CRITICARE SYSTEMS INC /DE/
SC 13D, 2000-10-27
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                                (Amendment No. )*

                             Criticare Systems, Inc.
                                (Name of Issuer)

                                  Common Stock
                         (Title of Class of Securities)

                                    226901106
                                 (CUSIP Number)


                                Jeffrey T. Barnes
                           Oxford Bioscience Partners
                           31 St. James Ave., Ste. 905
                                Boston, MA 02116
           (Name, Address and Telephone Number of Person Authorized to
                      Receive Notices and Communications)

                                October 17, 2000
             (Date of Event which Requires Filing of this Statement)




If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss.240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check the
following box. [ ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule,  including all  exhibits.  Seess.240.13d-7(b)  for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    2 of 19

     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          Oxford  Bioscience Partners III LP; Tax Id No. 04-3480313


     2.   Check The  Appropriate  Box If A Member Of A Group (See  Instructions)
          (a) [ ]
          (b) [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e) [ ]


     6.   Citizenship Or Place Of Organization

          Delaware

                  7.  Sole Voting Power

Number Of         0 shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              1,547,529 shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 shares

                  10.  Shared Dispositive Power

                  1,547,529 shares

     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          1,547,529 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [X]

     13.  Percent Of Class Represented By Amount In Row (11)

          14.4%

     14.  Type Of Reporting Person (See Instructions)

          PN


<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    3 of 19


     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          Oxford Bioscience Partners (Bermuda ) III Limited Partnership;  Tax Id
          No 98-0212888


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e) [ ]


     6.   Citizenship Or Place Of Organization

          Bermuda

                  7.  Sole Voting Power

Number Of         0 Shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              220,555 Shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 Shares

                  10.  Shared Dispositive Power

                  220,555 Shares

     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          220,555 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [X]

     13.  Percent Of Class Represented By Amount In Row (11)

          2.0%

     14.  Type Of Reporting Person (See Instructions)

          PN

<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    4 of 19




     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          mRNA Fund L.P.; Tax Id No. 04-3525525


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e)[ ]


     6.   Citizenship Or Place Of Organization

          Delaware

                  7.  Sole Voting Power

Number Of         0 Shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              18,189 Shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 Shares

                  10.  Shared Dispositive Power

                  18,189 Shares


     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          18,189 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [X]

     13.  Percent Of Class Represented By Amount In Row (11)

          0.2%

     14.  Type Of Reporting Person (See Instructions)

          PN


<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    5 of 19


     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          OBP Management III LP; Tax Id No. 04-3480305


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e)[ ]


     6.   Citizenship Or Place Of Organization

          Delaware

                  7.  Sole Voting Power

Number Of         0 shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              1,547,529 shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 shares

                  10.  Shared Dispositive Power

                  1,547,529 shares


     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          1,547,529 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [X]

     13.  Percent Of Class Represented By Amount In Row (11)

          14.4%

     14.  Type Of Reporting Person (See Instructions)

           PN


<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    6 of 19




     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          OBP Management (Bermuda) III Limited Partnership;
          Tax Id No. 98-0212887


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e) [ ]


     6.   Citizenship Or Place Of Organization

          Bermuda

                  7.  Sole Voting Power

Number Of         0 Shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              220,555 Shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 Shares

                  10.  Shared Dispositive Power

                  220,555 Shares


     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          220,555 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [X]

     13.  Percent Of Class Represented By Amount In Row (11)

          2.0%

     14.  Type Of Reporting Person (See Instructions)

          PN



<PAGE>

                                  Schedule 13D
CUSIP No. 226901106                                                    7 of 19



     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          mRNA Partners L.P. ; Tax Id No. 04-3525524


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e) [ ]


     6.   Citizenship Or Place Of Organization

          Delaware

                  7.  Sole Voting Power

Number Of         0 Shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              18,189 Shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 Shares

                  10.  Shared Dispositive Power

                  18,189 Shares


     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          18,189 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [X]

     13.  Percent Of Class Represented By Amount In Row (11)

          0.2%

     14.  Type Of Reporting Person (See Instructions)

          PN


<PAGE>

                                  Schedule 13D
CUSIP No. 226901106                                                    8 of 19



     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          Jeffrey T. Barnes


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          PF, WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e) [ ]


     6.   Citizenship Or Place Of Organization

          United States

                  7.  Sole Voting Power

Number Of         1,000 shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              1,768,084 shares
Reporting
Person            9.  Sole Dispositive Power
With
                  1,000 shares

                  10.  Shared Dispositive Power

                  1,768,084 shares

     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          1,769,084 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [X]

     13.  Percent Of Class Represented By Amount In Row (11)

          16.4%

     14.  Type Of Reporting Person (See Instructions)

          IN

<PAGE>

                                  Schedule 13D
CUSIP No. 226901106                                                    9 of 19



     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          Jonathan J. Fleming


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e) [ ]


     6.   Citizenship Or Place Of Organization

          United States

                  7.  Sole Voting Power

Number Of         0 Shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              1,786,273 shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 Shares

                  10.  Shared Dispositive Power

                  1,786,273 shares


     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          1,786,273 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [ ]

     13.  Percent Of Class Represented By Amount In Row (11)

          16.6%

     14.  Type Of Reporting Person (See Instructions)

          IN

<PAGE>

                                  Schedule 13D
CUSIP No. 226901106                                                    10 of 19




     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          Michael J. Brennan


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e) [ ]


     6.   Citizenship Or Place Of Organization

          United States

                  7.  Sole Voting Power

Number Of         0 Shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              1,768,084 shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 Shares

                  10.  Shared Dispositive Power

                  1,768,084 shares


     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          1,768,084 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [X]

     13.  Percent Of Class Represented By Amount In Row (11)

          16.4%

     14.  Type Of Reporting Person (See Instructions)

          IN


<PAGE>

                                  Schedule 13D
CUSIP No. 226901106                                                    11 of 19




     1.   Names  Of  Reporting  Persons.  I.R.S.  Identification  Nos.  of Above
          Persons (entities only)

          Alan G. Walton


     2.   Check The Appropriate Box If A Member Of A Group (See Instructions)

          (a)  [ ]
          (b)  [X]

     3.   SEC Use Only


     4.   Source Of Funds (See Instructions)

          WC

     5.   Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To
          Items 2(d) Or 2(e) [ ]


     6.   Citizenship Or Place Of Organization

          United States

                  7.  Sole Voting Power

Number Of         0 Shares
Shares
Beneficially      8.  Shared Voting Power
Owned By
Each              1,786,273 shares
Reporting
Person            9.  Sole Dispositive Power
With
                  0 Shares

                  10.  Shared Dispositive Power

                  1,786,273 shares


     11.  Aggregate Amount Beneficially Owned By Each Reporting Person

          1,786,273 shares

     12.  Check Box If The Aggregate  Amount In Row (11) Excludes Certain Shares
          (See Instructions)

          [ ]

     13.  Percent Of Class Represented By Amount In Row (11)

          16.6%

     14.  Type Of Reporting Person (See Instructions)

          IN


<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    12 of 19


Item 1.  Security and Issuer.

         The class of equity  securities  to which  this  statement  relates  is
Common Stock, $0.04 par value ("Common Stock"),  of Criticare  Systems,  Inc., a
Delaware  corporation  ("Criticare"),  with principal executive offices at 20925
Crossroads Circle, Waukesha, WI 53186.

Item 2.  Identify and Background.

         The persons  filing this statement are Oxford  Bioscience  Partners III
LP, a Delaware limited  partnership ("OBP  Partners"),  OBP Management III LP, a
Delaware limited  partnership ("OBP  Management"),  Oxford  Bioscience  Partners
(Bermuda)  III  Limited   Partnership,   a  Bermuda  limited  partnership  ("OBP
Partners-Bermuda"),  OBP Management (Bermuda) III Limited Partnership, a Bermuda
limited  partnership  ("OBP  Bermuda  Management"),  mRNA Fund L.P. , a Delaware
limited partnership ("mRNA"),  mRNA Partners L.P. ("mRNA Partners"),  a Delaware
limited partnership,  Jeffrey T. Barnes, an individual ("Mr. Barnes"),  Jonathan
J. Fleming, an individual ("Mr.  Fleming"),  Alan G. Walton, an individual ("Mr.
Walton"),  and Michael J. Brennan, an individual ("Mr. Brennan")  (collectively,
the "Reporting Persons").

         OBP Partners'  principal  business is investing  venture capital in the
biotechnology  and healthcare  fields.  The principal office for OBP Partners is
located at 31 St. James Ave., Ste. 905, Boston, MA 02116.

         OBP Management's  principal business is managing  investment of venture
capital in the  biotechnology  and  healthcare  fields.  OBP  Management  is the
general  partner of OBP  Partners.  The principal  office for OBP  Management is
located at 31 St. James Ave., Ste. 905, Boston, MA 02116.

         OBP Partners-Bermuda's  principal business is investing venture capital
in the  biotechnology  and  healthcare  fields.  The  principal  office  for OBP
Partners-Bermuda is located at 31 St. James Ave., Ste. 905, Boston, MA 02116.

         OBP Bermuda  Management's  principal business is managing investment of
venture  capital  in  the  biotechnology  and  healthcare  fields.  OBP  Bermuda
Management is the general partner of OBP Partners-Bermuda.  The principal office
for OBP Bermuda Management is located at 31 St. James Ave., Ste. 905, Boston, MA
02116.

         mRNA's  principal   business  is  investing   venture  capital  in  the
biotechnology and healthcare fields. The principal office for mRNA is located at
31 St. James Ave., Ste. 905, Boston, MA 02116.

         mRNA  Partners'  principal  business is managing  investment of venture
capital in the biotechnology and healthcare fields. mRNA Partners is the general
partner of mRNA.  The  principal  office for mRNA  Partners is located at 31 St.
James Ave., Ste. 905, Boston, MA 02116.



<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    13 of 19



         Mr.  Barnes  is a  citizen  of  the  United  States  of  America  whose
occupation  is as a venture  capitalist  with Oxford  Bioscience  Partners.  Mr.
Barnes is a general  partner in OBP Management and OBP Bermuda  Management.  Mr.
Barnes' business address is Oxford Bioscience Partners,  31 St. James Ave., Ste.
905, Boston, MA 02116.

         Mr.  Fleming  is a  citizen  of the  United  States  of  America  whose
occupation  is as a venture  capitalist  with Oxford  Bioscience  Partners.  Mr.
Fleming is a general partner in OBP Management, OBP Bermuda Management, and mRNA
Partners.  Mr. Fleming's business address is Oxford Bioscience Partners,  31 St.
James Ave., Ste. 905, Boston, MA 02116.

         Mr.  Walton  is a  citizen  of  the  United  States  of  America  whose
occupation  is as a venture  capitalist  with Oxford  Bioscience  Partners.  Mr.
Walton is a general partner in OBP Management,  OBP Bermuda Management, and mRNA
Partners.  Mr. Walton's business address is Oxford Bioscience Partners, 315 Post
Road West, Westport, CT, 06880-5200.

         Mr.  Brennan  is a  citizen  of the  United  States  of  America  whose
occupation  is as a venture  capitalist  with Oxford  Bioscience  Partners.  Mr.
Brennan is a general partner in OBP Management and OBP Bermuda  Management.  Mr.
Brennan's  business address is Oxford  Bioscience  Partners,  31 St. James Ave.,
Ste. 905, Boston, MA 02116.

         None of the above-referenced  parties have, during the last five years,
been  convicted  in a criminal  proceeding  (excluding  traffic  violations  and
similar misdemeanors).

         None of the above-referenced  parties have, during the last five years,
been a party to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction resulting in a judgment,  decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws.

Item 3.  Source and Amount of Funds or Other Consideration.

         This statement relates to the acquisition by the following  entities of
Common Stock in the following  amounts for the  following  prices per share in a
private  placement  which  occurred on October 17, 2000 pursuant to that certain
purchase agreement filed herewith as Exhibit B:


      Purchaser                    Number of Shares             Price per Share

      -------------------------------------------------------------------------
      OBP Partners                  1,547,529                        $ 2.25
      OBP Partners-Bermuda            220,555                        $ 2.25
      mRNA                             18,189                        $ 2.25


         The  above-referenced  Common  Stock was  purchased  using the  working
capital of each of the respective purchasers.
<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    14 of 19


Item 4. Purpose of Transaction.

         The transaction  requiring the filing of this statement is described in
Item 3 above.  The  transactions  were entered into  principally  for investment
purposes.  In  connection  with  the  transaction,  the  board of  directors  of
Criticare was expanded by one seat and Mr. Barnes was elected to fill the vacant
seat on such board of directors.

         Each of OBP Partners, OBP Partners-Bermuda, and mRNA (collectively, the
"Funds" or any individual a "Fund") may make  purchases of Common Stock,  in the
open  market  or  in  private  transactions,  depending  on  their  analysis  of
Criticare's  business,  prospects and financial  condition,  the market for such
stock,  other  investment  and  business  opportunities  available to the Funds,
general economic and stock market conditions, proposals from time to time sought
by or presented to them and other factors.  Each of the Funds intends to closely
monitor its investment and may from time to time take advantage of opportunities
presented to it. Each Fund may in the future also  formulate  plans or proposals
regarding  Criticare,  including  possible future plans or proposals  concerning
events or  transactions  of the kind  described  in  paragraphs  (a) through (j)
below.

         Depending upon each Fund's  continuing  review of its  investments  and
various other factors, including those mentioned above, any Fund may (subject to
any  applicable  securities  laws) decide to sell all or any part of the shares,
although none of the Funds has current plans to do so.

         Except  as set forth in this Item 4, none of the Funds has any plans or
proposals which would relate to or result in:

         (a)  The  acquisition  by  any  person  of  additional   securities  of
Criticare, or the disposition of securities of Criticare;

         (b)  An  extraordinary   corporate  transaction,   such  as  a  merger,
reorganization or liquidation, involving Criticare or any of its subsidiaries;

         (c) A sale or transfer of a material  amount of assets of  Criticare or
any of its subsidiaries;

         (d) Any change in the  present  board of  directors  or  management  of
Criticare  including  any plans or  proposals  to change  the number or terms of
directors or to fill any existing vacancies on the board;

         (e) Any  material  change in the  present  capitalization  or  dividend
policy of Criticare;

         (f) Any other  material  change in  Criticare's  business or  corporate
structure;

         (g) Changes in Criticare's charter, bylaws or instruments corresponding
thereto  or other  actions  which may  impede  the  acquisition  of  control  of
Criticare by any person;

         (h) Causing a class of  securities  of Criticare to be delisted  from a
national  securities  exchange or to cease to be  authorized  to be quoted in an
inter-dealer quotation system of a registered national securities association;
<PAGE>

                                  Schedule 13D
CUSIP No. 226901106                                                    15 of 19


         (i) A class of equity  securities  of Criticare  becoming  eligible for
termination  of  registration  pursuant to Section  12(g)(4)  of the  Securities
Exchange Act of 1934; or

         (j)  Any action similar to any of those enumerated above.

Item 5.  Interest in Securities of the Issuer.

         (a) OBP Partners currently owns, and OBP Management  beneficially owns,
as general partner of OBP Partners,  and Mr. Barnes, Mr. Walton, Mr. Brennan and
Mr.  Fleming  beneficially  own,  each as general  partners  of OBP  Management,
1,547,529 shares of Common Stock which represents 14.4% of the Common Stock.

         OBP  Partners-Bermuda   currently  owns,  and  OBP  Bermuda  Management
beneficially owns, as general partner of OBP  Partners-Bermuda,  and Mr. Barnes,
Mr.  Walton,  Mr.  Brennan and Mr.  Fleming  beneficially  own,  each as general
partners  of OBP  Bermuda  Management,  220,555  shares  of Common  Stock  which
represents 2.1% of the Common Stock.

         mRNA currently  owns, and mRNA Partners  beneficially  owns, as general
partner of mRNA,  and Mr.  Fleming  and Mr.  Walton  beneficially  own,  each as
general  partners  of  mRNA  Partners,  18,189  shares  of  Common  Stock  which
represents 0.2% of the Common Stock.

         The Funds  collectively  hold  1,786,273  shares of Common  Stock which
represents 16.6% of the Common Stock.

         Mr. Barnes  beneficially  owns  1,769,084  shares of Common Stock which
represents 16.4% of the Common Stock.

         Mr. Brennan  beneficially  owns 1,768,084  shares of Common Stock which
represents 16.4% of the Common Stock.

         Mr. Fleming  beneficially  owns 1,786,273  shares of Common Stock which
represents 16.6% of the Common Stock.

         Mr. Walton  beneficially  owns  1,786,273  shares of Common Stock which
represents 16.6% of the Common Stock.

         The Reporting  Persons are making this joint filing because they may be
deemed to  constitute  a "group"  within the  meaning  of Rule  13d-5  under the
Securities  Exchange Act of 1934, as amended,  however  neither the fact of this
filing nor anything  contained  herein shall be deemed to be an admission by the
Reporting Persons that such a "group" exists.



<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    16 of 19

         (b)

                                  Voting Power              Dispositive Power
 Person                       Sole           Shared         Sole       Shared
 ------                       ----           ------         ----       ------
OBP Partners                    0          1,547,529          0      1,547,529
OBP Management                  0          1,547,529          0      1,547,529
OBP Partners-Bermuda            0            220,555          0        220,555
OBP Bermuda Management          0            220,555          0        220,555
mRNA                            0             18,189          0         18,189
mRNA Partners                   0             18,189          0         18,189
Mr. Barnes                  1,000          1,768,084      1,000      1,768,084
Mr. Fleming                     0          1,786,273          0      1,786,273
Mr. Walton                      0          1,786,273          0      1,786,273
Mr. Brennan                     0          1,768,084          0      1,768,084


         (c) Other than as may be described in Item 3, no transactions in Common
Stock have been effected  during the past sixty days by any of the parties named
in subsection (a) above.

         (d) No other  person is known to have the right to receive or the power
to direct the  receipt  of  dividends  from,  or the  proceeds  from the sale of
securities covered by this statement.

         (e)  Not Applicable.

Item 6.  Contracts, Arrangements, Understandings or Relationships
                with Respect to Securities of the Issuer.

         OBP  Management  is the general  partner of OBP Partners  pursuant to a
limited  partnership  agreement  which  authorizes OBP  Management,  among other
things,  to invest the funds of OBP Partners in the Common Stock and to vote and
dispose of the Common Stock. Pursuant to such limited partnership agreement, OBP
Management  is entitled to  allocations  based on assets  under  management  and
realized and unrealized  gains thereon.  Each of Mr. Barnes,  Mr.  Fleming,  Mr.
Walton,  and Mr. Brennan are general  partners of OBP  Management  pursuant to a
limited  partnership  agreement  which  authorizes  such persons to, among other
things,  direct OBP Management to invest the funds of OBP Partners in the Common
Stock and
<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    17 of 19


to vote and dispose of the Common  Stock.  Pursuant to such limited  partnership
agreement,  such  persons are  entitled  to  allocations  based on assets  under
management and realized and unrealized gains thereon.

         OBP Bermuda  Management is the general partner of OBP  Partners-Bermuda
pursuant  to a  limited  partnership  agreement  which  authorizes  OBP  Bermuda
Management,  among other things, to invest the funds of OBP  Partners-Bermuda in
the Common Stock and to vote and dispose of the Common  Stock.  Pursuant to such
limited partnership agreement, OBP Bermuda Management is entitled to allocations
based on assets under management and realized and unrealized gains thereon. Each
of Mr. Barnes, Mr. Fleming,  Mr. Walton, and Mr. Brennan are general partners of
OBP  Bermuda  Management  pursuant  to a  limited  partnership  agreement  which
authorizes such persons to, among other things, direct OBP Bermuda Management to
invest the funds of OBP  Partners-Bermuda  in the  Common  Stock and to vote and
dispose of the Common  Stock.  Pursuant to such limited  partnership  agreement,
such persons are entitled to  allocations  based on assets under  management and
realized and unrealized gains thereon.

         mRNA  Partners  is the  general  partner of mRNA  pursuant to a limited
partnership  agreement which  authorizes mRNA Partners,  among other things,  to
invest  the funds of mRNA in the  Common  Stock and to vote and  dispose  of the
Common Stock. Pursuant to such limited partnership  agreement,  mRNA Partners is
entitled to  allocations  based on assets  under  management  and  realized  and
unrealized  gains  thereon.  Each of Mr.  Fleming  and Mr.  Walton  are  general
partners of mRNA  Partners  pursuant to a limited  partnership  agreement  which
authorizes  such persons to, among other things,  direct mRNA Partners to invest
the funds of mRNA in the  Common  Stock and to vote and  dispose  of the  Common
Stock. Pursuant to such limited partnership agreement, such persons are entitled
to  allocations  based on assets under  management  and realized and  unrealized
gains thereon.

Item 7.  Material to be Filed as Exhibits.

         The following document is filed as an exhibit to this statement:

         Exhibit 99.A -  Agreement Regarding Joint Filing

         Exhibit 99.B -  Purchase Agreement dated as of October 17, 2000, by
                         and between Criticare Systems, Inc. and the Purchasers
                         (as defined therein).


<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    18 of 19



                                    SIGNATURE


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
current.

October 26, 2000




                                    OXFORD BIOSCIENCE PARTNERS III LP
                                    By:  OBP Management III LP


                                    By:  /s/ Jeffrey T. Barnes
                                         Jeffrey T. Barnes, its General Partner


<PAGE>
                                  Schedule 13D
CUSIP No. 226901106                                                    19 of 19



                                  EXHIBIT INDEX



                       99.A         Joint Filing Agreement

                       99.B         Criticare Systems Purchase Agreement




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