PAINEWEBBER R&D PARTNERS II LP
SC 13D/A, 1999-06-04
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  ------------

                                 SCHEDULE 13D/A
                                 (RULE 13D-101)

       INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13D-1(A)
                AND AMENDMENTS THERETO FILED PURSUANT TO 13D-2(A)

                              (AMENDMENT NO. 3 )(1)


                        PaineWebber R&D Partners II, L.P.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                      Units of Limited Partnership Interest
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   695922 20 3
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                 Pablo Legorreta and David Madden (800) 600-1450
             c/o Pharmaceutical Partners, L.L.C., 675 Third Avenue,
                         Suite 3000, New York, NY 10017
- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                 With Copies to:
                      F. George Davitt, Esq. (617) 248-7000
- --------------------------------------------------------------------------------
     c/o Testa, Hurwitz & Thibeault, LLP, 125 High Street, Boston, MA 02110

                                  May 24, 1999
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

     If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the
following box .

     NOTE: Schedules filed in paper format shall include a signed original and
five copies of the schedule, including all exhibits. SEE Rule 13d-7(b) for other
parties to whom copies are to be sent.




- --------
     (1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

     The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, SEE the
NOTES).

<PAGE>
                                      -2-

- --------------------------
CUSIP NO. 695922 20 3
- --------------------------

- ---------- ---------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Pharmaceutical Royalties, L.L.C.

- ---------- ---------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                         (b) / /

- ---------- ---------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------
    4      SOURCE OF FUNDS

           WC
- ---------- ---------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED         / /
           PURSUANT TO ITEMS 2(d) or 2(e)

- ---------- ---------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- ---------------------------- -------- ------------------------------------------
                                7     SOLE VOTING POWER

         NUMBER OF                    0
          SHARES             -------- ------------------------------------------
       BENEFICIALLY             8     SHARED VOTING POWER
         OWNED BY
           EACH                       452
         REPORTING           -------- ------------------------------------------
          PERSON                9     SOLE DISPOSITIVE POWER
           WITH
                                      0
                             -------- ------------------------------------------
                               10     SHARED DISPOSITIVE POWER

                                      452
- ---------- ---------------------------------------------------------------------
   11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           452
- ---------- ---------------------------------------------------------------------
   12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN    / /
           SHARES
- ---------- ---------------------------------------------------------------------
   13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           5.5%
- ---------- ---------------------------------------------------------------------
   14      TYPE OF REPORTING PERSON

           OO
- ---------- ---------------------------------------------------------------------


<PAGE>
                                      -3-

- --------------------------
CUSIP NO. 695922 20 3
- --------------------------

- ---------- ---------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Pharmaceutical Royalty Investments, Ltd.

- ---------- ---------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                         (b) / /

- ---------- ---------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------
    4      SOURCE OF FUNDS

           WC
- ---------- ---------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED         / /
           PURSUANT TO ITEMS 2(d) or 2(e)

- ---------- ---------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Bermuda
- ---------------------------- -------- ------------------------------------------
                                7     SOLE VOTING POWER

         NUMBER OF                    0
          SHARES             -------- ------------------------------------------
       BENEFICIALLY             8     SHARED VOTING POWER
         OWNED BY
           EACH                       1839
         REPORTING           -------- ------------------------------------------
          PERSON                9     SOLE DISPOSITIVE POWER
           WITH
                                      0
                             -------- ------------------------------------------
                               10     SHARED DISPOSITIVE POWER

                                      1839
- ---------- ---------------------------------------------------------------------
   11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1839
- ---------- ---------------------------------------------------------------------
   12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN    / /
           SHARES
- ---------- ---------------------------------------------------------------------
   13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           22.3%
- ---------- ---------------------------------------------------------------------
   14      TYPE OF REPORTING PERSON

           OO
- ---------- ---------------------------------------------------------------------

<PAGE>
                                      -4-

- --------------------------
CUSIP NO. 695922 20 3
- --------------------------

- ---------- ---------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Bioventure Investments, kft

- ---------- ---------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                         (b) / /

- ---------- ---------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------
    4      SOURCE OF FUNDS

           WC
- ---------- ---------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED         / /
           PURSUANT TO ITEMS 2(d) or 2(e)

- ---------- ---------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Hungary
- ---------------------------- -------- ------------------------------------------
                                7     SOLE VOTING POWER

         NUMBER OF                    0
          SHARES             -------- ------------------------------------------
       BENEFICIALLY             8     SHARED VOTING POWER
         OWNED BY
           EACH                       1839
         REPORTING           -------- ------------------------------------------
          PERSON                9     SOLE DISPOSITIVE POWER
           WITH
                                      0
                             -------- ------------------------------------------
                               10     SHARED DISPOSITIVE POWER

                                      1839
- ---------- ---------------------------------------------------------------------
   11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1839
- ---------- ---------------------------------------------------------------------
   12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN    / /
           SHARES
- ---------- ---------------------------------------------------------------------
   13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           22.3%
- ---------- ---------------------------------------------------------------------
   14      TYPE OF REPORTING PERSON

           OO
- ---------- ---------------------------------------------------------------------

<PAGE>
                                      -5-

- --------------------------
CUSIP NO. 695922 20 3
- --------------------------

- ---------- ---------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Pharmaceutical Partners, L.L.C.

- ---------- ---------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                         (b) / /

- ---------- ---------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------
    4      SOURCE OF FUNDS

           WC
- ---------- ---------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED         / /
           PURSUANT TO ITEMS 2(d) or 2(e)

- ---------- ---------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- ---------------------------- -------- ------------------------------------------
                                7     SOLE VOTING POWER

         NUMBER OF                    0
          SHARES             -------- ------------------------------------------
       BENEFICIALLY             8     SHARED VOTING POWER
         OWNED BY
           EACH                       2291
         REPORTING           -------- ------------------------------------------
          PERSON                9     SOLE DISPOSITIVE POWER
           WITH
                                      0
                             -------- ------------------------------------------
                               10     SHARED DISPOSITIVE POWER

                                      2291
- ---------- ---------------------------------------------------------------------
   11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2291
- ---------- ---------------------------------------------------------------------
   12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN    / /
           SHARES
- ---------- ---------------------------------------------------------------------
   13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           27.8%
- ---------- ---------------------------------------------------------------------
   14      TYPE OF REPORTING PERSON

           OO
- ---------- ---------------------------------------------------------------------

<PAGE>
                                      -6-

- --------------------------
CUSIP NO. 695922 20 3
- --------------------------

- ---------- ---------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Stephen Evans-Freke

- ---------- ---------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                         (b) / /

- ---------- ---------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------
    4      SOURCE OF FUNDS

           AF
- ---------- ---------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED         / /
           PURSUANT TO ITEMS 2(d) or 2(e)

- ---------- ---------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           England
- ---------------------------- -------- ------------------------------------------
                                7     SOLE VOTING POWER

         NUMBER OF                    0
          SHARES             -------- ------------------------------------------
       BENEFICIALLY             8     SHARED VOTING POWER
         OWNED BY
           EACH                       2291
         REPORTING           -------- ------------------------------------------
          PERSON                9     SOLE DISPOSITIVE POWER
           WITH
                                      0
                             -------- ------------------------------------------
                               10     SHARED DISPOSITIVE POWER

                                      2291
- ---------- ---------------------------------------------------------------------
   11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2291
- ---------- ---------------------------------------------------------------------
   12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN    / /
           SHARES
- ---------- ---------------------------------------------------------------------
   13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           27.8%
- ---------- ---------------------------------------------------------------------
   14      TYPE OF REPORTING PERSON

           IN
- ---------- ---------------------------------------------------------------------

<PAGE>
                                      -7-

- --------------------------
CUSIP NO. 695922 20 3
- --------------------------

- ---------- ---------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Pablo Legorreta

- ---------- ---------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                         (b) / /

- ---------- ---------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------
    4      SOURCE OF FUNDS

           AF
- ---------- ---------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED         / /
           PURSUANT TO ITEMS 2(d) or 2(e)

- ---------- ---------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Mexico
- ---------------------------- -------- ------------------------------------------
                                7     SOLE VOTING POWER

         NUMBER OF                    0
          SHARES             -------- ------------------------------------------
       BENEFICIALLY             8     SHARED VOTING POWER
         OWNED BY
           EACH                       2291
         REPORTING           -------- ------------------------------------------
          PERSON                9     SOLE DISPOSITIVE POWER
           WITH
                                      0
                             -------- ------------------------------------------
                               10     SHARED DISPOSITIVE POWER

                                      2291
- ---------- ---------------------------------------------------------------------
   11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2291
- ---------- ---------------------------------------------------------------------
   12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN    / /
           SHARES
- ---------- ---------------------------------------------------------------------
   13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           27.8%
- ---------- ---------------------------------------------------------------------
   14      TYPE OF REPORTING PERSON

           IN
- ---------- ---------------------------------------------------------------------

<PAGE>
                                      -8-

- --------------------------
CUSIP NO. 695922 20 3
- --------------------------

- ---------- ---------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           David Madden

- ---------- ---------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                         (b) / /

- ---------- ---------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------
    4      SOURCE OF FUNDS

           AF
- ---------- ---------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED         / /
           PURSUANT TO ITEMS 2(d) or 2(e)

- ---------- ---------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- ---------------------------- -------- ------------------------------------------
                                7     SOLE VOTING POWER

         NUMBER OF                    0
          SHARES             -------- ------------------------------------------
       BENEFICIALLY             8     SHARED VOTING POWER
         OWNED BY
           EACH                       2291
         REPORTING           -------- ------------------------------------------
          PERSON                9     SOLE DISPOSITIVE POWER
           WITH
                                      0
                             -------- ------------------------------------------
                               10     SHARED DISPOSITIVE POWER

                                      2291
- ---------- ---------------------------------------------------------------------
   11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2291
- ---------- ---------------------------------------------------------------------
   12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN    / /
           SHARES
- ---------- ---------------------------------------------------------------------
   13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           27.8%
- ---------- ---------------------------------------------------------------------
   14      TYPE OF REPORTING PERSON

           IN
- ---------- ---------------------------------------------------------------------

<PAGE>
                                      -9-

- --------------------------
CUSIP NO. 695922 20 3
- --------------------------

- ---------- ---------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Rory Riggs

- ---------- ---------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                         (b) / /

- ---------- ---------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------
    4      SOURCE OF FUNDS

           AF
- ---------- ---------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED         / /
           PURSUANT TO ITEMS 2(d) or 2(e)

- ---------- ---------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- ---------------------------- -------- ------------------------------------------
                                7     SOLE VOTING POWER

         NUMBER OF                    0
          SHARES             -------- ------------------------------------------
       BENEFICIALLY             8     SHARED VOTING POWER
         OWNED BY
           EACH                       2291
         REPORTING           -------- ------------------------------------------
          PERSON                9     SOLE DISPOSITIVE POWER
           WITH
                                      0
                             -------- ------------------------------------------
                               10     SHARED DISPOSITIVE POWER

                                      2291
- ---------- ---------------------------------------------------------------------
   11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2291
- ---------- ---------------------------------------------------------------------
   12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN    / /
           SHARES
- ---------- ---------------------------------------------------------------------
   13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           27.8%
- ---------- ---------------------------------------------------------------------
   14      TYPE OF REPORTING PERSON

           IN
- ---------- ---------------------------------------------------------------------

<PAGE>
                                      -10-


        This Amendment (the "Amendment") is Amendment No. 3 to the Schedule 13D
(the "Original Schedule 13D") as filed on November 17, 1997 with the Securities
and Exchange Commission (the "SEC"), as amended by Amendment No. 1 ("Amendment
No. 1") as filed on February 23, 1999 with the SEC and Amendment No. 2
("Amendment No. 2, the Original Schedule 13D as amended by Amendment No. 1 and
Amendment No. 2 being hereinafter referred to as the "Amended Original 13D") as
filed on March 10, 1999 with the SEC on behalf of BioRoyalties, L.L.C.
("BioRoyalties"), Pharmaceutical Royalties, L.L.C. ("PRLLC"), Pharmaceutical
Royalty Investments, Ltd. ("PRI"), Bioventure Investments, kft ("Bioventure"),
Pharmaceutical Partners, L.L.C. ("PPLLC"), Stephen Evans-Freke, Pablo Legorreta,
David Madden and Rory Riggs relating to beneficial ownership of outstanding
units of limited partnership interest (the "Units") of PaineWebber R&D Partners
II, L.P. (the "Partnership"). Amendment No. 1 constituted the final amendment to
the Original Schedule 13D filed on behalf of BioRoyalties. PRLLC, PRI,
Bioventure, PPLLC and Messrs. Evans-Freke, Legorreta, Madden and Riggs are
herein collectively referred to as the "Reporting Persons." Unless otherwise
noted, the information contained in this Amendment amends and supplements the
information previously disclosed in the Amended Original 13D.

        On March 3, 1999, PharmaInvest, L.L.C. ("PharmaInvest"), on behalf of
PRLLC and PRI, filed with the SEC a Tender Offer Statement on Schedule 14D-1
(the "1999 Offer") to acquire up to 3,000 Units of the Partnership. The 1999
Offer expired at 12:00 Midnight (Eastern Standard Time), on March 31, 1999. This
Amendment No. 3 reflects the transfer of an additional 763.5 Units of the
Partnership to the Reporting Persons pursuant to the 1999 Offer. This Amendment
No. 3 also reflects an accounting reconciliation of an additional 10.5 Units to
conform the records of the Reporting Persons to those of the Partnership.

        As used herein, the 1997 Offer shall also mean the Offer as used in the
Amended Original 13D.

ITEM 4.  PURPOSE OF THE TRANSACTION.

The information contained in this Item 4 amends and supplements the information
previously disclosed in the Amended Original 13D.

On April 5, 1999, PharmaInvest issued the Press Release attached hereto as
Exhibit 3. The information set forth in the Press Release is incorporated herein
by reference.

ITEM 5.  INTERESTS IN SECURITIES OF THE ISSUER.

The information contained in this Item 5 amends and restates, in its entirety,
the information previously disclosed in the Amended Original 13D.

(a)     PRLLC beneficially owns 452 Units (5.5%) of the outstanding Units and
        disclaims beneficial ownership of all other Units held by all other
        Reporting Persons as contemplated herein.

        Bioventure beneficially owns 1,839 Units (22.3%) of the outstanding
        Units and disclaims beneficial ownership of all other Units held by all
        other Reporting Persons as contemplated herein.

<PAGE>
                                      -11-


        PRI, as an indirect owner of Bioventure, may be deemed to beneficially
        own 1,839 Units (22.3%) of the outstanding Units and hereby disclaims
        beneficial ownership of the 1,839 Units and all other Units beneficially
        owned by all other Reporting Persons as contemplated herein.

        PPLLC is the sole manager of PRLLC and, by contract, the manager of
        Bioventure and may be deemed to own beneficially 2,291 Units (27.8%) of
        the outstanding Units. PPLLC disclaims beneficial ownership of such
        Units.

        Each of Messrs. Evans-Freke, Legorreta, Madden and Riggs are managing
        members of PPLLC and may be deemed to own beneficially 2,291 Units
        (27.8%) of the outstanding Units. Each of Messrs. Evans-Freke,
        Legorreta, Madden and Riggs disclaims beneficial ownership of such Units
        except to the extent of his indirect pecuniary interest.

(b)     Number of Units as to which each person has

        (i)     Sole power to vote or direct the vote:

                0 Units for each Reporting Person.

        (ii)    Shares power to vote or direct the vote:

                452 Units for PRLLC;

                1,839 Units for each of Bioventure and PRI; and

                2,291 Units for each of PPLLC and Messrs. Evans-Freke,
                Legorreta, Madden and Riggs.

        (iii)   Sole power to dispose or to direct the disposition:

                0 Units for each Reporting Person.

        (iv)    Shared power to dispose or to direct this disposition:

                452 Units for PRLLC;

                1,839 Units for each of Bioventure and PRI; and

                2,291 Units for each of PPLLC and Messrs. Evans-Freke,
                Legorreta, Madden and Riggs.

(c)     Pursuant to the 1997 Offer for the Units which was open from August 15,
        1997 through October 7, 1997, BioRoyalties (on behalf of PRLLC and PRI),
        PRLLC, PRI, PPLLC, and Messrs. Evans-Freke, Legorreta, Madden and Riggs
        each became the beneficial owner of 849 Units. The price per Unit in the
        1997 Offer was $3,650.

<PAGE>
                                      -12-


        From October 8, 1997 through October 1, 1998, the Reporting Persons
        entered into 26 privately negotiated transactions pursuant to which the
        Reporting Persons acquired beneficial ownership of an additional 54
        Units at prices per Unit ranging from $790 to $3,502.

        Between January 8, 1999 and March 3, 1999, the Reporting Persons were
        notified of the approval of the transfer of an additional 614 Units,
        effective January 1, 1999. The information set forth in Section 9 of the
        1999 Offer to Purchase is incorporated herein by reference.

        Pursuant to the 1999 Offer for the Units which was open from March 3,
        1999 through March 31, 1999, a total of 763.5 Units were tendered to
        PharmaInvest (on behalf of PRLLC and PRI). The price per Unit in the
        1999 Offer was $6,000. On May 6, 1999, the Reporting Persons were
        notified of the approval of the transfer of 648.0 Units to Bioventure
        and the transfer of 86.5 Units to PRLLC, and on May 24, 1999, the
        Reporting Persons were notified of the approval of the transfer of 2.5
        Units to Bioventure and the transfer of 26.5 Units to PRLLC. All
        transfers of Units pursuant to the 1999 Offer are effective
        April 1, 1999.

        Throughout the periods described in this Item 5(c), the Reporting
        Persons have made various transfers of the Units amongst their own
        affiliated entities so that ownership of the Units is as stated in Items
        5(a) and 5(b) of this Amendment.

(d)     No other person is known to have the right to receive or the power to
        direct the receipt of dividends from, or any proceeds from the sale of,
        the Units beneficially owned by any of the Reporting Persons.

(e)     As of December 31, 1997, BioRoyalties ceased to be the beneficial owner
        of more than 5% of the outstanding Units.

ITEM 7. MATERIAL TO BE FILED AS EXHIBITS.

EXHIBIT 3     Press Release dated April 5, 1999

<PAGE>
                                      -13-


                                   SIGNATURES

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


Dated:  May 31, 1999

                               PHARMACEUTICAL ROYALTIES, L.L.C.

                               By:  /s/ David Madden
                                    ----------------------------------
                               Name:      David Madden
                               Title:     Managing Member of Pharmaceutical
                                          Partners, L.L.C., the Manager


                               PHARMACEUTICAL ROYALTY INVESTMENTS LTD.

                               By:  /s/ David Madden
                                    ----------------------------------
                               Name:      David Madden
                               Title:     Managing Member of Pharmaceutical
                                          Partners, L.L.C., the Manager


                               BIOVENTURE INVESTMENTS, Kft

                               By:  /s/ David Madden
                                    ----------------------------------
                               Name:      David Madden
                               Title:     Managing Member of Pharmaceutical
                                          Partners, L.L.C., the Manager


                               PHARMACEUTICAL PARTNERS, L.L.C.

                               By:  /s/ David Madden
                                    ----------------------------------
                               Name:      David Madden
                               Title:     Managing Member


                               /s/ Stephen Evans-Freke
                               ---------------------------------------
                               Name:      Stephen Evans-Freke


                               /s/ Pablo Legorreta
                               ---------------------------------------
                               Name:      Pablo Legorreta

<PAGE>
                                      -14-


                               /s/ David Madden
                               ---------------------------------------
                               Name:      David Madden


                               /s/ Rory Riggs
                               ---------------------------------------
                               Name:      Rory Riggs





<PAGE>
                                                                       Exhibit 3



TENDER OFFER OF PHARMAINVEST, L.L.C. EXPIRES

         NEW YORK, NY (Business Wire) - Apr. 5, 1999 - The tender offer of
PharmaInvest, L.L.C. to purchase up to 3,000 of the outstanding units of limited
partnership interest (the "Units") of PaineWebber R&D Partners II, L.P. for
$6,000 per Unit expired at 12:00 Midnight, (Eastern Standard Time), on March 31,
1999. At the time of expiration, 700.5 Units had been tendered and not
withdrawn. PharmaInvest will promptly pay for all Units which were validly
tendered in the offer.

         For additional information, contact MacKenzie Partners, Inc., the
Information Agent or PharmaInvest, L.L.C., the Purchaser.

         CONTACT: MacKenzie Partners, Inc.
                  Larry Dennedy
                  Bob Marese
                  (800) 322-2885

                  PharmaInvest, L.L.C.
                  Mike Herman
                  (800) 600-1450




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