APPLIED IMAGING CORP
SC 13G/A, 1998-02-17
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549


                                  SCHEDULE 13G


                   UNDER THE SECURITIES EXCHANGE ACT OF 1934

                              (AMENDMENT NO. ONE)*


                             Applied Imaging Corp.
- --------------------------------------------------------------------------------
                                (NAME OF ISSUER)


                    Common Stock, $0.001 par value per share
- --------------------------------------------------------------------------------
                         (TITLE OF CLASS OF SECURITIES)


                                  03820G 10 6
- --------------------------------------------------------------------------------
                                 (CUSIP NUMBER)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing of this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



SEC 1745 (2-95)

                               Page 1 of 5 Pages
<PAGE>
 
- -----------------------                                  ---------------------
 CUSIP NO. 03820G 10 6                13G                  PAGE 2 OF 5 PAGES
- -----------------------                                  ---------------------
 
- ------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
      
      Thompson Clive Investments plc

- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]
                                                                (b) [_]
                                                 
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
 

- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4    
      Jersey, Channel Islands, United Kingdom

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5   
     NUMBER OF            209,348
 
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          0
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7    
    REPORTING             209,348
 
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          0
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9  
      209,348

- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10                  
      Not Applicable
      
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11    
      2.7% (based on 7,667,956 shares of Common Stock outstanding
      as of December 31, 1997)                                      
- -------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      PN

- ------------------------------------------------------------------------------

                     *SEE INSTRUCTION BEFORE FILLING OUT
<PAGE>
 
  CUSIP No. 03820G 10 6                                        Page 3 of 5 Pages
            -----------

ITEM 1.

       (a)  Name of Issuer      Applied Imaging Corp.

       (b)  Address of Issuer's Principal Executive Offices
 
            2380 Walsh Avenue, Bldg, B, Santa Clara, CA  95051

ITEM 2.

       (a)  Name of Person Filing      Thompson Clive Investments plc

       (b)  Address of Principal Business Office or, if none, Residence
 
                28-34 Hill Street, St. Helier, Jersey, Channel Islands JE4 8NR

       (c)  Citizenship       Jersey resident
      
       (d)  Title of Class of Securities     Common Stock, $0.001 par value 
            per share
 
       (e)  CUSIP Number         03820G 10 6
 
ITEM 3.     IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b),
            CHECK WHETHER THE PERSON IS A:

       (a)  [_] Broker or Dealer registered under Section 15 of the Act

       (b)  [_] Bank as defined in section 3(a)(6) of the Act

       (c)  [_] Insurance Company as defined in section 3(a)(19) of the Act

       (d)  [_] Investment Company registered under section 8 of the Investment
                Company Act

       (e)  [_] Investment Adviser registered under section 203 of the
                Investment Advisers Act of 1940

       (f)  [_] Employee Benefit Plan, Pension Fund which is subject to the 
                provisions of the Employee Retirement Income Security Act of 
                1974 or Endowment Fund, see (S)240.13d-1(b)(1)(ii)(F)
 
       (g)  [_] Parent Holding Company, in accordance with (S)240.13d-
                1(b)(ii)(G) (Note: See Item 7)

       (h)  [_] Group, in accordance with (S)240.13d-1(b)(1)(ii)(H)
<PAGE>
 
 CUSIP No. 03820G 10 6                                        Page 4 of 5 Pages 
           -----------  
N/A -- The reporting person acquired all its shares prior to the registration of
the Issuer's shares pursuant to Section 12 of the Securities Exchange Act of
1934, as amended; therefore, this filing is pursuant to Rule 13d-1(c).

ITEM 4.  OWNERSHIP
       (a)  Amount Beneficially Owned 
 
       (b)  Percent of Class      

       (c)  Number of shares as to which such person has:

               (i)      sole power to vote or to direct the vote      
               (ii)     shared power to vote or to direct the vote          
               (iii)    sole power to dispose or direct the 
                        disposition of                               
               (iv)     shared power to dispose or direct the 
                        disposition of                                      


ITEM 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following  [x].


ITEM 6.   OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

Not Applicable

ITEM 7.   IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
          SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

Not Applicable

ITEM 8.   IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

Not Applicable

ITEM 9.   NOTICE OF DISSOLUTION OF GROUP

Not Applicable
<PAGE>
 
 CUSIP No. 03820G 10 6                                        Page 5 of 5 Pages 
           -----------
ITEM 10.

          By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired in the ordinary course of
business and were not acquired for the purpose of and do not have the effect of
changing or influencing the control of the issuer of such securities and were
not acquired in connection with or as a participant in any transaction having
such purposes or effect.


                                   SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

 
 
                                    February 17, 1998
                                    -----------------------------------------
                                                   Date


                                    /s/ Garrett C. McGonigal
                                    -----------------------------------------
                                                 Signature


                                    Garrett C. McGonigal, Attorney-in-Fact
                                    -----------------------------------------
                                                 Name/Title


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