SEQUUS PHARMACEUTICALS INC
DEF 14A, 1995-08-10
PHARMACEUTICAL PREPARATIONS
Previous: JANUS CAPITAL CORP, SC 13G/A, 1995-08-10
Next: FIDELITY YEN PERFORMANCE PORTFOLIO LP, N-30D, 1995-08-10



<PAGE>
                                  SCHEDULE 14A
                                 (RULE 14A-101)
                    INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

          Proxy Statement Pursuant to Section 14(a) of the Securities
                    Exchange Act of 1934 (Amendment No.    )

   
    Filed by the registrant /X/
    Filed by a Party other than the registrant / /

    Check the appropriate box:
    / /  Preliminary proxy statement
    /X/  Definitive proxy statement
    / /  Definitive additional materials
    / /  Soliciting material pursuant to Rule 14a-11(c) or 14a-12

    

                               SEQUUS PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

--------------------------------------------------------------------------------
                   (Name of Person(s) Filing Proxy Statement)

Payment of filing fee (Check the appropriate box):

   
/ /  $125 per Exchange Act Rule 0-11(c)(1)(ii), 14a-6(i)(1), or 14a-6(j)(2).
/ /  $500  per each  party to  the controversy  pursuant to  Exchange Act Rule
     14a-6(i)(3).
/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
     (1) Title of each class of securities to which transaction applies:
        ----------------------------------------------------------------------
     (2) Aggregate number of securities to which transaction applies:
        ----------------------------------------------------------------------
     (3) Per unit  price  or other  underlying  value of  transaction  computed
        pursuant to Exchange Act Rule 0-11:(1)
        ----------------------------------------------------------------------
     (4) Proposed maximum aggregate value of transaction:
        ----------------------------------------------------------------------
/X/  Fee paid previously with preliminary materials.
/ /  Check  box if any part  of the fee is offset  as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee  was
     paid  previously. Identify the previous  filing by registration statement
     number, or the form or schedule and the date of its filing.
     (1) Amount previously paid:
        ----------------------------------------------------------------------
     (2) Form, schedule or registration statement no.:
        ----------------------------------------------------------------------
     (3) Filing party:
        ----------------------------------------------------------------------
     (4) Date filed:
        ----------------------------------------------------------------------

    

------------------------
   
(1)Set forth the amount on which the filing fee is calculated and state how it
was determined.
    
<PAGE>
                                     [LOGO]

                            ------------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                         TO BE HELD SEPTEMBER 12, 1995
                             ---------------------

TO THE STOCKHOLDERS OF SEQUUS PHARMACEUTICALS, INC.:

    The Annual Meeting of Stockholders of SEQUUS Pharmaceuticals, Inc. ("SEQUUS"
or  the "Company")  will be  held at  the offices  of the  Company, 960 Hamilton
Court, Menlo Park, California  94025, on September 12,  1995 at 9:00 a.m.  local
time, for the following purposes:

    1.  To  elect five directors to hold office until the next annual meeting of
        stockholders and until their successors are elected.

    2.  To approve an amendment to the Company's Certificate of Incorporation to
        increase the number of authorized shares of Common Stock from 35,000,000
        to 45,000,000.

    3.  To approve amendments to the  Company's 1987 Employee Stock Option  Plan
        to increase the number of shares reserved for issuance from 3,350,000 to
        5,000,000  and to impose  an annual limit  on the number  of shares with
        respect to which awards may be made to any one participant.

    4.  To approve an amendment  to the Company's  1987 Consultant Stock  Option
        Plan to increase the number of shares reserved for issuance from 100,000
        to 350,000.

    5.  To approve an amendment to the Company's 1990 Director Stock Option Plan
        to  increase the number of shares  reserved for issuance from 350,000 to
        600,000.

    6.  To approve an amendment to the Company's Employee Stock Purchase Plan to
        increase the  number of  shares reserved  for issuance  from 150,000  to
        250,000.

    7.  To transact such other business as properly may come before the meeting,
        or any adjournments or postponements of the meeting.

    The  matters expected to be acted upon  at the meeting are further described
in detail in the  attached proxy statement. Only  stockholders of record at  the
close  of business on July 21,  1995 are entitled to notice  of, and to vote at,
the meeting and any adjournments or postponements of the meeting.

                                          By Order of the Board of Directors,

   
                                          [sig]
                                          Sally A. Davenport,
                                          SECRETARY
    

Menlo Park, California
   
August 9, 1995
    

                                    IMPORTANT
WHETHER OR NOT  YOU EXPECT  TO ATTEND  THE MEETING  IN PERSON,  PLEASE SIGN  AND
RETURN  THE  ENCLOSED  PROXY  AS  SOON AS  POSSIBLE  IN  THE  ENCLOSED POST-PAID
ENVELOPE. THANK YOU FOR ACTING PROMPTLY.
<PAGE>
                               TABLE OF CONTENTS

   
<TABLE>
<CAPTION>
                                                                                                                PAGE
                                                                                                               -----
<S>                                                                                                          <C>
INFORMATION CONCERNING SOLICITATION AND VOTING.............................................................          1
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT.............................................          3
Proposal 1      ELECTION OF DIRECTORS......................................................................          5
  Information Concerning the Nominees......................................................................          5
  Board and Committee Meetings.............................................................................          6
  Director Compensation....................................................................................          6
  Executive Compensation...................................................................................          7
  Report on Repricing of Stock Options.....................................................................          9
  Report of the Board of Directors on Executive Compensation...............................................         10
  Compensation Committee Interlocks and Insider Participation..............................................         13
  Employment and Severance Agreements......................................................................         13
  Certain Transactions.....................................................................................         14
  Compliance With Section 16(a) of the Securities Exchange Act of 1934.....................................         14
  Stock Price Performance Graph............................................................................         14
Proposal 2      ADOPTION OF CERTIFICATE OF AMENDMENT OF THE COMPANY'S CERTIFICATE OF INCORPORATION.........         15
  Description of the Proposal..............................................................................         15
  Stockholder Vote.........................................................................................         15
Proposal 3      ADOPTION OF AMENDMENTS TO THE 1987 EMPLOYEE STOCK OPTION PLAN..............................         15
  Description of the Proposal..............................................................................         16
  Plan Description.........................................................................................         17
  Federal Income Tax Consequences..........................................................................         18
  Stockholder Vote.........................................................................................         18
Proposal 4      ADOPTION OF AMENDMENT TO THE 1987 CONSULTANT STOCK OPTION PLAN.............................         18
  Description of the Proposal..............................................................................         18
  Plan Description.........................................................................................         18
  Federal Income Tax Consequences..........................................................................         20
  Stockholder Vote.........................................................................................         20
Proposal 5      ADOPTION OF AMENDMENT TO THE 1990 DIRECTOR STOCK OPTION PLAN...............................         20
  Description of the Proposal..............................................................................         20
  Plan Description.........................................................................................         20
  Federal Income Tax Consequences..........................................................................         22
  Stockholder Vote.........................................................................................         22
Proposal 6      ADOPTION OF AMENDMENT TO THE EMPLOYEE STOCK PURCHASE PLAN..................................         22
  Description of the Proposal..............................................................................         22
  Plan Description.........................................................................................         23
  Federal Income Tax Consequences..........................................................................         24
  Stockholder Vote.........................................................................................         24
CERTAIN FEDERAL INCOME TAX CONSEQUENCES....................................................................         24
  Incentive Stock Options..................................................................................         24
  Nonqualified Stock Options...............................................................................         25
  Purchase Plan............................................................................................         26
  Special Federal Income Tax Consideration Due to Short Swing Profit Rule..................................         26
INDEPENDENT AUDITORS.......................................................................................         26
OTHER INFORMATION..........................................................................................         26
STOCKHOLDER PROPOSALS......................................................................................         27
OTHER MATTERS..............................................................................................         27
</TABLE>
    

                                       i
<PAGE>
                          SEQUUS PHARMACEUTICALS, INC.
                               960 HAMILTON COURT
                          MENLO PARK, CALIFORNIA 94025
                                 (415) 323-9011
                            ------------------------

                                PROXY STATEMENT
                             ---------------------

   
    The  enclosed proxy is  solicited on behalf  of the Board  of Directors (the
"Board") of SEQUUS  Pharmaceuticals, Inc., a  Delaware corporation ("SEQUUS"  or
the  "Company").  The  proxy is  solicited  for  use at  the  annual  meeting of
stockholders (the  "Annual  Meeting") to  be  held at  the  principal  executive
offices  of the  Company, 960 Hamilton  Court, Menlo Park,  California 94025, on
September 12, 1995 at 9:00 a.m., local time, and at any and all adjournments  or
postponements  thereof. The approximate  date on which  this proxy statement and
the accompanying notice and proxy are being mailed to stockholders is August  9,
1995.
    

                 INFORMATION CONCERNING SOLICITATION AND VOTING

    Only  stockholders of record at  the close of business  on July 21, 1995 are
entitled to notice of, and to vote  at, the Annual Meeting and any  adjournments
or postponements thereof. At the close of business on that date, the Company had
outstanding  21,518,519  shares  of Common  Stock,  par value  $.0001  per share
("Common Stock"), and  480,000 shares  of Series A  Convertible Reset  Preferred
Stock,  par  value  $0.01  per share  ("Convertible  Preferred  Stock").  On all
proposals to be submitted to the stockholders at the Annual Meeting, the holders
of the Common  Stock and  Convertible Preferred Stock  will vote  together as  a
single class. Holders of Common Stock are entitled to one vote for each share of
Common  Stock held. Holders of Convertible Preferred Stock are entitled to 3.367
votes for each share of Convertible Preferred Stock held. In order to constitute
a quorum for the conduct  of business at the Annual  Meeting, a majority of  the
outstanding  shares of Common Stock and Convertible Preferred Stock (measured by
the number of votes that may be cast by the holders of such shares) entitled  to
vote at the Annual Meeting must be represented at the Annual Meeting.

    All  shares represented by each  properly executed, unrevoked proxy received
in time for the Annual Meeting will be voted in the manner specified therein. If
the manner of  voting is  not specified  in an  executed proxy  received by  the
Company, the proxy will be voted FOR the election of the five nominees listed in
the  proxy for  election to the  Board and  FOR approval of  the other proposals
described in this proxy statement.

    Shares represented by proxies that  reflect abstentions or broker  non-votes
will  be counted as shares that are present and entitled to vote for purposes of
determining the presence of a quorum.  Directors will be elected by a  favorable
vote  of a plurality of the shares of voting stock present and entitled to vote,
in person or by proxy, at the Annual Meeting. Accordingly, abstentions or broker
non-votes as to the election  of directors will not  affect the election of  the
candidates  receiving the plurality of votes. All other proposals to come before
the Annual Meeting require the approval of a majority of the votes that could be
cast by  stockholders who  are present  or represented  at the  Annual  Meeting.
Abstentions  as to  a particular  proposal will  have the  same effect  as votes
against such proposal. Broker non-votes, however, will be treated as unvoted for
purposes of determining  approval of such  proposal and will  not be counted  as
votes for or against such proposal.

    Any stockholder giving a proxy in the form accompanying this proxy statement
has  the power to revoke the proxy prior to its exercise. A proxy can be revoked
by an instrument  of revocation  delivered prior to  the Annual  Meeting to  the
Secretary  of the Company, by  presenting at the Annual  Meeting a duly executed
proxy bearing a  later date or  time than the  date or time  of the proxy  being
revoked,  or at the Annual  Meeting if the stockholder  is present and elects to
vote in person. Mere attendance at the Annual Meeting will not serve to revoke a
proxy.

                                       1
<PAGE>
    The expense  of  soliciting  proxies  will be  borne  by  the  Company.  The
solicitation  will be by mail. Expenses  include reimbursement paid to brokerage
firms and others for their expenses incurred in forwarding solicitation material
regarding the  Annual  Meeting to  beneficial  owners of  the  Company's  stock.
Further  solicitation of proxies may be  made by telephone or oral communication
with stockholders by directors, officers and other employees of the Company  who
will  not receive additional  compensation for the  solicitation and by Chemical
Mellon Shareholder  Services, whose  services to  the Company  will include  the
solicitation  of  proxies from  brokers, banks  and nominees  for which  it will
receive payment of $5,000 plus out-of-pocket expenses.

                                       2
<PAGE>
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

    The  following  table  sets   forth  information  regarding  the   Company's
outstanding  shares of Common Stock and Convertible Preferred Stock beneficially
owned as of June 30, 1995 by: (i) each person who, to the best knowledge of  the
Company,  beneficially owns  more than  five percent  of the  outstanding Common
Stock or Convertible  Preferred Stock;  (ii) all directors;  (iii) all  officers
named  in  the Summary  Compensation  Table below;  and  (iv) all  directors and
officers as a group.  The information relating to  ownership of shares is  based
upon  information  furnished  to  the Company.  The  Company  believes  that the
beneficial owners of  the Common  Stock and Convertible  Preferred Stock  listed
below,  based on information  supplied by such owners,  have sole investment and
voting power  with  respect  to  the shares  of  Common  Stock  and  Convertible
Preferred  Stock shown as being beneficially  owned by them, except as otherwise
set forth in the footnotes to the table.

   
<TABLE>
<CAPTION>
                                                                                                                 CONVERTIBLE
                                                                                  COMMON STOCK                 PREFERRED STOCK
                                                                        ---------------------------------   ----------------------
                                                                           NUMBER OF           PERCENT OF   NUMBER OF   PERCENT OF
NAME AND ADDRESS                                                          SHARES (1)           CLASS (1)    SHARES (1)  CLASS (1)
----------------------------------------------------------------------  ---------------        ----------   ---------   ----------
<S>                                                                     <C>                    <C>          <C>         <C>
                                                                              2,316,786(2)        10.8%        --         --
Amerindo Technology Growth Fund, Inc. ................................
 780 Third Avenue, Suite 3204
 New York, NY 10017
                                                                              1,609,100            7.5         --         --
First Interstate Bancorp .............................................
 633 West 5th Street
 Los Angeles, CA 90074
                                                                              1,500,000(3)         7.0         --         --
Morgan Investment Corporation.........................................
                                                                              1,500,000(3)         7.0         --         --
J.P. Morgan & Co., Incorporated.......................................
                                                                              1,500,000(3)         7.0         --         --
J.P. Morgan Holdings, Inc. ...........................................
 902 Market Street
 Wilmington, DE 19801
                                                                              --                 --          100,000       20.8%
BT Holdings ..........................................................
 130 Liberty Street
 New York, NY 10006
                                                                              --                 --           48,000       10.0
SMALLCAP World Fund, Inc. ............................................
 333 S. Hope Street
 Los Angeles, CA 90071
                                                                              --                 --           44,000        9.2
H&Q Healthcare Investors .............................................
 50 Rowes Wharf
 Boston, MA 02110
                                                                              --                 --           36,000        7.5
H&Q Science Investors ................................................
 50 Rowes Wharf
 Boston, MA 02110
                                                                              --                 --           30,800        6.4
West Highland Partners, L.P. .........................................
 300 Drakes Landing Road
 Greenbrae, CA 94957
                                                                              --                 --           29,500        6.1
Oracle Partners, L.P. ................................................
 135 East 57th Street
 New York, NY 10022
                                                                                738,892(5)         3.4         --         --
Nicolaos V. Arvanitidis, Ph.D. (4)....................................
                                                                                 55,691           *            --         --
Robert G. Faris.......................................................
                                                                                142,500           *            --         --
I. Craig Henderson, M.D., F.A.C.P.....................................
                                                                                643,815(6)         2.9         --         --
Richard C.E. Morgan...................................................
                                                                                 36,100           *            --         --
Robert B. Shapiro (7).................................................
                                                                                 75,000           *            --         --
L. Scott Minick.......................................................
                                                                                 42,500           *            --         --
E. Donnall Thomas, M.D................................................
                                                                                 62,500           *            --         --
Joseph M. Limber......................................................
                                                                                 68,750           *            --         --
Richard D. Mamelok, M.D. (8)..........................................
                                                                                 23,336           *            --         --
Joseph J. Vallner, Ph.D...............................................
                                                                                 62,501           *            --         --
Peter V. Leigh (9)....................................................
                                                                              1,951,585(5)(6)      8.7         --         --
All directors and executive officers as a group (11 persons)..........
<FN>
------------------------------
 *   Less than 1%
</TABLE>
    

                                       3
<PAGE>

   
<TABLE>
<S>  <C>
(1)  Includes shares subject to warrants  or options exercisable within 60  days
     after  August 29, 1995,  as if such  shares were outstanding  on August 29,
     1995, and  assumes  that no  other  person has  exercised  any  outstanding
     warrants or options.

(2)  Includes 314,286 shares issuable upon exercise of warrants.

(3)  Includes  500,000 shares issuable upon exercise of warrants. All shares and
     warrants are held in the  name of Morgan Investment Corporation.  According
     to  Schedule 13D filed  by J.P. Morgan  & Co., Incorporated,  J.P. Morgan &
     Co., Incorporated, Morgan Investment Corporation and J.P. Morgan  Holdings,
     Inc. have shared voting and dispositive power with respect to all 1,500,000
     shares listed in the table.

(4)  Dr.  Arvanitidis  retired  as Chairman  of  the Board  and  Chief Executive
     Officer of the Company in June 1995.

(5)  Includes 13,880 shares held for the benefit of Dr. Arvanitidis' children.

(6)  Includes 565,565 shares held by Wolfensohn Associates, L.P. Mr. Morgan is a
     general partner of the general  partner of Wolfensohn Associates, L.P.  and
     therefore  may  be  deemed  to beneficially  own  such  shares.  Mr. Morgan
     disclaims beneficial ownership of such shares. Mr. Morgan shares voting and
     dispositive control of such shares with  the other general partners of  the
     general partner of Wolfensohn Associates, L.P.

(7)  Mr. Shapiro is currently a director of the Company, but is not standing for
     reelection at the Annual Meeting.

(8)  In April 1995, Dr. Mamelok stated his intention to resign from the Company.
     His resignation will not be effective until his successor is appointed.

(9)  Mr. Leigh resigned as an officer of the Company in April 1995.
</TABLE>
    

                                       4
<PAGE>
                                   PROPOSAL 1
                             ELECTION OF DIRECTORS

    The  Company's bylaws  provide for a  Board of Directors  consisting of that
number of directors as is authorized by  the Board. Effective as of the date  of
the  Annual Meeting, the size of the Board will be set at five. The present term
of office of all directors will expire at the Annual Meeting.

    Five directors are to be  elected at the Annual  Meeting to serve until  the
next  annual meeting of stockholders and  until their respective successors have
been elected.  The nominees  securing the  highest number  of votes,  up to  the
number  of directors to be elected, will be elected as directors. It is intended
that proxies received will be voted FOR the election of the nominees named below
unless marked  to the  contrary.  In the  event any  such  person is  unable  or
unwilling  to serve as a director, proxies  may be voted for substitute nominees
designated by the present Board. The Board has no reason to believe that any  of
the  persons named below will  be unable or unwilling to  serve as a director if
elected.

    All five nominees are currently serving as directors of the Company. Four of
the Company's five  nominees for  election to the  Board were  elected to  their
present  term by the stockholders of the  Company. Mr. Minick was elected to the
Board of Directors by the existing Board members in July 1995.

INFORMATION CONCERNING THE NOMINEES

    The following table indicates  the name and  age of each  nominee as of  the
date  of  this proxy  statement,  all positions  with  the Company  held  by the
nominee, and the year during which the nominee first was elected or appointed  a
director.

<TABLE>
<CAPTION>
                                                                                                      DIRECTOR
                                                                                                    CONTINUOUSLY
                  NAME                         AGE                POSITION WITH SEQUUS                  SINCE
-----------------------------------------      ---      -----------------------------------------  ---------------
<S>                                        <C>          <C>                                        <C>
I. Craig Henderson, M.D., F.A.C.P.                 53   Chairman of the Board and Chief Executive          1993
                                                         Officer
L. Scott Minick                                    43   President, Chief Operating Officer and             1995
                                                         Director
Robert G. Faris (1)(2)                             56   Director                                           1985
Richard C.E. Morgan (1)(2)                         50   Director                                           1990
E. Donnall Thomas, M.D.                            74   Director                                           1993
<FN>
------------------------
(1)  Member of the Compensation and Plan Committee of the Board.

(2)  Member of the Audit Committee of the Board.
</TABLE>

    I.  CRAIG  HENDERSON, M.D.,  F.A.C.P. has  been  Chief Executive  Officer of
SEQUUS since June 1995 and Chairman of the Board since July 1995 and has  served
as a director of the Company since July 1993. Since July 1995, Dr. Henderson has
been  an  Adjunct  Professor  of  Medicine  at  University  of  California,  San
Francisco. From 1992 until July 1995, he served as Professor of Medicine,  Chief
of  Medical Oncology and Director of  Clinical Cancer Programs at the University
of California, San Francisco. From 1974 to 1992, Dr. Henderson held an  academic
appointment  at Harvard Medical School, most  recently as Associate Professor of
Medicine. Dr. Henderson founded the Breast Evaluation Center at the  Dana-Farber
Cancer  Institute in 1980 and served as  its director until 1992. He received an
M.D. degree from Columbia University.

    L. SCOTT  MINICK has  been  President and  Chief  Operating Officer  of  the
Company since June 1995 and a director of the Company since July 1995. From 1994
to  1995, he served as a director, Interim President and Chief Executive Officer
of Oncotherapeutics, Inc. Before that, Mr. Minick was a director, President  and
Chief  Executive Officer of LXR Biotechnology, Inc. From 1981 to 1993, he was an
executive of Baxter Healthcare, Inc., most recently as President of the  Pacific
Rim/Latin America Division of Baxter Diagnostics.

                                       5
<PAGE>
    ROBERT  G. FARIS has served  as a director of  the Company since March 1985.
Since 1990, he has been President, Chief Executive Officer and a director of the
Polish American Enterprise Fund which  invests U.S. government funds in  Poland.
From  1971 to 1987, he served as President of Alan Patricof Associates, Inc., an
investment advisor to venture capital partnerships,  and from 1987 to 1990,  Mr.
Faris was a private investor.

    RICHARD  C.E. MORGAN has served as a director of the Company since May 1990.
Since 1986,  he has  been a  general  partner of  Wolfensohn Partners,  L.P.,  a
venture  capital  limited partnership,  and  the general  partner  of Wolfensohn
Associates, L.P.  From 1984  to 1986,  he served  as an  executive of  James  D.
Wolfensohn,  Inc., and from  1977 to 1984,  he served as  General Manager of The
Schroder Strategy  Group and  director of  J.  Henry Schroder  Wagg &  Co.  Ltd.
(London).  He  is a  director of  Lasertechnics,  Inc., Celgene  Corporation and
Quidel Corporation.

    E. DONNALL THOMAS, M.D. has served as a director of SEQUUS since July  1993.
Dr. Thomas currently is Professor Emeritus of Medicine, University of Washington
School  of  Medicine in  Seattle  and a  member  of the  Fred  Hutchinson Cancer
Research Center in Seattle. Dr. Thomas previously served, from 1974 to 1989,  as
Director  of Medical Oncology and Director  of Clinical Research Programs at the
Fred Hutchinson Cancer  Research Center and,  from 1963 to  1985, he headed  the
Division  of  Oncology at  the University  of Washington  School of  Medicine in
Seattle. Dr. Thomas received  the Nobel Prize in  Medicine and the  Presidential
Medal  of  Science in  1990. He  received  an M.D.  degree from  Harvard Medical
School.

    The Company  is not  aware of  any  family relationships  among any  of  the
foregoing directors and its executive officers.

BOARD AND COMMITTEE MEETINGS

    The  Board met four times during 1994. No incumbent director participated in
fewer than 75% of the total number  of meetings of the Board and all  committees
of  the Board on which he  served that were held during  the period he served on
the Board or such committees.

    The Compensation and Plan Committee did  not meet during 1994. The  function
of  the Compensation  and Plan Committee  is to  review and to  recommend to the
Board management  compensation  and to  administer  the Company's  stock  option
plans.  During  1994, the  Board  as a  whole  reviewed and  approved management
compensation issues  and  administered the  Company's  stock option  plans.  Dr.
Nicolaos  V. Arvanitidis,  who was Chief  Executive Officer and  Chairman of the
Board until his retirement in June 1995, abstained with respect to the  adoption
of  resolutions  pertaining to  his compensation  and  stock option  grants. See
"Report of Board of Directors on Executive Compensation" below.

    The Audit  Committee  met twice  during  1994.  The function  of  the  Audit
Committee  is to recommend to  the Board the firm  of independent accountants to
serve the Company, to  review the scope,  fees and results of  the audit by  the
independent  accountants and  to review the  internal control  procedures of the
Company.

    The Board does not have a nominating committee.

DIRECTOR COMPENSATION

    The Company pays each non-employee director a consulting fee for serving  as
a  director of the Company. During the  fiscal year ended December 31, 1994, the
Company paid consulting  fees of $10,000  to each of  Messrs. Faris, Morgan  and
Shapiro  in  consideration of  their services  as directors  of the  Company and
$22,000 to Dr.  Thomas and $78,750  to Dr. Henderson  in consideration of  their
services  as directors and consultants to  the Company. In addition, the Company
grants non-employee directors stock options under its 1990 Director Stock Option
Plan (the "1990 Director Plan"). Under the 1990 Director Plan, each non-employee
director of the  Company is  entitled to receive  an automatic  nondiscretionary
grant of nonqualified stock options to purchase 25,000 shares of Common Stock on
such director's first election to the Board. Each eligible director receives, in
each calendar year, an

                                       6
<PAGE>
automatic  nondiscretionary grant of  nonqualified stock options  to purchase an
additional 5,000 shares of Common Stock on the third business day following  the
release  to  the public  of the  Company's  annual financial  results; provided,
however, that a one-time grant of options to purchase 12,500 shares rather  than
5,000  shares was made in 1992 for eligible incumbent non-employee directors and
will be made to eligible newly elected non-employee directors on the date of the
first annual grant date following his or her election to the Board. No  eligible
director  may receive stock options to purchase more than an aggregate of 50,000
shares under the 1990 Director Plan. Messrs. Faris, Morgan and Shapiro have each
received options  to purchase  50,000  shares of  Common  Stock under  the  1990
Director  Plan. The exercise  price for shares subject  to stock options granted
under the 1990  Director Plan is  equal to the  fair market value  on the  grant
date.  Stock options are exercisable immediately  and generally expire ten years
from the date of  grant. See "Proposal  5 -- Adoption of  Amendment to the  1990
Director Stock Option Plan."

    During  1994, Dr. Arvanitidis, who served as Chairman of the Board and Chief
Executive Officer  until  his retirement  in  June  1995, did  not  receive  any
compensation from the Company for services rendered as a director beyond what he
received  for  services  as  an  officer of  the  Company.  The  cash  and other
compensation paid by the Company to  Dr. Arvanitidis for services as an  officer
of the Company during the fiscal year ended December 31, 1994 is set forth under
the caption "Executive Compensation" below.

EXECUTIVE COMPENSATION

    The  following table sets  forth information regarding  compensation for the
fiscal years ended December  31, 1992, 1993 and  1994 received by the  Company's
Chief  Executive Officer and the four  other most highly paid executive officers
who served as executive officers at fiscal year end (the "Named Officers").

                           SUMMARY COMPENSATION TABLE

   
<TABLE>
<CAPTION>
                                                                                             LONG TERM
                                                        ANNUAL COMPENSATION                COMPENSATION
 NAME AND PRINCIPAL POSITION              -----------------------------------------------     AWARDS
            AS OF                                                       OTHER ANNUAL       -------------       ALL OTHER
      DECEMBER 31, 1994          YEAR      SALARY($)   BONUS($)(1)     COMPENSATION($)      OPTIONS(#)    COMPENSATION($)(2)
-----------------------------  ---------  -----------  -----------  ---------------------  -------------  -------------------
<S>                            <C>        <C>          <C>          <C>                    <C>            <C>
Nicolaos V. Arvanitidis,            1994     250,008      125,000                 0           267,975(3)           3,750
 Ph.D.                              1993     240,504       93,753                 0               89,325           4,497
 Chairman of the Board              1992     219,420      142,065                 0                    0           2,182
 and Chief Executive Officer
 (4)(5)
Joseph M. Limber                    1994     128,400       37,615                 0             52,500             3,744
 Executive Vice President           1993     121,637       20,865                 0                  0             3,121
                                    1992      87,907        7,000                 0             60,000                 0
Richard Mamelok, M.D.               1994     184,056       47,866                 0             37,500             3,750
 Vice President and Medical         1993     177,624       29,909                 0                  0             4,451
 Director (6)                       1992      56,960        3,584                 0             75,000                 0
Peter V. Leigh                      1994     135,192       21,416                 0             37,500             3,750
 Vice President and Chief           1993     132,600       23,139                 0                  0             3,315
 Financial Officer (7)              1992      70,421        8,126                 0             75,000                 0
Joseph J. Vallner, Ph.D.            1994     142,392       39,456                 0          90,000(3)            14,136     (8)
 Senior Vice President for          1993     134,196       21,968                 0             20,000             1,992
 Research and Development           1992     113,000       12,600                 0             60,000                 0
<FN>
------------------------------
(1)  The bonus amounts earned in 1993 were paid in February and March 1994.  The
     bonus amounts earned in 1994 were paid in April 1995.

(2)  Except for the compensation described in footnote 8, the compensation shown
     in  this  column  reflects  the Company's  matching  contributions  for the
     employee to the Company's voluntary  salary reduction plan qualified  under
     Section  401(k) of the  Internal Revenue Code.  Such matching contributions
     consisted of Common Stock.
(3)  The 267,975 options  granted to Dr.  Arvanitidis and 60,000  of the  90,000
     options  granted  to Dr.  Vallner represent  options repriced  in September
     1994. See "Report on Repricing of Stock Options" below.
</TABLE>
    

                                       7
<PAGE>
   
<TABLE>
<S>  <C>
(4)  The bonus amounts  paid to  Dr. Arvanitidis for  1992 include  (a) a  bonus
     award  for 1991 of $103,950 paid in January  1992 and (b) a bonus award for
     1992 of $38,115 paid in December 1992.

(5)  Dr. Arvanitidis  retired  as Chairman  of  the Board  and  Chief  Executive
     Officer of the Company in June 1995.
(6)  In April 1995, Dr. Mamelok stated his intention to resign from the Company.
     His resignation will not be effective until his successor is appointed.
(7)  Mr. Leigh resigned as an officer of the Company in April 1995.
(8)  Includes  $12,000 principal amount of indebtedness to the Company cancelled
     in 1994. See "Certain Transactions" below.
</TABLE>
    

    The following table sets forth  further information regarding the grants  of
stock  options  during the  fiscal year  ended  December 31,  1994 to  the Named
Officers. Since inception, the  Company has not  granted any stock  appreciation
rights.

                       OPTION GRANTS IN LAST FISCAL YEAR

   
<TABLE>
<CAPTION>
                                                                 INDIVIDUAL GRANT
                                               -----------------------------------------------------    POTENTIAL REALIZABLE
                                                            PERCENTAGE OF                                 VALUE AT ASSUMED
                                                            TOTAL OPTIONS                              ANNUAL RATES OF STOCK
                                                             GRANTED TO                                PRICE APPRECIATION FOR
                                                OPTIONS     EMPLOYEES IN    EXERCISE OR                    OPTION TERM(2)
                                                GRANTED      FISCAL 1994    BASE PRICE    EXPIRATION   ----------------------
                    NAME                         (#)(1)          (%)         ($/SHARE)       DATE        5%($)       10%($)
---------------------------------------------  ----------   -------------   -----------   ----------   ----------  ----------
<S>                                            <C>          <C>             <C>           <C>          <C>         <C>
Nicolaos V. Arvanitidis, Ph.D. (4)             267,975(3)       17.13%         $6.75       6/26/00     $  499,747  $1,104,310
Joseph M. Limber                                52,500           3.36           7.75       6/14/04        255,882     648,454
Richard Mamelok, M.D. (5)                       37,500           2.40           6.75      10/21/96         25,945      53,156
Peter V. Leigh (6)                              37,500           2.40           7.75       6/16/96         29,789      61,031
Joseph J. Vallner, Ph.D.                        30,000           1.92           7.75       6/14/04        146,218     370,545
                                                60,000(3)        3.84           6.75       9/13/04        254,702     645,466
<FN>
------------------------------
(1)  Except  as  noted  in  footnote  3,  options  included  in  this  table are
     exercisable immediately upon grant; however, the Company retains a right to
     repurchase shares subject  to such  options at  the exercise  price in  the
     event the employee becomes no longer employed by the Company. Such right of
     repurchase  lapses over a  designated period of  the recipient's service to
     the Company (generally, four years with respect to initial grants and three
     years with respect to subsequent grants). In  the event of the sale of  the
     Company  or substantially  all of  the assets  or stock  thereof to another
     entity, or a merger in which the  Company is not the surviving entity,  the
     Company's  right of repurchase  with respect to all  shares subject to then
     outstanding  options  shall  expire   at  least  15   days  prior  to   the
     effectiveness of such transaction.
(2)  Potential realizable value is based on the assumption that the market price
     of  the stock appreciates at the stated rate, compounded annually, from the
     date of grant until the end of the option term. These values are calculated
     based on requirements promulgated by the Securities and Exchange Commission
     and  do  not  reflect  the   Company's  estimate  of  future  stock   price
     appreciation.
(3)  These  represent options that were repriced in September 1994. The repriced
     options vest over three  years following the offer  date, one third on  the
     first  anniversary  of the  repricing date,  with the  remaining two-thirds
     vesting ratably  on  a  quarterly  basis over  the  subsequent  two  years.
     However,  none of the repriced options  is exercisable until the earlier of
     (i) such date as the U.S. Food and Drug Administration ("FDA") approves the
     New   Drug    Application    ("NDA")    filed   by    the    Company    for
     DOXIL-Registered Trademark- (pegylated liposomal doxorubicin HCI) Injection
     or  (ii) September  12, 1999,  and only if  the employee  has been employed
     continuously by the Company at the time of such satisfaction of either such
     requirement. See "Report on Repricing of Stock Options" below.
(4)  Dr. Arvanitidis  retired  as Chairman  of  the Board  and  Chief  Executive
     Officer  of the Company in June 1995.  The options in this table originally
     had an expiration date of September  13, 2004. As part of Dr.  Arvanitidis'
     severance  arrangement,  he  has  until June  26,  2000  to  exercise these
     options. See "Employment and Severance Agreements" below.
(5)  In April 1995, Dr. Mamelok stated his intention to resign from the Company.
     His resignation will not be effective until his successor is appointed. The
     options in this table  originally had an expiration  date of September  13,
     2004.  As part of Dr. Mamelok's severance arrangement, he has until October
     16,  1996  to  exercise  these  options.  See  "Employment  and   Severance
     Agreements" below.
(6)  Mr.  Leigh resigned as an officer of the Company in April 1995. The options
     in this table originally had an expiration  date of June 14, 2004. As  part
     of  Mr.  Leigh's  severance arrangement,  he  has  until June  16,  1996 to
     exercise these options. See "Employment and Severance Agreements" below.
</TABLE>
    

    The following table  sets forth information  regarding options exercised  by
the  Named Officers during fiscal  1994 and the number  and value of unexercised
options held at fiscal year-end.

                                       8
<PAGE>
  AGGREGATED OPTION EXERCISES AND FISCAL YEAR-END OPTION VALUES IN LAST FISCAL
                                      YEAR

<TABLE>
<CAPTION>
                                                                        NUMBER OF UNEXERCISED       VALUE OF UNEXERCISED IN-THE-
                                                                        OPTIONS HELD AT FISCAL      MONEY OPTIONS AT FISCAL YEAR
                                                                             YEAR END(#)                     END($)(1)
                                                                      --------------------------  --------------------------------
                                   SHARES ACQUIRED        VALUE                    UNEXERCISABLE                  UNEXERCISABLE
              NAME                 ON EXERCISE(#)      REALIZED($)    EXERCISABLE       (2)       EXERCISABLE          (2)
--------------------------------  -----------------  ---------------  -----------  -------------  -----------  -------------------
<S>                               <C>                <C>              <C>          <C>            <C>          <C>
Nicolaos V. Arvanitidis Ph.D.(3)         --                --            177,299       267,975     $ 911,719           --
Joseph M. Limber                         --                --             30,000        82,500        --               --
Richard D. Mamelok, M.D. (4)             --                --             50,000        62,500        --               --
Peter V. Leigh (5)                       --                --             37,500        75,000        --               --
Joseph J. Vallner, Ph.D                  --                --             10,001        99,999        --               --
<FN>
------------------------------
(1)  Based on  the difference  between  the exercise  price  and the  per  share
     closing price of the Common Stock on the Nasdaq National Market on December
     30, 1994 ($6.44).

(2)  Generally,  options granted  to employees are  exercisable immediately upon
     grant; however,the Company retains a right to repurchase shares subject  to
     such  options at the  exercise price in  the event the  employee becomes no
     longer employed by  the Company.  Such right  of repurchase  lapses over  a
     designated  period of  the recipient's service  to the  Company. The shares
     listed in the  columns labeled  "unexercisable" are shares  subject to  the
     Company's  right  of repurchase.  Options  repriced in  September  1994 are
     subject to special restrictions on exercisability. See "Report on Repricing
     of Stock Options" below.

(3)  Dr. Arvanitidis  retired  as Chairman  of  the Board  and  Chief  Executive
     Officer of the Company in June 1995.

(4)  In April 1995, Dr. Mamelok stated his intention to resign from the Company.
     His resignation will not be effective until his successor is appointed.

(5)  Mr. Leigh resigned as an officer of the Company in April 1995.
</TABLE>

REPORT ON REPRICING OF STOCK OPTIONS

    In  September 1994,  the Board, with  Dr. Arvanitidis  abstaining, adopted a
"stock option swap" program, which the Board believed was necessary and  prudent
in order to retain the long-term incentive associated with potential stock price
appreciation  and  thus  value  of stock  options  to  all  employees, including
executive officers of the Company.

    The Company offered  all employees, including  executive officers, who  held
options  with an exercise price of $9.25  or greater the opportunity to exchange
those options for new options with an  exercise price of $6.75 (the fair  market
value  on  the date  of repricing).  Repriced options  will "vest"  one-third on
September 13, 1995  and the remaining  two-thirds ratably on  a quarterly  basis
over  the following two years, all based  on continued employment by the Company
on such  "vesting" date  (where "vesting"  is  determined by  the lapse  of  the
Company's  right  of repurchase).  Notwithstanding  the vesting  requirement, no
repriced option may be exercised until the  earlier of (i) such date as the  FDA
approves  the  DOXIL NDA  or  (ii) September  12,  1999, as  based  on continued
employment  by  the  Company  at  the  time  of  satisfaction  of  either   such
requirement.

                                       9
<PAGE>
    Options repriced from May 19, 1987, the date of the Company's initial public
offering,  through the  period ended  December 31,  1994 for  each of  the Named
Officers and other executive  officers employed by the  Company on December  31,
1994 are listed in the following table:

                           TEN YEAR OPTION REPRICINGS

<TABLE>
<CAPTION>
                                               NUMBER OF                     EXERCISE
                                              SECURITIES                     PRICE AT
                                              UNDERLYING   MARKET PRICE OF    TIME OF                     LENGTH OF
                                                OPTIONS     STOCK AT TIME    REPRICING                 ORIGINAL OPTION
                                              REPRICED OR  OF REPRICING OR      OR           NEW      TERM REMAINING AT
                                                AMENDED       AMENDMENT      AMENDMENT    EXERCISE    DATE OF REPRICING
        NAME AND POSITION            DATE         (#)            ($)            ($)       PRICE($)      OR AMENDMENT
---------------------------------  ---------  -----------  ---------------  -----------  -----------  -----------------
<S>                                <C>        <C>          <C>              <C>          <C>          <C>
Nicolaos V. Arvanitidis, Ph.D.       9/13/94      89,325      $    6.75      $   12.50    $    6.75          9.23 years
 Chairman of the Board and Chief     9/13/94     178,650           6.75         18.875         6.75          7.25 years
 Executive Officer(1)
Joseph J. Vallner, Ph.D              9/13/94      60,000           6.75          12.00         6.75          7.57 years
 Senior Vice President, Research
 and Development
Sally A. Davenport                   9/13/94       8,838           6.75          12.50         6.75          9.23 years
 Secretary                           9/13/94      17,675           6.75         18.875         6.75          7.25 years
Carl F. Grove                        9/13/94      18,529           6.75                        6.75          9.23 years
 Vice President for Regulatory       9/13/94      35,618           6.75          12.50         6.75          7.25 years
 Affairs                              1/9/89       5,000           2.50         18.875         3.00          8.25 years
                                                                                  4.25
Anthony A. Huang, Ph.D.              9/13/94      10,581           6.75          12.50         6.75          9.23 years
 Vice President of Product           9/13/94      15,873           6.75           9.25         6.75          7.25 years
 Development
Francis J. Martin, Ph.D              9/13/94      23,121           6.75          12.50         6.75          9.23 years
 Vice President and Chief            9/13/94      46,243           6.75         18.875         6.75          7.25 years
 Scientist                            1/9/89       5,000           2.50           4.25         3.00          8.25 years
Donald J. Stewart                    9/13/94      13,640           6.75          12.50         6.75          9.23 years
 Vice President, Finance             9/13/94      27,280           6.75         18.875         6.75          7.25 years
                                      1/9/89       5,000           2.50           4.25         3.00          8.25 years
Peter K. Working, Ph.D.              9/13/94      33,750           6.75           9.25         6.75          7.32 years
 Vice President of Preclinical
 Research
<FN>
------------------------------
(1)  Dr.  Arvanitidis  resigned as  Chairman of  the  Board and  Chief Executive
     Officer in June 1995.
</TABLE>

                                          Board of Directors (1)

                                              -- Robert G. Faris
                                             -- I. Craig Henderson, M.D.,
                                          F.A.C.P.
                                             -- Richard C.E. Morgan
                                             -- Robert B. Shapiro
                                             -- E. Donnall Thomas, M.D.
------------------------
(1) Mr. Shapiro is not standing for reelection at the Annual Meeting. Mr. Minick
    was elected to the Board  in July 1995, subsequent  to the repricing of  the
    options.

REPORT OF THE BOARD OF DIRECTORS ON EXECUTIVE COMPENSATION

    During  fiscal  1994, management  compensation issues  were reviewed  by the
Board as a whole, with Dr.  Arvanitidis abstaining with respect to the  adoption
of  resolutions pertaining to his compensation. The Board has a Compensation and
Plan Committee, the function of  which is to review  and recommend to the  Board
management  compensation and to administer the Company's stock option plans. The
Committee did not meet during 1994.

                                       10
<PAGE>
    The Company believes that its ability to achieve the objectives of obtaining
regulatory approval for and commercializing its leading pharmaceutical products,
AMPHOTEC-TM- (amphotericin  B colloidal  dispersion)  Injection and  DOXIL,  and
becoming  profitable, is dependent in large part upon the ability to recruit and
retain qualified  executives with  substantive  experience in  the  development,
regulatory  approval,  manufacture,  marketing and  sale  of  new pharmaceutical
products. The Company  is competing  for experienced executives  within the  San
Francisco Bay Area, where an estimated 85 to 100
biotechnology/biomedical/pharmaceutical  companies are located.  Due to the high
cost of housing relative to other parts of the country, and the  correspondingly
substantial  relocation  expenses  for  out-of-state  executives,  the Company's
recruiting efforts have been  focused on experienced  personnel who are  already
located in the Bay Area.

    In 1988, the Board adopted a policy designed to control the base salaries of
its  executives  while providing  sufficient  incentives to  attract  and retain
qualified personnel. In accordance with this policy, the Company strives to  set
executive  base salaries by considering relative contribution of the position to
achievement of the Company's goals and objectives, "market value" as defined  by
salaries of executives within the Bay Area with comparable experience in similar
positions,  and  job-related responsibilities  with respect  to size  of budget,
number of subordinates and scope of activities. In general, the Company  strives
to  set  base salaries  of new  executives at  market, which  is defined  as the
average base salary  of incumbents in  comparable positions, and  uses its  1987
Employee Stock Option Plan and its Executive Bonus Plan to facilitate recruiting
and to retain qualified executives by providing long-term incentives. Typically,
new  executives are  granted stock options  as part of  their initial employment
package.

    During 1993, the  Internal Revenue  Code of 1986  was amended  to include  a
provision  that denies a deduction to publicly held corporation for compensation
paid to "covered employees" (defined as the chief executive officer and the next
four most highly compensated officers as of the end of the taxable year) to  the
extent  that compensation paid  to any "covered employee"  exceeds $1 million in
any  taxable   year   of  the   corporation   beginning  after   1993.   Certain
"performance-based"  compensation qualifies for an  exemption from the limits on
deductions. It is the Company's policy  to qualify compensation paid to its  top
executives  for  deductibility in  order to  maximize  the Company's  income tax
deductions,  to  the  extent  that   so  qualifying  the  compensation  is   not
inconsistent  with the  Company's fundamental compensation  policies. Based upon
the Internal Revenue Service's proposed regulations and compensation paid to the
Company's "covered employees" for  the 1994 tax year,  all compensation paid  by
the Company in 1994 to such covered employees was deductible to the Company.

    STOCK OPTIONS

    The Company has determined that stock options are an important incentive for
attracting   and  retaining   qualified  personnel,   including  executive-level
personnel. Accordingly, all new  employees may receive  an initial stock  option
grant  upon employment by the  Company. Each employee, including executive-level
employees, may receive a subsequent stock  option grant two years following  the
initial  grant at the discretion of the Board. In 1994, three executive officers
received such stock  options following stock  options granted to  them in  1992.
Generally,  each option is  immediately exercisable, but  the shares issued upon
option exercise  are subject  to a  right  of repurchase  by the  Company  which
generally expires over a period of four years with respect to initial grants and
three  years with respect to subsequent grants. In 1994, the Company offered all
employees, including executive officers, the ability to exchange certain options
for options  with a  lower exercise  price. See  "Report on  Repricing of  Stock
Options" above.

    CORPORATE PERFORMANCE CRITERIA

    The  Company presents to the Board a set of corporate goals for a succeeding
period, generally ranging from 12 to 18  months, as part of the annual plan  and
budget process. These goals establish benchmarks for assessing overall corporate
performance.  Given  the dynamic  nature of  the  new drug  development process,
progress toward the achievement  of corporate goals is  reviewed with the  Board
periodically  together with  a description of  any change  in circumstances that
management believes

                                       11
<PAGE>
may warrant an update  to or revisions of  these goals. The principal  corporate
goals  for 1994 were related to the  following: support of launch of AMPHOTEC in
the United Kingdom; filing of additional Marketing Approval Application  ("MAA")
dossiers  for AMPHOTEC  throughout Western  and Eastern  Europe and  in selected
South American countries; filing of  the NDA with the  FDA for DOXIL; filing  of
MAA  dossiers for DOXIL throughout the European Union countries; preparing for a
successful meeting with the FDA's Oncologic Drugs Advisory Committee ("ODAC") to
review the  DOXIL NDA  (subsequently,  in February  1995, the  Company  received
ODAC's  recommendation  to  the  FDA for  approval  of  DOXIL  under accelerated
approval regulations); initiating  additional dose-ranging  clinical studies  of
DOXIL  in  various  solid  tumors; and,  identifying  new  product opportunities
utilizing the Company's proprietary platform long-circulating
STEALTH-Registered Trademark- liposome technology.

    EXECUTIVE BONUS PLAN

    Under the  Executive  Bonus  Plan,  each of  the  Chief  Executive  Officer,
President,  Vice Presidents, Corporate Secretary and Treasurer of the Company is
eligible to receive a  cash bonus ranging  from 50% to 150%  of the amounts  set
forth  below based on  the Board's assessment  of overall corporate performance.
The bonus  amounts  based  upon  corporate performance  are  as  follows:  Chief
Executive  Officer -- 50% of base salary;  President -- 50% of base salary; Vice
Presidents -- 15% of base salary;  and Corporate Secretary and Treasurer --  10%
of  base salary. In April 1995, the Board  awarded 100% of the bonus amounts set
forth above to eligible  executive officers based on  the Board's assessment  of
corporate  performance during fiscal 1994. In addition to the bonus awards based
upon corporate performance, each of the Vice Presidents, the Corporate Secretary
and the Treasurer  is eligible  to receive  up to 10%  of base  salary based  on
individual  performance. For 1994,  each eligible executive  received a bonus of
10% of base salary, which was paid in April 1995.

    PERIODIC SALARY ADJUSTMENTS

    Generally, executive salaries are  reviewed annually and salary  adjustments
may  be  awarded  on  the  basis  of  increased  responsibilities  of individual
executives over a period  of time or the  outstanding performance of  individual
executives  as  exhibited by  consistently high  standards  in the  execution of
established duties, as described  by the Chief Executive  Officer to the  Board.
Company  performance as a whole is a major consideration in the Board's decision
to award any salary increases and, to a lesser extent, the Board also  considers
general  economic conditions  and trends. In  1994, the base  annual salaries of
eight Company executives were increased by 5.6%. These increases, which occurred
in April 1995 and  were retroactive to July  1994, were considered and  approved
solely  by  members of  the  Board of  Directors who  are  not employees  of the
Company.

    CHIEF EXECUTIVE OFFICER COMPENSATION

    Generally, the  non-employee  members  of  the Board  meet  with  the  Chief
Executive Officer to discuss the performance of the other executive officers and
of  the Company as a whole. The members of the Board then meet in the absence of
the Chief Executive Officer and other employee members of the Board, if any,  to
discuss  the performance  of the  Chief Executive  Officer and  the Company. Dr.
Arvanitidis received a bonus  for 1994 of  $125,000, or 50%  of his base  annual
salary,  in accordance with the Executive  Bonus Plan described above, which was
paid in April 1995.

    SUMMARY

    The Board believes that it has established a program for compensation of the
Company's executives which is fair and which aligns the financial incentives for
executives with the interests of the Company's stockholders.

                                       12
<PAGE>
                                          Board of Directors (1)

                                              -- Nicolaos V. Arvanitidis, Ph.D.
                                             -- Robert G. Faris
                                             -- I. Craig Henderson, M.D.,
                                          F.A.C.P.
                                             -- Richard C.E. Morgan
                                             -- Robert B. Shapiro
                                             -- E. Donnall Thomas, M.D.
------------------------
(1) Dr. Arvanitidis retired from the Board  in June 1995 and Mr. Shapiro is  not
    standing  for reelection  at the  Annual Meeting.  Both were  members of the
    Board when the compensation decisions described above were made. Mr.  Minick
    was  elected  to the  Board  in July  1995,  subsequent to  the compensation
    decisions described above.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

    During  fiscal  1994,  management  compensation  issues  were  reviewed  and
approved  by the Board of Directors as  a whole, with Dr. Arvanitidis abstaining
with respect to the adoption of resolutions pertaining to his compensation.  The
Compensation  and  Plan Committee  during fiscal  1994  was composed  of Messrs.
Morgan and Shapiro and Dr. Henderson. The function of the Committee is to review
and recommend  to  the  Board  management compensation  and  to  administer  the
Company's  stock option plans.  During fiscal 1994, no  executive officer of the
Company served on the  board of directors or  compensation committee of  another
company  that had an executive officer serve on the Company's Board of Directors
or its Compensation and Plan Committee.

EMPLOYMENT AND SEVERANCE AGREEMENTS

    The Company is  party to employment  agreements with Dr.  Henderson and  Mr.
Minick  and Ms.  Davenport, a  founder of the  Company. The  agreements with Dr.
Henderson and Mr.  Minick each have  a ten-year  term and provide  that if  such
officer  is terminated either without  cause or upon a  change in control of the
Company, he will  receive compensation equal  to 18 months  of his then  current
base salary if the termination occurs prior to June 27, 1996 or 12 months of his
then  current base salary if the  termination occurs thereafter. Dr. Henderson's
current base salary is $275,000. Mr.  Minick's current base salary is  $225,000.
The  agreement  with  Ms.  Davenport  provides  for  an  automatically renewable
one-year term of  employment terminable  by either  party upon  90 days'  notice
prior to the end of each term.

    The Company and Dr. Arvanitidis are party to a memorandum of agreement dated
as  of April  3, 1995,  as amended,  (the "MOA").  Dr. Arvanitidis  retired from
serving as Chairman of the Board and  Chief Executive Officer on June 26,  1995.
The MOA sets forth the essential terms of Dr. Arvanitidis' retirement. Under the
MOA,  the Company is obligated to pay  Dr. Arvanitidis his annual base salary of
$250,000  through  December  31,  1995  and  a  bonus  of  $125,000.  After  his
retirement,  Dr. Arvanitidis will provide up to  120 hours of consulting time to
the Company. The Company has agreed  to pay an additional $671,245 of  severance
pay to Dr. Arvanitidis. The Company's right of repurchase lapsed with respect to
all  shares of Common  Stock underlying Dr. Arvanitidis'  stock options upon his
retirement and the exercise period of all  but 102,392 of his stock options  was
extended   to  the  fifth  anniversary  of  his  retirement.  In  addition,  Dr.
Arvanitidis will receive certain health and life insurance benefits and will  be
permitted to retain his Company car.

    The  Company also entered into severance arrangements with Mr. Leigh and Dr.
Mamelok relating to their resignations from the Company. The Company has  agreed
to  pay Mr. Leigh severance pay of $71,388, which is equal to six months of base
salary. The exercise period of Mr. Leigh's options has been extended until  June
16,  1996, and the Company has agreed to accelerate the vesting of 62,500 shares
underlying Mr.  Leigh's  options.  Vesting  on  the  remaining  shares  will  be
accelerated  in the event of a sale of all or substantially all of the Company's
assets or stock, or a merger in which SEQUUS is not the surviving company, which
occurs before June 16,  1996. Dr. Mamelok's relationship  with the Company  will
end  at  the  date  determined  by his  successor.  The  Company  has  agreed to

                                       13
<PAGE>
pay Dr. Mamelok $47,796 upon his termination, which is equal to three months  of
base salary. Dr. Mamelok's stock options will continue to vest until October 21,
1995,  and the exercise period  for the options has  been extended until October
21, 1996.

CERTAIN TRANSACTIONS

   
    On October 5, 1993, the Company agreed to make an unsecured loan of  $60,000
to  Joseph  Vallner,  Senior Vice  President  for Research  and  Development, to
facilitate his purchase of a  new residence. The loan has  a term of five  years
and accrues interest at the prime rate, as published by the Wall Street Journal,
plus  1%. On each annual anniversary of the loan take-down date, 20% of the loan
principal will  be  forgiven by  the  Company  provided Mr.  Vallner  remains  a
full-time  employee of the Company through the anniversary. In 1994, the Company
paid I. Craig Henderson, M.D. $78,750 for services as a director and  consultant
to the Company. See "Director Compensation" above.
    

COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT OF 1934

    Section  16(a)  of the  Securities  Exchange Act  of  1934, as  amended (the
"Exchange Act"), requires  the Company's directors  and executive officers,  and
persons  who own more than ten percent  of the outstanding Common Stock, to file
with the Securities and Exchange Commission ("SEC") initial reports of ownership
and reports of  changes in ownership  of the Company's  Common Stock.  Officers,
directors  and  greater  than  ten  percent  stockholders  are  required  by SEC
regulations to furnish the Company with  copies of all Section 16(a) forms  they
file.

    To  the Company's knowledge,  based solely on  review of the  copies of such
reports furnished to or  maintained by the  Company and written  representations
that  no other reports were required, during  the fiscal year ended December 31,
1994,  all  Section  16(a)  filing  requirements  applicable  to  the  Company's
officers,  directors  and greater  than ten  percent stockholders  were complied
with, except that  the form  for one  transaction by  Mr. Joseph  M. Limber,  an
officer  of the Company, was filed late, and the form for one transaction by Dr.
Francis J. Martin, an officer of the Company, was filed late.

STOCK PRICE PERFORMANCE GRAPH

    The  following  line  graph  illustrates  a  five-year  comparison  of   the
cumulative  total stockholder return on the  Common Stock against the cumulative
total  return  of  the  Nasdaq  Stock   Market  (U.S.)  Index  and  the   Nasdaq
Pharmaceutical  Stock Index, assuming $100 invested  in the Common Stock and the
two indexes on December 31, 1989.

                      CUMULATIVE TOTAL STOCKHOLDER RETURN

EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC

<TABLE>
<CAPTION>
            SEQUUS PHARMACEUTICALS, INC. (SEQU)    NASDAQ STOCK MARKET (US)   NASDAQ PHARMACEUTICAL STOCKS
<S>        <C>                                    <C>                         <C>
Dec-89                                       100                         100                            100
Dec-90                                       180                          85                            120
Dec-91                                      1480                         136                            319
Dec-92                                       800                         159                            266
Dec-93                                       720                         181                            212
Dec-94                                       516                         177                            178
</TABLE>

                                       14
<PAGE>
                                   PROPOSAL 2

                    ADOPTION OF CERTIFICATE OF AMENDMENT OF
                   THE COMPANY'S CERTIFICATE OF INCORPORATION

    The Board of Directors unanimously adopted, subject to stockholder approval,
a  Certificate of Amendment  of the Company's  Certificate of Incorporation (the
"Certificate of Amendment") increasing the number of authorized shares of Common
Stock from 35,000,000 to 45,000,000. The  stockholders are asked to approve  the
adoption of the Certificate of Amendment, which is attached as Exhibit I to this
proxy statement.

DESCRIPTION OF THE PROPOSAL

    As  of June  30, 1995,  the Company  had 21,379,591  shares of  Common Stock
outstanding and  approximately 8,278,694  shares of  Common Stock  reserved  for
issuance  under  the  Company's  stock purchase  plan,  stock  option  plans and
outstanding warrants and  upon conversion of  outstanding Convertible  Preferred
Stock.  As of June 30,  1995, the Company had  approximately 5,341,715 shares of
Common Stock  authorized but  unissued  and unreserved.  If the  Certificate  of
Amendment  is approved and if the proposed amendments to the 1987 Employee Stock
Option Plan, the  1987 Consultant  Stock Option  Plan, the  1990 Director  Stock
Option  Plan, and the Employee Stock Purchase Plan described below are approved,
the Company will have an additional 7,750,000 shares of Common Stock  authorized
but unreserved. The Company intends to use the additional shares of Common Stock
for  future  financings, but  does not  at  present have  any specific  plans or
arrangements which are  expected to  result in  the issuance  of any  additional
shares of Common Stock that have not been previously reserved.

    The  Board is authorized to approve  the issuance of additional Common Stock
at any time. Although  the increase in  the authorized number  of shares is  not
proposed  for  the purpose  of any  anti-takeover effect,  the issuance  of such
shares may have  an anti-takeover  effect, depending  upon the  identity of  the
purchasers,  the  number of  shares  issued and  the  then current  ownership of
outstanding  shares  of  the  Company.  The  purpose  of  the  increase  in  the
authorization  is the  elimination of  later delays  associated with stockholder
votes on  specific issuances.  The  Bylaws of  the  NASD generally  require  the
Company  nevertheless to obtain the approval  of stockholders holding at least a
majority of the shares of  the Company voting for  the issuance of Common  Stock
(or  securities convertible  or exercisable  for Common  Stock) pursuant  to any
stock option or purchase  plan in which officers  or directors may  participate,
resulting  in a  change in  control of the  Company, in  connection with certain
acquisitions of  the stock  or  assets of  another  corporation, or  in  private
placements  for a price less than the  greater of book or market value involving
20% or more of the Common Stock outstanding before the issuance.

STOCKHOLDER VOTE

    The affirmative  vote  of  a  majority  of  votes  that  could  be  cast  by
stockholders who are present or represented at the Annual Meeting is required to
adopt the Certificate of Amendment. Properly executed, unrevoked proxies will be
voted  FOR  Proposal  2  unless  a vote  against  Proposal  2  or  abstention is
specifically indicated in the proxy.

    THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR ADOPTION OF THE CERTIFICATE  OF
AMENDMENT.

                                   PROPOSAL 3
                           ADOPTION OF AMENDMENTS TO
                      THE 1987 EMPLOYEE STOCK OPTION PLAN

    The Board of Directors unanimously adopted, subject to stockholder approval,
amendments  to the Company's 1987 Employee Stock Option Plan (the "1987 Employee
Plan") increasing the number

                                       15
<PAGE>
of shares reserved for issuance thereunder  and imposing an annual limit on  the
number of shares of Common Stock with respect to which option awards may be made
to  any one  participant thereunder. The  stockholders are asked  to approve the
adoption of the amendments to the 1987 Employee Plan.

DESCRIPTION OF THE PROPOSAL

    Currently, the 1987 Employee Plan provides that a total of 3,350,000  shares
of  Common Stock may  be issued thereunder.  The proposed amendment  to the 1987
Employee Plan increases the number  of shares available for issuance  thereunder
by  1,650,000 shares  to a total  of 5,000,000  shares, in order  to ensure that
there will be a sufficient reserve of shares to permit further option grants  to
existing  and new employees of the Company. As of June 30, 1995, the Company had
granted options covering 553,277 shares of Common Stock in excess of the  number
of  shares available for grant under the 1987 Employee Plan prior to approval of
the amendments proposed hereby. If the  proposed amendment to the 1987  Employee
Plan  to increase the aggregate number of shares available for grant is approved
by the stockholders, the number of options available for grant will be 1,096,723
(assuming no options have been granted, been exercised or expired since June 30,
1995).

    None of the Named Officers have been granted options under the 1987 Employee
Plan that are subject to the  stockholders approving the proposed amendments  to
the  1987 Employee Plan. The following table shows the number of options granted
under the 1987 Employee Plan that are subject to the stockholders approving  the
proposed  amendments  to the  1987 Employee  Plan to  the named  individuals and
groups.

                                 PLAN BENEFITS

<TABLE>
<CAPTION>
                                                                                    NUMBER OF
NAME AND POSITION                                                                  OPTIONS (1)
---------------------------------------------------------------------------------  -----------
<S>                                                                                <C>
I. Craig Henderson, M.D., F.A.C.P. ..............................................     350,000
 Chairman of the Board and Chief Executive Officer
L. Scott Minick .................................................................     275,000
 President, Chief Operating Officer and Director
All executive officers as a group................................................     625,000
All directors who are not executive officers as a group..........................           0
All employees (other than executive officers) as a group.........................           0
<FN>
------------------------
(1)  All options granted at fair market value as of the date of grant.
</TABLE>

    Section 162(m)  of  the Internal  Revenue  Code  of 1986,  as  amended  (the
"Code"),  enacted  in  August  1993, limits  (subject  to  some  exemptions) the
deductibility by public companies  of compensation in excess  of $1 million  per
year  (per executive) paid to certain executive officers (generally, the CEO and
the next four most highly compensated executive officers). As the limit  applies
in  the year in which the compensation is paid, it could apply to income derived
from the exercise of certain stock  options, measured by the spread between  the
exercise price and the fair market value at the time the option is exercised.

    "Performance-based"  compensation  does  not  count  toward  the  $1 million
deduction limit if certain conditions  are met. Compensation resulting from  the
exercise  of stock options  will be treated  as "performance-based" and excluded
from the limit on deductibility if, among other things, the plan under which the
options are  granted  specifies limits  on  the  number of  shares  issuable  to
executive  officers under the plan and these limits are approved by the issuer's
stockholders.

    In order  to  exclude  from  the $1  million  deduction  limit  compensation
resulting from the exercise of options granted under the 1987 Employee Plan, the
Board  has adopted,  subject to stockholder  approval, an amendment  to the 1987
Employee Plan to limit the number of shares with respect to which options may be
granted to no more than 400,000 shares to any one participant in any year.

                                       16
<PAGE>
PLAN DESCRIPTION

    The 1987 Employee Plan  authorizes the granting  of incentive stock  options
("ISOs")  as defined  in Section 422  of the  Internal Revenue Code  of 1986, as
amended (the  "Code"),  and  non-qualified  stock  options  ("NQOs").  The  1987
Employee Plan is not subject to the provisions of the Employee Retirement Income
Security  Act of  1974, as amended,  and is  not a qualified  plan under Section
401(a) of the Code.  Proceeds received by  the Company from  the sale of  Common
Stock  pursuant to the exercise of options  under the 1987 Employee Plan will be
used for general corporate purposes.

    The 1987  Employee  Plan  is  administered  by  the  Board  or  a  committee
established   by  the   Board  (in   either  case,   the  "Administrator").  The
Administrator  is  authorized  to  select  from  among  eligible  employees  the
individuals to whom options are granted, to determine the number of shares to be
subject  to such options, to designate whether such options will be ISOs or NQOs
and to determine the  terms and conditions of  the options, consistent with  the
1987 Employee Plan. No election by an employee is required to participate in the
1987 Employee Plan.

    Any  full-time employee (including officers) of the Company or the Company's
subsidiaries or parent corporation is eligible  to be granted options under  the
1987  Employee Plan.  As of  June 30, 1995,  approximately 155  employees of the
Company were eligible to participate in the 1987 Employee Plan.

    No options may be  granted under the 1987  Employee Plan after December  10,
1997.  Options granted before termination of  the 1987 Employee Plan will remain
exercisable in accordance with their  respective terms after termination of  the
1987 Employee Plan.

   
    The  1987  Employee Plan  requires that  the option  price for  NQOs granted
thereunder be not less than 85% of the fair market value of the Common Stock  on
the  date of grant  and requires that  ISOs granted thereunder  be not less than
100% of the fair market value of the Common Stock on the date of grant (or  110%
of  the fair market value  in the case of  an ISO granted to  a person who owns,
directly or indirectly, more than 10% of the total combined voting power of  all
classes of stock of the Company). On July 31, 1995, the closing sales price of a
share of the Common Stock on the Nasdaq National Market was $11.25.
    

    No  option may be  exercised after the  expiration of a  period of ten years
from the date of grant in the case of  ISOs and ten years and two days from  the
date  of grant  in the  case of NQOs,  subject to  the earlier  expiration of an
option for the reasons described below.

    Incentive  stock  options  granted  to  persons  then  owning,  directly  or
indirectly,  more than 10% of the total  combined voting power of all classes of
stock of the Company, any subsidiary or parent corporation, may not be exercised
after the expiration of five years from  the date of grant. Each option  becomes
exercisable  at such times and in such installments (which may be cumulative) as
the Administrator  shall  provide  in  the  terms  of  each  individual  option.
Generally,  each  option granted  under the  1987  Employee Plan  is immediately
exercisable, but the  shares issued  upon option exercise  may be  subject to  a
right of repurchase by the Company at the option exercise price upon termination
of  employment, which  right generally  expires over a  period of  three or four
years. In the  event of  the sale  of the Company  or substantially  all of  the
assets  or stock thereof to another entity, or  a merger in which the Company is
not the surviving entity, the Company's right of repurchase with respect to  all
shares  subject to then outstanding options shall  expire at least 15 days prior
to the effectiveness of such transaction.

    Under the 1987  Employee Plan, the  right to exercise  any option  generally
expires  three months  after an optionee's  termination of  employment (or seven
months with respect to optionees subject to Section 16(b) of the Exchange  Act),
but  if the optionee dies or becomes disabled while employed by the Company, any
outstanding option will expire one year from the date of the optionee's death or
termination due to the disability.

                                       17
<PAGE>
    The 1987  Employee Plan  may be  wholly or  partially amended  or  otherwise
modified,  suspended or terminated at any time  by the Board. No such amendment,
suspension  or  termination  may,  however,  alter  or  impair  the  rights   or
obligations  of the holders  of outstanding options without  the consent of such
holders. In addition,  without the  approval of the  Company's stockholders,  no
action  of the  Administrator may  increase the limit  on the  maximum number of
shares which  may  be issued  on  exercise of  options  granted under  the  1987
Employee  Plan (except  for anti-dilutive  adjustments), modify  the eligibility
requirements for the  1987 Employee  Plan, or extend  the duration  of the  1987
Employee Plan.

    No  option granted under  the 1987 Employee Plan  is transferable, except by
will or by the applicable laws of descent and distribution.

FEDERAL INCOME TAX CONSEQUENCES

    See "Certain Federal Income Tax Consequences" below for a discussion of  the
federal  income tax consequences  relating to ISOs and  NQOs granted pursuant to
the 1987 Employee Plan.

STOCKHOLDER VOTE

    The affirmative  vote of  a majority  of the  votes that  could be  cast  by
stockholders who are present or represented at the Annual Meeting is required to
adopt  the proposed  amendments to  the 1987  Employee Plan.  Properly executed,
unrevoked proxies will be voted FOR Proposal 3 unless a vote against Proposal  3
or abstention is specifically indicated in the proxy.

    THE  BOARD  OF DIRECTORS  RECOMMENDS  A VOTE  FOR  ADOPTION OF  THE PROPOSED
AMENDMENTS TO THE 1987 EMPLOYEE PLAN.

                                   PROPOSAL 4
                            ADOPTION OF AMENDMENT TO
                     THE 1987 CONSULTANT STOCK OPTION PLAN

    The Board of Directors unanimously adopted, subject to stockholder approval,
an amendment  to the  Company's 1987  Consultant Stock  Option Plan  (the  "1987
Consultant  Plan")  increasing  the  number  of  shares  reserved  for  issuance
thereunder. The stockholders are asked to approve the adoption of this amendment
to the 1987 Consultant Plan.

DESCRIPTION OF THE PROPOSAL

    Currently, the 1987 Consultant Plan provides that a total of 100,000  shares
of  Common Stock may  be issued thereunder.  The proposed amendment  to the 1987
Consultant Plan increases the number of shares available for issuance thereunder
by 250,000 shares to a  total of 350,000 shares, in  order to ensure that  there
will  be  a sufficient  reserve of  shares  to permit  further option  grants to
existing and  new consultants  to the  Company. Officers  and directors  of  the
Company are not eligible to receive options under the 1987 Consultant Plan.

    As  of June 30, 1995, options covering 33,800 shares of the Company's Common
Stock were available for grant under  the 1987 Consultant Plan. If the  proposed
amendment to the 1987 Consultant Plan to increase the aggregate number of shares
available  for  grant is  approved by  the stockholders,  the number  of options
available for grant will be increased to 283,800 (assuming no options have  been
granted, been exercised or expired since June 30, 1995).

PLAN DESCRIPTION

    The  1987  Consultant  Plan  authorizes the  granting  of  NQOs  to eligible
consultants to the Company. The purpose of the 1987 Consultant Plan is to enable
the Company to encourage selected  consultants to accept or continue  consulting
arrangements  with the  Company or its  affiliates and increase  the interest of
selected consultants in the Company's welfare through their participation in the
growth and value of the Company. The 1987 Consultant Plan is not subject to  the
provisions of the

                                       18
<PAGE>
Employee  Retirement  Income Security  Act of  1974,  as amended,  and is  not a
qualified plan  under Section  401(a)  of the  Code.  Proceeds received  by  the
Company  from the sale of Common Stock  pursuant to the exercise of options will
be used for general corporate purposes.

    Any consultant (including persons employed by, or otherwise affiliated with,
a consultant) to the Company or the Company's subsidiaries or parent corporation
is eligible to be granted  NQOs under the 1987 Consultant  Plan. As of June  30,
1995,  approximately 12 consultants to the  Company were eligible to participate
in the 1987 Consultant Plan.
    The 1987  Consultant  Plan is  administered  by  the Board  or  a  committee
established   by  the   Board  (in   either  case,   the  "Administrator").  The
Administrator is authorized to  select from among  the eligible consultants  the
consultants to whom options are to be granted, to determine the number of shares
to  be subject to such options and to  determine the terms and conditions of the
options, consistent with the 1987 Consultant Plan. No election by any consultant
is required to participate in the 1987 Consultant Plan.

    No options may be granted under the 1987 Consultant Plan after December  10,
1997. Options granted before termination of the 1987 Consultant Plan will remain
exercisable  in accordance with their respective  terms after termination of the
1987 Consultant Plan.
    The 1987 Consultant Plan requires that the option price for options  granted
be not less than 85% of the fair market value of the Common Stock on the date of
grant  (or 110% of the fair market value  in the case of any person who directly
or indirectly owns  more than  10% of  the total  combined voting  power of  all
classes of stock of the Company).

    No  option may be exercised  in whole or in part,  after the expiration of a
period of ten years and two days from the date of grant, subject to the  earlier
expiration  of an  option for  the reasons  described below.  Options granted to
persons then owning, directly or indirectly, more than 10% of the total combined
voting power of all classes  of stock of the  Company, any subsidiary or  parent
corporation,  may not be exercised  after the expiration of  five years from the
date of  grant.  Each option  becomes  exercisable at  such  times and  in  such
installments (which may be cumulative) as the Administrator shall provide in the
terms  of each individual option. Generally,  each option granted under the 1987
Consultant Plan is immediately exercisable, but the shares issued upon  exercise
may  be subject to a  right of repurchase by the  Company at the option exercise
price upon termination of the consultancy, which right generally expires over  a
period  not exceeding  two years.  In the event  of the  sale of  the Company or
substantially all of the assets or stock thereof to another entity, or a  merger
in  which  the Company  is  not the  surviving  entity, the  Company's  right of
repurchase with respect to all shares subject to then outstanding options  shall
expire at least 15 days prior to the effectiveness of such transaction.

    Under  the 1987 Consultant Plan, the  right to exercise any option generally
expires three months after  an optionee's termination  of consultancy (or  seven
months  with respect to optionees subject to Section 16(b) of the Exchange Act),
but if the optionee dies  or becomes disabled while  engaged as a consultant  by
the  Company,  any outstanding  option will  expire  one year  from the  date of
optionee's death or termination due to disability.

    The stockholders of  the Company  must approve  all amendments  to the  1987
Consultant  Plan which  increase the number  of shares which  are authorized for
issuance upon exercise of options (except for anti-dilution adjustments), modify
the eligibility  requirements, or  extend the  duration of  the 1987  Consultant
Plan. In all other respects, the 1987 Consultant Plan may be amended, suspended,
or  terminated by the Board. No  such amendment, suspension, or termination may,
however, alter or impair the rights or obligations of the holders of outstanding
options without the consent of such holders.

    No option granted under the 1987 Consultant Plan is transferable, except  by
will or by the applicable laws of descent and distribution.

                                       19
<PAGE>
FEDERAL INCOME TAX CONSEQUENCES

    See  "Certain Federal Income Tax Consequences" below for a discussion of the
federal income tax consequences  relating to NQOs granted  pursuant to the  1987
Consultant Plan.

STOCKHOLDER VOTE

    The  affirmative  vote of  a majority  of the  votes that  could be  cast by
stockholders who are present or represented at the Annual Meeting is required to
adopt the  Second Amendment  to  the 1987  Consultant Plan.  Properly  executed,
unrevoked  proxies will be voted FOR Proposal 4 unless a vote against Proposal 4
or abstention is specifically indicated in the proxy.

    THE BOARD OF DIRECTORS  RECOMMENDS A VOTE FOR  ADOPTION OF THE AMENDMENT  TO
THE 1987 CONSULTANT PLAN.

                                   PROPOSAL 5
                            ADOPTION OF AMENDMENT TO
                      THE 1990 DIRECTOR STOCK OPTION PLAN

    The Board of Directors unanimously adopted, subject to stockholder approval,
an  amendment  to  the Company's  1990  Director  Stock Option  Plan  (the "1990
Director  Plan")  increasing  the  number   of  shares  reserved  for   issuance
thereunder. The stockholders are asked to approve the adoption of this amendment
to the 1990 Director Plan.

DESCRIPTION OF THE PROPOSAL

    Currently, the 1990 Director Plan provides that a total of 350,000 shares of
Common  Stock  may be  issued  thereunder. The  proposed  amendment to  the 1990
Director Plan increases the number  of shares available for issuance  thereunder
by  250,000 shares to a  total of 600,000 shares, in  order to ensure that there
will be a sufficient reserve of shares to attract new directors to the Company.

    Executive officers of the Company are not eligible to receive NQOs under the
1990 Director Plan. The following table shows, assuming that all of the nominees
are elected at the Annual Meeting, the  number of NQOs which will be granted  to
the listed groups under the 1990 Director Plan in 1996.

<TABLE>
<CAPTION>
                                                                                     NUMBER OF
                                                                                     NQOS (1)
                                                                                    -----------
<S>                                                                                 <C>
All executive officers as a group.................................................           0
All directors who are not executive officers as a group...........................       5,000
All employees (other than executive officers) as a group..........................           0
<FN>
------------------------
(1)  All options granted at fair market value as of the date of grant.
</TABLE>

    As  of June 30,  1995, options covering  35,000 shares of  Common Stock were
available for grant under the 1990  Director Plan. If the proposed amendment  to
the  1990 Director Plan to increase the aggregate number of shares available for
grant is approved by the stockholders, the number of options available for grant
will be increased to 285,000.

PLAN DESCRIPTION

    The 1990 Director Plan provides  NQOs to eligible non-employee directors  of
the   Company  at  set  times  and  in  set  amounts.  However,  to  the  extent
administration is  required, it  is  provided by  the  Board of  Directors.  The
purpose  of the 1990 Director Plan is to enable the Company to obtain and retain
the services of, and to motivate, experienced non-employee directors  considered
essential  to the long-range  success of the Company,  by providing and offering
them an opportunity to become owners of Common Stock of the Company pursuant  to
the  exercise of options granted under the 1990 Director Plan. The 1990 Director
Plan is  not  subject  to  the provisions  of  the  Employee  Retirement  Income

                                       20
<PAGE>
Security  Act of 1974, as amended, and it  is not a qualified plan under Section
401(a) of the Code.  Proceeds received by  the Company from  the sale of  Common
Stock  pursuant  to the  exercise of  NQOs  will be  used for  general corporate
purposes.

    Each member of  the Board of  Directors of the  Company who is  not also  an
employee  of  the Company  or  any subsidiary  or  affiliate of  the  Company is
eligible to participate in the  1990 Director Plan upon  his or her election  or
appointment  to the Board  of Directors of the  Company; provided, however, that
any nonemployee director  who beneficially  owns 10%  or more  of the  Company's
outstanding  shares of Common Stock is ineligible. After the Annual Meeting, the
Company will have one  non-employee director eligible  to participate under  the
1990  Director  Plan if  the  nominees named  in  this proxy  statement  are all
elected. No eligible  director may  receive NQOs  to purchase  more than  50,000
shares under the 1990 Director Plan.

    All  eligible non-employee  directors of the  Company who  were directors on
January 31, 1990 were granted automatically, as of January 31, 1990, an  initial
NQO  to purchase  25,000 shares of  Common Stock.  Thereafter, each non-employee
director who was a director  on January 31, 1990 has  been and shall be  granted
automatically  an additional  NQO covering 5,000  shares of Common  Stock on the
third business day following the release  to the public of the Company's  annual
financial  results;  provided, however,  that  in 1992  each  eligible incumbent
non-employee director received  a one-time grant  of an NQO  to purchase  12,500
shares  in lieu of  the grant of  an NQO to  purchase 5,000 shares  which he was
entitled to receive that year. A  person who becomes a non-employee director  is
granted  automatically, as of the date of  his or her election or appointment to
the Company's Board  of Directors, an  NQO to purchase  25,000 shares of  Common
Stock,  and thereafter shall be granted automatically an additional NQO covering
5,000 shares of Common Stock on the third business day following the release  to
the  public of the  Company's annual financial  results; provided, however, that
each new eligible non-employee director shall  receive a one-time grant, on  the
date  of the first annual grant date following his or her election to the Board,
of an NQO to purchase 12,500 shares in  lieu of the grant of an NQO to  purchase
5,000 which such new director would be entitled to receive on the same date.

    No  NQOs may be granted under the 1990 Director Plan after January 31, 2000.
NQOs  granted  before  termination  of  the  1990  Director  Plan  will   remain
exercisable  in accordance with their respective  terms after termination of the
1990 Director Plan.

    The price per share of the Common Stock subject to each option shall be  the
closing  sales price of the  Common Stock, or the closing  bid price if no sales
were reported, on  the Nasdaq  National Market,  on the  date of  grant of  such
option,  or  on the  last preceding  business day  if  the grant  date is  not a
business day. NQOs granted under the 1990 Director Plan are exercisable in  full
upon  grant. The right to exercise any NQO generally expires upon the earlier of
ten years from the date of grant or one year after a director's termination as a
director.

    The 1990  Director Plan  may be  wholly or  partially amended  or  otherwise
modified,  suspended or terminated at any time  by the Board of Directors of the
Company. However, without the approval of the Company's stockholders, no  action
of the Board may increase the limit on the maximum number of shares which may be
issued  on exercise of options granted under  the 1990 Director Plan (except for
anti-dilutive adjustments),  modify the  eligibility requirements  for the  1990
Director  Plan,  change the  minimum option  price,  or materially  increase the
benefits accruing under the 1990 Director Plan.

    No option granted under  the 1990 Director Plan  is transferable, except  by
will or by the applicable laws of descent and distribution.

    As  of April 28, 1995,  NQOs to purchase 315,000  shares of Common Stock had
been granted  and were  outstanding under  the 1990  Director Plan  at  exercise
prices  ranging  from $1.8125  to $18.6250  per  share, including  10,000 shares
granted on the 1995 annual grant date.

                                       21
<PAGE>
FEDERAL INCOME TAX CONSEQUENCES

    See "Certain Federal Income Tax Consequences" below for a discussion of  the
federal  income tax consequences  relating to NQOs granted  pursuant to the 1990
Director Plan.

STOCKHOLDER VOTE

    The affirmative  vote of  a majority  of the  votes that  could be  cast  by
stockholders who are present or represented at the Annual Meeting is required to
adopt  the  proposed amendment  to the  1990  Director Plan.  Properly executed,
unrevoked proxies will be voted FOR Proposal 5 unless a vote against Proposal  5
or abstention is specifically indicated in the proxy.

    THE  BOARD  OF DIRECTORS  RECOMMENDS  A VOTE  FOR  ADOPTION OF  THE PROPOSED
AMENDMENT TO THE 1990 DIRECTOR PLAN.

                                   PROPOSAL 6
                            ADOPTION OF AMENDMENT TO
                        THE EMPLOYEE STOCK PURCHASE PLAN

    The Board of Directors unanimously adopted, subject to stockholder approval,
an amendment to the Company's Employee Stock Purchase Plan (the "Purchase Plan")
increasing  the  number  of  shares   reserved  for  issuance  thereunder.   The
stockholders are asked to approve the adoption of this amendment to the Purchase
Plan.

DESCRIPTION OF THE PROPOSAL

    Currently,  the Purchase Plan provides that a total of 150,000 shares may be
issued thereunder. The  proposed amendment  to the Purchase  Plan increases  the
number of shares available for issuance thereunder to a total of 250,000 shares,
in  order to ensure that there will be  a sufficient reserve of shares to permit
further purchases by existing and new employees of the Company.

    The following  table shows  the  number of  shares  purchased by  the  Named
Officers  and the  identified groups  under the  Purchase Plan  in 1994  and the
"Dollar Value" of those shares. The "Dollar Value" is the difference between the
fair market  value  of  the Common  Stock  on  the dates  of  purchase  and  the
participant's purchase price.

                                       22
<PAGE>
                                 PLAN BENEFITS

<TABLE>
<CAPTION>
                                                                                      DOLLAR       NUMBER
NAME AND POSITION                                                                    VALUE ($)    OF SHARES
----------------------------------------------------------------------------------  -----------  -----------
<S>                                                                                 <C>          <C>
Nicolaos J. Arvanitidis, Ph.D. ...................................................           0            0
 Chairman of the Board and
 Chief Executive Officer (1)
Joseph M. Limber .................................................................       1,133        1,117
 Executive Vice President
Richard Mamelok, M.D. ............................................................       2,435        2,441
 Vice President and Medical Director (2)
Peter V. Leigh ...................................................................           0            0
 Vice President and Chief Financial Officer (3)
Joseph J. Vallner, Ph.D. .........................................................         503          507
 Senior Vice President for
 Research and Development
All executive officers as a group.................................................       4,071        4,065
All directors who are executive officers as a group...............................           0            0
All employees (other than executive officers) as a group..........................      48,745       43,924
<FN>
------------------------
(1)  Dr.  Arvanitidis  retired  as Chairman  of  the Board  and  Chief Executive
     Officer of the Company in June 1995.

(2)  In April 1995, Dr. Mamelok stated his intention to resign from the Company.
     His resignation will not be effective until his successor is appointed.

(3)  Mr. Leigh resigned as an officer of the Company in April 1995.
</TABLE>

    As of June  30, 1995, approximately  47,085 shares of  the Company's  Common
Stock  were  available for  purchase under  the Purchase  Plan. If  the proposed
amendment to the Purchase  Plan is approved by  the stockholders, the number  of
shares available for purchase will be increased to approximately 147,085.

PLAN DESCRIPTION

    All  employees,  including officers  and directors  who are  also employees,
customarily employed 20 or more hours per week and five or more months each year
by the Company, are eligible to participate in the Purchase Plan as of the first
enrollment date  following one  year  of employment  by the  Company;  provided,
however,  that any person who holds 5% or  more of the Company's Common Stock is
prohibited from participating in  the Purchase Plan.  Any eligible employee  may
enroll  in the Purchase Plan as of the first trading day of January, April, July
or  October  of  each  year  (or  other  enrollment  dates  established  by  the
administrator  of the  Purchase Plan).  As of  June 30,  1995, approximately 155
employees of the Company were eligible to participate in the Purchase Plan.

    The Purchase Plan is administered by  the Board of Directors of the  Company
or  a committee established by  the Board. The Board  may amend or terminate the
Purchase Plan at any time. However,  amendments which would increase the  number
of  shares subject to the Purchase Plan, materially increase the benefits to the
participants or  materially modify  the requirements  for participation  require
stockholder approval.

    Participating employees may elect to make contributions to the Purchase Plan
at  a rate  equal to  any whole  percentage, up  to a  maximum of  10% (or other
percentage set by  the Board  of Directors) of  monthly base  earnings from  the
Company.  On  the last  trading day  of  each quarter  (or other  purchase dates
established by the Board of Directors), the Company will apply the funds then in
the employee's

                                       23
<PAGE>
account to the purchase of shares. The  cost for each share purchased is 85%  of
the lower of the closing prices for Common Stock on the first trading day in the
enrollment  period in  which the  purchase is  made and  the purchase  date. The
length of the enrollment period is established from time to time by the Board of
Directors but may not exceed 27 months. At any time before a scheduled  purchase
date a participant may elect to withdraw funds contributed to the Purchase Plan.
No  employee is permitted under the Purchase  Plan to purchase Common Stock at a
rate which exceeds $25,000 of fair  market value of Common Stock (determined  as
of  the first trading day  in an enrollment period) in  any year. The Board will
set the  maximum  number  of  shares that  may  be  purchased  by  participating
employees during any enrollment period.

FEDERAL INCOME TAX CONSEQUENCES

    See  "Certain Federal  Income Tax  Consequences" below  for a  discussion of
federal income tax consequences relating to participation in the Purchase Plan.

STOCKHOLDER VOTE

    The affirmative  vote of  a majority  of the  votes that  could be  cast  by
stockholders who are present or represented at the Annual Meeting is required to
adopt  the proposed amendment to the Purchase Plan. Properly executed, unrevoked
proxies will  be voted  FOR  Proposal 6  unless a  vote  against Proposal  6  or
abstention is specifically indicated in the proxy.

    THE  BOARD  OF DIRECTORS  RECOMMENDS  A VOTE  FOR  ADOPTION OF  THE PROPOSED
AMENDMENT TO THE PURCHASE PLAN.

                    CERTAIN FEDERAL INCOME TAX CONSEQUENCES

    THE FOLLOWING  SUMMARY OF  FEDERAL  INCOME TAX  CONSEQUENCES IS  BASED  UPON
EXISTING STATUTES, REGULATIONS AND INTERPRETATIONS THEREOF. THE APPLICABLE RULES
ARE  COMPLEX, AND INCOME TAX CONSEQUENCES MAY VARY DEPENDING UPON THE PARTICULAR
CIRCUMSTANCES OF EACH PLAN PARTICIPANT.  THIS PROXY STATEMENT DESCRIBES  FEDERAL
INCOME  TAX  CONSEQUENCES  OF GENERAL  APPLICABILITY,  BUT DOES  NOT  PURPORT TO
DESCRIBE PARTICULAR CONSEQUENCES TO EACH INDIVIDUAL PLAN PARTICIPANT OR FOREIGN,
STATE OR LOCAL INCOME TAX CONSEQUENCES, WHICH MAY DIFFER FROM THE UNITED  STATES
FEDERAL INCOME TAX CONSEQUENCES.

INCENTIVE STOCK OPTIONS

    AWARD;  EXERCISE.  ISOs are intended to constitute "incentive stock options"
within the meaning  of Section  422 of  the Code. ISOs  may be  granted only  to
employees  of  the  Company (including  directors  who are  also  employees). An
optionee does not recognize taxable income upon either the grant or exercise  of
an  ISO. However, the  excess of the  fair market value  of the shares purchased
upon exercise over the option exercise price (the "Option Spread") is includable
in the optionee's "alternative minimum taxable income" ("AMTI") for purposes  of
the  alternative minimum tax ("AMT"). The Option Spread is generally measured on
the date of exercise and is includable in AMTI in the year of exercise.  Special
rules  regarding the time  of AMTI inclusion  may apply for  shares subject to a
repurchase right or other  "substantial risk of  forfeiture" (including, in  the
case  of each person subject to the  reporting requirements of Section 16 of the
Exchange Act, limitations on resale of shares imposed under Section 16(b) of the
Exchange Act).

    SALE OF OPTION SHARES.  If an  optionee holds the shares purchased under  an
ISO  for at least two years  from the date the ISO  was granted and for at least
one year from the date the ISO was exercised, any gain from a sale of the shares
other than to  the Company  is taxable as  long-term capital  gain. Under  these
circumstances,  the Company would not be entitled to a tax deduction at the time
the ISO is exercised or at  the time the stock is  sold. If an optionee were  to
dispose  of stock  acquired pursuant to  an ISO  before the end  of the required
holding periods (a "Disqualifying Disposition"), the amount by which the  market
value  of the stock at the time the  ISO is exercised exceeds the exercise price
(or, if

                                       24
<PAGE>
less, the amount of gain  realized on the sale)  is taxable as ordinary  income,
and  the Company is  entitled to a  corresponding tax deduction.  Such income is
subject  to  information  reporting  requirements  and  may  become  subject  to
withholding.  Gain  from a  Disqualifying Disposition  in  excess of  the amount
required to be  recognized as  ordinary income  is capital  gain. Optionees  are
required  to  notify the  Company immediately  prior  to making  a Disqualifying
Disposition. If stock is sold to the  Company rather than to a third party,  the
sale  may not produce capital gain or loss. A sale of shares to the Company will
constitute a redemption  of such shares,  which could be  taxable as a  dividend
unless  the redemption is "not essentially  equivalent to a dividend" within the
meaning of  the Code.  The timing  and  amount of  income from  a  Disqualifying
Disposition  and the beginning of the  optionee's holding period for determining
whether capital gain or loss  is long- or short-term  may be affected if  option
stock  is acquired subject to  a repurchase right or  other "substantial risk of
forfeiture" (including  in the  case of  each person  subject to  the  reporting
requirements  of Section 16 of the Exchange Act, limitations on resale of shares
imposed under Section 16(b) of the Exchange Act).

    EXERCISE WITH STOCK.  If an optionee pays for ISO shares with shares of  the
Company  acquired  under an  ISO  or a  qualified  employee stock  purchase plan
("statutory option stock"), the tender of shares is a Disqualifying  Disposition
of  the  statutory option  stock if  the above  described (or  other applicable)
holding periods respecting those shares have not been satisfied. If the  holding
periods  with respect to the statutory option stock are satisfied, or the shares
were not  acquired under  a statutory  stock  option of  the Company,  then  any
appreciation  in value of the surrendered  shares is not taxable upon surrender.
Special basis and  holding period rules  apply where previously  owned stock  is
used to exercise an ISO.

NONQUALIFIED STOCK OPTIONS

    AWARD;  EXERCISE.   An  optionee is  not taxable  upon the  award of  a NQO.
Federal income  tax consequences  upon  exercise will  depend upon  whether  the
shares  thereby acquired are  subject to a "substantial  risk of forfeiture." If
the shares are NOT subject to a  substantial risk of forfeiture, or if they  are
so restricted and the optionee files an election under Section 83(b) of the Code
("Section  83(b) Election") with  respect to the shares,  the optionee will have
ordinary income at the  time of exercise  measured by the  Option Spread on  the
exercise  date. The optionee's tax  basis in the shares  will be the fair market
value of the shares on the date of exercise, and the holding period for purposes
of determining whether  capital gain or  loss upon sale  is long- or  short-term
also will begin on that date. If the shares are subject to a substantial risk of
forfeiture  and no  Section 83(b)  Election is filed,  the optionee  will not be
taxable upon exercise, but  instead will have ordinary  income, on the date  the
restrictions lapse, in an amount equal to the difference between the amount paid
for  the shares  under the NQO  and their  fair market value  as of  the date of
lapse; in addition,  the optionee's  holding period will  begin on  the date  of
lapse.

    Whether  or not the shares are subject  to a substantial risk of forfeiture,
the amount of ordinary income taxable to an optionee who was an employee at  the
time  of grant constitutes "supplemental wages" subject to withholding of income
and employment taxes by  the Company, and the  Company receives a  corresponding
income tax deduction.

    SALE  OF OPTION  SHARES.  Upon  sale, other  than to the  Company, of shares
acquired under a NQO, an optionee generally will recognize capital gain or  loss
to  the extent of the  difference between the sale  price and the optionee's tax
basis in the  shares, which will  be long-term  gain or loss  if the  employee's
holding  period in the  shares is more  than one year.  If stock is  sold to the
Company rather than to a third party,  the sale may not produce capital gain  or
loss.  A sale  of shares  to the  Company will  constitute a  redemption of such
shares, which  could be  taxable as  a dividend  unless the  redemption is  "not
essentially equivalent to a dividend" within the meaning of the Code.

    EXERCISE WITH STOCK.  If an optionee tenders Common Stock to pay all or part
of  the exercise price  of a NQO, the  optionee will not have  a taxable gain or
deductible loss  on  the  surrendered  shares.  Instead,  shares  acquired  upon
exercise  that  are  equal in  value  to the  fair  market value  of  the shares

                                       25
<PAGE>
surrendered in  payment are  treated as  if they  had been  substituted for  the
surrendered  shares,  taking as  their basis  and holding  period the  basis and
holding period that the optionee had  in the surrendered shares. The  additional
shares are treated as newly acquired with a zero basis.

    If  the surrendered  shares are  statutory option  stock as  described above
under "Incentive Stock Options",  with respect to  which the applicable  holding
period  requirements for favorable  income tax treatment  have not expired, then
the newly acquired  shares substituted  for the statutory  option shares  should
remain subject to the federal income tax rules governing the surrendered shares,
but  the  surrender should  not constitute  a  Disqualifying Disposition  of the
surrendered stock.

PURCHASE PLAN

    In general, participants  will not  have taxable  income or  loss under  the
Purchase  Plan until they sell or otherwise dispose of shares acquired under the
Purchase Plan (or die holding  such shares). If the shares  are held, as of  the
date  of sale  or disposition,  for longer  than both:  (i) two  years after the
beginning of the enrollment period during  which the shares were purchased;  and
(ii)  one  year following  purchase, a  participant  will have  taxable ordinary
income equal to 15% of the fair market  value of the shares on the first day  of
the  enrollment  period  (but  not in  excess  of  the gain  on  the  sale). Any
additional gain from the sale will be long-term capital gain. The Company is not
entitled to an income tax deduction if the holding periods are satisfied.

    If the shares are disposed of before the expiration of both of the foregoing
holding periods (a "disqualifying disposition"), a participant will have taxable
ordinary income equal to the  excess of the fair market  value of the shares  on
the  purchase date  over the purchase  price. In addition,  the participant will
have taxable capital gain (or loss) measured by the difference between the  sale
price  and the participant's  purchase price plus the  amount of ordinary income
recognized, which gain (or loss) will be long-term if the shares have been  held
as  of the date of  sale for more than  one year. The Company  is entitled to an
income tax deduction  equal to  the amount of  ordinary income  recognized by  a
participant in a disqualifying disposition.

    Special rules apply to participants who are directors or officers.

SPECIAL FEDERAL INCOME TAX CONSIDERATION DUE TO SHORT SWING PROFIT RULE

    The  potential liability of a  person subject to Section  16 of the Exchange
Act to repay  short-swing profits  from the resale  of shares  acquired under  a
Company  plan constitutes a "substantial risk  of forfeiture" within the meaning
of the above-described rules, which is generally treated as lapsing at such time
as the potential liability under Section  16 lapses. Persons subject to  Section
16  who would  be required  by Section  16 to  repay profits  from the immediate
resale of stock acquired under a Company plan should consider whether to file  a
Section  83(b) Election at the  time they acquire stock  under a Company plan in
order to avoid deferral of the date  that they are deemed to acquire shares  for
federal income tax purposes.

                              INDEPENDENT AUDITORS

    The  Board  has  selected  the  accounting firm  of  Ernst  &  Young  LLP as
independent auditors to audit  the financial statements of  SEQUUS for the  year
ending  December 31, 1995. Ernst  & Young LLP has  been engaged as the Company's
auditors since 1983  and has  audited the  financial statements  of the  Company
since  inception. A representative of  Ernst & Young LLP  will be present at the
Annual Meeting,  will have  an opportunity  to make  a statement  if he  or  she
desires to do so and will be available to respond to appropriate questions.

                               OTHER INFORMATION

    A copy of the Company's Annual Report on Form 10-K for the fiscal year ended
December  31, 1994, as amended,  may be obtained, without  charge, by writing to
Secretary,  SEQUUS  Pharmaceuticals,  Inc.,  960  Hamilton  Court,  Menlo  Park,
California 94025.

                                       26
<PAGE>
                             STOCKHOLDER PROPOSALS

    The  Company  will  include in  proxy  statements of  the  Board stockholder
proposals complying with  the applicable  rules of the  Securities and  Exchange
Commission  and  any  applicable  state  laws. In  order  for  a  proposal  by a
stockholder to be included in the proxy  statement of the Board relating to  the
annual  meeting of stockholders to be held  in the Spring of 1996, that proposal
must be received in  writing by the  Secretary of the  Company at the  Company's
principal executive offices no later than February 15, 1996.

                                 OTHER MATTERS

    The  Board knows of no  other matters which will  be presented to the Annual
Meeting. If,  however, any  other matter  is properly  presented at  the  Annual
Meeting, the proxy solicited by this Proxy Statement will be voted in accordance
with the judgment of the person or persons holding such proxy.

                                          By Order of the Board of Directors,

   
                                          [sig]
                                          Sally A. Davenport,
    
                                          SECRETARY

Menlo Park, California
   
August 9, 1995
    

YOU  ARE CORDIALLY INVITED TO  ATTEND THE MEETING IN  PERSON. WHETHER OR NOT YOU
PLAN  TO  ATTEND  THE  MEETING,  YOU  ARE  REQUESTED  TO  SIGN  AND  RETURN  THE
ACCOMPANYING PROXY IN THE ENCLOSED POSTPAID ENVELOPE.

                                       27
<PAGE>
                                                                       EXHIBIT I

                          CERTIFICATE OF AMENDMENT OF
                          CERTIFICATE OF INCORPORATION
                        OF SEQUUS PHARMACEUTICALS, INC.

    It is hereby certified that:

        1.   The  name of the  Corporation in SEQUUS  Pharmaceuticals, Inc. (the
    "Corporation").

        2.   The  Certificate of  Incorporation  of the  Corporation  is  hereby
    amended  by striking out the first sentence  of Section 4 of the Certificate
    of Incorporation and substituting in lieu of said sentence the following new
    sentence:

            "The total number of  shares of all classes  of capital stock  which
    the  corporation  shall  have  authority  to  issue  is  Forty-Nine  Million
    (49,000,000) shares comprised of  Forty-Five Million (45,000,000) shares  of
    Common  Stock with a par value of One One-Hundredth of One Cent ($.0001) per
    share (the "Common Shares") and Four Million (4,000,000) shares of Preferred
    Stock with  a  par  value of  One  Cent  ($.01) per  share  (the  "Preferred
    Shares")."

        3.   This Certificate  of Amendment of  Certificate of Incorporation was
    duly adopted in accordance with the applicable provisions of Section 242  of
    the General Corporation Law of the State of Delaware.
    IN WITNESS WHEREOF, SEQUUS Pharmaceuticals, Inc. has caused this certificate
to be signed by its officer duly authorized, this     day of          , 1995.

                                          SEQUUS PHARMACEUTICALS, INC.

                                          By: __________________________________
                                             I. Craig Henderson
                                             CHAIRMAN OF THE BOARD
                                             AND CHIEF EXECUTIVE OFFICER
<PAGE>

                                          /X/ PLEASE MARK YOUR CHOICES LIKE THIS


             ----------        -------------------
               Common               Preferred

--------------------------------------------------------------------------------
           THE BOARD RECOMMENDS A VOTE "FOR" THE FOLLOWING PROPOSALS.
--------------------------------------------------------------------------------

                                             FOR ALL   WITHHOLD FOR ALL

Proposal 1.  To elect as directors
             Robert G. Faris,
             I. Craig Henderson, L.
             Scott Minick, Richard             / /            / /
             C.E. Morgan and E.
             Donnall Thomas.

INSTRUCTION: To withhold authority to
             vote for any individual
             nominee, write that
             nominee's name on the
             line provided below:

             ------------------------


                                             FOR       AGAINST        ABSTAIN

Proposal 2.  To approve the proposed
             Certificate of
             Amendment of the                / /          / /            / /
             Company's Certificate of
             Incorporation

Proposal 3.  To approve the proposed
             amendments to the 1987          / /          / /            / /
             Company's Employee Stock
             Option Plan.

Proposal 4.  To approve the proposed
             amendment to the
             Company's 1987                  / /          / /            / /
             Consultant Stock Option
             Plan.

Proposal 5.  To approve the proposed
             amendment to the
             Company's 1990 Director         / /          / /            / /
             Stock Oprion Plan.

Proposal 6.  To approve the proposed
             amendment to the                / /          / /            / /
             Company's Employee Stock
             Purchase Plan.


Signature(s)                                               Date,            1995
            ----------------------------------------------       ----------
Please date and sign exactly as name(s) appear(s) hereon. If shares are held
jointly, each holder should sign. Please give full title and capacity in which
signing if not signing as an individual.

<PAGE>

                                      PROXY
                           SEQUUS PHARMACEUTICALS, INC.

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
   
     The undersigned hereby appoint(s) I. CRAIG HENDERSON, M.D., ROBERT G. FARIS
AND SALLY A. DAVENPORT, or any of them, each with full power of substitution, as
the lawful attorneys and proxies of the undersigned to vote as designated below,
and in their discretion, upon such other business as may properly be presented
to the meeting, all of the shares of SEQUUS PHARMACEUTICALS, INC. (the
"Company") which the undersigned shall be entitled to vote at the Annual Meeting
of Stockholders to be held on September 12, 1995 at the offices of the Company
at 960 Hamilton Court, Menlo Park, California, and at any adjournments or
postponements thereof.
    
     This proxy, when properly executed, will be voted in the manner directed by
the undersigned stockholder. WHEN NO CHOICE IS INDICATED, THIS PROXY WILL BE
VOTED FOR THE NOMINEES AND THE PROPOSALS LISTED ON THE REVERSE. This proxy may
be revoked at any time prior to the time it is voted by any means described in
the accompanying Proxy Statement.

                  PLEASE COMPLETE, DATE AND SIGN THIS PROXY AND
                  RETURN IT PROMPTLY IN THE ENCLOSED ENVELOPE.



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission