AGOURON PHARMACEUTICALS INC
S-3/A, 1998-06-17
PHARMACEUTICAL PREPARATIONS
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     As filed with the Securities and Exchange Commission on June 17, 1998
                                                Registration No. 333-29863


===============================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             -----------------------


                                 AMENDMENT NO. 2
                                       TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                          Agouron Pharmaceuticals, Inc.
             (Exact name of registrant as specified in its charter)

                   California                                    33-0061928
          (State or other jurisdiction                        (I.R.S. Employer
       of incorporation or organization)                    Identification No.)
                              -----------------------

            10350 North Torrey Pines Road, La Jolla, California 92037
                                                         (619) 622-8000
     (Address, including zip code, and telephone number, including area code, of
registrant's principal executive offices)

                                  Peter Johnson
                      President and Chief Executive Officer
                          AGOURON PHARMACEUTICALS, INC.
            10350 North Torrey Pines Road, La Jolla, California 92037
                                                         (619) 622-8000
           (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                             -----------------------

     Approximate date of commencement of proposed sale to the public:  From time
to time after the effective date of this Registration Statement as determined by
the Selling Stockholders.
     If the only  securities  being  registered  on this Form are being  offered
pursuant to dividend or interest  reinvestment plans, please check the following
box.
     If any of the securities being registered on this Form are to be offered on
a delayed or continuous  basis  pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box.
     If this Form is filed to  register  additional  securities  for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list  the  Securities  Act  registration  statement  number  of the  earlier
effective registration statement for the same offering.
     If this Form is a  post-effective  amendment  filed pursuant to Rule 462(c)
under the  Securities  Act,  check the following box and list the Securities Act
registration  statement number of the earlier effective  registration  statement
for the same offering.
     If delivery of the  Prospectus is expected to be made pursuant to Rule 434,
please check the following box.
                             -----------------------



===============================================================================


<PAGE>





                      WITHDRAWAL OF REGISTRATION STATEMENT.

         Pursuant to the terms of the Registration  Statement,  and as set forth
in the Prospectus  which is a part thereof,  the  Registrant  agreed to keep the
Registration Statement effective until the earlier to occur of the resale of all
of the Shares described in the Prospectus or May 23, 1998. Accordingly,  by this
Amendment 2 to the Registration  Statement,  the Registrant hereby withdraws the
Registration Statement.



                                   SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this amendment to
registration statement to be signed on its behalf by the undersigned,  thereunto
duly authorized,  in the City of San Diego, State of California, on the 17th day
of June, 1998.

                          AGOURON PHARMACEUTICALS, INC.

             By:      /s/Gary E.Friedman
                         Gary E.Friedman
                         Corporate Vice President, General Counsel and Secretary




<PAGE>




     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has been signed below by the  following  persons in the
capacities and on the dates indicated.
<TABLE>
<CAPTION>

            Signature                                       Title                                  Date
<S>                                                 <C>                                       <C>    

     * Peter Johnson                                 President, Chief Executive                June 17, 1998
- - ------------------------------------------
Peter Johnson                                        Officer and Director

     * Steven S. Cowell                              Corporate Vice President, Finance         June 17, 1998
- - ------------------------------------------
Steven S. Cowell                                     and Chief Financial Officer

     /s/ Gary  E. Friedman                           Corporate Vice President, General         June 17, 1998
- - ------------------------------------------
Gary E. Friedman                                     Counsel, Secretary and Director

     * John N. Abelson                               Director                                  June 17, 1998
- - ------------------------------------------
John N. Abelson

     * Patricia M. Cloherty                          Director                                  June 17, 1998
- - ------------------------------------------
Patricia M. Cloherty

     * A.E. Cohen                                    Director                                  June 17, 1998
A.E. Cohen

     * Michael E. Herman                             Director                                  June 17, 1998
- - ------------------------------------------
Michael E. Herman

     * Irving S. Johnson                             Director                                  June 17, 1998
- - ------------------------------------------
Irving S. Johnson

     * Antonie T. Knoppers                           Director                                  June 17, 1998
- - ------------------------------------------
Antonie T. Knoppers

     * Melvin I. Simon                               Director                                  June 17, 1998
- - ------------------------------------------
Melvin I. Simon


*By:   /s/ Gary E. Friedman                                                                    June 17, 1998
           Gary E. Friedman
</TABLE>


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