APPLIED IMAGING CORP
SC 13G/A, 2000-02-11
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 3 )*


                              Applied Imaging Corp.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.001 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    03820G106
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 1999
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

         Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

                [ ]   Rule 13d-1(b)
                [ ]   Rule 13d-1(c)
                [X]   Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>

ITEM 1(A).    NAME OF ISSUER: Applied Imaging Corp.

ITEM 1(B).    ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
              2380 Walsh Avenue, Building B, Santa Clara, CA 95051

ITEM 2(A).    NAMES OF PERSONS FILING: New Enterprise Associates V, Limited
              Partnership ("NEA V"), New Enterprise Associates VII, Limited
              Partnership ("NEA VII"), NEA Presidents' Fund, L.P. ("Presidents")
              and The Silverado Fund I, Limited Partnership ("Silverado")
              (collectively, the "Funds"); NEA Partners V, Limited Partnership
              ("NEA Partners V"), which is the sole general partner of NEA V,
              NEA Partners VII, Limited Partnership ("NEA Partners VII"), which
              is the sole general partner of NEA VII, NEA General Partners, L.P.
              ("Presidents Partners"), which is the sole general partner of
              Presidents, and NEA Silverado Partners I, Limited Partnership
              ("Silverado Partners"), which is the sole general partner of
              Silverado (collectively, the "GPLP's"); Peter J. Barris
              ("Barris"), Nancy L. Dorman ("Dorman"), Ronald H. Kase ("Kase"),
              C. Richard Kramlich ("Kramlich"), Arthur J. Marks ("Marks"),
              Thomas C. McConnell ("McConnell"), Peter T. Morris ("Morris"),
              John M. Nehra ("Nehra"), Charles W. Newhall III ("Newhall") and
              Mark W. Perry ("Perry"), (collectively, the "General Partners");
              Dorman, Kramlich, Marks, McConnell and Newhall are individual
              general partners of NEA Partners V. Barris, Dorman, Kase,
              Kramlich, Marks, McConnell, Morris, Nehra, Newhall and Perry are
              individual general partners of NEA Partners VII. Barris, Dorman,
              Kase, Kramlich, Marks, McConnell, Nehra, Newhall and Perry are
              individual general partners of Presidents Partners. Kramlich,
              Marks and Newhall are individual general partners of Silverado
              Partners. The persons named in this paragraph are referred to
              individually herein as a "Reporting Person" and collectively as
              the "Reporting Persons."

ITEM 2(B).    ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
              The address of the principal business office of NEA V, NEA
              Partners V, NEA VII, NEA Partners VII, Presidents, Presidents
              Partners, Silverado, Silverado Partners, Dorman, Marks, Morris,
              Nehra, Newhall and Perry is New Enterprise Associates, 1119 St.
              Paul Street, Baltimore, Maryland 21202. The address of the
              principal business office of Kase, Kramlich and McConnell is New
              Enterprise Associates, 2490 Sand Hill Road, Menlo Park, California
              94025. The address of the principal business office of Barris is
              New Enterprise Associates, 11911 Freedom Drive, One Fountain
              Square, Suite 580, Reston, Virginia 20190.

ITEM 4.       OWNERSHIP.
              (a)    Amount Beneficially Owned: NEA V is the record owner of
                     709,214 shares as of December 31, 1999 (the "NEA V
                     Shares"). NEA VII is the record owner of 1,837,605 shares
                     as of December 31, 1999 (the "NEA VII Shares"). Presidents
                     is the record owner of 15,920 shares as of December 31,
                     1999 (the "Presidents' Shares"). Silverado is the record
                     owner of 11,765 shares as of December 31, 1999 (the
                     "Silverado Shares"). As the sole general partner of NEA V,
                     NEA Partners V may be deemed to own beneficially the NEA V
                     Shares. As the sole general partner of NEA VII, NEA
                     Partners VII may be deemed to own
<PAGE>

                     beneficially the NEA VII Shares. As the sole general
                     partner of Presidents, Presidents Partners may be deemed to
                     own beneficially the Presidents' Shares. As the sole
                     general partner of Silverado, Silverado Partners may be
                     deemed to own beneficially the Silverado Shares. By virtue
                     of their relationship as affiliated limited partnerships,
                     whose general partners have overlapping individual general
                     partners, each Fund may be deemed to share the power to
                     direct the disposition and vote of the NEA V Shares, the
                     NEA VII Shares, the Presidents' Shares and the Silverado
                     Shares, for an aggregate of 2,574,504 shares (the "Record
                     Shares"). As general partners of the Funds, each GPLP may
                     also be deemed to own beneficially the Record Shares. As
                     general partners of NEA Partners V, NEA Partners VII,
                     Presidents Partners and Siverado Partners, Kramlich, Marks
                     and Newhall may be deemed to own beneficially the Record
                     Shares. As general partners of NEA Partners VII, Barris,
                     Kase, Nehra, and Perry may be deemed to own beneficially
                     the NEA V Shares and the NEA VII Shares. As an individual
                     general partner of Presidents, Dorman, may be deemed to own
                     beneficially the NEA V Shares, the NEA VII Shares and the
                     Presidents' Shares. As an individual general partner of NEA
                     Partners VIII, Morris may be deemed to own beneficially the
                     NEA VII Shares. McConnell holds options to purchase 7,500
                     shares (the "Option Shares"), which options are exercisable
                     within 60 days after December 31, 1999. As a general
                     partner of NEA Partners V, NEA Partners VII and Presidents
                     Partners, McConnell may be deemed to own beneficially the
                     NEA V Shares, the NEA VII Shares, the President's Shares
                     and the Option Shares, for a total of 2,570,239 shares.

              (b)    Percent of Class: The Funds, the GPLP's, Kramlich, Marks
                     and Newhall: 21.4%. Dorman and McConnell: 21.3%. Barris,
                     Kase, Nehra and Perry: 15.4%. Morris: 15.2%. The foregoing
                     percentages are calculated based on the 12,054,512 shares
                     of Common Stock reported to be outstanding as of November
                     8, 1999, as adjusted pursuant to Rule 13d-13(d)(1).

              (c)    Number of shares as to which such person has:

                   (i)  sole power to vote or to direct the vote: 0 shares for
                        each Reporting Person other than McConnell. 7,500 shares
                        for McConnell.

                  (ii)  shared power to vote or to direct the vote: 2,574,504
                        shares for each of the Funds, each of the GPLP's,
                        Kramlich, Marks and Newhall. 2,570,239 shares for
                        McConnell. 2,562,739 shares for Dorman. 1,853,525 shares
                        for each of Barris, Kase, Nehra and Perry. 1,837,605
                        shares for Morris.

                 (iii)  sole power to dispose or to direct the disposition of: 0
                        shares for each Reporting Person other than McConnell.
                        7,500 shares for McConnell.

                  (iv)  shared power to dispose or to direct the disposition of:
                        2,574,504 shares for each of the Funds, each of the
                        GPLP's, Kramlich, Marks and Newhall. 2,570,239 shares
                        for McConnell. 2,562,739 shares for Dorman.
<PAGE>

                        1,853,525 shares for each of Barris, Kase, Nehra and
                        Perry. 1,837,605 shares for Morris.

              Each Reporting Person disclaims beneficial ownership of such
              shares of Common Stock except for those shares, if any, such
              Reporting Person holds of record.

ITEM 5.       OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
              Not Applicable.


ALL OTHER ITEMS REPORTED ON THE SCHEDULE 13G DATED AS OF FEBRUARY 16, 1999 AND
FILED ON BEHALF OF THE REPORTING PERSONS WITH RESPECT TO THE COMMON STOCK OF
APPLIED IMAGING CORP. REMAIN UNCHANGED.
<PAGE>


                                    SIGNATURE
                                    ---------

      After reasonable inquiry and to the best of its knowledge and belief, each
of the undersigned certifies that the information set forth in this statement is
true, complete and correct.

Date: January 25, 2000


NEW ENTERPRISE ASSOCIATES V, LIMITED PARTNERSHIP

By:   NEA PARTNERS V, LIMITED PARTNERSHIP

      By:            *
              ----------------------
              Charles W. Newhall III
              General Partner


NEA PARTNERS V, LIMITED PARTNERSHIP

By:           *
      -----------------------
      Charles W. Newhall III
      General Partner


NEW ENTERPRISE ASSOCIATES VII, LIMITED PARTNERSHIP

By:   NEA Partners VII, Limited Partnership

      By:             *
              ----------------------
              Charles W. Newhall III
              General Partner


NEA Partners VII, Limited Partnership

By:          *
      -----------------------
      Charles W. Newhall III
      General Partner

NEA PRESIDENTS' FUND, L.P.

By:   NEA GENERAL PARTNERS, L.P.

      By:            *
              ----------------------
              Charles W. Newhall III
              General Partner


<PAGE>


NEA GENERAL PARTNERS, L.P.

By:          *
      -----------------------
      Charles W. Newhall III
      General Partner


THE SILVERADO FUND I, LIMITED PARTNERSHIP

By:   NEA SILVERADO PARTNERS I, LIMITED PARTNERSHIP

      By:            *
              ----------------------
              Charles W. Newhall III
              General Partner

NEA SILVERADO PARTNERS I, LIMITED PARTNERSHIP

By:                       *
      ---------------------
      Charles W. Newhall III
      General Partner


         *
- -------------------------------
Peter J. Barris


         *
- -------------------------------
Cornelius C. Bond, Jr.


         *
- -------------------------------
Frank A. Bonsal, Jr.


         *
- -------------------------------
Ronald H. Kase


         *
- -------------------------------
C. Richard Kramlich


         *
- -------------------------------
Arthur J. Marks


         *
- -------------------------------
Thomas C. McConnell
<PAGE>

         *
- -------------------------------
Peter T. Morris


         *
- -------------------------------
John M. Nehra


         *
- -------------------------------
Charles W. Newhall III


         *
- -------------------------------
Mark W. Perry


                                       *By:   /s/ Nancy L. Dorman
                                              -------------------
                                              Nancy L. Dorman, in her individual
                                              capacity and as Attorney-in-Fact
- --------------------------------------------------------------------------------

This Schedule 13G was executed by Nancy L. Dorman pursuant to Powers of Attorney
filed with the Securities and Exchange Commission on February 13, 1992 in
connection with a Schedule 13G for Advanced Interventional Systems Inc., on
February 13, 1995 in connection with a Schedule 13G for Acuity Imaging, Inc.,
and herewith, which Powers of Attorney are incorporated herein by reference and
copies of which are attached hereto as Exhibit 1.


                                                                      EXHIBIT 1
                                                                      ---------
                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below hereby constitutes and appoints Nancy L. Dorman and Charles W.
Newhall III, and each of them, with full power to act without the other, his
true and lawful attorney-in-fact, with full power of substitution, to sign any
and all instruments, certificates and documents that may be necessary, desirable
or appropriate to be executed on behalf of himself as an individual or in his
capacity as a general partner of any partnership, pursuant to section 13 or 16
of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any
and all regulations promulgated thereunder, and to file the same, with all
exhibits thereto, and any other documents in connection therewith, with the
Securities and Exchange Commission, and with any other entity when and if such
is mandated by the Exchange Act or by the By-laws of the National Association of
Securities Dealers, Inc., granting unto said attorney-in-fact full power and
authority to do and perform each and every act and thing necessary, desirable or
appropriate, fully to all intents and purposes as he might or could do in
person, thereby ratifying and confirming all that said attorney-in-fact, or his
substitutes, may lawfully do or cause to be done by virtue hereof.

         IN WITNESS WHEREOF, this Power of Attorney has been signed as of the
23rd day of April, 1991.


                                                     /s/ Raymond L. Bank
                                                     ---------------------------
                                                     Raymond L. Bank


                                                     /s/ Thomas R. Baruch
                                                     ---------------------------
                                                     Thomas R. Baruch


                                                     /s/ Cornelius C. Bond, Jr.
                                                     ---------------------------
                                                     Cornelius C. Bond, Jr.


                                                     /s/ Frank A. Bonsal, Jr.
                                                     ---------------------------
                                                     Frank A. Bonsal, Jr.


                                                     /s/ James A. Cole
                                                     ---------------------------
                                                     James A. Cole

<PAGE>

                                                     /s/ Nancy L. Dorman
                                                     ---------------------------
                                                     Nancy L. Dorman


                                                     /s/ Neal M. Douglas
                                                     ---------------------------
                                                     Neal M. Douglas


                                                     /s/ John W. Glynn, Jr.
                                                     ---------------------------
                                                     John W. Glynn, Jr.


                                                     /s/ Curran W. Harvey
                                                     ---------------------------
                                                     Curran W. Harvey


                                                     /s/ Ronald Kase
                                                     ---------------------------
                                                     Ronald Kase


                                                     /s/ C. Richard Kramlich
                                                     ---------------------------
                                                     C. Richard Kramlich


                                                     /s/ Robert F. Kuhling
                                                     ---------------------------
                                                     Robert F. Kuhling


                                                     /s/ Arthur J. Marks
                                                     ---------------------------
                                                     Arthur J. Marks


                                                     /s/ Thomas C. McConnell
                                                     ---------------------------
                                                     Thomas C. McConnell


                                                     /s/ Donald L. Murfin
                                                     ---------------------------
                                                     Donald L. Murfin


                                                     /s/ H. Leland Murphy
                                                     ---------------------------
                                                     H. Leland Murphy
<PAGE>

                                                     /s/ John M. Nehra
                                                     ---------------------------
                                                     John M. Nehra


                                                     /s/ Charles W. Newhall III
                                                     ---------------------------
                                                     Charles W. Newhall III


                                                     /s/ Terry L. Opdendyk
                                                     ---------------------------
                                                     Terry L. Opdendyk


                                                     /s/ Barbara J. Perrier
                                                     ---------------------------
                                                     Barbara J. Perrier


                                                     /s/ C. Vincent Prothro
                                                     ---------------------------
                                                     C. Vincent Prothro


                                                     /s/ C. Woodrow Rea, Jr.
                                                     ---------------------------
                                                     C. Woodrow Rea, Jr.


                                                     /s/ Howard D. Wolfe, Jr.
                                                     ---------------------------
                                                     Howard D. Wolfe, Jr.


                                                     /s/ Nora M. Zietz
                                                     ---------------------------
                                                     Nora M. Zietz
<PAGE>

                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below hereby constitutes and appoints Nancy L. Dorman and Charles W.
Newhall III, and each of them, with full power to act without the other, his
true and lawful attorney-in-fact, with full power of substitution, to sign any
and all instruments, certificates and documents that may be necessary, desirable
or appropriate to be executed on behalf of himself as an individual or in his
capacity as a general partner of any partnership, pursuant to section 13 or 16
of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any
and all regulations promulgated thereunder, and to file the same, with all
exhibits thereto, and any other documents in connection therewith, with the
Securities and Exchange Commission, and with any other entity when and if such
is mandated by the Exchange Act or by the By-laws of the National Association of
Securities Dealers, Inc., granting unto said attorney-in-fact full power and
authority to do and perform each and every act and thing necessary, desirable or
appropriate, fully to all intents and purposes as he might or could do in
person, thereby ratifying and confirming all that said attorney-in-fact, or his
substitutes, may lawfully do or cause to be done by virtue hereof.

         IN WITNESS WHEREOF, this Power of Attorney has been signed as of the
1st day of January, 1994.

                                                     /s/ Peter J. Barris
                                                     ---------------------------
                                                     Peter J. Barris


                                                     /s/ Debra E. King
                                                     ---------------------------
                                                     Debra E. King


                                                     /s/ Peter T. Morris
                                                     ---------------------------
                                                     Peter. T. Morris


                                                     /s/ Hugh Y. Rienhoff, Jr.
                                                     ---------------------------
                                                     Hugh Y. Rienhoff, Jr.


                                                     /s/ Alexander Slusky
                                                     ---------------------------
                                                     Alexander Slusky


                                                     /s/ Louis B. Van Dyck
                                                     ---------------------------
                                                     Louis B. Van Dyck

<PAGE>


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below hereby constitutes and appoints Nancy L. Dorman and Charles W.
Newhall III, and each of them, with full power to act without the other, his
true and lawful attorney-in-fact, with full power of substitution, to sign any
and all instruments, certificates and documents that may be necessary, desirable
or appropriate to be executed on behalf of himself as an individual or in his
capacity as a general partner of any partnership, pursuant to section 13 or 16
of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any
and all regulations promulgated thereunder, and to file the same, with all
exhibits thereto, and any other documents in connection therewith, with the
Securities and Exchange Commission, and with any other entity when and if such
is mandated by the Exchange Act or by the By-laws of the National Association of
Securities Dealers, Inc., granting unto said attorney-in-fact full power and
authority to do and perform each and every act and thing necessary, desirable or
appropriate, fully to all intents and purposes as he might or could do in
person, thereby ratifying and confirming all that said attorney-in-fact, or his
substitutes, may lawfully do or cause to be done by virtue hereof.

         IN WITNESS WHEREOF, this Power of Attorney has been signed as of the
10th day of February, 1999.


                                                     /s/ Mark W. Perry
                                                     ---------------------------
                                                     Mark W. Perry


                                                     /s/ Stewart Alsop II
                                                     ---------------------------
                                                     Stewart Alsop II



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