PAINEWEBBER R&D PARTNERS II LP
10-Q, 1995-11-13
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549




                                   FORM 10-Q


            (X) QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF
                     THE SECURITIES EXCHANGE ACT OF 1934.
               FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 1995
                                      OR
         ( ) TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE
                       SECURITIES EXCHANGE ACT OF 1934.
                FOR THE TRANSITION PERIOD FROM ______ TO ______



                        Commission File Number 33-14582
                       PAINEWEBBER R&D PARTNERS II, L.P.
        (Exact name of registrant as specified in its charter)



                  DELAWARE                     13-3437420
       (State or other jurisdiction of      (I.R.S. Employer
       incorporation or organization)      Identification No.)



1285 AVENUE OF THE AMERICAS, NEW YORK, NEW YORK   10019
  (Address of principal executive offices)     (Zip code)
  Registrant's telephone number, including area code: (212) 713-2000




   Indicate  by  check  mark  whether  the Registrant (1) has filed all reports
required to be filed by Section 13 or 15(d)  of  the Securities Exchange Act of
1934  during  the  preceding  12 months (or for such shorter  period  that  the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.  Yes   X   No



<PAGE>
                   PAINEWEBBER R&D PARTNERS II, L.P.
                   (a Delaware Limited Partnership)

                               FORM 10-Q
                          SEPTEMBER 30, 1995

                           TABLE OF CONTENTS



                                                            PAGE
PART I.      FINANCIAL INFORMATION

Item 1.      Financial Statements

             Statements of Financial Condition              2
             (unaudited) at September 30, 1995 and
             December 31, 1994

             Statements of Operations                       3
             (unaudited) for the three months
             ended September 30, 1995 and 1994

             Statements of Operations                       4
             (unaudited) for the nine months
             ended September 30, 1995 and 1994

             Statement of Changes in Partners' Capital      5
             (unaudited) for the nine months
             ended September 30, 1995

             Statements of Cash Flows                       6
             (unaudited) for the nine months
             ended September 30, 1995 and 1994

             Notes to Financial Statements                  7-13
             (unaudited)

Item 2.      Management's Discussion and Analysis of        14-15
             Financial Condition and Results of Operations

PART II.     OTHER INFORMATION

Item 1.      Legal Proceedings                              16

Item 6.      Exhibits and Reports on Form 8-K               16

             Signatures                                     17





All  schedules are omitted either  because  they  are  not  applicable  or  the
information  required  to  be  submitted  has  been  included  in the financial
statements or notes thereto.

<PAGE>
                                  Page 2   
   
Item 1. Financial Statements

PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)

Statements of Financial Condition
(unaudited)

                                                 September 30,    December 31,
                                                         1995            1994
- ------------------------------------------------------------------------------
Assets:

  Cash                                            $      5,718     $     6,703

  Marketable securities, at market value             1,438,748       2,308,631

  Investments, at market value                       2,542,500      10,327,102

  Interest receivable                                    5,594           7,673

  Investments in product development projects          178,474         183,228

  Royalty income receivable                             29,132          42,472
                                                  ------------     -----------
Total assets                                      $  4,200,166     $12,875,809
                                                  ============     ===========


Liabilities and partners' capital:
                                                              
  Accrued liabilities                             $     72,383     $   151,442

  Partners' capital                                  4,127,783      12,724,367
                                                    
                                                  ------------     -----------
Total liabilities and partners' capital           $  4,200,166     $12,875,809
                                                  ============     ===========


- ------------------------------------------------------------------------------

See notes to financial statements.


<PAGE>
                                  Page 3

PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)

Statements of Operations
(unaudited)

For the three months ended September 30,                   1995         1994
- ------------------------------------------------------------------------------
Revenues:
  Interest income                                     $   18,624    $   25,604
  Income from product development projects               111,952        51,440  
  Unrealized appreciation (depreciation) of 
    investments and marketable securities              2,651,841        (3,427)
  Realized loss on distribution of investment
   and marketable securities                                   -      (275,278)
                                                       ---------      --------
                                                       2,782,417      (201,661)
                                                       ---------      --------

Expenses:
  Expenditures under product development 
    projects                                                   -       338,598
  Management fee                                          47,953       157,613
  General and administrative costs                        70,098        55,371
                                                       ---------      --------
                                                         118,051       551,582
                                                       ---------      --------

Net income (loss)                                    $ 2,664,366    $ (753,243)
                                                     ===========    ==========

Net income (loss)  per partnership unit:
  Limited partners (based on 8,257 units)                $319.45    $   (90.31)
  General partner                                  $   26,643.66    $(7,532.43)
- ------------------------------------------------------------------------------

See notes to financial statements.

<PAGE>
                                  Page 4
   
PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)

Statements of Operations 
(unaudited)

For the nine months ended September 30,                    1995         1994
- -------------------------------------------------------------------------------
Revenues:
  Interest income                                    $    68,874    $   79,626
  Income from product development projects               328,363       144,747
  Unrealized appreciation (depreciation) of
   investments and marketable securities               2,694,573       (11,091)
  Realized gain (loss) on distribution of 
   investments                                         2,656,630      (583,917)
                                                       ---------      --------
                                                       
                                                       5,748,440      (370,635)
                                                       ---------      --------
Expenses:
  Expenditures under product development
    projects                                                   -       921,396
  Management fee                                         299,117       472,839
  General and administrative costs                       224,834       174,106
                                                       ---------      --------
                                                         523,951     1,568,341
                                                       ---------     ---------

Net income (loss) before cumulative effect of 
  change in accounting method                          5,224,489    (1,938,976)

   Cumulative effect of change in accounting 
    method                                                     -       366,334

                                                     -----------   -----------
Net income (loss)                                    $ 5,224,489   $(1,572,642)
                                                     ===========   ===========

Net income (loss) per partnership unit before 
  cumulative effect of change in accounting 
  method:
  Limited partners (based on 8,257 units)                $626.41   $   (232.48)
  General partner                                  $   52,244.89   $(19,389.76)

Cumulative effect of change in accounting 
  method per partnership unit:
  Limited partners (based on 8,257 units)          $           -   $     43.92
  General partner                                  $           -   $  3,663.34

Net income (loss) per partnership unit:
  Limited partners (based on 8,257 units)          $      626.41   $   (188.56)
  General partner                                  $   52,244.89   $(15,726.42)

- ------------------------------------------------------------------------------

See notes to financial statements.


<PAGE>
                                  Page 5

PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)

Statement of Changes in Partners' Capital
(unaudited)
                                              Limited      General
For the nine months ended September 30, 1995  Partners     Partner     Total
- -------------------------------------------------------------------------------

Balance at December 31, 1994             $ 12,594,066  $   130,301  $12,724,367

Net income                                  5,172,244       52,245    5,224,489
Distributions to partners:
  Cash                                       (908,270)      (9,174)    (917,444)
  Cygnus Therapeutic Systems common stock (12,773,579)    (130,050) (12,903,629)

                                          -----------  -----------  -----------
Balance at September 30, 1995             $ 4,084,461     $ 43,322  $ 4,127,783
                                          ===========  ===========  ===========

- -------------------------------------------------------------------------------

See notes to financial statements.

<PAGE>
                                  Page 6

PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)

Statements of Cash Flows
(unaudited)

For the nine months ended September 30,                  1995         1994
- -------------------------------------------------------------------------------

Cash flows from operating activities:
Net income  (loss)                                  $  5,224,489   $(1,572,642)
Adjustments to reconcile net income (loss) to cash
  provided by operating activities:
Unrealized (appreciation) depreciation of 
  investments and marketable securities               (2,694,573)       11,091
Realized (gain) loss on distribution of investments   (2,656,630)      583,917
Income from product development projects                (247,855)            -
Cumulative effect of change in accounting method           -          (366,334)
                                                                           
Decrease (increase) in operating assets:
  Marketable securities                                 1,010,090    2,054,896 
  Investments                                              91,970       (4,963)
  Investments in product development projects             252,608      244,298
  Interest receivable                                       2,079        6,544 
  Royalty income receivable                                13,340       48,971
                                                                                
Decrease in operating liabilities:                                              
  Accrued liabilities                                     (79,059)     (13,778)
  Liabilities under product development projects                -     (576,018)
                                                         --------     --------
Cash provided by operating activities                     916,459      415,982
                                                         --------     --------
                                                                                
Cash flows from financing activities:                                           
  Distribution to partners                               (917,444)    (417,020)
                                                         --------     --------
Cash used for financing activities                       (917,444)    (417,020)
                                                         --------     --------

Decrease in cash                                             (985)      (1,038)

Cash at beginning of period                                 6,703        6,369
                                                         --------     --------

Cash at end of period                                $      5,718  $     5,331
                                                         ========     ========

- -------------------------------------------------------------------------------
Supplemental disclosure of cash flow information:
The Partnership paid no cash for interest during the nine months ended 
September 30, 1995 and 1994.


Supplemental schedule of non-cash activities:

- -------------------------------------------------------------------------------
For the nine months ended September 30,                1995            1994
- -------------------------------------------------------------------------------

Distribution of investments to partners:
  Alkermes, Inc. common stock                       $        -   $   1,985,385
  Cygnus Therapeutic Systems common stock           $12,903,629  $          -
- -------------------------------------------------------------------------------

See notes to financial statements.





<PAGE>
                                  Page 7

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (a Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                                (UNAUDITED)



1.  ORGANIZATION AND BUSINESS

   The financial information as of and for the periods ended September 30, 1995
and  1994  is unaudited.  However, in the opinion of management of  PaineWebber
R&D Partners  II,  L.P.  (the  "Partnership"),  such  information  includes all
adjustments, consisting only of normal recurring accruals, necessary for a fair
presentation.  The results of operations reported for the interim periods ended
September  30,  1995, are not necessarily indicative of results to be  expected
for the year ended  December  31,  1995.   These financial statements should be
read in conjunction with the most recent annual  report  of  the Partnership on
Form  10-K  for  the  year  ended December 31, 1994, and the previously  issued
quarterly reports for the quarters ended June 30 and March 31, 1995.

   The Partnership is a Delaware  limited partnership that commenced operations
on September 30, 1987 with a total  of  $72.0 million available for investment.
PWDC  Holding Company (the "Manager") is the  general  partner  of  PaineWebber
Technologies  II, L.P. (the "General Partner"), which is the general partner of
the Partnership.   PWDC  Holding  Company  is  a  wholly  owned  subsidiary  of
PaineWebber   Development  Corporation  ("PWDC"),  an  indirect,  wholly  owned
subsidiary of Paine  Webber  Group  Inc.   The  Partnership  will  terminate on
December  31,  2012,  unless  its  term  is  extended or reduced by the General
Partner.

   The principal objective of the Partnership  is  to provide long-term capital
appreciation   to   investors   through   investing  in  the  development   and
commercialization   of  new  products  with  technology   companies   ("Sponsor
Companies"), which are  expected  to  address significant market opportunities.
Once the product development phase is completed, the Sponsor Companies have the
option to license and commercialize the  products  resulting  from  the product
development  project,  and  the  Partnership  has the right to receive payments
based upon the sale of such products.  In connection  with  product development
projects  (the  "Projects"),  the  Partnership  sought  to  obtain warrants  to
purchase the common stock of Sponsor Companies.  These warrants  will  have the
potential  to provide additional capital appreciation to the Partnership  which
is not directly  dependent  upon  the outcome of the Projects (see Note 5).  In
addition, the Partnership invests as  a  limited partner in product development
limited partnerships.  Such partnerships were  formed  to develop specific, new
products  through  contracts  with  Sponsor Companies.  The  Sponsor  Companies
conduct the Projects and affiliates of  the  Sponsor Companies serve as general
partners  of  the  partnerships.   As a result of  restructuring  some  of  the
original Projects, the Partnership also  obtained  restricted  common  stock in
some  of  the  Sponsor  Companies  (see  Note  3).  As such, the Partnership is
engaged  in  diverse  Projects  through  contracts,  participation   in   other
partnerships and investments in securities of the Sponsor Companies.

   All  distributions  to the limited partners of the Partnership (the "Limited
Partners") and the General  Partner  (collectively,  the  "Partners")  from the
Partnership will initially be made pro rata in accordance with their respective
net  capital  contributions.  The following table sets forth the proportion  of
each distribution  to  be  received  by  the  Limited  Partners and the General
Partner, respectively:

<PAGE>
                                  Page 8

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (a Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                               (UNAUDITED)

(NOTE 1 CONTINUED)

                                                   Limited    General
                                                  Partners    Partner
                                                  --------    -------
   I.   Until the value of the aggregate
        distributions for each limited
        partnership unit ("Unit") equals 
        $10,000 plus simple interest
        on such amount accrued at 7% per 
        annum for each Unit sold
        at the Initial Closing (6% per 
        annum for each subsequent Unit
        sold up to the 5,000th Unit and 
        5% per annum for each Unit
        sold thereafter) ("Contribution 
        Payout")                                     99%        1%

  II.   After Contribution Payout and 
        until the value of the
        aggregate distributions for 
        each Unit equals $50,000
        ("Final Payout")                             80%       20%

 III.   After Final Payout                           75%       25%


   At  September  30,  1995,  the  Partnership  has  made cash  and securities
distributions since inception of $1,565 and $7,297 per Unit, respectively.

2.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

   The Partnership adopted the provisions of Statement  of Financial Accounting
Standards  No.  115,  "Accounting for Certain Investments in  Debt  and  Equity
Securities" ("Statement No. 115"), for investments held as of or acquired after
January 1, 1994.  In accordance  with Statement No. 115, prior period financial
statements have not been restated  to  reflect the change in accounting method.
The cumulative effect of adopting Statement  No. 115 as of January 1, 1994, was
to  increase  net  income  for the nine months ended  September  30,  1994,  by
$366,334 or $43.92 per Unit.   Prior  to the adoption of Statement No. 115, the
Partnership  accounted  for  its  investments   in   restricted   common  stock
(regardless of the restriction period) at the lower of cost or fair value.

   Marketable securities consist of a money market fund and common  stock which
are  recorded  at market value.  Marketable securities are not considered  cash
equivalents for the Statements of Cash Flows.

   Realized and  unrealized  gains  or  losses  are  determined  on  a specific
identification method and are reflected in the Statements of Operations  during
the period in which the change in value occurs.

   The  Partnership  invested in Projects, further described in Note 5, through
one of the following two vehicles:

<PAGE>
                                  Page 9

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (a Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                                (UNAUDITED)

(NOTE 2 CONTINUED)


       - Product Development Contracts
         The Partnership  paid  amounts  to  Sponsor  Companies  under  product
         development  contracts.  Such amounts were expensed by the Partnership
         when incurred by the Sponsor Companies.

       - Product Development Limited Partnerships
         The  Partnership   participates   as  a  limited  partner  in  product
         development limited partnerships formed  to develop specific products.
         Such participations are accounted for using  the  equity method.  Such
         partnerships expensed product development costs when incurred.

   The Partnership carries warrants at a zero value in cases  where the Sponsor
Company's  stock  is  not publicly traded or the exercise period has  not  been
attained.   To  the  extent  that  the  Partnership's  warrants  are  currently
exercisable and the Sponsor  Company's  stock  is publicly traded, the warrants
are carried at intrinsic value (the excess of market  price  per share over the
exercise price per share), which approximates fair value.

3. MARKETABLE SECURITIES AND INVESTMENTS

   MARKETABLE SECURITIES:

    The money market fund consists of obligations with maturities  of  one year
or less that are subject to fluctuations in value.

   At  September  30,  1995,  the  Partnership  held  the  following marketable
securities:

                                                        Market         Cost
                                                        ------         ----  
     Money market fund                                $1,199,715   $1,199,715
     Alkermes, Inc. common stock (3,227 shares)           20,975       22,589
     Cygnus, Inc. common
       stock (11,867 shares)                             218,058       69,719
                                                      ----------   ----------
                                                      $1,438,748   $1,292,023
                                                      ==========   ==========


   At  December  31,  1994,  the  Partnership  held  the  following  marketable
securities:

                                                        Market         Cost
                                                        ------         ----
     Money market fund                                $2,301,774   $2,301,774
     Alkermes, Inc. common stock (3,227 shares)            6,857       22,589
                                                      ----------   ----------
                                                      $2,308,631   $2,324,363
                                                      ==========   ==========



<PAGE>
                                  Page 10

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (a Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                              (UNAUDITED)


(NOTE 3 CONTINUED)

     Alkermes, Inc. ("Alkermes") common stock had a market  value  of $6.50 and
$2.125  per share as of September 30, 1995 and December 31, 1994, respectively.
Cygnus, Inc. (formerly, Cygnus Therapeutic Systems) ("Cygnus") common stock had
a market  value  at  September  30,  1995,  of  $18.375.  (See section entitled
"Investments".)  In conjunction with a public offering by Cygnus  of its common
stock,  the  Partnership has agreed not to sell, contract to sell or  otherwise
dispose of its  shares  of Cygnus common stock for a period expiring on January
5, 1996.

     INVESTMENTS:

     At September 30, 1995,  the  Partnership  recorded its warrant to purchase
300,000 common shares of Cygnus as an investment with a carrying value equal to
its intrinsic value of $2,542,500 (which approximates fair value)-(see Note 5).
Accordingly, the Partnership recognized unrealized  appreciation of this amount
for  the  quarter  ended September 30, 1995, which has been  reflected  in  the
accompanying Statements of Operations.

     In  December  1994  the  Partnership  and  Cygnus  entered  into  the  GMS
Technology Purchase Agreement whereby Cygnus purchased from the Partnership the
rights to glucose monitoring  system ("GMS") technology developed under product
development agreements between Cygnus and the Partnership.  In exchange for its
technology rights, the Partnership  received  1,529,941 shares of Cygnus common
stock valued at $8,988,403 which was based on the  market  price  per  share of
$5.875  on  the date of receipt. At December 31, 1994, the Partnership recorded
its Cygnus common  stock  at  the  closing  market  price  of  $6.75  per share
(totaling $10,327,102). In May 1995 the Partnership distributed to its Partners
1,518,074 shares of Cygnus common stock.  The market value of the Cygnus common
stock  on  the  date  of  distribution  was $12,903,629 ($8.50 per share).  The
carrying value of the shares distributed  was  $10,246,999 ($6.75 per share) as
of  December 31, 1994. Accordingly, the Partnership  recognized  realized  gain
upon  the  distribution  of  $2,656,630 for the nine months ended September 30,
1995.   The  remaining 11,867 shares  of  Cygnus  common  stock  were  held  as
marketable securities.

     In 1994,  in  accordance  with  the  adoption  of  Statement  No. 115, the
Partnership  commenced recording investments in restricted common stock  (where
the restriction  period  expires  in  one  year  or  less) at market value with
unrealized gains and losses reflected in the Statements  of  Operations  during
the period in which the change in value occurs.  Restricted common stock,  with
a restriction period greater than one year, is carried at the lower of cost  or
fair value.  The cumulative effect at January 1, 1994 of adopting Statement No.
115  was to increase the carrying value of the Alkermes restricted common stock
by $366,334.

    On  January 5 and August 8, 1994, 166,841 and 200,202 shares, respectively,
of Alkermes  restricted common stock were distributed by the Partnership to its
Partners.   The  market  value  of  the  Alkermes common stock on January 5 and
August  8,  1994, was $1,334,728 ($8.00 per  share)  and  $650,656  ($3.25  per
share), respectively,  compared  to the carrying value of $1,167,887 ($7.00 per
share) and $1,401,414 ($7.00 per share),  respectively.   An aggregate realized
loss of $583,917 was recognized with respect to the distributions.

<PAGE>
                                  Page 11

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (a Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                               (UNAUDITED)


4.  RELATED PARTY TRANSACTIONS

    The   Manager  receives  an  annual  management  fee  for  management   and
administrative  services  provided  to  the Partnership.  The management fee is
equal  to  2%  of the aggregate gross proceeds  received  by  the  Partnership,
reduced by the Partnership's  capital  commitments  in  Projects that have been
concluded, and the final proceeds of which (if any) have  been  distributed  to
the  Partners  of  the Partnership.  The management fee is payable quarterly in
advance and is adjusted  annually  on  the  first day of each fiscal year in an
amount proportionate to the increase in the prior  year  in  the Consumer Price
Index published by the United States Department of Labor.  The  management fees
paid by the Partnership to the Manager were $47,953 and $157,613  for the three
months  ended  September  30,  1995  and  1994, respectively, and $299,117  and
$472,839 for the nine months ended September  30,  1995 and 1994, respectively.
Aggregate  management  fees paid to the Manager since  January  1,  1994,  were
$917,912.

    As of July 1, 1995,  the  Manager had eliminated the management fee charged
for nine of the Partnership's ten  Projects  with  the  exception  being  FOCUS
Surgery, Inc.

    The  Partnership's portfolio of  a money market fund is managed by Mitchell
Hutchins Institutional  Investors  ("MHII"),  an  affiliate of PWDC.  PWDC pays
MHII a fee with respect to such money management services.

    PWDC and PaineWebber Incorporated, and its affiliates,  have  acted  in  an
investment banking capacity for several of the Sponsor Companies.  In addition,
PWDC  and  its affiliates have direct limited partnership interests in the same
Projects as the Partnership.

    The Partnership  is involved in certain legal actions.  The General Partner
believes these actions  will be resolved without material adverse effect on the
Partnership's financial statements, taken as a whole.

5.  COMMITMENTS UNDER PRODUCT DEVELOPMENT PROJECTS

    The Partnership entered  into  ten  Projects  (Alkermes; Cadre Technologies
Inc.;  Centocor  Partners  III, L.P.; Compression Labs,  Incorporated;  Cygnus;
FOCUS Surgery Inc. (formerly  Focal  Surgery,  Inc.  (successor  to  Diasonics,
Inc.));  Genentech  Clinical  Partners  IV, L.P.; Genzyme Development Partners,
L.P.;  Rogers  Corporation;  and  Synergen  Clinical  Partners,  L.P).   As  of
September 30, 1995, all of the Projects were fully funded.

    If  the  Projects  produce  any product for commercial  sale,  the  Sponsor
Companies have the option to enter  into  joint  ventures or royalty agreements
with  the  Partnership to manufacture and market the  products  developed.   In
addition, the  Sponsor  Companies have the option to purchase the Partnership's
interest in the technology.   In  consideration  for such purchase options, the
Partnership has received warrants to purchase shares  of  common  stock  of the
Sponsor Companies. These warrants were carried at zero value as of December 31,
1994.  At September 30, 1995, the market price per share of Cygnus common stock
exceeded  the  exercise  price  per  share of the warrant and, accordingly, the
Partnership

<PAGE>
                                  Page 12

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (a Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                               (UNAUDITED)

(NOTE 5 CONTINUED)

recorded this warrant as an investment  with  a  carrying  value  equal  to its
intrinsic  value which approximates fair value (see Note 3).  At September  30,
1995, the Partnership owned the following warrants:

                                                                      9/30/95
                     Number of Shares  Exercise Price   Exercise   Market Price
                that can be Purchased     per Share      Period      Per Share*
                ---------------------  -------------  -----------    ----------

Cadre Technologies Inc.       625,000     $ 5.00      Current to 6/97       (A)

Centocor, Inc.                  2,800     $13.33      Current to 2/96   $10.875

Cygnus, Inc. (B)              300,000     $ 9.90      Current to 9/97   $18.375

OEC Medical Systems, Inc.(C)  200,000     $12.70      Current to 8/97   $8.125


* The share  prices of these technology companies are generally highly volatile
  and the shares  are  often thinly  traded.   The  market  prices indicated as
  of September 30, 1995, may not be indicative of the ultimate  values, if any,
  that may be realized by the Partnership.

(A)At September 30, 1995, the common stock of Cadre Technologies  Inc.  was not
   publicly traded.

(B)The  carrying value of this warrant at its intrinsic value has been included
   in Investments  in  the  accompanying Statements of Financial Condition.  In
   conjunction with a public  offering  by  Cygnus  of  its  common  stock, the
   Partnership has agreed not to sell, contract to sell or otherwise dispose of
   its  warrant  to  purchase  Cygnus  common  shares for a period expiring  on
   January 5, 1996.

(C)In October 1993, Diasonics, Inc. completed a  major  corporate restructuring
   under  which  Diasonics, Inc.  was  divided  into  three  separate  publicly
   traded companies:  Diasonics UltraSound,  Inc.,  FOCUS Surgery  Inc. and OEC
   Medical Systems, Inc.  The Partnership's warrant is to purchase the stock of
   OEC Medical  Systems, Inc.  FOCUS  Surgery,  Inc.  will  continue to develop
   the product for which the Partnership has provided funding.

6.  INCOME TAXES

       The Partnership is not subject to federal,  state or local income taxes.
Accordingly, the individual Partners are required to  report their distributive
shares of realized income and loss on their individual federal and state income
tax returns.

<PAGE>
                                  Page 13

                   PAINEWEBBER R&D PARTNERS II, L.P.
                   (a Delaware Limited Partnership)

                     NOTES TO FINANCIAL STATEMENTS
                             (UNAUDITED)


7. LEGAL PROCEEDINGS

       On July 12, 1995, the Partnership commenced an action  against Centocor,
Inc.  ("Centocor")  and  Centocor Partners III, L.P. in the Chancery  Court  of
Delaware arising from certain agreements entered into by Centocor and Eli Lilly
& Company in July 1992.  The  Partnership's  complaint  seeks damages, interest
and expenses.  There can be no assurance that the Partnership's  claim  will be
successful.

<PAGE>
                                  Page 14



ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS

LIQUIDITY AND CAPITAL RESOURCES

  Partners'  capital  at  September 30, 1995 was $4.1 million compared to $12.7
million at December 31, 1994,  a  decrease  of $8.6 million resulting from cash
and  security distributions to the Partners of  $13.8  million  offset  by  net
income  from  operations of $5.2 million (as discussed in Results of Operations
below).

  The Partnership's  working capital is invested in marketable securities and a
money market fund.  Liquid  assets  at  September  30,  1995, were $1.4 million
compared  to  $2.3  million at December 31, 1994, a decrease  of  $0.9  million
attributable to a cash distribution to Partners of this amount.  The balance of
liquid  assets  will  be   used   for   the  payment  of  management  fees  and
administrative costs related to managing the Partnership's investments.

RESULTS OF OPERATIONS

THREE  MONTHS  ENDED SEPTEMBER 30, 1995 COMPARED  TO  THE  THREE  MONTHS  ENDED
SEPTEMBER 30, 1994:

  Net income for  the  quarter  ended  September  30,  1995,  was  $2.7 million
compared  to  a  net  loss  of  $0.7 million for the same period in 1994.   The
favorable variance of $3.4 million  was  due to an increase in revenues of $3.0
million and a decline in expenses of $0.4 million.

  Revenues for the three months ended September  30,  1995,  were  $2.8 million
compared  to  $(0.2) million for the three months ended September 30,  1994,  a
favorable variance  of  $3.0  million.   The  increase was primarily due to the
recognition of unrealized appreciation of investments and marketable securities
of  $2.6  million  during  the  quarter  ended  September  30,  1995,  and  the
recognition of unrealized loss on distribution of  investment  of  $0.3 million
during  the  quarter  ended  September  30,  1994.  At September 30, 1995,  the
Partnership  recorded  its  warrant  to  purchase  Cygnus common  stock  as  an
investment with a carrying value equal to its intrinsic  value of $2.6 million.
Accordingly, the Partnership recognized unrealized appreciation  of this amount
in  the  third  quarter  of  1995.   In August 1994 the Partnership distributed
200,202 shares of Alkermes common stock  with  a  market  value  at the date of
distribution  of  $0.6  million  compared  to a carrying value of $0.9  million
resulting in the recognition of unrealized loss of $0.3 million.

  Expenses for the three months ended September  30,  1995,  were  $0.1 million
compared  to  $0.5  million  for  the  same  period  in 1994.  The decrease  is
attributable to decreases in product development expenditures  of  $0.3 million
and  management  fees  of  $0.1  million.   During  the  third  quarter of 1994
expenditures  under product development projects was $0.3 million  attributable
to accrued payments  related  to  Cygnus.   For  the  same  period  in 1995 the
Partnership  had  no  accruals for payments to Projects.  Management fees  have
declined as a result of  the Manager's decision to eliminate the management fee
charged on certain Projects.

<PAGE>
                                  Page 15



ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS


NINE  MONTHS ENDED SEPTEMBER  30,  1995  COMPARED  TO  THE  NINE  MONTHS  ENDED
SEPTEMBER 30, 1994:

  Net income  for  the  nine  months ended September 30, 1995, was $5.2 million
compared to a net loss of $1.6  million for the same nine month period in 1994.
The favorable variance of $6.8 million  was  due  to an increase in revenues of
$6.1  million  and a decline in expenses of $1.1 million  offset  by  the  1994
cumulative effect of a change in accounting method of $0.4 million.

  The Partnership  adopted  the provisions of Statement No. 115 for investments
held  as of or acquired after  January  1,  1994.   The  cumulative  effect  of
adopting Statement No. 115 as of January 1, 1994 was to increase net income for
the nine  months ended September 30, 1994 by $0.4 million due to the difference
between the  carrying  value and market value of a restricted security position
as of December 31, 1993.   In  accordance  with Statement No. 115, prior period
financial statements have not been restated to reflect the change in accounting
method.

  Revenues for the nine months ended September  30,  1995,  were  $5.7  million
compared  to  $(0.4)  million  for the nine months ended September 30, 1994,  a
favorable variance of $6.1 million.   The  increase  was  primarily  due  to an
increase in unrealized appreciation of investments and marketable securities of
$2.7 million (see Results of Operations - Three months ended September 30, 1995
compared  to  the  three  months  ended  September 30, 1994) and an increase in
realized gain on distribution of investments  of  $3.2  million.   In  1995 the
Partnership  distributed  to  its  Partners  1,518,074  shares of Cygnus common
stock.  The market value of the Cygnus common stock at the date of distribution
was  $12.9  million  ($8.50  per share) compared to the carrying  value  as  of
December  31,  1994,  of $10.2 million  ($6.75  per  share).   The  Partnership
recognized a gain of $2.7  million  upon  distribution.   In January and August
1994  the Partnership distributed 166,841 and 200,202 shares, respectively,  of
the Alkermes  common  stock to its Partners.  The aggregate market value of the
367,043 shares of Alkermes  common  stock on the dates of distribution was $2.0
million  compared  to the carrying value  of  $2.5  million  resulting  in  the
recognition of a loss upon the distributions in the amount of $0.5 million.

  Expenses decreased  to  $0.5  million for the nine months ended September 30,
1995, compared to $1.6 million for  the  same  period  in  1994.  The favorable
variance of $1.1 million was attributable to  decreases in product  development
expenditures  of  $1.0  million  and  management  fees of $0.1 million. Product
development expenditures were $0.9 million for the  nine months ended September
30, 1994 compared to zero for the nine months ended September 30, 1995.  During
1994  the  Partnership  accrued $0.7 million for payments  due  to  Cygnus  and
expensed $0.2 million for  research  and  development  expenditures  related to
Genzyme Development Partners, L.P.  For the same period in 1995 the Partnership
had  no  accruals  for payments to Projects and accrued no accelerated research
and development expenditures  relating  to  its Projects.  Management fees have
declined as a result of the Manager's decision  to eliminate the management fee
charged on certain Projects.

<PAGE>
                                  Page 16

                         PART II.  OTHER INFORMATION

ITEM 1.LEGAL PROCEEDINGS

      ACTION AGAINST CENTOCOR, INC. AND CENTOCOR DEVELOPMENT CORPORATION III

          Information regarding this action was disclosed  on the Partnership's
      Form 10-Q for the quarter ended June 30, 1995. On or about  September 15,
      1995,  Centocor and CDC III answered the complaint, denying the  material
      allegations   thereof,  asserting  purported  affirmative  defenses,  and
      alleging a purported  cross-claim  against  CP III and a purported third-
      party  claim  against  PaineWebber Group, Inc. ("PWG"),  and  PaineWebber
      Development Corporation  ("PWDC").  Centocor and CDC III also assert that
      the Partnership cannot properly  act as a derivative plaintiff because of
      alleged conflicts of interests of PWG and PWDC.


ITEM 6.EXHIBITS AND REPORTS ON FORM 8-K

      a)  EXHIBITS:

          None

      b)  REPORTS ON FORM 8-K:

          None
<PAGE>
                                  Page 17


                              SIGNATURES


Pursuant to the requirements of Section  13 or 15(d) of the Securities Exchange
Act of 1934, the Registrant has duly caused  this  report  to  be signed on its
behalf  by  the  undersigned,  thereunto duly authorized, on this 14th  day  of
November 1995.

       PAINEWEBBER R&D PARTNERS II, L.P.

       By: PaineWebber Technologies II, L.P.
           (General Partner)

       By: PWDC Holding Company
           (General partner of the General Partner)



       By:
           -----------------------------------------
           Eugene M. Matalene, Jr.
           President and Principal Executive Officer



       By: 
           ------------------------------------------
           Pierce R. Smith
           Principal Financial and Accounting Officer




*  The capacities listed are with respect to PWDC Holding Company, the Manager,
as well as the general partner of the General Partner of the Registrant.

<PAGE>
                                  Page 17


                                 SIGNATURES

Pursuant to the requirements of  Section 13 or 15(d) of the Securities Exchange
Act of 1934, the Registrant has duly  caused  this  report  to be signed on its
behalf  by  the  undersigned, thereunto duly authorized, on this  14th  day  of
November 1995.

       PAINEWEBBER R&D PARTNERS II, L.P.

       By: PaineWebber Technologies II, L.P.
           (General Partner)

       By: PWDC Holding Company
           (General partner of the General Partner)

       By: EUGENE M. MATALENE, JR./S/
           -----------------------------------------
           Eugene M. Matalene, Jr.
           President and Principal Executive Officer

       By: PIERCE R. SMITH/S/
           ------------------------------------------
           Pierce R. Smith
           Principal Financial and Accounting Officer




*  The capacities listed are with respect to PWDC Holding Company, the Manager,
as well as the general partner of the General Partner of the Registrant.



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<NAME> PAINEWEBBER R&D PARTNERS II, L.P.
       
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<FISCAL-YEAR-END>                          DEC-31-1994
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