FIRST TRUST COMBINED SERIES 21
485BPOS, 1997-08-29
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                                                File No. 33-14822


               SECURITIES AND EXCHANGE COMMISSION
                   WASHINGTON, D.C. 20549-1004
                                
                         POST-EFFECTIVE
                        AMENDMENT NO. 10
                                
                               TO
                                
                            FORM S-6

For Registration Under the Securities Act of 1933 of Securities
of Unit Investment Trusts Registered on Form N-8B-2


               THE FIRST TRUST COMBINED SERIES 21
                      (Exact Name of Trust)
                                
                      NIKE SECURITIES L.P.
                    (Exact Name of Depositor)
                                
                      1001 Warrenville Road
                     Lisle, Illinois  60532
                                
  (Complete address of Depositor's principal executive offices)
                                


          NIKE SECURITIES L.P.     CHAPMAN AND CUTLER
          Attn:  James A. Bowen    Attn:  Eric F. Fess
          1001 Warrenville Road    111 West Monroe Street
          Lisle, Illinois  60532   Chicago, Illinois  60603


        (Name and complete address of agents for service)
                                
It is proposed that this filing will become effective (check
appropriate box)

:____:    immediately upon filing pursuant to paragraph (b)
:__X_:    August 29, 1997
:____:    60 days after filing pursuant to paragraph (a)
:____:    on (date) pursuant to paragraph (a) of rule (485 or
486)
     
     Pursuant to Rule 24f-2 under the Investment Company  Act  of
1940,   the  issuer  has  registered  an  indefinite  amount   of
securities.   A 24f-2 Notice for the offering was last  filed  on
June 17, 1997.
                                
                                
              CONTENTS OF POST-EFFECTIVE AMENDMENT
                    OF REGISTRATION STATEMENT
     
     This  Post-Effective  Amendment  of  Registration  Statement
comprises the following papers and documents:

                          The facing sheet

                          The purpose of the Amendment

                          The signatures

                          The Consent of Independent Auditors

                          Financial Data Schedule

                                
                                
                                
                                
                  THE PURPOSE OF THE AMENDMENT
     
     The   purpose   of  this  amendment  is  to  terminate   the
declaration  made  pursuant to Rule 24f-2 promulgated  under  the
Investment Company Act of 1940, as amended, because Units of  The
First  Trust  Combined Series 21 are no longer being offered  for
sale  in  the  secondary market.  A final Rule 24f-2 Notice  with
respect  to  such  series has been filed concurrently  with  this
filing.
                                
                           SIGNATURES
     
     Pursuant to the requirements of the Securities Act of  1933,
the  Registrant,  The First Trust Combined Series  21,  certifies
that  it meets all of the requirements for effectiveness of  this
Registration  Statement  pursuant  to  Rule  485(b)   under   the
Securities  Act  of 1933 and has duly caused this  Post-Effective
Amendment  of  its  Registration Statement to be  signed  on  its
behalf  by  the  undersigned thereunto  duly  authorized  in  the
Village of Lisle and State of Illinois on August 29, 1997.
                                    
                         THE FIRST TRUST COMBINED SERIES 21
                                                             (Registrant)
                         By      NIKE SECURITIES L.P.
                                                              (Depositor)
                         
                         
                         By      Robert M. Porcellino
                                 Vice President
                                    
     
     Pursuant to the requirements of the Securities Act of  1933,
this  Post-Effective Amendment of Registration Statement has been
signed  below by the following person in the capacity and on  the
date indicated:

Signature                  Title*                  Date

Robert D. Van Kampen  Sole Director of    )
                      Nike Securities     )
                     Corporation, the     )
                      General Partner     ) August 29, 1997
                  of Nike Securities L.P. )
                                          )
                                          )
                                          )Robert M. Porcellino
                                          )Attorney-in-Fact**


*The title of the person named herein represents his capacity  in
     and relationship to Nike Securities L.P., the Depositor.

**An executed copy of the related power of attorney was filed  wi
     th the Securities and Exchange Commission in connection with
     Amendment  No.  1  to Form S-6 of The First  Trust  Combined
     Series  258  (File  No. 33-63483) and  the  same  is  hereby
     incorporated herein by this reference.
                 CONSENT OF INDEPENDENT AUDITORS
                                
We  consent  to  the  reference to our  firm  under  the  caption
"Experts"  and to the use of our report dated July  25,  1997  in
this  Post-Effective Amendment to the Registration Statement  and
related  Prospectus  of  The First Trust  Combined  Series  dated
August 26, 1997.



                                    ERNST & YOUNG LLP




Chicago, Illinois
August 25, 1997
                                



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