APPLIED IMAGING CORP
SC 13G/A, 1998-02-11
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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<PAGE>

                               UNITED STATES
                    SECURITIES AND EXCHANGE COMMISSION
                          WASHINGTON, D.C.  20549

                               SCHEDULE 13G

                 Under the Securities Exchange Act of 1934
                             (Amendment No. 1)

                           APPLIED IMAGING CORP.
                           ---------------------
                             (Name of Issuer)


                 Common Stock, par value, $.001 per share
           ----------------------------------------------------
                      (Title of Class of Securities)


                                 03820G106
                         ------------------------
                              (CUSIP Number)


Check the following box if a fee is being paid with this statement [ ].  (A
fee is not required only if the filing person: (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the
class of securities described in Item 1; and (2) has filed no amendment
subsequent thereto reporting beneficial ownership of five percent or less
of such class.)(See Rule 13d-7).

*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of section 18 of the Securities
Exchange Act of 1934 ("Act") or to otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of the
Act (however, see the Notes).




                         Page 1 of 7 Pages<PAGE>
<PAGE>
                         SCHEDULE 13G

- -------------------                               -----------------
CUSIP No. 03820G106                               Page 2 of 7 Pages
- -------------------                               ------------------
==========================================================================
1  NAME OF REPORTING PERSON - S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE
   PERSON
   Allen Holding Inc.                                                 
- --------------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a)  [ ]
                                                                 (b)  [x]
- --------------------------------------------------------------------------
3  SEC USE ONLY

- ---------------------------------------------------------------------------
 CITIZENSHIP OR PLACE OF ORGANIZATION
   Delaware                    
- --------------------------------------------------------------------------
     NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
- --------------------------------------------------------------------------
5  SOLE VOTING POWER
          0
- ---------------------------------------------------------------------------
6  SHARED VOTING POWER
          0        
- ---------------------------------------------------------------------------
7  SOLE DISPOSITIVE POWER
          0
- ---------------------------------------------------------------------------
8  SHARED DISPOSITIVE POWER
          0
- ---------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     528,437  (Represents shares of Common Stock beneficially owned 
               by Allen Value Partners, L.P., Allen Value Limited,
               Allen & Company Incorporated, and Allen Philton.  
               Allen Holding Inc. may be deemed to be hereinafter 
               owners of such shares.) 
- ---------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 
    CERTAIN SHARES*                                                     [x]
- ---------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         7.5%
- ---------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*
        HC
===========================================================================
                    *SEE INSTRUCTIONS BELOW BEFORE FILLING OUT!

SEC 1746 (9-88)<PAGE>
<PAGE>
                               SCHEDULE 13G

- -------------------                               --------------------
CUSIP No. 03820G106                               Page 3 of 7 Pages
- -------------------                               --------------------

===========================================================================
1  NAME OF REPORTING PERSON - S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE
   PERSON
   Allen & Company Incorporated  
- ---------------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [ ]
                                                            (b)  [x]
- --------------------------------------------------------------------------
3  SEC USE ONLY

- --------------------------------------------------------------------------
4  CITIZENSHIP OR PLACE OF ORGANIZATION
   New York
- --------------------------------------------------------------------------
     NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
- -------------------------------------------------------------------------
5  SOLE VOTING POWER
       428,968
- --------------------------------------------------------------------------
6  SHARED VOTING POWER
            0        
- --------------------------------------------------------------------------
7  SOLE DISPOSITIVE POWER
       428,968
- --------------------------------------------------------------------------
8  SHARED DISPOSITIVE POWER
            0
- ---------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       428,968
- --------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 
    CERTAIN SHARES*                                         [ ]
- --------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         6.15%
- ---------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*
        BD; CO
=========================================================================
               *SEE INSTRUCTIONS BELOW BEFORE FILLING OUT!
SEC 1746 (9-88)
<PAGE>
<PAGE>                                                 Page 4 of 7 Pages

                         SCHEDULE 13G


Item 1.

          (a)  Name of Issuer:

               Applied Imaging Corp.

          (b)  Address of Issuer's Principal Executive Office:

               2380 Walsh Avenue 
               Building B
               Santa Clara, CA 95051


Item 2.   Name of Person Filing

          (a)  Name of Person Filing:

               Allen & Company Incorporated ("ACI")
               Allen Holding Inc.("AHI")

          (b)  Address of Principal Office:

               711 Fifth Avenue
               New York, New York 10022                                     
                                                                            
                                                                            
          (c)  Citizenship/Organization:

               ACI - New York
               AHI - Delaware
          
          (d)  Title Class of Securities:

               Common Stock, par value $.001 per share

          (e)  CUSIP Number:  03820G106


Item 3.   If Statement is filed pursuant to Rules 13(d)-1(b) or 13d-2(b),
           check whether Person Filing is a 

          (a)  [X]  ACI is a Broker-Dealer registered under Section 15 of
                     the Act.
          (g)  [X]  AHI is a parent holding company in accordance with
                     Rule 13d-1(b)(ii)(G).
<PAGE>
<PAGE>                                                Page 5 of 7 Pages     
                  
Item 4.   Ownership.

          (a)  Amount Beneficially Owned: 
               528,437 shares of Common Stock(1)(2)(3)

          (b)  Percent of Class:  7.5%

          (c)  Number of Shares to Which Such Person Has:
                 (i)   Sole voting power -   528,437 shares
                                             of Common Stock(1)(2)(3)
                (ii)   Shared voting power -  0
               (iii)   Sole dispositive power -  528,437 shares
                                                 of Common Stock(1)(2)(3)
                (iv)   Shared dispositive power - 0

Item 5.   Ownership of Five Percent or Less of a Class.
          Not applicable.

Item 6.   Ownership of More Than Five Percent on Behalf of Another Person.
          Not Applicable.

Item 7.   Identification and Classification of Members of the Subsidiary
          Which Acquired the Securities Being Reported on by the Parent
          Holding Company.

          Not Applicable.

Item 8.   Identification and Classification of Members of the Group.
          Not Applicable.

Item 9.   Notice of Dissolution of Group.
          Not Applicable.

(1)  Includes 324,176 shares of Common Stock and 58,645 shares issuable
upon exercise of certain outstanding Warrants beneficially owned by Allen
Value Partners L.P. and Allen Value Ltd., which are entities which may be
deemed to be controlled by AHI. AHI disclaims beneficial ownership of the
shares beneficially owned by such entities except the extent of its
proportionate interest therein.

(2)  Includes warrants to purchase 204,261 shares of the Issuer's Common
Stock held by Allen Partners L.P., Allen Value Limited, Allen Philton and
ACI.

(3)  Excludes shares of Common Stock and shares of Common Stock issuable
upon exercise of outstanding warrants beneficially owned by certain
officers, directors, employees and related persons of the Reporting
Persons. The Reporting Persons disclaims beneficial ownership of such
shares beneficially owned by such parties.
<PAGE>
<PAGE>                                               Page 6 of 7 Pages      
             


Item 10.  Certification.

     By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired in the ordinary
course of business and were not acquired for the purpose of and do not have
the effect of changing or influencing the control of the issuer of such
securities and were not acquired in connection with or as a participant in
any transaction having such purposes or effect.
<PAGE>
<PAGE>                                               Page 7 of 7 Pages  




Signature:  After reasonable inquiry and to the best of our knowledge
and belief, we certify that the information set forth in this statement
is true, complete and correct.

Date:  February 11, 1998


ALLEN & COMPANY INCORPORATED


By:---------------------------                         
Name:  Gaetano J. Casillo
Title: Vice President


ALLEN HOLDING INC.


By:---------------------------                         
Name:  Gaetano J. Casillo
Title: Vice President



90752.2

<PAGE>
<PAGE>                                               Page 7 of 7 Pages  




Signature:  After reasonable inquiry and to the best of our knowledge
and belief, we certify that the information set forth in this statement
is true, complete and correct.

Date:  February 11, 1998
 

ALLEN & COMPANY INCORPORATED

       /x/ Gaetano J. Casillo
By:-----------------------------                       
Name:  Gaetano J. Casillo
Title: Vice President


ALLEN HOLDING INC.

       /x/ Gaetano J. Casillo
By:----------------------------                        
Name:  Gaetano J. Casillo
Title: Vice President
90752.2


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