HOUSTON BIOTECHNOLOGY INC
15-12B, 1997-03-03
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                      SECURITIES AND EXCHANGE COMMISSION

                            Washington, D.C. 20549

                                    FORM 15

Certification and Notice of Termination of Registration under Section 12(g) of
the Securities Exchange Act of 1934 or Suspension of Duty to File Reports Under
Sections 13 and 15(d) of the Securities Exchange Act of 1934.

                                                 Commission File Number: 1-12210
                                                                         -------

                      HOUSTON BIOTECHNOLOGY INCORPORATED
- - --------------------------------------------------------------------------------
            (Exact name of registrant as specified in its charter)

            3608 Research Forest Drive, The Woodlands, Texas 77381
- - --------------------------------------------------------------------------------
   (Address, including zip code, and telephone number, including area code,
                 of registrant's principal executive offices)

        Common Stock, par value $.01, Warrants to Purchase Common Stock
- - --------------------------------------------------------------------------------
           (Title of each class of securities covered by this Form)

                                     NONE
- - --------------------------------------------------------------------------------
  (Titles of all other classes of securities for which a duty to file reports
                     under section 13(a) or 15(d) remains)

        Please place an X in the box(es) to designate the appropriate rule
provision(s) relied upon to terminate or suspend the duty to file reports:

<TABLE>
          <S>                                       <C> 
           Rule 12g-4(a)(1)(i) [X]                  Rule 12h-3(b)(1)(ii) [_]
          Rule 12g-4(a)(1)(ii) [_]                   Rule 12h-3(b)(2)(i) [_]
           Rule 12g-4(a)(2)(i) [_]                  Rule 12h-3(b)(2)(ii) [_]
          Rule 12g-4(a)(2)(ii) [_]                            Rule 15d-6 [_]
           Rule 12h-3(b)(1)(i) [_]                     
</TABLE>
        
        Approximate number of holders of record as of the certification or
notice date:

1,167 for Common Stock; 1,202 for Warrants
- - ----------------------------------------------------------

        Pursuant to the requirements of the Securities Exchange Act of 1934
Houston Biotechnology Incorporated has caused this certification/notice to be
signed on its behalf by the undersigned duly authorized person.

                                              /s/ Donald L. Drakeman
DATE: March 3, 1997                        BY:________________________________
     ---------------                            Donald L. Drakeman - President


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