ENDOREX CORP
SC 13D/A, 1999-11-05
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D
                                (Amendment No. 6)

                    Under the Securities Exchange Act of 1934

              Endorex Corporation (f/k/a ImmunoTherapeutics, Inc.)
              ----------------------------------------------------
                                (Name of Issuer)

                     Common Stock, par value $.001 per share
                     ---------------------------------------
                         (Title of Class of Securities)

                                   452916 40 6
                                   -----------
                                 (CUSIP Number)

                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300
                            -----------------------

(Name, Address and Telephone Number of Person Authorized to Receive Notices and
                                Communications)

                                  July 31, 1999
                                  -------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:
                                                                    [ ]

Check the following box if a fee is being paid with this Statement:
                                                                    [ ]

                                         1

<PAGE>

CUSIP No. [452916406]               13D                   Page 2 of 19 Pages

- --------------------------------------------------------------------------------
    1    NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
   2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP       (a) [ ]  (b) [ ]
- --------------------------------------------------------------------------------
   3     SEC USE ONLY
- --------------------------------------------------------------------------------
   4     SOURCE OF FUNDS* OO (see Item 3 below)
- --------------------------------------------------------------------------------
   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                       [ ]
- --------------------------------------------------------------------------------
   6     CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                                       7   SOLE VOTING POWER
                                           None
             NUMBER OF             ---------------------------------------------
              SHARES                   8   SHARED VOTING POWER
           BENEFICIALLY                    3,117,585
             OWNED BY              ---------------------------------------------
               EACH                    9   SOLE DISPOSITIVE POWER
             REPORTING                     None
              PERSON               ---------------------------------------------
               WITH                   10   SHARED DISPOSITIVE POWER
                                           3,117,585
- --------------------------------------------------------------------------------
   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         3,117,585
- --------------------------------------------------------------------------------
   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                       [ ]
- --------------------------------------------------------------------------------
   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         30.65%
- --------------------------------------------------------------------------------
   14    TYPE OF REPORTING PERSON*
         CO
- --------------------------------------------------------------------------------

<PAGE>

CUSIP No. [452916406]                13D                  Page 3 of 19 Pages

- --------------------------------------------------------------------------------
    1    NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                (a) [ ]  (b) [ ]
- --------------------------------------------------------------------------------
    3    SEC USE ONLY
- --------------------------------------------------------------------------------
    4 SOURCE OF FUNDS* OO (see Item 3 below)
- --------------------------------------------------------------------------------
   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                        [ ]
- --------------------------------------------------------------------------------
   6     CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                                       7    SOLE VOTING POWER
                                            None
             NUMBER OF             ---------------------------------------------
              SHARES                   8    SHARED VOTING POWER
           BENEFICIALLY                     973,398
             OWNED BY              ---------------------------------------------
               EACH                    9    SOLE DISPOSITIVE POWER
             REPORTING                      None
              PERSON               ---------------------------------------------
               WITH                   10    SHARED DISPOSITIVE POWER
                                            973,398
- --------------------------------------------------------------------------------
   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         973,398
- --------------------------------------------------------------------------------
   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                      [ ]
- --------------------------------------------------------------------------------
   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         9.72%
- --------------------------------------------------------------------------------
   14    TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------

<PAGE>

CUSIP No. [452916406]                   13D               Page 4 of 19 Pages

- --------------------------------------------------------------------------------
    1    NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aries Domestic Fund II, L.P.
- --------------------------------------------------------------------------------
   2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                               (a) [ ]   (b) [ ]
- --------------------------------------------------------------------------------
   3     SEC USE ONLY
- --------------------------------------------------------------------------------
   4     SOURCE OF FUNDS* OO (see Item 3 below)
- --------------------------------------------------------------------------------
   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                     [ ]
- --------------------------------------------------------------------------------
   6     CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                                       7    SOLE VOTING POWER
                                            None
             NUMBER OF               -------------------------------------------
              SHARES                   8    SHARED VOTING POWER
           BENEFICIALLY                     10,504
             OWNED BY                -------------------------------------------
               EACH                    9    SOLE DISPOSITIVE POWER
             REPORTING                      None
              PERSON                 -------------------------------------------
               WITH                   10    SHARED DISPOSITIVE POWER
                                            10,504
- --------------------------------------------------------------------------------
   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         10,504
- --------------------------------------------------------------------------------
   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                   [ ]
- --------------------------------------------------------------------------------
   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         0.1%
- --------------------------------------------------------------------------------
   14    TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------

<PAGE>

CUSIP No. [452916406]                 13D                 Page 5 of 19 Pages

- --------------------------------------------------------------------------------
    1   NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        The Aries Master Fund, A Cayman Island Exempted Company
- --------------------------------------------------------------------------------
    2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                (a) [ ]  (b) [ ]
- --------------------------------------------------------------------------------
   3    SEC USE ONLY

- --------------------------------------------------------------------------------
   4 SOURCE OF FUNDS* OO (see Item 3 below)
- --------------------------------------------------------------------------------
   5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
        ITEM 2(d) or 2(e)
                                                                   [ ]
- --------------------------------------------------------------------------------
   6    CITIZENSHIP OR PLACE OF ORGANIZATION
        Cayman Islands
- --------------------------------------------------------------------------------
                                       7    SOLE VOTING POWER
                                            None
             NUMBER OF               -------------------------------------------
              SHARES                   8    SHARED VOTING POWER
           BENEFICIALLY                     2,133,683
             OWNED BY                -------------------------------------------
               EACH                    9    SOLE DISPOSITIVE POWER
             REPORTING                      None
              PERSON                 -------------------------------------------
               WITH                   10    SHARED DISPOSITIVE POWER
                                            2,133,683
- --------------------------------------------------------------------------------
   11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        2,133,683
- --------------------------------------------------------------------------------
   12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                    [ ]
- --------------------------------------------------------------------------------
   13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        21.14%
- --------------------------------------------------------------------------------
   14 TYPE OF REPORTING PERSON* OO (see Item 2)
- --------------------------------------------------------------------------------

<PAGE>

CUSIP No. [452916406]                 13D               Page 6 of 19 Pages

- --------------------------------------------------------------------------------
    1    NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                             (a) [ ]  (b) [ ]
- --------------------------------------------------------------------------------
    3    SEC USE ONLY
- --------------------------------------------------------------------------------
    4    SOURCE OF FUNDS* OO (see Item 3 below)
- --------------------------------------------------------------------------------
   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                  [ ]
- --------------------------------------------------------------------------------
   6     CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
                                       7    SOLE VOTING POWER
                                            1,434,033
             NUMBER OF              --------------------------------------------
              SHARES                   8    SHARED VOTING POWER
           BENEFICIALLY                     3,117,505
             OWNED BY               --------------------------------------------
               EACH                    9    SOLE DISPOSITIVE POWER
             REPORTING                      1,434,033
              PERSON                --------------------------------------------
               WITH                   10    SHARED DISPOSITIVE POWER
                                            3,117,505
- --------------------------------------------------------------------------------
   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         4,551,538
- --------------------------------------------------------------------------------
   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                    [ ]
- --------------------------------------------------------------------------------
   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         39.22%
- --------------------------------------------------------------------------------
   14    TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------

<PAGE>
Item 1. Security and Issuer.

        (a)    Common Stock, $.001 par value ("Shares")

               Endorex   Corporation  (f/k/a   ImmunoTherapeutics,   Inc.)  (the
               "Issuer")  900 North  Shore  Blvd.  Lake  Bluff,  IL 60044  (847)
               604-7555

Item 2. Identity and Background.

        Names of Persons Filing:

        (a)    This  statement  is filed on behalf of  Paramount  Capital  Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
               ("Aries  Domestic"),  Aries Domestic Fund II, L.P.  ("Aries II"),
               Aries Master  Fund,  a Cayman  Island  exempted  company  ("Aries
               Fund") and  Lindsay  A.  Rosenwald,  M.D.  ("Dr.  Rosenwald"  and
               collectively,  "Reporting  Parties").  The Reporting Parties have
               made, and will continue to make, their own investment  decisions.
               See  attached  Exhibit  A which is a copy of their  agreement  in
               writing to file this statement on behalf of each of them.

        (b)    Paramount  Capital's,  Aries  Domestic's,   Aries  II's  and  Dr.
               Rosenwald's  business address is 787 Seventh Avenue,  48th Floor,
               New York, New York, 10019. The business address for Aries Fund is
               c/o MeesPierson (Cayman) Limited, P.O. Box 2003, British American
               Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

        (c)    Dr. Rosenwald is an investment banker,  venture capitalist,  fund
               manager  and  sole   shareholder   of  Paramount   Capital,(1)  a
               Subchapter S  corporation  incorporated  in  Delaware.  Paramount
               Capital is the General Partner of Aries Domestic, and Aries II(2)
               a limited partnership incorporated in Delaware. Paramount Capital
               is the  Investment  Manager to Aries  Fund,(3)  a Cayman  Islands
               exempted company.

        (d)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic,  Aries II and
               Aries  Fund and their  respective  officers,  directors,  general
               partners,  investment managers,  or trustees have not, during the
               five years prior to the date hereof, been convicted in a criminal
               proceeding    (excluding    traffic    violations    or   similar
               misdemeanors).

        (e)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic,  Aries II and
               Aries  Fund and their  respective  officers,  directors,  general
               partners,  investment managers, or trustees have not been, during
               the  five  years  prior to the date  hereof,  parties  to a civil
               proceeding  of a judicial  or  administrative  body of  competent
               jurisdiction,  as a result of which such person was or is subject
               to a judgment,  decree or final order enjoining future violations
               of, or prohibiting  or mandat ing activities  subject to, Federal
               or State securities laws or finding any violation with respect to
               such laws.

        (f)    Dr. Rosenwald is a citizen of the United States.


                                  Page 7 of 19

- ---------------
   1      Please see attached  Exhibit B indicating  the executive  officers and
          directors of Paramount Capital and providing information called for by
          Items 2-6 of this statement as to said officers and directors. Exhibit
          B is herein incorporated by reference.

   2      Please see attached  Exhibit C indicating the general partner of Aries
          Domestic and Aries II and the general partner's executive officers and
          directors  and providing  information  called for by Items 2-6 of this
          statement as to said general partners, officers and directors. Exhibit
          C is herein incorporated by reference.

   3      Please see attached Exhibit D indicating the investment manager of the
          Aries  Fund  and  the  investment  manager's  executive  officers  and
          directors  and providing  information  called for by Items 2-6 of this
          statement as to said  investment  manager and officers and  directors.
          Exhibit D is herein incorporated by reference.

<PAGE>

Item 3. Source and Amount of Funds or Other Consideration.

        Since the date of Amendment No. 5 to the Original  Statement on Schedule
        13-D  ("Amendment No. 5"), filed on April 22, 1999,  Aries Domestic used
        its general  funds to purchase an aggregate of 104,109  shares of Common
        Stock of the Issuer in the open market,  Aries II used its general funds
        to purchase an aggregate of 10,382  shares of Common Stock of the Issuer
        in the open market and the Aries Fund used its general funds to purchase
        an aggregate of 246,964 shares of Common Stock of the Issuer in the open
        market.  In  addition,  on April 15, 1999,  pursuant to the  contractual
        provisions  of its  investment  in a private  placement of the Issuer on
        October 16, 1997 (the "Private  Placement"),  Aries Domestic received an
        additional  issuance  28,276 Shares of Issuer common stock and the Aries
        Fund received an  additional  issuance of 56,080 Shares of Issuer common
        Stock.

Since April 22, 1999, Aries Fund made the following open market acquisitions:

                             Date           No. of Shares      Price
                             ----           -------------      -----
                            04/22/99              850          $2.063
                            04/23/99              850          $2.000
                            04/26/99              950          $1.688
                            04/27/99              850          $1.688
                            04/28/99              850          $1.688
                            04/29/99              850          $1.688
                            04/30/99              650          $1.750
                            05/03/99              350          $1.688
                            05/04/99              700          $1.750
                            05/05/99              700          $1.625
                            05/06/99              700          $1.813
                            05/07/99            1,000          $1.938
                            05/10/99            1,120          $1.938
                            05/11/99            1,120          $1.793
                            05/12/99            1,120          $1.938
                            05/13/99            1,120          $1.938
                            05/14/99            1,120          $2.000
                            05/17/99            1,400          $1.875
                            05/18/99            1,400          $2.000
                            05/19/99            1,400          $1.906
                            05/20/99            1,400          $2.000
                            05/21/99            1,400          $1.938
                            05/24/99            1,540          $1.938
                            05/25/99            1,540          $2.000
                            05/26/99            1,540          $1.875
                            05/27/99            1,540          $1.938
                            05/28/99            1,540          $2.125
                            06/01/99            1,540          $2.000
                            06/01/99              200          $2.000
                            06/02/99            1,540          $2.000
                            06/03/99            1,540          $2.000
                            06/04/99            1,540          $2.000
                            06/07/99            1,190          $1.938
                            06/08/99            1,190          $2.000
                            06/09/99            1,190          $2.000
                            06/10/99            1,190          $2.000
                            06/11/99            1,190          $1.875
                            06/14/99            1,050          $2.000
                            06/15/99            1,050          $1.875
                            06/16/99            1,050          $1.938
                            06/17/99            1,050          $1.875
                            06/18/99            1,050          $1.875
                            06/21/99            1,260          $1.875
                            06/23/99            1,260          $1.875
                            06/24/99            1,260          $1.875
                            06/25/99            1,260          $1.813
                            06/28/99            1,700          $1.813
                            06/29/99            1,260          $1.875
                            06/30/99            1,260          $1.875


                                  Page 8 of 19
<PAGE>

                             Date           No. of Shares      Price
                             ----           -------------      -----
                            07/07/99            1,242          $2.125
                            07/08/99            1,240          $2.125
                            07/09/99            1,800          $1.975
                            07/12/99            1,794          $2.000
                            07/13/99            1,794          $1.813
                            07/14/99            1,794          $1.875
                            07/15/99            1,794          $1.745
                            07/16/99            1,794          $1.813
                            07/19/99            1,789          $1.688
                            07/20/99            1,789          $1.688
                            07/21/99            1,789          $1.625
                            07/22/99            1,789          $1.625
                            07/23/99            1,789          $1.625
                            07/26/99            2,065          $1.625
                            07/27/99            2,064          $1.625
                            07/28/99            2,065          $1.625
                            07/29/99            2,065          $1.625
                            07/30/99            2,065          $1.563
                            08/02/99            2,202          $1.563
                            08/03/99            1,102          $1.750
                            08/04/99            2,070          $1.792
                            08/05/99            2,064          $1.583
                            08/06/99            2,064          $1.708
                            08/09/99            2,133          $1.750
                            08/10/99            2,133          $1.750
                            08/11/99            2,133          $1.813
                            08/12/99            2,133          $1.813
                            08/13/99            2,133          $1.625
                            08/16/99            2,133          $1.625
                            08/17/99            1,858          $1.625
                            08/18/99            1,858          $1.625
                            08/19/99            3,440          $2.938
                            08/19/99            6,880          $2.570
                            08/19/99            3,440          $2.553
                            08/20/99            3,440          $2.563
                            08/20/99            6,880          $2.628
                            08/23/99            3,440          $2.750
                            08/23/99            3,440          $2.562
                            08/24/99            6,880          $2.415
                            08/24/99            6,880          $2.435
                            08/25/99            3,440          $2.344
                            08/26/99            6,880          $2.625
                            08/26/99            6,880          $2.663
                            08/30/99            3,440          $2.520
                            08/30/99            6,880          $2.433
                            08/31/99           13,760          $2.685
                            09/01/99            1,926          $1.830
                            09/02/99            1,926          $1.853
                            09/03/99            1,920          $1.938
                            09/07/99            1,920          $1.938
                            09/08/99            1,371          $2.000
                            09/09/99            1,372          $1.938
                            09/10/99            1,372          $2.000
                            09/13/99            1,372          $1.938
                            09/14/99            1,372          $2.250
                            09/15/99            1,372          $2.000
                            09/16/99            1,372          $2.156
                            09/17/99            1,372          $2.000
                            09/20/99            2,743          $2.250
                            09/21/99            2,743          $2.169
                            09/22/99            2,743          $2.141
                            09/23/99            2,743          $2.078
                            09/24/99            2,743          $2.094
                            09/27/99            2,743          $2.234
                            09/28/99            2,743          $2.000
                            09/29/99            2,743          $2.000
                            09/30/99            2,743          $1.875
                             10/1/99            4,468          $2.188
                             10/1/99            2,745          $2.188
                             10/4/99            3,088          $2.063
                             10/5/99            3,088          $2.125


                                  Page 9 of 19
<PAGE>

                             10/6/99            3,088          $2.000
                             10/7/99            3,088          $2.000
                             10/8/99            3,088          $2.056
                            10/11/99            3,088          $2.000
                            10/12/99            3,088          $2.125
                            10/13/99            3,088          $2.035
                            10/14/99            3,088          $1.938
                            10/15/99            3,088          $1.924
                            10/18/99            3,088          $1.938
                            10/19/99            3,088          $1.967
                            10/20/99            3,075          $1.563
                            10/21/99            3,075          $1.438
                            10/22/99            3,075          $1.500
                            10/25/99            3,827          $1.625
                            10/26/99            3,827          $1.790
                            10/27/99            3,827          $1.848
                            10/28/99            3,827          $1.563
                            10/29/99            3,827          $1.250


                                  Page 10 of 19
<PAGE>

Since  April  22,  1999,   Aries   Domestic  made  the  following   open  market
acquisitions:

                             Date           No. of Shares     Price
                             ----           -------------     -----
                            04/22/99          400            $2.063
                            04/23/99          400            $2.000
                            04/26/99          300            $1.688
                            04/27/99          400            $1.688
                            04/28/99          400            $1.688
                            04/29/99          400            $1.688
                            04/30/99          300            $1.750
                            05/03/99          150            $1.688
                            05/04/99          290            $1.750
                            05/05/99          290            $1.625
                            05/06/99          290            $1.813
                            05/10/99          470            $1.938
                            05/11/99          480            $1.793
                            05/12/99          470            $1.938
                            05/13/99          475            $1.938
                            05/17/99          590            $1.875
                            05/17/99          470            $2.000
                            05/18/99          590            $2.000
                            05/19/99          590            $1.906
                            05/20/99          594            $2.000
                            05/21/99          590            $1.938
                            05/24/99          650            $1.938
                            05/25/99          650            $2.000
                            05/26/99          650            $1.875
                            05/27/99          650            $1.938
                            05/28/99          650            $2.125
                            05/03/99          500            $1.688
                            05/04/99           10            $1.750
                            05/05/99           10            $1.625
                            05/06/99           10            $1.813
                            05/10/99           10            $1.938
                            05/12/99           10            $1.938
                            05/13/99            5            $1.938
                            05/17/99           10            $1.875
                            05/17/99           10            $2.000
                            05/18/99           10            $2.000
                            05/19/99           10            $1.906
                            05/20/99            6            $2.000
                            05/21/99           10            $1.938
                            05/24/99           10            $1.938
                            05/25/99           10            $2.000
                            05/26/99           10            $1.875
                            05/27/99           10            $1.875
                            05/28/99           10            $1.875
                            06/01/99          650            $2.000
                            06/02/99          650            $2.000
                            06/03/99          650            $2.000
                            06/04/99          650            $2.000
                            06/07/99          500            $1.938
                            06/08/99          505            $2.000
                            06/09/99          500            $2.000
                            06/10/99          500            $2.000
                            06/11/99          500            $1.875
                            06/14/99          440            $2.000
                            06/15/99          450            $1.875
                            06/16/99          440            $1.938
                            06/17/99          446            $1.875
                            06/18/99          446            $1.875
                            06/21/99          535            $1.875
                            06/22/99          540            $1.875
                            06/23/99          530            $1.875
                            06/24/99          530            $1.875
                            06/25/99          530            $1.813
                            06/29/99          530            $1.875
                            06/30/99          520            $1.875
                            07/02/99        1,800            $1.938
                            07/06/99        1,800            $1.938
                            07/07/99          540            $2.125


                                  Page 11 of 19
<PAGE>

                            07/08/99          540            $2.125
                            07/12/99          780            $2.000
                            07/13/99          780            $1.813
                            07/14/99          780            $1.875
                            07/15/99          780            $1.745
                            07/16/99          780            $1.813
                            07/19/99          776            $1.688
                            07/20/99          776            $1.688
                            07/21/99          776            $1.625
                            07/22/99          776            $1.625
                            07/23/99          776            $1.625
                            07/26/99          895            $1.625
                            07/27/99          896            $1.625
                            07/28/99          895            $1.625
                            07/29/99          895            $1.625
                            08/02/99          946            $1.563
                            08/03/99          474            $1.750
                            08/04/99          900            $1.792
                            08/05/99          888            $1.583
                            08/06/99          888            $1.708
                            08/09/99          917            $1.750
                            08/10/99          917            $1.750
                            08/11/99          917            $1.813
                            08/12/99          917            $1.813
                            08/13/99          917            $1.625
                            08/16/99          917            $1.625
                            08/17/99          799            $1.625
                            08/18/99          799            $1.625
                            08/19/99        1,480            $2.938
                            08/19/99        1,480            $2.570
                            08/19/99        2,959            $2.553
                            08/20/99        2,959            $2.563
                            08/20/99        1,480            $2.628
                            08/23/99        1,480            $2.750
                            08/23/99        1,480            $2.562
                             8/24/99        2,959            $2.415
                             8/24/99        2,959            $2.435
                             8/25/99        1,480            $2.344
                             8/26/99        2,959            $2.625
                             8/26/99        2,959            $2.663
                             8/30/99        1,480            $2.520
                             8/30/99        2,959            $2.433
                             8/31/99        5,918            $2.685
                              9/1/99          829            $1.830
                              9/2/99          835            $1.853
                              9/3/99          835            $1.938
                              9/7/99          597            $1.938
                              9/8/99          596            $2.000
                              9/9/99          596            $1.938
                             9/10/99          596            $2.000
                             9/13/99          596            $1.938
                             9/14/99          596            $2.250
                             9/15/99          596            $2.000
                             9/16/99          596            $2.156
                             9/17/99          596            $2.000
                             9/20/99        1,192            $2.250
                             9/21/99        1,192            $2.169
                             9/22/99        1,192            $2.141
                             9/23/99        1,192            $2.078
                             9/24/99        1,192            $2.094
                             9/27/99        1,192            $2.234
                             9/28/99        1,192            $2.000
                             9/29/99        1,192            $2.000
                             9/30/99        1,192            $1.875
                            10/01/99        1,173            $2.188
                            10/04/99        1,320            $2.063
                            10/05/99        1,320            $2.125
                            10/06/99        1,320            $2.000
                            10/07/99        1,320            $2.000
                            10/08/99        1,320            $2.056
                            10/11/99        1,320            $2.000
                            10/12/99        1,320            $2.125
                            10/13/99        1,320            $2.035
                            10/14/99        1,320            $1.938
                            10/15/99        1,320            $1.924


                                  Page 12 of 19
<PAGE>

                            10/18/99        1,320            $1.938
                            10/19/99        1,320            $1.967
                            10/20/99        1,327            $1.563
                            10/21/99        1,327            $1.438
                            10/22/99        1,327            $1.500
                            10/25/99        1,651            $1.625
                            10/26/99        1,651            $1.790
                            10/27/99        1,651            $1.848
                            10/28/99        1,651            $1.563


                                  Page 13 of 19
<PAGE>

Since April 22, 1999, Aries II made the following open market purchases:

                             Date           No. of Shares       Price
                             ----           -------------       -----
                            05/03/99            500           $1.688
                            05/04/99             10           $1.750
                            05/05/99             10           $1.625
                            05/06/99             10           $1.813
                            05/10/99             10           $1.938
                            05/12/99             10           $1.938
                            05/13/99              5           $1.938
                            05/17/99             10           $1.875
                            05/17/99             10           $2.000
                            05/18/99             10           $2.000
                            05/19/99             10           $1.906
                            05/20/99              6           $2.000
                            05/21/99             10           $1.938
                            05/24/99             10           $1.938
                            05/25/99             10           $2.000
                            05/26/99             10           $1.875
                            05/27/99             10           $1.875
                            05/28/99             10           $1.875
                            06/01/99             10           $2.000
                            06/02/99             10           $2.000
                            06/03/99             10           $2.000
                            06/04/99             10           $2.000
                            06/07/99             10           $1.938
                            06/08/99              5           $2.000
                            06/09/99             10           $2.000
                            06/10/99             10           $2.000
                            06/11/99             10           $1.875
                            06/14/99             10           $2.000
                            06/16/99             10           $1.938
                            06/17/99              4           $1.875
                            06/18/99              4           $1.875
                            06/21/99              5           $1.875
                            06/23/99             10           $1.875
                            06/24/99             10           $1.875
                            06/25/99             10           $1.813
                            06/29/99             10           $1.875
                            06/30/99             20           $1.875
                            07/01/99          1,800           $1.938
                            07/07/99             18           $2.125
                            07/08/99             20           $2.125
                            07/12/99             26           $2.000
                            07/13/99             26           $1.813
                            07/14/99             26           $1.875
                            07/15/99             26           $1.745
                            07/16/99             26           $1.813
                            07/16/99             35           $1.625
                            07/19/99             35           $1.688
                            07/20/99             35           $1.688
                            07/21/99             35           $1.625
                            07/22/99             35           $1.625
                            07/23/99             35           $1.625
                            07/26/99             40           $1.625
                            07/27/99             40           $1.625
                            08/19/99            161         $  2.938
                            08/19/99             80         $  2.570
                            08/19/99             80         $  2.553
                            08/20/99             80         $  2.563
                            08/20/99            161         $  2.628
                            08/23/99             80         $  2.750
                            08/23/99             80         $  2.562
                            08/24/99            161         $  2.415
                            08/24/99            161         $  2.435
                            08/25/99             80         $  2.344
                            08/26/99            161         $  2.625
                            08/26/99            161         $  2.663
                            08/30/99             80         $  2.520
                            08/30/99            161         $  2.433
                            08/31/99            322         $  2.685
                            09/01/99             45         $  1.830


                                  Page 14 of 19
<PAGE>

                            09/02/99             45         $  1.853
                            09/03/99             45         $  1.938
                            09/07/99             32         $  1.938
                            09/08/99             32         $  2.000
                            09/09/99             32         $  1.938
                            09/10/99             32         $  2.000
                            09/13/99             32         $  1.938
                            09/14/99             32         $  2.250
                            09/15/99             32         $  2.000
                            09/16/99             32         $  2.156
                            09/17/99             32         $  2.000
                            09/20/99             65         $  2.250
                            09/21/99             65         $  2.169
                            09/22/99             65         $  2.141
                            09/23/99             65         $  2.078
                            09/24/99             65         $  2.094
                            09/27/99             65         $  2.234
                            09/28/99             65         $  2.000
                            09/29/99             65         $  2.000
                            09/30/99             65         $  1.875
                             10/1/99          1,860         $  2.188
                             10/1/99             82         $  2.188
                             10/4/99             92         $  2.063
                             10/5/99             92         $  2.125
                             10/6/99             92         $  2.000
                             10/7/99             92         $  2.000
                             10/8/99             92         $  2.056
                            10/11/99             92         $  2.000
                            10/12/99             92         $  2.125
                            10/13/99             92         $  2.035
                            10/14/99             92         $  1.938
                            10/15/99             92         $  1.924
                            10/18/99             92         $  1.938
                            10/19/99             92         $  1.967
                            10/20/99             98         $  1.563
                            10/21/99             98         $  1.438
                            10/22/99             98         $  1.500
                            10/25/99            122         $  1.625
                            10/26/99            122         $  1.790
                            10/27/99            122         $  1.848
                            10/28/99            122         $  1.563


                                  Page 15 of 19
<PAGE>

Item 4. Purpose of Transaction.

        The Reporting  Parties  acquired shares of Common Stock of the Issuer as
        an investment in the Issuer.

        Although the Reporting Parties have not formulated any definitive plans,
        they may from time to time  acquire,  or dispose of, Common Stock and/or
        other securities of the Issuer if and when they deem it appropriate. The
        Reporting  Parties may  formulate  other  purposes,  plans or  proposals
        relating to any of such  securities  of the Issuer to the extent  deemed
        advisable in light of market conditions,  investment  policies and other
        factors.

        Except  as  indicated  in  this  Schedule  13D,  the  Reporting  Parties
        currently  have no plans or proposals  that relate to or would result in
        any of the matters  described in subparagraphs (a) through (j) of Item 4
        of Schedule 13D.

Item 5. Interest in Securities of the Issuer.

        (a)      As of Nov 1, 1999,  Dr.  Rosenwald,  both  personally  and
                 through  acquisition  of the shares by the Aries  Fund,  Aries
                 Domestic and Aries II, beneficially owned 4,551,538 Shares or
                 39.22%  of  the  Issuer's   securities  and  Paramount  Capital
                 beneficially  owned  3,117,585  Shares or 30.2% of the Issuer's
                 securities.  Aries  Domestic and the Aries Fund  beneficially
                 owned as fol-lows:
                                                               Amount Owned
                                                               ------------
                      Aries Domestic                          973,398 Shares
                      Aries II                                 10,504 Shares
                      Aries Fund                            2,133,638 Shares

Pursuant to Rule 13d-4 promulgated under the Securities Exchange Act of 1934, as
amended,  the  Reporting  Person's  each  disclaim  beneficial  ownership of the
securities held by each other.

         (b)     Dr. Rosenwald and Paramount  Capital share the power to vote or
                 to direct the vote, to dispose or to direct the  disposition of
                 those  shares  owned  by each of Aries  Domestic,  Aries II and
                 Aries Fund.


                                  Page 16 of 19
<PAGE>

          Other than as set forth herein the Report-ing Parties have not engaged
          in any transactions in the Common Stock of the Issu-er during the past
          60 days.

          (d) & (e)         Not applicable.

Item 6.  Contracts,  Arrangements,  Understandings or Relationships with respect
         to Securities of the Issuer

         Paramount  Capital is the Investment  Manager of the Aries Fund and the
         General  Partner  of each of Aries  Domestic  and  Aries II and in such
         capacities  has the authority to make certain  investment  decisions on
         behalf of such entities, including decisions relating to the securities
         of the Issuer.  In connection  with its investment  management  duties,
         Paramount  Capital  receives  certain  management  fees and performance
         allocations from the Aries Fund, Aries Domestic and Aries II.

         Dr.  Rosenwald  is the  Chairman  and  sole  stockholder  of  Paramount
         Capital.  Mr. Steve Kanzer,  formerly a Senior Managing Director of the
         Placement  Agent (as defined  below),  joined the Board of Directors of
         the Issuer in connection with the initial  investment by Aries Domestic
         and the  predecessor  in interest to the Aries Fund, the Aries Trust, a
         Cayman  Island  trust in June 1996 and receives  compensation  for such
         services.

         Pursuant  to Article 6 of the  Subscription  Agreement  executed by the
         Issuer and each investor in the Private  Placement,  the Aries Fund and
         Aries Domestic are entitled to the contractual  rights (the "Article VI
         Rights") attached to the shares of Common Stock acquired in the Private
         Placement as set forth in Exhibit A to Amendment No. 4.

         Paramount Capital,  Inc., (the "Placement Agent") an NASD member broker
         dealer and an affiliate of Aries  Domestic and the Aries Fund has acted
         as  Placement  Agent for the Issuer and has  received  certain fees for
         such services including warrants (the "Placement Warrants") to purchase
         864,865 shares of Common Stock with attached  contractual  rights at an
         exercise  price equal to $2.54375.  On October 16, 1997, the Issuer and
         the Placement Agent


                                  Page 17 of 19
<PAGE>

         entered into a twenty-four (24) month engagement agreement, pursuant to
         which the Placement Agent received a cash retainer and standard success
         fees.  In addition the Placement  Agent and/or its  designees  received
         warrants  (the  "Advisory  Warrants") to purchase  1,297,297  shares of
         Common  Stock with  attached  contractual  rights at an exercise  price
         equal to $2.54375.  The  engagement  agreement  expired by its terms on
         October  16,  1999.   The  Placement  and  Advisory   Warrants   became
         exercisable on April 16, 1998.

         Except as  indicated  in this 13D and  exhibits,  there is no contract,
         arrangement,   understanding  or  relationship  between  the  Reporting
         Parties and any other  person,  with respect to any  securities  of the
         Issuer.

Item 7.  Material to be Filed as Exhibits:

Exhibit A -  Copy of an  Agreement  between Dr.  Rosenwald,  Paramount  Capital,
             Aries  Domestic  Aries II and Aries Fund to file this  Statement on
             Schedule 13D on behalf of each of them.

Exhibit B -  List of executive  officers and directors of Paramount  Capital and
             information  called for by Items 2-6 of this statement  relating to
             said officers and directors.

Exhibit C -  List of  executive  officers and  directors  of Aries  Domestic and
             Aries II and information  called for by Items 2-6 of this statement
             relating to said officers and directors.

Exhibit D -  List  of  executive  officers  and  directors  of  Aries  Fund  and
             information  called for by Items 2-6 of this statement  relating to
             said officers and directors.


                                  Page 18 of 19
<PAGE>

                                   SIGNATURES


               After  reasonable  inquiry  and to the best of my  knowledge  and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


                    PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.


Dated:         November 5, 1999
               New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                           ------------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            Chairman


                                         ARIES DOMESTIC FUND, L.P.
                                         By: Paramount Capital Asset Management,
                                             Inc.
                                             General Partner

Dated:         November 5, 1999
               New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                           ------------------------------------
                                           Lindsay A. Rosenwald, M.D.
                                           Chairman


                                         ARIES DOMESTIC FUND II, L.P.
                                         By: Paramount Capital Asset Management,
                                             Inc.
                                             General Partner

Dated:         November 5, 1999
               New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                           ------------------------------------
                                           Lindsay A. Rosenwald, M.D.
                                           Chairman


                                         THE ARIES FUND
                                         By: Paramount Capital Asset Management,
                                             Inc.
                                             Investment Manager


Dated:         November 5, 1999
               New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                           ------------------------------------
                                           Lindsay A. Rosenwald, M.D.
                                           Chairman


Dated:         November 5, 1999
               New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                           ------------------------------------
                                           Lindsay A. Rosenwald, M.D.


                                 Page 19 of 19
<PAGE>

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D

               The  undersigned  hereby agrees to jointly  prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each of the  undersigned's  ownership of securities of Endorex Corp.,
and hereby affirm that such Schedule 13D is being filed on behalf of each of the
undersigned.


                                        PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:         November 1, 1999
               New York, NY             By /s/ Lindsay A. Rosenwald. M.D.
                                          ------------------------------------
                                               Lindsay A. Rosenwald, M.D.
                                               Chairman


                                        ARIES DOMESTIC FUND, L.P.
                                        By: Paramount Capital Asset Management,
                                            Inc.
                                            General Partner

Dated:         November 1, 1999
               New York, NY             By /s/ Lindsay A. Rosenwald. M.D.
                                          -------------------------------------
                                               Lindsay A. Rosenwald, M.D.
                                               Chairman


                                        ARIES DOMESTIC FUND II, L.P.
                                        By: Paramount Capital Asset Management,
                                            Inc.
                                            General Partner

Dated:         November 1, 1999
               New York, NY             By /s/ Lindsay A. Rosenwald. M.D.
                                          -------------------------------------
                                               Lindsay A. Rosenwald, M.D.
                                               Chairman

                                        THE ARIES FUND
                                        By: Paramount Capital Asset Management,
                                            Inc.
                                            Investment Manager

Dated:         November 1, 1999
               New York, NY             By /s/ Lindsay A. Rosenwald. M.D.
                                          -------------------------------------
                                               Lindsay A. Rosenwald, M.D.
                                               Chairman


Dated:         November 1, 1999
               New York, NY             By /s/ Lindsay A. Rosenwald. M.D.
                                          -------------------------------------
                                               Lindsay A. Rosenwald, M.D.

<PAGE>

                                    EXHIBIT B

        The name and principal occupation or employment,  which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                           PRINCIPAL OCCUPATION
        NAME                                  OR EMPLOYMENT
        ----                                  -------------

Lindsay A. Rosenwald, M.D.         Chairman  of the Board of  Paramount  Capital
                                   Asset  Management,  Inc.,  Paramount  Capital
                                   Investments, LLC and Paramount Capital, Inc.

Mark C. Rogers, M.D.               President   of   Paramount    Capital   Asset
                                   Management,     Inc.,    Paramount    Capital
                                   Investments, LLC and Paramount Capital, Inc.

Peter Morgan Kash                  Director   of   Paramount    Capital    Asset
                                   Management,  Inc., Senior Managing  Director,
                                   Paramount Capital, Inc.

Dr. Yuichi Iwaki                   Director   of   Paramount    Capital    Asset
                                   Management,  Inc., Professor,  Uni versity of
                                   Southern California School of Medicine


Item 2.

        During  the  five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.

<PAGE>

                                    EXHIBIT C

        The name and principal occupation or employment, which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic and Aries II is as follows:

                                                   PRINCIPAL OCCUPATION
        NAME                                          OR EMPLOYMENT
        ----                                          -------------

Paramount Capital Asset Management, Inc.     General Partner; Investment Manager

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five years prior to the date hereof, the above person (to the
best of  Aries  Domestic's  knowledge)  has not  been  convicted  in a  criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.

<PAGE>

                                    EXHIBIT D

        The name and principal occupation or employment,  which in each instance
is with The Aries Master Fund ("Aries Fund") located at c/o MeesPierson (Cayman)
Limited,  P.O.  Box 2003,  British  American  Centre,  Phase 3, Dr. Roy's Drive,
George Town, Grand Cayman, of each executive officer and director of Aries Trust
is as follows:

                                                       PRINCIPAL OCCUPATION
        NAME                                              OR EMPLOYMENT
        ----                                              -------------

Paramount Capital Asset Management, Inc.               Investment Manager

MeesPierson (Cayman) Management Limited                Administrator

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five  years  prior to the date  hereof,  neither of the above
persons  (to the  best of Aries  Fund's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.




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