APPLIED IMAGING CORP
SC 13G/A, 1999-02-16
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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                 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                SCHEDULE 13G

                   UNDER THE SECURITIES EXCHANGE ACT OF 1934
                             (AMENDMENT NO. 2)*

                            Applied Imaging Corp.
- --------------------------------------------------------------------------------
                              (Name of Issuer)


                        Common Stock, $.001 par value
- --------------------------------------------------------------------------------
                       (Title of Class of Securities)

                                03820G106
                     ----------------------------------
                              (CUSIP Number)


                             December 31, 1998
- -------------------------------------------------------------------------------
          (Date of Event Which Requires Filing of this Statement)


CHECK THE APPROPRIATE BOX TO DESIGNATE THE RULE PURSUANT TO WHICH THIS SCHEDULE
IS FILED:

/   /  Rule 13d-1(b)

/   /  Rule 13d-1(c)

/ x /  Rule 13d-1(d)


*The remainder of this cover page shall be filled out for a reporting 
person's initial filing on this form with respect to the subject class of 
securities, and for any subsequent amendment containing information which 
would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be 
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange 
Act of 1934 ("Act") or otherwise subject to the liabilities of that section 
of the Act but shall be subject to all other provisions of the Act (however, 
see the Notes).






                              Page 1 of 15 pages

<PAGE>

ITEM 1(a).  NAME OF ISSUER: Applied Imaging Corp.

ITEM 1(b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
            2380 Walsh Avenue, Building B, Santa Clara, CA 95051

ITEM 2(a).  NAMES OF PERSONS FILING: New Enterprise Associates V, Limited 
            Partnership ("NEA V"), New Enterprise Associates VII, Limited 
            Partnership ("NEA VII"), NEA Presidents' Fund, L.P. 
            ("Presidents") and The Silverado Fund I, Limited Partnership 
            ("Silverado") (collectively, the "Funds"); NEA Partners V, Limited
            Partnership ("NEA Partners V"), which is the sole general partner 
            of NEA V, NEA Partners VII, Limited Partnership ("NEA Partners 
            VII"), which is the sole general partner of NEA VII, NEA General 
            Partners, L.P. ("Presidents Partners"), which is the sole general 
            partner of Presidents, and NEA Silverado Partners I, Limited 
            Partnership ("Silverado Partners"), which is the sole general 
            partner of Silverado (collectively, the "GPLP's"); Peter J. Barris
            ("Barris"), Nancy L. Dorman ("Dorman"), Ronald H. Kase ("Kase"), 
            C. Richard Kramlich ("Kramlich"), Arthur J. Marks ("Marks"), 
            Thomas C. McConnell ("McConnell"), Peter T. Morris ("Morris"), 
            John M. Nehra ("Nehra"), Charles W. Newhall III ("Newhall") and 
            Mark W. Perry ("Perry"), (collectively, the "General Partners"); 
            Dorman, Kramlich, Marks, McConnell and Newhall are individual 
            general partners of NEA Partners V. Barris, Dorman, Kase, 
            Kramlich, Marks, McConnell, Morris, Nehra, Newhall and Perry are 
            individual general partners of NEA Partners VII. Barris, Dorman, 
            Kase, Kramlich, Marks, McConnell, Nehra, Newhall and Perry are 
            individual general partners of Presidents Partners. Kramlich, 
            Marks and Newhall are individual general partners of Silverado 
            Partners. The persons named in this paragraph are referred to 
            individually herein as a "Reporting Person" and collectively as 
            the "Reporting Persons."

ITEM 2(b).  ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE: The 
            address of the principal business office of NEA V, NEA Partners 
            V, NEA VII, NEA Partners VII, Presidents, Presidents Partners, 
            Silverado, Silverado Partners, Barris, Dorman, Marks, Morris, 
            Nehra, Newhall and Perry is New Enterprise Associates, 1119 St. 
            Paul Street, Baltimore, Maryland 21202. The address of the 
            principal business office of Kase, Kramlich and McConnell is New 
            Enterprise Associates, 2490 Sand Hill Road, Menlo Park, 
            California 94025.

ITEM 4.     OWNERSHIP.

            (a)   Amount Beneficially Owned: NEA V is the record owner of 
                  709,214 shares as of December 31, 1998 (the "NEA V 
                  Shares"). NEA VII is the record owner of 1,837,605 shares 
                  as of December 31, 1998 (the "NEA VII Shares"). Presidents is
                  the record owner of 15,920 shares as of December 31, 1998 
                  (the "Presidents' Shares"). Silverado is the record owner of
                  11,765 shares as of December 31, 1998 (the "Silverado 
                  Shares"). As the sole general partner of NEA V, NEA Partners V
                  may be deemed to own beneficially the NEA V Shares. As the 
                  sole general partner of NEA VII, NEA Partners VII may be 
                  deemed to own beneficially the NEA VII Shares. As the sole 
                  general partner of Presidents, Presidents Partners may be 
                  deemed to own beneficially the Presidents' Shares. As the 
                  sole general partner of Silverado, Silverado Partners may be
                  deemed to own beneficially the Silverado Shares. By virtue of
                  their relationship as affiliated limited partnerships, whose 
                  general partners have overlapping individual general partners,
                  each Fund may be deemed to share the power to direct the 
                  disposition and vote of the NEA V Shares, the NEA VII Shares,


                              Page 2 of 15 pages


<PAGE>


                  the Presidents' Shares and the Silverado Shares, for an 
                  aggregate of 2,574,504 shares (the "Record Shares"). As 
                  general partners of the Funds, each GPLP may also be deemed
                  to own beneficially the Record Shares. As general partners of
                  NEA Partners V, Dorman, Kramlich, Marks, McConnell and 
                  Newhall may be deemed to own beneficially the NEA V Shares. 
                  As general partners of NEA Partners VII, Barris, Dorman, Kase,
                  Kramlich, Marks, McConnell, Morris, Nehra, Newhall and Perry 
                  may be deemed to own beneficially the NEA VII Shares. As 
                  general partners of Presidents, Barris, Dorman, Kase, 
                  Kramlich, Marks, McConnell, Nehra, Newhall and Perry may be 
                  deemed to own beneficially the Presidents' Shares. As general
                  partners of Silverado, Kramlich, Marks and Newhall may be 
                  deemed to own beneficially the Silverado Shares. McConnell 
                  holds options to purchase 3,750 shares, which options are 
                  exercisable within 60 days after December 31, 1998. As a 
                  general partner of NEA Partners V, NEA Partners VII and 
                  Presidents Partners, McConnell may be deemed to own 
                  beneficially the NEA V Shares, the NEA VII Shares, the 
                  President's Shares and the 3,750 shares subject to his 
                  options, for a total of 2,566,489 shares.

            (b)   Percent of Class: The Funds, the GPLP's, Kramlich, Marks, 
                  McConnell and Newhall: 22.3%, Dorman: 22.2% and McConnell:
                  22.3%. Barris, Kase, Nehra and Perry: 16.1%, Morris: 16.0%.
                  The foregoing percentages are calculated based on the 
                  11,520,735 shares of Common Stock reported to be outstanding
                  in the Quarterly Report on Form 10-Q of Applied Imaging Corp.
                  for the fiscal quarter ended September 30, 1998, as adjusted
                  pursuant to Rule 13d-13(d)(1).

             (c)  Number of shares as to which such person has:

                  (i)   sole power to vote or to direct the vote: 0 shares 
                        for each Reporting Person other than McConnell, 3,750
                        shares for McConnell.

                 (ii)   shared power to vote or to direct the vote: 2,574,504 
                        shares for each of the Funds, each of the GPLP's, 
                        Kramlich, Marks and Newhall. 2,566,489 shares for 
                        McConnell, 2,562,739 shares for Dorman. 1,853,525 
                        shares for each of Barris, Kase, Nehra and Perry. 
                        1,837,650 shares for Morris.

                (iii)   sole power to dispose or to direct the disposition of:
                        0 shares for each Reporting Person other than 
                        McConnell. 3,750 shares for McConnell.

                 (iv)   shared power to dispose or to direct the disposition 
                        of: 2,574,504 shares for each of the Funds, each of 
                        the GPLP's, Kramlich, Marks and Newhall. 2,566,489 
                        shares for McConnell. 2,562,739 shares for Dorman. 
                        1,853,525 shares for each of Barris, Kase, Nehra and 
                        Perry. 1,837,650 shares for Morris.

Each Reporting Person disclaims beneficial ownership of such shares of Common 
Stock except for those shares, if any, such Reporting Person holds of record.



                              Page 3 of 15 pages


<PAGE>


ITEM 5.     OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

            Not Applicable.


ALL OTHER ITEMS REPORTED ON THE SCHEDULE 13G DATED AS OF FEBRUARY 10, 1998 
AND FILED ON BEHALF OF THE REPORTING PERSONS WITH RESPECT TO THE COMMON STOCK 
OF APPLIED IMAGING CORP. REMAIN UNCHANGED.






                              Page 4 of 15 pages

<PAGE>

                                  SIGNATURE

    After reasonable inquiry and to the best of its knowledge and belief, each 
of the undersigned certifies that the information set forth in this statement is
true, complete and correct.

Date:    February 10, 1999


NEW ENTERPRISE ASSOCIATES V, LIMITED PARTNERSHIP

By:   NEA PARTNERS V, LIMITED PARTNERSHIP

      By:               *
          ------------------------------------------
          Charles W. Newhall III
          General Partner

NEA PARTNERS V, LIMITED PARTNERSHIP

By:                     *
    ------------------------------------------------
    Charles W. Newhall III
    General Partner

NEW ENTERPRISE ASSOCIATES VII, LIMITED PARTNERSHIP

By: NEA Partners VII, Limited Partnership

    By:               *
       -----------------------------------
       Charles W. Newhall III
       General Partner


NEA PARTNERS VII, LIMITED PARTNERSHIP

By:                *
   --------------------------------------
   Charles W. Newhall III
   General Partner


NEA PRESIDENTS' FUND, L.P.

By: NEA GENERAL PARTNERS, L.P.

    By:               *
       -----------------------------------
       Charles W. Newhall III
       General Partner



                              Page 5 of 15 pages

<PAGE>

NEA GENERAL PARTNERS, L.P.

By:                 *
   ------------------------------------
   Charles W. Newhall III
   General Partner


THE SILVERADO FUND I, LIMITED PARTNERSHIP

By: NEA SILVERADO PARTNERS I, LIMITED PARTNERSHIP

    By:                  *
       --------------------------------------
       Charles W. Newhall III
       General Partner

NEA SILVERADO PARTNERS I, LIMITED PARTNERSHIP

By:                 *
   ------------------------------------
   Charles W. Newhall III
   General Partner


                 *
- ------------------------------------
Peter J. Barris


                 *
- ------------------------------------
Ronald H. Kase


                 *
- ------------------------------------
C. Richard Kramlich


                 *
- ------------------------------------
Arthur J. Marks


                 *
- ------------------------------------
Thomas C. McConnell


                 *
- ------------------------------------
Peter T. Morris


                 *
- ------------------------------------
John M. Nehra




                             Page 6 of 15 pages


<PAGE>


                 *
- ------------------------------------
Charles W. Newhall III


                 *
- ------------------------------------
Mark W. Perry



                                        *By:/s/ Nancy L. Dorman
                                            -----------------------------
                                            Nancy L. Dorman, in her individual
                                            capacity and as Attorney-in-Fact

- ------------------------------------------------------------------------------

This Schedule 13G was executed by Nancy L. Dorman pursuant to Powers of 
Attorney filed with the Securities and Exchange Commission on February 13, 
1992 in connection with a Schedule 13G for Advanced Interventional Systems 
Inc., on February 13, 1995 in connection with a Schedule 13G for Acuity 
Imaging, Inc., and herewith, which Powers of Attorney are incorporated herein 
by reference and copies of which are attached hereto as Exhibit 2.

                              Page 7 of 15 pages

<PAGE>


                                  AGREEMENT

    Pursuant to Rule 13d-1(f)(1) under the Securities Exchange Act of 1934, 
the undersigned hereby agree that only one statement containing the 
information required by Schedule 13G need be filed with respect to the 
ownership by each of the undersigned of shares of Common Stock of Applied 
Imaging Corp.

    EXECUTED as a sealed instrument this 10th day of February, 1999


NEW ENTERPRISE ASSOCIATES V, LIMITED PARTNERSHIP

By:   NEA PARTNERS V, LIMITED PARTNERSHIP

      By:               *
          ------------------------------------------
          Charles W. Newhall III
          General Partner


NEA PARTNERS V, LIMITED PARTNERSHIP

By:                     *
    ------------------------------------------------
    Charles W. Newhall III
    General Partner


NEW ENTERPRISE ASSOCIATES VII, LIMITED PARTNERSHIP

By: NEA Partners VII, Limited Partnership

    By:                     *
       -------------------------------------------------
       Charles W. Newhall III
       General Partner


NEA PARTNERS VII, LIMITED PARTNERSHIP

By:                     *
   -------------------------------------------------
   Charles W. Newhall III
   General Partner









                              Page 8 of 15 pages

<PAGE>


NEA PRESIDENTS' FUND, L.P.

By:  NEA GENERAL PARTNERS, L.P.

     By:                   *
        -----------------------------------------
        Charles W. Newhall III
        General Partner


NEA GENERAL PARTNERS, L.P.

By:                *
   ----------------------------------
   Charles W. Newhall III
   General Partner


THE SILVERADO FUND I, LIMITED PARTNERSHIP

By: NEA SILVERADO PARTNERS I, LIMITED PARTNERSHIP

    By:                *
        ----------------------------------
        Charles W. Newhall III
        General Partner


NEA SILVERADO PARTNERS I, LIMITED PARTNERSHIP

By:                *
   ----------------------------------
   Charles W. Newhall III
   General Partner





                              Page 9 of 15 pages


<PAGE>


               *
- -------------------------------
Peter J. Barris


               *
- -------------------------------
Ronald H. Kase


               *
- -------------------------------
C. Richard Kramlich


               *
- -------------------------------
Arthur J. Marks


               *
- -------------------------------
Thomas C. McConnell


               *
- -------------------------------
Peter T. Morris


               *
- -------------------------------
John M. Nehra


               *
- -------------------------------
Charles W. Newhall III


               *
- -------------------------------
Mark W. Perry



                                         *By: /s/ Nancy L. Dorman
                                             ----------------------------
                                             Nancy L. Dorman, in her individual
                                             capacity and as Attorney-in-Fact

- -------------------------------------------------------------------------------

This Agreement was executed by Nancy L. Dorman pursuant to Powers of Attorney 
filed with the Securities and Exchange Commission on February 13, 1992 in 
connection with a Schedule 13G for Advanced Interventional Systems Inc., on 
February 13, 1995 in connection with a Schedule 13G for Acuity Imaging, Inc., 
and herewith, which Powers of Attorney are incorporated herein by reference 
and copies of which are attached hereto as Exhibit 2.


                                       Page 10 of 15 pages


<PAGE>

                                                                     Exhibit 2


                               POWER OF ATTORNEY

   KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears 
below hereby constitutes and appoints Nancy L. Dorman and Charles W. Newhall 
III, and each of them, with full power to act without the other, his true and 
lawful attorney-in-fact, with full power of substitution, to sign any and all 
instruments, certificates and documents that may be necessary, desirable or 
appropriate to be executed on behalf of himself as an individual or in his 
capacity as a general partner of any partnership, pursuant to section 13 or 
16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), 
and any and all regulations promulgated thereunder, and to file the same, 
with all exhibits thereto, and any other documents in connection therewith, 
with the Securities and Exchange Commission, and with any other entity when 
and if such is mandated by the Exchange Act or by the By-laws of the National 
Association of Securities Dealers, Inc., granting unto said attorney-in-fact 
full power and authority to do and perform each and every act and thing 
necessary, desirable or appropriate, fully to all intents and purposes as he 
might or could do in person, thereby ratifying and confirming all that said 
attorney-in-fact, or his substitutes, may lawfully do or cause to be done by 
virtue hereof.

   IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 23rd 
day of April, 1991.


                                       /s/ Raymond L. Bank
                                       ------------------------------
                                       Raymond L. Bank

                                       /s/ Thomas R. Baruch
                                       ------------------------------
                                       Thomas R. Baruch

                                       /s/ Cornelius C. Bond, Jr.
                                       ------------------------------
                                       Cornelius C. Bond, Jr.

                                       /s/ Frank A. Bonsal, Jr.
                                       ------------------------------
                                       Frank A. Bonsal, Jr.

                                       /s/ James A. Cole
                                       ------------------------------
                                       James A. Cole




                             Page 11 of 15 pages


<PAGE>
                                       /s/ Nancy L. Dorman
                                       ------------------------------
                                       Nancy L. Dorman

                                       /s/ Neal M. Douglas
                                       ------------------------------
                                       Neal M. Douglas

                                       /s/ John W. Glynn, Jr.
                                       ------------------------------
                                       John W. Glynn, Jr.

                                       /s/ Curran W. Harvey
                                       ------------------------------
                                       Curran W. Harvey

                                       /s/ Ronald Kase
                                       ------------------------------
                                       Ronald Kase

                                       /s/ C. Richard Kramlich
                                       ------------------------------
                                       C. Richard Kramlich

                                       /s/ Robert F. Kuhling
                                       ------------------------------
                                       Robert F. Kuhling

                                       /s/ Arthur J. Marks
                                       ------------------------------
                                       Arthur J. Marks

                                       /s/ Thomas C. McConnell
                                       ------------------------------
                                       Thomas C. McConnell

                                       /s/ Donald L. Murfin
                                       ------------------------------
                                       Donald L. Murfin

                                       /s/ H. Leland Murphy
                                       ------------------------------
                                       H. Leland Murphy



                             Page 12 of 15 pages

<PAGE>

                                       /s/ John M. Nehra
                                       ------------------------------
                                       John M. Nehra

                                       /s/ Charles W. Newhall III
                                       ------------------------------
                                       Charles W. Newhall III

                                       /s/ Terry L. Opdendyk
                                       ------------------------------
                                       Terry L. Opdendyk

                                       /s/ Barbara J. Perrier
                                       ------------------------------
                                       Barbara J. Perrier

                                       /s/ C. Vincent Prothro
                                       ------------------------------
                                       C. Vincent Prothro

                                       /s/ C. Woodrow Rea, Jr.
                                       ------------------------------
                                       C. Woodrow Rea, Jr.

                                       /s/ Howard D. Wolfe, Jr.
                                       ------------------------------
                                       Howard D. Wolfe, Jr.

                                       /s/ Nora M. Zietz
                                       ------------------------------
                                       Nora M. Zietz



                             Page 13 of 15 pages

<PAGE>

                               POWER OF ATTORNEY

   KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears 
below hereby constitutes and appoints Nancy L. Dorman and Charles W. Newhall 
III, and each of them, with full power to act without the other, his true and 
lawful attorney-in-fact, with full power of substitution, to sign any and all 
instruments, certificates and documents that may be necessary, desirable or 
appropriate to be executed on behalf of himself as an individual or in his 
capacity as a general partner of any partnership, pursuant to section 13 or 
16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), 
and any and all regulations promulgated thereunder, and to file the same, 
with all exhibits thereto, and any other documents in connection therewith, 
with the Securities and Exchange Commission, and with any other entity when 
and if such is mandated by the Exchange Act or by the By-laws of the National 
Association of Securities Dealers, Inc., granting unto said attorney-in-fact 
full power and authority to do and perform each and every act and thing 
necessary, desirable or appropriate, fully to all intents and purposes as he 
might or could do in person, thereby ratifying and confirming all that said 
attorney-in-fact, or his substitutes, may lawfully do or cause to be done by 
virtue hereof.

   IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 1st 
day of January, 1994.


                                       /s/ Peter J. Barris
                                       ------------------------------
                                       Peter J. Barris


                                       /s/ Debra E. King
                                       ------------------------------
                                       Debra E. King


                                       /s/ Peter T. Morris
                                       ------------------------------
                                       Peter T. Morris


                                       /s/ Hugh Y. Rienhoff, Jr.
                                       ------------------------------
                                       Hugh Y. Rienhoff, Jr.


                                       /s/ Alexander Slusky
                                       ------------------------------
                                       Alexander Slusky


                                       /s/ Louis B. Van Dyck
                                       ------------------------------
                                       Louis B. Van Dyck



                             Page 14 of 15 pages

<PAGE>

                               POWER OF ATTORNEY

   KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears 
below hereby constitutes and appoints Nancy L. Dorman and Charles W. Newhall 
III, and each of them, with full power to act without the other, his true and 
lawful attorney-in-fact, with full power of substitution, to sign any and all 
instruments, certificates and documents that may be necessary, desirable or 
appropriate to be executed on behalf of himself as an individual or in his 
capacity as a general partner of any partnership, pursuant to section 13 or 
16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), 
and any and all regulations promulgated thereunder, and to file the same, 
with all exhibits thereto, and any other documents in connection therewith, 
with the Securities and Exchange Commission, and with any other entity when 
and if such is mandated by the Exchange Act or by the By-laws of the National 
Association of Securities Dealers, Inc., granting unto said attorney-in-fact 
full power and authority to do and perform each and every act and thing 
necessary, desirable or appropriate, fully to all intents and purposes as he 
might or could do in person, thereby ratifying and confirming all that said 
attorney-in-fact, or his substitutes, may lawfully do or cause to be done by 
virtue hereof.

   IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 10th 
day of February, 1999.


                                       /s/ Mark W. Perry
                                       ------------------------------
                                       Mark W. Perry

                                       /s/ Stewart Alsop II
                                       ------------------------------
                                       Stewart Alsop II






                             Page 15 of 15 pages







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