ENDOREX CORP
SC 13D/A, 1999-05-05
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D
                                (Amendment No. 5)

                    Under the Securities Exchange Act of 1934


              Endorex Corporation (f/k/a ImmunoTherapeutics, Inc.)
                                (Name of Issuer)


                     Common Stock, par value $.001 per share
                         (Title of Class of Securities)

                                   452916 40 6
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

   (Name, Address and Telephone Number of Person Authorized to Receive Notices
                               and Communications)



                                 March 31, 1998
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule  13D and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following: [ ]





<PAGE>

                                  SCHEDULE 13D
CUSIP No. [452916406]                                         Page 2 of 14 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                        None
  NUMBER OF         
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY             2,667,511
EACH REPORTING      
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        2,667,511
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         2,667,511
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                 [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         26.1%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         CO
- --------------------------------------------------------------------------------

                                       2

<PAGE>

                                  SCHEDULE 13D
CUSIP No. [452916406]                                         Page 3 of 14 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                        None
  NUMBER OF         
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY             838,971
EACH REPORTING      
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        838,971
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         838,971
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                 [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         8.3%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------

                                        3


<PAGE>


                                  SCHEDULE 13D
CUSIP No. [452916406]                                         Page 4 of 14 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    The Aries Master Fund, A Cayman Island Exempted Company
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                        None
  NUMBER OF         
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY             1,828,940
EACH REPORTING      
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        1,828,940
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         1,828,940
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                 [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         18.0%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         OO (see Item 2)
- --------------------------------------------------------------------------------

                                        4


<PAGE>
                                  SCHEDULE 13D
CUSIP No. [452916406]                                         Page 5 of 14 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                        1,434,033
  NUMBER OF         
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY             2,667,511
EACH REPORTING      
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        1,434,033
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        2,667,511
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         4,101,544
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                 [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         35.2%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------

                                        5

<PAGE>


Item 1.  Security and Issuer.

     (a)  Common Stock, $.001 par value ("Shares")

          Endorex Corporation (f/k/a ImmunoTherapeutics, Inc.) (the "Issuer")
          900 North Shore Blvd.
          Lake Bluff, IL 60044
          (847) 604-7555

Item 2.  Identity and Background.

     Names of Persons Filing:

     (a)  This  statement  is  filed  on  behalf  of  Paramount   Capital  Asset
          Management,  Inc.  ("Paramount  Capital"),  Aries Domestic Fund,  L.P.
          ("Aries  Domestic"),  Aries  Master  Fund,  a Cayman  Island  exempted
          company ("Aries Fund") and Lindsay A. Rosenwald, M.D. ("Dr. Rosenwald"
          and collectively,  "Reporting Parties").  See attached Exhibit A which
          is a copy of their  agreement  in  writing to file this  statement  on
          behalf of each of them.

     (b)  Paramount  Capital's,  Aries Domestic's and Dr.  Rosenwald's  business
          address is 787 Seventh Avenue,  48th Floor, New York, New York, 10019.
          The  business  address  for  Aries  Fund is c/o  MeesPierson  (Cayman)
          Limited,  P.O. Box 2003,  British American Centre,  Phase 3, Dr. Roy's
          Drive, George Town, Grand Cayman.

     (c)  Dr.  Rosenwald  is an  investment  banker,  venture  capitalist,  fund
          manager and sole  shareholder  of  Paramount  Capital,1 a Subchapter S
          corporation incorporated in Delaware. Paramount Capital is the General
          Partner of Aries  Domestic,2  a limited  partnership  incorporated  in
          Delaware.  Paramount Capital is the Investment Manager to Aries Fund,3
          a Cayman Islands exempted company.

     (d)  Dr. Rosenwald,  Paramount  Capital,  Aries Domestic and Aries Fund and
          their respective  officers,  directors,  general partners,  investment
          managers,  or  trustees  have not,  during the five years prior to the
          date  hereof,  been  convicted  in a  criminal  proceeding  (excluding
          traffic violations or similar misdemeanors).

     (e)  Dr. Rosenwald,  Paramount  Capital,  Aries Domestic and Aries Fund and
          their respective  officers,  directors,  general partners,  investment
          managers,  or trustees  have not been,  during the five years prior to
          the date  hereof,  parties  to a civil  proceeding  of a  judicial  or
          administrative  body of competent  jurisdiction,  as a result of which
          such  person was or is subject to a  judgment,  decree or final  order
          enjoining future violations of, or prohibiting or mandating activities
          subject to, Federal or State  securities laws or finding any violation
          with respect to such laws.

     (f)  Dr. Rosenwald is a citizen of the United States.

Item 3.  Source and Amount of Funds or Other Consideration.

     Since the date of  Amendment  No. 4 to the  Original  Statement on Schedule
     13-D  ("Amendment  No. 4"), filed on October 16, 1997,  Aries Domestic used
     its general funds to purchase an aggregate of 46,626 shares of Common Stock
     of the Issuer in the open market and the Aries Fund used its general  funds
     to purchase an aggregate of 46,626 shares

- --------
1    Please  see  attached  Exhibit B  indicating  the  executive  officers  and
     directors  of Paramount  Capital and  providing  information  called for by
     Items 2-6 of this statement as to said officers and directors. Exhibit B is
     herein incorporated by reference.

2    Please see  attached  Exhibit C  indicating  the  general  partner of Aries
     Domestic and the general  partner's  executive  officers and  directors and
     providing  information called for by Items 2-6 of this statement as to said
     general partners, officers and directors.  Exhibit C is herein incorporated
     by reference.

3    Please see attached  Exhibit D  indicating  the  investment  manager of the
     Aries Fund and the investment  manager's  executive  officers and directors
     and providing  information  called for by Items 2-6 of this statement as to
     said  investment  manager and officers and  directors.  Exhibit D is herein
     incorporated by reference.


                                        6

<PAGE>

     of Common Stock of the Issuer in the open market.  In  connection  with its
     investment  in a private  placement  of the Issuer on October 16, 1997 (the
     "Private  Placement"),  Aries Domestic was allocated  warrants  ("Placement
     Warrants") to purchase 56,533 Shares of the Issuer from Paramount  Capital,
     Inc.,  which  conducted the Private  Placement and Aries Fund was allocated
     Placement  Warrants to purchase 112,159 Shares of the Issuer from Paramount
     Capital,  Inc. Lindsay A. Rosenwald,  M.D.,  chairman of Paramount Capital,
     Inc. was allocated  Placement  Warrants to purchase  292,411  Shares of the
     Issuer from Paramount Capital, Inc. Further, in connection with the Private
     Placement,  Paramount Capital, Inc. and the Issuer entered into an advisory
     agreement oursuant to which it received a number of warrants (the "Advisory
     Warrants").  Dr.  Rosenwald  was  allocated  Advisory  Warrants to purchase
     1,141,622 Shares.  The Placement  Warrants and the Advisory Warrants vested
     and became  exercisable on April 16, 1998 at an intial exercise price equal
     to $2.54 per share  and will be  exercisable  until  April  16,  2003.  The
     exercise  price is  subject to  adjustment  upon the  occurence  of certain
     events.

Item 4.  Purpose of Transaction.

     The Reporting  Parties  acquired shares of Common Stock of the Issuer as an
     investment in the Issuer.

     Although the Reporting  Parties have not formulated  any definitive  plans,
     they may from time to time  acquire,  or dispose of,  Common  Stock  and/or
     other  securities of the Issuer if and when they deem it  appropriate.  The
     Reporting Parties may formulate other purposes, plans or proposals relating
     to any of such  securities of the Issuer to the extent deemed  advisable in
     light of market conditions, investment policies and other factors.

     Except as indicated in this Schedule 13D, the Reporting  Parties  currently
     have no plans or  proposals  that  relate to or would  result in any of the
     matters  described in  subparagraphs  (a) through (j) of Item 4 of Schedule
     13D.

Item 5.  Interest in Securities of the Issuer.

     (a)  As of April 21,  1999,  Dr.  Rosenwald  both  personally  and  through
          acquisition  of the  shares  by the  Aries  Fund and  Aries  Domestic,
          beneficially  owned  4,101,544,   Shares  or  35.2%  of  the  Issuer's
          securities and Paramount Capital  beneficially  owned 2,667,511 Shares
          or 26.1% of the Issuer's securities. Aries Domestic and the Aries Fund
          beneficially owned as follows:

                                                       Amount Owned
                                                       ------------
          Aries Domestic                                838,971 Shares
          Aries Fund                                  1,828,940 Shares

     (b)  Dr.  Rosenwald  and  Paramount  Capital  share the power to vote or to
          direct the vote,  to dispose  or to direct  the  disposition  of those
          shares owned by each of Aries Domestic and Aries Fund.

     (c)  The following  acquisitions of Shares of the Issuer were made by Aries
          Domestic in the past 60 days:

                   Date        No. Shares    Price Per Share
                   -----------------------------------------
                   03/11/99         500            $2.250
                   03/12/99         500            $2.000
                   03/15/99         600            $2.000
                   03/16/99         600            $1.938
                   03/17/99         600            $1.875
                   03/18/99         600            $1.750
                   03/19/99         600            $1.875
                   03/22/99         700            $1.875
                   03/23/99         700            $2.000
                   03/24/99         700            $2.000
                   03/25/99         700            $2.000
                   03/26/99         700            $2.000
                   03/29/99         700            $2.125
                   03/30/99         700            $2.125
                   03/31/99         2,440          $2.125
                   04/01/99         700            $2.125
                   04/05/99         800            $2.125

                                       7

<PAGE>


                   04/06/99         800           $2.125
                   04/07/99         800           $2.141
                   04/08/99         800           $2.141
                   04/09/99         800           $2.238
                   04/12/99         500           $2.125
                   04/13/99         500           $2.026
                   04/14/99         500           $2.000
                   04/15/99         500           $2.000
                   04/16/99         500           $2.000
                   04/19/99         300           $2.000
                   04/20/99         400           $2.000

     The  following  acquisitions  of  Shares of the  Issuer  were made by Aries
     Domestic in the past 60 days:

                   Date        No. Shares    Price Per Share 
                   ------------------------------------------
                   02/22/99         1700          $2.000
                   02/23/99         1,700         $2.000
                   02/24/99         1,700         $2.000
                   02/25/99         1,700         $2.000
                   02/26/99         1,700         $1.938
                   03/01/99         1,400         $1.875
                   03/02/99         1,700         $2.000
                   03/03/99         1,700         $2.250
                   03/04/99         1,700         $2.063
                   03/08/99         1,200         $1.876
                   03/09/99         1,200         $1.750
                   03/10/99         1,200         $2.103
                   03/11/99         1,200         $2.250
                   03/12/99         1,200         $2.000
                   03/15/99         1,600         $2.000
                   03/16/99         1,600         $1.938
                   03/17/99         1,600         $1.875
                   03/18/99         1,600         $1.750
                   03/19/99         1,600         $1.875
                   03/22/99         1,700         $1.875
                   03/23/99         1,700         $2.000
                   03/24/99         1,700         $2.000
                   03/25/99         1,700         $2.000
                   03/26/99         1,700         $2.000
                   03/29/99         1,800         $2.125
                   03/30/99         1,800         $2.125
                   03/31/99         60            $2.125
                   04/01/99         1,800         $2.125
                   04/05/99         1,900         $2.125
                   04/06/99         1,900         $2.125
                   04/07/99         1,900         $2.141
                   04/08/99         1,900         $2.141
                   04/09/99         1,900         $2.238
                   04/12/99         1,200         $2.125
                   04/13/99         1,200         $2.026
                   04/14/99         1,200         $2.000
                   04/15/99         1,200         $2.000
                   04/16/99         1,200         $2.000
                   04/19/99         950           $2.000
                   04/20/99         850           $2.000

                                       8

<PAGE>


     Other than as set forth  herein the  Reporting  Parties have not engaged in
     any transactions in the Common Stock of the Issuer during the past 60 days.

                  (d) & (e)         Not applicable.

Item 6.  Contracts, Arrangements, Understandings or Relationships
         with respect to Securities of the Issuer                

     Paramount  Capital  is the  Investment  Manager  of the Aries  Fund and the
     General  Partner of Aries Domestic and in such capacities has the authority
     to make certain investment decisions on behalf of such entities,  including
     decisions  relating to the securities of the Issuer. In connection with its
     investment management duties, Paramount Capital receives certain management
     fees and performance allocations from the Aries Fund and Aries Domestic.

     Dr. Rosenwald is the President and sole  shareholder of Paramount  Capital.
     Mr. Steve  Kanzer,  formerly a Senior  Managing  Director of the  Placement
     Agent (as defined  below),  joined the Board of  Directors of the Issuer in
     connection   with  the  initial   investment  by  Aries  Domestic  and  the
     predecessor in interest to the Aries Fund, the Aries Trust, a Cayman Island
     trust in June 1996 and receives compensation for such services.

     Pursuant to Article 6 of the Subscription  Agreement executed by the Issuer
     and each  investor  in the Private  Placement,  the  Reporting  Parties are
     entitled to the  contractual  rights (the "Article VI Rights")  attached to
     the shares of Common Stock  acquired in the Private  Placement as set forth
     in Exhibit A to Amendment No. 4.

     Paramount  Capital,  Inc.,  (the  "Placement  Agent") an NASD member broker
     dealer and an affiliate  of Aries  Domestic and the Aries Fund has acted as
     Placement  Agent for the  Issuer  and has  received  certain  fees for such
     services including warrants (the "Placement  Warrants") to purchase 864,865
     shares of Common  Stock with  attached  contractual  rights at an  exercise
     price equal to $2.54375.  On October 16, 1997, the Issuer and the Placement
     Agent entered into a twenty-four (24) month engagement agreement,  pursuant
     to which the  Placement  Agent is entitled to receive a cash  retainer  and
     standard success fees in addition to warrants (the "Advisory  Warrants") to
     purchase 1,297,297 shares of Common Stock with attached  contractual rights
     at an exercise price equal to $2.54375. The Placement and Advisory Warrants
     will become exercisable on April 16, 1997.

     Except  as  indicated  in this  13D and  exhibits,  there  is no  contract,
     arrangement,  understanding or relationship  between the Reporting  Parties
     and any other person, with respect to any securities of the Issuer.


Item 7.  Material to be Filed as Exhibits:

Exhibit A -       Copy of an  Agreement  between  Dr.  Rosenwald,  Paramount
                  Capital,  Aries Domestic and Aries Fund to file this Statement
                  on Schedule 13D on behalf of each of them.

Exhibit B -       List of executive officers and directors of Paramount Capital
                  and information called for by Items 2-6 of this statement
                  relating to said officers and directors.

Exhibit C -       List of executive officers and directors of Aries Domestic and
                  information called for by Items 2-6 of this statement relating
                  to said officers and directors.

Exhibit D -       List of executive officers and directors of Aries Fund and 
                  information called for by Items 2-6 of this statement relating
                  to said officers and directors.



                                       9
<PAGE>

                                   SIGNATURES


                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:       April 21, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                     ARIES DOMESTIC FUND, L.P.
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:       April 21, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                     THE ARIES FUND
                                     By Paramount Capital Asset Management, Inc.
                                        Investment Manager

Dated:       April 21, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                        Chairman


Dated:       April 21, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.


                                       10

<PAGE>



                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D



                  The undersigned hereby agrees to jointly prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each of the  undersigned's  ownership of securities of Endorex Corp.,
and hereby affirm that such Schedule 13D is being filed on behalf of each of the
undersigned.


                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:       April 21, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                     ARIES DOMESTIC FUND, L.P.
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:       April 21, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                     THE ARIES FUND
                                     By Paramount Capital Asset Management, Inc.
                                        Investment Manager

Dated:       April 21, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                        Chairman


Dated:       April 21, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.


                                       11

<PAGE>


                                    EXHIBIT B

         The name and principal occupation or employment, which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                                    PRINCIPAL OCCUPATION
         NAME                                          OR EMPLOYMENT

Lindsay A. Rosenwald, M.D.        Chairman  of the Board of  Paramount  Capital
                                  Asset  Management,  Inc.,  Paramount  Capital
                                  Investments, LLC and Paramount Capital, Inc. 

Mark C. Rogers, M.D.              President   of   Paramount    Capital   Asset
                                  Management,     Inc.,    Paramount    Capital
                                  Investments, LLC and Paramount Capital, Inc. 

Peter Morgan Kash                 Director   of   Paramount    Capital    Asset
                                  Management,  Inc., Senior Managing  Director,
                                  Paramount Capital, Inc.

Dr. Yuichi Iwaki                  Director   of   Paramount    Capital    Asset
                                  Management,  Inc., Professor,  Uni versity of
                                  Southern California School of Medicine       


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.

                                       12


<PAGE>



                                    EXHIBIT C

         The name and principal  occupation or  employment,  which is located at
787  Seventh  Avenue,  48th Floor,  New York,  New York,  10019,  of the General
Partner of Aries Domestic is as follows:

                                                     PRINCIPAL OCCUPATION
         NAME                                           OR EMPLOYMENT
         ----                                           -------------

Paramount Capital Asset Management, Inc.    General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.

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<PAGE>

                                    EXHIBIT D

         The name and principal occupation or employment, which in each instance
is with The Aries Master Fund ("Aries Fund") located at 787 Seventh Avenue, 48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                       PRINCIPAL OCCUPATION
         NAME                                             OR EMPLOYMENT

Paramount Capital Asset Management, Inc.               Investment Manager

MeesPierson (Cayman) Management Limited                Administrator

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years  prior to the date  hereof,  neither of the above
persons  (to the  best of Aries  Fund's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


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