APPLIED IMAGING CORP
8-K/A, 1999-05-07
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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<PAGE>
 
                     SECURITIES AND EXCHANGE COMMISSION
                           Washington, D.C. 20549


                                 Form 8-K/A


              Current Report Pursuant to Section 13 or 15(d) of
                     The Securities Exchange Act of 1934

 
       Date of Report (Date of earliest event reported): April 7, 1999



                            APPLIED IMAGING CORP.
           (Exact name of registrant as specified in its charter)


<TABLE> 
<S>                                      <C>                               <C>
           Delaware                              0-21371                               77-0120490
- -------------------------------          ------------------------          -------------------------------
(State or other jurisdiction of          (Commission File Number)          (I.R.S. Employer Identification
         incorporation)                                                                   No.)
</TABLE> 

                         2380 Walsh Avenue, Building B
                            Santa Clara, CA  95051
                   (Address of principal executive offices)

                                (408) 562-0250
             (Registrant's telephone number, including area code)
<PAGE>
 
Item 4.  Changes In Registrant's Certifying Accountants

         This amendment is being filed to file the letter from KPMG LLP
regarding a change in certifying accountants.


Item 7.  Financial Statements and Exhibits

         A.  Exhibits:

             Exhibit 16. Letter re change in certifying accountants.
<PAGE>
 
                                  SIGNATURES



     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report on Form 8-K/A to be signed on its behalf
by the undersigned hereunto duly authorized.



                                          Applied Imaging Corp.


Dated:  May 7, 1999                 By:   /s/ Jack Goldstein
                                          ------------------------------

                                          Jack Goldstein
                                          Chief Executive Officer
<PAGE>
 
                                 EXHIBIT INDEX



Exhibit 16   -   Letter regarding change in certifying accountants.

<PAGE>

                                                                      EXHIBIT 16
 
                             [KPMG LLP LETTERHEAD]



April 21, 1999


Securities and Exchange Commission
Washington, D.C. 20549

Ladies and Gentlemen:

We were previously principal accountants for Applied Imaging Corp. and, under
the date of February 5, 1999, we reported on the consolidated financial
statements of Applied Imaging Corp. and subsidiaries as of and for the years
ended December 31, 1998 and 1997.  On April 9, 1999, we were informed that our
appointment as principal accountants was terminated.  We have read Applied
Imaging Corp.'s statements included under Item 4 of its Form 8-K dated April 13,
1999, and we agree with such statements, except that we are not in a position to
agree or disagree with Applied Imaging Corp.'s statements included in the first
paragraph under Item 4.

Very truly yours,


/S/ KPMG LLP
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