CELGENE CORP /DE/
10-Q, 1995-08-14
INDUSTRIAL ORGANIC CHEMICALS
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<PAGE>

                                   FORM 10-Q

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.20549


(Mark one)

[x]      QUARTERLY  REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES  EXCHANGE
         ACT OF 1934

For the quarterly period ended June 30, 1995

                                       OR

[ ]      TRANSITION  REPORT  PURSUANT  TO SECTION 13 OR 15(d) OF THE  SECURITIES
         EXCHANGE ACT OF 1934

For the transition period from                    to
                               --------------         -----------------------

Commission File Number 0-16132

                              CELGENE CORPORATION
             (Exact name of registrant as specified in its charter)


           Delaware                                   22-2711928
-------------------------------                   -------------------
(State or other jurisdiction of                    (I.R.S. Employer
incorporation or organization)                    Identification No.)

7 Powder Horn Drive, Warren, New Jersey                           07059
---------------------------------------                         ----------
(Address of principal executive offices)                        (Zip Code)

Registrant's telephone number, including area code: 908-271-1001

         Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days.

                               Yes   X      No
                                   -----       -----

         At July 31, 1995,  7,862,689 shares of Common Stock, par value
         $.01 per share, were issued and outstanding.




                                       1

<PAGE>



                              CELGENE CORPORATION

                               INDEX TO FORM 10-Q



PART I - FINANCIAL INFORMATION

<TABLE>
<CAPTION>
                                                                       Page No.
                                                                       --------
<S>          <C>                                                          <C>
     Item 1  Condensed Financial Statements   

             Balance Sheets as of June 30, 1995
             and December 31, 1994                                         3

             Statements of Operations - 
             Three-Month Periods Ended June 30, 1995
             and 1994                                                      4

             Statements of Operations -
             Six-Month Periods Ended June 30, 1995 
             and 1994                                                      5

             Statements of Cash Flows -
             Six-Month Periods Ended
             June 30, 1995 and 1994                                        6

             Notes to Unaudited Condensed
             Financial Statements                                          7


     Item 2  Management's Discussion and Analysis
             of Financial Condition and Results
             of Operations                                                 9

PART II - OTHER INFORMATION                                               12

     Signatures                                                           13


</TABLE>


                                       2


<PAGE>


PART I - FINANCIAL INFORMATION
Item 1 - Condensed Financial Statements

                              CELGENE CORPORATION
                                 BALANCE SHEETS

                                     ASSETS

<TABLE>
<CAPTION>
                                                                                                       June 30         December 31
                                                                                                      ---------        -----------
                                                                                                         1995               1994
                                                                                                         ----               ----
                                                                                                     (Unaudited)
<S>                                                                                                 <C>                <C>         
Current assets:     
    Cash and cash equivalents                                                                       $    896,874       $    292,925
Marketable securities available
       for sale                                                                                        4,012,155          8,207,161
    Accounts receivable                                                                                  321,313            623,084
    Other current assets                                                                                 480,167            428,844
                                                                                                    ------------       ------------
          Total current assets                                                                         5,710,509          9,552,014

Plant and equipment, net                                                                               1,575,906          1,954,666

Other assets                                                                                              41,250             41,250
                                                                                                    ------------       ------------
                                                                                                    $  7,327,665       $ 11,547,930
                                                                                                    ============       ============

                      LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
    Accounts payable                                                                                $    200,682       $    439,189
    Accrued expenses                                                                                   1,409,454          1,104,675
                                                                                                    ------------       ------------
          Total current liabilities                                                                    1,610,136          1,543,864
                                                                                                    ------------       ------------

Stockholders' equity:
    Preferred stock, par value $.01
       per share. Authorized 5,000,000
       shares; issued none                                                                                  --                 --
    Common stock, par value $.01 per share. Authorized 20,000,000 shares; issued
       and outstanding 7,862,689 shares at June 30, 1995 and December 31, 1994,
       respectively                                                                                       78,627             78,627
Additional paid-in capital                                                                            70,684,768         70,684,768
Unamortized deferred compensation -
       restricted stock                                                                                  (12,186)           (19,174)
Accumulated deficit                                                                                  (64,876,473)       (60,472,877)
Net unrealized loss on marketable
    securities available for sale                                                                       (157,207)          (267,278)
                                                                                                    ------------       ------------
Total stockholders' equity                                                                             5,717,529         10,004,066
                                                                                                    ------------       ------------
                                                                                                    $  7,327,665       $ 11,547,930
                                                                                                    ============       ============
</TABLE>

                                       3

<PAGE>


                              CELGENE CORPORATION
                            STATEMENTS OF OPERATIONS
                                  (Unaudited)

<TABLE>
<CAPTION>
                                              Three-Month Period Ended June 30
                                              ---------------------------------
                                                   1995                1994
                                                  ------              ------
<S>                                             <C>                <C>         
Revenues:
    Sales of chemical
    intermediates                               $    223,550       $    615,845
    Research contracts                               100,000             20,000
    Investment income                                 80,350            115,004
                                                ------------       ------------ 
                                                     403,900            750,849
                                                ------------       ------------ 


Expenses:

    Cost of goods sold                               203,549            304,073
    Research and development                       1,768,222          1,604,072
    Selling, general and
     administrative                                  689,143            854,624
                                                ------------       ------------ 
                                                   2,660,914          2,762,769
                                                ------------       ------------ 
Loss from continuing
 operations                                       (2,257,014)        (2,011,920)

Discontinued operations
    Loss from operations                                --             (729,421)
    Loss on disposal                                    --             (839,000)
                                                ------------       ------------ 
Loss from discontinued
 operation                                              --           (1,568,421)
                                                ------------       ------------ 
Net loss                                        ($ 2,257,014)      ($ 3,580,341)
                                                ============       ============ 


Per share of Common Stock

    Loss from continuing
     operations                                       ($ .29)            ($ .26)

    Loss from discontinued
     operation                                          --                 (.20)
                                                      ------             ------
Net loss                                              ($ .29)            ($ .46)
                                                      ======             ====== 


Weighted average number
    of shares of common stock
    outstanding                                    7,863,000          7,843,000
                                                   =========          =========
</TABLE>



                                       4

<PAGE>


                              CELGENE CORPORATION
                            STATEMENTS OF OPERATIONS
                                  (Unaudited)


<TABLE>
<CAPTION>
                                     Six-Month Period Ended June 30
                                     ------------------------------
                                          1995          1994
                                          ----          ----

<S>                                   <C>            <C>         
Revenues:
    Sales of chemical
    intermediates                     $    242,138   $    994,441
    Research contracts                     240,000         45,000
    Investment income                      188,740        273,467
                                      ------------   ------------
                                           670,878      1,312,908
                                      ------------   ------------
Expenses:

    Cost of goods sold                     363,926        521,098
    Research and development             3,346,294      2,966,329
    Selling, general and
     administrative                      1,364,254      1,743,907
                                      ------------   ------------
                                         5,074,474      5,231,334
                                      ------------   ------------
Loss from continuing
 operations                             (4,403,596)    (3,918,426)

Discontinued operations
    Loss from operations                      --       (1,497,088)
    Loss on disposal                          --       (  839,000)
                                      ------------   ------------
Loss from discontinued
 operation                                    --       (2,336,088)
                                      ------------   ------------
Net loss                              ($ 4,403,596)  ($ 6,254,514)
                                      ============   ============ 


Per share of Common Stock

    Loss from continuing
     operations                             ($ .56)        ($ .50)

    Loss from discontinued
     operation                                --            ( .30)
                                             -----          -----

Net loss                                    ($ .56)         ($ .80)
                                            ======          ====== 


Weighted average number
    of shares of common stock
    outstanding                          7,863,000      7,843,000
                                         =========      =========
</TABLE>



                                       5

<PAGE>



                              CELGENE CORPORATION
                            STATEMENTS OF CASH FLOWS
                                  (Unaudited)

<TABLE>
<CAPTION>

                                                 Six-Month Period Ended June 30,
                                                 -------------------------------
                                                          1995        1994
                                                          ----        ----
<S>                                                 <C>            <C>          
Cash flows from operating activities:
Loss from continuing operations                     ($ 4,403,596)  ($ 3,918,426)
Adjustments to reconcile loss from continuing
 operations to net cash used in operating
 activities:
     Depreciation and amortization                       388,006        332,126
     Amortization of deferred compensation                 6,988         28,885
     (Decrease) increase in accounts payable
         and accrued expenses                             66,272         21,524
     Decrease in accounts receivable                     301,771         75,532
     Increase in other assets                            (51,323)      (335,441)
                                                      ----------     ----------
       Net cash used in continuing operations         (3,691,882)    (3,795,800)
                                                      ----------     ----------
       Net cash used in discontinued operation              --       (1,736,054)
                                                      ----------     ----------
       Net cash used in operating activities          (3,691,882)    (5,531,854)
                                                      ----------     ----------

Cash flows from investing activities:
 Continuing operations:
     Capital expenditures                                 (9,246)      (198,964)
     Proceeds from sales and maturities
       of marketable securities available
       for sale                                        4,827,327     15,296,989
     Purchases of marketable securities
     available for sale                                 (522,250)    (9,379,646)
                                                      ----------     ----------
       Net cash provided by investing
         activities                                    4,295,831      5,718,379
                                                      ----------     ----------

Cash flows from financing activities:
     Net proceeds from sale of common stock                 --            4,417
                                                      ----------     ----------

Net increase in cash and cash
  equivalents                                       $    603,949        190,942
Cash and cash equivalents at
    beginning of period                                  292,925        789,847
                                                      ----------     ----------
Cash and cash equivalents at end of period          $    896,874   $    980,789
                                                      ----------     ----------
                                                      ----------     ----------


Net increase in cash and
  cash equivalents                                       603,949   $    190,942
Decrease in marketable securities
  available for sale                                  (4,305,077)    (5,917,343)
                                                      ----------     ----------
Net decrease in cash and cash equivalents
    and marketable securities available
    for sale                                        ($ 3,701,128)  ($ 5,726,401)
                                                      ==========     ==========

Non-cash investing activity - net change
gain (loss) in net unrealized loss on
securities available for sale                       $    110,071   ($   146,395)
                                                      ==========     ==========

</TABLE>

                                       6


<PAGE>


                              CELGENE CORPORATION
               Notes to Unaudited Condensed Financial Statements
                                 June 30, 1995

1. Basis of Presentation

     The unaudited  financial  statements  have been prepared from the books and
records of Celgene  Corporation  (the  'Company') in accordance  with  generally
accepted  accounting  principles for interim financial  information  pursuant to
Rule  10-01 of  Regulation  S-X.  Accordingly,  they do not  include  all of the
information and footnotes required by generally accepted  accounting  principles
for complete financial statements.

     In the opinion of management,  all adjustments  (consisting  only of normal
recurring  accruals)  considered  necessary  for a fair  presentation  have been
included.  Interim  results may not be  indicative  of the  results  that may be
expected for the year.

     Where appropriate prior period financial  information has been reclassified
to conform to the 1995 presentation.

2. Stock Options

     On June  16,  1995,  the  stockholders  of the  Company  approved  the 1995
Non-Employee  Directors'  Incentive  Plan,  which  provides  for the granting of
non-qualified  stock  options to purchase an  aggregate of not more than 250,000
shares of common stock (subject to adjustment  under certain  circumstances)  to
directors  of the  Company  who are not  officers  or  employees  of the Company
('Non-Employee Directors'). Each new Non-Employee Director, upon the date of his
election or appointment,  receives an option to purchase 20,000 shares of common
stock. Additionally,  upon the date of each annual meeting of stockholders, each
continuing Non-Employee Director receives an option to purchase 10,000 shares of
common  stock (or a pro rata  portion  thereof  if he has  served  less than one
year),  except that at the 1995 annual meeting of stockholders  the Non-Employee
Directors  received an option to purchase 6,000 shares of common stock. On April
5,  1995,  each   Non-Employee   Director  was  granted,   under  this  plan,  a
non-qualified  option to  purchase  20,000  shares of common  stock,  subject to
stockholder approval which was received on June 16, 1995.

     The shares  subject to each  option  grant of 20,000  shares  vests in four
equal annual  installments  commencing on the first  anniversary  of the date of
grant.  The shares subject to an annual meeting option grant vest in full on the
date of the first annual  meeting of  stockholders  held  following  the date of
grant.

     All options are granted at fair market  value and expire 10 years after the
date of  grant.  This  plan  terminates  in 2005 and no  additional  options  or
restricted  stock awards may be granted  under the Company's  1992  Non-Employee
Directors' Stock Option Plan.

                                       7

<PAGE>

                              CELGENE CORPORATION
        Notes to Unaudited Condensed Financial Statements -- (continued)

3. Subsequent Event

     Subsequent to the second  quarter ended June 30, 1995,  the Company  issued
and sold in a private placement offering, 8% convertible debentures due July 31,
1997  in the  aggregate  principal  amount  of  $12,000,000,  and  received  net
proceeds,  after offering costs, of approximately  $11,000,000.  Such debentures
are  convertible  into  common  stock of the Company at the option of either the
holders thereof or the Company.  The holders of the  convertible  debentures may
convert the debentures into common stock of the Company at $8.00 per share until
September 12, 1995,  after which time the  conversion  price varies and is based
upon  the  market  price  (as  defined)  of the  common  stock  on the  date  of
conversion.

     The  Company  may  require the  conversion  of the  convertible  debentures
commencing  October 15, 1995 through  July 30, 1997 at a conversion  price which
varies  and is based upon the  market  price of the common  stock on the date of
conversion.  The Company also has the right to redeem any convertible  debenture
after it has received a notice of conversion with respect to such debenture. The
redemption price is the greater of 115% of the principal and accrued interest of
the redeemed  debenture and an amount which is based on the  appreciation of the
common stock from issuance of the debentures.

     The conversion price of the convertible debentures is subject to adjustment
under certain circumstances.


                                       8


<PAGE>


PART I - FINANCIAL INFORMATION
Item 2 - Management's Discussion and Analysis of
         Financial Condition and Results of Operations

Liquidity and Capital Resources

     On  June  30,  1995,   the  Company  had  available   working   capital  of
approximately  $4,100,000,  consisting principally of cash, cash equivalents and
marketable  securities  available  for sale,  which  represents  a  decrease  of
approximately  $3,908,000,  or 49%,  from  December  31, 1994  primarily  due to
operating losses.

     Subsequent  to June 30,  1995,  the  Company  issued  and sold in a private
placement  offering,   an  aggregate  principal  amount  of  $12,000,000  of  8%
convertible  debentures  due July 31, 1997,  and received  net  proceeds,  after
offering  costs,  of  approximately  $11,000,000.  The proceeds from the sale of
these debentures  increased the Company's working capital (on a pro forma basis)
to  approximately  $15,100,000 as of June 30, 1995. (See Note 2 to the Unaudited
Condensed Financial Statements)

     In  August  1992,  the  Company  entered  into  a  two-year   research  and
development  agreement  with  the  Rockefeller  University.  In July  1994  this
agreement was extended for an additional two years.  Under terms of the contract
extension,  the Company is committed to an annual fee to Rockefeller  University
of $504,000 paid semiannually in April and October.

     The Company's financial  statements for the six-month period ended June 30,
1995  have  been  prepared  on a going  concern  basis  which  contemplates  the
realization of assets and the settlement of liabilities  and  commitments in the
normal course of business. The Company incurred a net loss of $4,404,000 for the
six  months  ended  June 30,  1995 and as of June  30,  1995 had an  accumulated
deficit of $64,876,000. The Company expects to incur substantial expenditures to
further its  immunotherapeutic  program and to expand its chiral  business.  The
Company's  working  capital at June 30, 1995 and proceeds  from the  convertible
debenture  offering  plus  limited  revenue  from  product  sales  and  research
contracts  from  its  chiral  business  will  not be  sufficient  to  meet  such
objectives as presently structured.  Management recognizes that the Company must
generate additional resources or consider modifications to its immunotherapeutic
program  or other  reductions  in  operating  costs  to  enable  it to  continue
operations with available resources. Management's plans include consideration of
the sale of additional securities under appropriate market conditions, alliances
or other  partnership  agreements  with entities  interested in and resources to
support the Company's  immunotherapeutic  or chiral programs,  or other business
transactions which would generate sufficient resources to assure continuation of
the Company's operations and research programs.


     The Company has  retained  investment  banking  counsel to advise it on the
possible sale of securities as well as to introduce and assist in the evaluation
of potential merger and partnering


                                       9


<PAGE>

opportunities.  The Company also has retained independent  consultants to assist
it to identify other  entities  interested in its  immunotherapeutic  and chiral
programs.  Management expects that these efforts will result in the introduction
of other parties with interests and resources  which may be compatible with that
of the Company.  However,  no  assurances  can be given that the Company will be
successful in raising  additional  capital or entering into a business alliance.
Further,  there can be no assurance,  assuming the Company  successfully  raises
additional  funds or enters  into a business  alliance,  that the  Company  will
achieve  profitability or positive cash flow. If the Company is unable to obtain
adequate additional  financing or enter into such business alliance,  management
will be required to sharply curtail the Company's  immunotherapeutic program and
to curtail certain other of its operations.

Six-month period ended June 30, 1995 vs.
Six-month period ended June 30, 1994

     Revenues for the  six-month  period ended June 30, 1995 were  approximately
$671,000,  which was a decrease  of  approximately  $642,000,  or 49%,  over the
comparable period in 1994. Chiral  intermediate  revenues  decreased $752,000 to
$242,000  for the  six-month  period  ended  June 30,  1995 as  compared  to the
comparable 1994 period.  This decrease in chiral  intermediate  revenues was due
primarily to the sporadic  nature of orders from the  Company's  small  customer
base.  Chiral research  contract revenues for the first six months were $240,000
which was an  increase  of  $195,000  over the first  six  months of 1994.  This
increase in contract  revenues  was due to the Company  entering  into  research
contracts for new compounds and for expanding development of existing compounds.
Revenue backlog at June 30, 1995, for 1995 sales, for chiral  intermediates  and
research contracts decreased $73,000 or 11%, to $587,000 as compared to the June
30, 1994  backlog.  The Company is  negotiating  with new and old  customers for
additional chiral intermediate and research contract orders;  however,  there is
no assurance that these efforts will be successful. Investment income decreased,
$85,000,  or 31%,  to  $189,000 in the six months of 1995 as compared to the six
months of 1994 due to the decrease in funds available for investment.

     For the six  months  ended  June 30,  1995,  cost of goods  sold  decreased
$157,000, or 30%, to $364,000 (which includes certain fixed manufacturing costs)
as  compared  to the six  months  of  1994,  due to the  low  volume  of  chiral
intermediate  revenues.  Research  and  development  expenses  for the six month
period  ended June 30, 1995  increased  by $380,000,  or 13%, to  $3,346,000  as
compared  to the  same  period  in 1994,  primarily  due to an  increase  in the
Rockefeller   University   expense  and   clinical   trial   expenses   for  the
immunotherapeutic  program. Selling, general and administrative expenses for the
six-month period ended June 30, 1995 decreased  $380,000,  or 22%, to $1,364,000
as compared to the 1994 comparable

                                       10


<PAGE>


period,  primarily due to the absence in 1995 of any incentive bonus expense, as
no cash  bonuses are  projected  to be paid,  and lower  personnel  and facility
expenses.

     Net loss for the  six-month  period  ended June 30, 1995 was  approximately
$4,404,000  which was a decrease of approximately  $1,851,000,  or 30%, over the
comparable  period in 1994,  due  primarily to the  cessation  of the  Company's
biotreatment  operation at June 30, 1994. Loss from continuing operations during
the six-months period ended June 30, 1995 increased  $485,000,  or 12%, over the
comparable  quarter  in 1994,  primarily  due to  reduced  chiral  intermediates
revenues.

Three-month period ended June 30, 1995 vs.
Three-month period ended June 30, 1994

     Revenues for the three-month  period ended June 30, 1995 were approximately
$404,000,  which was a decrease  of  approximately  $347,000,  or 46%,  over the
comparable period in 1994. Chiral  intermediate  revenues  decreased $392,000 to
$224,000  for the  three-month  period  ended June 30,  1995 as  compared to the
comparable 1994 period.  This decrease in chiral  intermediate  revenues was due
primarily to the sporadic  nature of orders from the  Company's  small  customer
base.  Chiral  research  contract  revenues for the second  quarter of 1995 were
$100,000 which was an increase of $80,000 over the second quarter of 1994.  This
increase in contract  revenues  was due to the Company  entering  into  research
contracts for new compounds and for expanding development of existing compounds.
Investment  income  decreased,  $35,000,  or 30%, to $80,000 in the second three
months  of 1995 as  compared  to the  second  three  months  of 1994  due to the
decrease in funds available for investment.

     For the second  quarter ended June 30, 1995,  cost of goods sold  decreased
$101,000, or 33%, to $204,000 (which includes certain fixed manufacturing costs)
as  compared  to the  second  quarter  of 1994,  due to the low volume of chiral
intermediate  revenues.  Research and  development  expenses for the three-month
period  ended June 30, 1995  increased  by $164,000,  or 10%, to  $1,768,000  as
compared  to the  same  period  in 1994,  primarily  due to an  increase  in the
Rockefeller   University   expense  and   clinical   trial   expenses   for  the
immunotherapeutic  program. Selling, general and administrative expenses for the
three-month period ended June 30, 1995 decreased  $165,000,  or 19%, to $689,000
as compared to the 1994 comparable period,  primarily due to the absence in 1995
of any incentive bonus expense, as no cash bonuses are projected to be paid, and
lower personnel and facility expenses.

     Net loss for the three-month  period ended June 30, 1995 was  approximately
$2,257,000  which was a decrease of approximately  $1,323,000,  or 37%, over the
comparable  period in 1994,  due  primarily to the  cessation  of the  Company's
biotreatment  operation at June 30, 1994. Loss from continuing operations during
the three-months period ended June 30, 1995 increased $245,000, or 12%, over the
comparable  quarter  in 1994,  primarily  due to  reduced  chiral  intermediates
revenues.

                                       11

<PAGE>




PART II - OTHER INFORMATION

Item 1. -  None

Item 2. -  None

Item 3. -  None

Item 4. -  Submission of Matters to a Vote of Security Holders

     The Company held its Annual  Meeting of  Stockholders  on June 16, 1995. At
this meeting  stockholders of the Company were asked to vote for the election of
directors,  act upon the proposal to approve the  adoption of the  Corporation's
1995 Non-Employee  Directors' Incentive Plan, and for the proposal to ratify the
appointment  of  KPMG  Peat  Marwick  LLP as the  independent  certified  public
accountants of the Company for the year ending  December 31, 1995. All nominated
directors  were  elected,   the  proposal  to  adopt  the   Corporation's   1995
Non-Employee  Directors'  Incentive Plan was approved and the proposal regarding
the appointment of auditors was approved, by the following votes:

    A. Election of Directors:

<TABLE>
<CAPTION>

       Name                                         Number of Shares
       ----                              -------------------------------------
                                           For          Withheld     Abstained
                                           ---          --------     ---------
       <S>                                <C>              <C>            <C>
       Sol J. Barer                      6,865,556        92,262          --
       Frank T. Cary                     6,879,376        78,542          --
       Richard C. E. Morgan              6,882,946        74,972          --
       Walter L. Robb                    6,882,776        75,142          --
       Lee J. Schroeder                  6,879,726        78,192          --
       Richard G. Wright                 6,853,622       104,296          --

</TABLE>


    B. Adoption  of  the  Corporation's  1995  Non-Employee Directors' Incentive
       Plan:

<TABLE>
<CAPTION>

                                                   Number of Shares
                                         --------------------------------------
                                           For          Against       Abstained
                                           ---          -------       ---------
<S>                                       <C>            <C>           <C>
                                         6,225,048       601,704       69,915

</TABLE>


    C. Appointment of Auditors:

<TABLE>
<CAPTION>

                                                   Number of Shares
                                         --------------------------------------
                                           For          Against       Abstained
                                           ---          -------       ---------
<S>                                       <C>            <C>           <C>
                                         6,874,429        64,100       17,171

</TABLE>


Item 5. -  None

Item 6. -  Exhibits


<TABLE>

           <S>   <C>
            4.1  Form of 8% Convertible Debenture due July 31, 1997.

           10.1  Form of Registration Rights Agreement.

           10.2  Agent's Warrant.

           27    Financial  Data  Schedule  -  Article 5 for second quarter Form
                 10-Q.

</TABLE>


                                       12


<PAGE>




                                   SIGNATURES



     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.


                              CELGENE CORPORATION


DATE  August 14, 1995                   BY   /s/ Richard G. Wright
      ------------------------------         ------------------------------
                                             Richard G. Wright
                                             Chairman of the Board and
                                             Chief Executive Officer


DATE  August 14, 1995                  BY    /s/ Robert B. Eastty
      ------------------------------         ------------------------------
                                             Robert B. Eastty
                                             Controller
                                             (Chief Accounting Officer)


                                       13





     NEITHER THIS  DEBENTURE,  NOR THE SHARES  ISSUABLE UPON  CONVERSION OF THIS
DEBENTURE HAVE BEEN  REGISTERED  WITH THE UNITED STATES  SECURITIES AND EXCHANGE
COMMISSION OR THE  SECURITIES  COMMISSION OF ANY STATE  PURSUANT TO AN EXEMPTION
FROM  REGISTRATION  UNDER  REGULATION S PROMULGATED  UNDER THE SECURITIES ACT OF
1933, AS AMENDED (THE 'ACT').  THIS  DEBENTURE  SHALL NOT CONSTITUTE AN OFFER TO
SELL NOR A SOLICITATION OF AN OFFER TO BUY THE SECURITIES IN ANY JURISDICTION IN
WHICH  SUCH  OFFER  OR  SOLICITATION  WOULD  BE  UNLAWFUL.  THE  SECURITIES  ARE
'RESTRICTED' AND MAY NOT BE RESOLD OR TRANSFERRED  EXCEPT AS PERMITTED UNDER THE
ACT PURSUANT TO AN  EFFECTIVE  REGISTRATION  STATEMENT OR AN EXEMPTION  FROM THE
REGISTRATION REQUIREMENTS OF SUCH ACT

     NEITHER THIS  DEBENTURE,  NOR THE SHARES  ISSUABLE UPON  CONVERSION OF THIS
DEBENTURE  MAY BE OFFERED OR SOLD IN THE UNITED  STATES OR TO U.S.  PERSONS  (AS
SUCH TERM IS DEFINED  IN  REGULATION  S  PROMULGATED  UNDER THE ACT)  UNLESS THE
SECURITIES  ARE REGISTERED  UNDER THE ACT OR PURSUANT TO AN AVAILABLE  EXEMPTION
FROM THE REGISTRATION REQUIREMENTS OF THE ACT.

     THIS DEBENTURE  DOES NOT CONSTITUTE AN OFFER TO SELL, OR A SOLICITATION  OF
AN OFFER TO BUY,  ANY OF THE  SECURITIES  OFFERED  HEREBY  BY ANY  PERSON IN ANY
JURISDICTION IN WHICH IT IS UNLAWFUL FOR SUCH PERSON TO MAKE SUCH AN OFFERING OR
SOLICITATION. IN MAKING AN INVESTMENT DECISION, INVESTORS MUST RELY ON THEIR OWN
EXAMINATION  OF THE COMPANY AND THE TERMS OF THE OFFERING,  INCLUDING THE MERITS
AND THE  RISKS  INVOLVED.  THESE  SECURITIES  HAVE NOT BEEN  RECOMMENDED  BY ANY
FEDERAL OR STATE SECURITIES COMMISSION OR REGULATORY AUTHORITY. FURTHERMORE, THE
FOREGOING AUTHORITIES HAVE NOT CONFIRMED THE ACCURACY OR DETERMINED THE ADEQUACY
OF THIS DOCUMENT. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

No.                                                                 $       U.S.
   ----------                                                        -------

                              CELGENE CORPORATION

                   8% CONVERTIBLE DEBENTURE DUE JULY 31, 1997

     THIS DEBENTURE is one of a duly  authorized  issue of Debentures of CELGENE
CORPORATION,  a corporation  duly  organized and existing  under the laws of the
State of Delaware (the 'Company'),  designated as its 8% Convertible  Debentures
Due  July  31,  1997,  in an  aggregate  principal  amount  not  exceeding  U.S.
$12,000,000

     FOR  VALUE  RECEIVED,  the  Company  promises  to  pay to  __________,  the
registered    holder   hereof   (the    'Holder'),    the   principal   sum   of
___________________  ($_________  U.S.),  on or  prior  to July  31,  1997  (the
'Maturity Date') and to pay (continued on reverse)

IN WITNESS  WHEREOF,  the Company has caused this instrument to be duly executed
by an officer thereunto duly authorized.

                              CELGENE CORPORATION


Dated: July 1995              By:___________________________________
                                  Dr. Sol J. Barer,
                                  President and Chief
                                  Operating Officer



<PAGE>



(page 2 of  4 of Celgene Corporation Convertible Debenture due July 31, 1997)

interest on the  principal sum  outstanding  from time to time in arrears on the
Maturity  Date,  at the rate of 8% per annum  accruing  from the date of initial
issuance.  Accrual of interest shall commence on the first business day to occur
after the date hereof until  payment in full of the  principal sum has been made
or duly  provided for. The interest so payable will be paid on the Maturity Date
to the  person  in  whose  name  this  Debenture  (or  one or  more  predecessor
Debentures) is registered on the records of the Company  regarding  registration
and transfers of the Debentures (the 'Debenture Register') on the first business
day prior to the Maturity Date: provided, however, that the Company's obligation
to a transferee of this Debenture  arises only if such  transfer,  sale or other
disposition  is  made  in  accordance  with  the  terms  and  conditions  of the
Regulation  S  Subscription  Agreement  executed  by the  original  Holder  or a
subsequent  transferee.  All accrued and unpaid  interest shall bear interest at
the same rate of 8% per annum from the Maturity  Date until the date of payment.
The  principal  of, and interest on, this  Debenture are payable in such coin or
currency  of the  United  States of  America  as at the time of payment is legal
tender for  payment of public and  private  debts,  at the address of the Holder
last appearing on the Debenture Register of the Company as designated in writing
by the Holder from time to time.  The  Debenture  Register  shall  represent the
record  of  ownership  and  right to  receive  principal  and  interest  on this
Debenture. Interest and principal shall be payable only to the registered Holder
as  reflected  in the  Debenture  Register.  A transfer  of the right to receive
principal and interest under this Debenture shall be  transferable  only through
an  appropriate  entry  in  the  Debenture  Register  as  provided  herein.  The
forwarding of such payment shall constitute a payment of interest  hereunder and
shall  satisfy and  discharge  the  liability for principal and interest on this
Debenture to the extent of the sum represented by such payment.

     This Debenture is subject to the following additional provisions:

     1. The Debentures  are issuable in  denominations  of One Hundred  Thousand
Dollars  ($100,000  U.S.)  and  integral  multiples  of Fifty  Thousand  Dollars
($50,000 U.S.) in excess thereof.  The Debentures are  exchangeable for an equal
aggregate principal amount of Debentures of different authorized  denominations,
as requested by the Holders  surrendering  the same but shall not be issuable in
denominations  less than integral  multiples of Fifty Thousand  Dollars ($50,000
U.S.).  No service  charge  will be made for such  registration  of  transfer or
exchange.

     2. The Company shall be entitled to withhold from all payments of principal
of, and interest on, this  Debenture any amounts  required to be withheld  under
the  applicable  provisions  of the  United  States  income  tax  laws or  other
applicable  laws at the time of such  payments.  The Holder  shall pay any other
taxes, charges, or levies in connection with the issuance or transfer thereof.

     3. This Debenture has been issued subject to investment  representations of
the  original  purchaser  hereof and may be  transferred  or  exchanged  only in
compliance  with the Securities  Act of 1933, as amended (the 'Act'),  including
Regulation  S  promulgated  under  the Act.  Any  Holder of this  Debenture,  by
acceptance  hereof,  agrees to the  representations,  warranties  and  covenants
herein.  Prior to due presentment to the Company for transfer of this Debenture,
the Company and any agent of the Company may treat the person in whose name this
Debenture is duly  registered on the Company's  Debenture  Register as the owner
hereof for the purpose of receiving payment as herein provided and for all other
purposes,  whether or not this Debenture be overdue, and neither the Company nor
any such agent shall be affected by notice to the contrary.

     4. The Holder of this  Debenture  is entitled,  at its option,  at any time
commencing  on July 29, 1995 until  September  11, 1995 to convert the principal
amount of this Debenture, in whole but not in part, into shares of Common Stock,
par value $.01 per share (the  'Common  Stock') of the  Company at a  conversion
price (the 'Fixed  Conversion  Price')  for each share of Common  Stock equal to
100% of the Closing Bid Price, as defined, on July 28, 1995 and is entitled,  at
its option at any time  commencing  on  September  12,  1995 until July 30, 1997
(which is the last  business day prior to the  Maturity  Date hereof) to convert
the principal amount of this Debenture, in whole but not in part, into shares of
Common Stock of the Company at a conversion price ('Variable  Conversion Price')
for each share of Common  Stock  equal to the lesser of (a)  Eight-five  percent
(85%) of the Market Price (as defined) of the  Company's  Common  Stock,  or (b)
100% of the Closing Bid Price,  as defined,  on July 28,  1995.  For purposes of
this  Section 4, the  'Closing Bid Price' of the Common Stock for each day shall
be the closing bid price of the Common  Stock on such day as reported on the New
York Stock  Exchange  composite  tape,  or, if the Common Stock is not listed or
admitted for trading on such  Exchange,  on the  principal  national  securities
exchange on which is the Common Stock is listed or admitted  for trading,  or if
not listed or admitted  for trading on any  national  securities  exchange,  the
closing bid price of the Common Stock as reported by the National Association of
Securities Dealers Automated  Quotation System ('NASDAQ') National Market System
(or, if not so reported, the closing price) or, if not admitted for quotation on
the NASDAQ National Market System, the average of the high bid and the low asked
prices as recorded by the  National  Association  of  Securities  Dealers,  Inc.
through  NASDAQ,  or, if the Common Stock is not traded in the  over-the-counter
market,  the fair  market  value of one  share  of  Common  Stock on such day as
determined  in good faith by the Board of  Directors  (which  decision  shall be
conclusive).  For  purposes of this  Section 4,  'Market  Price'  shall mean the
average of the Closing Bid Price for the five  trading days prior to the Date of
Conversion  (as  herein  defined).  Such  conversion  shall  be  effectuated  by
surrendering  the  Debentures  to be  converted  by  overnight  courier  to  the
Company's  registrar and transfer  agent,  American  Stock  Transfer & Trust Co.
('Transfer  Agent'),  with the form of  conversion  notice  attached  hereto  as
Exhibit A (with an advance copy of the  Debenture and the  conversion  notice to
the Transfer Agent and the Company by facsimile), executed by the Holder of this
Debenture  evidencing  such Holder's  intention to convert this  Debenture,  and
accompanied,  in the event the Holder  desires to register  the shares of Common
Stock in a name other  than that of Holder,  by proper  assignment  hereof.  The
Company and the  Transfer  Agent shall make a  reasonable  effort to deliver the
converted  shares to the Holder within three  business days from date of receipt
of the conversion  notice and the original of this  Debenture.  In the event the
Holder  converts  the  Debenture  at the  Fixed  Conversion  Price  or  Variable
Conversion  Price, the accrued interest shall be payable to the Holder in shares
of Common Stock  (unless such  Debenture is redeemed for cash under the terms of
Section 5 herein),  and the interest and number of shares issued upon conversion
shall be  calculated  as  follows:

     Number of shares issued upon conversion = (Principal + Interest)/Conversion
         Price,  where 

           Principal  = The  principal amount of the  Debenture to be converted,

           Interest = Principal x (N/365) x .08, where N = the number of days 
           from July 28, 1995 to the date of conversion, and 

           Conversion Price = Either the Fixed Conversion Price or the Variable
           Conversion Price, as defined in this paragraph 4 herein, whichever is
           applicable at the time of such conversion.

                               (continued on attached)

<PAGE>

(page 3 of 4 of Celgene Corporation Convertible Debenture due July 31, 1997)

In all cases the conversion of this Debenture in full shall represent payment of
all  interest and  principal  payable to the Holder  hereunder.  No fractions of
shares or scrip  representing  fractions of shares will be issued on conversion,
but the  number of shares  issuable  shall be rounded  up to the  nearest  whole
share.  The  date  on  which  notice  of  conversion  is  given  (the  'Date  of
Conversion')  shall  be  deemed  to be the  date set  forth  in such  notice  of
conversion if the original of this  Debenture is received by the Transfer  Agent
within five business days  thereafter.  If the original of this Debenture is not
received  by the  Transfer  Agent  within five  business  days after the Date of
Conversion, the notice of conversion shall become null and void. In the event of
any stock split,  stock dividend payable in securities of the Company,  or other
reclassification  of the Common Stock,  the conversion  price shall be equitably
adjusted so that the Holder shall receive, in exchange for the conversion price,
such  securities or other property which it would have received had it converted
this  Debenture  immediately  prior  to such  stock  split,  dividend  or  other
reclassification. No service charge will be made for any such conversion.

     5. The Company  shall have the right to redeem this  Debenture  for cash by
giving notice (the 'Redemption Notice') to the Holder by facsimile,  original to
follow by two-day  courier,  within  one  business  day from the date  facsimile
notice of conversion is received by the Company.  The redemption  price shall be
paid to Holder within seven  calendar  days after such  facsimile has been given
except in the event the Common  Stock  price is below  $5.00,  in which case the
redemption  price  shall be paid to Holder  within 21  calendar  days after such
facsimile notice has been given.  The redemption price (the 'Redemption  Price')
shall be the greater of a) the amount  calculated by multiplying  the sum of the
Principal and accrued Interest of this Debenture,  as those terms are defined in
paragraph 4 above,  by a fraction,  the  numerator of which shall be the Closing
Bid Price on the proposed Date of Conversion, and the denominator of which shall
be the lesser of the  conversion  prices  described  in  clauses  (a) and (b) of
Section 4 above,  and b) 115% of the  Principal  and  accrued  Interest  of this
Debenture.  After receipt of the Redemption  Notice,  all rights with respect to
this Debenture,  including,  without limitation, the conversion rights contained
herein  (notwithstanding  the  furnishing  by the  holder  hereof of a notice of
conversion to the Company), shall forthwith terminate,  except only the right of
the holder to receive the Redemption Price.

     6. The Company is entitled,  at its option,  any time commencing on October
15, 1995 until July 30, 1996 to require the Holder to convert the  Principal and
accrued  Interest of this  Debenture,  as those terms are defined in paragraph 4
above, into shares of Common Stock of the Company at a conversion price for each
share of Common  Stock equal to the lesser of a) 75% of the Closing Bid Price on
the date the Company  provides  notice of conversion  and b) 100% of the Closing
Bid Price on July 28,  1995.  The Company is entitled,  at its option,  any time
commencing on July 31, 1996 until July 30, 1997 to require the Holder to convert
the Principal and accrued Interest of this Debenture, as those terms are defined
in paragraph 4 above, into shares of Common Stock of the Company at a conversion
price  for each  share of  Common  Stock  equal to the  lesser  of (a) or (b) of
Section 4 above.  In either  case,  the Company  shall  notify the Holder of the
Company's  intent to force  conversion  by giving  written  notice  ('Notice  of
Mandatory Conversion') to the Holder by facsimile, original to follow by two-day
courier,  before  midnight,  New York City time,  on the date of such  mandatory
conversion. The Company is not entitled to require conversion under this Section
6 if the  Company  makes  any  planned  press  release  either  a) on the day it
provides  such Notice of Mandatory  Conversion  to the Holder or b) prior to the
close of trading on the following business day.

     7. Except as expressly  provided  herein,  no  provision of this  Debenture
shall alter or impair the  obligation  of the  Company,  which is  absolute  and
unconditional,  to pay the principal of, and interest on, this  Debenture at the
time,  place,  and rate, and in the coin or currency,  herein  prescribed.  This
Debenture and all other  Debentures now or hereafter issued of similar terms are
direct  obligations  of the Company.  This  Debenture  ranks pari passu with all
other Debentures now or hereafter issued under the terms set forth herein.

     8. Except as provided by applicable  law, no recourse  shall be had for the
payment of the  principal  of, or the  interest on, this  Debenture,  or for any
claim based hereon,  or otherwise in respect hereof,  against any  incorporator,
shareholder,  officer or director,  as such, past,  present,  or future,  of the
Company or of any successor corporation,  whether by virtue of any constitution,
statute or rule of law, or by the  enforcement  of any  assessment or penalty or
otherwise, all such liability being, by the acceptance hereof and as part of the
consideration for the issue hereof, expressly waived and released.

     9. After this  Debenture  shall have been  surrendered  for  conversion  as
herein  provided  or notice of  conversion  shall have been given by the Company
pursuant  to Section 6 herein,  this  Debenture  shall no longer be deemed to be
outstanding  and all rights with respect to this Debenture,  including,  without
limitation,  the right to recei ve  interest  hereon and the  principal  hereof,
shall forthwith terminate as of the Date of Conversion, except only the right of
the holder hereof to receive shares of Common Stock in exchange herefor.

     10. This Debenture shall not entitle the holder hereof to any of the rights
of a stockholder  of the Company,  including  without  limitation,  the right to
vote, to receive dividends and other distributions, or to receive any notice of,
or to attend, meetings of stockholders or any other proceedings of the Company.

     11. If this Debenture shall be mutilated,  lost,  stolen or destroyed,  the
Company shall  execute and deliver,  in exchange and  substitution  for and upon
cancellation of a mutilated  Debenture,  or in lieu of or in substitution  for a
lost, stolen or destroyed Debenture, a new Debenture for the principal amount of
this Debenture so mutilated,  lost, stolen or destroyed but only upon receipt of
evidence  of such  loss,  theft or  destruction  of such  Debenture,  and of the
ownership thereof, and indemnity,  if requested,  all reasonably satisfactory to
the Company.

     12. Any Holder of this Debenture,  by acceptance  hereof,  agrees that such
Holder will not offer, sell or otherwise dispose of this Debenture or the shares
of Common Stock issuable upon exercise thereof except under  circumstances which
will not result in a violation of the Act,  including  Regulation S  promulgated
under the Act, or any applicable  state Blue Sky law or similar laws relating to
the sale of  securities  and the holder  agrees to provide the Company with such
documentation  as the Company shall deem necessary in accordance  with Section 4
of the  Regulation S  subscription  agreement  executed by the  original  holder
hereof to demonstrate that

                            (continued on attached)

<PAGE>
(page 4 of 4 of Celgene Corporation Convertible Debenture due July 31, 1997)

such offer, sale or disposition  complied with applicable  securities laws. This
provision shall similarly apply to subsequent transfers of this Debenture.

     13.This Debenture shall be governed by and construed in accordance with the
laws of the State of Delaware, without giving effect to conflicts of laws.

     14.For purposes hereof, the term 'business day' shall mean any day on which
banks  are  generally  open  for  business  in the  State of  Delaware,  USA and
excluding any Saturday and Sunday.

     15. In the event of a merger,  reorganization,  recapitalization or similar
event of or with  respect to the Company (a  'Corporate  Change')  (other than a
Corporate Change in which all or substantially all of the consideration received
by the holders of the Company's  equity  securities  upon such Corporate  Change
consists of cash or assets other than securities  issued by the acquiring entity
or any  affiliate  thereof),  this  Debenture  shall be assumed by the acquiring
entity and thereafter  this Debenture  shall be convertible  into such class and
type of securities  as the Holder would have  received had the Holder  converted
this Debenture immediately prior to such Corporate Change.

     16. Any notice or other  communication  required or  permitted  to be given
hereunder shall be given as provided  herein or delivered  against receipt if to
(i) the Company at, 7 Powder Horn Drive, Warren, New Jersey 07059,  Telecopy No.
(908) 805-3931 and (ii) the holder of this Debenture, to such holder at its last
address as shown on the  Debenture  Register  (or to such  other  address as the
party shall have furnished in writing in accordance  with the provisions of this
Section 16). Any notice or other communication mail shall be deemed given at the
time of receipt thereof.

     17.  Any  waiver by the  Company  or the  holder  hereof of a breach of any
provision of this Debenture  shall not operate as or be construed to be a waiver
of any other breach of such provision or of any breach of any other provision of
this  Debenture.  The failure of the Company or the holder hereof to insist upon
strict  adherence to any term of this Debenture on one or more  occasions  shall
not be  considered  a waiver or deprive  that party of the right  thereafter  to
insist upon strict  adherence to that term or any other term of this  Debenture.
Any waiver must be in writing.

     18.  If  any   provision  of  this   Debenture   is  invalid,   illegal  or
unenforceable,  the balance of this Debenture shall remain in effect, and if any
provision is inapplicable to any person or circumstance,  it shall  nevertheless
remain applicable to all other persons and circumstances.



<PAGE>

                                   EXHIBIT A

                              NOTICE OF CONVERSION

                    (To be Executed by the Registered Holder
                    in order to Convert the Debenture)Holder

The undersigned hereby irrevocably elects to convert the above Debenture No.
___________ into shares of Common Stock, par value $.01 per share (the 'Common
Stock'), of Celgene Corporation (the 'Company') according to the conditions
hereof, as of the date written below. If shares are to be issued in the name of
a person other than undersigned, the undersigned will pay all transfer taxes
payable with respect thereto and is delivering herewith such certificates and
opinions as reasonably requested by the Company. No fee will be charged to the
Holder for any conversion, except for transfer taxes, if any.

If this Debenture is being converted during the Restricted Period (as that term
is defined in the subscription agreement executed by the original purchaser of
this Debenture), the undersigned represents that it is not a U.S. Person as
defined in Regulation S promulgated under the United States Securities Act of
1933, as amended (the 'Act') and is not converting the Debenture on behalf of
any U.S. Person. The undersigned also represents and warrants that all offers
and sales by the undersigned of the shares of Common Stock issuable to the
undersigned upon conversion of the Debenture shall be made in compliance with
Regulation S, pursuant to registration of the Common Stock under the Act or
pursuant to an exemption from registration under the Act.


Conversion calculations:                        --------------------------------
                                                 Date of Conversion


                                                --------------------------------
                                                 Applicable Conversion Price


                                                --------------------------------
                                                 Signature


                                                --------------------------------
                                                 Name


                                                 Address
                                                --------------------------------
                                                --------------------------------

* The original Debenture and Notice of Conversion must be received by the
Company's Transfer Agent before any shares of Common Stock will be issued. If
the original of this Debenture is not received by the Transfer Agent (or such
other person as the Company may specify) within five business days after the
date of conversion specified above, this notice of conversion shall become null
and void.





                              Celgene Corporation

                         Registration Rights Agreement

         THIS REGISTRATION RIGHTS AGREEMENT (the 'Agreement') is entered into as
of July ___, 1995, by and among Celgene Corporation, a Delaware corporation (the
'Company'),  and the persons and  entities  listed on Exhibit A attached  hereto
(the 'Investors').

                                   Recitals:

WHEREAS,  pursuant to a Regulation S Subscription  Agreement (the  'Subscription
Agreement'),  by and among the Company and the Investors, the Company has agreed
to sell  and the  Investors  have  agreed  to  purchase  up to an  aggregate  of
$12,000,000 U.S.  principal  amount 8% Convertible  Debentures due July 31, 1997
(the  'Debentures')  of the Company  convertible  into  shares of the  Company's
Common Stock, par value $.01 per share (the 'Shares');

WHEREAS,  pursuant  to the terms  of,  and in  partial  consideration  for,  the
Investors' agreement to enter into the Subscription  Agreement,  the Company has
agreed to provide the Investors with certain registration rights with respect to
the Shares;

NOW  THEREFORE,  in  consideration  of  the  mutual  promises,  representations,
warranties, covenants and conditions set forth in the Subscription Agreement and
this  Registration  Rights  Agreement,  the Company and the  Investors  agree as
follows:

                                   Agreement:

         1.  Certain Definitions. As used in this Agreement, the following terms
             shall have the following respective meanings:

         'Commission'  shall mean the Securities and Exchange  Commission or any
other Federal agency at the time administering the Securities Act.

         'Common  Stock' shall mean the Company's  Common Stock,  par value $.01
per share.

         'Initiating  Holders'  shall  mean  holders  of  Debentures  having  an
aggregate principal amount of $3 million or more.

         'Other Registrable  Securities' shall mean those shares of Common Stock
heretofore or hereafter  issued pursuant to one or more agreements  granting the
purchasers  of such  securities  the  right to have the  Company  register  such
securities or include such securities in any other registration of the Company's
equity securities.

         'Registrable  Shares'  shall  mean (i) the  Shares,  (ii)  the  Warrant
Shares,  and (iii) any Common Stock of the Company issued or issuable in respect
of the Shares or the Warrant  Shares or upon any stock  split,  stock  dividend,
recapitalization  or similar  event;  provided,  however,  that shares of Common
Stock or other  securities  shall no longer be treated as Registrable  Shares if
(A) they  have been sold to or  through a broker or dealer or  underwriter  in a
public distribution or a public securities transaction,  (B) they have been sold
in  a  transaction   exempt  from  the  registration  and  prospectus   delivery
requirements  of the  Securities  Act so  that  all  transfer  restrictions  and
restrictive  legends with respect thereto are

<PAGE>


removed upon  consummation of such sale or (C) the Shares are available for sale
under Rule 144, in the  opinion of counsel to the  Company,  without  compliance
with the registration and prospectus delivery requirements of the Securities Act
so that all transfer  restrictions and restrictive  legends with respect thereto
may be removed upon the consummation of such sale.

         The terms 'register',  'registered' and 'registration' shall refer to a
registration  effected  by  preparing  and filing a  registration  statement  in
compliance  with  the  Securities  Act  and  applicable  rules  and  regulations
thereunder,  and  the  declaration  or  ordering  of the  effectiveness  of such
registration statement.

         'Registration  Expenses' shall mean all expense incurred by the Company
in  compliance  with  Section  2  hereof,  including,  without  limitation,  all
registration  and filing fees,  printing  expenses,  fees and  disbursements  of
counsel  for the  Company,  blue  sky  fees and  expenses,  reasonable  fees and
disbursements (not to exceed $10,000) of one counsel for all the selling holders
of Registrable Shares for a limited 'due diligence'  examination of the Company,
and the reasonable expenses of any special audits incident to or required by any
such  registration  (but excluding the compensation of regular  employees of the
Company, which shall be paid in any event by the Company).

         'Securities Act' shall mean the Securities Act of 1933, as amended,  or
any similar  federal  statute,  and the rules and  regulations of the Commission
thereunder, all as the same shall be in effect at the time.

         'Selling  Expenses' shall mean all  underwriting  discounts and selling
commissions  applicable  to the  sale of  Registrable  Shares  and all  fees and
disbursements  of one  counsel  for the selling  holders of  Registrable  Shares
(other than the fees  disbursements  of such  counsel  included in  Registration
Expenses).

         'Warrant  Shares'  shall mean the shares of Common  Stock  issuable  on
exercise of Warrant(s)  issued to Swartz  Investments,  Inc., in connection with
the issuance of the Debentures.

         2.  Requested Registration.

         The following  registration rights will apply only if at any time prior
the  expiration of these rights,  Regulation S promulgated  under the Securities
Act is rescinded or modified so as to preclude  non-United  States  persons from
reselling in United States public  securities  markets shares  received from the
Company,  or if, for any other reason, the Company refuses to issue unrestricted
Shares to an Investor  after the Restricted  Period,  as that term is defined in
the Debentures:

                  (a) Request for  Registration.  If the Company  shall  receive
from Initiating  Holders,  at any time after four (4) months following the final
closing of the sale of Debentures  pursuant to the  Subscription  Agreements,  a
written request that the Company effect a registration  with respect to all, but
not less than all, of the  Registrable  Shares held by such  Initiating  Holders
(which notice shall  specify the intended  method of  disposition),  the Company
shall:

                           (i)  promptly give written notice of the proposed 
registration to all other holders of Registrable Shares; and

                           (ii) as soon as  practicable  use its best efforts to
effect such registration  (including,  without  limitation,  the execution of an
undertaking to file post-


<PAGE>

effective  amendments,  appropriate  qualification  under applicable blue sky or
other  state   securities  laws  and  appropriate   compliance  with  applicable
regulations issued under the Securities Act) as may be so requested and as would
permit or facilitate  the sale and  distribution  of all or such portion of such
Registrable  Shares as are specified in such request,  together with all or such
portion of the Registrable Shares of any holder or holders of Registrable Shares
joining in such request as are  specified in a written  request  given within 15
days after  receipt of such written  notice from the Company;  provided that the
Company shall not be obligated to effect,  or to take any action to effect,  any
such registration pursuant to this Section 2:

                                    (A) after the Company has  effected one such
                           registration  pursuant to this Section 2 (a) and such
                           registration  has been declared or ordered  effective
                           by the  Commission  and the sale of such  Registrable
                           Shares shall have closed; or

                                    (B) within the period starting with the date
                           60 days prior to the Company's  good faith  estimated
                           date of filing of, and ending 180 days  following the
                           effective  date of, any  registered  offering  of the
                           Company's securities to the general public.

                            Subject to the foregoing  limitations in clauses (A)
and (B) above,  the Company  shall file a  registration  statement  covering the
Registrable  Shares so requested to be registered as soon as  practicable  after
receipt of the request or requests of the Initiating Holders,  but no later than
45 days following receipt of such request or requests;  provided,  however, that
if the Company shall furnish to such holders of Registrable Shares a certificate
signed by the President of the Company  stating that in the good faith  judgment
of the Board of Directors it would be seriously  detrimental  to the Company and
its stockholders for such registration  statement to be filed within such 45 day
period and it is therefore  advisable  to defer the filing of such  registration
statement, the Company shall have an additional period of up to 45 days (and not
to exceed the period  reasonably  determined  by the  Company to be  necessary),
after the  expiration  of such initial  45-day  period within which to file such
registration  of such initial 45-day period,  provided that during such time the
Company may not file a  registration  statement for  securities to be issued and
sold for its own account.

         The  registration  statement  filed  pursuant  to  the  request  of the
Initiating Holders may, subject to the provision of Section 2(b) below,  include
Other Registrable Securities,  other securities of the Company which are held by
officers  or  directors  of the  Company  or which are held by other  holders of
registration  rights,  and may include  securities of the Company being sold for
the account of the Company.

         (b)  Underwriting.  If the Initiating  Holders intend to distribute the
Registrable  Shares covered by their request by means of an  underwriting,  they
shall so advise the Company as a part of their  request made pursuant to Section
2 and the Company shall include such  information in the written notice referred
to in Section 2 (a) (i) above. The right of any holder of Registrable  Shares to
registration  pursuant  to  Section 2 shall be  conditioned  upon such  holder's
participation   in  such   underwriting  and  the  inclusion  of  such  holder's
Registrable Shares in such underwriting  (unless other wise mutually agreed by a
majority in interest of the  Initiating  Holders and such holder with respect to
such  participation  and inclusion) to the extent provided  herein.  A holder of
Registrable  Shares may elect to include in such  underwriting  all or a part of
the Registrable Shares it holds.

                  (i) If the Company shall request inclusion in any registration
pursuant  to  Section 2 of  securities  being  sold for its own  account,  or if
officers or directors of the


<PAGE>


Company holding other securities of the Company or other holders of registration
rights,  shall request inclusion in any registration  pursuant to Section 2, the
Initiating Holders shall, on behalf of all holders of Registrable Shares,  offer
to include Other Registrable  Securities and the securities of the Company, such
officers and  directors  and such other  holders of  registration  rights in the
underwriting  and may  condition  such offer on their  acceptance of the further
applicable  provisions of this  Agreement.  The Company shall (together with all
holders  of  Registrable  Shares,  officers  and  directors,  other  holders  of
registration  rights and holders of Other  Registrable  Securities  proposing to
distribute  their   securities   through  such   underwriting)   enter  into  an
underwriting  agreement in customary form with the underwriter or representative
of the  underwriters  selected  for  such  underwriting  by the  Company,  which
underwriter(s)  shall be reasonably  acceptable to a majority in interest of the
Initiating Holders.

                  (ii) Notwithstanding any other provision of this Section 2, if
the  representative  of the  underwriters  advises the  Company in writing  that
marketing   factors  require  a  limitation  on  the  number  of  shares  to  be
underwritten,  the Company shall so advise all holders of Registrable Shares and
other  shareholders  whose securities  would otherwise be underwritten  pursuant
hereto,  and the number of Registrable  Shares and other  securities that may be
included  in  the  registration  and  underwriting  shall  be  allocated  in the
following  manner:  the securities of the Company held by officers and directors
of the  Company  (other than  Registrable  Shares)  shall be excluded  from such
registration and underwriting to the extent required by such limitation, and, if
a limitation on the number of shares is still  required,  the Other  Registrable
Securities  shall be excluded pro rata with Registrable  Shares,  unless another
method of determining  such  exclusion is specified in the agreements  governing
the Other  Registrable  Securities,  according to the  relative  number of Other
Registrable  Securities  requested  to be  included  in  such  registration  and
underwriting,  from such registration and underwriting to the extent required by
such limitation, and, if a limitation on the number of shares is still required,
the number of Registrable  Shares that may be included in the  registration  and
underwriting  shall be  allocated  among all  holders of  Registrable  Shares in
proportion,  as nearly as practicable,  to the respective amounts of Registrable
Shares which they had requested to be included in such  registration at the time
of  filing  the  registration  statement.  No  Registrable  Shares  or any other
securities  excluded  from  the  underwriting  by  reason  of the  underwriter's
marketing limitation shall also be included in such registration.

                  (iii) If the  Company or any  officer,  director  or holder of
Registrable Shares or Other Registrable  Securities who has requested  inclusion
in such registration and underwriting as provided above disapproves of the terms
of the  underwriting,  such  person may elect to withdraw  therefrom  by written
notice  to  the  Company,  the  underwriter  and  the  Initiating  Holders.  The
securities so withdrawn shall also be withdrawn from registration.

         3. Expenses of  Registration.  The Company shall bear all  Registration
Expenses  incurred  in  connection  with  any  registration,   qualification  or
compliance of the Registrable  Shares  pursuant to this  Agreement.  All Selling
Expenses  shall be borne by the holder of the  securities so registered pro rata
on the basis of the number of their shares so registered.

                            4.   Registration   Procedures.   Pursuant  to  this
Agreement,  the Company will keep each holder of  Registrable  Shares advised in
writing as to the  initiation of a  registration  under this Agreement and as to
the completion thereof. At its expense, the Company will:
                  (a) Use reasonable efforts to keep such registration effective
for a period of 180 days or until the holder or holders  of  Registrable  Shares
have completed the distribution described in the registration statement relating
thereto, whichever first occurs;

<PAGE>


                  (b) Prepare and file with the Commission  such  amendments and
supplements to such registration statement and the prospectus used in connection
with  such  registration  statement  as may be  necessary  to  comply  with  the
provisions of the Securities  Act with respect to the  disposition of securities
covered by such registration statement; and

                  (c) Furnish such number of  prospectuses  and other  documents
incidental thereto,  including any amendment of or supplement to the prospectus,
as a holder of Registrable Securities from time to time may reasonably request.

         5.  Indemnification.

                  (a) The Company  will  indemnify  each  holder of  Registrable
Shares,  each  of  its  officers,   directors  and  partners,  and  each  person
controlling   such  holder  of  Registrable   Shares,   with  respect  to  which
registration has been effected pursuant to this Agreement, and each underwriter,
if any and each  person  who  controls  any  underwriter,  and their  respective
counsel  against  all  claims,  losses,  damages and  liabilities  (or  actions,
proceedings or settlements  in respect  thereof)  arising out of or based on any
untrue  statement (or alleged untrue  statement) of a material fact contained in
any prospectus, or other document incident to any such registration, or based on
any omission (or alleged  omission) to state therein a material fact required to
be stated therein or necessary to make the statements therein not misleading, or
any  violation by the Company of the  Securities  Act or any rule or  regulation
thereunder  applicable to the Company in connection  with any such  registration
and will reimburse each such holder of Registrable Shares, each of its officers,
directors and partners,  and each person  controlling such holder of Registrable
Shares, each such underwriter and each person who controls any such underwriter,
for any  legal  and any  other  expenses  as they  are  reasonably  incurred  in
connection  with  investigating  and  defending  any such claim,  loss,  damage,
liability or action,  provided,  however,  that the indemnity  contained in this
Section  5(a) shall not apply to amounts paid in  settlement  of any such claim,
loss,  damage,  liability or action if such  Settlement is effected  without the
consent of the  Company;  and  provided  further  that the Company  shall not be
liable  in any  such  case to the  extent  that any such  claim,  loss,  damage,
liability  or  expense  arises  out of or is based on any  untrue  statement  or
omission based upon written information  furnished to the Company by such holder
of  Registrable  Shares or  underwriter  and stated to be  specifically  for use
therein.  The foregoing  indemnity agreement is further subject to the condition
that insofar as it relates to any untrue  statement,  alleged untrue  statement,
omission or alleged  omission made in a preliminary  prospectus,  such indemnity
agreement shall not inure to the benefit of the foregoing indemnified parties if
copies  of  a  final  prospectus   correcting  the   misstatement,   or  alleged
misstatement,  omission  or alleged  omission  upon which such loss,  liability,
claim or damage is based is timely  delivered  to such  indemnified  party and a
copy thereof was not  furnished  to the person  asserting  the loss,  liability,
claim or damage.

         (b) Each holder of Registrable  Shares will, if Registrable Shares held
by it are  included in the  securities  as to which such  registration  is being
effected,  indemnify  the Company,  each of its  directors and officers and each
underwriter,  if any, of the Company's securities covered by such a registration
statement,  each person who controls the Company or such underwriter  within the
meaning of the Securities  Act and the rules and  regulations  thereunder,  each
other such holder of Registrable Shares and each of its officers,  directors and
partners,  and each person  controlling such holder of Registrable  Shares,  and
their respective counsel against all claims, losses, damages and liabilities (or
actions,  proceedings or settlements in respect thereof) arising out of or based
on any untrue  statement  (or  alleged  untrue  statement)  of a  material  fact
relating  to  such  Holder  contained  in  any  such   registration   statement,
prospectus,  offering  circular or other  document,  or any omission (or alleged
omission)  to state  therein a  material  fact  required  to be  stated  therein
relating to such holder or necessary


<PAGE>

to make the  statements  therein  relating to such holder not  misleading or any
violation  by such  holder  of any  rule or  regulation  promulgated  under  the
Securities  Act  applicable  to such  holder and  relating to action or inaction
required  of such  holder in  connection  with any such  registration;  and will
reimburse the Company, such holders of Registrable Shares, directors,  officers,
partners,  persons,  underwriters  or control persons for any legal or any other
expense  reasonably  incurred in connection with  investigating or defending any
such claim, loss, damage,  liability or action , in each case to the extent, but
only to the extent,  that such untrue statement (or alleged untrue statement) or
omission  (or  alleged  omission)  relating  to  such  holder  is  made  in such
registration  statement,  prospectus,  offering  circular  or other  document in
reliance  upon and in  conformity  with  written  information  furnished  to the
Company by such holder of Registrable  Shares and stated to be specifically  for
use  therein;  provided,  however,  that  the  obligations  of such  holders  of
Registrable Shares hereunder shall be limited to an amount equal to the proceeds
to each such  holder  of  Registrable  Shares  of  securities  sold  under  such
registration  statement,  prospectus,  offering  circular  or other  document as
contemplated herein and provided further that such  indemnification  obligations
shall not apply if the Company  modifies or changes to a material extent written
information furnished by such Holder.

         (c) Each party  entitled to  indemnification  under this Section 5 (the
'Indemnified  Party')  shall  give  notice  to the  party  required  to  provide
indemnification (the 'Indemnifying Party') promptly after such Indemnified Party
has actual knowledge of any claim as to which indemnity may be sought, and shall
permit the  Indemnifying  Party to assume  the  defense of any such claim or any
litigation  resulting  therefrom,  provided  that  counsel for the  Indemnifying
Party,  who shall conduct the defense of such claim or any litigation  resulting
therefrom, shall be approved by the Indemnified Party, (whose approval shall not
unreasonably be withheld or delayed),  and the Indemnified Party may participate
in such defense at such indemnified  party's expense,  and provided further that
the failure of any Indemnified Party to give notice as provided herein shall not
relieve the  Indemnifying  Party of its  obligations  under this  Agreement.  No
Indemnifying Party, in the defense of any such claim or litigation, shall except
with the consent of each Indemnified Party,  consent to entry of any judgment or
enter into any  settlement  which  does not  include  as an  unconditional  term
thereof the giving by the claimant or plaintiff to such  Indemnified  Party of a
release  from  all  liability  in  respect  to such  claim or  litigation.  Each
Indemnified  Party shall furnish such information  regarding itself or the claim
in question as an  Indemnifying  Party may reasonably  request in writing and as
shall be  reasonably  required  in  connection  with  defense  of such claim and
litigation resulting therefrom.

         6.  Information  by  Holder  of  Registrable  Shares.  Each  holder  of
Registrable Shares shall furnish to the Company such information  regarding such
holder of  Registrable  Shares and the  distribution  proposed by such holder of
Registrable Shares as the Company may reasonably request in writing and as shall
be reasonably  required in connection with any registration  referred to in this
Agreement.

         7. No transfer or Assignment of  Registration  Rights.  Each Investor's
rights under this  Agreement  to cause the Company to register  the  Registrable
Shares may be transferred  or assigned by an Investor  (other than to affiliates
of such Investors) only to a purchaser of a Debenture in the principal amount of
at least $1,000,000 or at least 125,000 shares and such assignment shall only be
effective  upon  delivery of written  notice of such  assignment  to the Company
within thirty (30) days of the assignment.


<PAGE>



         8.  Miscellaneous.

            8.1  Governing  Law.   This  agreement  shall  be  governed  by  and
construed in accordance  with the laws of the State of Delaware  without  giving
effect to conflict of laws.
            8.2 Successors and Assigns. Except as otherwise provided herein, the
provisions  hereof  shall  inure to the  benefit  of, and be binding  upon,  the
successors, assigns, heirs, executors and administrators of the parties hereto.

            8.3 Entire Agreement. This Agreement constitutes the full and entire
understanding  and  agreement  between  the  parties  with regard to the subject
matter hereof.
            8.4 Notices,  etc. All notices and other communications  required or
permitted hereunder shall be in writing and shall be mailed by first-class mail,
postage  prepaid,  or  delivered  by hand or by  messenger  or courier  delivery
service,  addressed (a) if to an Investor,  at such Investor's address set forth
on  Exhibit A hereof,  or at such  other  address  as such  Investor  shall have
furnished to the Company in writing,  or (b) if to the  Company,  at the address
set forth on the  signature  page hereof or at such other address as the Company
shall have furnished to each Investor and each such other holder in writing.

            8.5 Delays or Omissions. No delay or omission to exercise any right,
power or remedy  accruing  to any  holder of any  Registrable  Shares,  upon any
breach or default of the Company  under this  Agreement,  shall  impair any such
right,  power or remedy of such holder nor shall it be  construed to be a waiver
of any such  breach or  default,  or an  acquiescence  therein,  or of or in any
similar  breach or  default  thereunder  occurring;  nor shall any waiver of any
single  breach or  default  be deemed a waiver  of any other  breach or  default
thereafter  occurring.  Any waiver,  permit,  consent or approval of any kind or
character  on the  part of any  holder  of any  breach  or  default  under  this
Agreement,  or any  waiver  on  the  part  of any  party  of any  provisions  or
conditions of this Agreement,  must be in writing and shall be effective only to
the extent  specifically set forth in such writing.  All remedies,  either under
this  Agreement,  or by law  or  otherwise  afforded  to any  holder,  shall  be
cumulative and not alternative.

            8.6  Counterparts.  This  agreement may be executed in any number of
counterparts,  each of which may be executed by less than all of the  Investors,
each of which shall be enforceable  against the parties actually  executing such
counterparts, and all of which together shall constitute one instrument.

            8.7. Severability. In the case any provision of this agreement shall
be invalid, illegal or unenforceable,  the validity, legality and enforceability
of the  remaining  provisions  shall  not in any  way be  affected  or  impaired
thereby.
            8.8  Amendments.  The provisions of this Agreement may be amended at
any time and from time to time, and particular  provisions of this Agreement may
be waived,  with and only with an agreement or consent in writing  signed by the
Company and by the Investors  currently holding 50% of the Registrable Shares as
of the date of such amendment or waiver.

            8.9  Termination  of  Registration   Rights.  This  Agreement  shall
terminate  at the earlier of July 28, 1997 and at such time as there cease to be
any outstanding shares which constitutes Registrable Shares as defined herein.

The foregoing  Registration  Rights  Agreement is hereby executed as of the date
first above written.

<PAGE>


Celgene Corporation                                           Investors


By:  ___________________________            _________________________________

Title:  __________________________          By:  ____________________________

Address: 7 Powder Horn Drive                Name:  __________________________
              Warren, NJ 07059
              Attn: Mr. Richard G. Wright   Title: ___________________________
              Fax: (908)805-3931






THE SECURITIES  REPRESENTED BY THIS  CERTIFICATE  HAVE NOT BEEN REGISTERED UNDER
THE  SECURITIES  ACT OF 1933,  AS  AMENDED,  AND MAY NOT BE  SOLD,  TRANSFERRED,
PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF REGISTRATION OR
THE AVAILABILITY OF AN EXEMPTION FROM REGISTRATION UNDER SAID ACT.

Warrant to Purchase
105,000 shares


                        Warrant to Purchase Common Stock
                                       of
                              CELGENE CORPORATION

         THIS  CERTIFIES  that  Swartz  Investments,   Inc.  ('Holder')  or  any
subsequent holder hereof, has the right to purchase from Celgene Corporation,  a
Delaware  corporation  (the  'Company'),  not more than  105,000  fully paid and
nonassessable  shares of the Company's  Common  Stock,  par value $.01 per share
('Common  Stock'),  at a price of $9.60  per  share  subject  to  adjustment  as
provided  in Section 4 below (the  'Exercise  Price'),  at any time on or before
5:00 p.m., Atlanta, Georgia time, on July 31, 2000.

         The holder of this Warrant agrees with the Company that this Warrant is
issued and all rights  hereunder shall be held subject to all of the conditions,
limitations and provisions set forth herein.

         1.       Exercise.

         This Warrant may be  exercised  as to all or any lesser  number of full
shares of Common Stock covered hereby upon  surrender of this Warrant,  with the
Subscription Form attached hereto duly executed, together with the full Exercise
Price (as  hereinafter  defined) in cash, or by certified or official bank check
payable in New York  Clearing  House Funds for each share of Common  Stock as to
which this Warrant is  exercised,  at the office of the  Company,  7 Powder Horn
Drive,  Warren, N.J. 07059, or at such other office or agency as the Company may
designate  in  writing,   by  overnight  mail,  with  an  advance  copy  of  the
Subscription  Form by facsimile (such surrender and payment  hereinafter  called
the 'exercise of this Warrant').  The 'Date of Exercise' of the Warrant shall be
defined  as the  date set  forth  in the  Subscription  Form  provided  that the
original Warrant and  Subscription  Form are received by the Company within five
business days thereafter.  The original  Warrant and  Subscription  Form must be
received  within five days of the Date of  Exercise,  or the  Subscription  Form
shall be considered void. This Warrant shall be canceled upon its exercise, and,
as soon as practical thereafter,  the holder hereof shall be entitled to receive
a certificate or certificates for the number of shares of Common Stock purchased
upon such exercise and a new Warrant or Warrants  (containing terms identical to
this Warrant)  representing any unexercised portion of this Warrant. Each person
in whose name any  certificate  for shares of Common Stock is issued shall,  for
all

<PAGE>


purposes,  be deemed to have  become the holder of record of such  shares on the
Date of Exercise of this Warrant,  irrespective  of the date of delivery of such
certificate. The person in whose name this Warrant is registered shall be deemed
the owner therof and of the Warrant  evidenced hereby for all purposes.  Nothing
in this  Warrant  shall be construed as  conferring  upon the holder  hereof any
rights as a shareholder of the Company.

         2.       Payment of Warrant Price.

         Payment of the Exercise Price may be made by any of the following, or a
combination thereof, at the election of Holder:

         (i)      cash, check or wire transfer; or

         (ii)  surrender of this Warrant at the principal  office of the Company
together with notice of election,  in which event the Company shall issue Holder
a number of shares of Common Stock computed using the following formula:

                           X = Y (A-B)/A

where:   X = the number of shares of Common Stock to be issued to Holder.

         Y = the number of shares of Common Stock for which this Warrant
             is exercisable.

                  A = the  Market  Price  of one  share  of  Common  Stock  (for
                  purposes of this Section  2(ii),  the 'Market  Price' shall be
                  defined as the closing  bid price of the Common  Stock for the
                  five  trading  days  prior  to the  Date of  Exercise  of this
                  Warrant, as reported by the National Association of Securities
                  Dealers  Automated  Quotation  System  ('NASDAQ'),  or if  the
                  Common Stock is not traded on NASDAQ, the closing bid price in
                  the over-the-counter  market;  provided,  however, that if the
                  Common Stock is listed on a stock  exchange,  the Market Price
                  shall be the closing price on such exchange).

                  B = the Exercise Price.

         3.       Transfer and Registration.

         Subject to the  provisions of Section 7 of this  Warrant,  this Warrant
may be transferred on the books of the Company,  wholly or in part, in person or
by attorney,  upon surrender of this Warrant properly  endorsed,  with signature
guaranteed.  This Warrant shall be canceled upon such  surrender and, as soon as
practicable  thereafter,  the  person to whom  such  transfer  is made  shall be
entitled to receive a new Warrant or Warrants as to the portion of this  Warrant
transferred,  and the holder of this Warrant  shall be entitled to receive a new
Warrant or Warrants as to the portion hereof retained.

<PAGE>


         4.       Anti-Dilution Adjustments.

         (a) If the  Company  shall at any time  declare a  dividend  payable in
shares of Common Stock,  then the holder  hereof,  upon exercise of this Warrant
after the record date for the  determination of holders of Common Stock entitled
to receive such  dividend,  shall be entitled to receive  upon  exercise of this
Warrant,  in addition  to the number of shares of Common  Stock as to which this
Warrant is  exercised,  such  additional  shares of Common  Stock as such holder
would have received had this Warrant been  exercised  immediately  prior to such
record date.

         (b) If the  Company  shall at any time  effect  a  recapitalization  or
reclassification  of such  character  that the shares of Common  Stock  shall be
changed into or become  exchangeable  for a larger or smaller  number of shares,
then upon the effective date thereof, the number of shares of Common Stock which
the holder  hereof shall be entitled to purchase  upon  exercise of this Warrant
shall be increased or decreased, as the case may be, in direct proportion to the
increase or  decrease in the number of shares of Common  Stock by reason of such
recapitalization  or  reclassification,  and the Exercise Price shall be, in the
case of an increase in the number of shares,  proportionately  decreased and, in
the case of a decrease in the number of shares, proportionally increased.

         (c) If the Company  shall at any time  distribute  to holders of Common
Stock cash,  evidences of indebtedness or other securities or assets (other than
cash dividends or distributions payable out of earned surplus) then, in any such
case, the holder of this Warrant shall be entitled to receive,  upon exercise of
this  Warrant,  with  respect to each share of Common Stock  issuable  upon such
exercise, the amount of cash or evidences of indebtedness or other securities or
assets  which such holder  would have been  entitled to receive  with respect to
each such share of Common  Stock as a result of the  happening of such event had
this Warrant been exercised  immediately  prior to the record date or other date
fixing shareholders to be affected by such event.

         (d) If the  Company  shall at any time  consolidate  or merge  with any
other corporation or transfer all or substantially  all of its assets,  then the
Company shall deliver written notice to the Holder of such merger, consolidation
or sale of assets at least thirty (30) days prior to the closing of such merger,
consolidation  or sale of assets and this  Warrant  shall  terminate  and expire
immediately  prior  to the  closing  of such  merger,  consolidation  or sale of
assets.

         (e) As used in this Warrant,  the term 'Exercise  Price' shall mean the
purchase  price per share  specified in this Warrant until the  occurrence of an
event stated in subsection (b) of this Section 4 and thereafter  shall mean said
price as adjusted  from time to time in accordance  with the  provisions of said
subsection. No such adjustment shall be made unless such adjustment would change
the  Exercise  Price at the time by $.01 or more;  provided,  however,  that all
adjustments  not so made shall be deferred and made when the  aggregate  thereof
would change the Exercise Price at the time by $.01 or more. No adjustment  made
pursuant to any  provision of this Section 3 shall have the effect of

<PAGE>


increasing  the total  consideration  payable  upon  exercise of this Warrant in
respect of all the Common Stock as to which this Warrant may be exercised.

         (f) In the event that at any time,  as a result of an  adjustment  made
pursuant to this Section 4, the holder of this Warrant  shall,  upon exercise of
this  Warrant,  become  entitled to receive  shares  and/or other  securities or
assets  (other than Common Stock) then,  wherever  appropriate,  all  references
herein to shares of Common  Stock shall be deemed to refer to and  include  such
shares and/or other  securities  or assets;  and  thereafter  the number of such
shares and/or other  securities  or assets shall be subject to  adjustment  from
time to time in a manner and upon terms as nearly  equivalent as  practicable to
the provisions of this Section 4.

         5.       Fractional Interests.

                  No fractional shares or scrip  representing  fractional shares
shall be issuable  upon the  exercise of this  Warrant,  but on exercise of this
Warrant,  the holder hereof may purchase only a whole number of shares of Common
Stock.  The  Company  shall make a payment in cash in respect of any  fractional
shares  which  might  otherwise  be  issuable  upon  exercise  of this  Warrant,
calculated by multiplying the fractional share amount by the Market Price of the
Company's Common Stock on the Date of Exercise.

         6.       Reservation of Shares.

                  The  Company  shall at all times  reserve  for  issuance  such
number of authorized  and unissued  shares of Common Stock (or other  securities
substituted  therefor  as herein  above  provided)  as shall be  sufficient  for
exercise of this Warrant. The Company covenants and agrees that upon exercise of
this Warrant,  all shares of Common Stock  issuable upon such exercise  shall be
duly and validly issued, fully paid, nonassessable and not subject to preemptive
rights of any shareholders..

         7.       Restrictions on Transfer.

                  This Warrant and the Common Stock issuable on exercise  hereof
have not been registered  under the Securities Act of 1933, as amended,  and may
not be sold, transferred,  pledged, hypothecated or otherwise disposed of in the
absence of  registration or the  availability of an exemption from  registration
under said Act and the Holder has furnished to the Company an opinion of counsel
reasonably  satisfactory to the Company to such effect, and any shares of Common
Stock issued upon exercise of this Warrant shall bear an  appropriate  legend to
that effect.  This Warrant may not be exercised,  and any shares of Common Stock
issuable  on exercise  hereof may not be  transferred  unless  such  exercise or
transfer would not result in a violation of the provisions of the Securities Act
of 1933, as amended.




<PAGE>


         8.       Benefits of this Warrant.

                  Nothing in this Warrant  shall be construed to confer upon any
person  other  than the  Company  and the  holder of this  Warrant  any legal or
equitable  right,  remedy or claim under this Warrant and this Warrant  shall be
for the sole  and  exclusive  benefit  of the  Company  and the  holder  of this
Warrant.

         9.       Applicable Law.

                  This  Warrant is issued  under and shall for all  purposes  be
governed by and construed in accordance  with the laws of the State of Delaware,
without giving effect to conflicts of law.

         10.      Loss of Warrant.

                  Upon  receipt by the Company of  evidence of the loss,  theft,
destruction  or mutilation of this Warrant,  and (in the case of loss,  theft or
destruction)  of indemnity or security  reasonably  satisfactory to the Company,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall execute and deliver a new Warrant of like tenor and date.

         11.      Notice to Company.

                  Notices or  demands  pursuant  to this  Warrant to be given or
made by the holder of this  Warrant to or on the Company  shall be  sufficiently
given or made if sent by certified or registered mail, return receipt requested,
postage prepaid or by overnight delivery (with personal delivery  acknowledged),
and addressed,  until another address is designated in writing by the Company to
Celgene Corporation, 7 Powder Horn Drive, Warren, NJ 07059 ; Attention: Chairman
of the Board and Chief Executive Officer.





<PAGE>




         IN WITNESS WHEREOF, this Warrant is hereby executed effective as of the
date set forth below.


Dated as of:  August ___, 1995

                                                             CELGENE CORPORATION



                                           By:  ______________________________

                                           Print Name:  ________________________

                                           Its: _______________________________






<PAGE>


                               SUBSCRIPTION FORM

TO:  CELGENE CORPORATION

         The  undersigned  hereby  irrevocably  exercises  the right to purchase
____________  shares of Common  Stock of CELGENE  CORPORATION  evidenced  by the
attached Warrant,  and herewith makes payment of the Exercise Price with respect
to such shares in full, all in accordance  with the conditions and provisions of
said Warrant.

         The  undersigned  agrees  not to offer,  sell,  transfer  or  otherwise
dispose of any of such Common Stock, except in accordance with the provisions of
Section 7 of the Warrant,  and consents that the following legend may be affixed
to the certificates  for the Common Stock hereby  subscribed for, if such legend
is applicable:

         'The  securities   represented  by  this   certificate  have  not  been
         registered under the Securities Act of 1933, as amended, and may not be
         sold,  transferred,  pledged,  hypothecated or otherwise disposed of in
         the absence of  registration  or the  availability of an exemption from
         registration under said Act.'

         The undersigned  requests that  certificates for such shares be issued,
and a warrant  representing any unexercised portion thereof be issued,  pursuant
to the Warrant in the name of and delivered to:



--------------------------------------------------------------------------------
                                      Name


--------------------------------------------------------------------------------
                                    Address


Dated:

--------------------------------------------------------------------------------
                         Signature of Registered Holder


--------------------------------------------------------------------------------
                       Name of Registered Holder (Print)


--------------------------------------------------------------------------------
                                    Address
--------------------------------------------------------------------------------
The attached  Warrant and the securities  issuable on exercise  thereof have not
been  registered  under  the  Securities Act of 1933, as amended, and may not be
sold, transferred, pledged, hypothecated or otherwise disposed of in the absence
of registration or the availability of an exemption from registration under said
Act.
--------------------------------------------------------------------------------


                                   ASSIGNMENT

                    (To be executed by the registered holder
                       desiring to transfer the Warrant)

FOR VALUE RECEIVED, the undersigned holder of the attached Warrant hereby sells,
assigns  and  transfers  unto the  person or  persons  below  named the right to
purchase ___________ shares of the Common Stock of CELGENE CORPORATION evidenced
by the  attached  Warrant and does  hereby  irrevocably  constitute  and appoint
_______________________  attorney to transfer  the said  Warrant on the books of
the Company, with full power of substitution in the premises.

Dated:                                            ______________________________
                                                  Signature

Fill in for new Registration of Warrant:

-----------------------------------------
                  Name


-----------------------------------------
                  Address


-----------------------------------------
Please print name and address of assignee
(including zip code number)


--------------------------------------------------------------------------------

NOTICE

The signature to the foregoing  Subscription  Form or Assignment must correspond
to the  name  as  written  upon  the  face  of the  attached  Warrant  in  every
particular, without alteration or enlargement or any change whatsoever.
--------------------------------------------------------------------------------



<TABLE> <S> <C>


<ARTICLE>                     5
       
<S>                           <C>
<PERIOD-TYPE>                        6-MOS
<FISCAL-YEAR-END>              DEC-31-1995
<PERIOD-END>                   JUN-30-1995
<CASH>                             896,874
<SECURITIES>                     4,012,155 
<RECEIVABLES>                      321,313 
<ALLOWANCES>                             0 
<INVENTORY>                              0 
<CURRENT-ASSETS>                 5,710,509 
<PP&E>                           8,430,712 
<DEPRECIATION>                   6,854,806 
<TOTAL-ASSETS>                   7,327,665 
<CURRENT-LIABILITIES>            1,610,136 
<BONDS>                                  0 
<COMMON>                            78,627 
                    0 
                              0 
<OTHER-SE>                       5,638,902 
<TOTAL-LIABILITY-AND-EQUITY>     7,327,665 
<SALES>                            242,138 
<TOTAL-REVENUES>                   670,878 
<CGS>                              363,926 
<TOTAL-COSTS>                      363,926 
<OTHER-EXPENSES>                 4,710,548 
<LOSS-PROVISION>                         0 
<INTEREST-EXPENSE>                       0 
<INCOME-PRETAX>                          0 
<INCOME-TAX>                             0 
<INCOME-CONTINUING>             (4,403,596)
<DISCONTINUED>                           0 
<EXTRAORDINARY>                          0 
<CHANGES>                                0 
<NET-INCOME>                    (4,403,596)
<EPS-PRIMARY>                         (.56)
<EPS-DILUTED>                            0 

        

</TABLE>


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