APPLIED IMAGING CORP
SC 13G, 1997-02-25
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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<PAGE>

                THIS DOCUMENT IS A COPY OF THE SCHEDULE 13G 
                         FILED ON FEBRUARY 18, 1997
             PURSUANT TO A RULE 201 TEMPORARY HARDSHIP EXEMPTION

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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549

                                  SCHEDULE 13G

                   UNDER THE SECURITIES EXCHANGE ACT OF 1934
                            
                                   
                             Applied Imaging Corp.
 -------------------------------------------------------------------------------
                               (Name of Issuer)


                                 Common Stock
 -------------------------------------------------------------------------------
                        (Title of Class of Securities)


                                 141 408 10 4
 -------------------------------------------------------------------------------
                                (CUSIP Number)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                               Page 1 of 5 Pages

<PAGE>
 
- -----------------------                                  ---------------------
CUSIP NO. 141 408 10 4                   13G               PAGE 2 OF 5 PAGES
- -----------------------                                  ---------------------
 
- ------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
      
      Thompson Clive Ventures

- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]
                                                                (b) [_]
                                                 
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
 

- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4    
      Jersey, Channel Islands, United Kingdom

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5   
     NUMBER OF            359,387
 
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          0
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7    
    REPORTING             359,387
 
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          0
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9  
      703,327

- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10                  
 
 
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11    
      10.41 % undiluted; 8.07% diluted

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      OO

- ------------------------------------------------------------------------------

                     *SEE INSTRUCTION BEFORE FILLING OUT!


                               Page 2 of 5 pages

<PAGE>
 
CUSIP NO. 141 408 10 4                                        Page 3 of 5 Pages
          ------------

                                                             
ITEM 1.
        (a)  Name of Issuer    
             Applied Imaging Corp.
         
        (b)  Address of Issuer's Principal Executive Offices
             2380 Walsh Avenue 
             Bldg B 
             Santa Clara California 95051     
          
ITEM 2.
        (a)  Name of Person Filing  
             Thompson Clive Ventures
    
        (b)  Address of Principal Business Office, or if none, Residence
             28-34 Hill Street
             St. Helier, Jersey, Channel Islands JE4 8NR
          
        (c)  Citizenship  
             Jersey resident

        (d)  Title of Class of Securities
             Common Stock

        (e)  CUSIP Number
             141 408 10 4

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13(d)-2(b), 
        CHECK WHETHER PERSON IS A:

          (a)  [_]  Broker or Dealer registered under Section 15 of the Act

          (b)  [_]  Bank as defined in section 3(a)(6) of the Act

          (c)  [_]  Insurance Company as defined in section 3(a)(19) of the Act
         
          (d)  [_]  Investment Company registered under section 8 of the 
                    Investment Company Act

          (e)  [_]  Investment Adviser registered under Section 203 of the 
                    Investment Advisers Act of 1940

          (f)  [_]  Employee Benefit Plan, Pension Fund which is subject to the 
                    provisions of the Employee Retirement Income Security Act of
                    1974 or Endowment Fund, see Section 240.13d-1(b)(l)(ii)(F)

          (g)  [_]  Parent Holding Company in accordance with 
                    Section 240.13d-1(b)(1)(ii)(G) (Note: See Item 7)

          (h)  [_]  Group, in accordance with Section 240.13d-1(b)(l)(ii)(H)

The filing person acquired all of its shares prior to the registration of the 
Issuer's shares pursuant to Section 12 of the Securities Exchange Act of 1934, 
as amended; therefore, this filing is pursuant to Rule 13d-1(c)


<PAGE>
 
CUSIP NO. 141 408 10 4                                         Page 4 of 5 Pages
          ------------

ITEM 4. OWNERSHIP

        (a)  Amount Beneficially Owned:
             359,387 shares

        (b)  Percent of Class:  
             5.318%

        (c)  Number of shares as to which such person has:

             (i)   sole power to vote or to direct the vote 
                   359,387

            (ii)   shared power to vote or to direct the vote  
                   None

           (iii)   sole power to dispose or to direct the disposition of  
                   359,387

            (iv)   shared power to dispose or to direct the disposition of 
                   None 


ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

        If this statement is being filed to report the fact that as of the 
date hereof the reporting person has ceased to be the beneficial owner of more 
than five percent of the class of securities, check the following  [_]


ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.


ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
        SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.


ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP


ITEM 9. NOTICE OF DISSOLUTION OF THE GROUP


<PAGE>
 
CUSIP NO. 141 408 10 4                                         Page 5 of 5 Pages
          ------------

Item 10.

          By signing below, I certify that, to the best of my knowledge and 
belief, the securities referred to above were acquired in the ordinary course of
business and were not acquired for the purpose of and do not have the effect of
changing or influencing the control of the issuer of such securities and were
not acquired in connection with or as a participant in any transaction having
such purpose or effect.


                                   SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                                       12 February 1997
                                               ______________________________
                                                           Date


                                                    /s/ Susan A. Thompson
                                               ______________________________
                                                          Signature 
            

                                                      SUSAN A. THOMPSON
                                               ______________________________
                                                          Name/Title

                                               For and on behalf of Thompson
                                               Clive & Partners, Investment
                                               Advisor.
             
          


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