CELGENE CORP /DE/
DEF 14A, 1995-04-28
INDUSTRIAL ORGANIC CHEMICALS
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<PAGE>
                           SCHEDULE 14A INFORMATION 

             Proxy Statement Pursuant to Section 14(a) of the Securities
                       Exchange Act of 1934 (Amendment No.    )

          Filed by the Registrant [x]
          Filed by a Party other than the Registrant [ ]


          Check the appropriate box:

          [ ]  Preliminary Proxy Statement
          [ ]  Confidential, for Use of the Commission Only (as permitted by
               Rule 14a-6(e)(2))
          [x]  Definitive Proxy Statement
          [ ]  Definitive Additional Materials
          [ ]  Soliciting Material Pursuant to Section 240.14a-11(c) or
               Section 240.14a-12

                                CELGENE CORPORATION
          .................................................................
                   (Name of Registrant as Specified In Its Charter)

          .................................................................
       (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


          Payment of Filing Fee (Check the appropriate box):

          [x]  $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1),
               14a-6(i)(2) or Item 22(a)(2) of Schedule 14A.
          [ ]  $500 per each party to the controversy pursuant to Exchange
               Act Rule 14a-6(i)(3).
          [ ]  Fee computed on table below per Exchange Act Rules 
               14a-6(i)(4) and 0-11.

               1)  Title of each class of securities to which transaction
          applies:
                    
          .................................................................

               2)  Aggregate number of securities to which transaction
          applies:
                    
          .................................................................

               3)  Per unit price or other underlying value of transaction
          computed   pursuant to Exchange Act Rule 0-11 (Set forth the
          amount on which the filing fee is calculated and state how it was
          determined):
                     
          .................................................................

               4)  Proposed maximum aggregate value of transaction:
                    
          .................................................................

               5)  Total fee paid:
                  
          .................................................................

          [ ]  Fee paid previously with preliminary materials.
          [ ]  Check box if any part of the fee is offset as provided by
               Exchange Act Rule 0-11(a)(2) and identify the filing for
               which the offsetting fee was paid previously.  Identify the
               previous filing by registration statement number, or the
               Form or Schedule and the date of its filing.

               1)   Amount Previously Paid:
                     
          .................................................................

               2)   Form, Schedule or Registration Statement No.:

          .................................................................

               3)   Filing Party:

          .................................................................

               4)   Date Filed:

          .................................................................


<PAGE>
                              CELGENE CORPORATION
                              7 POWDER HORN DRIVE
                            WARREN, NEW JERSEY 07059
 
                            ------------------------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
 
                            ------------------------
     The   annual   meeting  of   stockholders   of  CELGENE   CORPORATION  (the
'Corporation') will be  held at  the Somerset  Hills Hotel,  200 Liberty  Corner
Road, Warren, New Jersey on Friday, June 16, 1995, at 1:00 p.m., local time, for
the following purposes:
 
          1. to elect six directors;
 
          2.  to consider and act upon a proposal to approve the adoption of the
     Corporation's 1995 Non-Employee Directors' Incentive Plan;
 
          3. to consider and act upon  a proposal to confirm the appointment  of
     KPMG  Peat Marwick LLP  as the independent  certified public accountants of
     the Corporation for the current fiscal year; and
 
          4. to transact any such other business as may come before the  meeting
     or any adjournment or adjournments thereof.
 
     The Board of Directors has fixed the close of business on Friday, April 28,
1995,  as the record date for determining stockholders entitled to notice of and
to vote at the meeting.
 
     A proxy and return envelope are enclosed for your convenience.
 
     Directions to the  Somerset  Hills Hotel appear on the  back  cover of  the
Proxy Statement.
 
                                          By order of the Board of Directors,
                                          RICHARD G. WRIGHT,
                                          Chairman of the Board and
                                          Chief Executive Officer
 
April 28, 1995
 
                             YOUR VOTE IS IMPORTANT
                        Please mark, sign, and date the
                                    enclosed
                      proxy card and return it promptly in
                                  the enclosed
                       self-addressed, stamped envelope.

<PAGE>
                              CELGENE CORPORATION
                              7 POWDER HORN DRIVE
                            WARREN, NEW JERSEY 07059
 
                       ---------------------------------
                                PROXY STATEMENT
                       ---------------------------------
 
     This   Proxy  Statement  is  furnished   to  the  stockholders  of  Celgene
Corporation, a Delaware corporation (the 'Corporation'), in connection with  the
solicitation  of proxies by the Board of Directors for use at the annual meeting
of stockholders  of  the Corporation  to  be held  on  June 16,  1995,  and  any
adjournment or adjournments thereof. A copy of the notice of meeting accompanies
this Proxy Statement. It is anticipated that the mailing of this Proxy Statement
will commence on or about May 2, 1995.
 
     Only stockholders of record at the close of business on April 28, 1995, the
record  date for the meeting, will  be entitled to notice of  and to vote at the
meeting. On the record date the Corporation had outstanding 7,862,689 shares  of
common  stock, par value $.01 per share (the 'Common Stock'), which are the only
securities of the Corporation entitled to vote at the stockholders meeting, each
share being entitled to one vote.
 
     Stockholders who execute proxies may  revoke them by giving written  notice
to  the  Chief Executive  Officer of  the  Corporation at  any time  before such
proxies are  voted. Attendance  at the  meeting  shall not  have the  effect  of
revoking  a  proxy unless  the stockholder  so attending  shall, in  writing, so
notify the Secretary  of the  meeting at  any time prior  to the  voting of  the
proxy.
 
     The  Board of Directors does not know of  any matter that is expected to be
presented  for  consideration  at  the  meeting,  other  than  the  election  of
directors, approval of the adoption of the Celgene Corporation 1995 Non-Employee
Directors'  Incentive Plan (the '1995 Directors' Plan'), and the confirmation of
the appointment of  KPMG Peat Marwick  LLP as the  independent certified  public
accountants  of the Corporation  for the current fiscal  year. However, if other
matters properly come before the meeting, the persons named in the  accompanying
proxy intend to vote thereon in accordance with their judgment.
 
     The  Corporation  will  bear  the  cost of  the  meeting  and  the  cost of
soliciting proxies,  including  the  cost  of mailing  the  proxy  material.  In
addition  to solicitation by mail, directors, officers, and regular employees of
the Corporation (who will not be specifically compensated for such services) may
solicit proxies  by  telephone or  otherwise.  Arrangements will  be  made  with
brokerage  houses  and other  custodians, nominees,  and fiduciaries  to forward
proxies and  proxy  material  to  their principals,  and  the  Corporation  will
reimburse them for their expenses.
 
     All  proxies received pursuant to this solicitation will be voted except as
to matters where authority to vote is specifically withheld and, where a  choice
is  specified as  to the proposal,  they will  be voted in  accordance with such
specification. If no  instructions are  given, the  persons named  in the  proxy
solicited  by the Board of  Directors of the Corporation  intend to vote FOR the
nominees for  election  as  directors  of the  Corporation  listed  herein,  FOR
approval  of the adoption of the 1995  Directors' Plan, and FOR the confirmation
of the appointment  of KPMG  Peat Marwick  LLP as  independent certified  public
accountants  of the Corporation for the current  fiscal year. With regard to the
election of directors,  votes may  be cast  in favor  of or  withheld from  each
nominee;  votes that are  withheld will be  excluded entirely from  the vote and
will have no effect.  Abstentions may be specified  on all proposals except  the
election
 
<PAGE>
of  directors, and will  be counted as  present for purposes  of determining the
existence of a quorum regarding the item on which the abstention is noted.
 
     Pursuant to the  NASD Rules of  Fair Practice, brokers  who hold shares  in
street  name have  the authority, in  limited circumstances, to  vote on certain
items when they have not received instructions from beneficial owners. A  broker
will  only have such authority  if (i) the broker  holds the shares as executor,
administrator, guardian,  trustee, or  in  similar representative  or  fiduciary
capacity  with authority to  vote or (ii)  the broker is  acting pursuant to the
rules of any national securities exchange of which the broker is also a  member.
Under  applicable Delaware  law, a  broker non-vote will  have no  effect on the
outcome of  the election  of directors  and will  be the  equivalent of  a  vote
against  the adoption of the 1995 Directors' Plan but will be considered present
for purposes of determining a quorum.
 
                             PRINCIPAL STOCKHOLDERS
 
     The only person known by the Board of Directors to be the beneficial  owner
of more than five percent of the outstanding shares of Common Stock, as of March
31, 1995, is indicated below:
 
<TABLE>
<CAPTION>
                                                                       AMOUNT AND
                                                                       NATURE OF
                        NAME AND ADDRESS OF                            BENEFICIAL      PERCENT
                          BENEFICIAL OWNER                             OWNERSHIP       OF CLASS
- - --------------------------------------------------------------------   ----------      --------
 
<S>                                                                    <C>             <C>
Dimensional Fund Advisors Inc. .....................................     602,300(1)       7.7%
  1299 Ocean Avenue
  Santa Monica, CA 90401
</TABLE>
 
- - ------------
 
(1) Information  regarding  Dimensional Fund  Advisors Inc.  ('Dimensional') was
    determined according  to  a  Schedule  13G filed  with  the  Securities  and
    Exchange Commission. Dimensional, a registered investment advisor, is deemed
    to  be  the beneficial  ownership of  and have  sole dispositive  power over
    602,300 shares of Common Stock as of December 31, 1994. Such shares are held
    in  portfolios  of  DFA  Investment  Dimensions  Group  Inc.,  an   open-end
    investment  company registered under the Investment Company Act of 1940 (the
    'Fund'), series of  the DFA  Investment Trust Company,  a Delaware  business
    trust  (the 'Trust'),  or DFA  Group Trust  and the  DFA Participating Group
    Trust, investment vehicles for qualified  employee benefit plans, as to  all
    of  which Dimensional  serves as  investment manager.  Dimensional disclaims
    beneficial ownership of such shares. Persons who are officers of Dimensional
    also serve as  officers of  the Fund  and the  Trust. In  their capacity  as
    officers  of the Fund  and the Trust, these  persons vote 227,800 additional
    shares owned  by  the  Fund  and  4,800  shares  owned  by  the  Trust,  and
    Dimensional is deemed to have sole dispositive power over such shares.
 
                            ------------------------
 
     Except  as noted in the footnote above, (i) none of such shares is known by
the Corporation to be shares with respect to which the beneficial owner has  the
right  to acquire  beneficial ownership  and (ii)  the Corporation  believes the
beneficial holder listed above  has sole voting  and investment power  regarding
the shares shown as being beneficially owned.
 
                                       2
 
<PAGE>
                             ELECTION OF DIRECTORS
 
     At  the  meeting, six  Directors are  to  be elected,  each to  hold office
(subject to the Corporation's By-Laws) until  the next annual meeting and  until
his successor has been elected and qualified. If any nominee listed in the table
below  should  become  unavailable for  any  reason, which  management  does not
anticipate, the proxy will be voted  for any substitute nominee or nominees  who
may  be  selected by  the  management prior  to  or at  the  meeting, or,  if no
substitute is selected  by the  management prior  to or  at the  meeting, for  a
motion  to  reduce  the  membership  of the  Board  to  the  number  of nominees
available. Directors  will be  elected by  a plurality  of the  votes cast.  The
information  concerning  the  nominees  and  their  security  holdings  has been
furnished by them to the Corporation.
 
<TABLE>
<CAPTION>
                                                          PRINCIPAL OCCUPATION DURING
                                                            THE PAST FIVE YEARS, ANY                     YEAR FIRST
                                                        OFFICE HELD IN THE CORPORATION,                   ELECTED
              NAME                  AGE                     AND OTHER DIRECTORSHIPS                      A DIRECTOR
- - ---------------------------------   ---   ------------------------------------------------------------   ----------
<S>                                 <C>   <C>                                                            <C>
Richard G. Wright................   61    Chairman of the  Board and  Chief Executive  Officer of  the      1994
                                            Corporation  since  March  1994; Group  Vice  President of
                                            Storz Instrument  Company,  a pharmaceutical  and  medical
                                            device  company, from  1991 to  March 1994;  President and
                                            Chief  Executive  Officer  of   Xenon  Vision,  Inc.,   an
                                            ophthalmic  pharmaceutical  company,  from  1989  to 1991;
                                            President and  Chief  Operating Officer  of  Foster  Grant
                                            Corporation,  a  consumer products  company, from  1986 to
                                            1989.
Sol J. Barer.....................   47    President of the  Corporation since October  1993 and  Chief      1994
                                            Operating  Officer  of the  Corporation since  March 1994;
                                            Senior Vice President --  Science and Technology and  Vice
                                            President/General   Manager   Chiral   Products   of   the
                                            Corporation  from  October  1990  to  October  1993;  Vice
                                            President  -- Technology of the Corporation from September
                                            1987 to October 1990.
Frank T. Cary....................   74    Chairman of the Executive Committee of the Board since  June      1986
                                            1990;  Chairman of the Board  of the Corporation from July
                                            1986 to July 1990; Former Chairman of the Board and  Chief
                                            Executive   Officer  of  International  Business  Machines
                                            Corporation,   a   computer    and   business    equipment
                                            manufacturer,  from  1973  to  1981;  director  of Capital
                                            Cities/ABC  Inc.,  Cygnus  Therapeutic  Systems,  Lincare,
                                            Inc., ICOS Corporation, and SPS Transaction Services, Inc.
Richard C. E. Morgan.............   50    A  general partner  of Wolfensohn  Partners L.P.,  a venture      1987
                                            capital partnership and the general partner of  Wolfensohn
                                            Associates  L.P.,  since  1986; Chairman  and  director of
                                            MediSense, Inc.;  Chairman, Chief  Executive Officer,  and
                                            director  of  Lasertechnics,  Inc.;  director  of Liposome
                                            Technology Inc., and Quidel Corp.
</TABLE>
 
                                       3
 
<PAGE>
 
<TABLE>
<CAPTION>
                                                          PRINCIPAL OCCUPATION DURING
                                                            THE PAST FIVE YEARS, ANY                     YEAR FIRST
                                                        OFFICE HELD IN THE CORPORATION,                   ELECTED
              NAME                  AGE                     AND OTHER DIRECTORSHIPS                      A DIRECTOR
- - ---------------------------------   ---   ------------------------------------------------------------   ----------
<S>                                 <C>   <C>                                                            <C>
Walter L. Robb...................   66    Private consultant and President of Vantage Management Inc.,      1992
                                            a consulting and investor services company, since  January
                                            1993;  Senior  Vice President  for Corporate  Research and
                                            Development of General  Electric Company,  a consumer  and
                                            industrial  products company and broadcaster, and a member
                                            of its Corporate Executive  Council from 1986 to  December
                                            1992;  Chairman of the Board of Neopath, Inc.; director of
                                            Marquette Electronics, Inc. and Cree Research Inc.
Lee J. Schroeder.................   66    President   of   Lee    Schroeder   &   Associates,    Inc.,      1995
                                            pharmaceutical  business consultants, since 1985; director
                                            of FirsTier Bank Lincoln,  N.A., Harris Technology  Group,
                                            Inc.,  Bryan Memorial  Hospital, MGI  Pharma, Inc., Ascent
                                            Pharmaceuticals, and Interneuron Pharmaceuticals, Inc.
</TABLE>
 
BENEFICIAL OWNERSHIP OF DIRECTORS AND MANAGEMENT
 
     The table below sets forth the beneficial ownership of the Common Stock  as
of  March 31, 1995 (i) by each director,  (ii) by each of the executive officers
named in  the 'Summary  Compensation  Table,' and  (iii)  by all  directors  and
current executive officers of the Corporation as a group.
 
<TABLE>
<CAPTION>
                                                                                   AMOUNT AND NATURE OF
                                                                                  BENEFICIAL OWNERSHIP OF
                                                                                      COMMON STOCK AS        PERCENT
             NAME                                  POSITION                          OF MARCH 31, 1995       OF CLASS
- - ------------------------------  -----------------------------------------------   -----------------------    --------
 
<S>                             <C>                                               <C>                        <C>
Richard G. Wright.............  Chairman of the Board and Chief Executive                 100,000(1)            1.3%
                                  Officer
Sol J. Barer..................  President, Chief Operating Officer, and a                 122,182(1)            1.5%
                                  Director
Frank T. Cary.................  Director                                                   55,000(1)(2)        *
Richard C.E. Morgan...........  Director                                                  282,055(1)(2)(3)      3.6%
Walter L. Robb................  Director                                                   10,500(1)(2)        *
Lee J. Schroeder..............  Director                                                       --(2)           --
John L. Ufheil................  Former Chief Executive Officer and Chairman of            225,000               2.8%
                                  the Board
All directors and current executive
  officers of the Corporation as a group (six persons).........................           569,737(4)            7.0%
</TABLE>
 
- - ------------
 
*  Less than one percent (1%).
 
(1) Includes  shares of Common Stock which  the directors and executive officers
    had the right to acquire through the  exercise of options within 60 days  of
    March  31, 1995,  as follows:  Richard G. Wright  -- 100,000  shares; Sol J.
    Barer --  113,849 shares;  Frank  T. Cary  --  30,000 shares;  Richard  C.E.
    Morgan --
 
                                              (footnotes continued on next page)
 
                                       4
 
<PAGE>
(footnotes continued from previous page)
    25,000 shares; Walter L. Robb -- 6,000 shares; and John L. Ufheil -- 225,000
    shares.  Does not  include shares  of Common  Stock which  the directors and
    executive officers had the right to acquire through the exercise of  options
    not  exercisable within 60  days of March  31, 1995, as  follows: Richard G.
    Wright  --  50,000  shares;  Sol  J.  Barer  --  61,471  shares;  Frank   T.
    Cary  -- 5,000 shares;  Richard C.E. Morgan  -- 5,000 shares;  and Walter L.
    Robb -- 2,000 shares. Includes as to Dr. Barer, 8,333 shares of Common Stock
    subject to restricted stock awards. Includes as to Mr. Robb, 4,000 shares of
    Common Stock subject to restricted stock awards, 2,667 of which shares  were
    subject to forfeiture as of March 31, 1995.
 
(2) Excludes  as to  each of  Messrs. Cary,  Morgan, Robb,  and Schroeder 20,000
    shares of Common Stock  which the directors will  have the right to  acquire
    through  the exercise  of options  granted under  the 1995  Directors' Plan,
    which plan is subject to stockholder approval. See 'Approval of the Adoption
    of the 1995 Non-Employee Directors' Incentive Plan.'
 
(3) Includes 252,055 shares of Common Stock owned by Wolfensohn Associates L.P.,
    of which Wolfensohn Partners  L.P. is the general  partner. Mr. Morgan is  a
    general  partner of Wolfensohn Partners L.P. Mr. Morgan's indirect pecuniary
    interest in  such  shares  of  Common Stock,  within  the  meaning  of  Rule
    16a-1(a)(2)(ii)(B)   under  the   Securities  Exchange   Act  of   1934,  is
    significantly less than the amount disclosed. Mr. Morgan otherwise disclaims
    beneficial ownership  of such  shares of  Common Stock  owned by  Wolfensohn
    Associates L.P.
 
(4) Includes  or  excludes,  as the  case  may  be, shares  of  Common  Stock as
    indicated in the preceding footnotes.  Does not include shares  beneficially
    owned  by  John  L.  Ufheil,  who  currently  is  not  an  employee  of  the
    Corporation.
 
                            ------------------------
 
     Except as noted in the footnotes above, (i) none of such shares is known by
the Corporation to be shares with respect to which such beneficial owner has the
right to  acquire beneficial  ownership and  (ii) the  Corporation believes  the
beneficial  holders listed above have sole voting and investment power regarding
the shares shown as being beneficially owned by them.
 
DIRECTOR COMPENSATION
 
     Directors do not receive salaries or cash fees for serving as directors nor
do they receive any  cash compensation for serving  on committees; however,  all
members  of the  Board of  Directors who  are not  employees of  the Corporation
('Non-Employee Directors') are  reimbursed for their  expenses for each  meeting
attended  and  are  eligible  to  receive stock  options  pursuant  to  the 1995
Directors' Plan,  which  is subject  to  the  approval of  stockholders.  For  a
description  of the 1995 Directors'  Plan, see 'Approval of  the Adoption of the
1995 Non-Employee Directors' Incentive Plan.' Prior to the adoption of the  1995
Directors'  Plan,  the Non-Employee  Directors  were eligible  to  receive stock
options  and  restricted  stock  awards  pursuant  to  the  Corporation's   1992
Non-Employee Directors' Incentive Plan (the '1992 Directors' Plan'). If the 1995
Directors'  Plan is not approved by the  stockholders at the annual meeting, the
Non-Employee Directors will  continue to  receive options  and restricted  stock
awards under the 1992 Directors' Plan.
 
     Under  the 1992 Directors'  Plan, each new  Non-Employee Director, upon the
date of his election or appointment, receives a non-qualified option to purchase
8,000 shares of Common Stock and a
 
                                       5
 
<PAGE>
restricted stock award of 4,000 shares  of Common Stock. Additionally, upon  the
date  of each annual meeting of stockholders, each Non-Employee Director who has
served as a director of the Corporation for three years receives a non-qualified
option to purchase 5,000 shares of Common Stock, except that the Chairman of the
Board receives a non-qualified option to purchase 6,500 shares if he has been  a
Non-Employee  Director for three years. The  shares subject to an initial option
granted to  a  Non-Employee Director  vest  in four  equal  annual  installments
commencing  on  the  first  anniversary  of  the  date  of  grant,  assuming the
Non-Employee Director remains a director.  The shares subject to any  subsequent
option  granted to a Non-Employee Director vest in full on the date of the first
annual meeting of stockholders  held following the date  of grant, assuming  the
Non-Employee  Director has been a director  though that date. The exercise price
of such options is  equal to the fair  market value of the  Common Stock on  the
date of grant. The options expire no later than 10 years from the date of grant.
In  addition,  Common  Stock  awarded  to  Non-Employee  Directors  pursuant  to
restricted stock awards are subject to forfeiture under certain circumstances as
set forth under the 1992 Directors' Plan.
 
     Under both the 1995 Directors' Plan and the 1992 Directors' Plan (together,
the 'Directors' Plans'), if  a Non-Employee Director ceases  his service on  the
Board  of Directors for any reason, any exercisable option which has not expired
may be exercised at any  time until the date of  expiration of such option  with
respect  to the number of  shares of Common Stock  which were exercisable on the
date the Non-Employee Director terminated  his service with the Corporation.  In
addition,  if there is a change in  control (as defined in the Directors' Plans)
and within two years thereafter  a director ceases his  service on the Board  of
Directors  for any reason, all restrictions relating to a restricted stock award
automatically will  terminate (under  the  1992 Directors'  Plan only)  and  all
unvested portions of a stock option automatically will vest.
 
     In  1994, pursuant to  the 1992 Directors'  Plan, each of  Messrs. Cary and
Morgan received  an  option to  purchase  5,000 shares  of  Common Stock  at  an
exercise  price of $6.94  per share, the fair  market value of  the stock on the
date of grant.
 
BOARD COMMITTEES AND MEMBERSHIP
 
     The Corporation has an Executive Committee of the Board of Directors, whose
current members are Frank T. Cary,  Chairman, Richard C. E. Morgan, and  Richard
G. Wright. The Executive Committee did not meet in 1994. The Executive Committee
has  and may  exercise all  of the  powers and  authority of  the full  Board of
Directors of the Corporation, subject to certain exceptions.
 
     The  Corporation  has  an  Audit  Committee  of  the  Board  of  Directors,
consisting  entirely  of outside  directors, the  current  members of  which are
Walter L.  Robb, Chairman,  Frank T.  Cary, Richard  C. E.  Morgan, and  Lee  J.
Schroeder.  The Audit Committee held one meeting in 1994. The Board of Directors
has delegated to the  Audit Committee the following  duties: reviewing with  the
independent  auditors the plans  and results of  the audit engagement; reviewing
the adequacy,  scope,  and  results  of the  internal  accounting  controls  and
procedures;  reviewing the degree of independence of the auditors; reviewing the
auditors' fees; and recommending the engagement of auditors to the full Board of
Directors.
 
     The Corporation  has a  Management Compensation  and Development  Committee
(the  'Compensation Committee') of the Board of Directors, whose current members
are Richard C. E. Morgan,  Chairman, Frank T. Cary, Walter  L. Robb, and Lee  J.
Schroeder.   The  Compensation  Committee   held  two  meetings   in  1994.  The
Compensation Committee has  (i) the full  power and authority  to interpret  the
provisions  and  supervise the  administration of  the Corporation's  1986 Stock
Option Plan and 1992
 
                                       6
 
<PAGE>
Long-Term Incentive Plan and  to grant options outside  of these plans and  (ii)
the   authority  to  review  all  matters  relating  to  the  personnel  of  the
Corporation.
 
     The Corporation  does  not  have  a  nominating  committee.  The  Board  of
Directors  held five  meetings during  1994. During  1994, all  of the directors
attended more than 75% of the aggregate  of (i) the total number of meetings  of
the  Board of Directors and (ii) the  total number of meetings of all committees
of the Board of Directors on which such director served.
 
COMPLIANCE WITH SECTION 16(a) OF THE SECURITIES EXCHANGE ACT OF 1934
 
     Under  the  securities  laws  of  the  United  States,  the   Corporation's
directors,  executive officers, and any persons  holding more than 10 percent of
the Common Stock are required to report their ownership of Common Stock and  any
changes  in that ownership,  on a timely  basis, to the  Securities and Exchange
Commission. Based on  material provided  to the Corporation,  all such  required
reports  were filed on a timely basis in 1994 except for one report covering two
transactions required to be filed by Richard M. Clarke, a former director of the
Corporation, which report was filed one day past the due date.
 
                  EXECUTIVE COMPENSATION AND OTHER INFORMATION
 
SUMMARY OF CASH AND CERTAIN OTHER COMPENSATION
 
     The following table contains information about the compensation paid by the
Corporation for services rendered in all capacities during the three years ended
December 31, 1994 to  the Chief Executive Officer  of the Corporation, the  most
highly  paid  executive  officers  of  the  Corporation,  and  the  former Chief
Executive Officer.
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                                             LONG TERM COMPENSATION
                                                                                                     AWARDS
                                                                                ANNUAL       ----------------------
                                                                             COMPENSATION    RESTRICTED
                                                                             ------------       STOCK       OPTIONS/
                   NAME AND PRINCIPAL POSITION                       YEAR     SALARY ($)     AWARD(S)($)    SARS(#)
- - ------------------------------------------------------------------   ----    ------------    -----------    -------
<S>                                                                  <C>     <C>             <C>            <C>
Richard G. Wright ................................................   1994      $195,288(1)      --          150,000
  Chief Executive Officer and                                        1993        --             --            --
  Chairman of the Board                                              1992        --             --            --
Sol J. Barer .....................................................   1994      $197,000         --(3)        54,080
  President and Chief Operating Officer                              1993       180,000         --           30,000
                                                                     1992       167,833         --           22,500
John L. Ufheil ...................................................   1994      $ 96,000(2)      --            --
  Former Chief Executive Officer and                                 1993       288,400         --           25,000
  Chairman of the Board                                              1992       268,000         --            --
</TABLE>
 
- - ------------
 
(1) Mr. Wright  commenced his  employment with  the Corporation  in March  1994.
    Accordingly,  this number reflects a partial  year's salary and a relocation
    allowance in the amount of $18,750.
 
(2) Mr. Ufheil's  employment  with the  Corporation  terminated in  March  1994.
    Accordingly, this number reflects a partial year's salary.
 
(3) No  restricted stock awards were granted to  Dr. Barer during the last three
    years. As of December 31, 1994, Dr. Barer held 8,333 shares of Common  Stock
    subject to restricted stock awards, which
 
                                       7
 
<PAGE>
    awards were granted pursuant to the Corporation's 1986 Stock Option Plan. As
    of  December 31, 1994, the  fair market value of  the shares of Common Stock
    was $46,915.
 
EMPLOYMENT AGREEMENTS AND TERMINATION OF EMPLOYMENT ARRANGEMENTS
 
     Pursuant to his  employment arrangement  with the  Corporation, Richard  G.
Wright,  Chairman of the  Board and Chief Executive  Officer of the Corporation,
will receive $225,000 if he is terminated by the Corporation without cause.
 
     Sol J. Barer, President and Chief Operating Officer of the Corporation,  is
a  party to an  employment agreement with the  Corporation expiring in September
1996. Pursuant  to  such agreement,  Dr.  Barer  receives an  annual  salary  of
$200,000,   subject  to  increase  upon  annual  review.  Except  under  certain
circumstances, the  Corporation  may not  terminate  this agreement  without  12
months' prior notice to Dr. Barer. Pursuant to Dr. Barer's employment agreement,
he  will be  entitled to  receive a cash  payment equal  to 2.99  times his base
salary in the event of the termination of Dr. Barer's employment as a result  of
(i) his disability, (ii) the occurrence of certain events subsequent to a change
in  control of the Corporation (as defined  in such agreement), or (iii) certain
material breaches by the Corporation of such agreement.
 
     As described in footnote 1 to the table entitled 'Option/SAR Grants in Last
Fiscal Year,' if during the two-year period following a change in control of the
Corporation (as defined in the Corporation's 1992 Long-Term Incentive Plan), (i)
there is a change in an employee's  title or a significant change in the  nature
or  scope of his employment or duties  and such person terminates his employment
within 90 days following such change  or (ii) the recipient's employment by  the
Corporation  is terminated without  cause (as defined), then  all of the options
held by  such  employee  then  outstanding will  become  immediately  and  fully
exercisable,  and all restrictions applicable  to restricted stock automatically
will terminate.
 
STOCK OPTIONS
 
     The following table  contains information concerning  the grant of  options
during  the year ended December 31, 1994 to each of the executive officers named
in the 'Summary Compensation Table.' No stock appreciation rights ('SARs')  were
granted in 1994.
 
                     OPTION/SAR GRANTS IN LAST FISCAL YEAR
 
<TABLE>
<CAPTION>
                                                      INDIVIDUAL GRANTS
                                  ---------------------------------------------------------     POTENTIAL REALIZABLE
                                                   PERCENT OF                                     VALUE AT ASSUMED
                                                     TOTAL                                     ANNUAL RATES OF STOCK
                                                  OPTIONS/SARS                                 PRICE APPRECIATION FOR
                                                   GRANTED TO     EXERCISE OR                      OPTION TERM(5)
                                  OPTIONS/SARS    EMPLOYEES IN    BASE PRICE     EXPIRATION    ----------------------
             NAME                 GRANTED(#)(1)   FISCAL YEAR      ($/SHARE)        DATE        5% ($)      10% ($)
- - -------------------------------   ------------    ------------    -----------    ----------    --------    ----------
 
<S>                               <C>             <C>             <C>            <C>           <C>         <C>
Richard G. Wright..............      150,000(2)        35.8%         $6.88         3/01/04     $784,858    $1,986,013
Sol J. Barer...................       50,000(3)        11.9%          6.88         3/01/04      216,183       547,849
                                       4,080(4)         1.0%          8.38         3/24/04       21,489        54,458
John L. Ufheil.................       --             --              --             --            --           --
</TABLE>
 
                                                        (footnotes on next page)
 
                                       8
 
<PAGE>
(footnotes from previous page)
 
(1) The  exercisability of  these options  is dependent  on continued employment
    with the Corporation. Options were granted  at the fair market value of  the
    Common  Stock on  the date  of grant and  expire 10  years from  the date of
    grant. The option exercise price may be paid in shares of Common Stock owned
    by the executive  officer, in cash,  or in any  combination thereof. In  the
    event  of a  change in  control of the  Corporation, these  options may vest
    automatically  and  be  exercisable  immediately  in  full,  under   certain
    circumstances.   See  'Executive  Compensation   and  Other  Information  --
    Employment Agreements and Termination of Employment Arrangements.'
 
(2) These options are exercisable  as follows: 50,000 shares  on March 1,  1994;
    50,000 shares on March 1, 1995; and 50,000 shares on March 1, 1996.
 
(3) Twenty-five  thousand of these  options became exercisable  on March 1, 1995
    and twenty-five thousand options will become exercisable on March 1, 1996.
 
(4) These options will become exercisable as follows: 1,359 shares on March  24,
    1995; 1,360 shares on March 24, 1996; and 1,361 shares on March 24, 1997.
 
(5) The  potential realizable value represents the  estimated future gain in the
    value of the options over their  exercise price which may exist  immediately
    prior  to  the scheduled  expiration date  of  the options.  The calculation
    assumes the  specified compounded  rates of  appreciation in  the per  share
    price  of the Common Stock starting on the date of grant and further assumes
    that the options  will be  exercised on  their expiration  date. The  actual
    value,  if any, which may  be realized will depend  upon the market price of
    the Common Stock on the date the option is exercised. There is no  assurance
    that  the actual value, if any, which may be realized will be at or near the
    value estimated by the  calculations above. The market  price of the  Common
    Stock at December 31, 1994 was $5.63 per share.
 
                            ------------------------
 
     The  following table sets forth information with respect to the exercise of
options during 1994 and the options held as of December 31, 1994 by each of  the
executives  named in the 'Summary Compensation  Table.' There were no options or
SARs exercised during 1994 and as of December 31, 1994 no SARs were outstanding.
 
              AGGREGATED OPTION/SAR EXERCISES IN LAST FISCAL YEAR
                     AND FISCAL YEAR-END OPTION/SAR VALUES
 
<TABLE>
<CAPTION>
                                                                                NUMBER OF SHARES OF COMMON
                                                                               STOCK UNDERLYING UNEXERCISED
                                                                                  OPTIONS/SARS AT FISCAL
                                                                                     YEAR-END (#)(1)
                                                                               ----------------------------
                                    NAME                                       EXERCISABLE    UNEXERCISABLE
- - ----------------------------------------------------------------------------   -----------    -------------
 
<S>                                                                            <C>            <C>
Richard G. Wright...........................................................      50,000         100,000
Sol J. Barer................................................................      87,490          87,830
John L. Ufheil..............................................................     212,500          12,500
</TABLE>
 
                                                        (footnotes on next page)
 
                                       9
 
<PAGE>
(footnotes from previous page)
 
(1) None of  the options  held by  Mr. Wright,  Dr. Barer,  or Mr.  Ufheil  were
    in-the-money  as of December 31, 1994.  Options would have been in-the-money
    if the closing  market price of  the Common  Stock at December  31, 1994  of
    $5.63 per share exceeded the exercise price per share.
 
CERTAIN TRANSACTIONS
 
     For  a  discussion  of  certain  transactions  see  'Compensation Committee
Interlocks and Insider Participation.'
 
REPORT OF THE MANAGEMENT COMPENSATION AND DEVELOPMENT COMMITTEE
 
     The  Compensation   Committee   determines  the   Corporation's   executive
compensation policies. The Compensation Committee determines the compensation of
the   Corporation's   executive   officers  and   approves   and   oversees  the
administration of incentive  compensation programs for  all employees  including
the executive officers. The Compensation Committee is composed solely of outside
directors.
 
EXECUTIVE COMPENSATION POLICIES AND PROGRAMS
 
     The  Corporation's executive compensation program is part of a company-wide
program covering all employees. The program's goals are to attract, retain,  and
motivate   employees,  and  it  utilizes  incentives  such  that  employees  and
stockholders share the same risks. The compensation program is designed to  link
compensation  to performance. A portion  of each employee's compensation relates
to the grant  of stock  options, and  such grants  are based  on the  successful
attainment  of strategic corporate, business unit,  and individual goals. As the
Corporation has not as yet  attained significant commercial revenues, goals  are
set which relate to the successful attainment of strategic events.
 
     The  Corporation does not have a pension plan or other capital accumulation
program. Grants of stock options are therefore of great importance to executives
as well as all  employees. Any value  to be derived  long-term from such  grants
will be consistent with stockholder gains.
 
     Executive  and  employee compensation  includes  salary, employment-related
benefits, and long-term incentive compensation:
 
     Salary.  Salaries  are   set  competitively  relative   to  the   chemical,
biotechnology,  and  pharmaceutical  industries  --  industries  with  which the
Corporation competes for its highly skilled personnel. Individual experience and
performance is  considered  when setting  salaries  within the  range  for  each
position.  Annual reviews are held and  adjustments are made based on attainment
of individual goals.
 
     Benefits. All employees are eligible for similar benefits, such as  health,
disability, and life insurance.
 
     Long-Term  Incentive  Compensation.  An incentive  compensation  program is
established annually.  The  purpose of  this  program is  to  provide  financial
incentives  to executives  and employees  to achieve  annual corporate, business
unit, and  individual goals.  The incentive  program also  aligns executive  and
employee  interests with those of stockholders by using grants of stock options.
Such grants vest  over time  thereby encouraging continued  employment with  the
Corporation.  The size of  grants is tied  to comparative biotechnology industry
practices. To determine such comparative data, the Corporation relies on outside
compensation consultants, the Corporation's  auditors, and third party  industry
surveys.
 
     Under  the Corporation's 1994 incentive program,  it was agreed, subject to
the  achievement  of  certain  goals  in  1994  by  the  Corporation,  that  the
Corporation would grant at a future date options to
 
                                       10
 
<PAGE>
purchase   shares  of  Common  Stock.  Based  upon  achievement  of  Corporation
objectives in 1994, approximately  78,868 options were  granted on February  15,
1995  to employees other than the executive officers of the Corporation. Options
were granted at an exercise  price of $5.44 which was  equal to the fair  market
value  of  the Common  Stock at  the date  of  grant. Such  options vest  over a
four-year period.
 
     A similar incentive program has been designed for 1995 based on  attainment
of  corporate, business unit, and  individual goals. The program  is open to all
regular  full-time  employees,  other  than   the  executive  officers  of   the
Corporation.
 
     Chief  Executive Officer  Compensation. During  1994, Mr.  Ufheil served as
Chairman and Chief Executive Officer of the Corporation until March 18, 1994, at
which time  Richard  G.  Wright  assumed the  position  of  Chairman  and  Chief
Executive  Officer. Pursuant to  his employment agreement  with the Corporation,
Mr. Ufheil  received $96,000  for the  period during  which he  served as  Chief
Executive Officer. Mr. Ufheil did not participate in the 1994 incentive program.
 
     Mr. Wright's arrangement with the Corporation provides for an annual salary
of  $225,000. During 1994, Mr. Wright  received $195,288 in salary, which amount
includes an $18,750 relocation allowance. Mr. Wright did not participate in  the
1994  incentive program and is not eligible to participate in the 1995 incentive
program. However, Mr.  Wright's long-term  incentive derives from  the grant  of
options to purchase 150,000 shares of Common Stock awarded to him at the time he
began serving as Chief Executive Officer, 100,000 of which are vested and 50,000
of which will vest in March 1996.
 
                                          Members of the Management Compensation
                                          and Development Committee
 
                                          RICHARD C. E. MORGAN, Chairman
                                          FRANK T. CARY
                                          WALTER L. ROBB
 
Lee  J. Schroeder was  appointed to the  Management Compensation and Development
Committee  on  March  22,  1995,  and  therefore  did  not  participate  in  the
discussions  and  determinations  contained  in this  Report  of  the Management
Compensation and Development Committee.
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     The current members of the Compensation Committee are Richard C. E. Morgan,
Chairman, Frank T. Cary,  Walter L. Robb,  and Lee J.  Schroeder. Richard C.  E.
Morgan  is a general partner  of Wolfensohn Partners L.P.,  which is the general
partner of Wolfensohn Associates L.P. In connection with the purchase of  Common
Stock  in  a  private placement  in  1986, Wolfensohn  Associates  L.P. received
certain demand and 'piggyback'  registration rights with  respect to the  Common
Stock purchased by them under certain conditions.
 
PERFORMANCE GRAPH
 
     The  following chart shows changes over the past five years in the value of
$100 invested in: (1) the Corporation's Common Stock; (2) the Standard &  Poor's
500  Index; (3) the  Specialty Chemicals Industry Index  published by Standard &
Poor's; and (4) the NASDAQ Pharmaceutical Index.
 
     The Corporation  has  included  the  NASDAQ  Pharmaceutical  Index  in  the
following  chart because of  the changing nature of  its business from specialty
chemical to pharmaceutical as a result of the Corporation's focus on its  chiral
and  immunotherapeutic programs. The Corporation intends to delete the Specialty
Chemicals Industry Index in future proxy statements.
 
                                       11
 
<PAGE>


                       FIVE-YEAR CUMULATIVE TOTAL RETURNS
                 Value of $100 Invested on December 31, 1989

                             [PERFORMANCE GRAPH]

<TABLE>
<CAPTION>
                                        FISCAL YEAR ENDING DECEMBER 31
                                 1989    1990    1991    1992    1993    1994
<S>                              <C>     <C>     <C>     <C>     <C>     <C>
- - -----------------------------------------------------------------------------
Celgene Corp                      100      87     203     175      93      75
S&P 500                           100      97     126     136     150     152
S&P Specialty Chemical            100     102     144     153     174     152
NASDAQ Pharm                      100     120     319     266     237     178
</TABLE>

                       APPROVAL OF THE ADOPTION OF THE 1995
                     NON-EMPLOYEE DIRECTORS' INCENTIVE PLAN
 
GENERAL
 
     The following description of the 1995  Directors' Plan is a summary and  is
qualified  in its entirety  by reference to  the 1995 Directors'  Plan, which is
attached hereto as Exhibit A.
 
     The 1995 Directors' Plan was adopted by the Board of Directors on April  5,
1995,  subject  to  the approval  of  the Corporation's  stockholders.  The 1995
Directors' Plan provides for the  granting of non-qualified options to  purchase
an  aggregate of not more than 250,000  shares (subject to adjustment in certain
circumstances) of Common  Stock to Non-Employee  Directors. The 1995  Directors'
Plan  is designed  to provide  a means of  giving existing  and new Non-Employee
Directors an increased opportunity to acquire an investment in the  Corporation,
thereby   maintaining  and  strengthening  their   desire  to  remain  with  the
Corporation's  Board  of  Directors  and   stimulating  their  efforts  on   the
Corporation's  behalf. It  is also expected  that the 1995  Directors' Plan will
encourage qualified persons to become directors of the Corporation.
 
     Non-Employee Directors, including  members of  the Compensation  Committee,
are  eligible to  receive options under  the 1995 Directors'  Plan in accordance
with the terms of the 1995 Directors' Plan. Each new Non-Employee Director, upon
the   date   of   his   election   or   appointment,   will   receive   a   non-
 
                                       12
 
<PAGE>
qualified option to purchase 20,000 shares of Common Stock. Upon the date of the
1995  Annual Meeting  of Stockholders  and the  approval of  the 1995 Directors'
Plan, each Non-Employee Director who is  reelected and continues as a member  of
the  Board of  Directors will receive  a non-qualified option  to purchase 6,000
shares of Common Stock. Upon the date of the Annual Meeting of Stockholders each
year after 1995, each Non-Employee Director who is reelected and continues as  a
member of the Board of Directors will receive a non-qualified option to purchase
10,000 shares of Common Stock (or a pro rata portion thereof if the director did
not  serve  the  entire  year  since  the  date  of  the  last  annual meeting).
Additionally, each Non-Employee Director  as of April 5,  1995, the date of  the
adoption  of the  1995 Directors'  Plan, was  granted a  non-qualified option to
purchase 20,000  shares  of  Common  Stock,  subject  to  the  approval  of  the
stockholders of the Corporation of the 1995 Directors' Plan.
 
     The  shares subject to an initial option granted to a Non-Employee Director
and the shares subject to the options granted on the date of the adoption of the
1995 Directors' Plan vest  in four equal annual  installments commencing on  the
first  anniversary  of the  date of  grant,  assuming the  Non-Employee Director
remains a director. The 6,000 or 10,000 shares subject to any subsequent  option
granted  to a Non-Employee Director  will vest in full on  the date of the first
Annual Meeting of Stockholders  held following the date  of the grant,  assuming
the Non-Employer Director has been a director through that date.
 
     The  options will expire no later than 10  years from the date of grant and
no options may be granted after April 5, 2005.
 
     If a Non-Employee Director terminates his service on the Board of Directors
for any reason, any exercisable option which has not expired may be exercised at
any time until the date of expiration of such option with respect to the  number
of  shares of Common Stock  which were exercisable on  the date the Non-Employee
Director terminated his service with the Corporation. In addition, if there is a
change in control (as defined in the 1995 Directors' Plan) and within two  years
thereafter  a director  ceases his  service on  the Board  of Directors  for any
reason, all unvested portions of a stock option will automatically vest.
 
     The 1995 Directors' Plan  is administered by the  Board of Directors  which
has  the full and final  authority to interpret the  1995 Directors' Plan and to
adopt and amend such  rules and regulations for  the administration of the  1995
Directors'  Plan as  the Board  may deem  desirable. In  addition, the  Board of
Directors has the right to amend, suspend, or terminate the 1995 Directors' Plan
at any time; provided, however, that  unless first duly approved by the  holders
of  Common Stock entitled to vote thereon, no amendment or change may be made in
the 1995 Directors' Plan: (i) increasing the maximum number of shares for  which
options  may  be granted  under the  1995 Directors'  Plan; (ii)  increasing the
number of  shares  subject to  an  option;  (iii) reducing  the  purchase  price
previously  specified  for the  shares subject  to  options; (iv)  extending the
period during which options may be  granted or options exercised under the  1995
Directors'  Plan;  or (v)  changing  the class  of  persons eligible  to receive
options under the 1995 Directors' Plan.
 
     Any options granted under the 1995 Directors' Plan prior to the date of the
Annual Meeting  of  Stockholders will  terminate  in  the event  that  the  1995
Directors'  Plan is not approved by the  stockholders of the Corporation. If the
1995 Directors'  Plan is  not  approved by  the stockholders,  the  Non-Employee
Directors  will continue to receive options  under the 1992 Directors' Plan. See
'Election of Directors -- Director Compensation'  for a description of the  1992
Directors' Plan. If the 1995
 
                                       13
 
<PAGE>
Directors'  Plan  is  approved  by  the  stockholders  of  the  Corporation,  no
additional options or  restricted stock awards  will be granted  under the  1992
Directors' Plan.
 
     The  1995 Directors' Plan is not subject  to any of the requirements of the
Employee Retirement Income Security Act of 1974, as amended. The 1995 Directors'
Plan is not, nor  is it intended  to be, qualified under  Section 401(a) of  the
Code.  Options granted  under the 1995  Directors' Plan  will be 'non-qualified'
stock options and are not intended  to qualify as incentive stock options  under
Section 422A of the Code.
 
CERTAIN FEDERAL INCOME TAX CONSEQUENCES
 
     The principal Federal income tax consequences with respect to stock options
granted  or to be  granted pursuant to  the 1995 Directors'  Plan are summarized
below. The  following discussion  does not  set  forth any  state or  local  tax
consequences   that  may  be   applicable.  Individuals  are   urged  to  obtain
professional advice regarding the applicability of federal, state, and local tax
laws to them.
 
     The options granted or to be granted under the 1995 Directors' Plan do  not
and  will not qualify as  incentive stock options and  are herein referred to as
non-qualified stock options. An optionee will  realize no income at the time  he
is  granted a non-qualified  stock option. Such conclusion  is predicated on the
assumption that, under existing Treasury Department regulations, a non-qualified
stock option, at the time of its grant, has no readily ascertainable fair market
value. Except with respect to the  exercise of a non-qualified stock option  for
stock  which  is  'not  transferable'  and subject  to  a  'substantial  risk of
forfeiture,' as described below,  ordinary income will be  realized when a  non-
qualified  stock option is exercised. The amount of such income will be equal to
the excess of the fair market value on the exercise date of the shares of Common
Stock issued to an optionee over the option price. The optionee's holding period
with respect to the shares acquired will begin on the date of exercise.
 
     Special rules  are applicable  to  stock which  is 'not  transferable'  and
subject  to a 'substantial  risk of forfeiture.'  In general, such  stock (i) is
subject to a  substantial risk  of forfeiture if  the optionee's  right to  full
enjoyment of the stock is conditioned upon the future performance of substantial
services  and (ii)  is not  transferable if  a transferee  would take  the stock
subject to the same restrictions. Stock acquired pursuant to the exercise of  an
option as to which a service requirement is imposed could be so treated.
 
     Unless  the optionee elects to be taxed  at the time of exercise (an '83(b)
election'), the optionee will  recognize ordinary income on  the first day  that
the  stock  is either  transferable  or not  subject  to a  substantial  risk of
forfeiture. In the  case of any  other stock subject  to a service  requirement,
this  will depend on the individual facts and circumstances. The ordinary income
in such case will be the  excess of the fair market  value of the stock on  such
date  over the option price and the optionee's holding period will begin on that
day.
 
     An optionee who makes an 83(b)  election will recognize ordinary income  on
the  date of exercise equal to the excess of the fair market value of such stock
at the time  of exercise over  the option price.  The optionee's holding  period
with respect to such stock will begin on the date of exercise.
 
     The tax basis of the stock acquired upon the exercise of any option will be
equal  to the sum of (i)  the exercise price of such  option and (ii) the amount
included in income with respect to such option. Any gain or loss on a subsequent
sale of the stock will be either  long-term or short-term capital gain or  loss,
depending on the optionee's holding period for the stock disposed of.
 
                                       14
 
<PAGE>
     In  addition,  any officers  and directors  of  the Corporation  subject to
Section 16(b) of the Securities Exchange Act  of 1934 may be subject to  special
tax  rules regarding the income  tax consequences concerning their non-qualified
options. A participant subject  to Section 16(b) should  consult his or her  tax
advisor  as to whether, as a result  of Section 16(b) of the Securities Exchange
Act of 1934  and Section 83  of the  Internal Revenue Code  and the  regulations
thereunder, the timing of income recognition is deferred to any period following
exercise of an option (e.g., the six-month period following such exercise).
 
     The Corporation will be entitled, subject to rules regarding reasonableness
of compensation, to a deduction for Federal income tax purposes at the same time
and  in the same amount as the  optionee is considered to have realized ordinary
income in connection  with the  exercise of the  option. The  deduction will  be
allowed  for the taxable year of the Corporation in which or with which ends the
taxable year of the optionee in which such ordinary income is recognized.
 
NEW PLAN BENEFITS
 
     On April 5, 1995, the date the 1995 Directors' Plan was adopted (subject to
stockholder approval), each  of Messrs.  Cary, Morgan, Robb,  and Schroeder  was
granted under the 1995 Directors' Plan a non-qualified option to purchase 20,000
shares of Common Stock. These options have an exercise price of $5.63 per share,
the fair market value of the Common Stock on the date of grant, and vest in four
equal  annual installments  commencing on the  first anniversary of  the date of
grant. On April 24, 1995,  the closing price of the  Common Stock was $5.38  per
share.
 
VOTE REQUIRED
 
     The  affirmative  vote  of  the  holders of  at  least  a  majority  of the
outstanding shares of Common  Stock present and entitled  to vote at the  annual
meeting  is required to  approve the adoption  of the 1995  Directors' Plan. THE
BOARD OF DIRECTORS RECOMMENDS  THAT THE STOCKHOLDERS VOTE  THEIR SHARES FOR  THE
PROPOSAL TO APPROVE THE ADOPTION OF THE 1995 DIRECTORS' PLAN.
 
                              INDEPENDENT AUDITORS
 
     The  Board of  Directors has appointed  KPMG Peat  Marwick LLP, independent
certified public accountants, to audit the books and records of the  Corporation
for  the current  year, and  the Board recommends  that the  stockholders of the
Corporation confirm such appointment.
 
     Representatives of KPMG Peat Marwick LLP are expected to be present at  the
meeting  of stockholders and will be given an opportunity to make a statement if
they so desire.  They are  expected to be  available to  respond to  appropriate
questions.
 
                                       15
 
<PAGE>
                             STOCKHOLDERS PROPOSALS
 
     Stockholders  of the Corporation wishing to  include proposals in the proxy
material in relation to the annual meeting of the Corporation to be held in 1996
must submit the same in writing so as to be received at the executive office  of
the  Corporation on or before  December 28, 1995. Such  proposals must also meet
the other requirements of  the rules of the  Securities and Exchange  Commission
relating to stockholders' proposals.
 
                                          By Order of the Board of Directors,
                                          RICHARD G. WRIGHT,
                                          Chairman of the Board and
                                          Chief Executive Officer
 
April 28, 1995
 
                                       16

<PAGE>
                                                                       EXHIBIT A
 
                              CELGENE CORPORATION
                  1995 NON-EMPLOYEE DIRECTORS' INCENTIVE PLAN
 
1. PURPOSE
 
     The  purpose  of  the  Celgene  Corporation  1995  Non-Employee  Directors'
Incentive  Plan  (the  'Plan')  is  to  secure  for  Celgene  Corporation   (the
'Corporation')  and its stockholders  the benefits of  the incentive inherent in
increased ownership  of common  stock, par  value $.01  per share  (the  'Common
Stock'),  of  the Corporation  by the  members  of the  Board of  Directors (the
'Board') of the Corporation who are not  employees of the Corporation or any  of
its  subsidiaries ('Non-Employee Directors'). It is expected that such ownership
will provide such Non-Employee Directors with a more direct stake in the  future
welfare  of  the  Corporation and  encourage  them  to remain  directors  of the
Corporation. It is also expected that the Plan will encourage qualified  persons
to become directors of the Corporation.
 
2. ADMINISTRATION
 
     The  Plan shall be administered by  the Board, and in connection therewith,
the Board shall  have all  the powers vested  in it  by the terms  of the  Plan,
including  authority (within the limitations  described herein) to prescribe the
form of the  agreements embodying awards  of stock options  made under the  Plan
(the 'Options'). Subject to the provisions of the Plan, the Board shall have the
power  to construe the Plan, to determine  all questions arising under the Plan,
and to adopt and amend such rules and regulations for the administration of  the
Plan  as it may deem desirable. Any  decision of the Board in the administration
of the Plan, as described herein, shall  be final and conclusive. The Board  may
act only by a majority of its members in office, except that the members thereof
may  authorize any  one or more  of their number  or the Secretary  or any other
officer of the  Corporation to execute  and deliver documents  on behalf of  the
Board. No member of the Board shall be liable for anything done or omitted to be
done  by such member or by any other  member of the Board in connection with the
Plan, except for such member's own  willful misconduct or as expressly  provided
by statute.
 
3. AMOUNT OF STOCK
 
     The  stock which may be  issued or transferred pursuant  to the exercise of
Options granted under the Plan shall not exceed 250,000 shares of Common  Stock,
subject  to adjustment as provided  in Section 9. The  Common Stock to be issued
may be  either  authorized  and  unissued shares  or  previously  issued  shares
acquired  or to be acquired by the  Corporation and held in treasury. Any shares
subject to an Option which for  any reason expires or is terminated  unexercised
may again be subject to a new Option.
 
4. ELIGIBILITY
 
     Each Non-Employee Director shall be eligible to receive non-qualified stock
options  in accordance with Section 5. Options granted under the Plan shall each
be evidenced by an agreement in such form as the Board shall prescribe from time
to time in accordance with the Plan.
 
                                      A-1
 
<PAGE>
5. GRANT OF OPTIONS
 
     Each Option automatically shall be granted in accordance with the following
terms and conditions:
 
          (a) upon the  date of the  approval of  this Plan by  the Board,  each
     Non-Employee  Director shall receive an Option to purchase 20,000 shares of
     Common Stock, subject to adjustment as provided in Section 9;
 
          (b) upon the date  of initial election or  appointment as a member  of
     the  Board,  each  new Non-Employee  Director  shall receive  an  Option to
     purchase 20,000 shares of Common  Stock, subject to adjustment as  provided
     in Section 9;
 
          (c)  upon  the  date of  the  Annual  Meeting of  Stockholders  of the
     Corporation to be held on June 16, 1995 (the '1995 Annual Meeting') or  any
     adjournment  or adjournments  thereof, each  Non-Employee Director  who has
     been reelected at the 1995 Annual Meeting and is continuing as a member  of
     the  Board as of the completion of the 1995 Annual Meeting shall receive an
     Option to purchase 6,000 shares of  Common Stock, subject to adjustment  as
     provided in Section 9; and
 
          (d)  each year  after the  1995 Annual  Meeting, upon  the date  of an
     Annual Meeting of  Stockholders of  the Corporation  (an 'Annual  Meeting')
     each  Non-Employee Director who  has been reelected  at such Annual Meeting
     and is continuing as  a member of  the Board as of  the completion of  such
     Annual  Meeting shall receive an Option to purchase 10,000 shares of Common
     Stock, subject to adjustment as  provided in Section 9; provided,  however,
     that  a Non-Employee Director who has been reelected at such Annual Meeting
     and is continuing as  a member of  the Board as of  the completion of  such
     Annual  Meeting but has  not been a  member of the  Board during the entire
     period between  such Annual  Meeting  and the  prior Annual  Meeting  shall
     receive an Option to purchase that number of shares equal to the product of
     (i)  10,000 and (ii) a fraction, where  the numerator is the number of days
     in the 12-month  period immediately  preceding such  Annual Meeting  during
     which  such  Non-Employee  Director  was a  Non-Employee  Director  and the
     denominator is 365.
 
6. EXERCISE PRICE
 
     The Option exercise price per share shall be 100% of the fair market  value
of  a share  of Common  Stock on  the date  of grant,  subject to  adjustment as
provided in Section 9. As  used herein, fair market  value shall be the  closing
price  of the Common Stock on the date  of determination (if the Common Stock is
then traded on a national securities  exchange or in the NASDAQ National  Market
System)  or, if not so  traded, the average of the  closing bid and asked prices
thereof on  such day  or, if  the Common  Stock is  not traded  on the  date  of
determination, on the last preceding date on which the Common Stock is traded.
 
7. EXERCISE OF OPTIONS
 
     (a) No Option shall be exercisable until and unless the Plan is approved by
the  Corporation's stockholders at the 1995  Annual Meeting and, unless the Plan
is so approved, all Options will terminate and be of no further force or  effect
on  the earlier to occur of  (i) the day after the  1995 Annual Meeting and (ii)
April 4, 1996.
 
     (b) The shares  subject to an  Option granted pursuant  to Section 5(a)  or
5(b)  shall vest in  four equal annual installments,  with the first installment
vesting  on   the   first   anniversary   of  the   date   of   grant   if   the
 
                                      A-2
 
<PAGE>
holder  thereof has been a Non-Employee Director of the Corporation at all times
since such date of grant.  The shares subject to  an Option granted pursuant  to
Section  5(c) or 5(d) shall vest in full on the date of the first Annual Meeting
held following the date of grant if  the holder thereof has been a  Non-Employee
Director  of the Corporation at all times from such date of grant to the date of
such Annual Meeting.
 
     (c) If a person shall  cease to be a  Non-Employee Director for any  reason
('Termination')  while holding an Option  that has not expired  and has not been
fully exercised, such person, or in the case of his or her death or adjudication
of incompetency, his or  her executors, administrators, distributees,  guardian,
or  legal  representative,  as the  case  may be,  may,  at any  time  until the
termination of such Option,  exercise the Option with  respect to any shares  of
Common  Stock as to which it was exercisable on the date the person ceased to be
such a Non-Employee Director.
 
     (d) No Option or any part of an Option shall be exercisable:
 
          (i) after the  expiration of  10 years from  the date  the Option  was
     granted; and
 
          (ii)  unless  written  notice  of the  exercise  is  delivered  to the
     Corporation specifying the number of shares to be purchased, and payment in
     full is made for  the shares of Common  Stock being acquired thereunder  at
     the time of exercise.
 
     (e)  An Option shall not be transferable  by the optionee otherwise than by
will or the laws of descent and distribution or pursuant to a qualified domestic
relations order, as  defined in the  Internal Revenue Code  of 1986, as  amended
(the  'Code'),  and  shall  be  exercisable during  this  lifetime  only  by the
optionee, his or her guardian or legal representative, or the recipient  thereof
pursuant to a qualified domestic relations order.
 
8. ACCELERATION OF VESTING
 
     (a)  If Termination occurs  within two years following  a Change in Control
(as defined in Section 8(b) hereof), an Option shall automatically be vested and
immediately exercisable in full. In  such event, notwithstanding the  provisions
of  Section  7, an  Option recipient,  or in  the case  of his  or her  death or
adjudication  of   incompetency,   his   or   her   executors,   administrators,
distributees, guardian, or legal representative, as the case may be, may, at any
time  until the termination of  such Option, purchase some  or all of the shares
covered by such recipient's Options.
 
     (b) For the purposes  hereof, a change in  control (a 'Change in  Control')
shall be deemed to occur:
 
          (i)  if any person within  the meaning of Sections  13(d) and 14(d) of
     the Securities Exchange Act of 1934,  other than the Corporation or any  of
     its  subsidiaries, has become  the beneficial owner,  within the meaning of
     Rule 13d-3 under the Securities Exchange Act of 1934, of 30 percent or more
     of the combined voting power  of the Corporation's then outstanding  voting
     securities; or
 
          (ii) when a majority of the directors elected at any special or annual
     meeting  of stockholders are not individuals nominated by the Corporation's
     incumbent Board or when individuals who are members of the Board at any one
     time shall immediately  thereafter cease  to constitute a  majority of  the
     Board.
 
9. ADJUSTMENTS UPON CHANGES IN CAPITALIZATION
 
     (a)  If dividends  payable in  Common Stock during  any fiscal  year of the
Corporation  exceed  in  the  aggregate  5%  of  the  Common  Stock  issued  and
outstanding    at    the    beginning    of   such    fiscal    year,    or   if
 
                                      A-3
 
<PAGE>
there is  during  any  fiscal  year  of the  Corporation  one  or  more  splits,
subdivisions, or combinations of shares of Common Stock resulting in an increase
or  decrease by more than  5% of the shares outstanding  at the beginning of the
year, the  number of  shares subject  to  Options to  be granted  thereafter  to
Non-Employee  Directors pursuant  to Section 5  shall be  increased or decreased
proportionately, as the case may be,  and the number of shares deliverable  upon
the exercise thereafter of any Options theretofore granted shall be increased or
decreased  proportionately, as the case may  be, without change in the aggregate
purchase price. Common  Stock dividends, splits,  subdivisions, or  combinations
during  any fiscal year  which do not exceed  in the aggregate  5% of the Common
Stock issued and outstanding at the beginning of such year shall be ignored  for
purposes  of the Plan. All  adjustments shall be made as  of the day such action
necessitating such adjustment becomes effective.
 
     (b) In  case  the  Corporation  is  merged  or  consolidated  with  another
corporation, or in case all or substantially all of the property or stock of the
Corporation  is acquired by another corporation,  or in case of a reorganization
or liquidation of the Corporation, the Board,  or the board of directors of  any
corporation  assuming the obligations of the Corporation hereunder, shall either
(i) make appropriate provisions for the protection of any outstanding Options by
the substitution on an equitable basis of appropriate stock of the  Corporation,
or  appropriate  stock of  the  merged, consolidated,  or  otherwise reorganized
corporation or (ii) give written notice  to optionees that their Options,  which
will become immediately exercisable notwithstanding any waiting period otherwise
prescribed  by the Board, must  be exercised within 30 days  of the date of such
notice or they will be terminated.
 
10. MISCELLANEOUS PROVISIONS
 
     (a) Except as expressly provided for in the Plan, no Non-Employee  Director
or  other person shall have any claim or right to be granted an Option under the
Plan.
 
     (b) Nothing in the Plan or in  any Option agreement shall confer any  right
to  continue as a director  of the Corporation or interfere  in any way with the
right of the Corporation to  remove such option holder  or not to nominate  such
option holder for election as a director of the Corporation at any time.
 
     (c)  The Corporation shall not be obligated to deliver any shares of Common
Stock hereunder until there has been qualification under or compliance with such
state or  federal  laws,  rules  or regulations  as  the  Corporation  may  deem
applicable.
 
     (d) Stock purchased pursuant to the exercise of an Option shall at the time
of  purchase be  paid in  full in  cash, or  with shares  of Common  Stock, or a
combination of cash  and Common  Stock to  be valued  at the  fair market  value
thereof  on the  date of  such exercise; provided,  however, that  any shares of
Common Stock so delivered shall have been beneficially owned by the optionee for
a period of not less than six months prior to the date of exercise. Upon receipt
of payment  and such  documentation as  the Corporation  may deem  necessary  to
establish  compliance with  the Securities Act  of 1933,  the Corporation shall,
without stock transfer tax to the optionee or other person entitled to  exercise
the  Option,  deliver  to the  person  exercising  the Option  a  certificate or
certificates for such shares. It shall be a condition to the obligations of  the
Corporation  to issue  or transfer  shares of Common  Stock upon  exercise of an
Option, that the optionee (or any person entitled to act under Sections 7(c) and
7(e)) pay to the Corporation,  upon its demand, such amount,  if any, as may  be
requested  by the  Corporation for  the purpose  of satisfying  any liability to
withhold federal, state, local or foreign  income or other taxes. If the  amount
requested  is not  paid, the  Corporation may refuse  to issue  shares of Common
Stock. Such taxes may be paid in cash  or by tender of the option holder or  the
withholding by the Corporation of
 
                                      A-4
 
<PAGE>
the  number of shares of Common Stock  whose fair market value equals the amount
required to be withheld.
 
     (e) A  recipient of  Options shall  have no  rights as  a stockholder  with
respect  to any shares issuable or  transferable upon exercise thereof until the
date a stock certificate is issued to  him for such shares. Except as  otherwise
expressly  provided in the  Plan, no adjustment  shall be made  for dividends or
other rights  for  which  the record  date  is  prior to  the  date  such  stock
certificate is issued.
 
     (f) The expenses of the Plan shall be borne by the Corporation.
 
     (g)  If an Option is exercised  by the executors, administrators, legatees,
or distributees of the estate of a deceased optionee or by the guardian or legal
representative of an optionee, the Corporation  shall be under no obligation  to
issue  stock thereunder unless  and until the Corporation  is satisfied that the
person  or  persons  exercising  the   Option  are  the  duly  appointed   legal
representatives  of the  optionee or  of the  deceased optionee's  estate or the
proper legatees or distributees of such estate.
 
11. AMENDMENT OR DISCONTINUANCE
 
     The Plan may be  amended at any time  and from time to  time, but not  more
than  once in a six-month period, by the Board as the Board shall deem advisable
including, but not limited to, amendments necessary to qualify for any exemption
or to comply with applicable law or regulations; provided, however, that  except
as  provided in Section  9, the Board  may not, without  further approval by the
stockholders of the Corporation, increase the maximum number of shares of Common
Stock as to which Options may be granted under the Plan, increase the number  of
shares  subject to an Option, reduce the minimum Option exercise price described
in Section 6, extend the period during which Options may be granted or exercised
under the Plan or change the class of persons eligible to received Options under
the Plan. No  amendment of the  Plan shall materially  and adversely affect  any
right  of any holder of an Option with respect to any Option theretofore granted
without the written consent of the holder of such Option.
 
12. TERMINATION
 
     The Plan shall terminate upon the earlier to occur of (a) the adoption of a
resolution of the Board terminating the Plan,  (b) April 5, 2005, and (c)  April
4,  1996 if the Plan has not  been approved by the Corporation's stockholders at
the 1995 Annual Meeting.
 
13. EFFECTIVE DATE OF PLAN
 
     The Plan shall  become effective  as of April  5, 1995,  provided that  the
Corporation's  stockholders  shall have  approved the  Plan  at the  1995 Annual
Meeting.
 
14. 1992 NON-EMPLOYEE DIRECTORS' INCENTIVE PLAN
 
     If the  Corporation's stockholders  approve  the Plan  at the  1995  Annual
Meeting,  the Corporation's  1992 Non-Employee  Directors' Incentive  Plan shall
terminate and no additional options and  restricted stock awards may be  granted
thereunder,  provided that  all options  and restricted  stock awards previously
granted thereunder shall remain subject to the terms and conditions of the  1992
Non-Employee  Directors'  Incentive  Plan.  If  the  Plan  is  not  approved  by
stockholders at  the  1995  Annual Meeting,  the  1992  Non-Employee  Directors'
Incentive Plan shall remain in full force and effect.
 
                                      A-5

<PAGE>
                     DIRECTIONS TO THE SOMERSET HILLS HOTEL
 
                            200 LIBERTY CORNER ROAD
                            WARREN, NEW JERSEY 07059
                              PHONE # 908-647-6700
                               FAX # 908-647-8053
 
FROM CONNECTICUT, WESTCHESTER, AND NORTH SHORE LONG ISLAND
 
From George Washington Bridge, follow signs to I-80 West. Follow I-80 West until
I-287  South (  1/2 hour from  bridge). Exit  will read 'Somerville-Morristown.'
Follow I-287 South until the Mt. Airy Road exit. Exit on Mt. Airy Road and  make
a left onto Mt. Airy Road. Follow through 2 lights and at the third light make a
left. Hotel will be on the left. Total travel time is 50-55 minutes.
 
FROM SOUTH (WASHINGTON, D.C.)
 
Take New Jersey Turnpike North and exit at Exit 10. Get on I-287 North.** Follow
I-287    North    to    I-78   East.    Follow    I-78   East    to    Exit   33
(Bernardsville-Martinsville). At the end of the ramp make a left turn at  light.
Follow  through 2 lights and make a right  at the third light. Total travel time
from Exit 10 is 40 minutes.
 
FROM MIDTOWN MANHATTAN
 
Take the Lincoln Tunnel to  New Jersey Turnpike South.  Exit at Exit 14  (Newark
Airport)  and  follow  signs  to I-78  West.  ##  Follow I-78  West  to  Exit 33
(Bernardsville-Martinsville). At the  end of the  ramp make a  right and at  the
second light make a right to the hotel. Total travel time is 40 minutes.
 
FROM BROOKLYN OR SOUTH SHORE LONG ISLAND
 
Take  the Verazzano Bridge which will bring you to I-278 West. Follow I-278 West
to Route 440 South. Follow 440  South to the Outerbridge Crossing. Follow  signs
to I-287 North and follow Washington, D.C. directions starting with **.
 
FROM UPSTATE NEW YORK
 
From  the New York Thruway,  get on the Garden State  Parkway South. At Exit 142
(I-78) go west and follow Midtown Manhattan directions from ##.
 
FROM SOUTH NEW JERSEY (ATLANTIC CITY)
 
Take the Garden State Parkway to I-287  North. Follow I-287 North to I-78  East.
Follow  I-78 East to Exit 33 (Martinsville-Bernardsville). Make a left at end of
ramp and at the third light make a  right. The hotel will be on the left.  Total
travel time is 2 hours.

<PAGE>
                                   APPENDIX 1
                                   PROXY CARD

                              CELGENE CORPORATION

                                     PROXY


     The  undersigned  hereby appoints  Richard G. Wright and Sol J. Barer,  and
each of them, with power of substitution,  to represent and to vote on behalf of
the undersigned  all of the shares of Celgene  Corporation  (the  "Corporation")
which the  undersigned is entitled to vote at the Annual Meeting of Stockholders
to be held at the Somerset  Hills Hotel,  200 Liberty Corner Road,  Warren,  New
Jersey  on  Friday,  June  16,  1995,  at  1:00  p.m.,  local  time,  and at any
adjournment or  adjournments  thereof,  hereby  revoking all proxies  heretofore
given with  respect  to such  stock,  upon the  following  proposals  more fully
described in the notice of and proxy statement for the meeting (receipt of which
is hereby acknowledged).

<PAGE>



THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR (1), (2), and (3).

1.      ELECTION OF DIRECTORS

        FOR all nominees listed below (except as marked to the contrary)    [  ]

        WITHHOLD AUTHORITY to vote for all nominees listed below            [  ]

        Nominees:  Richard G. Wright, Sol J. Barer, Frank T. Cary,
        Richard C. E. Morgan, Walter L. Robb, Lee J. Schroeder

        (INSTRUCTION:                       To  withhold  authority  to vote for
                                            any individual  nominee,  write that
                                            nominee's name on the space provided
                                            below.)

        ------------------------------------------------------------------------

2.       PROPOSAL TO APPROVE THE  ADOPTION OF THE 1995  NON-EMPLOYEE  DIRECTOR'S
         INCENTIVE PLAN.

                    [  ] FOR    [ ] AGAINST    [  ] ABSTAIN

3.       PROPOSAL TO APPROVE  THE  APPOINTMENT  OF KPMG PEAT  MARWICK LLP AS THE
         INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS OF THE CORPORATION.

                    [  ] FOR    [ ] AGAINST    [  ] ABSTAIN
     
4.       In their discretion upon such other matters as may properly come before
         the meeting.

THIS PROXY, WHEN PROPERLY EXECUTED,  WILL BE VOTED IN THE MANNER DIRECTED HEREIN
BY THE  UNDERSIGNED  STOCKHOLDER.  IF NO DIRECTION  IS MADE,  THIS PROXY WILL BE
VOTED FOR PROPOSALS 1, 2, AND 3.

Please  sign  exactly  as name  appears  below.  When  shares  are held by joint
tenants,  both should sign. When signing as attorney,  executor,  administrator,
trustee, or guardian,  please give full title as such. If a corporation,  please
sign in full  corporate  name by President  or other  authorized  officer.  If a
partnership, please sign in partnership name by authorized person.



                                                   -----------------------------
                                                   Signature


                                                   -----------------------------
                                                   Signature if held jointly


                                                   Dated:_________________, 1995


              Please return in the enclosed postage-paid envelope.
I will [  ] will not [  ] attend the meeting.
THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS.




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