ENDOREX CORP
SC 13D/A, 1997-10-30
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D
                                (Amendment No. 4)

                    Under the Securities Exchange Act of 1934


              Endorex Corporation (f/k/a ImmunoTherapeutics, Inc.)
                                (Name of Issuer)


                     Common Stock, par value $.001 per share
                         (Title of Class of Securities)

                                   452916 40 6
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:

                              David R. Walner, Esq.
                    Paramount Capital Asset Management, Inc.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4372
       (Name, Address and Telephone Number of Person Authorized to Receive
                           Notices and Communications)



                                October 16, 1997
             (Date of Event which Requires Filing of this Statement)





                                        1

<PAGE>

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:
                                                                        [ ]

Check the following box if a fee is being paid with this Statement:
                                                                        [ ]


                                        2

<PAGE>


CUSIP No. [452916406]                  13 D                  Page 3 of  13 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP     (a)     [ ]

                                                              (b)     [ ]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) OR 2(e)
                                                                       [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                               7)     SOLE VOTING POWER
                                      None
         NUMBER                -------------------------------------------------
         OF                    8)     SHARED VOTING POWER
         SHARES                       2,376,720
         BENEFICIALLY          -------------------------------------------------
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         None
         REPORTING             -------------------------------------------------
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         2,376,720

- --------------------------------------------------------------------------------
11)       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
         PERSON

         2,376,720
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES                                                    [ ]

- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         24.2%

- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON
         CO
- --------------------------------------------------------------------------------


                                       3

<PAGE>


CUSIP No. [452916406]                  13 D                  Page 4 of  13 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP     (a)     [ ]

                                                              (b)     [ ]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) OR 2(e)
                                                                       [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                               7)     SOLE VOTING POWER
                                      None
         NUMBER                -------------------------------------------------
         OF                    8)     SHARED VOTING POWER
         SHARES                       745,899
         BENEFICIALLY          -------------------------------------------------
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         None
         REPORTING             -------------------------------------------------
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         745,899

- --------------------------------------------------------------------------------
11)       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
         PERSON

         745,899
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES                                                    [ ]

- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         7.6%

- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON
         PN
- --------------------------------------------------------------------------------


                                       4
<PAGE>


CUSIP No. [452916406]                  13 D                  Page 5 of  13 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         The Aries Fund, A Cayman Island Trust
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP     (a)     [ ]

                                                              (b)     [ ]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) OR 2(e)
                                                                       [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Cayman Islands
- --------------------------------------------------------------------------------
                               7)     SOLE VOTING POWER
                                      None
         NUMBER                -------------------------------------------------
         OF                    8)     SHARED VOTING POWER
         SHARES                       1,630,821
         BENEFICIALLY          -------------------------------------------------
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         None
         REPORTING             -------------------------------------------------
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         1,630,821

- --------------------------------------------------------------------------------
11)       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
         PERSON

         1,630,821
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES                                                    [ ]

- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         16.6%

- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON
         OO (see Item 2)
- --------------------------------------------------------------------------------


                                       5

<PAGE>


CUSIP No. [452916406]                  13 D                  Page 6 of  13 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP     (a)     [ ]

                                                              (b)     [ ]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) OR 2(e)
                                                                       [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
                               7)     SOLE VOTING POWER
                                      None
         NUMBER                -------------------------------------------------
         OF                    8)     SHARED VOTING POWER
         SHARES                       2,376,720
         BENEFICIALLY          -------------------------------------------------
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         None
         REPORTING             -------------------------------------------------
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         2,376,720

- --------------------------------------------------------------------------------
11)       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
         PERSON

         2,376,720
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES                                                    [ ]

- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         24.2%

- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON
         IN
- --------------------------------------------------------------------------------


                                       6

<PAGE>

Item 1.  Security and Issuer.

     (a)  Common Stock, $.001 par value ("Shares")

          Endorex  Corporation (f/k/a  ImmunoTherapeutics,  Inc.) (the "Issuer")
          900 North Shore Blvd. Lake Bluff, IL 60044 (847) 604-7555

Item 2.  Identity and Background.

          Names of Persons Filing:

     (a)  This  statement  is  filed  on  behalf  of  Paramount   Capital  Asset
          Management,  Inc.  ("Paramount  Capital "), Aries Domestic Fund,  L.P.
          ("Aries  Domestic"),  The Aries Fund, A Cayman  Island  Trust  ("Aries
          Trust") and Lindsay A. Rosenwald, M.D. ("Dr. Rosenwald")(collectively,
          "Reporting Parties").  See attached Exhibit A which is a copy of their
          agreement in writing to file this statement on behalf of each of them.

     (b)  The business  address of  Paramount  Capital,  Aries  Domestic and Dr.
          Rosenwald  is 787  Seventh  Avenue,  New York,  New York,  10019.  The
          business address for Aries Trust is c/o MeesPierson  (Cayman) Limited,
          P.O.  Box 2003,  British  American  Centre,  Phase 3, Dr. Roy's Drive,
          George Town, Grand Cayman.

     (c)  Dr.  Rosenwald is an investment  banker,  venture  capitalist and fund
          manager  and  is  the  sole  shareholder  of  Paramount   Capital,1  a
          Subchapter S corporation  incorporated in Delaware.  Paramount Capital
          is the  General  Partner  of Aries  Domestic,2  a limited  partnership
          incorporated  in  Delaware  and is the  Investment  Manager  to  Aries
          Trust,3 a Cayman Islands Trust.

     (d)  Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Trust and
          their respective  officers,  directors,  general partners,  investment
          managers,  or  trustees  have not,  during the five years prior to the
          date  hereof,  been con  victed in a  criminal  proceeding  (excluding
          traffic violations or similar misdemeanors).

     (e)  Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Trust and
          their respective  officers,  directors,  general partners,  investment
          managers,  or trustees  have not been,  during the five years prior to
          the date  hereof,  parties  to a civil  proceeding  of a  judicial  or
          administrative  body of competent juris diction,  as a result of which
          such  person was or is subject to a  judgment,  decree or final  order
          enjoining   future   violations  of,  or  prohibiting  or  mandat  ing
          activities subject to, Federal or State securities laws or finding any
          violation with respect to such laws.

                                       7


<PAGE>

     (f)  Dr. Rosenwald is a citizen of the United States.

Item 3.  Source and Amount of Funds or Other Consideration.

          Since  the  date of  Amendment  No.  3 to the  Original  Statement  on
          Schedule  13-D  ("Amendment  No.  3"),  filed on August 7, 1997,  in a
          private  placement of the 8,648,649  shares of common stock, par value
          $.001 per share,  of the Issuer  (the  "Private  Placement")  in which
          Paramount Capital, Inc. acted as Placement Agent, on October 16, 1997,
          Aries Domestic used its general funds to purchase, net of commissions,
          271,278 shares of Common Stock of the Issuer with attached contractual
          rights for an aggregate purchase price of $545,777 and the Aries Trust
          used its general funds to purchase, net of commissions, 550,776 shares
          of Common Stock of the Issuer with attached  contractual rights for an
          aggregate purchase price of $1,108,093.  The Private Placement had the
          net effect of  diluting  the  Reporting  Parties'  respective  percent
          interests.

Item 4.  Purpose of Transaction.

          The Reporting Parties acquired shares of Common Stock of the Issuer as
          an investment in the Issuer.

          Although the  Reporting  Parties have not  formulated  any  definitive
          plans, they may from time to time acquire, or dispose of, Common Stock
          and/or  other  securities  of the  Issuer  if and  when  they  deem it
          appropriate. The Reporting Parties may formulate other purposes, plans
          or proposals  relating to any of such  securities of the Issuer to the
          extent  deemed  advisable  in light of market  conditions,  investment
          policies and other factors.

          Except as  indicated  in this  Schedule  13D,  the  Reporting  Parties
          currently have no plans or proposals that relate to or would result in
          any of the matters  described in subparagraphs (a) through (j) of Item
          4 of Schedule 13D.

Item 5.  Interest in Securities of the Issuer.

     (a)  As of October 16, 1997, Dr. Rosenwald and Paramount  Capital,  through
          acquisition  of the  shares  by the Aries  Trust  and Aries  Domestic,
          benefi  cially  owned  2,376,720  shares  or  24.2%  of  the  Issuer's
          securities and Aries Domestic and the Aries Trust  beneficially  owned
          as follows:

                                                         Amount Owned
                                                         ------------
             Aries Domestic                                745,899 Shares
             Aries Trust                                 1,630,821 Shares

     (b)  Dr.  Rosenwald  and  Paramount  Capital  share the power to vote or to
          direct the vote,  to dispose  or to direct  the  disposition  of those
          shares owned by each of Aries Domestic and Aries Trust.

     (c)  Other than as set forth in Item 3 above,  no open market  transactions
          were made by Aries Domestic and the Aries Trust in the past 60 days.

- -------------------

1    Please  see  attached  Exhibit B  indicating  the  executive  officers  and
     directors  of Paramount  Capital and  providing  information  called for by
     Items 2-6 of this statement as to said officers and directors. Exhibit B is
     herein incorporated by reference.
2    Please see  attached  Exhibit C  indicating  the  general  partner of Aries
     Domestic and the general  partner's  executive  officers and  directors and
     providing  information called for by Items 2-6 of this statement as to said
     general partners, officers and directors.  Exhibit C is herein incorporated
     by reference.
3    Please see attached  Exhibit D  indicating  the  investment  manager of the
     Aries Trust and the investment  manager's executive officers and direc tors
     and providing  information  called for by Items 2-6 of this statement as to
     said  investment  manager and officers and  directors.  Exhibit D is herein
     incorporated by reference.


                                       8

<PAGE>

          Other than as set forth herein the Reporting  Parties have not engaged
          in any  transactions in the Common Stock of the Issuer during the past
          60 days.

(d)  & (e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with respect to
Securities of the Issuer

          Paramount Capital is the Investment Manager of the Aries Trust and the
          General  Partner  of Aries  Domestic  and in such  capacities  has the
          authority  to make  certain  investment  decisions  on  behalf of such
          entities,  including  decisions  relating  to  the  securities  of the
          Issuer. In connection with its investment management duties, Paramount
          Capital receives certain  management fees and performance  allocations
          from the Aries Trust and Aries Domestic.

          Dr.  Rosenwald  is the  President  and sole  shareholder  of Paramount
          Capital. Mr. Steve Kanzer, a Senior Managing Director of the Placement
          Agent (as defined below),  joined the Board of Directors of the Issuer
          in connection  with the initial  investment by Aries  Domestic and the
          Aries Trust in June 1996 and receives compensation for such services.

          Pursuant to Article 6 of the  Subscription  Agreement  executed by the
          Issuer and each  investor  in the  Private  Placement,  the  Reporting
          Parties are entitled to  contractual  rights (the "Article VI Rights")
          attached  to the  shares  of  Common  Stock  acquired  in the  Private
          Placement.  The Article VI Rights provide for additional  issuances of
          Common Stock to the Reporting  Persons upon the occurrence of dilution
          events,  such as issuances of Common Stock (or securities  convertible
          into, or exercisable for, Common Stock) at a price per share less than
          the then current  market price or the  then-effective  price per share
          paid by purchasers in the Private  Placement,  to compensate  for such
          dilution.  The Article VI Rights also provide for additional issuances
          of Common Stock on each six month anniversary of the first anniversary
          of the  final  closing  of the  Private  Placement.  Furthermore,  the
          Article  VI Rights  include a right to put the  Common  Stock to which
          they  relate  to the  Issuer  for 130% of the  purchase  price of such
          shares in the Private Placement.  The Reporting Persons,  however have
          covenanted only to exercise such put under certain circumstances.

          Paramount Capital, Inc., (the "Placement Agent") an NASD member broker
          dealer and an  affiliate  of Aries  Domestic  and the Aries  Trust has
          acted as Placement Agent for the Issuer. and will receive certain fees
          for such services  including  warrants (the  "Placement  Warrants") to
          purchase  864,865  shares of Common  Stock with  attached  contractual
          rights at an exercise  price equal to  $2.54375.  On October 16, 1997,
          the Issuer and the Placement  Agent  entered into a  twenty-four  (24)
          month engagement  agreement,  pursuant to which the Placement Agent is
          entitled  to receive a cash  retainer  and  standard  success  fees in
          addition to warrants (the "Advisory  Warrants")to  purchase  1,297,297
          shares of Common Stock with attached contractual rights at an exercise
          price equal to $2.54375.  The  Placement  and Advisory  Warrants  will
          become exercisable on April 16, 1997.

          Except as  indicated in this 13D and  exhibits,  there is no contract,
          arrangement,  understanding  or  relationship  between  the  Reporting
          Parties and any other  person,  with respect to any  securities of the
          Issuer.




                                       9


<PAGE>

                                   SIGNATURES


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   October 26, 1997
         New York, NY             By /s/Lindsay A. Rosenwald, M.D.
                                    ------------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


                                   ARIES DOMESTIC FUND, L.P.
                                   By Paramount Capital Asset Management, Inc.
                                   General Partner

Dated:   October 26, 1997
         New York, NY              By /s/Lindsay A. Rosenwald, M.D.
                                    ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      President


                                   THE ARIES TRUST
                                   By Paramount Capital Asset Management, Inc.
                                   Investment Manager

Dated:   October 26, 1997
         New York, NY              By /s/Lindsay A. Rosenwald, M.D.
                                    ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      President


Dated:   October 26, 1997
         New York, NY              By /s/Lindsay A. Rosenwald, M.D.
                                    ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.


                                       10



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