ENDOREX CORP
SC 13D/A, 2000-02-14
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 Schedule 13D/A
                                (Amendment No. 7

                    Under the Securities Exchange Act of 1934

              Endorex Corporation (f/k/a ImmunoTherapeutics, Inc.)
           ----------------------------------------------------------
                                (Name of Issuer)

                     Common Stock, par value $.001 per share
                     ---------------------------------------
                         (Title of Class of Securities)

                                   452916 40 6
                              ---------------------
                                 (CUSIP Number)

                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                             ----------------------

       (Name, Address and Telephone Number of Person Authorized to Receive
                          Notices and Communications)

                                December 30, 1999
                            -------------------------
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which the schedule
is filed:

                                |_| Rule 13d-1(b)
                                |x| Rule 13d-1(c)
                                |_| Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be filled for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act,
but shall be subject to all other provisions of the Act (however, see the Notes
to Schedule 13D).
<PAGE>

- -------------------                                           ------------------
CUSIP No. 452916406                   13D                     Page 2 of 10 Pages
- --------------------------------------------------------------------------------

      1       NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
      2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP           (a) |_|
                                                                         (b) |_|
- --------------------------------------------------------------------------------
      3       SEC USE ONLY

- --------------------------------------------------------------------------------
      4       SOURCE OF FUNDS*

              OO (see Item 3 below)
- --------------------------------------------------------------------------------
      5       CHECH BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                             |_|
- --------------------------------------------------------------------------------
      6       CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware
- --------------------------------------------------------------------------------

              7     SOLE VOTING POWER

  NUMBER OF         None
   SHARES     ------------------------------------------------------------------
BENEFICIALLY  8     SHARED VOTING POWER
  OWNED BY
    EACH            3,428,051
  REPORTING   ------------------------------------------------------------------
   PERSON     9     SOLE DISPOSITIVE POWER
    WITH
                    None
              ------------------------------------------------------------------
              10    SHARED DISPOSITIVE POWER

                    3,428,051
- --------------------------------------------------------------------------------
     11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              3,428,051
- --------------------------------------------------------------------------------
     12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*                                                        |_|

- --------------------------------------------------------------------------------
     13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              32.4%
- --------------------------------------------------------------------------------
     14       TYPE OF REPORTING PERSON*

              CO
- --------------------------------------------------------------------------------
<PAGE>

- -------------------                                           ------------------
CUSIP No. 452916406                   13D                     Page 3 of 10 Pages
- --------------------------------------------------------------------------------

      1       NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
      2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP           (a) |_|
                                                                         (b) |_|
- --------------------------------------------------------------------------------
      3       SEC USE ONLY

- --------------------------------------------------------------------------------
      4       SOURCE OF FUNDS*

              OO (see Item 3 below)
- --------------------------------------------------------------------------------
      5       CHECH BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                             |_|
- --------------------------------------------------------------------------------
      6       CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware
- --------------------------------------------------------------------------------

              7     SOLE VOTING POWER

  NUMBER OF         None
   SHARES     ------------------------------------------------------------------
BENEFICIALLY  8     SHARED VOTING POWER
  OWNED BY
    EACH            1,063,760
  REPORTING   ------------------------------------------------------------------
   PERSON     9     SOLE DISPOSITIVE POWER
    WITH
                    None
              ------------------------------------------------------------------
              10    SHARED DISPOSITIVE POWER

                    1,063,760
- --------------------------------------------------------------------------------
     11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              1,063,760
- --------------------------------------------------------------------------------
     12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*                                                        |_|

- --------------------------------------------------------------------------------
     13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              10.2%
- --------------------------------------------------------------------------------
     14       TYPE OF REPORTING PERSON*

              PN
- --------------------------------------------------------------------------------
<PAGE>

- -------------------                                           ------------------
CUSIP No. 452916406                   13D                     Page 4 of 10 Pages
- --------------------------------------------------------------------------------

      1       NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              The Aries Domestic Fund II, L.P.
- --------------------------------------------------------------------------------
      2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP           (a) |_|
                                                                         (b) |_|
- --------------------------------------------------------------------------------
      3       SEC USE ONLY

- --------------------------------------------------------------------------------
      4       SOURCE OF FUNDS*

              OO (see Item 3 below)
- --------------------------------------------------------------------------------
      5       CHECH BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                             |_|
- --------------------------------------------------------------------------------
      6       CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware
- --------------------------------------------------------------------------------

              7     SOLE VOTING POWER

  NUMBER OF         None
   SHARES     ------------------------------------------------------------------
BENEFICIALLY  8     SHARED VOTING POWER
  OWNED BY
    EACH            17,346
  REPORTING   ------------------------------------------------------------------
   PERSON     9     SOLE DISPOSITIVE POWER
    WITH
                    None
              ------------------------------------------------------------------
              10    SHARED DISPOSITIVE POWER

                    17,346
- --------------------------------------------------------------------------------
     11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              17,346
- --------------------------------------------------------------------------------
     12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*                                                        |_|

- --------------------------------------------------------------------------------
     13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              0.2%
- --------------------------------------------------------------------------------
     14       TYPE OF REPORTING PERSON*

              PN
- --------------------------------------------------------------------------------
<PAGE>

- -------------------                                           ------------------
CUSIP No. 452916406                   13D                     Page 5 of 10 Pages
- --------------------------------------------------------------------------------

      1       NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              The Aries Master Fund, A Cayman Island Exempted Company
- --------------------------------------------------------------------------------
      2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP           (a) |_|
                                                                         (b) |_|
- --------------------------------------------------------------------------------
      3       SEC USE ONLY

- --------------------------------------------------------------------------------
      4       SOURCE OF FUNDS*

              OO (see Item 3 below)
- --------------------------------------------------------------------------------
      5       CHECH BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                             |_|
- --------------------------------------------------------------------------------
      6       CITIZENSHIP OR PLACE OF ORGANIZATION

              Cayman Islands
- --------------------------------------------------------------------------------

              7     SOLE VOTING POWER

  NUMBER OF         None
   SHARES     ------------------------------------------------------------------
BENEFICIALLY  8     SHARED VOTING POWER
  OWNED BY
    EACH            2,346,945
  REPORTING   ------------------------------------------------------------------
   PERSON     9     SOLE DISPOSITIVE POWER
    WITH
                    None
              ------------------------------------------------------------------
              10    SHARED DISPOSITIVE POWER

                    2,346,945
- --------------------------------------------------------------------------------
     11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              2,346,945
- --------------------------------------------------------------------------------
     12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*                                                        |_|

- --------------------------------------------------------------------------------
     13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              22.3%
- --------------------------------------------------------------------------------
     14       TYPE OF REPORTING PERSON*

              OO (see Item 2)
- --------------------------------------------------------------------------------
<PAGE>

- -------------------                                           ------------------
CUSIP No. 452916406                   13D                     Page 6 of 10 Pages
- --------------------------------------------------------------------------------

      1       NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
      2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP           (a) |_|
                                                                         (b) |_|
- --------------------------------------------------------------------------------
      3       SEC USE ONLY

- --------------------------------------------------------------------------------
      4       SOURCE OF FUNDS*

              OO (see Item 3 below)
- --------------------------------------------------------------------------------
      5       CHECH BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                             |_|
- --------------------------------------------------------------------------------
      6       CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- --------------------------------------------------------------------------------

              7     SOLE VOTING POWER

  NUMBER OF         1,434,033
   SHARES     ------------------------------------------------------------------
BENEFICIALLY  8     SHARED VOTING POWER
  OWNED BY
    EACH            3,428,051
  REPORTING   ------------------------------------------------------------------
   PERSON     9     SOLE DISPOSITIVE POWER
    WITH
                    1,434,033
              ------------------------------------------------------------------
              10    SHARED DISPOSITIVE POWER

                    3,428,051
- --------------------------------------------------------------------------------
     11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              4,862,084
- --------------------------------------------------------------------------------
     12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*                                                        |_|

- --------------------------------------------------------------------------------
     13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              40.4%
- --------------------------------------------------------------------------------
     14       TYPE OF REPORTING PERSON*

              IN
- --------------------------------------------------------------------------------
<PAGE>

Item 1. Security and Issuer.

      (a)   Common Stock, $.001 par value ("Shares")

            Endorex Corporation (f/k/a ImmunoTherapeutics, Inc.) (the "Issuer")
            900 North Shore Blvd.
            Lake Bluff, IL 60044
            (847) 604-7555

Item 2. Identity and Background.

      Names of Persons Filing:

      (a)   This statement is filed on behalf of Paramount Capital Asset
            Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
            ("Aries Domestic"), Aries Domestic Fund II, L.P. ("Aries II"), Aries
            Master Fund, a Cayman Island exempted company ("Aries Fund") and
            Lindsay A. Rosenwald, M.D. ("Dr. Rosenwald" and collectively,
            "Reporting Parties"). See attached Exhibit A which is a copy of
            their agreement in writing to file this statement on behalf of each
            of them.

      (b)   Paramount Capital's, Aries Domestic's, Aries II's and Dr.
            Rosenwald's business address is 787 Seventh Avenue, 48th Floor, New
            York, New York, 10019. The business address for Aries Fund is c/o
            MeesPierson (Cayman) Limited, P.O. Box 2003, British American
            Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

      (c)   Dr. Rosenwald is an investment banker, venture capitalist, fund
            manager and sole shareholder of Paramount Capital,(1) a Subchapter S
            corporation incorporated in Delaware. Paramount Capital is the
            General Partner of Aries Domestic,(2) a limited partnership
            incorporated in Delaware. Paramount Capital is the Investment
            Manager to Aries Fund,(3) a Cayman Islands exempted company.

      (d)   Dr. Rosenwald, Paramount Capital, Aries Domestic, Aries II and Aries
            Fund and their respective officers, directors, general partners,
            investment managers, or trustees have not, during the five years
            prior to the date hereof, been convicted in a criminal proceeding
            (excluding traffic violations or similar misdemeanors).

      (e)   Dr. Rosenwald, Paramount Capital, Aries Domestic, Aries II and Aries
            Fund and their respective officers, directors, general partners,
            investment managers, or trustees have not been, during the five
            years prior to the date hereof, parties to a civil proceeding of a
            judicial or administrative body of competent jurisdiction, as a
            result of which such person was or is subject to a judgment, decree
            or final order enjoining future violations of, or prohibiting or
            mandating activities subject to, Federal or State securities laws or
            finding any violation with respect to such laws.

      (f)   Dr. Rosenwald is a citizen of the United States.

Item 3. Source and Amount of Funds or Other Consideration.

            Since the date of Amendment No. 6 to the Original Statement on
            Schedule 13-D ("Amendment No. 6"), filed on November 5, 1999, Aries
            Domestic used its general funds to purchase an aggregate of 60,682
            shares of Common Stock of the Issuer in the open market for an
            aggregate purchase price equal to $128,829.076, Aries II used its
            general funds to purchase an aggregate of 6,842 shares of Common
            Stock of the Issuer in the open market for an aggregate purchase
            price equal to $15,071.031 and the Aries Fund used its general fund
            to purchase an aggregate of 151,386 for an aggregate purchase price
            equal to $327,138.266 shares of Common Stock of the Issuer in the
            open market. In addition, on November 15, 1999,

- ----------

      (1)   Please see attached Exhibit B indicating the executive officers and
            directors of Paramount Capital and providing information called for
            by Items 2-6 of this statement as to said officers and directors.
            Exhibit B is herein incorporated by reference.

      (2)   Please see attached Exhibit C indicating the general partner of
            Aries Domestic and Aries II and the general partner's executive
            officers and directors and providing information called for by Items
            2-6 of this statement as to said general partners, officers and
            directors. Exhibit C is herein incorporated by reference.

      (3)   Please see attached Exhibit D indicating the investment manager of
            the Aries Fund and the investment manager's executive officers and
            directors and providing information called for by Items 2-6 of this
            statement as to said investment manager and officers and directors.
            Exhibit D is herein incorporated by reference.


                                       7
<PAGE>

            pursuant to the contractual provisions of its investment in a
            private placement of the Issuer on October 16, 1997 (the "Private
            Placement"), Aries Domestic was issued 29,680 Shares of the Issuer
            as a common stock dividend (the "Common Stock Dividend") and the
            Aries Fund was issued 58,884 Shares of the Issuer as a Common Stock
            Dividend.

Item 4. Purpose of Transaction.

            The Reporting Parties acquired shares of Common Stock of the Issuer
            as an investment in the Issuer.

            Although the Reporting Parties have not formulated any definitive
            plans, they may from time to time acquire, or dispose of, Common
            Stock and/or other securities of the Issuer if and when they deem it
            appropriate. The Reporting Parties may formulate other purposes,
            plans or proposals relating to any of such securities of the Issuer
            to the extent deemed advisable in light of market conditions,
            investment policies and other factors.

            Except as indicated in this Schedule 13D, the Reporting Parties
            currently have no plans or proposals that relate to or would result
            in any of the matters described in subparagraphs (a) through (j) of
            Item 4 of Schedule 13D.

Item 5. Interest in Securities of the Issuer.

            (a)   As of February 5, 2000, Dr. Rosenwald, both personally and
                  through acquisition of the shares by the Aries Fund, Aries
                  Domestic and Aries II, beneficially owned 4,862,484 Shares or
                  40.4% of the Issuer's securities and Paramount Capital
                  beneficially owned 3,428,051 Shares or 32.4% of the Issuer's
                  securities. Aries Domestic and the Aries Fund beneficially
                  owned as follows:

                                                          Amount Owned
                                                          ------------
                  Aries Domestic                        1,063,760 Shares
                  Aries II                                 17,346 Shares
                  Aries Fund                            2,346,945 Shares

            (b)   Dr. Rosenwald and Paramount Capital share the power to vote or
                  to direct the vote, to dispose or to direct the disposition of
                  those shares owned by each of Aries Domestic, Aries II and
                  Aries Fund.

            (c)   The following acquisitions of Shares of the Issuer were made
                  by Aries Domestic since the filing of Amendment No. 6:

                           ----------------------------------------------
                             Date            Shares       Per Share Price
                           ----------------------------------------------
                           11/01/99           1,750           $ 1.625
                           ----------------------------------------------
                           11/02/99           1,750           $ 1.605
                           ----------------------------------------------
                           11/03/99           1,750           $ 1.563
                           ----------------------------------------------
                           11/05/99           1,750           $ 1.375
                           ----------------------------------------------
                           11/05/99           1,750           $ 1.547
                           ----------------------------------------------
                           11/08/99           2,089           $ 1.525
                           ----------------------------------------------
                           11/09/99           2,089           $ 1.725
                           ----------------------------------------------
                           11/10/99           2,032           $ 1.793
                           ----------------------------------------------
                           11/11/99           2,032           $ 1.788
                           ----------------------------------------------
                           11/12/99           2,032           $ 1.938
                           ----------------------------------------------
                           11/15/99           1,693           $ 2.000
                           ----------------------------------------------
                           11/16/99           1,693           $ 2.049
                           ----------------------------------------------
                           11/17/99           1,693           $ 2.000
                           ----------------------------------------------
                           11/18/99           1,693           $ 1.938
                           ----------------------------------------------
                           11/19/99           1,693           $ 2.052
                           ----------------------------------------------
                           11/22/99           1,326           $ 2.125
                           ----------------------------------------------
                           11/23/99           1,326           $ 2.174
                           ----------------------------------------------
                           11/24/99           1,326           $ 2.223
                           ----------------------------------------------
                           11/26/99           1,326           $ 2.174
                           ----------------------------------------------


                                       8
<PAGE>

                           ----------------------------------------------
                             Date            Shares       Per Share Price
                           ----------------------------------------------
                           11/29/99           1,129           $ 2.047
                           ----------------------------------------------
                           11/30/99           1,129           $ 2.063
                           ----------------------------------------------
                           12/01/99           1,106           $ 2.102
                           ----------------------------------------------
                           12/02/99           1,107           $ 2.219
                           ----------------------------------------------
                           12/03/99           1,107           $ 2.375
                           ----------------------------------------------
                           12/06/99           1,052           $ 2.280
                           ----------------------------------------------
                           12/07/99           1,052           $ 2.405
                           ----------------------------------------------
                           12/08/99           1,052           $ 2.421
                           ----------------------------------------------
                           12/09/99           1,067           $ 2.250
                           ----------------------------------------------
                           12/10/99           1,067           $ 2.438
                           ----------------------------------------------
                           12/13/99           1,067           $ 2.342
                           ----------------------------------------------
                           12/14/99           1,067           $ 2.263
                           ----------------------------------------------
                           12/15/99           1,067           $ 2.375
                           ----------------------------------------------
                           12/16/99           1,403           $ 2.413
                           ----------------------------------------------
                           12/17/99           1,403           $ 2.325
                           ----------------------------------------------
                           12/20/99           1,544           $ 2.500
                           ----------------------------------------------
                           12/21/99           1,544           $ 2.477
                           ----------------------------------------------
                           12/22/99           1,544           $ 2.500
                           ----------------------------------------------
                           12/27/99           1,796           $ 2.778
                           ----------------------------------------------
                           12/28/99           1,796           $ 2.951
                           ----------------------------------------------
                           12/29/99             561           $ 3.000
                           ----------------------------------------------
                           12/30/99             561           $ 2.938
                           ----------------------------------------------
                           01/03/00             561           $ 2.938
                           ----------------------------------------------
                           01/03/00             583           $ 2.625
                           ----------------------------------------------
                           01/07/00             523           $ 3.500
                           ----------------------------------------------

The following acquisitions of Shares of the Issuer were made by Aries II since
the filing of Amendment No. 6:

                           ----------------------------------------------
                             Date            Shares          Per Share
                                                           Purchase Price
                           ----------------------------------------------
                           11/01/99             136           $ 1.625
                           ----------------------------------------------
                           11/02/99             136           $ 1.605
                           ----------------------------------------------
                           11/03/99             136           $ 1.563
                           ----------------------------------------------
                           11/05/99             136           $ 1.375
                           ----------------------------------------------
                           11/05/99             136           $ 1.547
                           ----------------------------------------------
                           11/08/99             163           $ 1.525
                           ----------------------------------------------
                           11/09/99             162           $ 1.725
                           ----------------------------------------------
                           11/10/99             159           $ 1.793
                           ----------------------------------------------
                           11/11/99             158           $ 1.788
                           ----------------------------------------------
                           11/12/99             158           $ 1.938
                           ----------------------------------------------
                           11/15/99             132           $ 2.000
                           ----------------------------------------------
                           11/16/99             132           $ 2.049
                           ----------------------------------------------
                           11/17/99             132           $ 2.000
                           ----------------------------------------------
                           11/18/99             132           $ 1.938
                           ----------------------------------------------
                           11/19/99             132           $ 2.052
                           ----------------------------------------------
                           11/01/99             136           $ 1.625
                           ----------------------------------------------
                           11/22/99             103           $ 2.125
                           ----------------------------------------------


                                       9
<PAGE>

                           ----------------------------------------------
                             Date            Shares          Per Share
                                                           Purchase Price
                           ----------------------------------------------
                           11/23/99             104           $ 2.174
                           ----------------------------------------------
                           11/24/99             104           $ 2.223
                           ----------------------------------------------
                           11/26/99             103           $ 2.174
                           ----------------------------------------------
                           11/29/99              88           $ 2.047
                           ----------------------------------------------
                           11/30/99              88           $ 2.063
                           ----------------------------------------------
                           12/01/99              87           $ 2.102
                           ----------------------------------------------
                           12/02/99              87           $ 2.219
                           ----------------------------------------------
                           12/03/99              87           $ 2.375
                           ----------------------------------------------
                           12/06/99              83           $ 2.280
                           ----------------------------------------------
                           12/07/99              83           $ 2.405
                           ----------------------------------------------
                           12/08/99              83           $ 2.421
                           ----------------------------------------------
                           12/09/99              83           $ 2.250
                           ----------------------------------------------
                           12/10/99              83           $ 2.438
                           ----------------------------------------------
                           12/13/99              83           $ 2.342
                           ----------------------------------------------
                           12/14/99              83           $ 2.263
                           ----------------------------------------------
                           12/15/99              83           $ 2.375
                           ----------------------------------------------
                           12/16/99             109           $ 2.413
                           ----------------------------------------------
                           12/17/99             109           $ 2.325
                           ----------------------------------------------
                           12/20/99             120           $ 2.500
                           ----------------------------------------------
                           12/21/99             120           $ 2.477
                           ----------------------------------------------
                           12/22/99             120           $ 2.500
                           ----------------------------------------------
                           12/27/99             140           $ 2.778
                           ----------------------------------------------
                           12/28/99             140           $ 2.951
                           ----------------------------------------------
                           12/29/99              44           $ 3.000
                           ----------------------------------------------
                           12/30/99              44           $ 3.000
                           ----------------------------------------------
                           01/03/00              94           $ 2.625
                           ----------------------------------------------
                           01/03/00              44           $ 2.938
                           ----------------------------------------------
                           01/04/00           2,000           $ 2.688
                           ----------------------------------------------
                           01/07/00             103           $ 3.500
                           ----------------------------------------------

The following a cquisitions of Shares of the Issuer were made by Aries Fund
since the filing of Amendment No. 6:

                           ----------------------------------------------
                             Date            Shares          Per Share
                                                           Purchase Price
                           ----------------------------------------------
                           11/01/99           4,314           $ 1.61
                           ----------------------------------------------
                           11/02/99           4,314           $ 1.56
                           ----------------------------------------------
                           11/03/99           4,314           $ 1.38
                           ----------------------------------------------
                           11/05/99           4,314           $ 1.55
                           ----------------------------------------------
                           11/05/99           5,148           $ 1.53
                           ----------------------------------------------
                           11/08/99           5,149           $ 1.73
                           ----------------------------------------------
                           11/09/99           5,009           $ 1.79
                           ----------------------------------------------
                           11/10/99           5,010           $ 1.79
                           ----------------------------------------------
                           11/11/99           5,010           $ 1.94
                           ----------------------------------------------
                           11/12/99           4,175           $ 2.00
                           ----------------------------------------------
                           11/15/99           4,175           $ 2.05
                           ----------------------------------------------


                                       10
<PAGE>

                           ----------------------------------------------
                             Date            Shares          Per Share
                                                           Purchase Price
                           ----------------------------------------------
                           11/16/99           4,175           $ 2.00
                           ----------------------------------------------
                           11/17/99           4,175           $ 1.94
                           ----------------------------------------------
                           11/18/99           4,175           $ 2.05
                           ----------------------------------------------
                           11/19/99           3,271           $ 2.13
                           ----------------------------------------------
                           11/22/99           3,270           $ 2.17
                           ----------------------------------------------
                           11/23/99           3,270           $ 2.22
                           ----------------------------------------------
                           11/24/99           3,271           $ 2.17
                           ----------------------------------------------
                           11/26/99           2,783           $ 2.05
                           ----------------------------------------------
                           11/29/99           2,783           $ 2.06
                           ----------------------------------------------
                           11/30/99           2,807           $ 2.102
                           ----------------------------------------------
                           12/01/99           2,806           $ 2.219
                           ----------------------------------------------
                           12/02/99           2,806           $ 2.375
                           ----------------------------------------------
                           12/03/99           2,665           $ 2.280
                           ----------------------------------------------
                           12/06/99           2,665           $ 2.405
                           ----------------------------------------------
                           12/07/99           2,665           $ 2.421
                           ----------------------------------------------
                           12/08/99           2,650           $ 2.250
                           ----------------------------------------------
                           12/09/99           2,650           $ 2.438
                           ----------------------------------------------
                           12/10/99           2,650           $ 2.342
                           ----------------------------------------------
                           12/13/99           2,650           $ 2.263
                           ----------------------------------------------
                           12/14/99           2,650           $ 2.375
                           ----------------------------------------------
                           12/15/99           3,488           $ 2.413
                           ----------------------------------------------
                           12/16/99           3,488           $ 2.325
                           ----------------------------------------------
                           12/17/99           3,836           $ 2.500
                           ----------------------------------------------
                           12/20/99           3,836           $ 2.477
                           ----------------------------------------------
                           12/21/99           3,836           $ 2.500
                           ----------------------------------------------
                           12/22/99           4,464           $ 2.778
                           ----------------------------------------------
                           12/27/99           4,464           $ 2.951
                           ----------------------------------------------
                           12/28/99           1,395           $ 3.000
                           ----------------------------------------------
                           12/29/99           1,395           $ 2.938
                           ----------------------------------------------
                           12/30/99           1,323           $ 2.625
                           ----------------------------------------------
                           01/03/00           1,323           $ 2.625
                           ----------------------------------------------
                           01/03/00           1,395           $ 2.938
                           ----------------------------------------------
                           01/05/00           2,000           $ 2.688
                           ----------------------------------------------
                           01/06/00           2,000           $ 2.875
                           ----------------------------------------------
                           01/07/00           1,374           $ 3.500
                           ----------------------------------------------

                  Other than as set forth herein the Reporting Parties have not
                  engaged in any transactions in the Common Stock of the Issuer
                  during the past 60 days.

            (d) & (e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with respect to
        Securities of the Issuer:

            Paramount Capital is the Investment Manager of the Aries Fund and
            the General Partner of each of Aries Domestic and Aries II and in
            such capacities has the authority to make certain investment
            decisions on behalf of such entities, including


                                       11
<PAGE>

            decisions relating to the securities of the Issuer. In connection
            with its investment management duties, Paramount Capital receives
            certain management fees and performance allocations from the Aries
            Fund, Aries Domestic and Aries II.

            Dr. Rosenwald is the Chairman and sole stockholder of Paramount
            Capital. Mr. Steve Kanzer, formerly a Senior Managing Director of
            the Placement Agent (as defined below), joined the Board of
            Directors of the Issuer in connection with the initial investment by
            Aries Domestic and the predecessor in interest to the Aries Fund,
            the Aries Trust, a Cayman Island trust in June 1996 and receives
            compensation for such services.

            Pursuant to Article 6 of the Subscription Agreement executed by the
            Issuer and each investor in the Private Placement, the Reporting
            Parties are entitled to the contractual rights (the "Article VI
            Rights") attached to the shares of Common Stock acquired in the
            Private Placement as set forth in Exhibit A to Amendment No. 4.

            Paramount Capital, Inc., (the "Placement Agent") an NASD member
            broker dealer and an affiliate of Aries Domestic and the Aries Fund
            has acted as Placement Agent for the Issuer and has received certain
            fees for such services including warrants (the "Placement Warrants")
            to purchase 864,865 shares of Common Stock with attached contractual
            rights at an exercise price equal to $2.54375. On October 16, 1997,
            the Issuer and the Placement Agent entered into a twenty-four (24)
            month engagement agreement, pursuant to which the Placement Agent
            received a cash retainer and standard success fees. In addition the
            Placement Agent and/or its designees received warrants (the
            "Advisory Warrants") to purchase 1,297,297 shares of Common Stock
            with attached contractual rights at an exercise price equal to
            $2.54375. The engagement agreement expired by its terms on October
            16, 1999. The Placement and Advisory Warrants became exercisable on
            April 16, 1998.

            Except as indicated in this 13D and exhibits, there is no contract,
            arrangement, understanding or relationship between the Reporting
            Parties and any other person, with respect to any securities of the
            Issuer.

Item 7.  Material to be Filed as Exhibits:

Exhibit A - Copy of an Agreement between Dr. Rosenwald, Paramount Capital, Aries
            Domestic and Aries Fund to file this Statement on Schedule 13D on
            behalf of each of them.

Exhibit B - List of executive officers and directors of Paramount Capital and
            information called for by Items 2-6 of this statement relating to
            said officers and directors.

Exhibit C - List of executive officers and directors of Aries Domestic and Aries
            II and information called for by Items 2-6 of this statement
            relating to said officers and directors.

Exhibit D - List of executive officers and directors of Aries Fund and
            information called for by Items 2-6 of this statement relating to
            said officers and directors.


                                       12
<PAGE>

                                   SIGNATURES

            After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.

                                   SIGNATURES

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

                                   PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                   ARIES DOMESTIC FUND, L.P.
                                   By: Paramount Capital Asset Management, Inc.,
                                       General Partner


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                   ARIES DOMESTIC FUND, II L.P.
                                   By: Paramount Capital Asset Management, Inc.,
                                       General Partner


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                   THE ARIES MASTER FUND
                                   By: Paramount Capital Asset Management, Inc.
                                       Investment Manager


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                       13
<PAGE>

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D

The undersigned hereby agrees to jointly prepare and file with regulatory
authorities a Schedule 13D and any future amendments thereto reporting each of
the undersigned's ownership of securities of Nexmed, Inc. and hereby affirm that
such Schedule 13G is being filed on behalf of each of the undersigned.

                                   PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                   ARIES DOMESTIC FUND, L.P.
                                   By: Paramount Capital Asset Management, Inc.,
                                       General Partner


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                   ARIES DOMESTIC FUND, II L.P.
                                   By: Paramount Capital Asset Management, Inc.,
                                       General Partner


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                   THE ARIES FUND
                                   By: Paramount Capital Asset Management, Inc.
                                       Investment Manager


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


Dated: February 5, 2000
       New York, NY                By /s/ Lindsay A. Rosenwald
                                      ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                       14
<PAGE>

                                    EXHIBIT B

      The name and principal occupation or employment, which in each instance is
with Paramount Capital Asset Management, Inc. ("Paramount Capital") located at
787 Seventh Avenue, 48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                            PRINCIPAL OCCUPATION
         NAME                                   OR EMPLOYMENT
         ----                                   -------------

Lindsay A. Rosenwald, M.D.      Chairman of the Board of Paramount Capital Asset
                                Management, Inc., Paramount Capital Investments,
                                LLC and Paramount Capital, Inc.

Mark C. Rogers, M.D.            President of Paramount Capital Asset Management,
                                Inc., Paramount Capital Investments, LLC and
                                Paramount Capital, Inc.

Peter Morgan Kash               Director of Paramount Capital Asset Management,
                                Inc., Senior Managing Director, Paramount
                                Capital, Inc.

Dr. Yuichi Iwaki                Director of Paramount Capital Asset Management,
                                Inc., Professor, University of Southern
                                California School of Medicine

Item 2.

      During the five years prior to the date hereof, none of the above persons
(to the best of Paramount Capital's knowledge) was convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a civil proceeding of a judicial or administrative body of competent
jurisdiction, as a result of which such person was or is subject to a judgment,
decree or final order enjoining future violations of, or prohibiting or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       15
<PAGE>

                                    EXHIBIT C

      The name and principal occupation or employment, which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic and Aries II is as follows:

                                                   PRINCIPAL OCCUPATION
         NAME                                          OR EMPLOYMENT
         ----                                          -------------

Paramount Capital Asset Management, Inc.    General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

      During the five years prior to the date hereof, the above person (to the
best of Aries Domestic's knowledge) has not been convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a civil proceeding of a judicial or administrative body of competent
jurisdiction, as a result of which such person was or is subject to a judgment,
decree or final order enjoining future violations of, or prohibiting or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       16
<PAGE>

                                    EXHIBIT D

      The name and principal occupation or employment, which in each instance is
with The Aries Master Fund ("Aries Fund") located at c/o MeesPierson (Cayman)
Limited, P.O. Box 2003, British American Centre, Phase 3, Dr. Roy's Drive,
George Town, Grand Cayman, of each executive officer and director of Aries Trust
is as follows:

                                                   PRINCIPAL OCCUPATION
         NAME                                          OR EMPLOYMENT
         ----                                          -------------

Paramount Capital Asset Management, Inc.       Investment Manager

MeesPierson (Cayman) Management Limited        Administrator

      Exhibit B is hereby incorporated by reference.

Item 2.

      During the five years prior to the date hereof, neither of the above
persons (to the best of Aries Fund's knowledge) have been convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors) or
was a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction, as a result of which such person was or is subject to a
judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       17



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