation of any stock or 
interest in such corporation, association or partnership in the aggregate in 
excess of fifty percent (50%) (except for publicly traded shares of stock 
constituting a transfer of fifty percent (50%) or more in the aggregate, so 
long as no change in the controlling interests of Tenant occurs as a result 
thereof) shall be deemed an assignment within the meaning and provisions of 
this Article XIV.

     14.7     Landlord's Fee and Expenses.  If Tenant requests Landlord's 
consent to an assignment or subletting by Tenant under this Lease, Tenant 
shall pay to Landlord a fee of Three Hundred Dollars ($300) and all of 
Landlord's out-of-pocket expenses including, but not limited to, attorneys' 
fees reasonably incurred related to such assignment or subletting by Tenant, 
whether or not the assignment or subletting is approved.

     14.8     Transfer of the Premises by Landlord.  Upon any conveyance 
of the Premises and assignment by Landlord of this Lease, Landlord shall and 
is hereby entirely released from all liability under any and all of its 
covenants and obligations contained in or derived from this Lease occurring 
after the date of such conveyance and assignment, and Tenant agrees to 
attorn to any entity purchasing or otherwise acquiring the Premises.


                                  ARTICLE XV

                            DEFAULTS AND REMEDIES

     15.1     Tenant's Default.  At the option of Landlord, a default under 
this Lease by Tenant shall exist if any of the following events shall occur 
(each is called an "Event of Default"):

          (a)     Tenant fails to pay the Rent payable hereunder, as and 
when due, for a period of three (3) days after Notice by Landlord; provided, 
however, the Notice given hereunder shall be in lieu of, and not in addition 
to, any notice required under Section 1161, et seq., of the California Code 
of Civil Procedure;

          (b)     Tenant attempts to make or suffers to be made any 
transfer, assignment or subletting, except as provided in Article XIV hereof;

          (c)     Any of Tenant's rights under this Lease are sold or 
otherwise transferred by or under court order or legal process or otherwise 
or if any of the actions described in Section 15.2 are taken by or against 
Tenant or any Guarantor;

                                  -22-
<PAGE>


          (d)     The Premises are used for any purpose other than as 
permitted pursuant to Article V;

          (e)     Tenant vacates or abandons the Premises or fails to 
continuously and uninterruptedly conduct its business in the Premises and 
thereafter fails to pay rent:

          (f)     Any representation or warranty given by Tenant under or in 
connection with this Lease proves to be materially false or misleading;

          (g)     Tenant fails to timely comply with the provisions of 
Article VI ("Hazardous Materials"), ArticleXIV ("Assignment and Subletting"), 
Article XVI ("Subordination; Estoppel Certificate; Financials"), Section 21.5 
("Modifications for Mortgagees") or Section 21.19 ("Authority"); or

          (h)     Tenant fails to observe, keep, perform or cure within 
thirty (30) days after Notice by Landlord any of the other terms, covenants, 
agreements or conditions contained in this Lease or those set forth in any 
other agreements or rules or regulations which Tenant is obligated to 
observe or perform.  In the event such default reasonably could not be cured 
or corrected within such thirty (30) day period, but is reasonably 
susceptible to cure or correction, then Tenant shall not be in default 
hereunder if Tenant commences the cure or correction of such default within 
such default within such thirty(30) day period and diligently prosecutes the 
same to completion after commencing such cure or correction.  The Notice 
required by his subparagraph15.1(h) shall be in lieu of, and not in addition 
to, any notice required under Section 1161, et seq., of the California Code 
of Civil Procedure.

Notices given under this Section 15.1 shall specify the alleged default and 
shall demand that Tenant perform the provisions of this Lease or pay the 
Rent that is in arrears, as the case may be, within the applicable period of 
time, or quit the Premises.  No such Notice shall be deemed a forfeiture or 
a termination of this Lease unless Landlord so elects in the Notice.

     15.2     Bankruptcy or Insolvency.  In no event shall this Lease be 
assigned or assignable by operation of law and in no event shall this Lease 
be an asset of Tenant in any receivership, bankruptcy, insolvency or 
reorganization proceeding.  In the event:

          (a)     A court makes or enters any decree or order adjudging 
Tenant to be insolvent, or approving as properly filed by or against Tenant 
a petition seeking reorganization or other arrangement of Tenant under any 
provisions of the Bankruptcy Code or any applicable state law, or directing 
the winding up or liquidation of Tenant and such decree or order shall have 
continued for a period of thirty (30) days;

          (b)     Tenant makes or suffers any transfer which constitutes a 
fraudulent or otherwise avoidable transfer under any provisions of the 
Bankruptcy Code or any applicable state law;

          (c)     Tenant generally assigns its assets for the benefit of its 
creditors; or

          (d)     The material part of the property of Tenant or any 
property essential to Tenant's business or of Tenant's interest in this 
Lease is sequestered, attached or executed upon, and Tenant fails to secure 
a return or release of such property within thirty (30) days thereafter, or 
prior to sale pursuant to such sequestration, attachment or levy, whichever 
is earlier.

          Then this Lease shall, at Landlord's election, immediately 
terminate and be of no further force or effect whatsoever, without the 
necessity for any further action by Landlord, except that Tenant shall not 
be relieved of obligations which have accrued prior to the date of such 
termination.  Upon such termination, the provisions herein relating to the 
expiration or earlier termination of this Lease shall control and Tenant 
shall immediately surrender the Premises in the condition required by the 
provisions of this Lease.  Additionally, Landlord shall be entitled to all 
relief, including recovery of damages from Tenant, which may from time to 
time be permitted, or recoverable, under the Bankruptcy Code or any other 
applicable state laws.

     15.3     Landlord's Remedies.  Upon the occurrence of an Event of 
Default, then, in addition to and without waiving any other rights and 
remedies available to Landlord at law or in equity or otherwise provided in 
this Lease, Landlord may, at its option, cumulatively or in the alternative, 
exercise the following remedies:

          (a)     Landlord may terminate Tenant's right to possession of the 
Premises, in which case this Lease shall terminate and Tenant shall 

                                  -23-
<PAGE>

immediately surrender possession of the Premises to Landlord.  No act by 
Landlord other than giving Notice to Tenant of Landlord's election to 
terminate Tenant's right to possession shall terminate this Lease.  Acts of 
maintenance, efforts to relet the Premises, or the appointment of a receiver 
on Landlord's initiative to protect Landlord's interest under this Lease 
shall not constitute a termination of Tenant's right to possession.  
Termination shall terminate Tenant's right to possession of the Premises, 
but shall not relieve Tenant of any obligation under this Lease which has 
accrued prior to the date of such termination.  Upon such termination, 
Landlord shall have the right to re-enter the Premises, and remove all 
persons and property, and Landlord shall also be entitled to recover from 
Tenant:

               (i)     The worth of the time of award of the unpaid Monthly 
Rent and Additional Rent which had been earned at the time of termination;

               (ii)     The worth at the time of award of the amount by 
which the unpaid Monthly Rent and Additional Rent which would have been 
earned after termination until the time of award exceeds the amount of such 
rental loss that Tenant proves could have been reasonably avoided;

               (iii)     The worth at the time of award of the amount by 
which the unpaid Monthly Rent and Additional Rent for the balance of the 
Term after the time of award exceeds the amount of such rental loss that 
Tenant proves could be reasonably avoided;

               (iv)     Any other amount necessary to compensate Landlord 
for all the detriment proximately caused by Tenant's failure to perform its 
obligations under this Lease or which in the ordinary course of things would 
be likely to result from Tenant's default including, but not limited to, the 
cost of recovering possession of the Premises, commissions and other 
expenses of reletting, the cost of rectifying any damage to the Premises 
occasioned by the act or omission of Tenant, reasonable attorneys' fees, and 
any other reasonable costs; and

               (v)     At Landlord's election, all other amounts in 
addition to or in lieu of the foregoing as may be permitted by law.

          As used in subsections (1) and (ii) above, the "worth at the 
time of award" shall be computed by discounting the amount at the discount 
rate of the Federal Reserve Bank of San Francisco at the time of award plus 
three percent (3%).

          (b)     Landlord may elect not to terminate Tenant's right to 
possession of the Premises, in which event this Lease will continue in full 
force and effect as long as Landlord does not terminate Tenant's right to 
possession, and Landlord may continue to enforce all of its rights and 
remedies under this Lease, including the right to collect all Rent as it 
becomes due.  In the event that Landlord elects to avail itself of the 
remedy provided by this subparagraph 15.3(b), Landlord shall not 
unreasonably withhold its consent to an assignment or subletting of the 
Premises subject to the reasonable standards for Landlord's consent as are 
contained in this Lease.  In addition, in the event Tenant has entered into 
a sublease which is valid under the terms of this Lease, Landlord may also, 
at its option, cause Tenant to assign to Landlord the interest of Tenant 
under said sublease including, but not limited to, Tenant's right to payment 
of Rent as it becomes due.  Landlord may elect to enter the Premises and 
relet them, or any part of them, to third parties for Tenant's account.  
Tenant shall be liable immediately to Landlord for all costs Landlord incurs 
in reletting the Premises including, but not limited to, broker's 
commissions, expenses of cleaning and remodeling the Premises required by 
the reletting, attorneys' fees and like costs.  Reletting can be for a 
period shorter or longer than the remaining Term of this Lease and for the 
entire Premises or any portion thereof.  Tenant shall pay to Landlord the 
Monthly Rent and Additional Rent due under this Lease on the dates the 
Monthly Rent and such Additional Rent are due, less the Rent Landlord 
actually collects from any reletting.  Except as provided in the preceding 
sentence, if Landlord relets the Premises or any portion thereof, such 
reletting shall not relieve Tenant of any obligation hereunder.  
Notwithstanding the above, no act by Landlord allowed by this subparagraph-
15.3(b) shall terminate this Lease unless Landlord notifies Tenant in 
writing that Landlord elects to terminate this Lease.

     15.4     No Surrender.  Tenant waives any right of redemption or relief 
from forfeiture under California Code of Civil Procedure, Sections 1174 and 
1179, or under any other present or future law in the event Tenant is 
evicted or Landlord or Landlord's Agents during the Term shall be deemed an 
acceptance of a surrender of the Premises, and no agreement to accept a 
surrender shall be valid unless in writing and signed by Landlord.  No 
employee of Landlord or of Landlord's Agent shall have any power to accept 

                                  -24-
<PAGE>

the keys to the Premises prior to the termination of this Lease, and the 
delivery of the keys to any employee shall not operate as a termination of 
this Lease or a surrender of the Premises.

     15.5     Interest on Late Payments.  Any Rent due under this Lease 
that is not paid to Landlord within five (5) days of the date when due shall 
commence to bear interest at the Applicable Rate until fully paid.  Neither 
the accrual nor the payment of interest shall cure any default by Tenant 
under this Lease.

     15.6     Attorneys' and Other Fees.  All sums reasonably incurred by 
Landlord in connection with an Event of Default or holding over of 
possession by Tenant after the expiration or termination of this Lease 
including, but not limited to, all reasonably costs, expenses and reasonable 
accountants', appraisers', attorneys' and other professional fees, and any 
collection agency or other collection charges, shall be due and payable by 
Tenant to Landlord on demand, and shall bear interest at the Applicable Rate 
from the date of such demand until paid by Tenant.  In addition, in the 
event that any action shall be instituted by either of the parties hereto 
for the enforcement of any of its rights in and under this Lease, the party 
in whose favor judgment shall be rendered shall be entitled to recover from 
the other party all expenses reasonably incurred by the prevailing party in 
such action, including actual costs and reasonable attorneys' fees.

     15.7     Landlord's Default.  Landlord shall not be deemed to be in 
default in the performance of any obligation required to be performed by it 
hereunder unless and until it has failed to perform such obligation within 
thirty (30) days after receipt of Notice by Tenant to Landlord (and the 
Mortgagees who have provided Tenant with notice) specifying the nature of 
such default; provided, however, that if the nature of Landlord's obligation 
is such that more than thirty (30) days are required for its performance, 
then Landlord shall not be deemed to be in default if it shall commence such 
performance within such thirty (30) day period and thereafter diligently 
prosecutes the same to completion.

     15.8     Limitation of Landlord's Liability.  The obligations of 
Landlord do not constitute the personal obligations of the individual 
limited partners if a partnership or if a corporation the, trustees, 
directors, officers or shareholders of Landlord or its constituent partners.  
If Landlord shall fail to perform any covenant, term, or condition of this 
Lease upon Landlord's part to be performed, Tenant shall be required to 
deliver to Landlord Notice of the same.  If, as a consequence of such 
default, Tenant shall recover a money judgment against Landlord, such 
judgment shall be satisfied only out of the proceeds of sale received upon 
execution of such judgment and levied thereon against the right, title and 
interest of Landlord in the Building and out of rent or other income from 
such property receivable by Landlord or out of consideration received by 
Landlord from the sale or other disposition of all or any part of Landlord's 
right, title or interest in the Building, and no action for any deficiency 
may be sought or obtained by Tenant.

     15.9     Mortgagee Protection.  Upon any default on the part of 
Landlord, Tenant will give notice by registered or certified mail to any 
Mortgagee who has provided Tenant with notice of its interest together with 
an address for receiving notice, and shall offer such Mortgagee a reasonable 
opportunity to cure the default (which in no event shall be less than sixty 
(60) days, including time to obtain possession of the Premises by power of 
sale or a judicial foreclosure, if such should prove necessary, to effect a 
cure.  Tenant agrees that each of the Mortgagees to whom this Lease has been 
assigned by Landlord is an express third-party beneficiary hereof.  Tenant 
shall not make any prepayment of Monthly Rent more than one (1) month in 
advance without the prior written consent of such Mortgagee.  Tenant waives 
any right under California Civil Code, Section 1950.7, or any other present 
or future law to the collection of any deposit from such Mortgagee or any 
purchaser at a foreclosure sale of such Mortgagee's interest unless such 
Mortgagee or such purchaser shall have actually received and not refunded 
the deposit.  Tenant agrees to make all payments under this Lease to the 
Mortgagee with the most senior encumbrance upon receiving a direction, in 
writing, to pay said amounts to such Mortgagee.  Tenant shall comply with 
such written direction to pay without determining whether an event of 
default exists under such Mortgagee's loan to Landlord.

     15.10     Landlord's Right to Perform.  If Tenant shall at any time 
fail to make any payment or perform any other act on its part to be made or 
performed under this Lease, Landlord may subject to Tenant's right to cure 
following notice under this Lease (but shall not be obligated to), at 
Tenant's expense, and without waiving or releasing Tenant from any 
obligation of Tenant under this Lease, make such payment or perform such 
other act to the extent Landlord may deem desirable, and in connection 
therewith, pay expenses and employ counsel.  All sums paid by Landlord and 
all penalties, interest and costs including, but not limited to, collection 

                                  -25-
<PAGE>

costs and attorneys' fees reasonably incurred in connection therewith, shall 
be due and payable by Tenant to Landlord, as an item of Additional Rent, on 
demand by Landlord, together with interest thereon at the Applicable Rate 
from the date of such demand until paid by Tenant.

     15.11     Limitation of Actions Against Landlord.  Any claim, demand 
or right of any kind by Tenant which is based upon or arises in connection 
with this Lease shall be barred unless Tenant commences an action thereon 
within one (1) year of the date of discovery by Tenant of the act, omission, 
event or default upon which the claim, demand or right arises, has occurred.

     15.12     Waiver of Jury Trial.  To the full extent permitted by law, 
the parties hereby waives the right to trial by jury in any action, 
proceeding or counterclaim brought by either party on any matter whatsoever 
arising out of or in any way connected with this Lease, the relationship of 
Landlord and Tenant, Tenant's use or occupancy of the Premises and/or any 
claim of injury or damage.


                                ARTICLE XVI

              SUBORDINATION; ESTOPPEL CERTIFICATE; FINANCIALS

     16.1     Subordination, Attornment and Non-Disturbance.  Without 
the necessity of any additional document being executed by Tenant for the 
purpose of effecting a subordination, and at the election of Landlord or any 
Mortgagee or any ground lessor with respect to the land of which the 
Premises are a part, this Lease shall be subject and subordinate at all 
times to (1) all ground leases or underlying leases which may now exist or 
hereafter be executed in any amount for which the Project, the Building, 
ground leases or underlying leases, or Landlord's interest or estate in any 
of said items is specified as security.  Landlord or any such Mortgagee or 
ground lessor shall have the right, at its election, to subordinate or cause 
to be subordinated any such ground leases or underlying leases or any such 
liens to this Lease.  No subordination shall permit material interference 
with Tenant's rights hereunder, and any ground lessor or Mortgagee shall 
recognize Tenant and its permitted successors and assigns as the tenant of 
the Premises and shall not disturb Tenant's right to quiet possession of the 
Premises during the Term so long as no Event of Default has occurred and is 
continuing under this Lease.  If Landlord's interest in the Premises is 
acquired by any ground lessor or Mortgagee, or in the event proceedings are 
brought for the foreclosure of, or in the event of exercise of the power of 
sale under, any Mortgage made by Landlord covering the Premises or any part 
thereof, or in the event a conveyance in lieu of foreclosure is made for any 
reason, Tenant shall, notwithstanding any subordination and upon the request 
of such successor in interest to Landlord, attorn to and become the Tenant 
of the successor in interest to Landlord and recognize such successor in 
interest as the Landlord under this Lease.  Although this Section 16.1 is 
self-executing, Tenant covenants and agrees to execute and deliver, upon 
demand by Landlord and in a commercially reasonable formor requested by 
Landlord, or any Mortgagee or ground lessor, any additional documents 
evidencing the priority or subordination of this Lease with respect to any 
such ground leases or underlying leases or the lien of any such Mortgage, or 
evidencing the attornment of Tenant to any successor in interest to Landlord 
as herein provided.  Tenant's failure to timely execute and deliver such 
additional documents shall, at Landlord's option, constitute an event of 
Default hereunder.

     16.2     Estoppel Certificate.  Tenant shall, within twenty (20) days 
following written request by Landlord, execute and deliver to Landlord any 
documents, including estoppel certificates, in a form reasonably required by 
Landlord (i) certifying that this Lease is unmodified and in full force and 
effect or, if modified, attaching a copy of such modification and certifying 
that this Lease, as so modified, is in full force and effect and the date to 
which the Rent and other charges are paid in advance, if any, (ii) 
acknowledging that there are not, to Tenant's knowledge, any uncured 
defaults on the part of the Landlord or stating the nature of any uncured 
defaults, (iii) evidencing the status of this Lease as may be required by a 
Mortgagee or a purchaser of the Premises, (iv)certifying the current Monthly 
Rent among and the amount and form of Security Deposit on deposit with 
Landlord, and (v) certifying to such other information as Landlord, 
Landlord's Agents, Mortgagees and prospective purchasers may reasonably 
request including, but not limited to, any requested information within the 
requirements of this Lease including Article 6 regarding Hazardous 
Materials.  Tenant's failure to deliver an estoppel certificate within 
twenty (20) days after delivery of Landlord's written request therefor shall 
constitute an Event of Default hereunder.

     16.3     Financial Information.  Tenant shall deliver to Landlord, 
prior to the execution of this Lease, and within ten (10) days following 

                                  -26-
<PAGE>

written request therefor by Landlord at any time during the Term, Tenant's 
current financial statements, and Tenant's financial statements for the two 
(2) years prior to the current fiscal financial statement's year, certified 
to be true, accurate and complete by the chief financial officer of Tenant, 
including a balance sheet and profit and loss statement for the most recent 
prior year (collectively, the "Statements"), which Statement shall 
accurately and completely reflect the financial condition of Tenant.  
Landlord agrees that it will keep the Statements confidential, except that 
Landlord shall have the right to deliver the same to any proposed purchaser 
of the Premises, the Project or any portion thereof, and to the Mortgagees 
of Landlord or such purchaser.  Tenant acknowledges that Landlord is relying 
on the Statements in its determination to enter into this Lease, and Tenant 
represents to Landlord, which representation shall be deemed made on the 
date of this Lease, that no material adverse change in the financial 
condition of Tenant, as reflected in the Statements, has occurred since the 
date Tenant delivered the Statements to Landlord.  If any material change in 
Tenant's financial condition, as reflected in the Statements, occurs prior 
to the date of this Lease, or if Tenant fails to inform Landlord of any such 
material change, Landlord shall have the right, in addition to any other 
rights and remedies of Landlord, to terminate this Lease by notice to Tenant 
given within fifteen (15) thirty (30) days after Landlord learns of such 
material change.


                               ARTICLE XVII

                           SIGNS AND GRAPHICS

     Landlord shall designate the location on the Premises for one (1) 
exterior identification sign for Tenant.  Tenant shall have no right to 
maintain identification signs in any other location in, or about the 
Premises (other than a sign on the entrance door) and shall not display or 
erect any other signs, displays or other advertising materials that are 
visible from the exterior of the Building.  The size, design, color and 
other physical aspects of the permitted sign shall be subject to Landlord's 
written approval prior to installation, which approval shall not be 
unreasonably withheld.  The cost of all signs and graphics, including the 
installation, maintenance and removal thereof, shall be at Tenant's sole 
cost and expense. Landlord shall ensure that the existing monument sign is 
blank and is in good condition and repair prior to Tenant's occupancy of the 
Premises. If Tenant fails to maintain its signs, or if Tenant fails to 
remove its name placard from the monument sign, upon termination of this 
Lease and repair any damage caused by such removal (including, but not 
limited to, repainting the affected area, if required by Landlord), Landlord 
may do so at Tenant's expense.  All sums reasonably disbursed, deposited or 
incurred by Landlord in connection with such removal including, but not 
limited to, all costs, expenses and actual attorneys' fees, shall be due and 
payable by Tenant by Landlord on deemed by Landlord, together with interest 
thereon at the Applicable Rate from the date of such demand until paid by 
Tenant.


                              ARTICLE XVIII

                             QUIET ENJOYMENT

     Landlord for itself and its successors in interest, covenants that 
Tenant, upon performing the terms, conditions and covenants of this Lease, 
shall have quiet and peaceful possession of the Premises as against nay 
person claiming the same by, through or under Landlord.

                               ARTICLE XIX

                         SURRENDER; HOLDING OVER

     19.1     Surrender of the Premises.  Upon the expiration or earlier 
termination of this Lease, Tenant shall surrender the Premises to Landlord 
in its condition existing as of the completion of the Work defined in the 
Workletter attached hereto as Exhibit "C", normal wear and tear and acts of 
God excepted, in a clean and broom swept condition with all interior walls 
in good repair,, the HVAC equipment, plumbing, electrical and other 
mechanical installations in good operating order, all to the reasonable 
satisfaction of Landlord.  Tenant shall remove from the Premises all of 
Tenant's Alterations which Landlord requires Tenant to remove pursuant to 
Section 8.1 and all Tenant's Personal Property, and shall repair any damage 
and perform any restoration work caused by such removal. If Tenant fails to 
remove such Alterations and Tenant's Personal Property which Tenant is 
authorized and obligated to remove pursuant to the above, and such failure 
continues after the termination of this Lease, Landlord any retain such 
property and all rights of Tenant with respect to it shall cease, or 
Landlord may place all or any portion of such property in public storage for 
Tenant's account.  Tenant shall pay to Landlord, upon demand, the costs of 

                                  -27-
<PAGE>

removal of any such Alterations and Tenant's Personal Property and storage 
and transportation costs of same, and the cost of repairing and restoring 
the Premises, together with attorneys' fees and interest on said amounts at 
the Applicable Rate from the date of expenditure by Landlord.  If the 
Premises are not so surrendered at the termination of this Lease, Tenant 
hereby agrees to indemnify Landlord and Landlord's Agents against all loss 
or liability resulting from any delay by Tenant in so surrendering the 
Premises.

     19.2     Holding Over.  If Tenant remains in possession of all or any 
part of the Premises after the expiration of the Term with the prior written 
consent of Landlord, such possession shall constitute a month-to-month 
tenancy only and shall not constitute a renewal or extension for any further 
term.  If Tenant remains in possession of all or any part of the Premises 
after the expiration of the Term without the prior written consent of 
Landlord, such possession shall constitute a tenancy at sufferance.  In 
either of such events, Monthly Rent shall be increased to an amount equal to 
one hundred twenty-five percent (125%) of the Monthly Rent payable during 
the last month of the Term, and any other sums due hereunder shall be 
payable in the amounts and at the times specified in this Lease.  Any such 
tenancy shall be subject to every other term, condition, and covenant 
contained in this Lease.


                                 ARTICLE XX

                    CONSTRUCTION OF TENANT IMPROVEMENTS

     The obligations of Landlord and Tenant, if any, with respect to the 
Tenant Improvements, are set forth in the Work Letter attached as ExhibitC.  
It is acknowledged and agreed that all Tenant Improvements under this Lease 
are and shall be the property of Landlord from and after their installation, 
Tenant's Personal Property excepted.

                                ARTICLE XXI

                MISCELLANEOUS AND INTERPRETIVE PROVISIONS

     21.1     Broker.  Landlord and Tenant each warrant and represent to the 
other that neither has had any dealings with any real estate broker, agent 
or finder in connection with the negotiation of this Lease or the 
introduction of the parties to this transaction, except for the Broker 
(whose commission shall be paid by Landlord), and that it knows of no other 
real estate broker, agent or finder who is or might be entitled to a 
commission or fee in connection with this Lease.  In the event of any 
additional claims for brokers' or finders' fees with respect to this Lease, 
Tenant shall indemnify, hold harmless, protect and defend Landlord from and 
against such claims if they shall be based upon any statement or 
representation or agreement made by Tenant, and Landlord shall indemnify, 
hold harmless, protect and defend Tenant from and against such claims if 
they shall be based upon any statement, representation or agreement made by 
Landlord.


     21.2     Examination of Lease.  Submission of this Lease for 
examination or signature by Tenant does not create a reservation of or 
option to lease.  This Lease shall become effective and binding only upon 
full execution of this Lease by both Landlord and Tenant.

     21.3     No Recording.  Tenant shall not record this Lease or any 
memorandum of this Lease without Landlord's prior written consent, but if 
Landlord so requests, Tenant agrees to execute, have acknowledged and 
deliver a memorandum of this Lease in recordable form which Landlord 
thereafter may file for record.

     21.4     Quitclaim.  Upon any termination of this Lease Tenant shall, at 
Landlord's request, execute, have acknowledged and deliver to Landlord an 
instrument in writing releasing and quitclaiming to Landlord all right, 
title and interest of Tenant in and to the Premises by reason of this Lease 
or otherwise.

     21.5     Modifications for Mortgagees.  If in connection with 
obtaining financing for the Premises or any portion thereof, Landlord's 
Mortgagees shall request reasonable modifications to this Lease as a 
condition to such financing, Tenant shall not unreasonably withhold, delay 
or defer its consent thereto, provided such modifications do not adversely 
affect Tenant's rights, unreasonably interfere with Tenant's use or 
enjoyment of the Premises, or increase the monetary obligations of Tenant 
hereunder.  Tenant's failure to so consent shall constitute an Event of 
Default under this Lease.

                                  -28-
<PAGE>

     21.6     Notice.  Any Notice required or desired to be given under this 
Lease shall be in writing and shall be addressed to the address of the party 
to be served.  The addresses of Landlord and Tenant are as set forth in 
Items 1 and 3, respectively, of the Basic Lease Provisions, except that (a) 
prior to the Commencement Date, the address for Notices to Tenant shall be 
as set forth opposite Tenant's signature on this Lease, and (b) from and 
after the Commencement Date, notwithstanding the addresses for Tenant set 
forth in Item 3 of the Basic Lease Provisions, all Notices regarding the 
operation and maintenance of the Project shall be delivered to Tenant at the 
Premises.  Each such Notice shall be deemed effective and given (a) upon 
receipt, if personally delivered (which shall include delivery by courier or 
overnight delivery service), (ii) upon being telephonically confirmed as 
transmitted, if sent by telegram, telex or telecopy, (iii) two (2) business 
days after deposit in the United States mail in orange County or in the 
count in which the Premises are located, certified and postage prepaid, 
properly addressed to the party to be served, or (iv) upon receipt if sent in 
any other way.  Any party hereto may from time to time, by Notice to the 
other in accordance with this Section 21.6, designate a different address 
than that set forth above for the purposes of Notice.

     21.7     Captions.  The captions and headings used in this Lease are for 
the purpose of convenience only and shall not be construed to limit or 
extend the meaning of any part of this Lease.

21.8     Executed Copy.  Any fully executed copy of this Lease shall be 
deemed an original for all purposes.

     21.9     Time.  Time is of the essence for the performance of each term, 
condition and covenant of this Lease.

     21.10     Severability.  If any one or more of the provisions contained 
herein shall for any reason be held to be invalid, illegal or unenforceable 
in any respect, such invalidity, illegality, or unenforceability shall not 
affect any other provision of this Lease, but this Lease shall be construed 
as if such invalid, illegal or unenforceable provision had not been 
contained herein.

     21.11     Survival.  All covenants and indemnities set forth herein which 
contemplate the payment of sums, or the performance by Tenant after the Term 
or following an Event of Default, including specifically, not limited to, 
the covenants and indemnities set forth in Section 5.3, Article VI, Article 
VII, Section 8.1, Section 9.2, Section 11.1, Section 11.9, Article XV, and 
Article XIX, and all representations and warranties of Tenant, shall survive 
the expiration or sooner termination of this Lease.

     21.12     Choice of Law.  This Lease shall be construed and enforced in 
accordance with the laws of the State of California.  The language in all 
parts of this Lease shall in all cases be construed as a whole according to 
its fair meaning and not strictly for or against either Landlord or Tenant.

     21.13     Gender; Singular, Plural.  When the context of this Lease 
requires, the neuter gender includes the masculine, the feminine, a 
partnership or corporation or joint venture, the singular includes the 
plural and the plural includes the singular.

     21.14     Non-Agency.  It is not the intention of Landlord or Tenant to 
create hereby a relationship of master-servant or principal-agent, and under 
no circumstance shall tenant herein be considered the agent of Landlord, it 
being the sole purpose and intent of the parties hereto to create a 
relationship of landlord and tenant.

     21.15     Successors.  The terms, covenants, conditions and agreements 
contained in this Lease shall, subject to the provisions as to assignment, 
subletting, and bankruptcy contained herein and any other provisions 
restricting successors or assigns, apply to and bind the heirs, successors, 
legal representatives and assigns of the parties hereto.

     21.16     Waiver; Remedies Cumulative.  The waiver by either party of 
any term, covenant, agreement or condition herein contained shall not be 
deemed to be a waiver of any subsequent breach of the same or any other 
term, covenant, agreement or condition herein contained, nor shall any 
custom or practice which may grow up between the parties in the 
administration of this Lease be construed to waive or to lessen the right of 
Landlord to insist upon the performance by Tenant in strict accordance with 
all of the provisions of this Lease.  The subsequent acceptance of Rent 
hereunder by Landlord shall not be deemed to be a waiver of any proceeding 
breach by Tenant of any provisions, covenant, agreement or condition of this 
Lease, other than the failure of Tenant to pay the particular Rent payment 
so accepted, regardless of Landlord's knowledge of such preceding breach at 
the time of acceptance of such Rent payment.  Landlord's acceptance of any 

                                  -29-
<PAGE>

check, letter of payment shall in no event be deemed an accord and 
satisfaction, and Landlord shall accept the check, letter or payment without 
prejudice to Landlord's right to recover the balance of the Rent or pursue 
any other remedy available to it.  The rights and remedies of either party 
under this Lease shall be cumulative and in addition to any and all other 
rights and remedies which either party has or may have.

     21.17     Unavoidable Delay.  Except for the monetary obligations of 
Tenant under this Lease, neither party shall be chargeable with, liable for, 
or responsible to the other for anything or in any amount for any 
Unavoidable Delay and any Unavoidable Delay shall not be deemed a breach of 
or default in the performance of this Lease, it being specifically agreed 
that any time limit provision contained in this Lease (other than the 
scheduled expiration of the Term) shall be extended for the same period of 
time lost by Unavoidable Delay.

     21.18     Entire Agreement.  This Lease is the entire agreement between 
the parties, and supersedes any prior agreements, representations, 
negotiations or correspondence between the parties, except as expressed 
herein.  Except as otherwise provided herein, no subsequent change or 
addition to this Lease shall be binding unless in writing and signed by the 
parties hereto.

     21.19     Authority.  If Tenant is a corporation or a partnership, each 
individual executing this Lease on behalf of the corporation or partnership, 
as the case may be, represents and warrants that he is duly authorized to 
execute and deliver this Lease on behalf of said entity in accordance with 
its corporate bylaws, statement of partnership or certificate of limited 
partnership, as the case may be, and that this Lease is binding upon said 
entity in accordance with its terms.  If Tenant is a corporation, Tenant 
shall, if requested by Landlord, within thirty (30) days after execution of 
this Lease and prior to entering into possession of the Premises, deliver to 
Landlord a certified copy of a resolution of the Board of Directors of the 
corporation or certificate of the Secretary of the corporation, authorizing, 
ratifying or confirming the execution of this Lease.  If Tenant is a 
partnership, Tenant shall, if requested by Landlord, within thirty (30) days 
after the execution of this Lease and prior to entering into possession of 
the Premises, deliver to Landlord a certified copy of this partnership 
agreement authorizing such execution.

     21.20     Guaranty.  All exhibits, amendments, riders and addenda 
attached to this Lease are hereby incorporated into and made a part of this 
Lease.  In the event of variation or discrepancy, the duplicate original 
hereof (including exhibits, amendments, riders and addenda, if any, 
specified above) held by Landlord shall control.  All references in this 
Lease to Articles, Sections, Exhibits, Riders and clauses are made, 
respectively, to Articles, Sections, Exhibits, Riders and clauses of this 
Lease, unless otherwise specified.

     21.22     Basic Lease Provisions.  The Basic Lease Provisions at the 
beginning of this Lease are intended to provide general information only.  
In the event of any inconsistency between the Basic Lease Provisions and the 
specific provisions of this Lease, the specific provisions of this Lease 
shall prevail.

     21.23     No Merger.  The voluntary or other surrender of this Lease by 
Tenant, or a mutual cancellation thereof, or a termination by Landlord, 
shall not work a merger, and shall, at the option of Landlord, terminate all 
or any existing subtenancies or may, at the option of Landlord, operate as 
an assignment to Landlord of any or all such subtenancies.

     21.24     Joint and Several Obligations.  If more than one person or 
entity is Tenant, the obligations imposed on each such person or entity 
shall be joint and several.

     21.25     No Light or Air Easement.  Any diminution or shutting off of 
light or air by any structure which may be erected on lands adjacent to the 
Building shall in no way affect this Lease, abate Rent or otherwise impose 
any liability on Landlord.  This Lease does not confer any right with regard 
to the subsurface below the ground level of the Building.

     21.26     Security Measures.  Tenant hereby acknowledges that Landlord 
shall have no obligation whatsoever to provide guard service or other 
security measures for the benefit of the Premises or the Project.  Tenant 
assumes all responsibility for the protection of Tenant, Tenant's Agents and 
the property of Tenant and of Tenant's Agents from acts of third parties.  
Nothing herein contained shall prevent Landlord, at Landlord's sole option, 
from providing security protection for the Project or any part thereof, in 
which event the cost thereof shall be included within the definition of 
Project Costs and paid by Tenant in the manner set forth in Section 7.1.

                                  -30-
<PAGE>


     THIS LEASE is effective as of the date the last signatory necessary to 
execute this Lease shall have executed this Lease.

                                "LANDLORD"

                                 Birtcher Property Services as Manager for 
                                 Scripps Jack, Ltd., a California corporation

                                 By:     _________________s/s_____________

                                 Name:   _________________s/s_____________

                                 Title:  _________________s/s_____________

                                 Date:   _________________s/s_____________

     
                                 By:     _________________s/s_____________

                                 Name:   _________________s/s_____________

                                 Title:  _________________s/s_____________
     
                                 Date:   _________________s/s_____________


                                 "TENANT"

                                 Agouron Pharmaceuticals, Inc., a California
                                 corporation

                                 By:     _________________s/s_____________

                                 Name:   _________________s/s_____________

                                 Title:  _________________s/s_____________

                                 Date:   _________________s/s_____________

     
                                 By:     _________________s/s_____________

                                 Name:   _________________s/s_____________

                                 Title:  _________________s/s_____________

                                 Date:   _________________s/s_____________



                                  -31-
<PAGE>

                                 EXHIBIT "A"
                       DESCRIPTION OF THE PREMISES

                                  -32-
<PAGE>

                                 EXHIBIT "B"

                           PROPERTY DESCRIPTION



The "Property" is that real property development known as Scripps-Sorrento 
Building, located at 4245 Sorrento Valley Blvd., San Diego, California.

The Property is further described as that certain improved real property, a 
diagram of which is attached as part of this exhibit, and which is described 
more particularly as: Parcel 1 of Parcel Map #12377 in the City of San 
Diego, County of San Diego, State of California, filed in the office of The 
County Recorder of San Diego County on October 18, 1982.

                                  -33-
<PAGE>


                                  EXHIBIT "C"

                                  WORK LETTER


THIS WORK LETTER AGREEMENT ("Workletter") is executed simultaneously with 
that certain Lease dated October 17, 1996 between Scripps Jack, Ltd., a 
California limited partnership, as Landlord, and Agouron Pharmaceuticals, 
Inc., as Tenant relating to demised premises ("Premises"), which Premises 
are more fully identified in the Lease.  Capitalized terms used herein, 
unless otherwise defined in this Workletter, shall have the respective 
meanings assigned to them in the Lease.

For and in consideration of the agreement to lease the Premises and the 
mutual covenants contained herein and in the Lease, Landlord and Tenant 
hereby agree as follows:

1.     Delivery of Premises.  Landlord delivered the Premises to Tenant 
pursuant to the Lease  and Tenant accepted the Premises in its "as is" 
condition, except for latent structural defects and Landlord's Construction 
Obligations as defined herein.

2.     Work.  Tenant, at its sole cost and expense, shall perform or cause to 
be performed the work (the "Work") in the Premises provided for in the Plans 
(as defined in Paragraph 3 hereof) submitted to and approved by Landlord, 
provided, however, that Tenant's work shall not include Tenant's furniture, 
furnishings, equipment or other interior decor.  Tenant's Work shall be 
constructed in a good and workmanlike fashion, in accordance with the 
requirements set forth herein and in compliance with all applicable laws, 
ordinances, rules and other governmental requirements.  Tenant shall 
commence the construction of the Work promptly following completion of the 
preconstruction activities provided for in Paragraph 3 below and shall 
diligently proceed with all such construction.  Tenant shall coordinate its 
work so as to avoid interference with any work being performed by or on 
behalf of Landlord and other tenants in the Project.

3.     Preconstruction Activities. 

     (a) As soon as reasonably possible, but in no event later than 
November 30, 1996, Tenant shall submit the following information and items 
to Landlord:

          (i)          a detailed construction schedule containing the 
major components of the Work and the time required for each, including the 
scheduled commencement date of construction of the Work, milestone dates and 
the estimated date of completion of construction;

          (ii)          an itemized statement of the estimated construction 
cost, including permit, architectural and engineering fees;

          (iii)          the names and addresses of Tenant's contractor (and 
the contractors' subcontractors) to be engaged by Tenant for the Work 
(collectively "Tenant's Contractors").  Landlord has approved David Begent & 
Co., Inc. as the contractor engaged by Tenant for the Work.

          (iv)          certificates of insurance as hereinafter described.  
Tenant shall not permit Tenant's Contractors to commence work until the 
required insurance has been obtained and certified copies of policies or 
certificates have been delivered to Landlord;

          (v)          the Plans for the Work, which Plans shall be subject 
to Landlord's approval in accordance with Paragraph 3(b) below.


Tenant will update such information and items by notice to Landlord of any 
changes.

     (b) As used herein, the term "Plans" shall mean the full and detailed 
final architectural and engineering plans and specifications covering the 
Work (including, without limitation, architectural, mechanical and 
electrical working drawings for the Work).  The Plans shall be subject to 
the approval of all local governmental authorities requiring approval, if 
any.  Landlord has given its approval of preliminary architectural drawings 
dated October 10, 1996 (SL-001; K-01a, -01b, -01c, -0d; K-02, 02a, -02b, -
02c, -02d; K-03a, -03b, -03c, 03d; k-04a) and the basis of design dated 
October 29,1996 (collectively the "Design Plan").  It is the intention of 
the parties that the Plans will reflect the design set forth in the Design 
Plan, and that completed Plans which are consistent with the Design Plan 
shall be deemed approved by the Landlord.  If changes are required to the 
Plans submitted by Tenant, (for example, if the Plans differ from the Design 

                                  -34-
<PAGE>

Plan) Tenant shall, within three (3) days thereafter, submit to Landlord for 
its approval the proposed revised Plans as amended in accordance with the 
changes so required.  The Plans shall also be revised, and the Work shall be 
changed, to incorporated any work required in the Premises by and local 
governmental field inspector.  Landlord's approval of the Plans shall in no 
way be deemed to be acceptance or approval of any element therein contained 
which is in violation of any applicable laws, ordinance, regulations or 
other governmental requirements or a representation or warranty that the 
Plans are adequate for any purpose. Landlord agrees that changes mandated 
solely by governmental authorities shall be acceptable and shall not require 
any further Landlord approval so long as such changes are implemented 
without adversely altering the Building's structure and in a manner 
reasonably acceptable to Landlord.

     (c) No Work shall be undertaken or commenced by Tenant in the  
Premises until:

          (i)     the Plans have been submitted to and approved by Landlord, 
except that Tenant can begin demolition prior to final Plan approval;

          (ii)     all required insurance coverages have been obtained by 
Tenant. (Failureof Landlord to receive evidence of such coverage upon 
commencement of the Work shall not waive Tenant's obligations to obtain such 
coverages.);

          (iii)     items required to be submitted to Landlord prior to 
commencement of construction of the Work have been so submitted and have 
been approved, where required;

          (iv)     Landlord has given written notice that the Work can 
proceed.

4.     Delay.  In the event Tenant fails to deliver or deliver in sufficient 
and accurate detail the information required under Paragraph 3 on or before 
the respective dates specified in said Paragraph, or in the event Tenant, 
for any reason, fails to complete the Work on or before the scheduled 
Commencement Date of the term of the Lease, Tenant shall be responsible for 
rent and all other obligations as set forth in the Lease from the 
Commencement Date under the Lease, regardless of the degree of completion of 
the Work on such date, and no such delay in completion of the Work shall 
relieve Tenant of any of its obligations under said Lease.

6.     Change Orders. All delays caused by Tenant-initiated change orders, 
including, without limitation, any stoppage of work during the change order 
review process, are solely the responsibility of Tenant and shall cause no 
delay in the commencement of the Lease or the rental and other obligations 
therein set forth.

7.     Standards of Design and Construction and Conditions of 
Tenant's Performance.  All work done in or upon the Premises by Tenant 
shall be done according to the standards set forth in this Paragraph 7, 
except as the same may be modified in the Plans approved by or on behalf of 
Landlord and Tenant.

     (a) Tenant's Plans and all design and construction of the Work shall 
comply with all applicable statutes, ordinances, regulations, laws, codes 
and industry standards.  Approval by Landlord of the Plans shall not 
constitute a waiver of this requirement or assumption by Landlord of 
responsibility for compliance.  Where several sets of the foregoing laws, 
codes and standards must be met, the strictest shall apply where not 
prohibited by another law, code or standard.

     (b) Tenant shall obtain, at its own cost and expense, all required 
building permits and, when construction has been completed, shall obtain, at 
its own cost and expense, an occupancy permit for the Premises, a copy of 
which permit shall be delivered to Landlord.

     (c) Tenant's Contractors shall be licensed contractors, possessing 
good labor relations, capable of performing quality workmanship and working 
in harmony with Landlord's contractors and subcontractors and with other 
contractors and subcontractors in the Building.  All work shall be 
coordinated with any other construction or other work in the Building or 
Project in order not to affect adversely construction work being performed 
by or for Landlord, it being understood that, in the event of any conflict, 
Landlord and its contractors and subcontractors shall have priority over 
Tenant and Tenant's Contractors.

     (d) Landlord shall have the right, but not the obligation, to perform 
on behalf of and for the account of Tenant, subject to reimbursement by 
Tenant, any work (i) which Landlord deems to be necessary on an emergency 
basis, (ii) which pertains to structural components, building systems or the 

                                  -35-
<PAGE>

general utility systems for the Building, or (iii) which pertains to the 
erection of temporary safety barricades or signs during construction.

     (e) Tenant shall use only new, first-class materials in the Work, 
except where explicitly shown otherwise in the Plans approved by Landlord 
and Tenant.  Tenant shall obtain warranties of at least one (1) year's 
duration from the completion of the Work against defects in workmanship and 
materials on all work performed and equipment installed in the Premises as 
part of the Work.

     (f) Tenant and Tenant's Contractors shall comply with all reasonable 
rules and regulations existing from time to time at the Project.  
Construction equipment and materials are to be kept within the Premises, and 
delivery and loading of equipment and materials shall be done at such 
locations and at such time as Landlord shall direct.

     (g) Landlord shall have the right to order Tenant or any of Tenant's 
Contractors who violate the requirements imposed on Tenant or Tenant's 
Contractors in performing work to cease work and remove its equipment and 
employees from the Building or Project.  No such action by Landlord shall 
delay the commencement of the Lease or the rental and other obligations 
therein set forth.

     (h) Tenant shall arrange and pay for removal of construction debris 
and shall not place debris in the Building's or Project's waste containers.

     (i) Tenant shall permit access to the Premises, and the Work shall be 
subject to inspection, by Landlord and Landlord's architects, engineers, 
contractors and other representatives at all times during the period in 
which the Work is being constructed and installed and following completion 
of the Work.

     (j) Tenant shall proceed with its work expeditiously, continuously and 
efficiently, and shall use its best efforts to complete the same as soon as 
reasonably possible.  Tenant shall notify Landlord upon completion of the 
Work and shall furnish Landlord with such further documentation as may be 
necessary under Paragraphs 9 below.

     (k) Tenant shall furnish to Landlord "as-built" drawings of the Work 
within thirty (30) days after completion of the Work.

     (l) Tenant shall impose on and enforce all applicable terms of this 
Workletter against Tenant's architect and Tenant's Contractors.

8.     Insurance and Indemnification.

       (a) In addition to any insurance which may be required under the 
Lease, Tenant shall secure, pay for and maintain or cause Tenant's 
Contractors to secure, pay for and maintain during the continuance of 
construction and fixturing work within the Building or Premises, insurance 
in the following minimum coverages and limits of liability:

          (i)     workers' compensation and employers' liability insurance 
with limits of not less than $500,000.00, or such higher amounts as may be 
required from time to time by any employee benefit acts or other statutes 
applicable where the work is to be performed, and in any event sufficient to 
protect Tenant's Contractors from liability under the aforementioned acts;

          (ii)     comprehensive or commercial general liability insurance 
(including contractors' protective liability) in an amount not less than 
$2,000,000.00 per occurrence, whether involving bodily injury liability (or 
death resulting therefrom) or property damage liability or a combination 
thereof with a minimum aggregate limit of not less than $10,000,000.00.  
Such insurance shall provide for explosion and collapse, completed 
operations coverage and broad form blanket contractual liability coverage 
and shall insure Tenant's Contractors against any and all claims for bodily 
injury, including death resulting therefrom, and damage to the property of 
others and arising from its operations under the contracts whether such 
operations are performed by Tenant's Contractors or by anyone directly or 
indirectly employed by any of them;

          (iii)     comprehensive automobile liability insurance, including 
the ownership, maintenance and operation of any automotive equipment, owned, 
hired or nonowned, in an amount not less than $500,000.00 for each person in 
one accident and $1,000,000.00 for injuries sustained by two or more persons 
in any one accident, and property damage liability in an amount not less 
than $1,000,000.00 for each accident.  Such insurance shall insure Tenant's 
Contractors against any and all claims for bodily injury, including death 
resulting therefrom, and damage to the property of others arising from its 
operations under the contracts, whether such operations are performed by 

                                  -36-
<PAGE>

Tenant's Contractors or by anyone directly or indirectly employed by any of 
them;

          (iv)     "all risk" builder's risk insurance upon the entire Work 
to the full insurable value thereof.  This insurance shall include the 
interests of Landlord and Tenant (and their respective contractors and 
subcontractors of any tier to the extent of any insurable interest therein) 
in the Work and shall insure against the perils of fire and extended 
coverage and shall include "all risk" builder's risk insurance for physical 
loss or damage including, without duplication of coverage, theft, vandalism 
and malicious mischief.  If portions of the Work are stored off the site of 
the Building or in transit to said site are not covered under said "all 
risk" builder's risk insurance, then Tenant shall effect and maintain 
similar property insurance on such portions of the Work.  Any loss insured 
under said "all risk" builder's risk insurance is to be adjusted with 
Landlord and Tenant and made payable to Landlord as trustee for the 
insureds, as their interests may appear.

All policies (except the workers' compensation policy) shall be endorsed to 
include as additional insured parties Landlord, the Mortgagees, and the 
Additional Insureds named in Item 16 of the Basic Lease Provisions  The 
waiver of subrogation provisions contained in the Lease shall apply to all 
insurance policies (except the workers' compensation policy) to be obtained 
by Tenant pursuant to this Paragraph.  The insurance policy endorsements 
shall also provide that all additional insured parties shall be given thirty 
(30) days' prior written notice of any cancellation or nonrenewal of 
coverage (except that ten (10) days' notice shall be sufficient in the case 
of cancellation for nonpayment of premium) and shall provide that the 
insurance coverage afforded to the additional insured parties thereunder 
shall be primary to any insurance carried independently by said additional 
insured parties.  Additionally, where applicable, each policy shall contain 
a cross-liability and severability of interest clause.

     (b) Without limitation of the indemnification provisions contained in 
the Lease, to the fullest extent permitted by law Tenant agrees to 
indemnify, protect, defend and hold harmless Landlord, Landlord's 
contractors and Landlord's architects and their partners, directors, 
officers, employees and agents, from and against all claims, liabilities, 
losses, damages and expenses of whatever nature arising out of or in 
connection with the Work or the entry of Tenant or Tenant's Contractors into 
the Project, the Building and the Premises, including, without limitation, 
mechanics' liens or the cost of any repairs to the Premises, Building or 
Project necessitated by activities of Tenant or Tenant's Contractors and 
bodily injury to persons or damage to the property of Tenant, its employees, 
agents, invitees or licensees or others.  It is understood and agreed that 
the foregoing indemnity shall be in addition to the insurance requirements 
set forth above and shall not be in discharge of or in substitution for same 
or any other indemnity or insurance provision of the Lease.

9.     Landlord's Contribution; Excess Amounts.

       (a) Upon completion of the work, Tenant shall furnish Landlord with 
final waivers of liens and contractors' affidavits, in such form as may be 
required by Landlord, from all parties performing labor or supplying 
materials or services in connection with the Work showing that all of said 
parties have been compensated in full and waiving all liens in connection 
with the Premises and Building. Tenant shall submit to Landlord a detailed 
breakdown of Tenant's total construction costs, together with such evidence 
of payment as is reasonably satisfactory to Landlord.

       (b) Upon completion of the Work and Tenant's satisfaction of all 
requirements set forth herein, Landlord shall make a dollar contribution in 
the amount of Three Hundred Ninety Five Thousand Dollars 
($395,000.00) ("Landlord's Contribution") for application to the extent 
thereof to the cost of the Plans and the Work.  If such costs of the Plans 
and the Work and exceeds Landlord's Contribution, Tenant solely shall have 
responsibility for the payment of such excess cost. If the cost of the 
Plans, and the Work is less than Landlord's Contribution, Landlord shall be 
entitled to retain such excess amount.  Notwithstanding anything herein to 
the contrary, Landlord may deduct from Landlord's Contribution any amounts 
due to Landlord or its architects or engineers under this Workletter.

     10. Miscellaneous.

     (a) Except as expressly set forth herein or in the Lease, Landlord has 
no agreement with Tenant and has no obligation to do any work with respect 
to the Premises.

     (b) If the Plans for the Work require the construction and 
installation of more fire hose cabinets or telephone/electrical closets than 
the number provided in the core of the Building in which the Premises are 

                                  -37-
<PAGE>

located, then Tenant agrees to pay all costs and expenses arising from the 
construction and installation of such additional fire hose cabinets or 
telephone/electrical closets.

     (c) Time is of the essence under this Workletter.

     (d) Any person signing this Workletter on behalf of Landlord and/or 
Tenant warrants and represents he has authority to do so.

     (e) If Tenant fails to make any payment relating to the Work as 
required hereunder, Landlord, at its option, may complete the work pursuant 
to the approved Plans and continue to hold Tenant liable for the costs 
thereof and all other costs due to Landlord.  Tenant's failure to pay any 
amounts owed by Tenant hereunder when due or Tenant's failure to perform its 
obligations hereunder shall also constitute a default under the Lease, and 
Landlord shall have all the rights and remedies granted to Landlord under 
the Lease for nonpayment of any amounts owed thereunder or failure by Tenant 
to perform its obligations thereunder.

     (f) Notices under this Workletter shall be given in the same manner as 
under the Lease.

     (g) The liability of Landlord hereunder or under any amendment hereto 
or any instrument or document executed in connection herewith (including, 
without limitation, the Lease) shall be limited to and enforceable solely 
against Landlord's interest in the Building.

     (h) The headings set forth herein are for convenience only.

                                  -38-
<PAGE>


     (i) This Workletter sets forth the entire agreement of Tenant and 
Landlord regarding the Work.  This Workletter may only be amended if in 
writing and duly executed by both Landlord and Tenant.


     IN WITNESS WHEREOF, this Workletter is executed as of the date and year 
first written above.

                                                       
                    "LANDLORD"

                         Birtcher Property Services as Manager for 
                         Scripps Jack, Ltd., a California corporation


                         By:/s/ Michael S. Buzar
                            -----------------------------------------
                         Name:_ Michael S. Buzar _
                         Title: Senior Vice President
                         Date:  11/13/96


                         By:/s/ Lynda L. Bettini, CPM
                            -----------------------------------------
                         Name:  Lynda L. Bettini, CPM
                         Title: Vice President
                         Date:  11/13/96

                         "TENANT"

                         Agouron Pharmaceuticals, Inc., 
                         a California corporation


                         By:/s/ Glenn Zinser
                            -----------------------------------------
                         Name:  Glenn Zinser
                         Title: Vice President, OperationS
                         Date:  November 8, 1996
                         

                         By:/s/ Gary Friedman
                            -----------------------------------------
                         Name:  Gary E. Friedman
                         Title: Vice President and General Counsel
                         Date:  November 8, 1996
      

                                  -39-
<PAGE>


                                 EXHIBIT "D"
                       COMMENCEMENT DATE MEMORANDUM



TO:                         DATED:___________________________
      


     "Tenant"

Re:  Office Lease dated __________________, 19__ , by and between ______
      

_____________________, as Landlord, and ________________________________
, 

as Tenant (the "Lease").

     Please acknowledge that the Commencement Date of the Lease is _________

, 19__ and that the Expiration Date of the Lease is _______________, 19__.

Very truly yours,



By:______________s/s______________

Its:______________________________

              "Landlord"


     Tenant hereby confirms the information set forth above, and further 
acknowledges that Landlord has fulfilled its obligations, if any, regarding 
the construction of Tenant's initial leasehold improvements under the 
above-referenced Lease.


By:______________s/s_____________

Its:_____________________________


Dated:______________________, 1996

             "Tenant"

                                  -40-
<PAGE>

                                 EXHIBIT "E"
                        ADJUSTMENT TO MONTHLY RENT




                                                         Monthly Rent
                                                        per Square Foot   
                                                           Of Gross
                  Period                                 Building Area   
  
May 15,1997 through and including December 31, 1997         $1.45

January 1, 1998 through and including December 31, 1998     $1.49
  
January 1, 1999 through and including December 31, 1999     $1.54

January 1, 2000 through and including December 31, 2000     $1.58

January 1, 2001 through and including December 31, 2001     $1.63


                                  -41-
<PAGE>

                                 EXHIBIT F
                           RULES AND REGULATIONS


     This Exhibit sets forth the rules and regulations governing 
Tenant's use of the Premises leased to Tenant pursuant to the terms, 
covenants and conditions of the Lease to which this Exhibit is attached and 
therein made part thereof.  Unless otherwise defined, capitalized terms used 
herein shall have the same meaning as set forth in the Lease.  In the event 
of any conflict or inconsistency between this Exhibit and the Lease, the 
Lease shall control.

     1.     Tenant shall not place anything or allow anything to be 
placed near the glass of any window, door, partition or wall which may 
appear unsightly from outside the Premises.

     2.     The walls, walkways, sidewalks, entrance passages, courts 
and vestibules shall not be obstructed or used for any purpose other than 
ingress and egress of pedestrian travel to and from the Premises, and shall 
not be used for loitering or gathering, or to display, store or place any 
merchandise, equipment or devices, or for any other purpose.  The walkways, 
entrance passageways, courts, vestibules and roof are not for the use of the 
general public and Landlord shall retain the right to control and prevent 
access thereto by all persons whose presence in the judgment of Landlord 
shall be prejudicial to the safety, character, reputation and interests of 
the Building and its tenants, provided that nothing therein contained shall 
be construed to prevent such access to persons with whom Tenant normally 
deals in the ordinary course of Tenant's business unless such persons are 
engaged in illegal activities.

     3.     No awning or other projection shall be attached to the 
outside walls of the Building.  No security bars or gates shall be installed 
without the prior written consent of Landlord, which consent shall not be 
unreasonably withheld.  Neither the interior nor exterior of any windows 
shall be coated or otherwise sunscreened without the express written consent 
of Landlord, which consent shall not be unreasonably withheld.

     4.     Tenant shall not in any way deface any part of the 
Premises or the Building.  The expense of repairing any damage resulting 
from a violation of this rule shall be borne by the Tenant.

     5.     The toilet rooms, urinals, wash bowls and other plumbing 
apparatus shall not be used for any purpose other than that for which they 
were constructed and no foreign substance or any kind whatsoever shall be 
thrown therein.  The expense for any breakage, stoppage or damage resulting 
from the violation of this rule shall be borne by the Tenant.

     6.     The Premises shall not be used for manufacturing, offices 
or the storage of merchandise except as the same me be incidental to the 
permitted use of the Premises.  No exterior storage shall be allowed at any 
time without prior written approval of Landlord.  The Premises shall not be 
used for cooking or washing clothes without the prior written consent of 
Landlord, or for lodging or sleeping or for any illegal purposes.

     7.     Tenant shall not make, or permit to be made, any unseemly 
or disturbing noises or disturb or interfere with the neighboring building 
or premises or those having business with them, whether by the use of any 
musical instrument, radio, phonograph, machinery, or otherwise.

     8.     Tenant shall not use the name of the Building or the 
Project in connection with or in promoting or advertising the business of 
Tenant, except as Tenant's address, without the prior written consent of 
Landlord.  Landlord shall have the right to prohibit any advertisement by 
Tenant which, in Landlord's reasonable opinion, tends to impair the 
reputation of the Project or its desirability for its intended use, and upon 
written notice from Landlord Tenant shall refrain from or discontinue such 
advertising.

     9.     Canvassing, soliciting, peddling, parading, picketing, 
demonstrating or otherwise engaging in any conduct that unreasonably impairs 
the value or use of the Premises or the Project are prohibited and Tenant 
shall cooperate to prevent the same.

     10.     All equipment of any electrical or mechanical nature shall 
be placed by Tenant on the Premises, in settings approved by Landlord in 
writing, in such a way as to best minimize, absorb and prevent any 
vibration, noise or annoyance.  No Equipment of any type shall be [placed on 
the Premises which in Landlord's opinion exceeds the load limits of the 
floor or otherwise threatens the soundness of the structure or improvements 
of the Building.

                                  -42-
<PAGE>

     11.     No aerial antenna shall be erected on the roof or exterior 
of the Premises, or on the rounds, without in each instance the prior 
written consent of Landlord.  Any aerial antenna so installed by or on 
behalf of Tenant without such written consent shall be subject to removal by 
Landlord at any time without prior notice at the expense of Tenant, and 
Tenant shall upon Landlord's demand pay a removal fee to Landlord of not 
less than $200.00.

     12.     The entire Premises, including vestibules, entrances, 
doors, fixtures, windows and plate glass, shall at all times be maintained 
in a safe, neat and clean condition by Tenant.  All trash, refuse and wastes 
materials shall be regularly removed from the Premises by Tenant and placed 
in the containers at the locations designated by Landlord for refuse 
collection.  All cardboard boxes must be "broken down" prior to being placed 
in the trash containers.  All Styrofoam chips must be bagged or otherwise 
contained prior to placement in the trash containers, so as not to 
constitute a nuisance.  Pallets may not be disposed of in the trash 
containers or enclosures.  The burning of trash, refuse or waste materials 
is prohibited.

     13.     Tenant shall use at Tenant's cost such pest extermination 
contractor as Landlord may direct and at such intervals as Landlord and 
Tenant determine necessary.

     14.     Tenant shall not change locks or install other locks on 
doors of the Premises, without the prior written consent of Landlord.  In 
the event of loss of any keys furnished by Landlord for Tenant, Tenant shall 
pay to Landlord the cost thereof.

     15.     No person shall enter or remain within the Project while 
intoxicated or under the influence of liquor or drugs.  Landlord shall have 
the right to exclude or expel from the Project any person who, in the 
absolute discretion of Landlord, is under the influence of liquor or drugs.

     Tenant agrees to comply with all such Rules and Regulations.  
Should Tenant not abide by these Rules and Regulations, Landlord may serve a 
three (3) day notice to correct the deficiencies.  If Tenant has not 
corrected the deficiencies by the end of the notice period, Tenant will be 
in default of the Lease, and Landlord and/or its designee shall have the 
right, without further notice, to cure the violation at Tenant's expense.

     Neither Landlord nor Landlord's Agents or any other person or 
entity shall be responsible to Tenant or to any other person for the 
ignorance or violation of these Rules and Regulations by any other tenant or 
other person.  Tenant shall be deemed to have read these Rules and 
Regulations and to have agreed to abide by them as a condition precedent, 
waivable only by Landlord, to Tenant's occupancy of the Premises.


                                  -43-
<PAGE>

                            RIDER NO.1 TO LEASE
                           DATED October 25, 1996
                              BY AND BETWEEN
Scripps Jack, Ltd., a California limited partnership, AS LANDLORD
Agouron Pharmaceuticals, Inc., a California corporation, AS TENANT

This Rider, dated as of October 17, 1996, is attached to and made a part of 
the above-described lease (the "Lease") between the above-named Landlord and 
Tenant.  Except as otherwise set forth in this Rider, all terms used in this 
Rider shall have the same meaning as when used in the foregoing portion of 
the Lease.  To the extent of any inconsistencies between the foregoing 
provisions of the Lease and the provisions of this Rider, the former are 
hereby amended.

OPTION TO EXTEND

     (a)     Option. Tenant shall have the right to extend the Term of the 
Lease for a period of sixty (60) months (the "Extension Period"), provided 
that Tenant (i) is not in actual default under any provision of the Lease, 
(ii) is occupying substantially all of the Premises, and (iii) has not 
assigned or subleased any portion of the Premises, unless otherwise approved 
by Landlord in other such assignment or sublease agreements.

     (b)     Exercise of Option. Tenant shall exercise its right to 
extend the Lease Term only by delivering written notice to Landlord or 
Tenant's desire to so extend the Lease Term no greater than 270 days nor 
less than 180 days prior to the commencement of each Extension Period (the 
"Extension Notice").

     (c)     New Lease Or Extension Amendment. Upon receipt of the 
Extension Notice, Landlord shall prepare and deliver to Tenant an amendment 
to this Lease (the "Extension Amendment") or, if Landlord is then utilizing 
a form of lease different from this Lease, Landlord shall deliver to Tenant 
a new lease (the "New Lease").  The Extension Amendment or New Lease shall 
provide for a Monthly Rental equal to the fair market rental for the 
Premises determined by Landlord according to the rental then being charges 
for comparable space within the Sorrento Mesa area.  Fair market rental as 
used above shall include increases from the initial option rental which are 
typically included in leases negotiated at that time.

     (d)     Objection to Landlord's Determination of Fair Market 
Rental. If Tenant objects to Landlord's determination of the fair market 
rental for the Premises, Landlord shall appoint a qualified Commercial Real 
Estate profession with at least ten (10) years of experience to appraise the 
Premises (the "Landlord's Appraisal") for the purpose of determining the 
fair market rental.  The Landlord's Appraisal shall be the fair market 
rental for the purpose of determining the Monthly Rental during the 
Extension Period.  Tenant shall (i) within five (5) days after the receipt 
of written notice of the Landlord's Appraisal employ and pay an MAI 
appraiser to determine the fair market rental for the Premises (the 
"Tenant's Appraisal"), and (ii) within twenty (20) days thereafter, submit 
to Landlord, Tenant's Appraisal together with a written summary of the 
methods used and data collected to make such determination.  If Landlord's 
Appraisal and Tenant's Appraisal differ by (i) less than ten percent (10%), 
the greater of the two shall be the fair market rental for the Premises or 
(ii) more than ten percent (10%), Landlord and Tenant shall promptly 
instruct its appraiser to jointly appoint a third MAI appraiser to determine 
the fair market rental for the Premises (the "Third Appraisal").  Landlord 
and Tenant shall each pay one-half (1/2) of the expenses of the Third 
Appraisal.  The appraisal among the three (3) that is furthest from the 
median of all of the appraisals shall be disregarded and the average of the 
other two shall be the fair market rental for the Premises and binding upon 
Landlord and Tenant.  Until appraisal procedures are final, Landlord and 
Tenant shall abide by the provisions of the Extension Amendment or New 
Lease.  Notwithstanding anything to the contrary herein, by giving written 
notice to Landlord within five (5) days of determination of the fair market 
rental by the appraiser(s), Tenant may withdraw the exercise of its option 
and pay the Landlord's share of appraisal fees, in which case the Lease Term 
shall terminate upon the Expiration Date.

     (e)     Time is of the Essence. Time shall be of the essence 
regarding all the periods set forth above for the exercise of the option, 
execution of the Extension Amendment or New Lease and the objection to the 
determination of the fair market rental for the Premises.  The failure of 
Tenant to timely exercise the option as provided in paragraphs (b) and (c) 
above shall cause this option to automatically cease and terminate, and, in 
such event, this Lease shall terminate without extension.  If Tenant or 
Landlord fail to timely comply with the provisions of paragraph (d), the 
Non-Complying Party shall be deemed to have accepted the fair market rental 
as determined by the Complying Party.


                                  -44-
<PAGE>

     (f)     It is understood and agreed that this option to extend is 
personal to Agouron Pharmaceuticals, Inc., a California corporation, and is 
not transferable; in the event of any assignment or subleasing of any or all 
of the Premises, this option to extend shall be null and void. 


                    "LANDLORD"

                         Birtcher Property Services as Manager for 
                         Scripps Jack, Ltd., a California corporation


                         By:/s/ Michael S. Buzar
                            -----------------------------------------
                         Name:_ Michael S. Buzar _
                         Title: Senior Vice President
                         Date:  11/13/96


                         By:/s/ Lynda L. Bettini, CPM
                            -----------------------------------------
                         Name:  Lynda L. Bettini, CPM
                         Title: Vice President
                         Date:  11/13/96

                         "TENANT"

                         Agouron Pharmaceuticals, Inc., 
                         a California corporation


                         By:/s/ Glenn Zinser
                            -----------------------------------------
                         Name:  Glenn Zinser
                         Title: Vice President, OperationS
                         Date:  November 8, 1996
                         

                         By:/s/ Gary Friedman
                            -----------------------------------------
                         Name:  Gary E. Friedman
                         Title: Vice President and General Counsel
                         Date:  November 8, 1996
      




                                                        EXHIBIT 10.67

                         AGOURON PHARMACEUTICALS, INC.
                          (a California Corporation)

                   1990 INCENTIVE STOCK OPTION AGREEMENT


     This Option Agreement is entered into between Agouron Pharmaceuticals, 
Inc., a California corporation and the Optionee whose name appears on the 
Notice of Grant of Stock Option to which this Agreement is an attachment.


1.     Recitals.

     1.01     The Board of Directors of the Company or its duly authorized 
delegates authorized the granting of this Option to Optionee who is an 
Employee of the Company or its Affiliates pursuant to the Agouron 
Pharmaceuticals, Inc. 1990 Stock Option Plan.

     1.02     This Option Agreement is intended to constitute an "incentive 
stock option" within the meaning of Section 422 of Internal Revenue Code of 
1986, as amended from time to time.


2.     Definitions.

     In addition to those words and phrases defined above and unless 
otherwise required by the context in which they appear, words and phrases 
having their initial letters capitalized shall have the following meanings:

     2.01     Act.  "Act" shall mean the Securities Exchange Act of 1934, as 
amended from time to time.

     2.02     Affiliate.  "Affiliate" shall mean any corporation defined as a 
"parent corporation" or a "subsidiary corporation" by Code Section 424(e) 
and (f), respectively.

     2.03     Agreement.  "Agreement" shall mean this 1990 Incentive Stock 
Option Agreement (including any schedules, attachments, documents 
incorporated by reference, or modifications agreed to in writing by the 
Company and Optionee) which sets forth the Optionee's and the Company's 
rights and obligations with respect to the Option granted Optionee by the 
Board or its duly authorized delegates as described on the Notice of Grant.

     2.04     Board.  "Board" shall mean the Board of Directors of the 
Company.

     2.05     Code.  "Code" shall mean the Internal Revenue Code of 1986, as 
amended.

<PAGE>

     2.06     Company.  "Company" shall mean Agouron Pharmaceuticals, Inc., a 
California corporation, and any successors or assigns.

     2.07     Date of Grant.  "Date of Grant" shall mean the Date of Grant 
set forth on the Notice of Grant.

     2.08     Disability. "Disability" or "Disabled" shall mean the condition 
of being "disabled" within the meaning of Section 422(c)(6) of the Code or 
any successor provision. 

     2.09     Employee.  "Employee" shall mean any salaried employee of the 
Company or its Affiliates, including those employees who are officers of the 
Company or its Affiliates.

     2.10     Expiration Date.  "Expiration Date" shall mean the Expiration 
Date set forth on the Notice of Grant.

     2.11     Fair Market Value.  "Fair Market Value" of Stock on a given 
date shall mean an amount per share, as determined by the Board or its 
delegates by applying any reasonable valuation method determined without 
regard to any restriction other than a restriction which, by its terms, will 
never lapse.  Notwithstanding the preceding, if the Stock is traded upon an 
established stock exchange or exchanges or quoted on the over-the-counter 
market as reported by the National Association of Securities Dealers 
Automated Quotation Systems ("NASDAQ") National Market System, then the "Fair 
Market Value" of Stock on a given date per share shall be deemed to be the 
average of the highest and lowest selling price per share of the Stock on the 
principal stock exchange on which the Stock is then trading, or on the over-
the-counter market as reported by NASDAQ National Market System on such 
date, or, if there was no trading of the Stock on that day, on the next 
preceding day on which there was such a trade; if the Stock is not traded 
upon an established stock exchange or quoted on the over-the-counter market 
as reported by NASDAQ National Market System but is quoted on the NASDAQ or 
a successor quotation system, the "Fair Market Value" of Stock on a given 
date shall be deemed to be the mean between the closing representative "bid" 
and "ask" prices per share of the Stock on such date as reported by the 
NASDAQ or such quotation system, or, if there shall have been no trading of 
the Stock on that day, on the next preceding day on which there was such 
trading.

     2.12     Notice of Grant of Stock Option.  "Notice of Grant of Stock 
Option" or "Notice of Grant" shall mean the Notice of Grant executed by the 
Company and the Optionee to which this Agreement is an attachment.

     2.13     Option.  "Option" shall mean the right of Optionee to purchase 
the number of shares of Stock set forth on the Notice of Grant in accordance 
with the terms and conditions of this Agreement.

     2.14     Optionee.  "Optionee" shall mean the person whose name is set 
forth on the Notice of Grant.

                                     -2-
<PAGE>

     2.15     Option Price.  "Option Price" shall mean the price per share of 
Stock to be paid by the Optionee upon exercise of the Option, which amount 
is set forth on the Notice of Grant.

     2.16     Option Stock.  "Option Stock" shall mean the total number of 
shares of Stock the Optionee shall be entitled to purchase pursuant to this 
Agreement, which number of shares is set forth on the Notice of Grant.

     2.17     Plan.  "Plan" shall mean the 1990 Agouron Pharmaceuticals, Inc. 
Stock Option Plan, as amended from time to time.

     2.18     Reporting Person.  "Reporting Person" shall mean an Optionee 
who is required to file statements relating to his or her beneficial 
ownership of Stock with the SEC pursuant to Section 16(a) of the Act.

     2.19     Rule 16b-3.  "Rule 16b-3" shall mean Rule 16b-3, as amended 
from time to time, promulgated by the SEC under the Act, and any successor 
thereto.

     2.20     SEC.  "SEC" shall mean the Securities and Exchange Commission.

     2.21     Stock.  "Stock" shall mean the no par common stock of the 
Company.

     2.22     Vesting.  "Vesting" shall mean the date(s) when all or a 
portion of the Option Stock becomes available for exercise.

     2.23     Vesting Schedule.  "Vesting Schedule" shall mean the Vesting 
Schedule set forth on the Notice of Grant which indicates on what dates all 
or a portion of the Option Stock becomes available for exercise.


3.     Option.

     3.01     Grant.  The Company hereby grants to Optionee an Option to 
purchase all or any part of the Option Stock on the terms and conditions set 
forth in this Agreement.  The Date of Grant shall be the Date of Grant set 
forth on the Notice of Grant.

     3.02     Purchase Price.  The purchase price per share of Stock to be 
paid upon the exercise of this Option shall be the Option Price set forth on 
the Notice of Grant.  This Option Price is deemed by the Board or its 
delegatees to be not less than the Fair Market Value of the Stock on the 
Date of Grant.

     3.03     Restrictions on Transfer.  This Option shall not be 
transferable by Optionee, other than by will or the laws of descent and 
distribution, and may be exercised during Optionee's lifetime only by 
Optionee; provided, however, that this Option may be transferred to a trust 
for the benefit of the Optionee or members of his immediate family, provided 
that such transfer does not violate the requirements of Rule 16b-3 and Code 
Section 422.  Upon any attempt to sell, assign, encumber or otherwise 
transfer this Option in violation of this Agreement, 

                                     -3-
<PAGE>

or upon the levy of any attachment or similar process upon this Option, this 
Option shall immediately become null and void.

     3.04     Modifications of Rights.  As set forth in Paragraph 6(l) of the 
Plan, the Board may modify (including, lowering the Option Price or 
converting this Option, which is an incentive stock option, into a non-
statutory stock option), extend or renew this Option (to the extent not 
previously exercised), or accept the surrender of this Option (to the extent 
not previously exercised) and authorize the granting of new Stock options in 
substitution therefor; provided, however, that no modification of this 
Option shall, without the consent of the Optionee, alter or impair any 
existing rights or obligations of Optionee under this Option.

     3.05     Changes in Company's Equity Structure; Recapitalization of 
Company.  Upon the occurrence of the capital and/or recapitalization 
transactions described in Paragraph 6(j) of the Plan, this Option (to the 
extent not previously exercised) shall be adjusted or modified as provided 
in Paragraph 6(j) of the Plan.  Notwithstanding any provision of this 
Agreement, the Company reserves the right to:

             (a)     make or enter into any adjustments, reclassifications, 
                     reorganizations or changes of its capital or business 
                     structure;

             (b)     merge or consolidate with other entities; or

             (c)     dissolve, liquidate or sell, or transfer all or any part 
                     of its business or assets.

     3.06     Shareholder's Rights.  Optionee shall have no rights as a 
shareholder with respect to any shares Optionee is entitled to purchase 
under this Option until the date of the issuance of a certificate for such 
shares.  No adjustment shall be made for dividends (ordinary or 
extraordinary, whether in cash, securities or other property) or 
distributions or other rights for which the record date is prior to the date 
of issuance of such certificate, except as provided in this Agreement or in 
the Plan.


4.     Employment Conditions.

     4.01     Employment Status.  Optionee shall be considered to be in the 
employment of the Company as long as Optionee remains an Employee of the 
Company or its Affiliates.  The Board exclusively shall determine:

              (a)     whether or when there has been a termination of 
                      Optionee's employment;

              (b)     if there has been a failure to comply with Optionee's 
                      covenant not to compete obligations; and 

                                     -4-
<PAGE>

              (c)     the cause of such termination, 

which determination shall be final.

     4.02     Covenant Not to Compete.  Unless otherwise permitted in 
writing, Optionee, who is an Employee of the Company or its Affiliates, shall 
devote his entire time, energy and skill to the service of the Company or its 
Affiliates, subject to vacation, sick leave and other approved absences.  
Failure of Optionee to comply with the covenant not to compete obligations 
stated above within thirty (30) days of written notice of such failure shall 
cause, on the thirtieth (30th) day after such written notice, the 
cancellation of Optionee's right to purchase Option Stock (to the extent not 
previously exercised) without further action by the Company.

     4.03     Termination for Cause.  Unless otherwise agreed to by the 
Board, if Optionee's employment is terminated for cause, the right of 
Optionee to purchase Option Stock shall only be exercisable by Optionee for a 
period of thirty (30) days after the date of such termination.


5.     Exercise.

     5.01     Exercise Amounts.  Subject to the earlier termination of the 
right to exercise this Option as provided under this Agreement, including 
Paragraphs 4.02 and 4.03 above, the Optionee shall be entitled to exercise 
the amounts of Option Stock, in whole or in part, as set forth in the 
Vesting Schedule on the Notice of Grant.

     5.02     Additional Adjustments.  Notwithstanding the terms of Paragraph 
5.01 of this Agreement, the Board in its sole and exclusive discretion may 
provide for conditions for the exercise of this Option and/or modify the 
Vesting Schedule set forth on the Notice of Grant; provided, however, the 
Board may only modify the conditions for the exercise of this Option and/or 
modify the Vesting Schedule to provide for a more restrictive Vesting 
Schedule with the consent of Optionee, if such modification alters or 
impairs any existing rights or obligations of Optionee under this Option.  

     5.03     Cumulative Exercise Rights.  If the Optionee does not exercise 
in any one year period the full number of shares to which he is then 
entitled to exercise, he may exercise those shares in any subsequent year 
prior to the Expiration Date of this Option as set forth on the Notice of 
Grant, or such later date subsequently approved by the Board or its 
delegates.

     5.04     Expiration of Exercise Rights.  Subject to the provisions of 
Paragraph 5.08, in no event shall this Option be exercisable after the 
Expiration Date or such later date subsequently approved by the Board or its 
delegates; provided, however, that this Option shall expire and not be 
exercisable after the expiration of ten (10) years from the Date of Grant.

     5.05     Fractional Shares.  This Option shall not be exercisable with 
respect to any fractional shares of the Stock.

                                     -5-
<PAGE>

     5.06     Exercise Procedure.  This Option shall be exercised by the 
giving of written notice of exercise to the Company which specifies the 
number of shares of Stock to be purchased, accompanied by payment (in 
accordance with the terms of Paragraph 6(d) of the Plan) of the aggregate 
Option Price for the shares of Stock being purchased, such payment to be 
made in any combination of:

              (a)     United States cash currency;

              (b)     a cashier's or certified check to the order of the 
                      Company;

              (c)     a personal check acceptable to the Company;

              (d)     to the extent permitted by the Board, shares of Stock 
                      (including previously owned Stock or Stock issuable in 
                      connection with the Option exercise), properly endorsed 
                      to the Company, whose Fair Market Value on the date of 
                      exercise equals the aggregate Option Price of the 
                      Option being exercised; or

              (e)     to the extent agreed to by the Board, the Optionee's 
                      entering into an agreement with the Company whereby a 
                      portion of the Optionee's Options are terminated and 
                      where the "built-in gain" on any Options which are 
                      terminated as part of such agreement equals the 
                      aggregate Option Price of the Option being exercised. 
                      "Built-in gain" means the excess of the aggregate Fair 
                      Market Value of any Stock otherwise issuable on 
                      exercise of a terminated Option, over the aggregate 
                      Option Price otherwise due the Company on such 
                      exercise;

provided, however, that the form of payment which Optionee selects shall be 
permissible under the Code Section 422.  The Board (in accordance with the 
terms of Paragraph 6(d) of the Plan) may provide such assistance to the 
Optionee to facilitate the exercise of this Option as it deems appropriate; 
provided, however, that the Board, as a prerequisite to providing such 
assistance, may require satisfaction of any rules or conditions it deems 
appropriate.  Shares of Stock used to pay the Option Price shall be valued 
at their Fair Market Value on the date of exercise.  The Optionee's notice 
of exercise shall also be accompanied by payment (in accordance with the 
terms of Paragraph 6(p) of the Plan) of the amount of federal and state 
income and employment taxes that the Company is required to collect from 
Optionee because of the exercise of the Option.

     5.07     Exercise During Life.  Subject to the provisions of Paragraphs 
4.02, 4.03, 5.04 and 5.08, during Optionee's lifetime, this Option shall be 
exercisable only by Optionee either:

              (a)     while Optionee is employed by the Company or its 
                      Affiliates;

              (b)     within three (3) months after the date on which 
                      Optionee's employment terminates for reasons other than 
                      "termination for cause" as provided in Paragraph 4.03 
                      of this Agreement; or

                                     -6-
<PAGE>

              (c)     within one (1) year after the date on which the 
                      Optionee's employment terminates due to a Disability;

provided, however, that in no event shall the period of exercise be extended 
beyond the Expiration Date.  Unless the Board or its delegates otherwise 
agree, if Optionee is entitled to purchase shares of Stock after the 
termination of Optionee's employment, the number of shares of Stock Optionee 
may so purchase shall be limited to the number of shares of Stock Optionee 
was entitled to purchase as of such date of termination.

     5.08     Exercise After Death.  If Optionee dies while employed by or 
while serving as an officer or director of the Company or its Affiliates or 
within a period of three (3) months after the date such employment, but 
prior to the complete exercise of this Option, the Option may be exercised 
within one (1) year from the date of Optionee's death, but:

              (a)     only by a personal representative of Optionee, or by 
                      any person or persons who shall have acquired the 
                      Option directly from the Optionee by bequest or 
                      inheritance; and

              (b)     only to the extent that the Option was exercisable on 
                      the date of death and had not previously been 
                      exercised.

     5.09     Consultancy to the Company or Service as a Corporate Officer 
After Termination of Employment.  If Optionee acts as a consultant or 
corporate officer for the Company or its Affiliates after the termination of 
his employment, then Optionee shall not be deemed to have terminated his 
employment for the Company or its Affiliates for the purposes of Paragraphs 
5.07 and 5.08 of this Agreement until he ceases to be a consultant or 
corporate officer for the Company or its Affiliates, provided he does not 
violate any covenant not to compete obligations contained in his employment 
or consulting agreement with the Company or its Affiliates.  Notwithstanding 
Optionee not being deemed to have terminated his employment for the Company 
or its Affiliates pursuant to the terms of the preceding sentence, this 
Option, which is an incentive stock option, shall automatically convert into 
a non-statutory stock option three (3) months after the date on which 
Optionee actually terminates his or her employment with the Company or its 
Affiliates (one (1) year if the Optionee is Disabled on the date of 
termination).

     5.10     Exercise of Option Prior to Vesting.  The Board, in its sole 
and exclusive discretion, may permit the Optionee to exercise this Option 
prior to the date this Option is otherwise exercisable, provided the Stock 
issued on such exercise is subject to repurchase rights which expire pro rata 
as the Option would otherwise have become exercisable.

     5.11     Non-Sequential Exercise Permitted.  Subject to the exercise 
limitations set forth herein, this Option shall be exercisable 
notwithstanding the fact that there is an outstanding incentive stock option 
or non-statutory stock option for the purchase of Stock of the Company which 
was granted before this Option was granted, and no subsequently-granted 
incentive stock option shall fail to be exercisable solely because this 
Option remains outstanding.

                                     -7-
<PAGE>

     5.12     Legends.  Certificates for shares of Stock acquired upon 
exercise of this Option may contain such legends and transfer restrictions 
as the Company shall deem reasonably necessary or desirable to:  

              (a)     assure the satisfaction of any liability that the 
                      Company may or will have incurred for withholding of 
                      any federal and state income and employment taxes; 

              (b)     facilitate compliance by the Company with any federal 
                      or state laws or regulations, including, without 
                      limitation, legends restricting transfer of the Stock 
                      until there has been compliance with federal and state 
                      securities laws; 

              (c)     assure notice of the Company's repurchase rights under 
                      Paragraph 5.10 of this Agreement; or 

              (d)     assure notice of such other restrictions as may be 
                      imposed on the Stock under the terms of this Agreement.


6.     Conflict Between Plan and Agreement.

     This Agreement, including the Option and Optionee's rights hereunder, 
is subject to and governed by the Plan.  Any conflict between the terms and 
provisions of this Agreement and the terms and provisions of the Plan shall 
be governed by the terms and provisions of the Plan.


7.     Investment Intent.

     This Option is granted on the condition that Optionee's purchase of 
Stock shall be for investment purposes for Optionee's own account and not 
with a view to resale or distribution.  The Company shall not, upon the 
exercise of this Option, be required to issue or deliver shares of Stock or 
certificates therefor if, in the opinion of counsel for the Company, such 
issuance or delivery would be in violation of, or would not comply with, any 
applicable state or federal securities law, regulation or rule.


8.     Notices.

     8.01     In Writing.  All notices, demands, requests, declarations, 
service of process, or other communications permitted or required under this 
Agreement or applicable law shall be in writing.

     8.02     Delivery.  All such communications may be served personally or 
may be sent by registered or certified mail, return receipt requested, 
postage prepaid and addressed to either Optionee or the Company at the 
addresses appearing at the top of the Notice of Grant, or at such other 
address as either party shall have communicated to the other pursuant to 
this Paragraph 

                                     -8-
<PAGE>
8.02.  All such communications shall be deemed effectively 
delivered upon personal service or three (3) days after deposit in the 
United States Mail.


9.     Miscellaneous.

     9.01     Successors and Assigns.  Except as otherwise provided in this 
Agreement, this Agreement shall inure to the benefit of only the Company, 
Optionee and their respective successors or assigns.

     9.02     Status.  Nothing contained in this Agreement shall be construed 
as giving Optionee any right to be retained as an Employee, officer or 
director of the Company.

     9.03     Severability.  If any provision or provisions of this Agreement 
are adjudged to be, for any reason, unenforceable, illegal or void, the 
remainder of the provisions shall remain in full force and effect.

     9.04     Integration.  This Agreement and the Notice of Grant to which 
this Agreement is an attachment constitute the entire understanding of the 
parties concerning this Option.  Except as otherwise provided, any changes, 
modifications, variations, or subordinations pertaining to this Agreement 
and the Notice of Grant are invalid, unless stated in writing and executed 
by the Company and Optionee.

     9.05     Governing Law.  This Agreement and the Option granted hereby 
shall be governed by the laws of the State of California.

     9.06     Attorneys' Fees.  If either party brings an action or seeks to 
enforce or interpret any of the terms or provisions of this Agreement, the 
prevailing party shall be entitled to recover its reasonable attorneys' fees 
and costs, in addition to any other remedy it may be awarded.

     9.07     Counterparts.  This Agreement may be executed in counterparts, 
and the counterparts shall constitute the whole instrument.

     9.08     Titles for Convenience; Gender; and Plurals.  Titles of articles 
and paragraph headings are for convenience only and shall not affect the 
construction or interpretation of this Agreement, or any portion thereof.  
Whenever required by the context hereof, the singular shall include the 
plural, and vice versa; the masculine gender shall include the feminine and 
neuter, and vice versa.


                                     -9-
<PAGE>








                                                        EXHIBIT 10.68

                           AGOURON PHARMACEUTICALS, INC.
                           (a California Corporation)


                   1990 NON-STATUTORY STOCK OPTION AGREEMENT
                                      FOR
                      EMPLOYEES, OFFICERS AND DIRECTORS


     This Option Agreement is entered into between Agouron Pharmaceuticals, 
Inc., a California corporation and the Optionee whose name appears on the 
Notice of Grant of Stock Option to which this Agreement is an attachment.


1.     Recitals.

     1.01     The Board of Directors of the Company or its duly authorized 
delegates authorized the granting of this Option to Optionee pursuant to the 
Agouron Pharmaceuticals, Inc. 1990 Stock Option Plan.

     1.02     This Option Agreement is intended to constitute a non-statutory 
stock option, meaning an option which is not an "incentive stock option" 
within the meaning of Section 422 of Internal Revenue Code of 1986, as 
amended from time to time.


2.     Definitions.

     In addition to those words and phrases defined above and unless 
otherwise required by the context in which they appear, words and phrases 
having their initial letters capitalized shall have the following meanings:

     2.01     Act.  "Act" shall mean the Securities Exchange Act of 1934, as 
amended from time to time.

     2.02     Affiliate.  "Affiliate" shall mean any corporation defined as a 
"parent corporation" or a "subsidiary corporation" by Code Section 424(e) 
and (f), respectively.

     2.03     Agreement.  "Agreement" shall mean this 1990 Non-Statutory 
Stock Option Agreement (including any schedules, attachments, documents 
incorporated by reference, or modifications agreed to in writing by the 
Company and Optionee) which sets forth the Optionee's and the Company's 
rights and obligations with respect to the Option granted Optionee by the 
Board or its duly authorized delegates as described on the Notice of Grant.

     2.04     Board.  "Board" shall mean the Board of Directors of the 
Company.

                                    
<PAGE> 

     2.05     Code.  "Code" shall mean the Internal Revenue Code of 1986, as 
amended.

     2.06     Company.  "Company" shall mean Agouron Pharmaceuticals, Inc., a 
California corporation, and any successors or assigns.

     2.07     Date of Grant.  "Date of Grant" shall mean the Date of Grant 
set forth on the Notice of Grant.

     2.08     Disability.  "Disability" or "Disabled" shall mean the 
condition of being "disabled" within the meaning of Section 422(c)(6) of the 
Code or any successor provision. 

     2.09     Employee.  "Employee" shall mean any salaried employee of the 
Company or its Affiliates, including those employees who are officers of the 
Company or its Affiliates.

     2.10     Expiration Date.  "Expiration Date" shall mean the Expiration 
Date set forth on the Notice of Grant.

     2.11     Fair Market Value.  "Fair Market Value" of Stock on a given 
date shall mean an amount per share, as determined by the Board or its 
delegates by applying any reasonable valuation method determined without 
regard to any restriction other than a restriction which, by its terms, will 
never lapse.  Notwithstanding the preceding, if the Stock is traded upon an 
established stock exchange or exchanges or quoted on the over-the-counter 
market as reported by the National Association of Securities Dealers 
Automated Quotation Systems ("NASDAQ") National Market System, then the "Fair 
Market Value" of Stock on a given date per share shall be deemed to be the 
average of the highest and lowest selling price per share of the Stock on the 
principal stock exchange on which the Stock is then trading or on the over-
the-counter market as reported by NASDAQ National Market System on such 
date, or, if there was no trading of the Stock on that day, on the next 
preceding day on which there was such a trade; if the Stock is not traded 
upon an established stock exchange or quoted on the over-the-counter market 
as reported by NASDAQ National Market System but is quoted on the NASDAQ or 
a successor quotation system, the "Fair Market Value" of Stock on a given 
date shall be deemed to be the mean between the closing representative "bid" 
and "ask" prices per share of the Stock on such date as reported by the 
NASDAQ or such quotation system, or, if there shall have been no trading of 
the Stock on that day, on the next preceding day on which there was such 
trading.

     2.12     Notice of Grant of Stock Option.  "Notice of Grant of Stock 
Option" or "Notice of Grant" shall mean the Notice of Grant executed by the 
Company and the Optionee to which this Agreement is an attachment.

     2.13     Option.  "Option" shall mean the right of Optionee to purchase 
the number of shares of Stock set forth on the Notice of Grant in accordance 
with the terms and conditions of this Agreement.

     2.14     Optionee.  "Optionee" shall mean the person whose name is set 
forth on the Notice of Grant.

                                    -2-
<PAGE> 

     2.15     Option Price.  "Option Price" shall mean the price per share of 
Stock to be paid by the Optionee upon exercise of the Option, which amount 
is set forth on the Notice of Grant.

     2.16     Option Stock.  "Option Stock" shall mean the total number of 
shares of Stock the Optionee shall be entitled to purchase pursuant to this 
Agreement, which number of shares is set forth on the Notice of Grant.

     2.17     Plan.  "Plan" shall mean the 1990 Agouron Pharmaceuticals, Inc. 
Stock Option Plan, as amended from time to time.

     2.18     Reporting Person.  "Reporting Person" shall mean an Optionee 
who is required to file statements relating to his or her beneficial 
ownership of Stock with the SEC pursuant to Section 16(a) of the Act.

     2.19     Rule 16b-3.  "Rule 16b-3" shall mean Rule 16b-3, as amended from 
time to time, promulgated by the SEC under the Act, and any successor 
thereto.

     2.20     SEC.  "SEC" shall mean the Securities and Exchange Commission.

     2.21     Stock.  "Stock" shall mean the no par common stock of the 
Company.

     2.22     Vesting.  "Vesting" shall mean the date(s) when all or a portion 
of the Option Stock becomes available for exercise.

     2.23     Vesting Schedule.  "Vesting Schedule" shall mean the Vesting 
Schedule set forth on the Notice of Grant which indicates on what dates all 
or a portion of the Option Stock becomes available for exercise.


3.     Option.

     3.01     Grant.  The Company hereby grants to Optionee an Option to 
purchase all or any part of the Option Stock on the terms and conditions set 
forth in this Agreement.  The Date of Grant shall be the Date of Grant set 
forth on the Notice of Grant.

     3.02     Purchase Price.  The purchase price per share of Stock to be 
paid upon the exercise of this Option shall be the Option Price set forth on 
the Notice of Grant.

     3.03     Restrictions on Transfer.  This Option may be transferred to a 
trust for the benefit of the Optionee or members of his immediate family.  
Upon any attempt to sell, assign, encumber or otherwise transfer this Option 
in violation of this Agreement, or upon the levy of any attachment or 
similar process upon this Option, this Option shall immediately become null 
and void.

                                    -3-
<PAGE> 

     3.04     Modifications of Rights.  As set forth in Paragraph 6(l) of the 
Plan, the Board may modify (including, lowering the Option Price), extend or 
renew this Option (to the extent not previously exercised), or accept the 
surrender of this Option (to the extent not previously exercised) and 
authorize the granting of a new Stock option in substitution therefor; 
provided, however, that no modification of this Option shall, without the 
consent of the Optionee, alter or impair any existing rights or obligations 
of Optionee under this Option.

     3.05     Changes in Company's Equity Structure; Recapitalization of 
Company.  Upon the occurrence of the capital and/or recapitalization 
transactions described in Paragraph 6(j) of the Plan, this Option (to the 
extent not previously exercised) shall be adjusted or modified as provided 
in Paragraph 6(j) of the Plan.  Notwithstanding any provision of this 
Agreement, the Company reserves the right to:

(a)     make or enter into any adjustments, reclassifications, reorganizations 
or changes of its capital or business structure;

(b)     merge or consolidate with other entities; or

(c)     dissolve, liquidate or sell, or transfer all or any part of its 
business or assets.

     3.06     Shareholder's Rights.  Optionee shall have no rights as a 
shareholder with respect to any shares Optionee is entitled to purchase 
under this Option until the date of the issuance of a stock certificate for 
such shares.  No adjustment shall be made for dividends (ordinary or 
extraordinary, whether in cash, securities or other property) or 
distributions or other rights for which the record date is prior to the date 
of issuance of such certificate, except as provided in this Agreement or in 
the Plan.


4.     Employment Conditions.

     4.01     Employment Status.  Optionee shall be considered to be in the 
employment of the Company as long as Optionee remains an Employee of the 
Company or its Affiliates.  The Board exclusively shall determine: 

(a)     whether or when there has been a termination of Optionee's employment 
or term of corporate office;

(b)     if there has been a failure to comply with Optionee's covenant not to 
compete obligations; and 

(c)     the cause of such termination, 

which determination shall be final.

                                    -4-
<PAGE> 

     4.02     Covenant Not to Compete.  Unless otherwise permitted in 
writing, Optionee, who is an Employee of the Company or its Affiliates, shall 
devote his entire time, energy and skill to the service of the Company or its 
Affiliates, subject to vacation, sick leave and other approved absences.  
Failure of Optionee to comply with the covenant not to compete obligations 
stated above within thirty (30) days of written notice of such failure shall 
cause, on the thirtieth (30th) day after such written notice, the 
cancellation of Optionee's right to purchase Option Stock (to the extent not 
previously exercised) without further action by the Company.  The 
restriction contained in this Paragraph 4.02 shall only apply to Employees, 
and not to officers or directors who are not Employees or consultants for 
the Company.

     4.03     Termination for Cause.  Unless otherwise agreed to by the 
Board, if Optionee's employment or his position as an officer or director of 
the Company or its Affiliates is terminated for cause, the right of Optionee 
to purchase Option Stock shall only be exercisable for a period of thirty 
(30) days after the date of such termination.


5.     Exercise.

     5.01     Exercise Amounts.  Subject to the earlier termination of the 
right to exercise this Option as provided under this Agreement, including 
Paragraphs 4.02 and 4.03 above, the Optionee shall be entitled to exercise 
the amounts of Option Stock, in whole or in part, as set forth in the 
Vesting Schedule on the Notice of Grant.

     5.02     Additional Adjustments.  Notwithstanding the terms of Paragraph 
5.01 of this Agreement, the Board in its sole and exclusive discretion may 
provide for conditions for the exercise of this Option and/or modify the 
Vesting Schedule set forth on the Notice of Grant; provided, however, the 
Board may only modify the conditions for the exercise of this Option and/or 
modify the Vesting Schedule to provide for a more restrictive Vesting 
Schedule with the consent of Optionee, if such modification alters or 
impairs any existing rights or obligations of Optionee under this Option.  

     5.03     Cumulative Exercise Rights.  If the Optionee does not exercise 
in any one year period the full number of shares to which he is then 
entitled to exercise, he may exercise those shares in any subsequent year 
prior to the Expiration Date of this Option as set forth on the Notice of 
Grant, or such later date subsequently approved by the Board or its 
delegates.

     5.04     Expiration of Exercise Rights.  Subject to the provisions of 
Paragraph 5.08, in no event shall this Option be exercisable after the 
Expiration Date or such later date subsequently approved by the Board or its 
delegates.

     5.05     Fractional Shares.  This Option shall not be exercisable with 
respect to any fractional shares of the Stock.

     5.06     Exercise Procedure.  This Option shall be exercised by the 
giving of written notice of exercise to the Company which specifies the 
number of shares of Stock to be purchased, accompanied by payment (in 
accordance with the terms of Paragraph 6(d) of the 

                                    -5-
<PAGE> 

Plan) of the aggregate Option Price for the shares of Stock being purchased, 
such payment to be made in any combination of:

              (a)     United States cash currency;

              (b)     a cashier's or certified check to the order of the 
                      Company;

              (c)     a personal check acceptable to the Company;

              (d)     to the extent permitted by the Board, shares of Stock 
                      (including previously owned Stock or Stock issuable in 
                      connection with the Option exercise), properly endorsed 
                      to the Company, whose Fair Market Value on the date of 
                      exercise equals the aggregate Option Price of the 
                      Option being exercised; or

              (e)     to the extent agreed to by the Board, the Optionee's 
                      entering into an agreement with the Company whereby a 
                      portion of the Optionee's Options are terminated and 
                      where the "built-in gain" on any Options which are 
                      terminated as part of such agreement equals the 
                      aggregate Option Price of the Option being exercised. 
                      "Built-in gain" means the excess of the aggregate Fair 
                      Market Value of any Stock otherwise issuable on 
                      exercise of a terminated Option, over the aggregate 
                      Option Price otherwise due the Company on such 
                      exercise.

The Board (in accordance with the terms of Paragraph 6(d) of the Plan) may 
provide such assistance to the Optionee to facilitate the exercise of this 
Option as it deems appropriate; provided, however, that the Board, as a 
prerequisite to providing such assistance, may require satisfaction of any 
rules or conditions it deems appropriate.  Shares of Stock used to pay the 
Option Price shall be valued at their Fair Market Value on the date of 
exercise.  The Optionee's notice of exercise shall also be accompanied by 
payment (in accordance with the terms of Paragraph 6(p) of the Plan) of the 
amount of federal and state income and employment taxes that the Company is 
required to collect from Optionee because of the exercise of the Option.

     5.07     Exercise During Life.  Subject to the provisions of Paragraphs 
4.02, 4.03 and 5.08, during Optionee's lifetime, this Option shall be 
exercisable only by Optionee either:

              (a)     while Optionee is employed by or serves as an officer 
                      or director of the Company or its Affiliates;

              (b)     within three (3) months after the date on which 
                      Optionee's employment or term of corporate office 
                      terminates for reasons other than "termination for 
                      cause" as provided in Paragraph 4.03 of this Agreement; 
                      or

              (c)     within one (1) year after the date on which the 
                      Optionee's employment or term of corporate office 
                      terminates due to a Disability;

                                    -6-
<PAGE> 

provided, however, that in no event shall the period of exercise be extended 
beyond the Expiration Date or such later date subsequently approved by the 
Board or its delegates.  Unless the Board or its delegates otherwise agree, 
if Optionee is entitled to purchase shares of Stock after the termination of 
Optionee's employment or termination of his corporate office, the number of 
shares of Stock Optionee may so purchase shall be limited to the number of 
shares of Stock Optionee was entitled to purchase as of such date of 
termination.

     5.08     Exercise After Death.  If Optionee dies while employed by or 
while serving as an officer or director of the Company or its Affiliates or 
within a period of three (3) months after the date such employment or term 
of corporate office terminates, but prior to the complete exercise of this 
Option, the Option may be exercised within one (1) year from the date of 
Optionee's death, but:

              (a)     only by a personal representative of Optionee, or by 
                      any person or persons who shall have acquired the 
                      Option directly from the Optionee by bequest or 
                      inheritance; and

              (b)     only as to the number of shares of Stock that Optionee 
                      was entitled to purchase under this Option on the date 
                      of Optionee's death.

     5.09     Consultancy to the Company After Termination of Employment or 
Term of Corporate Office.  If Optionee acts as a consultant for the Company 
or its Affiliates after the termination of his employment or term of 
corporate office, then Optionee shall not be deemed to have terminated his 
employment or term of corporate office for the Company or its Affiliates for 
the purposes of Paragraphs 5.07 and 5.08 of this Agreement until he ceases 
to be a consultant for the Company or its Affiliates, provided he does not 
violate any covenant not to compete obligations contained in his consulting 
agreement with the Company or its Affiliates.

     5.10     Exercise of Option Prior to Vesting.  The Board, in its sole 
and exclusive discretion, may permit the Optionee to exercise this Option 
prior to the date this Option is otherwise exercisable, provided the Stock 
issued on such exercise is subject to repurchase rights which expire pro rata 
as the Option would otherwise have become exercisable.

     5.11     Non-Sequential Exercise Permitted.  Subject to the exercise 
limitations set forth herein, this Option shall be exercisable 
notwithstanding the fact that there is an outstanding incentive stock option 
or non-statutory stock option for the purchase of Stock of the Company which 
was granted before this Option was granted, and no subsequently-granted 
incentive stock option shall fail to be exercisable solely because this 
Option remains outstanding.

     5.12     Legends.  Certificates for shares of Stock acquired upon 
exercise of this Option may contain such legends and transfer restrictions 
as the Company shall deem reasonably necessary or desirable to:  

              (a)     assure the satisfaction of any liability that the 
                      Company may or will have incurred for withholding of 
                      any federal and state income and employment taxes; 

                                    -7-
<PAGE> 

              (b)     facilitate compliance by the Company with any federal 
                      or state laws or regulations, including, without 
                      limitation, legends restricting transfer of 
                      the Stock until there has been compliance with federal 
                      and state securities laws; 

              (c)     assure notice of the Company's repurchase rights under 
                      Paragraph 5.10 of this Agreement; or 

              (d)     assure notice of such other restrictions as may be 
                      imposed on the Stock under the terms of this Agreement.


6.     Conflict Between Plan and Agreement.

     This Agreement, including the Option and Optionee's rights hereunder, 
is subject to and governed by the Plan.  Any conflict between the terms and 
provisions of this Agreement and the terms and provisions of the Plan shall 
be governed by the terms and provisions of the Plan.


7.     Investment Intent.

     This Option is granted on the condition that Optionee's purchase of 
Stock shall be for investment purposes for Optionee's own account and not 
with a view to resale or distribution.  The Company shall not, upon the 
exercise of this Option, be required to issue or deliver shares of Stock or 
certificates therefor if, in the opinion of counsel for the Company, such 
issuance or delivery would be in violation of, or would not comply with, any 
applicable state or federal securities law, regulation or rule.


8.     Notices.

     8.01     In Writing.  All notices, demands, requests, declarations, 
service of process, or other communications permitted or required under this 
Agreement or applicable law shall be in writing.

     8.02     Delivery.  All such communications may be served personally or 
may be sent by registered or certified mail, return receipt requested, 
postage prepaid and addressed to either Optionee or the Company at the 
addresses appearing at the top of the Notice of Grant, or at such other 
address as either party shall have communicated to the other pursuant to 
this Paragraph 8.02.  All such communications shall be deemed effectively 
delivered upon personal service or three (3) days after deposit in the 
United States Mail.


                                    -8-
<PAGE> 

9.     Miscellaneous.

     9.01     Successors and Assigns.  Except as otherwise provided in this 
Agreement, this Agreement shall inure to the benefit of only the Company, 
Optionee and their respective successors or assigns.

     9.02     Status.  Nothing contained in this Agreement shall be construed 
as giving Optionee any right to be retained as an Employee, officer or 
director of the Company.

     9.03     Severability.  If any provision or provisions of this Agreement 
are adjudged to be, for any reason, unenforceable, illegal or void, the 
remainder of the provisions shall remain in full force and effect.

     9.04     Integration.  This Agreement and the Notice of Grant to which 
this Agreement is an attachment constitute the entire understanding of the 
parties concerning this Option.  Except as otherwise provided, any changes, 
modifications, variations, or subordinations pertaining to this Agreement 
and the Notice of Grant are invalid, unless stated in writing and executed 
by the Company and Optionee.

     9.05     Governing Law.  This Agreement and the Option granted hereby 
shall be governed by the laws of the State of California.

     9.06     Attorneys' Fees.  If either party brings an action or seeks to 
enforce or interpret any of the terms or provisions of this Agreement, the 
prevailing party shall be entitled to recover its reasonable attorneys' fees 
and costs, in addition to any other remedy it may be awarded.

     9.07     Counterparts.  This Agreement may be executed in counterparts, 
and the counterparts shall constitute the whole instrument.

     9.08     Titles for Convenience; Gender; and Plurals.  Titles of 
articles and paragraph headings are for convenience only and shall not affect 
the construction or interpretation of this Agreement, or any portion thereof.  
Whenever required by the context hereof, the singular shall include the 
plural, and vice versa; the masculine gender shall include the feminine and 
neuter, and vice versa.


                                    -9-
<PAGE> 








                                                          EXHIBIT 10.69

                         AGOURON PHARMACEUTICALS, INC.
                          (a California Corporation)


                 1990 NON-STATUTORY STOCK OPTION AGREEMENT
                              FOR CONSULTANTS


     This Option Agreement is entered into between Agouron Pharmaceuticals, 
Inc., a California corporation and the Optionee whose name appears on the 
Notice of Grant of Stock Option to which this Agreement is an attachment.


1.     Recitals.

     1.01     The Board of Directors of the Company or its duly authorized 
delegates authorized the granting of this Option to Optionee who is a 
Consultant to the Company or its Affiliates pursuant to the Agouron 
Pharmaceuticals, Inc. 1990 Stock Option Plan.

     1.02     This Option Agreement is intended to constitute a non-statutory 
stock option, meaning an option which is not an "incentive stock option" 
within the meaning of Section 422 of Internal Revenue Code of 1986, as 
amended from time to time.


2.     Definitions.

     In addition to those words and phrases defined above and unless 
otherwise required by the context in which they appear, words and phrases 
having their initial letters capitalized shall have the following meanings:

     2.01     Act.  "Act" shall mean the Securities Exchange Act of 1934, as 
amended from time to time.

     2.02     Affiliate.  "Affiliate" shall mean any corporation defined as a 
"parent corporation" or a "subsidiary corporation" by Code Section 424(e) 
and (f), respectively.

     2.03     Agreement.  "Agreement" shall mean this 1990 Non-Statutory 
Stock Option Agreement for Consultants (including any schedules, attachments, 
documents incorporated by reference, or modifications agreed to in writing 
by the Company and Optionee) which sets forth the Optionee's and the 
Company's rights and obligations with respect to the Option granted Optionee 
by the Board or its duly authorized delegates as described on the Notice of 
Grant.

     2.04     Board.  "Board" shall mean the Board of Directors of the 
Company.


<PAGE>

     2.05     Code.  "Code" shall mean the Internal Revenue Code of 1986, as 
amended.

     2.06     Company.  "Company" shall mean Agouron Pharmaceuticals, Inc., a 
California corporation, and any successors or assigns.

     2.07     Consultant.  "Consultant" shall mean any person who is placed on 
the Corporation's Consultants List by the Board or its duly authorized delegates
and who agrees in writing to be included thereon.

     2.08     Consultant's Agreement.  "Consultant's Agreement" shall mean a 
consulting agreement between Optionee and the Company and/or its Affiliates.

     2.09     Date of Grant.  "Date of Grant" shall mean the Date of Grant set 
forth on the Notice of Grant.

     2.10     Disability.  "Disability" or "Disabled" shall mean the condition 
of being "disabled" within the meaning of Section 422(c)(6) of the Code or any 
successor provision. 

     2.11     Expiration Date.  "Expiration Date" shall mean the Expiration 
Date set forth on the Notice of Grant.

     2.12     Fair Market Value.  "Fair Market Value" of Stock on a given 
date shall mean an amount per share, as determined by the Board or its 
delegates by applying any reasonable valuation method determined without 
regard to any restriction other than a restriction which, by its terms, will 
never lapse.  Notwithstanding the preceding, if the Stock is traded upon an 
established stock exchange or exchanges or quoted on the over-the-counter 
market as reported by the National Association of Securities Dealers 
Automated Quotation Systems ("NASDAQ") National Market System, then the "Fair 
Market Value" of Stock on a given date per share shall be deemed to be the 
average of the highest and lowest selling price per share of the Stock on the 
principal stock exchange on which the Stock is then trading or on the over-
the-counter market as reported by NASDAQ National Market System on such 
date, or, if there was no trading of the Stock on that day, on the next 
preceding day on which there was such a trade; if the Stock is not traded 
upon an established stock exchange or quoted on the over-the-counter market 
as reported by NASDAQ National Market System but is quoted on the NASDAQ or 
a successor quotation system, the "Fair Market Value" of Stock on a given 
date shall be deemed to be the mean between the closing representative "bid" 
and "ask" prices per share of the Stock on such date as reported by the 
NASDAQ or such quotation system, or, if there shall have been no trading of 
the Stock on that day, on the next preceding day on which there was such 
trading.

     2.13     Notice of Grant of Stock Option.  "Notice of Grant of Stock 
Option" or "Notice of Grant" shall mean the Notice of Grant executed by the 
Company and the Optionee to which this Agreement is an attachment.

     2.14     Option.  "Option" shall mean the right of Optionee to purchase 
the number of shares of Stock set forth on the Notice of Grant in accordance 
with the terms and conditions of this Agreement.

                                      2
<PAGE>

     2.15     Optionee.  "Optionee" shall mean the person whose name is set 
forth on the Notice of Grant.

     2.16     Option Price.  "Option Price" shall mean the price per share of 
Stock to be paid by the Optionee upon exercise of the Option, which amount 
is set forth on the Notice of Grant.

     2.17     Option Stock.  "Option Stock" shall mean the total number of 
shares of Stock the Optionee shall be entitled to purchase pursuant to this 
Agreement, which number of shares is set forth on the Notice of Grant.

     2.18     Plan.  "Plan" shall mean the 1990 Agouron Pharmaceuticals, Inc. 
Stock Option Plan, as amended from time to time.

     2.19     Reporting Person.  "Reporting Person" shall mean an Optionee 
who is required to file statements relating to his or her beneficial 
ownership of Stock with the SEC pursuant to Section 16(a) of the Act.

     2.20     Rule 16b-3.  "Rule 16b-3" shall mean Rule 16b-3, as amended 
from time to time, promulgated by the SEC under the Act, and any successor 
thereto.

     2.21     SEC.  "SEC" shall mean the Securities and Exchange Commission.

     2.22     Stock.  "Stock" shall mean the no par common stock of the 
Company.

     2.23     Vesting.  "Vesting" shall mean the date(s) when all or a 
portion of the Option Stock becomes available for exercise.

     2.24     Vesting Schedule.  "Vesting Schedule" shall mean the Vesting 
Schedule set forth on the Notice of Grant which indicates on what dates all 
or a portion of the Option Stock becomes available for exercise.


3.     Option.

     3.01     Grant.  The Company hereby grants to Optionee an Option to 
purchase all or any part of the Option Stock on the terms and conditions set 
forth in this Agreement.  The Date of Grant shall be the Date of Grant set 
forth on the Notice of Grant.

     3.02     Purchase Price.  The purchase price per share of Stock to be 
paid upon the exercise of this Option shall be the Option Price set forth on 
the Notice of Grant.

     3.03     Restrictions on Transfer.  This Option may be transferred to a 
trust for the benefit of the Optionee or members of his immediate family.  
Upon any attempt to sell, assign, encumber or otherwise transfer this Option 
in violation of this Agreement, or upon the levy of 

                                      3
<PAGE>

any attachment or similar process upon this Option, this Option shall 
immediately become null and void.

     3.04     Modifications of Rights.  As set forth in Paragraph 6(l) of the 
Plan, the Board may modify (including, lowering the Option Price), extend or 
renew this Option (to the extent not previously exercised), or accept the 
surrender of this Option (to the extent not previously exercised) and 
authorize the granting of a new Stock option in substitution therefor; 
provided, however, that no modification of this Option shall, without the 
consent of the Optionee, alter or impair any existing rights or obligations 
of Optionee under this Option.

     3.05     Changes in Company's Equity Structure; Recapitalization of 
Company.  Upon the occurrence of the capital and/or recapitalization 
transactions described in Paragraph 6(j) of the Plan, this Option (to the 
extent not previously exercised) shall be adjusted or modified as provided 
in Paragraph 6(j) of the Plan.  Notwithstanding any provision of this 
Agreement, the Company reserves the right to:

              (a)     make or enter into any adjustments, reclassifications, 
                      reorganizations or changes of its capital or business 
                      structure;

              (b)     merge or consolidate with other entities; or

              (c)     dissolve, liquidate or sell, or transfer all or any 
                      part of its business or assets.

     3.06     Shareholder's Rights.  Optionee shall have no rights as a 
shareholder with respect to any shares Optionee is entitled to purchase 
under this Option until the date of the issuance of a stock certificate for 
such shares.  No adjustment shall be made for dividends (ordinary or 
extraordinary, whether in cash, securities or other property) or 
distributions or other rights for which the record date is prior to the date 
of issuance of such certificate, except as provided in this Agreement or in 
the Plan.


4.     Consultant Conditions.

     4.01     Consultant's Agreement.  Optionee shall be considered to be 
engaged by the Company and its Affiliates until the date of termination of 
Optionee's engagement under the terms of his Consultant's Agreement.  The 
Board, in accordance with the terms of Optionee's Consultant's Agreement 
shall determine: 

            (a)     whether or when there has been a termination of 
                    Optionee's engagement by the Company and its Affiliates;

            (b)     if there has been a failure to comply with Optionee's 
                    covenant not to compete obligations; and 

            (c)     the cause of such termination, 

                                      4
<PAGE>

which determination shall be final.

     4.02     Covenant Not to Compete.  Failure of Optionee to comply with 
the covenant not to compete obligations under the terms of his Consultant's 
Agreement within thirty (30) days of written notice of such failure shall 
cause, on the thirtieth (30th) day after such written notice, the 
cancellation of Optionee's right to purchase Option Stock (to the extent not 
previously exercised) without further action by the Company.  

     4.03     Termination for Cause.   If Optionee's engagement under the 
terms of his Consultant's Agreement is terminated for cause, the right of 
Optionee to purchase Option Stock shall only be exercisable for a period of 
thirty (30) days after the date of such termination.


5.     Exercise.

     5.01     Exercise Amounts.  Subject to the earlier termination of the 
right to exercise this Option as provided under this Agreement, including 
Paragraphs 4.02 and 4.03 above, the Optionee shall be entitled to exercise 
the amounts of Option Stock, in whole or in part, as set forth in the 
Vesting Schedule on the Notice of Grant.

     5.02     Additional Adjustments.  Notwithstanding the terms of Paragraph 
5.01 of this Agreement, the Board in its sole and exclusive discretion may 
provide for conditions for the exercise of this Option and/or modify the 
Vesting Schedule set forth on the Notice of Grant; provided, however, the 
Board may only modify the conditions for the exercise of this Option and/or 
modify the Vesting Schedule to provide for a more restrictive Vesting 
Schedule with the consent of Optionee, if such modification alters or 
impairs any existing rights or obligations of Optionee under this Option.  

     5.03     Cumulative Exercise Rights.  If the Optionee does not exercise 
in any one year period the full number of shares to which he is then 
entitled to exercise, he may exercise those shares in any subsequent year 
prior to the Expiration Date of this Option as set forth on the Notice of 
Grant, or such later date subsequently approved by the Board or its 
delegates.

     5.04     Expiration of Exercise Rights.  Subject to the provisions of 
Paragraph 5.08, in no event shall this Option be exercisable after the 
Expiration Date or such later date subsequently approved by the Board or its 
delegates.

     5.05     Fractional Shares.  This Option shall not be exercisable with 
respect to any fractional shares of the Stock.

     5.06     Exercise Procedure.  This Option shall be exercised by the 
giving of written notice of exercise to the Company which specifies the 
number of shares of Stock to be purchased, accompanied by payment (in 
accordance with the terms of Paragraph 6(d) of the Plan) of the aggregate 
Option Price for the shares of Stock being purchased, such payment to be 
made in any combination of:

                                      5
<PAGE>

             (a)     United States cash currency;

             (b)     a cashier's or certified check to the order of the 
                     Company;

             (c)     a personal check acceptable to the Company;

             (d)     to the extent permitted by the Board, shares of Stock 
                     (including previously owned Stock or Stock issuable in 
                     connection with the Option exercise), properly endorsed 
                     to the Company, whose Fair Market Value on the date of 
                     exercise equals the aggregate Option Price of the Option 
                     being exercised; or

             (e)     to the extent agreed to by the Board, the Optionee's 
                     entering into an agreement with the Company whereby a 
                     portion of the Optionee's Options are terminated and 
                     where the "built-in gain" on any Options which are 
                     terminated as part of such agreement equals the 
                     aggregate Option Price of the Option being exercised. 
                     "Built-in gain" means the excess of the aggregate Fair 
                     Market Value of any Stock otherwise issuable on exercise 
                     of a terminated Option, over the aggregate Option Price 
                     otherwise due the Company on such exercise.

The Board (in accordance with the terms of Paragraph 6(d) of the Plan) may 
provide such assistance to the Optionee to facilitate the exercise of this 
Option as it deems appropriate; provided, however, that the Board, as a 
prerequisite to providing such assistance, may require satisfaction of any 
rules or conditions it deems appropriate.  Shares of Stock used to pay the 
Option Price shall be valued at their Fair Market Value on the date of 
exercise.  The Optionee's notice of exercise shall also be accompanied by 
payment (in accordance with the terms of Paragraph 6(p) of the Plan) of the 
amount of federal and state income and employment taxes that the Company is 
required to collect from Optionee because of the exercise of the Option.

     5.07     Exercise During Life.  Subject to the provisions of Paragraphs 
4.02, 4.03 and 5.08, during Optionee's lifetime, this Option shall be 
exercisable only by Optionee either:

              (a)     while Optionee is engaged by the Company or its 
                      Affiliates under the terms of his Consultant's 
                      Agreement;

              (b)     within three (3) months after the date on which 
                      Optionee's engagement terminates for reasons other than 
                      "termination for cause" under the terms of his 
                      Consultant's Agreement and as provided in Paragraph 
                      4.03 of this Agreement; or

              (c)     within one (1) year after the date on which the 
                      Optionee's engagement terminates due to a Disability 
                      under the terms of his Consultant's Agreement;

                                      6
<PAGE>

provided, however, that in no event shall the period of exercise be extended 
beyond the Expiration Date or such later date subsequently approved by the 
Board or its delegates.  Unless the Board or its delegates otherwise agree, 
if Optionee is entitled to purchase shares of Stock after the termination of 
Optionee's engagement under his Consultant's Agreement, the number of shares 
of Stock Optionee may so purchase shall be limited to the number of shares of 
Stock Optionee was entitled to purchase as of such date of termination.

     5.08     Exercise After Death.  If Optionee dies while engaged by the 
Company or its Affiliates under the terms of his Consultant's Agreement or 
within a period of three (3) months after the date such engagement 
terminates, but prior to the complete exercise of this Option, the Option may 
be exercised within one (1) year from the date of Optionee's death, but:

             (a)     only by a personal representative of Optionee, or by any 
                     person or persons who shall have acquired the Option 
                     directly from the Optionee by bequest or inheritance; 
                     and

             (b)     only as to the number of shares of Stock that Optionee 
                     was entitled to purchase under this Option on the date 
                     of Optionee's death.

     5.09     Exercise of Option Prior to Vesting.  The Board, in its sole 
and exclusive discretion, may permit the Optionee to exercise this Option 
prior to the date this Option is otherwise exercisable, provided the Stock 
issued on such exercise is subject to repurchase rights which expire pro rata 
as the Option would otherwise have become exercisable.

     5.10     Non-Sequential Exercise Permitted.  Subject to the exercise 
limitations set forth herein, this Option shall be exercisable 
notwithstanding the fact that there is an outstanding incentive stock option 
or non-statutory stock option for the purchase of Stock of the Company which 
was granted before this Option was granted, and no subsequently-granted 
incentive stock option shall fail to be exercisable solely because this 
Option remains outstanding.

     5.11     Legends.  Certificates for shares of Stock acquired upon 
exercise of this Option may contain such legends and transfer restrictions as 
the Company shall deem reasonably necessary or desirable to:  

             (a)     assure the satisfaction of any liability that the 
                     Company may or will have incurred for withholding of any 
                     federal and state income and employment taxes; 

             (b)     facilitate compliance by the Company with any federal or 
                     state laws or regulations, including, without 
                     limitation, legends restricting transfer of the Stock 
                     until there has been compliance with federal and state 
                     securities laws; 

             (c)     assure notice of the Company's repurchase rights under 
                     Paragraph 5.09 of this Agreement; or 

                                      7
<PAGE>

             (d)     assure notice of such other restrictions as may be 
                     imposed on the Stock under the terms of this Agreement.


6.     Conflict Between Plan and Agreement.

     This Agreement, including the Option and Optionee's rights hereunder, 
is subject to and governed by the Plan.  Any conflict between the terms and 
provisions of this Agreement and the terms and provisions of the Plan shall 
be governed by the terms and provisions of the Plan.


7.     Investment Intent.

     This Option is granted on the condition that Optionee's purchase of 
Stock shall be for investment purposes for Optionee's own account and not 
with a view to resale or distribution.  The Company shall not, upon the 
exercise of this Option, be required to issue or deliver shares of Stock or 
certificates therefor if, in the opinion of counsel for the Company, such 
issuance or delivery would be in violation of, or would not comply with, any 
applicable state or federal securities law, regulation or rule.


8.     Notices.

     8.01     In Writing.  All notices, demands, requests, declarations, 
service of process, or other communications permitted or required under this 
Agreement or applicable law shall be in writing.

     8.02     Delivery.  All such communications may be served personally or 
may be sent by registered or certified mail, return receipt requested, 
postage prepaid and addressed to either Optionee or the Company at the 
addresses appearing at the top of the Notice of Grant, or at such other 
address as either party shall have communicated to the other pursuant to 
this Paragraph 8.02.  All such communications shall be deemed effectively 
delivered upon personal service or three (3) days after deposit in the 
United States Mail.


9.     Miscellaneous.

     9.01     Successors and Assigns.  Except as otherwise provided in this 
Agreement, this Agreement shall inure to the benefit of only the Company, 
Optionee and their respective successors or assigns.

     9.02     No Right to be a Consultant.  Nothing contained in this 
Agreement shall be construed as giving Optionee any right to be retained as a 
consultant for the Company.

     9.03     Severability.  If any provision or provisions of this Agreement 
are adjudged to be, for any reason, unenforceable, illegal or void, the 
remainder of the provisions shall remain in full force and effect.

                                      8
<PAGE>

     9.04     Integration.  This Agreement and the Notice of Grant to which 
this Agreement is an attachment constitute the entire understanding of the 
parties concerning this Option.  Except as otherwise provided, any changes, 
modifications, variations, or subordinations pertaining to this Agreement 
and the Notice of Grant are invalid, unless stated in writing and executed 
by the Company and Optionee.

     9.05     Governing Law.  This Agreement and the Option granted hereby 
shall be governed by the laws of the State of California.

     9.06     Attorneys' Fees.  If either party brings an action or seeks to 
enforce or interpret any of the terms or provisions of this Agreement, the 
prevailing party shall be entitled to recover its reasonable attorneys' fees 
and costs, in addition to any other remedy it may be awarded.

     9.07     Counterparts.  This Agreement may be executed in counterparts, 
and the counterparts shall constitute the whole instrument.

     9.08     Titles for Convenience; Gender; and Plurals.  Titles of 
articles and paragraph headings are for convenience only and shall not affect 
the construction or interpretation of this Agreement, or any portion thereof.  
Whenever required by the context hereof, the singular shall include the 
plural, and vice versa; the masculine gender shall include the feminine and 
neuter, and vice versa.

     9.09     Consultants List.  Consultant's execution of this Agreement 
indicates his written agreement to be placed on the Company's Consultants 
List.



                                      9
<PAGE>




                                                          Exhibit 10.74

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED FOR PORTIONS OF THIS AGREEMENT 
PURSUANT TO AN APPLICATION DATED JANUARY 27, 1997, AS SEPARATELY FILED WITH 
THE SECURITIES AND EXCHANGE COMMISSION.  CONFIDENTIAL PORTIONS ARE INDICATED 
WITH AN ASTERISK ("*"), EXCEPTING THOSE ASTERISKS CONTAINED IN SCIENTIFIC 
FORMULAS CONTAINED IN SECTION 2(A) OF EXHIBIT A.

                                LETTER OF INTENT

     THIS LETTER OF INTENT is made on the 17th day of January 1997, by and 
between Agouron Pharmaceuticals, Inc., a corporation duly organized and 
existing under the laws of the state of California, having a principal place 
of business at 10350 North Torrey Pines Road, La Jolla, California, United 
States of America (hereinafter called "Agouron"), Japan Tobacco Inc., a 
corporation duly organized and existing under the laws of Japan, having its 
principal place of business at JT Building, 2-1, Toranomon 2-chome, Minato-
ku, Tokyo, Japan (hereinafter called "JT"), and F. Hoffmann-La Roche Ltd., a 
corporation duly organized and existing under the laws of Switzerland, 
having its principal place of business at CH-4002-Basel, Switzerland 
(hereinafter called "Roche").  Agouron, JT and Roche are sometimes 
hereinafter referred to as a party (collectively "parties") to this 
Agreement.

                                 Background

     In December 1994, Agouron and JT entered into a Development and 
License Agreement ("D&L Agreement") under which they have collaborated in 
the development and commercialization of the chemical compound known as 
"nelfinavir mesylate" to treat and prevent Human Immunodeficiency Virus 
infections.  Agouron, JT and Roche now agree to enter into a license 
agreement under which Roche will be licensed to sell nelfinavir mesylate in 
certain countries of the world.  This Letter of Intent ("LOI") which shall 
be binding on the parties sets forth the basic license terms upon which the 
parties have agreed.  The full terms of the license will be set forth in a 
definitive agreement to be prepared as described below.

     NOW THEREFORE, the parties agree as follows:

     1.     Terms.  The parties hereby enter into this Letter of Intent to 
confirm their entering into a license agreement on terms substantially in 
accordance with those contained in Exhibit A attached hereto.  The parties 
acknowledge that Exhibit A only states the basic terms of the understanding 
between the parties and is subject to the further negotiation and 
preparation of an agreement containing the full terms of the license between 
the parties ("Definitive Agreement").  Each party agrees to act in good 
faith in an effort to negotiate, execute and deliver the Definitive 
Agreement on or before *                .

     2.     Disclosure.  The parties shall jointly prepare and release a 
statement about the existence of this Letter of Intent and of the license 
between Agouron, JT and Roche.  Except as agreed to by the parties, Agouron, 
JT and Roche shall not release any further information to any third party 
who is not under an obligation of confidentiality with respect thereto about 
any of the terms of this Letter of Intent or of the license without the 
prior written consent of the other parties, which consent shall not 
unreasonably be withheld.  This prohibition includes, but is not limited to, 
press releases, educational and scientific conferences, promotional 
materials and discussions with the media.  If a party determines that it is 
required by law to release information to any third party regarding the 
terms of this Letter of Intent or the subject matter of the license, it 
shall notify the other parties of this fact prior to releasing the 
information.  The notice to the other parties shall include the text of the 
information proposed for release.  The other parties

<PAGE>

shall have the right to confer with the notifying party regarding the 
necessity for the disclosure and the text of the information proposed for 
release.

     3.     Miscellaneous.  This Letter of Intent contains the entire 
agreement between the parties as to the matters set forth herein and shall 
be construed in accordance with the laws of the State of California, United 
States of America.  Exhibit A describes the parties' understanding with 
respect to the development and sale of nelfinavir mesylate by Roche in 
certain countries of the world.  This Letter of Intent, including Exhibit A, 
shall not be amended, supplemented or otherwise modified, except by an 
instrument in writing signed by duly authorized officers of all of the 
parties.  Roche shall bear all of the expenses incurred by it in connection 
with the negotiation and preparation of this Letter of Intent and the 
Definitive Agreement.  Agouron and JT shall bear all of the expenses 
incurred by them in connection with the negotiation and preparation of this 
Letter of Intent and the Definitive Agreement.  Notwithstanding the 
preceding, the use and disclosure of confidential and proprietary 
information disclosed to Roche for the purpose of determining Roche's 
interest in entering into (and for the subsequent negotiation and 
performance of) a license agreement for Viracept for certain countries of 
the world shall be governed by the terms of the Confidentiality Agreement 
between the parties with an effective date of January 7, 1997.

     IN WITNESS WHEREOF, the parties hereto have executed this Letter of 
Intent by their respective officers thereunto duly authorized, the day and 
year hereinabove written.  This Letter of Intent may be executed in 
counterparts and all of such counterparts taken together shall be deemed to 
constitute one and the same instrument.

AGOURON PHARMACEUTICALS, INC.      JAPAN TOBACCO INC.

By:     /s/ Kent Snyder            By:     /s/ Masamichi Nishimoto          
Name:  Kent Snyder                 Name:   Masamichi Nishimoto               
Title: Vice President              Title:  Executive Vice President          

By:    /s/ Gary Friedman           By:     /s/ Masakazu Kakei               
Name:  Gary Friedman               Name:   Masakazu Kakei               
Title: Vice President              Title:  Managing Director               

F. HOFFMANN-LA ROCHE LTD     

By:    /s/ Werner Henrich                    
Name:  Werner Henrich                    
Title: Director                         

By:    /s/ Dr. Bruno Maier                    
Name:  Dr. Bruno Maier                    
Title: Deputy Director                    

<PAGE>

                                  Exhibit A
 
 
1.     JT and Agouron, individually and directly, under terms and conditions 
specified below, hereby grant Roche the exclusive right, even as to 
Agouron and JT, to sell the Product in the Field in the Licensed 
Territory.
 
2.     Definitions:  Except as otherwise set forth herein, items containing 
an initial capitalized letter shall have the meaning stated in the 
Letter of Intent ("LOI") and/or this Exhibit A.
 
      (a) "Product" means nelfinavir mesylate, however formulated, whose 
          chemical name is as follows:
 
           [3S-(3R*, 4aR*, 8aR*, 2'S*, 3'S*)]-2-[2'-hydroxy-3'-
           phenylthiomethyl-4'-aza-5'-oxo-5'-(2''-methyl-3''-
           hydroxyphenyl)pentyl]-decahydroisoquinoline-3-N-t-butyl 
           carboxamide methanesulfonic acid salt,
 
           and whose chemical structure is as follows:
 
<DIAGRAM>
  
 
     (b) "Licensed Territory" means all countries of the world, except 
          for the United States (and its territories, possessions and 
          protectorates, and the District of Columbia), Canada, Mexico, 
          Japan, Taiwan, South Korea, North Korea, and all the countries 
          of Asia listed on Schedule 1 attached hereto.
 
     (c) "Field" means the treatment and prevention of Human 
         Immunodeficiency Virus ("HIV") infections.
 
     (d) "Affiliate" means any person, organization or entity which is, 
         directly or indirectly, controlling, controlled by, or under 
         common control with Roche, Agouron or JT, as the case may be.  
         The term "control" (including, with correlative meaning, the 
         terms "controlled by" and "under common control with"), as used 
         with respect to any person or entity, means the possession, 
         directly or indirectly, of the power to direct or cause the 
         direction of the management and 
 
                                     A-1
 <PAGE>
 
        policies of such person, organization or entity, whether through the 
        ownership of voting securities, or by contract, or court order, or 
        otherwise.  The ownership of voting securities of a person, 
        organization or entity shall not, in and of itself, constitute 
        "control" for purposes of this definition, unless said ownership is 
        of a majority of the outstanding securities entitled to vote of such 
        person, organization or entity.  For purposes of this Agreement, 
        Genentech, Inc. shall be considered to be an Affiliate of Roche.
 
     (e) "Major European Country" means the *                                   
 
 
     (f) "MAA" means Marketing Authorization Application.
 
     (g) "EMEA" means the European Agency for the Evaluation of Medicinal 
         Products.
 
     (h) "D&L Agreement" means the December 1, 1994 Development and 
         License Agreement between Agouron and JT.
 
3.     The term of this license will extend on a country-by-country basis 
from the effective date of the signing of the LOI to which this 
Exhibit A is an attachment, until the later of:  (i) the last to 
expire of any patents covering the Product in a country; or (ii) *   years 
after the date of the initial commercial launch of the Product in such 
country.
 
4.     With the consent of JT and Agouron, whose consent shall not be 
unreasonably withheld, Roche shall have the right to sublicense its 
rights in the Product in one or more countries of the Licensed 
Territory.
 
5.     Subject to the provisions of the D&L Agreement, Agouron may *         

be agreed upon by the parties after discussions between Roche and 
Agouron.  Subject to the provisions of the D&L Agreement, JT may *            
 
                                                         to 
be agreed upon by the parties after discussions between Roche and JT.  
The terms of the *     

                     modified to reflect the *                      
 

 
6.     Until *               except for the countries of *                  
 
            in countries where either JT or Agouron control the 
exclusive rights to the Product, *                                      
 

                            On or before *            
               the parties agree to further discuss the *                       
 


 
                                     A-2
 <PAGE>
 
                           For purposes of this paragraph, JT and 
Agouron shall not be considered independent third parties.
 
7.     Except as otherwise agreed to by the parties, Agouron and JT will be 
responsible for
completing in a reasonable manner and funding the studies  *                   
 
studies include the core development program studies designed to 
achieve registration of the Product in the Field in the major 
countries of the Licensed Territory.  The parties acknowledge that 
Agouron and JT despite reasonable diligence may be unable to *        





 
8.     In collaboration with Roche, Agouron will be responsible for *          
 

                                              and will have 
the primary responsibility for *                                               
 


             Roche and its Affiliates will provide assistance, as 
necessary, to *             





                                                    Roche 
will have the primary responsibility for the *                                  
  
                                               Roche will be 
responsible for *                                                        
 

 
9.     Alterations to the *           which are required for *                  
 
                                         will be the 
responsibility of *                                Except as 
otherwise agreed to by the parties, Roche will be responsible for *         
 




 
10.     Roche will be responsible for *                                    
(other than those *               ) which involve the *                       
 
               (including *                                        
 
                                   ). Roche will be responsible 
for the 
 
                                     A-3
 <PAGE>
 
*

 
11.    A party conducting a study involving the Product will assist the other 
parties in the incorporation of the data from such study into their  
dossiers, if necessary.  *               





 
12.    Roche will be responsible for the cost and implementation (possibly in 
cooperation with a previously-contracted contract research 
organization) of an expanded access program in Europe and Australia 
which will be consistent in scope with the expanded access program 
implemented by Agouron in North America. 
 
13.    Roche shall use reasonable diligence in the development and 
registration of the Product in the Field in the countries of the 
Licensed Territory.  Reasonable diligence shall mean at least the 
comparable standard of effort used by Roche in *                       
 

                                               If, after *   
days written notice of the failure by Roche to use reasonable 
diligence in the development and registration of the Product in the 
Field in a country located in the Licensed Territory Roche fails to 
fulfill its obligations under this paragraph, such failure shall be 
deemed to be an election pursuant to *                                        
 

 
14.    Roche will purchase the Product from JT or Agouron directly as 
determined by JT and Agouron,*


 
15.    Roche will make the following license issue fee payments to Agouron 
and JT directly.
 
 
 On January 24, 1997
      To Agouron                            USD 9 million
      To JT                                 USD 9 million
 
 Within thirty (30) days of first regulatory approval
 in a Major European Country or upon marketing 
 authorization from the European Commission
      To Agouron                           USD 11 million
      To JT                                USD 11 million
                                           --------------
                    TOTAL                  USD 40 million 
 
 
                                     A-4
 <PAGE>
 
16.    * 
                                    will be consistent with the 
*           
                                         will modify the *           
 
          only to the extent required to respond to *          
           and implement *                                                   
 

                                                         As 
they deem appropriate, Agouron, JT and their licensees will *                 
 


 
17.    It is the intent of the parties that a single trademark be identified 
and developed for use in connection with marketing the Product in the 
Field wherever possible throughout the Territory.  The parties 
acknowledge their intention to  use the VIRACEPT (R) trademark in 
connection with the marketing of the Product in the Field wherever 
possible.  Unless otherwise agreed and as permitted by law, Roche will  
sell the Product under the VIRACEPT brand name in all countries of the 
Licensed Territory.  The parties also acknowledge their intention to  
use, if appropriate, the same trade dress in connection with the 
marketing of the Product in the Field wherever possible.  In  
countries where Roche is  exclusively marketing the Product, unless 
prohibited by law or regulation, the labeling for the Product shall 
state that the Product is licensed from Agouron and JT.
 
18.    *












 
19.     *                                   Roche using diligent 
marketing efforts, agrees to provide sales and other promotional 
support for the Product in each country in the Licensed Territory 
which is equivalent to or greater than that which Roche, its 
Affiliates and/or sublicenses are providing *                              
After the *            Roche will provide a reasonable level of 
sales and other promotional support for the Product in each country in 
the Licensed Territory which, when measured as a percentage of 
adjusted gross product sales in such country, is equivalent to or 
greater than that which Roche, its Affiliates and/or sublicenses are 
providing for *                        

shall be attributed to          *.  If, after *           written 
notice of the failure by Roche to 
 
                                     A-5
 <PAGE>
 
provide the agreed upon level of 
sales and other promotional support for the Product in a country 
located in the Licensed Territory Roche fails to fulfill its 
obligation under this Paragraph, Agouron and JT shall have the right, 
*                             







 
20.     Roche shall keep Agouron and JT informed of its progress in the 
development and registration of the Product.  This shall include, at 
least *                the regular meetings of the parties and such 
written progress reports as are agreed to by the parties summarizing 
Roche's activities during each reporting period and Roche's planned 
activities for the succeeding period.  Agouron and JT shall keep Roche 
informed of their development and registration activities to the 
extent that such development and registration activities are relevant 
to the development and registration of the Product by Roche in the 
Licensed Territory.  Each of the parties will *                             
 
                               each representative shall report 
to his/her management on the matters discussed at each of the meetings 
of the parties.  Each party, prior to the implementation of *     
                     will provide the other parties with a copy of 
the *                     and an opportunity in a timely manner to 
comment on the *                                         


                                Roche agrees to use its diligent 
efforts in responding in a timely manner, but not more than *     
      to requests from Agouron or JT for information *
 
21.     Roche shall keep Agouron and JT informed of *                          
 
                   This shall include, at least *                    
the regular meetings of the parties and such written progress reports 
as are agreed to by the parties summarizing Roche's activities during 
each reporting period and Roche's planned activities for the Product 
for the succeeding period.  Each of the parties will *                     
 
                               each representative shall report 
to his management on the matters discussed at each of the meetings of 
the parties.  The representatives of the parties at the meeting will 
review and discuss *                      


                                                        Each 
party agrees to inform the other parties, *                                    
 

 
                                     A-6
 <PAGE>
 
 
22.     Agouron, JT and Roche each acknowledge the interests of the other 
parties *                    


            The parties also recognize their mutual interests in 
obtaining *                  
                      Consequently, a party, its employees or 
consultants 
*




                     Furthermore, in acknowledgment that certain *         
 

                               the parties agree that each party 
shall 
*







                           After giving reasonable consideration 
to the suggestions of the objecting party, the party wishing to *               
 

 
23.     Roche will pay JT and Agouron directly, a royalty based on the net 
sales of the Product by Roche, its Affiliates and sublicenses, 
consolidated into CHF, in amounts which equal the greater of:  (i) the 
royalty amounts calculated according to Schedule 1 below (Product 
only); or (ii) the royalty amounts calculated according to Schedule 2 
below (Product and any formulations of INVIRASE which Roche markets 
with royalties being calculated separately for the consolidated annual 
net sales of the Product and INVIRASE).  Schedule 2 shall not apply to 
net sales in a country until the Product is approved and available for 
sale in such country.  The following royalties shall be divided 
equally between JT and Agouron.
 
 Schedule 1
 
 Royalty Rate 
 Per Consolidated                     Consolidated Annual Net Sales Level 
 Annual Net Sales Level               of the Product in Licensed Territory
 ----------------------             --------------------------------------
      *                              <= CHF   *                
      *                               > CHF   *             / <= CHF    * 
      *                               > CHF   *                 
 
 
                                     A-7
 <PAGE>
 
 Schedule 2
 
                                    Consolidated Annual Net Sales Level for
                                    the Product and INVIRASE in the Licensed
                                    Territory (With Royalties Being 
 Royalty Rate                       Calculated Separately for the 
 Per Consolidated                   Consolidated Annual Net Sales of the
 Annual Net Sales Level             Product and INVIRASE) 
 ----------------------             --------------------------------------
      *                             <= CHF   *                
      *                             > CHF   *             / <= CHF    * 
      *                             > CHF   *                 
 
24.    If either:  (i) regulatory approval for the Product is not obtained in 
a Major European Country prior to *           or (ii) marketing 
authorization for the Product is not obtained from the European 
Commission prior to *                the royalty rate for Schedule 2 
will be adjusted as follows:
 
 Schedule 2
 
                                    Consolidated Annual Net Sales Level for
                                    the Product and INVIRASE in the 
                                    Licensed Territory (With Royalties
 Royalty Rate                       Being Calculated Separately for the
 Per Consolidated                   Consolidated Annual Net Sales of the
 Annual Net Sales Level             Product and INVIRASE)                  
 ----------------------             --------------------------------------
      *                             <= CHF   *                
      *                             > CHF   *             / <= CHF    * 
      *                             > CHF   *                 
 
25.    If either:  (i) regulatory approval for the Product is not obtained in 
a Major European Country prior to *           or (ii) marketing 
authorization for the Product is not obtained from the European 
Commission prior to *                Schedule 2 will not apply and 
Roche will be obligated to pay JT and Agouron directly, royalties 
according to Schedule 1 only.
 
26.     Roche agrees not to market any other HIV protease inhibitors in the 
Licensed Territory during the term of the agreement, unless sales for 
such product(s) are included in the consolidated net sales calculation 
according to Schedule 2.
 
27.     *      despite reasonable efforts to * 
 


                                                   provided, 
however, that in no case will *                                     

                The parties acknowledge that the *                 



                that the provisions of this paragraph do not apply 
to *           

                                     A-8
<PAGE>

                                                 The parties 
specifically acknowledge that *                                           
 


                                   Notwithstanding the 
preceding, *      


which are then being commercially used in the manufacture of the 
Product, the parties will * 

 
28.     In any country where the amount of third party unlicensed sales of 
drug products containing nelfinavir mesylate for a quarterly period 
exceed *     of the total sales of all drug products containing 
nelfinavir mesylate in such country for such quarterly period, 
royalties due on the net sales of the Product in such country for such 
quarterly period will be *  
 
29.     Roche will purchase the Product from Agouron or JT directly, for sale 
in the Licensed Territory at a price which *      
  


 
30.     *                                                        and 
if Agouron or JT, independently or jointly, *      
 




 
31.     Roche will assist Agouron and JT in the  identification of low-cost 
manufacturing sources for the Product.  Roche will also provide 
without charge, to the extent available,  technical and manufacturing 
assistance and use of its technology and proprietary information to 
Agouron and JT in an effort to decrease the production costs of the 
Product.  Agouron and JT agree to discuss in good faith with Roche an 
arrangement under which Roche could  be the contract manufacturer of 
the Product to be used in the Licensed Territory, including the 
prerequisite requirement that *                                           
 


Notwithstanding the preceding, Agouron and JT shall be entitled to *
             
 

      including the right to continue their *    
 

 
32.      *





                                     A-9
<PAGE>

      Subject to the provisions of the D&L Agreement, in the event 
that * 

                            Agouron and JT, their Affiliates and 
sublicensees shall be free, without any further action by Agouron, JT 
or Roche and without any further obligation to Roche and its 
Affiliates, to *                                               


                               provided that Agouron and JT 
shall not 
*

           For purposes of this paragraph, Roche's *
 


                                In the event of *
 
                                                     pursuant 
to the terms of this paragraph:  (i) the *
 
                    (ii) Agouron and JT, their Affiliates and 
sublicensees shall 
*

           (iii) Roche shall *                                  
                                                 and 
(iv) Roche shall 
*
                                                   Roche 
shall be responsible for *                                               
 



 
33.     Roche may elect to *                                               
           In the event that Roche elects to *                           
 
            , subject to the provisions of the D&L Agreement:  (i) 
Agouron and JT shall 
*
                          (ii) Agouron and JT will *                     
 
                                        (iii) Roche shall *                    
 

                and (iv) Roche shall *                                       
 

 
34. This Agreement shall be assignable by Agouron and JT, but shall not be 
assignable by Roche, except to an Affiliate, without the prior written 
consent of Agouron and JT, which consent may be withheld at the sole 
discretion of Agouron and JT.  Any such assignment without the prior 
written consent of Agouron and JT shall be void.  If this Agreement is 
assigned to an Affiliate, Roche shall still be responsible for all of 
its obligations specified in this Agreement.  Notwithstanding the 
preceding, in the event of:  (i) a sale or transfer of all or 
substantially all of Roche's assets; or (ii) the merger or 

                                     A-10
<PAGE>

consolidation of Roche with another company, this Agreement shall be 
assignable to the transferee or successor company. 
 
35.     *




                                     A-11
<PAGE>



 
   
                          SCHEDULE 1 TO EXHIBIT A
                              ASIAN COUNTRIES


*
*
*
*
*
*
*
*
*
*
*
*
*
*

Licenses in the above-listed countries shall be subject to compliance by 
Roche with the United States laws and regulations governing exports and re-
exports of the Product and any technology developed or disclosed as a result 
of this Agreement.

                                       S1-1
<PAGE>

                            SCHEDULE 2 TO EXHIBIT A
                       NELFINAVIR MESYLATE *                        


Protocol      Title
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *


                                       S2-1
<PAGE>

Protocol      Title
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *

                                       S2-2
<PAGE>

Protocol      Title
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *
  *           *

                                       S2-3
<PAGE>



<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE BALANCE
SHEET AND THE STATEMENT OF OPERATIONS AND IS QUALIFIED IN ITS ENTIRETY BY
REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          JUN-30-1997
<PERIOD-END>                               DEC-31-1996
<CASH>                                          16,827
<SECURITIES>                                    92,071
<RECEIVABLES>                                    6,151
<ALLOWANCES>                                         0
<INVENTORY>                                     21,400
<CURRENT-ASSETS>                               137,819
<PP&E>                                          24,646
<DEPRECIATION>                                  15,241
<TOTAL-ASSETS>                                 147,224
<CURRENT-LIABILITIES>                           18,279
<BONDS>                                              0
                                0
                                          0
<COMMON>                                       237,369
<OTHER-SE>                                   (110,048)
<TOTAL-LIABILITY-AND-EQUITY>                   147,224
<SALES>                                              0
<TOTAL-REVENUES>                                32,623
<CGS>                                                0
<TOTAL-COSTS>                                   45,378
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                  80
<INCOME-PRETAX>                               (27,003)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                           (27,003)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                  (27,003)
<EPS-PRIMARY>                                   (2.07)
<EPS-DILUTED>                                   (2.07)
        

</TABLE>

<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
RESTATED FINANCIAL STATEMENT

THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE BALANCE
SHEET AND THE STATEMENT OF OPERATIONS AND IS QUALIFIED IN INS ENTIRETY BY
REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<RESTATED> 
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   12-MOS
<FISCAL-YEAR-END>                          JUN-30-1996
<PERIOD-END>                               JUN-30-1996
<CASH>                                          16,451
<SECURITIES>                                    74,424
<RECEIVABLES>                                      613
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                93,288
<PP&E>                                          20,646
<DEPRECIATION>                                  13,710
<TOTAL-ASSETS>                                 100,224
<CURRENT-LIABILITIES>                           22,907
<BONDS>                                              0
                                0
                                          0
<COMMON>                                       158,628
<OTHER-SE>                                    (83,045)
<TOTAL-LIABILITY-AND-EQUITY>                   100,224
<SALES>                                              0
<TOTAL-REVENUES>                                55,955
<CGS>                                                0
<TOTAL-COSTS>                                   51,099
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 228
<INCOME-PRETAX>                               (19,523)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                           (19,523)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                  (19,523)
<EPS-PRIMARY>                                   (1.98)
<EPS-DILUTED>                                   (1.98)
        

</TABLE>

<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
RESTATED FINANCIAL DATA SCHEDULE

THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION FROM THE BALANCE SHEET AND
THE STATEMENT OF OPERATIONS AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO
SUCH STATEMENTS.
</LEGEND>
<RESTATED> 
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          JUN-30-1997
<PERIOD-END>                               SEP-30-1996
<CASH>                                          17,355
<SECURITIES>                                   126,797
<RECEIVABLES>                                    6,810
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                               158,296
<PP&E>                                          21,943
<DEPRECIATION>                                  14,488
<TOTAL-ASSETS>                                 165,751
<CURRENT-LIABILITIES>                           25,229
<BONDS>                                              0
                                0
                                          0
<COMMON>                                       236,306
<OTHER-SE>                                    (97,492)
<TOTAL-LIABILITY-AND-EQUITY>                   165,751
<SALES>                                              0
<TOTAL-REVENUES>                                17,514
<CGS>                                                0
<TOTAL-COSTS>                                   25,314
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                  64
<INCOME-PRETAX>                               (14,447)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                           (14,447)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                  (14,447)
<EPS-PRIMARY>                                   (1.15)
<EPS-DILUTED>                                   (1.15)
        

</TABLE>


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