CELGENE CORP /DE/
DEF 14A, 1998-05-18
PHARMACEUTICAL PREPARATIONS
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                                  SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934


Filed by the Registrant [x]
Filed by a Party other than the Registrant [ ]
Check the appropriate box:
[ ] Preliminary Proxy Statement             [ ]Confidential, For Use of the Com-
                                                mission Only (as permitted by
                                                  Rule 14a-6(e)(2))
[X]Definitive Proxy Statement
[ ]Definitive Additional Materials
[ ]Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                               CELGENE CORPORATION
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)

- --------------------------------------------------------------------------------
     (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant

Payment of Filing Fee (Check the appropriate box): 
[X]No fee required.
[ ]Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
(1)Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------
(2) Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------
(3) Per unit price or other underlying value of transaction computed pursuant to
Exchange Act Rule 0-11 (set forth the amount on which the filing fee is
calculated and state how it was determined):

- --------------------------------------------------------------------------------
(4) Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------
(5) Total fee paid:

[ ] Fee paid previously with preliminary materials:
- --------------------------------------------------------------------------------
[ ] Check box if any part of the fee is offset as provided by Exchange Act Rule
0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously. Identify the previous filing by registration statement number, or
the form or schedule and the date of its filing.

(1) Amount previously paid:

- --------------------------------------------------------------------------------
(2) Form, Schedule or Registration Statement no.:

- --------------------------------------------------------------------------------
(3) Filing Party:

- --------------------------------------------------------------------------------
(4) Date Filed:


<PAGE>


                               CELGENE CORPORATION
                               7 Powder Horn Drive
                            Warren, New Jersey 07059
                                ----------------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                                ----------------

      The annual meeting of stockholders of CELGENE CORPORATION (the "Company")
will be held at the offices of Proskauer Rose LLP, 1585 Broadway, 26th floor,
New York, New York 10036 on June 23, 1998, at 1:00 p.m., local time, for the
following purposes:

            1. to elect nine directors;

            2. to approve an amendment to the Company's Certificate of
      Incorporation to increase the number of shares of the Company's authorized
      Common Stock, $.01 par value per share, from 20,000,000 shares to
      30,000,000 million shares;

            3. to approve the Celgene Corporation 1998 Long-Term Incentive Plan;

            4. to consider and act upon a proposal to confirm the appointment of
      KPMG Peat Marwick LLP as the independent certified public accountants of
      the Company for the current fiscal year; and

            5. to transact any such other business as may properly come before
      the meeting and at any adjournment thereof.

      The Board of Directors has fixed the close of business on May 15, 1998 as
the record date for determining stockholders entitled to notice of and to vote
at the meeting.

      A proxy and return envelope are enclosed for your convenience.

                                             By order of the Board of Directors
                                             JOHN W. JACKSON
                                             Chairman of the Board and
                                             Chief Executive Officer

      May 18, 1998


               -------------------------------------------------
                             YOUR VOTE IS IMPORTANT
                    Please mark, sign, and date the enclosed
                        proxy card and return it promptly
               in the enclosed self-addressed, stamped envelope.
               -------------------------------------------------

<PAGE>


                               CELGENE CORPORATION
                               7 Powder Horn Drive
                            Warren, New Jersey 07059

                                ----------------
                                 PROXY STATEMENT
                                ----------------

      This Proxy Statement is furnished to the stockholders of Celgene
Corporation, a Delaware corporation (the "Company"), in connection with the
solicitation of proxies by the Board of Directors for use at the annual meeting
of stockholders of the Company to be held on June 23, 1998, and at any
adjournment thereof. A copy of the notice of meeting accompanies this Proxy
Statement. It is anticipated that the mailing of this Proxy Statement will
commence on or about May 18, 1998.

      Only stockholders of record at the close of business on May 15, 1998, the
record date for the meeting, will be entitled to notice of and to vote at the
meeting. On the record date the Company had outstanding 16,145,255 shares of
common stock, par value $.01 per share (the "Common Stock"), which are the only
securities of the Company entitled to vote at the stockholders meeting, each
share being entitled to one vote.

      Stockholders who execute proxies may revoke them by giving written notice
to the Chief Executive Officer of the Company at any time before such proxies
are voted. Attendance at the meeting shall not have the effect of revoking a
proxy unless the stockholder so attending shall, in writing, so notify the
Secretary of the meeting at any time prior to the voting of the proxy.

      The Board of Directors does not know of any matter that is expected to be
presented for consideration at the meeting, other than the election of
directors, the amendment to the Company's Certificate of Incorporation to
increase the number of shares of the Company's authorized common stock, the
adoption of the Company's 1998 Long-Term Incentive Plan, and the confirmation of
the appointment of the independent certified public accountants of the Company
for the current fiscal year. However, if other matters properly come before the
meeting, the persons named in the accompanying proxy intend to vote thereon in
accordance with their judgment.

      The Company will bear the cost of the meeting and the cost of soliciting
proxies, including the cost of mailing the proxy material. In addition to
solicitation by mail, directors, officers, and regular employees of the Company
(who will not be specifically compensated for such services) may solicit proxies
by telephone or otherwise. Arrangements will be made with brokerage houses and
other custodians, nominees, and fiduciaries to forward proxies and proxy
material to their principals, and the Company will reimburse them for their
expenses. In addition, the Company has retained D.F. King & Co., Inc. of New
York, New York, a proxy solicitation organization, to assist in the solicitation
of proxies. D.F. King's fee is estimated to be $7,000, plus reasonable
out-of-pocket expenses.

      All proxies received pursuant to this solicitation will be voted except as
to matters where authority to vote is specifically withheld and, where a choice
is specified as to the proposal, they will be voted in accordance with such
specification. If no instructions are given, the persons named in the proxy
solicited by the Board of Directors of the Company intend to vote FOR the
nominees for election as directors of the Company listed herein, FOR the
amendment of the Company's Certificate of Incorporation to increase the number
of shares of the Company's authorized common stock, FOR the Celgene Corporation
1998 Long-term Incentive Plan, and FOR the confirmation of the appointment of
KPMG Peat Marwick LLP as independent certified public accountants of the Company
for the current fiscal year.
<PAGE>


      Abstentions are counted in tabulations of the votes cast on proposals
presented to stockholders, whereas broker non-votes are not counted for purposes
of determining whether a proposal has been approved. Abstentions and broker
non-votes will have no effect on the election of directors, which is by
plurality vote, but abstentions will, in effect, be votes against the adoption
of the Company's 1998 Long-Term Incentive Plan and the ratification of the
selection of independent public accountants, as these items require the
affirmative vote of the shares present and eligible to vote on such matters.
Since approval of the proposed amendment to the Company's Certificate of
Incorporation requires the affirmative vote of a majority of the outstanding
shares, both abstentions and broker non-votes will, in effect, be votes against
such matter.


                                       2
<PAGE>

                                  PROPOSAL ONE
                              ELECTION OF DIRECTORS

     At the meeting, nine Directors are to be elected, each to hold office
(subject to the Company's By-Laws) until the next annual meeting and until his
successor has been elected and qualified. Pursuant to the Company's By-Laws,
the Board has fixed the number of Directors at nine. Each nominee has consented
to being named as a nominee in this Proxy Statement and to serve if elected. If
any nominee listed in the table below should become unavailable for any reason,
which management does not anticipate, the proxy will be voted for any
substitute nominee or nominees who may be selected by the management prior to
or at the meeting, or, if no substitute is selected by the management prior to
or at the meeting, for a motion to reduce the membership of the Board to the
number of nominees available. Directors will be elected by a plurality of the
votes cast. There are no family relationships between any of the directors and
executive officers of the Company. The information concerning the nominees and
their security holdings has been furnished by them to the Company.


<TABLE>
<CAPTION>
                  Name                     Age                          Position
- ---------------------------------------   -----   ---------------------------------------------------
<S>                                       <C>     <C>
John W. Jackson .......................   53      Chairman of the Board and Chief Executive Officer
Sol J. Barer, Ph.D. ...................   50      President, Chief Operating Officer, and a Director
Jack L. Bowman ........................   65      Director
Frank T. Cary .........................   77      Director
Arthur Hull Hayes, Jr., M.D. ..........   65      Director
Gilla Kaplan, Ph.D. ...................   50      Director
Richard C.E. Morgan ...................   53      Director
Walter L. Robb, Ph.D. .................   70      Director
Lee J. Schroeder ......................   69      Director
</TABLE>

- ----------
     John W. Jackson has been Chairman of the Board and Chief Executive Officer
of the Company since January 1996. Mr. Jackson was founder and President of
Gemini Medical, a consulting firm which specialized in services and investment
advice to start-up medical device and biotechnology companies, from February
1991 to January 1996. Previously, Mr. Jackson had been President of the
worldwide Medical Device Division of American Cyanamid, a major pharmaceutical
company, from February 1986 to January 1991 and served in various international
positions, including Vice President-International for American Cyanamid from
1978 to 1986. Mr. Jackson served in several human health marketing positions at
Merck & Company, a major pharmaceutical company, from 1971 to 1978.

     Sol J. Barer has been President of the Company since October 1993 and
Chief Operating Officer and a director of the Company since March 1994. Dr.
Barer was Senior Vice President--Science and Technology and Vice
President/General Manager--Chiral Products of the Company from October 1990 to
October 1993 and Vice President--Technology of the Company from September 1987
to October 1990. Dr. Barer received a Ph.D. in organic and physical chemistry
from Rutgers University.

     Jack L. Bowman, a director of the Company since April 1998, served as
Company Group Chairman of Johnson & Johnson from 1987 to 1994. From 1983 to
1987 Mr. Bowman served as Executive Vice President of American Cyanamid. Mr.
Bowman is also a director of NeoRx Corporation, Cell Therapeutics, Inc., CytRx
Corporation, Cellegy Pharmaceuticals and Targeted Genetics.

     Frank T. Cary has been Chairman of the Executive Committee of the Board of
Directors of the Company since July 1990 and has been a director of the Company
since 1987. From 1973 to 1981, Mr. Cary was Chairman of the Board and Chief
Executive Officer of International Business Machines Corporation. Mr. Cary also
is a director


                                       3
<PAGE>

of Cygnus Therapeutic Systems Inc., ICOS Corporation, Lincare Inc., SPS
Transaction Services, Inc., Lexmark International Inc., SEER Technologies,
Inc., Vion Pharmaceuticals Inc. and Teltrend, Inc.

     Arthur Hull Hayes, Jr., a director of the Company since 1995, has been
President and chief operating officer of MediScience Associates, Inc., a
consulting organization that works with pharmaceutical firms, biomedical
companies and foreign governments, since July 1991. Dr. Hayes has also been a
partner in Issue Sphere, a public affairs firm that focuses on health science
issues, since November 1995, as well as a professor in medicine, pharmacology
and family and community medicine at New York Medical College and clinical
professor of medicine and pharmacology at the Pennsylvania State University
College of Medicine. From 1986 to 1990, Dr. Hayes was President and Chief
Executive Officer of E.M. Pharmaceuticals, a unit of E. Merck AG and from 1981
to 1983 was Commissioner of the U.S. Food and Drug Administration. Dr. Hayes
also is a director of Myriad Genetics, Inc., NaPro BioTherapeutics, Inc. and
Premier Research Worldwide.

     Gilla Kaplan, Ph.D, a director of the Company since April 1998, is an
immunologist in the Laboratory of Cellular Physiology and Immunology at The
Rockefeller University in New York where she was appointed Assistant Professor
in 1985 and Associate Professor in 1990. Dr. Kaplan is a member of numerous
professional societies and has been the organizer of several major symposia on
tuberculosis. Dr. Kaplan has served as an advisor to the Global Program for
Vaccines and Immunization of the World Health Organization, has participated in
several NIH peer review panels, is on the Editorial Board of Microbial Drug
Resistances, since 1994, and Tubercle and Lung Disease, since 1997. Dr. Kaplan
is the author of more than 100 scientific publications and has received
international recognition for her work. In 1995, she gave the Special Honorary
Lecture at the American Society for Microbiology and in 1997 was appointed a
Fellow of the American Academy of Microbiology.

     Richard C.E. Morgan, a director of the Company since 1987 has been the
Managing Member of Amphion Partners LLC (formerly Wolfensohn Partners, L.P.),
since 1986. Between January 1996 and January 1998, Mr. Morgan was a partner of
Jackson Hole Management Company, Inc. Mr. Morgan also is Chairman of the Board
of Directors and Chief Executive Officer of AXCESS, Inc.; a director of SEQUUS
Pharmaceuticals, Inc.; Chairman of the Board of Directors of Quidel Corp.; a
director of ChromoVision Medical Systems, Inc.; and a director of Indigo, N.V.

     Walter L. Robb, a director of the Company since 1992, has been a private
consultant and President of Vantage Management Inc., a consulting and investor
services company, since January 1993. Mr. Robb was Senior Vice President for
Corporate Research and Development of General Electric Company, and a member of
its Corporate Executive Council from 1986 to December 1992. Mr. Robb also is
Chairman of the Board of Directors of Neopath, Inc. and a director of Marquette
Electronics, Inc., Cree Research Inc., and Mechanical Technology, Inc.

     Lee J. Schroeder, a director of the Company since 1995, has been President
of Lee Schroeder & Associates, Inc., pharmaceutical business consultants, since
1985. Mr. Schroeder was President of Fox Meyer Lincoln from 1983 to 1985, and
was an Executive Vice President of Sandoz, Inc. from 1981 to 1983. Mr.
Schroeder also is a director of Harris Technology Group, Inc., Bryan Memorial
Hospital, MGI Pharmaceutical, Inc., Ascent Pediatrics, Inc., and Interneuron
Pharmaceuticals, Inc.

Executive Officers Who Are Not Directors

     Robert C. Butler, 67, has been Chief Financial Officer of the Company
since July 1996. Mr. Butler plans to retire in July 1998. From 1988 to 1995,
Mr. Butler served as Senior Vice President and Chief Financial Officer of
International Paper Co., a manufacturer of paper, wood, and allied products.
From 1979 to 1987, Mr. Butler served as Group Executive Vice President of the
National Broadcasting Company. Mr. Butler is also a member of the Board of
Directors of Carter Holt Harvey Ltd., a major New Zealand forest products
company.


                                        4
<PAGE>

Security Ownership of Certain Beneficial Owners and Management

     The table below sets forth the beneficial ownership of the Common Stock as
of April 27, 1998 (i) by each director, (ii) by each of the named executive
officers (iii) by all directors and executive officers of the Company as a
group, and (iv) by all persons known by the Board of Directors to be beneficial
owners of more than five percent of the outstanding shares of Common Stock.

<TABLE>
<CAPTION>
                                                       Amount and
                                                        Nature of
                                                       Beneficial      Percent
                       Name                             Ownership      of Class
- -------------------------------------------------   ---------------   ---------
<S>                                                   <C>                 <C> 
John W. Jackson .................................     272,400(1)(2)       1.7%
Sol J. Barer, Ph.D. .............................     209,928(2)          1.3%
Jack L. Bowman ..................................          --               *
Robert C. Butler ................................      17,500(1)            *
Frank T. Cary ...................................     106,000(1)            *
Arthur Hull Hayes, Jr., M.D. ....................      30,000(1)            *
Gilla Kaplan ....................................          --               *
Richard C.E. Morgan .............................     330,055(1)(3)       2.1%
Walter L. Robb, Ph.D. ...........................      92,000(1)            *
Lee J. Schroeder ................................      41,000(1)            *
All directors and current executive officers of
 the Company as a group (eight persons) .........   1,098,883(4)          6.9%
Donald P. Moriarty and
 William P. Scully(5) ...........................   1,355,000             8.5%
 c/o McGrath, Doyle & Phair
 150 Broadway
 New York, New York 10038
Frontier Capital Management
 Company, Inc.(6) ...............................     806,960(6)          5.0%
 99 Summer Street Boston, MA 02110 ..............
Chancellor LGT Asset Management, Inc.,
 Chancellor LGT Trust Company and LGT Asset
 Management, Inc. as a group(7) .................   1,067,700(8)          6.7%
 1166 Avenue of the Americas
 New York, New York 10036
</TABLE>

- ----------
* Less than one percent (1%).

(1)   Includes shares of Common Stock which the directors and executive officers
      have the right to acquire through the exercise of options within 60 days
      of April 27, 1998, as follows: John W. Jackson--250,000; Sol J. Barer--
      209,913; Robert C. Butler--12,500; Frank T. Cary--76,000; Arthur Hull
      Hayes, Jr.--30,000; Richard C.E. Morgan--71,000 shares; Walter L.
      Robb--49,000, and Lee J. Schroeder--41,000. Does not include shares of
      Common Stock which the directors and executive officers had the right to
      acquire through the exercise of options not exercisable within 60 days of
      April 27, 1998, as follows: John W. Jackson--100,000; Sol J.
      Barer--74,167; Robert C. Butler--37,500; Frank T. Cary--5,000; Arthur Hull
      Hayes, Jr.--10,000; Richard C.E. Morgan--5,000; Walter L. Robb--5,000, and
      Lee J. Schroeder--5,000.


                                       5
<PAGE>

(2)   Includes with respect to Mr. Jackson 400 shares owned by the son of Mr.
      Jackson, as to which shares Mr. Jackson disclaims beneficial ownership;
      includes with respect to Dr. Barer 15 shares owned by the daughter of Dr.
      Barer, as to which shares Dr. Barer disclaims beneficial ownership.

(3)   Includes 252,055 shares of Common Stock owned by Amphion Ventures, L.P. of
      which Amphion Partners, LLC is the general partner. Mr. Morgan is a
      managing member of Amphion Ventures, LLC. Mr. Morgan's indirect pecuniary
      interest in these shares of Common Stock, within the meaning of Rule
      16a-1(a)(2)(ii)(B) under the Securities Exchange Act of 1934, is
      significantly less than the amount disclosed. Mr. Morgan otherwise
      disclaims beneficial ownership of such shares of Common Stock owned by
      Amphion Ventures, L.P.

(4)   Includes or excludes, as the case may be, shares of Common Stock as
      indicated in the preceding footnotes.

(5)   Information regarding Donald P. Moriarty and William P. Scully was
      obtained from a Schedule 13D, as amended, filed by them with the
      Securities and Exchange Commission. Such Schedule 13D states that Messrs.
      Moriarty and Scully are deemed to be the beneficial owners of and to have
      shared dispositive power over all such shares of Common Stock, and that
      such shares are held by Mr. Moriarty, Mr. Scully, their family members,
      and Twin Oaks Partners, a partnership in which Messrs. Moriarty and Scully
      are general partners.

(6)   Information regarding Frontier Capital Management Company, Inc. was
      obtained from a Schedule 13G, filed by it with the Securities and Exchange
      Commission. Such Schedule 13G states that Frontier Capital Management
      Company, Inc. is the beneficial owner of and has the sole dispositive
      power over all such shares of Common Stock.


(7)   Information regarding Chancellor LGT Asset Management, Inc., Chancellor
      LGT Trust Company and LGT Asset Management, Inc. (the "Group") was
      obtained from a Schedule 13G, filed by them with the Securities and
      Exchange Commission. Such Schedule 13G states that the Group filed as a
      group and as such it is the beneficial owner of and has sole dispositive
      power over all such shares of Common Stock.


(8)   Includes warrants to purchase 519,231 shares of Common Stock.


Director Compensation

      Directors do not receive salaries or cash fees for serving as directors
nor do they receive any cash compensation for serving on committees; however,
all members of the Board of Directors who are not employees of the Company
("Non-Employee Directors") are reimbursed for their expenses for each meeting
attended and are eligible to receive stock options pursuant to the 1995
Non-Employee Directors' Plan (the "1995 Directors' Plan").

      The 1995 Directors' Plan was adopted by the Board of Directors on April 5,
1995, and approved by the Company's stockholders at the 1995 Annual Meeting of
Stockholders. The 1995 Directors' Plan provides for the granting to Non-Employee
Directors of non-qualified options to purchase an aggregate of not more than
250,000 shares (subject to adjustment in certain circumstances) of Common Stock.

      Under the 1995 Directors' Plan, each Non-Employee Director as of April 5,
1995 was granted a non-qualified option to purchase 20,000 shares of Common
Stock, and each new Non-Employee Director upon the date of his election or
appointment will be granted a non-qualified option to purchase 20,000 shares of
Common Stock. These initial options vest in four equal annual installments
commencing on the first anniversary of the date of grant, assuming the
Non-Employee Director remains a director.

      Upon the date of each Annual Meeting of Stockholders, each Non-Employee
Director is granted a non-qualified option to purchase 10,000 shares of Common
Stock (or a pro rata portion thereof if the director did not serve the entire
year since the date of the last annual meeting). These options vest in full on
the date of the first Annual Meeting


                                       6
<PAGE>

of Stockholders held following the date of the grant, assuming the Non-Employer
Director is a director on that date.

      All options granted pursuant to the 1995 Directors' Plan will expire no
later than 10 years from the date of grant and no options may be granted after
June 16, 2005. If a Non-Employee Director terminates his or her service on the
Board of Directors for any reason, options which were exercisable on the date of
termination and which have not expired may be exercised at any time until the
date of expiration of such options. In addition, if there is a change of control
and within two years thereafter a director is removed without cause (as defined)
or is not nominated for election by the Company's stockholders, all unvested
portions of a stock option will automatically vest.

      In 1997, pursuant to the 1995 Directors' Plan, each of Messrs. Cary,
Hayes, Morgan, Robb and Schroeder received an option to purchase 10,000 shares
of Common Stock at an exercise price of $7.125 per share, the fair market value
of the stock on the date of grant.

Board Committees and Membership

      The Company has an Executive Committee of the Board of Directors, whose
current members are Frank T. Cary, Chairman, Sol J. Barer, John W. Jackson and
Richard C. E. Morgan. The Executive Committee held one meeting in 1997. The
Executive Committee has and may exercise all of the powers and authority of the
full Board of Directors of the Company, subject to certain exceptions.

      The Company has an Audit Committee of the Board of Directors, consisting
entirely of outside directors, the current members of which are Walter L. Robb,
Chairman, Frank T. Cary, Richard C. E. Morgan, and Lee J. Schroeder. The Audit
Committee held one meeting in 1997. The Board of Directors has delegated to the
Audit Committee the following duties: reviewing with the independent auditors
the plans and results of the audit engagement; reviewing the adequacy, scope,
and results of the internal accounting controls and procedures; reviewing the
degree of independence of the auditors; reviewing the auditors' fees; and
recommending the engagement of auditors to the full Board of Directors.

      The Company has a Management Compensation and Development Committee (the
"Compensation Committee") of the Board of Directors, whose current members are
Richard C.E. Morgan, Chairman, Frank T. Cary, Walter L. Robb, and Lee J.
Schroeder. The Compensation Committee held two meetings in 1997. The
Compensation Committee has (i) the full power and authority to interpret the
provisions and supervise the administration of the Company's 1986 Stock Option
Plan, 1992 Long-Term Incentive Plan and, if approved at the Annual Meeting, the
1998 Long-Term Incentive Plan and to grant options outside of these plans and
(ii) the authority to review all matters relating to the personnel of the
Company.

      The Company does not have a nominating committee. The Board of Directors
held eight meetings during 1997. During 1997, all of the directors attended more
than 75% of the aggregate of (i) the total number of meetings of the Board of
Directors and (ii) the total number of meetings of all committees of the Board
on which such director served.

Compliance with Section 16(a) of the Securities Exchange Act of 1934

      Under the securities laws of the United States, the Company's directors,
executive officers, and any persons holding more than 10 percent of the Common
Stock are required to report their ownership of Common Stock and any changes in
that ownership, on a timely basis, to the Securities and Exchange Commission.
Based on material provided to the Company, all such required reports were filed
on a timely basis in 1997.


                                       7
<PAGE>

                 EXECUTIVE COMPENSATION AND OTHER INFORMATION


Summary of Cash and Certain Other Compensation

      The following table sets forth information about the compensation paid, or
payable, by the Company for services rendered in all capacities to the Chief
Executive Officer of the Company and each of the most highly paid executive
officers of the Company who earned more than $100,000, for each of the last
three fiscal years in which such officers were executive officers for all or
part of the year.


<TABLE>
<CAPTION>
                                                       Annual                                      Long Term                        
                                                    Compensation                                 Compensation                       
                             -----------------------------------------------------------  ---------------------------               
                                                                             Other          Restricted    Securities     All Other  
          Name and                                                          Annual             Stock      Underlying      Compen-   
     Principal Position       Year     Salary ($)        Bonus ($)     Compensation ($)    Award(s) ($)    Options #     sation ($) 
- ---------------------------- ------   -----------       ----------    ------------------  -------------- ------------ --------------
<S>                           <C>      <C>               <C>               <C>                    <C>      <C>            <C>      
John W. Jackson. ...........  1997     270,000           97,200            9,500(3)               0              0        13,390(4)
 Chairman and                 1996     243,429(1)       105,625(2)         4,750(3)               0        250,000             0   
 Chief Executive Officer                                                                                                           
Sol J. Barer, Ph.D. ........  1997     232,500           63,647            9,500(3)               0              0             0   
 President and Chief          1996     216,667           50,000            4,750(3)               0         72,500             0   
 Operating Officer            1995     200,000                0                0                  0         54,080             0   
                                                                                               
</TABLE>

- ----------

(1)   Mr. Jackson commenced his employment with the Company on January 11, 1996.

(2)   Mr. Jackson's bonus consisted of $50,000 in cash and 5,000 shares of
      unrestricted stock, valued at $55,625 on the date of grant.

(3)   Reflects matching contributions under the Company's 401(k) plan.

(4)   Reflects life insurance premiums for a life insurance policy for Mr.
      Jackson.

Employment Agreements and Termination of Employment Arrangements

      John W. Jackson and Sol J. Barer (each an "Executive") are employed
pursuant to substantially similar employment agreements (the "Employment
Agreements") providing for their continued employment until September 30, 2000
(the period during which the Executive is employed is referred to as the
"Employment Period"). The Employment Period shall be automatically renewed for
successive one-year terms unless the Company or the Executive gives written
notice to the other at least one year prior to the expiration of the Employment
Period. The Employment Agreements provide Messrs. Jackson and Barer with a base
salary (which may be increased by the Board of Directors, or a committee
thereof) of $270,000 and $235,000, respectively, per annum. In addition, each of
the Employment Agreements provides for an annual bonus in such amount as may be
determined by the Board of Directors, or a committee thereof. The Employment
Agreements also provide that Messrs. Jackson and Barer are entitled to continue
to participate in all group health and insurance programs and all other fringe
benefit or retirement plans which are generally available to the Company's
employees. Each of the Employment Agreements provides that if the Executive is
terminated by the Company without cause, he shall be entitled to receive a
lump-sum payment in an amount equal to the greater of (A) twelve months salary
at the rate being paid on the date of such termination or (B) salary at such
rate for the unexpired term of the Employment Agreement. Each Employment
Agreement also provides that if Executive is terminated without cause or if
Executive terminates his employment within 30 days of having actual knowledge of
the occurrence of any of the following events: (i) Executive not maintaining his
position with the Company as Chief Executive Officer (in the case of Mr.
Jackson) and Chief Operating Officer (in the case of Mr. Barer), (ii) a
significant change in the duties normally attached to such Executive's position,


                                       8
<PAGE>

(iii) a good faith determination by such Executive that, as a result of a change
in control, such Executive is unable to carry out the duties of such position
and (iv) a breach by the Company of any material term of such Executive's
Employment Agreement, the Executive shall be paid in a lump-sum an amount of
cash equal to 2.99 times Executive's "base amount," as defined in Section
280G(b)(3) of the Internal Revenue Code of 1986, as amended (the "Code").

      If during the two-year period following a change in control (as defined in
the Company's 1992 Long-Term Incentive Plan) of the Company, (i) there is a
change in an employee's title or a significant change in the nature or scope of
his employment or duties and such person terminates his employment within 90
days following such change or (ii) an employee's employment by the Company is
terminated without cause (as defined), then all of the options held by such
employee then outstanding will become immediately and fully exercisable, and all
restrictions applicable to restricted stock automatically will terminate.

Stock Options

      No stock options or stock appreciation rights ("SARs") were granted in
fiscal 1997 to John W. Jackson or Sol J. Barer.

      The following table sets forth information for each of the named executive
officers with respect to the value of options exercised during the year ended
December 31, 1997 and the value of outstanding and unexercised options held as
of December 31, 1997. There were no SARs exercised during 1997 and none were
outstanding as of December 31, 1997.

                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR-END OPTION VALUES

<TABLE>
<CAPTION>
                                                                           Number of
                                                                     Securities Underlying         Value of Unexercised
                                                                      Unexercised Options          In-the-Money Options
                                 Shares                              at December 31, 1997        at December 31, 1997(1)
                                Acquired                         ----------------------------- ----------------------------
           Name             on Exercise ($)   Value Realized ($)  Exercisable   Unexercisable   Exercisable   Unexercisable
- -------------------------- ----------------- ------------------- ------------- --------------- ------------- --------------
<S>                               <C>                <C>           <C>             <C>            <C>              <C>
John W. Jackson. .........        --                 --            166,667         83,333         $      0         $0
Sol J. Barer .............        --                 --            190,986         48,334         $160,937         $0
</TABLE>

- ----------

(1)   Represents the difference between the closing market price of the Common
      Stock as reported by Nasdaq on December 31, 1997 of $8.438 per share and
      the exercise price per share of in-the-money options multiplied by the
      number of shares underlying the in-the-money options.

Compensation Committee Report

      The Compensation Committee determines the Company's executive compensation
policies. The Compensation Committee determines the compensation of the
Company's executive officers and approves and oversees the administration of
incentive compensation programs for all employees including executive officers.
The Compensation Committee is composed solely of outside directors.

Executive Compensation Policies and Programs

      The Company's executive compensation program is part of a company-wide
program covering all employees. The program's goals are to attract, retain, and
motivate employees, and it utilizes incentives such that employees and
stockholders share the same risks. The compensation program is designed to link
compensation to performance.

      A portion of each employee's compensation relates to the grant of stock
options, and such grants are based on the successful attainment of strategic
corporate, business unit, and individual goals. As the Company has not


                                       9
<PAGE>

as yet attained significant commercial revenues, goals are set which relate to
the successful attainment of strategic events. Any long-term value to be
derived from such grants will be consistent with stockholder gains.

      Executive and employee compensation includes salary, employment-related
benefits, and long-term incentive compensation:

      Salary. Salaries are set competitively relative to the biotechnology and
pharmaceutical industries--industries with which the Company competes for its
highly skilled personnel. Individual experience and performance is considered
when setting salaries within the range for each position. Annual reviews are
held and adjustments are made based on attainment of individual goals.

      Benefits. All employees are eligible for similar benefits, such as health,
disability, and life insurance.

      Long-Term Incentive Compensation. An incentive compensation program is
established annually. The purpose of this program is to provide financial
incentives to executives and employees to achieve annual corporate, business
unit, and individual goals. The incentive program also aligns executive and
employee interests with those of stockholders by using grants of stock options.
Such grants vest over time thereby encouraging continued employment with the
Company. The size of grants is tied to comparative biotechnology industry
practices. To determine such comparative data, the Company relies on outside
compensation consultants, the Company's auditors, and third party industry
surveys.

      Under the Company's 1997 incentive program, it was agreed, subject to the
achievement of certain goals in 1997 by the Company, that the Company would
grant at a future date options to purchase shares of common stock. A similar
incentive program has been designed for 1998 based on attainment of corporate,
business unit, and individual goals. The program is open to all regular
full-time employees, other than the executive officers of the Company.

      Chief Executive Officer Compensation. Pursuant to Mr. Jackson's contract
with the Company entered into on September 30, 1997, Mr. Jackson received base
salary of $270,000 for 1997. Mr. Jackson also received a bonus of $97,200 for
1997. Factors considered in determining Mr. Jackson's bonus included the
successful attainment of several important milestones in the development of the
Company's products, as well comparisons to total compensation packages of chief
executive officers at corporations within the Company's industry that are of
comparable size.

                                         Members of the Compensation Committee
                                         Richard C.E. Morgan, Chairman
                                         Frank T. Cary
                                         Walter L. Robb
                                         Lee J. Schroeder

Compensation Committee Interlocks and Insider Participation

      The current members of the Compensation Committee are Richard C. E.
Morgan, Chairman, Frank T. Cary, Walter L. Robb, and Lee J. Schroeder. Each is
an outside director of the Company.


                                       10
<PAGE>

Performance Graph

      The following graph shows changes over the past five years in the value of
$100 invested in: 1) the Company's Common Stock; 2) the Standard & Poor's 500
Index; and 3) the NASDAQ Pharmaceutical Index.

      The graph shows the value of $100 invested on December 31, 1992 in the
Company's Common Stock or in one of the indexes, as applicable, including
reinvestment of dividends, at December 31 for each of 1993-1997.


                COMPARISON OF FIVE YEAR CUMULATIVE TOTAL RETURN*
                  AMONG CELGENE CORPORATION, THE S&P 500 INDEX
                       AND THE NASDAQ PHARMACEUTICAL INDEX

<TABLE>
<CAPTION>
                                   12/92   12/93   12/94   12/95   12/96   12/97
<S>                                  <C>      <C>     <C>    <C>      <C>     <C>
Celgene Corporation                  100      53      43     102      85      64
Standard & Poor's 500 Index          100     110     112     153     189     252
Nasdaq Pharmaceutical Index          100      89      67     123     123     127
</TABLE>

* $100 INVESTED ON 12/31/92 IN STOCK OR INDEX -
  INCLUDING REINVESTMENT OF DIVIDENDS.
  FISCAL YEAR ENDING DECEMBER 31.


                                       11
<PAGE>

                                  PROPOSAL TWO
                           AMENDMENT OF THE COMPANY'S
                          CERTIFICATE OF INCORPORATION
           TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF COMMON STOCK

     The Board of Directors has approved, and recommends that the Company's
stockholders approve, an amendment (the "Amendment") to the Company's
Certificate of Incorporation that would increase the number of shares of the
Company's authorized Common Stock, par value $.01 per share ("Common Stock")
from 20,000,000 to 30,000,000. As of April 27, 1998 there were 16,031,450
shares of Common Stock outstanding and an aggregate 3,524,974 shares of Common
Stock were issuable upon exercise of outstanding options under the Company's
1992 Long-Term Incentive Plan, its 1995 Non-Employee Directors' Plan and other
options and warrants. Accordingly, there are only 443,576 shares of authorized
Common Stock that are not outstanding or issuable as described above.

     The Company has no present intention to issue the additional authorized
shares in any presently contemplated transaction, including any stock split,
stock dividend, public or private offering, acquisition or exchange for other
securities. However, the Board of Directors believes that the increased number
of authorized shares of common stock will improve the Company's flexibility.
The Board of Directors will determine whether, when and on what terms the
issuance of shares of Common Stock may be warranted in connection with any
future actions. No further action nor authorization by the Company's
stockholders would be necessary prior to issuance of the Common Stock, except
as may be required for a particular transaction by the Company's Certificate of
Incorporation, by applicable law or regulatory agencies or by the rules of the
Nasdaq Stock Market or of any stock exchange on which the Company's Common
Stock may then be listed. Requiring the stockholders to meet and approve each
separate issuance of additional Common Stock would be time-consuming and
costly. Moreover, if stockholder authorization of additional Common Stock were
postponed until a specific need arose, the delay could, in some instances,
deprive the Company and its stockholders of opportunities otherwise available.

     While not intended as an anti-takeover provision, the increase in
authorized shares by the proposed amendment could under some circumstances (i)
enable existing directors and officers of the Company to increase their
beneficial ownership of the Company in response to a takeover attempt by
another person by entering into transactions resulting in the issuance of
authorized shares by the Company to existing directors and officers and/or (ii)
dilute the beneficial ownership of the person making the takeover attempt by
issuing shares to another person who might assist the Board of Directors in
opposing the takeover if the Board of Directors determines that the takeover is
not in the best interests of the Company and its stockholders.

     The affirmative vote of a majority of the outstanding shares of Common
Stock entitled to vote at the annual meeting is required to approve the
foregoing amendment to the Company's Certificate of Incorporation. The Board
recommends that the stockholders vote their shares for the Amendment.


                                       12
<PAGE>

                                 PROPOSAL THREE
                CELGENE CORPORATION 1998 LONG-TERM INCENTIVE PLAN

     The stockholders of the Company are asked to approve the adoption of the
Company's 1998 Long-Term Incentive Plan (the "Plan"). The Board approved the
establishment of the Plan pursuant to unanimous written consent on May 6, 1998,
subject to approval of stockholders. The affirmative vote of the holders of at
least a majority of the outstanding shares of Common Stock present and entitled
to vote at the annual meeting is required to approve the adoption of the Plan.
The Board recommends that the stockholders vote their shares for the proposal
to approve the adoption of the Plan.

     The Company presently may grant (i) stock options, (ii) stock appreciation
rights, (iii) restricted stock, and other performance based awards to employees
and officers of the Company pursuant to the Company's 1992 Long-Term Incentive
Plan (the "1992 Plan"). As of March 31, 1998, fewer than 55,000 shares out of
the aggregate 1,400,000 shares of Common Stock authorized for grant under the
1992 Plan remain available for future grants.

Summary of the Plan

     Background; Purpose; Eligibility.  The following is a brief summary of the
principal provisions of the Plan. This summary does not purport to be complete
and is qualified in its entirety by reference to the text of the Plan set forth
as Exhibit A hereto. The purpose of the Plan is to enhance the profitability
and value of the Company and its affiliates for the benefit of their
stockholders by enabling the Company to offer selected management and other
employees of the Company and its affiliates, stock based incentives and other
equity interests in the Company, thereby creating a means to raise the level of
stock ownership by employees in order to attract, retain and reward such
employees and strengthen the mutuality of interests between employees and the
Company's stockholders.

     Administration.  The Plan is administered by a Management Compensation and
Development Committee or such other committee or subcommittee appointed from
time to time by the Board, which is intended to consist of two or more
non-employee directors, each of whom will be, to the extent required by Rule
16b-3 ("Rule 16b-3") under the Securities Exchange Act of 1934 (the "Exchange
Act") and Section 162(m) of the Code, a non-employee director as defined in
Rule 16b-3 and an outside director as defined under Section 162(m) of the Code
(the "Committee"). If for any reason the appointed Committee does not meet the
requirements of Rule 16b-3 of the Exchange Act or Section 162(m) of the Code,
the validity of the awards, grants, interpretation or other actions of the
Committee will not be affected. The Committee has the full authority to select
those individuals eligible to receive awards and the amount and type of awards.
Terms and conditions of awards will be set forth in written grant agreements,
the terms of which will be consistent with the terms of the Plan. Awards under
the Plan may not be made on or after the tenth anniversary of the date of its
adoption, but awards granted prior to such date may extend beyond that date.

     Types of Awards.  The Plan provides for the grant of any or all of the
following types of awards: (i) stock options, including incentive stock options
and non-qualified stock options; (ii) stock appreciation rights, in tandem with
stock options or freestanding; (iii) restricted stock; and (iv)
performance-based awards.

     Stock Options.  Options may be in the form of incentive stock options or
non-qualified stock options. The Committee will, with regard to each stock
option, determine the number of shares subject to the option, the term of the
option (which shall not exceed ten years, provided, however, that the term of
an incentive stock option granted to a 10% stockholder of the Company shall not
exceed five years), the exercise price per share of stock subject to the
option, the vesting schedule (if any), and the other material terms of the
option. No stock option may have an exercise price less than the fair market
value (as defined in the Plan) of the Common Stock at the time of grant (or, in
the case of an incentive stock option granted to a 10% stockholder of the
Company, 110% of the fair market value of the Common Stock).


                                       13
<PAGE>

     The exercise price upon exercise may be paid in cash, shares of Common
Stock owned by the recipient for at least six months and for which the
recipient has good title free and clear of any liens or encumbrances or, if the
Common Stock is traded on a national securities exchange, through the delivery
of irrevocable instructions to a broker to deliver to the Company an amount
equal to the exercise price. The Committee may also provide, at the time of
grant, that the shares to be issued upon the exercise of a stock option be in
the form of restricted stock or may, in the stock option agreement, reserve a
right to do so after the time of grant.

     Stock Appreciation Rights ("SARs").  The Committee may grant SARs either
with a stock option ("Tandem SARs") or independent of a stock option
("Non-Tandem SARs"). An SAR is a right to receive a payment either in cash or
Common Stock as the Committee may determine, equal in value to the excess of
the fair market value of a share of Common Stock on the date of exercise over
the reference price per share of Common Stock established in connection with
the grant of the SAR. The reference price per share covered by an SAR will be
the per share exercise price of the related option in the case of a Tandem SAR
and will be the per share fair market value of common stock on the date of the
grant in the case of a Non-Tandem SAR. The Committee may also grant "limited
SARs," either as Tandem SARs or Non-Tandem SARs, which may become exercisable
only upon the occurrence of a Change in Control (as defined in the Plan) or
such other event as the Committee may, in its sole discretion, designate at the
time of grant or thereafter.

     Restricted Stock.  The Committee may award shares of restricted stock. Upon
the award of restricted stock, the recipient has all rights of a stockholder
with respect to the shares, including, without limitation, the right to receive
dividends, the right to vote such shares and, subject to and conditioned upon
the full vesting of the shares of restricted stock, the right to tender such
shares. Unless otherwise determined by the Committee at grant, the payment of
dividends, if any, shall be deferred until the date that the relevant share of
restricted stock vests.

     Recipients of restricted stock are required to enter into a restricted
stock award agreement with the Company which states that the restrictions to
which the shares are subject and the criteria or date or dates on which such
restrictions will lapse. Within these limits, based on service, attainment of
performance goals, and such other factors as the Committee may determine in its
sole discretion, or a combination thereof, the Committee may provide for the
lapse of such restrictions in installments in whole or in part or may
accelerate or waive such restrictions at any time. If the lapse of the relevant
restriction is based on the attainment of performance goals, the Committee
shall establish the goals, formulae or standards and the applicable vesting
percentage for the restricted stock awards applicable to recipients.

     Performance-Based Awards.  The Committee may award Common Stock and other
awards that are valued in whole or in part by reference to, or are payable in
or otherwise based on, Common Stock either alone or in addition to or in tandem
with stock options, stock appreciation rights, or restricted stock. Such awards
shall be subject to such terms and conditions as the Committee may prescribe.

     Amendment and Termination.  The Plan provides that it may be amended, in
whole or in part, suspended or terminated by the Board of Directors, except
that no such amendment, suspension or termination, without stockholder approval
to the extent such approval is required by applicable state law, the applicable
provisions of Rule 16b-3 of the Exchange Act or for the exception for
performance-based compensation under Section 162(m) of the Code or to the
extent applicable to incentive stock options, Section 422 of the Code, may
increase the aggregate number of shares of Common Stock reserved for awards or
the maximum individual limits, change the classification of employees eligible
to receive awards, decrease the minimum exercise price of any stock option,
extend the maximum option period under the Plan or to make any other amendment
that would require stockholder approval under the Code, Rule 16b-3 of the
Exchange Act or the rules of any exchange or system on which the Company's
securities are listed or traded.

     Share and Other Limitations.  A maximum of 1,500,000 shares of Common Stock
may be issued or used for reference purposes pursuant to the Plan. The maximum
number of shares of Common Stock subject to stock


                                       14
<PAGE>

options or SARs that may be granted to any individual under the Plan shall be
250,000 for any fiscal year of the Company during the term of the Plan. If an
SAR or a limited SAR is granted in tandem with a stock option, it shall apply
against the individual limits for both stock options and SARs, but only once
against the maximum number of shares available under the Plan. To the extent
that shares of Common Stock for which stock options or SARs are permitted to be
granted to a recipient during a calendar year are not covered by a grant of a
stock option or an SAR during the calendar year, such shares of Common Stock
shall not be available for grant or issuance to the recipient in any subsequent
calendar year during the term of this Plan.

     The Committee may make appropriate adjustments to the number of shares
available for awards and the terms of outstanding awards under the Plan to
reflect any change in the Company's capital structure or business, stock
dividend, stock split, recapitalization, reorganization, merger, consolidation
or sale of all or substantially all the assets of the Company.

     Change in Control.  Unless determined otherwise by the Committee at the
time of grant, upon a Change in Control (as defined in the Plan), all vesting
and forfeiture conditions, restrictions and limitations in effect with respect
to any outstanding award will immediately lapse and any unvested awards will
automatically become 100% vested. The Committee may also, in its sole
discretion, provide for accelerated vesting of an award at any time.

     Miscellaneous.  Although awards will generally be nontransferable (except
by will or the laws of descent and distribution), the Committee may determine
at the time of grant or thereafter that a non-qualified stock option that is
otherwise nontransferable is transferable in whole or in part and in such
circumstances, and under such conditions, as specified by the Committee.

Certain U.S. Federal Income Tax Consequences

     The rules concerning the federal income tax consequences with respect to
stock options granted pursuant to the Plan are highly technical. In addition,
the applicable statutory provisions are subject to change and their application
may vary in individual circumstances. Therefore, the following is designed to
provide a general understanding of the federal income tax consequences; it does
not set forth any state or local income tax or estate tax consequences that may
be applicable.

     Incentive Stock Options.  Options granted under the Plan may be incentive
stock options as defined in the Code, provided that such options satisfy the
requirements under the Code therefor. In general, neither the grant nor the
exercise of an incentive stock option will result in taxable income to the
optionee or a deduction to the Company. The sale of Common Stock received
pursuant to the exercise of an option which satisfied all the requirements of
an incentive stock option, as well as the holding period requirement described
below, will result in a long-term capital gain or loss to the optionee equal to
the difference between the amount realized on the sale and the exercise price
and will not result in a tax deduction to the Company. To receive incentive
stock option treatment, the optionee must not dispose of the Common Stock
purchased pursuant to the exercise of an option either (i) within two years
after the option is granted or (ii) within one year after the date of exercise.
If the Common Stock is held for more than eighteen months after the date of
exercise the optionee will be taxed at a lower rate applicable to capital gains
for such optionee. Capital gains rates may be further reduced in the case of a
longer holding period.

     If all requirements for incentive stock option treatment other than the
holding period rules are satisfied, the recognition of income by the optionee
is deferred until disposition of the Common Stock, but, in general, any gain
(in an amount equal to the lesser of (i) the fair market value of the Common
Stock on the date of exercise (or, with respect to officers, the date that sale
of such stock would not create liability ("Section 16(b) liability") under
Section 16(b) of the Exchange Act) minus the exercise price or (ii) the amount
realized on the disposition minus the exercise price) is treated as ordinary
income. Any remaining gain is treated as long-term or short-term capital gain
depending on the optionee's holding period for the stock disposed of. The
Company generally will be entitled to a deduction at that time equal to the
amount of ordinary income realized by the optionee.


                                       15
<PAGE>

     The Plan provides that an optionee may pay for Common Stock received upon
the exercise of an option (including an incentive stock option) with other
shares of Common Stock held for at least six months. In general an optionee's
transfer of stock acquired pursuant to the exercise of an incentive stock
option, to acquire other stock in connection with the exercise of an incentive
stock option may result in ordinary income if the transferred stock has not met
the minimum statutory holding period necessary for favorable tax treatment as
an incentive stock option. For example, if an optionee exercises an incentive
stock option and uses the stock so acquired to exercise another incentive stock
option within the two-year or one-year holding periods discussed above, the
optionee may realize ordinary income under the rules summarized above.

     Non-Qualified Stock Options.  An optionee will realize no taxable income at
the time he or she is granted a non-qualified stock option. Such conclusion is
predicated on the assumption that, under existing Treasury Department
regulations, a non-qualified stock option, at the time of its grant, has no
readily ascertainable fair market value. Ordinary income will be realized when
a non-qualified stock option is exercised, provided the Common Stock issued is
not restricted stock. The amount of such income will be equal to the excess of
the fair market value on the exercise date of the shares of Common Stock issued
to an optionee over the exercise price. The optionee's holding period with
respect to the shares acquired will begin on the date of exercise.

     The tax basis of the stock acquired upon the exercise of any option will
be equal to the sum of (i) the exercise price of such option and (ii) the
amount included in income with respect to such option. Any gain or loss on a
subsequent sale of the stock will be either a long-term or short-term capital
gain or loss, depending on the optionee's holding period for the stock disposed
of. If the Common Stock issued is restricted stock, different rules may apply.
Subject to the limitation under Sections 162(m) and 280G of the Code (as
described below), the Company generally will be entitled to a deduction for
federal income tax purposes at the same time and in the same amount as the
optionee is considered to have realized ordinary income in connection with the
exercise of the option.

     Certain Other Tax Issues.  In addition, (i) officers of the Company subject
to Section 16(b) liability may be subject to special rules regarding the income
tax consequences concerning their awards; (ii) any entitlement to a tax
deduction on the part of the corporation is subject to the applicable federal
tax rules (including, without limitation, Section 162(m) of the Code regarding
the $1,000,000 limitation on deductible compensation); (iii) in the event that
the exercisability or vesting of any award is accelerated because of a Change
in Control, payments relating to the awards (or a portion thereof), either
alone or together with certain other payments, may constitute parachute
payments under Section 280G of the Code, which excess amounts may be subject to
excise taxes and may be nondeductible by the Company; and (iv) the exercise of
an incentive stock option may have implications in the computation of
alternative minimum taxable income.

     In general, Section 162(m) of the Code denies a publicly held corporation
a deduction for federal income tax purposes for compensation in excess of
$1,000,000 per year per person to its chief executive officer and the four
other officers whose compensation is disclosed in its proxy statement, subject
to certain exceptions. Options and SARs will generally qualify under one of
these exceptions if they are granted under a plan that states the maximum
number of shares with respect to which options and SARs may be granted to any
employee during a specified period and the plan under which the options and
SARs are granted is approved by stockholders and is administered by a
compensation committee comprised of outside directors. The Plan is intended to
satisfy these requirements with respect to options and SARs. Awards of
restricted shares and performance-based awards generally do not satisfy the
exception for performance-based compensation under Section 162(m) of the Code.

     The Plan is not subject to any of the requirements of the Employee
Retirement Income Security Act of 1974, as amended. The Plan is not, nor is it
intended to be, qualified under Section 401(a) of the Code.


                                       16
<PAGE>

                                  PROPOSAL FOUR
                              INDEPENDENT AUDITORS

     The Board of Directors has appointed KPMG Peat Marwick LLP, independent
certified public accountants, to audit the books and records of the Company for
the current year, and the Board recommends that the stockholders of the Company
confirm such appointment.

     Representatives of KPMG Peat Marwick LLP are expected to be present at the
meeting of stockholders and will be given an opportunity to make a statement if
they so desire. They are expected to be available to respond to appropriate
questions.


                                       17
<PAGE>

                             STOCKHOLDERS PROPOSALS

     Stockholders of the Company wishing to include proposals in the proxy
material in relation to the annual meeting of the Company to be held in 1999
must submit the same in writing so as to be received at the executive office of
the Company on or before January 18, 1999. Such proposals must also meet the
other requirements of the rules of the Securities and Exchange Commission
relating to stockholders' proposals.

                                         By Order of the Board of Directors,
                                         JOHN W. JACKSON
                                         Chairman of the Board and
                                         Chief Executive Officer

May 18, 1998

STOCKHOLDERS ARE REQUESTED TO DATE AND SIGN THE ENCLOSED PROXY AND RETURN IT IN
THE ENCLOSED, SELF-ADDRESSED ENVELOPE. NO POSTAGE IS REQUIRED IF MAILED IN THE
UNITED STATES. YOUR PROMPT RESPONSE WILL BE HELPFUL, AND YOUR COOPERATION WILL
BE APPRECIATED.


                                       18
<PAGE>

                                                                      Exhibit A


                              CELGENE CORPORATION

                         1998 LONG-TERM INCENTIVE PLAN
<PAGE>


                               TABLE OF CONTENTS



<TABLE>
<CAPTION>
                                                                             Page
<S>             <C>                                                        <C>
ARTICLE 1.      PURPOSE .................................................   A-1
ARTICLE 2.      DEFINITIONS .............................................   A-1
ARTICLE 3.      ADMINISTRATION. .........................................   A-3
ARTICLE 4.      SHARE AND OTHER LIMITATIONS .............................   A-6
ARTICLE 5.      ELIGIBILITY. ............................................   A-7
ARTICLE 6.      STOCK OPTIONS. ..........................................   A-7
ARTICLE 7.      RESTRICTED STOCK AWARDS. ................................   A-9
ARTICLE 8.      STOCK APPRECIATION RIGHTS. ..............................   A-11
ARTICLE 9.      PERFORMANCE-BASED AWARDS ................................   A-13
ARTICLE 10.     NON-TRANSFERABILITY AND TERMINATION PROVISIONS ..........   A-13
ARTICLE 11.     CHANGE IN CONTROL PROVISIONS ............................   A-15
ARTICLE 12.     TERMINATION OR AMENDMENT OF THE PLAN ....................   A-16
ARTICLE 13.     UNFUNDED STATUS OF PLAN. ................................   A-17
ARTICLE 14.     GENERAL PROVISIONS ......................................   A-17
ARTICLE 15.     APPROVAL OF BOARD AND STOCKHOLDERS ......................   A-19
ARTICLE 16.     TERM OF PLAN ............................................   A-19
ARTICLE 17.     NAME OF PLAN ............................................   A-19
</TABLE>

                                       iii
<PAGE>


<PAGE>

                              CELGENE CORPORATION
                         1998 LONG-TERM INCENTIVE PLAN

                                   ARTICLE 1
                                    PURPOSE

      The purpose of this Celgene Corporation 1998 Long-Term Incentive Plan (the
"Plan") is to enhance the profitability and value of the Company and its
Affiliates for the benefit of its stockholders by enabling the Company to offer
selected management (excluding Non-Employee Directors) and other employees of
the Company and its Affiliates, stock based incentives and other equity
interests in the Company, thereby creating a means to raise the level of stock
ownership by employees in order to attract, retain and reward such employees and
strengthen the mutuality of interests between employees and the Company's
stockholders.

                                    ARTICLE 2
                                   DEFINITIONS

      For purposes of this Plan, the following terms shall have the following
meanings:

            2.1.  "Affiliate" shall mean other than the Company, (i) any
      Subsidiary, (ii) any corporation in an unbroken chain of corporations
      ending with the Company which owns stock possessing 50% or more of the
      total combined voting power of all classes of stock in one of the other
      corporations in such chain, (iii) any corporation, trade or business
      (including, without limitation, a partnership or limited liability
      company) which is controlled 50% or more (whether by ownership of stock,
      assets or an equivalent ownership interest or voting interest) by the
      Company or one of its Affiliates, or (iv) any other entity, approved by
      the Committee as an Affiliate under the Plan, in which the Company or any
      of its Affiliates has a material equity interest.

            2.2.  "Award" shall mean any award under this Plan of any Stock
      Option, Restricted Stock, Stock Appreciation Right, or Performance-Based
      Award. All Awards, shall be granted by, confirmed by, and subject to the
      terms of, a written agreement executed by the Company and the Participant.

            2.3.  "Board" or "Board of Directors" shall mean the Board of
      Directors of the Company.

            2.4.  "Cause" shall mean, with respect to a Participant's
      Termination of Employment: (i) in the case where there is no employment
      agreement, consulting agreement, change in control agreement or similar
      agreement in effect between the Company or an Affiliate and the
      Participant at the time of the relevant grant or Award, or where there is
      an employment agreement, consulting agreement, change in control agreement
      or similar agreement in effect at the time of the relevant grant or Award
      but such agreement does not define "cause" (or words of like import),
      termination due to a Participant's dishonesty, fraud, insubordination,
      willful misconduct, refusal to perform services (for any reason other than
      illness or incapacity) or materially unsatisfactory performance of his or
      her duties for the Company or an Affiliate or (ii) in the case where there
      is an employment agreement, consulting agreement, change in control
      agreement or similar agreement in effect between the Company or an
      Affiliate and the Participant at the time of the relevant grant or Award
      that defines "cause" (or words of like import) and a "cause" termination
      would be permitted under such agreement at that time, termination that is
      or would be deemed to be for "cause" (or words of like import) as defined
      under such agreement; provided, that with regard to any agreement that
      conditions "cause" on occurrence of a change in control, such definition
      of "cause" shall not apply until a change in control actually takes place
      and then only with regard to a termination thereafter.

            2.5.  "Change in Control" shall have the meaning set forth in
      Article 11.

            2.6.  "Code" shall mean the Internal Revenue Code of 1986, as
      amended.

                                      A-1
<PAGE>

            2.7.  "Committee" shall mean a Management Compensation and
      Development Committee or such other committee or subcommittee appointed
      from time to time by the Board, which shall be intended to consist of two
      (2) or more non-employee directors, each of whom shall be, to the extent
      required by Rule 16b-3 (as defined herein), a "non-employee director" as
      defined in Rule 16b-3 and, to the extent required by Section 162(m) of the
      Code and any regulations thereunder, an "outside director" as defined
      under Section 162(m) of the Code. Notwithstanding the foregoing, if and to
      the extent that no Committee exists which has the authority to administer
      the Plan, the functions of the Committee shall be exercised by the Board.
      If for any reason the appointed Committee does not meet the requirements
      of Rule 16b-3 or Section 162(m) of the Code, such noncompliance with the
      requirements of Rule 16b-3 or Section 162(m) of the Code shall not affect
      the validity of the Awards, grants, interpretations or other actions of
      the Committee.

            2.8.  "Common Stock" means the common stock, $.01 par value per
      share, of the Company.

            2.9.  "Company" means Celgene Corporation, a Delaware corporation,
      and its successors by merger, consolidation or otherwise.

            2.10. "Disability" shall mean, with respect to an Eligible Employee,
      a permanent and total disability as defined in Section 22(e)(3) of the
      Code. A Disability shall only be deemed to occur at the time of the
      determination by the Committee or the Board, as the case may be, of the
      Disability.

            2.11. "Effective Date" shall mean May 4, 1998, subject to 
      Article 15.

            2.12. "Eligible Employees" shall mean the employees of the Company
      and its Affiliates who are eligible pursuant to Article 5 to be granted
      Awards under this Plan.

            2.13. "Exchange Act" shall mean the Securities Exchange Act of 1934.

            2.14. "Fair Market Value" for purposes of this Plan, unless
      otherwise required by any applicable provision of the Code or any
      regulations issued thereunder, shall mean, as of any date the last sales
      price reported for the Common Stock on the applicable date (i) as reported
      by the principal national securities exchange in the United States on
      which it is then traded, or (ii) if not traded on any such national
      securities exchange, as quoted on an automated quotation system sponsored
      by the National Association of Securities Dealers. For purposes of the
      exercise of any Stock Appreciation Right the applicable date shall be the
      date a notice of exercise is received by the Committee or, if not a day on
      which the applicable market is open, the next day that it is open.

            2.15. "Incentive Stock Option" shall mean any Stock Option awarded
      under this Plan intended to be and designated as an "Incentive Stock
      Option" within the meaning of Section 422 of the Code.

            2.16. "Limited Stock Appreciation Right" shall mean an Award made
      pursuant to Section 8.5 of the Plan which may be a Tandem Stock
      Appreciation Right or a Non-Tandem Stock Appreciation Right.

            2.17. "Non-Employee Director" shall mean a director of the Company
      who is not an active employee of the Company or an Affiliate.

            2.18. "Non-Qualified Stock Option" shall mean any Stock Option
      awarded under this Plan that is not an Incentive Stock Option.

            2.19. "Participant" shall mean an Eligible Employee to whom an Award
      has been made pursuant to this Plan.

            2.20. "Performance-Based Award" shall mean an Award made pursuant to
      Article 9 of this Plan of the right to receive awards of Common Stock and
      other Awards that are valued in whole or in part by reference to, or are
      payable in or otherwise based on, Common Stock.


                                      A-2
<PAGE>

            2.21. "Performance Period" shall have the meaning set forth in
      Section 9.1.

            2.22. "Restricted Stock" shall mean an award of shares of Common
      Stock under this Plan that is subject to restrictions under Article 7.

            2.23. "Restriction Period" shall have the meaning set forth in
      Subsection 7.3(a) with respect to Restricted Stock for Eligible Employees.

            2.24. "Retirement" shall mean a Participant's Termination of
      Employment without Cause at or after age fifty-five (55).

            2.25. "Rule 16b-3" shall mean Rule 16b-3 under Section 16(b) of the
      Exchange Act as then in effect or any successor provisions.

            2.26. "Section 162(m) of the Code" shall mean the exception for
      performance-based compensation under Section 162(m) of the Code and any
      Treasury regulations thereunder.

            2.27. "Stock Appreciation Right" shall mean the right (pursuant to
      an Award granted under Article 8). A Tandem Stock Appreciation Right shall
      mean the right to surrender to the Company all (or a portion) of a Stock
      Option in exchange for an amount in cash or stock equal to the excess of
      (i) the Fair Market Value, on the date such Stock Option (or such portion
      thereof) is surrendered, of the Common Stock covered by such Stock Option
      (or such portion thereof), over (ii) the aggregate exercise price of such
      Stock Option (or such portion thereof). A Non-Tandem Stock Appreciation
      Right shall mean the right to receive an amount in cash or stock equal to
      the excess of (x) the Fair Market Value of a share of Common Stock on the
      date such right is exercised, over (y) the aggregate exercise price of
      such right, otherwise than on surrender of a Stock Option.

            2.28. "Stock Option" or "Option" shall mean any option to purchase
      shares of Common Stock granted to Eligible Employees pursuant to 
      Article 6.
    

            2.29. "Subsidiary" shall mean any subsidiary corporation of the
      Company within the meaning of Section 424(f) of the Code.

            2.30. "Ten Percent Stockholder" shall mean a person owning stock of
      the Company possessing more than ten percent (10%) of the total combined
      voting power of all classes of stock of the Company or its Subsidiaries or
      its parent corporations, as defined in Section 424(e) of the Code.

            2.31. "Termination of Employment" shall mean (i) a termination of
      service (for reasons other than a military or personal leave of absence
      granted by the Company) of a Participant from the Company and its
      Affiliates or (ii) when an entity which is employing a Participant ceases
      to be an Affiliate, unless the Participant thereupon becomes employed by
      the Company or another Affiliate.

            2.32. "Transfer" or "Transferred" or "Transferable" shall mean
      anticipate, alienate, attach, sell, assign, pledge, encumber, charge,
      hypothecate or otherwise transfer.


                                    ARTICLE 3

                                 ADMINISTRATION

            3.1.  The Committee. The Plan shall be administered and interpreted
      by the Committee.

            3.2.  Awards. The Committee shall have full authority to grant to
      Eligible Employees, pursuant to the terms of this Plan: (i) Stock Options,
      (ii) Restricted Stock, (iii) Stock Appreciation Rights, and (iv)
      Performance-Based Awards. In particular, the Committee shall have the
      authority:


                                      A-3
<PAGE>

                  (a) to select the Eligible Employees to whom Stock Options,
            Restricted Stock, Stock Appreciation Rights, and Performance-Based
            Awards may from time to time be granted hereunder;

                  (b) to determine whether and to what extent Stock Options,
            Restricted Stock, Stock Appreciation Rights, and Performance-Based
            Awards or any combination thereof, are to be granted hereunder to
            one or more Eligible Employees;

                  (c) to determine, in accordance with the terms of this Plan,
            the number of shares of Common Stock to be covered by each Award to
            an Eligible Employee granted hereunder;

                  (d) to determine the terms and conditions, not inconsistent
            with the terms of this Plan, of any Award granted hereunder to an
            Eligible Employee (including, but not limited to, the exercise or
            purchase price, any restriction or limitation, any vesting schedule
            or acceleration thereof, or any forfeiture restrictions or waiver
            thereof, regarding any Stock Option or other Award, and the shares
            of Common Stock relating thereto, based on such factors, if any, as
            the Committee shall determine, in its sole discretion);

                  (e) to determine whether and under what circumstances a Stock
            Option may be settled in cash and/or Common Stock under Section
            6.3(d);

                  (f) to determine whether, to what extent and under what
            circumstances to provide loans (which may be on a recourse basis and
            shall bear interest at the rate the Committee shall provide) to
            Eligible Employees in order to exercise Options under this Plan;

                  (g) to determine whether to require an Eligible Employee, as a
            condition of the granting of any Award, to not sell or otherwise
            dispose of shares acquired pursuant to the exercise of an Option or
            as an Award for a period of time as determined by the Committee, in
            its sole discretion, following the date of the acquisition of such
            Option or Award; and

                  (h) to determine whether a Stock Appreciation Right is a
            Tandem Stock Appreciation Right or Non-Tandem Stock Appreciation
            Right.

            3.3.  Guidelines. Subject to Article 12 hereof, the Committee shall
      have the authority to adopt, alter and repeal such administrative rules,
      guidelines and practices governing this Plan and perform all acts,
      including the delegation of its administrative responsibilities, as it
      shall, from time to time, deem advisable; to construe and interpret the
      terms and provisions of this Plan and any Award issued under this Plan
      (and any agreements relating thereto); and to otherwise supervise the
      administration of this Plan. The Committee may correct any defect, supply
      any omission or reconcile any inconsistency in this Plan or in any
      agreement relating thereto in the manner and to the extent it shall deem
      necessary to carry this Plan into effect but only to the extent any such
      action would be permitted under the applicable provisions of Rule 16b-3
      and Section 162(m) of the Code. The Committee may adopt special guidelines
      and provisions for persons who are residing in, or subject to, the taxes
      of, countries other than the United States to comply with applicable tax
      and securities laws and may impose any limitations and restrictions that
      they deem necessary to comply with the applicable tax and securities laws
      of such countries other than the United States. To the extent applicable,
      the Plan is intended to comply with the applicable requirements of Rule
      16b-3 and the exception for performance-based compensation under Section
      162(m) of the Code with regard to Options and Stock Appreciation Rights
      and shall be limited, construed and interpreted in a manner so as to
      comply therewith.

            3.4.  Decisions Final. Any decision, interpretation or other action
      made or taken in good faith by or at the direction of the Company, the
      Board, or the Committee (or any of its members) arising out of or in
      connection with the Plan shall be within the absolute discretion of all
      and each of them, as the case may be, and


                                      A-4
<PAGE>

      shall be final, binding and conclusive on the Company and all employees
      and Participants and their respective heirs, executors, administrators,
      successors and assigns.

            3.5.  Reliance on Counsel. The Company, the Board or the Committee
      may consult with legal counsel, who may be counsel for the Company or
      other counsel, with respect to its obligations or duties hereunder, or
      with respect to any action or proceeding or any question of law, and shall
      not be liable with respect to any action taken or omitted by it in good
      faith pursuant to the advice of such counsel.

            3.6.  Procedures. If the Committee is appointed, the Board shall
      designate one of the members of the Committee as chairman and the
      Committee shall hold meetings, subject to the By-Laws of the Company, at
      such times and places as it shall deem advisable. A majority of the
      Committee members shall constitute a quorum. All determinations of the
      Committee shall be made by a majority of the members present. Any decision
      or determination reduced to writing and signed by all the Committee
      members in accordance with the By-Laws of the Company, shall be fully as
      effective as if it had been made by a vote at a meeting duly called and
      held. The Committee shall keep minutes of its meetings and shall make such
      rules and regulations for the conduct of its business as it shall deem
      advisable.

            3.7.  Designation of Consultants/Liability.

                  (a) The Committee may designate employees of the Company and
            professional advisors to assist the Committee in the administration
            of the Plan and may grant authority to employees to execute
            agreements or other documents on behalf of the Committee.

                  (b) The Committee may employ such legal counsel, consultants,
            appraisers and agents as it may deem desirable for the
            administration of the Plan and may rely upon any opinion received
            from any such counsel, appraiser or consultant and any computation
            received from any such consultant, appraiser or agent. Expenses
            incurred by the Committee in the engagement of any such counsel,
            consultant or agent shall be paid by the Company. The Board, the
            Committee, its members and any employee of the Company designated
            pursuant to paragraph (a) above shall not be liable for any action
            or determination made in good faith with respect to the Plan. To the
            maximum extent permitted by applicable law, no officer or employee
            of the Company or member or former member of the Committee or of the
            Board shall be liable for any action or determination made in good
            faith with respect to the Plan or any Award granted under it. To the
            maximum extent permitted by applicable law and the Certificate of
            Incorporation and By-Laws of the Company and to the extent not
            covered by insurance, each officer, employee of the Company and
            member or former member of the Committee or of the Board shall be
            indemnified and held harmless by the Company against any cost or
            expense (including reasonable fees of counsel reasonably acceptable
            to the Company) or liability (including any sum paid in settlement
            of a claim with the approval of the Company), and advanced amounts
            necessary to pay the foregoing at the earliest time and to the
            fullest extent permitted, arising out of any act or omission to act
            in connection with the Plan, except to the extent arising out of
            such officer's, employee's, member's or former member's own fraud or
            bad faith. Such indemnification shall be in addition to any rights
            of indemnification the officers, employees, directors or members or
            former officers, directors or members may have under applicable law
            or under the Certificate of Incorporation or By-Laws of the Company
            or Affiliates. Notwithstanding anything else herein, this
            indemnification will not apply to the actions or determinations made
            by an individual with regard to Awards granted to him or her under
            this Plan.


                                      A-5
<PAGE>

                                   ARTICLE 4

                          SHARE AND OTHER LIMITATIONS

            4.1.  Shares.

                  (a) General Limitation. The aggregate number of shares of
            Common Stock which may be issued or used for reference purposes
            under this Plan or with respect to which all Awards may be granted
            shall not exceed 1,500,000 shares (subject to any increase or
            decrease pursuant to Section 4.2). If any Option or Stock
            Appreciation Right granted under this Plan expires, terminates or is
            canceled for any reason without having been exercised in full, the
            number of shares of Common Stock underlying any unexercised Stock
            Appreciation Right or Option shall again be available for the
            purposes of Awards under the Plan. If any shares of Restricted Stock
            awarded under this Plan to a Participant are forfeited for any
            reason, the number of forfeited shares of Restricted Stock shall
            again be available for the purposes of Awards under the Plan. If a
            Tandem Stock Appreciation Right or a Limited Stock Appreciation
            Right is granted in tandem with an Option, such grant shall only
            apply once against the maximum number of shares of Common Stock
            which may be issued under this Plan.

                  (b) Individual Participant Limitations. (i) The maximum number
            of shares of Common Stock subject to any Option which may be granted
            under this Plan during any fiscal year of the Company to each
            Eligible Employee shall be 250,000 shares (subject to any increase
            or decrease pursuant to Section 4.2).

                        (ii) The maximum number of shares of Common Stock
                  subject to any Stock Appreciation Right which may be granted
                  under this Plan during any fiscal year of the Company to each
                  Eligible Employee shall be 250,000 shares (subject to any
                  increase or decrease pursuant to Section 4.2). If a Tandem
                  Stock Appreciation Right or Limited Stock Appreciation Right
                  is granted in tandem with an Option it shall apply against the
                  Eligible Employee's individual share limitations for both
                  Stock Appreciation Rights and Options.

                        (iii) To the extent that shares of Common Stock for
                  which Options or Stock Appreciation Rights are permitted to be
                  granted to a Participant pursuant to Section 4.1(b) during a
                  calendar year of the Company are not covered by a grant of an
                  Option or a Stock Appreciation Right in the Company's calendar
                  year, such shares of Common Stock shall not be available for
                  grant or issuance to the Participant in any subsequent
                  calendar year during the term of this Plan.

            4.2.  Changes.

                  (a) The existence of the Plan and the Awards granted hereunder
            shall not affect in any way the right or power of the Board or the
            stockholders of the Company to make or authorize any adjustment,
            recapitalization, reorganization or other change in the Company's
            capital structure or its business, any merger or consolidation of
            the Company or its Affiliates, any issue of bonds, debentures,
            preferred or prior preference stock ahead of or affecting Common
            Stock, the dissolution or liquidation of the Company or its
            Affiliates, any sale or transfer of all or part of its assets or
            business or any other corporate act or proceeding.

                  (b) In the event of any such change in the capital structure
            or business of the Company by reason of any stock dividend or
            distribution, stock split or reverse stock split, recapitalization,
            reorganization, merger, consolidation, split-up, combination or
            exchange of shares, distribution with respect to its outstanding
            Common Stock or capital stock other than Common Stock,
            reclassification of its capital stock, conversion of the Company's
            preferred stock, issuance of warrants or options to purchase any
            Common Stock or securities convertible into Common Stock, any sale
            or Transfer of all or part of the Company's assets or business, or
            any similar change affecting the Company's capital structure or
            business, then the


                                      A-6
<PAGE>

            aggregate number and kind of shares which thereafter may be issued
            under this Plan, the number and kind of shares or other property
            (including cash) to be issued upon exercise of an outstanding Option
            or other Awards granted under this Plan and the purchase price
            thereof shall be appropriately adjusted consistent with such change
            in such manner as the Committee may deem equitable to prevent
            substantial dilution or enlargement of the rights granted to, or
            available for, Participants under this Plan, and any such adjustment
            determined by the Committee in good faith shall be binding and
            conclusive on the Company and all Participants and employees and
            their respective heirs, executors, administrators, successors and
            assigns.

                  (c) Fractional shares of Common Stock resulting from any
            adjustment in Options or Awards pursuant to Section 4.2(a) or (b)
            shall be aggregated until, and eliminated at, the time of exercise
            by rounding- down for fractions less than one-half (1/2) and
            rounding-up for fractions equal to or greater than one-half (1/2).
            No cash settlements shall be made with respect to fractional shares
            eliminated by rounding. Notice of any adjustment shall be given by
            the Committee to each Participant whose Option or Award has been
            adjusted and such adjustment (whether or not such notice is given)
            shall be effective and binding for all purposes of the Plan.

                  (d) In the event of a merger or consolidation in which the
            Company is not the surviving entity or in the event of any
            transaction that results in the acquisition of substantially all of
            the Company's outstanding Common Stock by a single person or entity
            or by a group of persons and/or entities acting in concert, or in
            the event of the sale or transfer of all or substantially all of the
            Company's assets (all of the foregoing being referred to as
            "Acquisition Events"), then the Committee may, in its sole
            discretion, terminate all outstanding Options and Stock Appreciation
            Rights of Eligible Employees, effective as of the date of the
            Acquisition Event, by delivering notice of termination to each such
            Participant at least twenty (20) days prior to the date of
            consummation of the Acquisition Event; provided, that during the
            period from the date on which such notice of termination is
            delivered to the consummation of the Acquisition Event, each such
            Participant shall have the right to exercise in full all of his or
            her Options and Stock Appreciation Rights that are then outstanding
            (without regard to any limitations on exercisability otherwise
            contained in the Option or Award Agreements) but contingent on
            occurrence of the Acquisition Event, and, provided that, if the
            Acquisition Event does not take place within a specified period
            after giving such notice for any reason whatsoever, the notice and
            exercise shall be null and void.

     If an Acquisition Event occurs, to the extent the Committee does not
terminate the outstanding Options and Stock Appreciation Rights pursuant to
this Section 4.2(d), then the provisions of Section 4.2(b) shall apply.

            4.3.  Purchase Price. Notwithstanding any provision of this Plan to
      the contrary, if authorized but previously unissued shares of Common Stock
      are issued under this Plan, such shares shall not be issued for a
      consideration which is less than as permitted under applicable law.

                                    ARTICLE 5
                                   ELIGIBILITY

     All management (excluding Non-Employee Directors) and other employees of
the Company and its Affiliates are eligible to be granted Options, Restricted
Stock, Stock Appreciation Rights, and Performance-Based Awards under this Plan.
Eligibility under this Plan shall be determined by the Committee in its sole
and absolute discretion.

                                    ARTICLE 6
                                  STOCK OPTIONS

            6.1.  Options. Each Stock Option granted hereunder shall be one of
      two types: (i) an Incentive Stock Option intended to satisfy the
      requirements of Section 422 of the Code or (ii) a Non-Qualified Stock
      Option.


                                      A-7
<PAGE>

            6.2.  Grants. The Committee shall have the authority to grant to any
      Eligible Employee one or more Incentive Stock Options, Non-Qualified Stock
      Options, or both types of Stock Options (in each case with or without
      Stock Appreciation Rights). To the extent that any Stock Option does not
      qualify as an Incentive Stock Option (whether because of its provisions or
      the time or manner of its exercise or otherwise), such Stock Option or the
      portion thereof which does not qualify, shall constitute a separate
      Non-Qualified Stock Option. Notwithstanding any other provision of this
      Plan to the contrary or any provision in an agreement evidencing the grant
      of an Option to the contrary, any Option granted to an Eligible Employee
      of an Affiliate (other than one described in Section 2.1 (i) or (ii))
      shall be a Non-Qualified Stock Option.

            6.3.  Terms of Options. Options granted under Article 6 of this Plan
      shall be subject to Article 10 and the following terms and conditions, and
      shall be in such form and contain such additional terms and conditions,
      not inconsistent with the terms of this Plan, as the Committee shall deem
      desirable:

                  (a) Option Price. The option price per share of Common Stock
            purchasable under an Incentive Stock Option or a Non-Qualified Stock
            Option shall be determined by the Committee at the time of grant but
            shall not be less than 100% of the Fair Market Value of the share of
            Common Stock at the time of grant; provided, however, if an
            Incentive Stock Option is granted to a Ten Percent Stockholder, the
            purchase price shall not be less than 110% of the Fair Market Value
            of the share of Common Stock at the time of grant.

                  (b) Option Term. The term of each Stock Option shall be fixed
            by the Committee, but no Stock Option shall be exercisable more than
            ten (10) years after the date the Option is granted; provided,
            however, that the term of an Incentive Stock Option granted to a Ten
            Percent Stockholder may not exceed five (5) years.

                  (c) Exercisability. Stock Options shall be exercisable at such
            time or times and subject to such terms and conditions as shall be
            determined by the Committee at grant. If the Committee provides, in
            its discretion, that any Stock Option is exercisable subject to
            certain limitations (including, without limitation, that it is
            exercisable only in installments or within certain time periods),
            the Committee may waive such limitations on the exercisability at
            any time at or after grant in whole or in part (including, without
            limitation, that the Committee may waive the installment exercise
            provisions or accelerate the time at which Options may be
            exercised), based on such factors, if any, as the Committee shall
            determine, in its sole discretion.

                  (d) Method of Exercise. Subject to whatever installment
            exercise and waiting period provisions apply under subsection (c)
            above, Stock Options may be exercised in whole or in part at any
            time during the Option term, by giving written notice of exercise to
            the Company specifying the number of shares to be purchased. Such
            notice shall be accompanied by payment in full of the purchase price
            as follows: (i) in cash or by check, bank draft or money order
            payable to the order of Company, (ii) if the Common Stock is traded
            on a national securities exchange, the Nasdaq Stock Market, Inc. or
            quoted on a national quotation system sponsored by the National
            Association of Securities Dealers, through the delivery of
            irrevocable instructions to a broker to deliver promptly to the
            Company an amount equal to the purchase price, (iii) by payment in
            full or part in the form of Common Stock owned by the Participant
            for a period of at least 6 months (and for which the Participant has
            good title free and clear of any liens and encumbrances) based on
            the Fair Market Value of the Common Stock on the payment date as
            determined by the Committee or the Board or (iv) on such other terms
            and conditions as may be acceptable to the Committee or the Board,
            as applicable. No shares of Common Stock shall be issued until
            payment therefor, as provided herein, has been made or provided for.


                                      A-8
<PAGE>

                  (e) Incentive Stock Option Limitations. To the extent that the
            aggregate Fair Market Value (determined as of the time of grant) of
            the Common Stock with respect to which Incentive Stock Options are
            exercisable for the first time by an Eligible Employee during any
            calendar year under the Plan and/or any other stock option plan of
            the Company or any Subsidiary or parent corporation (within the
            meaning of Section 424(e) of the Code) exceeds $100,000, such
            Options shall be treated as Options which are not Incentive Stock
            Options. In addition, if an Eligible Employee does not remain
            employed by the Company, any Subsidiary or parent corporation
            (within the meaning of Section 424(e) of the Code) at all times from
            the time the Option is granted until three (3) months prior to the
            date of exercise (or such other period as required by applicable
            law), such Option shall be treated as an Option which is not an
            Incentive Stock Option.

      Should the foregoing provision not be necessary in order for the Stock
Options to qualify as Incentive Stock Options, or should any additional
provisions be required, the Committee may amend the Plan accordingly, without
the necessity of obtaining the approval of the stockholders of the Company.

      Without the written consent of the Company, no Common Stock acquired by a
Participant upon the exercise of an Incentive Stock Option granted hereunder may
be disposed of by the Participant within two (2) years from the date such
Incentive Stock Option was granted, nor within one (1) year after the transfer
of such Common Stock to the Participant; provided, however, that a transfer to a
trustee, receiver, or other fiduciary in any insolvency proceeding, as described
in Section 422(c)(3) of the Code, shall not be deemed to be such a disposition.

                  (f) Form of Options. Subject to the terms and conditions and
            within the limitations of the Plan, an Option shall be evidenced by
            such form of agreement or grant as is approved by the Committee.

                  (g) Form of Settlement. In its sole discretion, the Committee
            may provide, at the time of grant, that the shares to be issued upon
            the exercise of a Stock Option shall be in the form of Restricted
            Stock, or may, in the Option agreement, reserve a right to so
            provide after the time of grant.

                  (h) Other Terms and Conditions. Options may contain such other
            provisions, which shall not be inconsistent with any of the
            foregoing terms of the Plan, as the Committee shall deem appropriate
            including, without limitation, permitting "reloads." With regard to
            such "reloads", the Committee shall have the authority (but not an
            obligation) to include within any Option agreement a provision
            entitling the optionee to a further Option (a "Reload Option") if
            the optionee exercises the Option evidenced by the Option agreement,
            in whole or in part, by surrendering other shares of the Company
            held by the optionee for at least six (6) months prior to such date
            of surrender in accordance with the Plan and the terms and
            conditions of the Option agreement. Any Reload Option shall not be
            an Incentive Stock Option, shall be for a number of shares equal to
            the number of surrendered shares, the exercise price thereof shall
            be equal to the Fair Market Value of the Common Stock on the date of
            exercise of such original Option, shall become exercisable if the
            purchased shares are held for a minimum period of time established
            by the Committee, and shall be subject to such other terms and
            conditions as the Committee may determine.

                                    ARTICLE 7
                             RESTRICTED STOCK AWARDS

            7.1.  Awards of Restricted Stock. Shares of Restricted Stock may be
      issued to Eligible Employees either alone or in addition to other Awards
      granted under the Plan. The Committee shall determine the eligible persons
      to whom, and the time or times at which, grants of Restricted Stock will
      be made, the number of shares to be awarded, the price (if any) to be paid
      by the recipient (subject to Section 7.2), the time or times within which
      such Awards may be subject to forfeiture, the vesting schedule and rights
      to acceleration thereof, and


                                      A-9
<PAGE>

      all other terms and conditions of the Awards. The Committee may condition
      the grant of Restricted Stock upon the attainment of specified performance
      goals or such other factors as the Committee may determine, in its sole
      discretion.

            7.2.  Awards and Certificates. An Eligible Employee selected to
      receive Restricted Stock shall not have any rights with respect to such
      Award, unless and until such Participant has delivered a fully executed
      copy of the Restricted Stock Award agreement evidencing the Award to the
      Company and has otherwise complied with the applicable terms and
      conditions of such Award. Further, such Award shall be subject to the
      following conditions:

                  (a) Purchase Price. The purchase price of Restricted Stock
            shall be fixed by the Committee. Subject to Section 4.3, the
            purchase price for shares of Restricted Stock may be the minimum
            permitted by applicable law.

                  (b) Acceptance. Awards of Restricted Stock must be accepted
            within a period of ninety (90) days (or such shorter period as the
            Committee may specify at grant) after the Award date, by executing a
            Restricted Stock Award agreement and by paying whatever price (if
            any) the Committee has designated thereunder.

                  (c) Legend. Each Participant receiving a Restricted Stock
            Award shall be issued a stock certificate in respect of such shares
            of Restricted Stock, unless the Committee elects to use another
            system, such as book entries by the transfer agent, as evidencing
            ownership of a Restricted Stock Award. Such certificate shall be
            registered in the name of such Participant, and shall bear an
            appropriate legend referring to the terms, conditions, and
            restrictions applicable to such Award, substantially in the
            following form:

                  "The anticipation, alienation, attachment, sale, transfer,
            assignment, pledge, encumbrance or charge of the shares of stock
            represented hereby are subject to the terms and conditions
            (including forfeiture) of the Celgene Corporation (the "Company")
            1998 Long-Term Incentive Plan and an Agreement entered into between
            the registered owner and the Company dated . Copies of such Plan and
            Agreement are on file at the principal office of the Company."

                  (d) Custody. The Committee may require that any stock
            certificates evidencing such shares be held in custody by the
            Company until the restrictions thereon shall have lapsed, and that,
            as a condition of any Restricted Stock Award, the Participant shall
            have delivered a duly signed stock power, endorsed in blank,
            relating to the Common Stock covered by such Award.

            7.3.  Restrictions and Conditions on Restricted Stock Awards. The
      shares of Restricted Stock awarded pursuant to this Plan shall be subject
      to Article 10 and the following restrictions and conditions:

                  (a) Restriction Period; Vesting and Acceleration of Vesting.
            (i) The Participant shall not be permitted to Transfer shares of
            Restricted Stock awarded under this Plan during a period set by the
            Committee (the "Restriction Period") commencing with the date of
            such Award, as set forth in the Restricted Stock Award agreement and
            such agreement shall set forth a vesting schedule and any events
            which would accelerate vesting of the shares of Restricted Stock.
            Within these limits, based on service, attainment of performance
            goals established pursuant to Section 7.3(a)(ii) below and/or such
            other factors or criteria as the Committee may determine in its sole
            discretion, the Committee may provide for the lapse of such
            restrictions in installments in whole or in part, or may accelerate
            the vesting of all or any part of any Restricted Stock Award and/or
            waive the deferral limitations for all or any part of any Restricted
            Stock Award.

                  (ii) Performance Goals, Formulae or Standards (the
            "Performance Goals"). If the lapse of restrictions is based on the
            attainment of Performance Goals, the Committee shall establish the
            Performance


                                      A-10
<PAGE>

            Goals and the applicable vesting percentage of the Restricted Stock
            Award applicable to each Participant or class of Participants in
            writing prior to the beginning of the applicable fiscal year or at
            such later date as otherwise determined by the Committee and while
            the outcome of the Performance Goals is substantially uncertain.
            Such Performance Goals may incorporate provisions for disregarding
            (or adjusting for) changes in accounting methods, corporate
            transactions (including, without limitation, dispositions and
            acquisitions) and other similar type events or circumstances.

                  (b) Rights as Stockholder. Except as provided in this
            subsection (b) and subsection (a) above and as otherwise determined
            by the Committee, the Participant shall have, with respect to the
            shares of Restricted Stock, all of the rights of a holder of shares
            of Common Stock of the Company including, without limitation, the
            right to receive any dividends, the right to vote such shares and,
            subject to and conditioned upon the full vesting of shares of
            Restricted Stock, the right to tender such shares. Notwithstanding
            the foregoing, the payment of dividends shall be deferred until, and
            conditioned upon, the expiration of the applicable Restriction
            Period, unless the Committee, in its sole discretion, specifies
            otherwise at the time of the Award.

                  (c) Lapse of Restrictions. If and when the Restriction Period
            expires without a prior forfeiture of the Restricted Stock subject
            to such Restriction Period, the certificates for such shares shall
            be delivered to the Participant. All legends shall be removed from
            said certificates at the time of delivery to the Participant except
            as otherwise required by applicable law.

                                    ARTICLE 8

                            STOCK APPRECIATION RIGHTS

            8.1.  Tandem Stock Appreciation Rights. Stock Appreciation Rights
      may be granted in conjunction with all or part of any Stock Option (a
      "Reference Stock Option") granted under this Plan ("Tandem Stock
      Appreciation Rights"). In the case of a Non-Qualified Stock Option, such
      rights may be granted either at or after the time of the grant of such
      Reference Stock Option. In the case of an Incentive Stock Option, such
      rights may be granted only at the time of the grant of such Reference
      Stock Option.

            8.2.  Terms and Conditions of Tandem Stock Appreciation Rights.
      Tandem Stock Appreciation Rights granted hereunder shall be subject to
      such terms and conditions, not nconsistent with the provisions of this
      Plan, as shall be determined from time to time by the Committee, including
      Article 10 and the following:

                  (a) Term. A Tandem Stock Appreciation Right or applicable
            portion thereof granted with respect to a Reference Stock Option
            shall terminate and no longer be exercisable upon the termination or
            exercise of the Reference Stock Option, except that, unless
            otherwise determined by the Committee, in its sole discretion, at
            the time of grant, a Tandem Stock Appreciation Right granted with
            respect to less than the full number of shares covered by the
            Reference Stock Option shall not be reduced until and then only to
            the extent the exercise or termination of the Reference Stock Option
            causes the number of shares covered by the Tandem Stock Appreciation
            Right to exceed the number of shares remaining available and
            unexercised under the Reference Stock Option.

                  (b) Exercisability. Tandem Stock Appreciation Rights shall be
            exercisable only at such time or times and to the extent that the
            Reference Stock Options to which they relate shall be exercisable in
            accordance with the provisions of Article 6 and Article 8.

                  (c) Method of Exercise. A Tandem Stock Appreciation Right may
            be exercised by an optionee by surrendering the applicable portion
            of the Reference Stock Option. Upon such exercise and surrender,


                                      A-11
<PAGE>

            the Participant shall be entitled to receive an amount determined in
            the manner prescribed in this Section 8.2. Stock Options which have
            been so surrendered, in whole or in part, shall no longer be
            exercisable to the extent the related Tandem Stock Appreciation
            Rights have been exercised.

                  (d) Payment. Upon the exercise of a Tandem Stock Appreciation
            Right a Participant shall be entitled to receive up to, but no more
            than, an amount in cash and/or Common Stock (as chosen by the
            Committee in its sole discretion) equal in value to the excess of
            the Fair Market Value of one share of Common Stock over the Option
            price per share specified in the Reference Stock Option multiplied
            by the number of shares in respect of which the Tandem Stock
            Appreciation Right shall have been exercised, with the Committee
            having the right to determine the form of payment.

                  (e) Deemed Exercise of Reference Stock Option. Upon the
            exercise of a Tandem Stock Appreciation Right, the Reference Stock
            Option or part thereof to which such Stock Appreciation Right is
            related shall be deemed to have been exercised for the purpose of
            the limitation set forth in Article 4 of the Plan on the number of
            shares of Common Stock to be issued under the Plan.

            8.3.  Non-Tandem Stock Appreciation Rights. Non-Tandem Stock
      Appreciation Rights may also be granted without reference to any Stock
      Options granted under this Plan.

            8.4.  Terms and Conditions of Non-Tandem Stock Appreciation Rights.
      Non-Tandem Stock Appreciation Rights granted hereunder shall be subject to
      such terms and conditions, not inconsistent with the provisions of this
      Plan, as shall be determined from time to time by the Committee, including
      Article 10 and the following:

                  (a) Term. The term of each Non-Tandem Stock Appreciation Right
            shall be fixed by the Committee, but shall not be greater than ten
            (10) years after the date the right is granted.

                  (b) Exercisability. Non-Tandem Stock Appreciation Rights shall
            be exercisable at such time or times and subject to such terms and
            conditions as shall be determined by the Committee at grant. If the
            Committee provides, in its discretion, that any such right is
            exercisable subject to certain limitations (including, without
            limitation, that it is exercisable only in installments or within
            certain time periods), the Committee may waive such limitation on
            the exercisability at any time at or after grant in whole or in part
            (including, without limitation, that the Committee may waive the
            installment exercise provisions or accelerate the time at which
            rights may be exercised), based on such factors, if any, as the
            Committee shall determine, in its sole discretion.

                  (c) Method of Exercise. Subject to whatever installment
            exercise and waiting period provisions apply under subsection (b)
            above, Non-Tandem Stock Appreciation Rights may be exercised in
            whole or in part at any time during the option term, by giving
            written notice of exercise to the Company specifying the number of
            Non-Tandem Stock Appreciation Rights to be exercised.

                  (d) Payment. Upon the exercise of a Non-Tandem Stock
            Appreciation Right a Participant shall be entitled to receive, for
            each right exercised, up to, but no more than, an amount in cash
            and/or Common Stock (as chosen by the Committee in its sole
            discretion) equal in value to the excess of the Fair Market Value of
            one share of Common Stock on the date the right is exercised over
            the Fair Market Value of one (1) share of Common Stock on the date
            the right was awarded to the Participant.

            8.5.  Limited Stock Appreciation Rights. The Committee may, in its
      sole discretion, grant Tandem and Non-Tandem Stock Appreciation Rights
      either as a general Stock Appreciation Right or as a Limited Stock
      Appreciation Right. Limited Stock Appreciation Rights may be exercised
      only upon the occurrence of a Change in Control or such other event as the
      Committee may, in its sole discretion, designate at the time of grant or


                                      A-12
<PAGE>

      thereafter. Upon the exercise of Limited Stock Appreciation Rights, except
      as otherwise provided in an Award agreement, the Participant shall receive
      in cash or Common Stock, as determined by the Committee, an amount equal
      to the amount (i) set forth in Section 8.2(d) with respect to Tandem Stock
      Appreciation Rights or (ii) set forth in Section 8.4(d) with respect to
      Non-Tandem Stock Appreciation Rights.

                                    ARTICLE 9
                            PERFORMANCE-BASED AWARDS

            9.1.  Performance-Based Awards. Awards of Common Stock and other
      Awards that are valued in whole or in part by reference to, or are payable
      in or otherwise based on, Common Stock ("Performance-Based Awards") may be
      granted either alone or in addition to or in tandem with Stock Options,
      Stock Appreciation Rights, or Restricted Stock.

      Subject to the provisions of this Plan, the Committee shall have authority
to determine the persons to whom and the time or times at which such Awards
shall be made, the number of shares of Common Stock to be awarded pursuant to
such Awards, and all other conditions of the Awards. The Committee may also
provide for the grant of Common Stock under such Awards upon the completion of a
specified Performance Period.

            9.2.  Terms and Conditions. Performance-Based Awards made pursuant
      to this Article 9 shall be subject to the following terms and conditions:

                  (a) Dividends. Unless otherwise determined by the Committee at
            the time of Award, subject to the provisions of the Award agreement
            and this Plan, the recipient of an Award under this Article 9 shall
            be entitled to receive, currently or on a deferred basis, dividends
            or dividend equivalents with respect to the number of shares of
            Common Stock covered by the Award, as determined at the time of the
            Award by the Committee, in its sole discretion.

                  (b) Vesting. Any Award under this Article 9 and any Common
            Stock covered by any such Award shall vest or be forfeited to the
            extent so provided in the Award agreement, as determined by the
            Committee, in its sole discretion.

                  (c) Waiver of Limitation. In the event of the Participant's
            Retirement, Disability or death, or in cases of special
            circumstances, the Committee may, in its sole discretion, waive in
            whole or in part any or all of the limitations imposed hereunder (if
            any) with respect to any or all of an Award under this Article.

                  (d) Purchase Price. Subject to Section 4.3, Common Stock
            issued on a bonus basis under this Article 9 may be issued for no
            cash consideration; Common Stock purchased pursuant to a purchase
            right awarded under this Article 9 shall be priced as determined by
            the Committee.

                                  ARTICLE 10
                NON-TRANSFERABILITY AND TERMINATION PROVISIONS

      The terms and conditions of this Article 10 shall apply to Awards under
this Plan as follows:

            10.1. Nontransferability. No Stock Option, Stock Appreciation Right,
      or Performance-Based Award shall be Transferable by the Participant
      otherwise than by will or by the laws of descent and distribution. All
      Stock Options and all Stock Appreciation Rights shall be exercisable,
      during the Participant's lifetime, only by the Participant or his or her
      legal guardian or representative. Tandem Stock Appreciation Rights shall
      be Transferable, solely to the extent permitted above, only with the
      underlying Stock Option. In addition, except as provided above, no Stock
      Option shall be Transferred (whether by operation of law or otherwise),
      and no Stock


                                      A-13
<PAGE>

      Option shall be subject to execution, attachment or similar process. Upon
      any attempt to Transfer any Stock Option, or in the event of any levy upon
      any Stock Option by reason of any execution, attachment or similar process
      contrary to the provisions hereof, such Stock Option shall immediately
      terminate and become null and void. Notwithstanding the foregoing, the
      Committee may determine at the time of grant or thereafter that a
      Non-Qualified Stock Option that is otherwise not Transferable pursuant to
      this Article 10 is Transferable in whole or in part and in such
      circumstances, and under such conditions, as specified by the Committee.
      Shares of Restricted Stock under Article 7 may not be Transferred prior to
      the date on which shares are issued, or, if later, the date on which any
      applicable restriction, performance or deferral period lapses. No Award
      shall, except as otherwise specifically provided by law or herein, be
      Transferable in any manner, and any attempt to Transfer any such Award
      shall be void, and no such Award shall in any manner be liable for or
      subject to the debts, contracts, liabilities, engagements or torts of any
      person who shall be entitled to such Award, nor shall it be subject to
      attachment or legal process for or against such person.

            10.2. Termination of Employment. The following rules apply with
      regard to the Termination of Employment of a Participant:

                  (a) Termination by Reason of Death. If a Participant's
            Termination of Employment is by reason of death, any Stock Option or
            Stock Appreciation Right held by such Participant, unless otherwise
            determined by the Committee at grant or, if no rights of the
            Participant's estate are reduced, thereafter, may be exercised, to
            the extent exercisable at the Participant's death, by the legal
            representative of the estate, at any time within a period of one (1)
            year from the date of such death, but in no event beyond the
            expiration of the stated term of such Stock Option or Stock
            Appreciation Right.

                  (b) Termination by Reason of Retirement or Disability. If a
            Participant's Termination of Employment is by reason of Retirement
            or Disability, any Stock Option or Stock Appreciation Right held by
            such Participant, unless otherwise determined by the Committee at
            grant or, if no rights of the Participant are reduced, thereafter,
            may be exercised, to the extent exercisable at the Participant's
            termination, by the Participant (or the Participant's legal
            representative to the extent permitted under Section 14.11 or the
            legal representative of the Participant's estate if the Participant
            dies after termination) at any time within a period (the "Retirement
            or Disability Period") which is the longer of (i) up to ten (10)
            years after the date of grant of such Stock Option or Stock
            Appreciation Right, such period to be set on a case by case basis by
            the Committee, or (ii) three (3) years from the date of such
            termination; provided, however, that, if the Participant dies within
            such Retirement or Disability Period, any unexercised Stock Option
            or Stock Appreciation Right held by such Participant shall
            thereafter be exercisable, to the extent to which it was exercisable
            at the time of death, for a period of one (1) year (or such other
            period as the Committee may specify at grant or, if no rights of the
            Participant's estate are reduced, thereafter) from the date of such
            death, but in no event beyond the expiration of the stated term of
            such Stock Option or Stock Appreciation Right.

                  (c) Voluntary Resignation or Involuntary Termination Without
            Cause. If a Participant's Termination of Employment is due to a
            voluntary resignation or by involuntary termination without Cause
            and such termination occurs prior to, or more than ninety (90) days
            after, the occurrence of an event which would be grounds for
            Termination of Employment by the Company for Cause (without regard
            to any notice or cure period requirements), any Stock Option or
            Stock Appreciation Right held by such Participant, unless otherwise
            determined by the Committee at grant or, if no rights of the
            Participant are reduced, thereafter, may be exercised, to the extent
            exercisable at termination, by the Participant at any time within a
            period of thirty (30) days from the date of such termination, but in
            no event beyond the expiration of the stated term of such Stock
            Option or Stock Appreciation Right.


                                      A-14
<PAGE>

                  (d) Termination for Cause. Unless otherwise determined by the
            Committee at grant or, if no rights of the Participant are reduced,
            thereafter, if a Participant's Termination of Employment is for
            Cause for any reason, any Stock Option or Stock Appreciation Right
            held by such Participant shall thereupon terminate and expire as of
            the date of termination. In the event the termination is an
            involuntary termination without Cause or is a voluntary resignation
            within ninety (90) days after occurrence of an event which would be
            grounds for Termination of Employment by the Company for Cause
            (without regard to any notice or cure period requirement), any Stock
            Option or Stock Appreciation Right held by the Participant at the
            time of occurrence of the event which would be grounds for
            Termination of Employment by the Company for Cause shall be deemed
            to have terminated and expired upon occurrence of the event which
            would be grounds for Termination of Employment by the Company for
            Cause.

                  (e) Termination of Employment for Restricted Stock. Subject to
            the applicable provisions of the Restricted Stock Award agreement
            and this Plan, upon a Participant's Termination of Employment for
            any reason during the relevant Restriction Period, all Restricted
            Stock still subject to restriction will vest or be forfeited in
            accordance with the terms and conditions established by the
            Committee at grant or thereafter.

                  (f) Termination of Employment for Performance-Based Awards.
            Subject to the applicable provisions of the Award agreement and this
            Plan, upon a Participant's Termination of Employment for any reason,
            the Performance-Based Award in question will vest or be forfeited in
            accordance with the terms and conditions established by the
            Committee at grant or thereafter.

                                   ARTICLE 11
                          CHANGE IN CONTROL PROVISIONS

            11.1. Benefits. In the event of a Change in Control of the Company
      (as defined below), except as otherwise provided by the Committee upon the
      grant of an Award, the Participant shall be entitled to the following
      benefits:

                  (a) All outstanding Stock Options and the related Tandem Stock
            Appreciation Rights and Non-Tandem Stock Appreciation Rights of such
            Participant, if any, granted prior to the Change in Control shall be
            fully vested and immediately exercisable in their entirety.

                  (b) All unvested Restricted Stock and Performance-Based Awards
            shall become fully vested upon a Change in Control, including
            without limitation, the following: (i) the restrictions to which any
            shares of Restricted Stock of a Participant granted prior to the
            Change in Control are subject shall lapse as if the applicable
            Restriction Period had ended upon such Change in Control and (ii)
            the conditions required for vesting of any unvested
            Performance-Based Awards shall be deemed to be satisfied upon such
            Change in Control.

            11.2. Change in Control. A "Change in Control" shall mean the
      occurrence of any of the following:

                  (a) any person (as defined in Section 3(a)(9) of the Exchange
            Act and as used in Sections 13(d) and 14(d) thereof), excluding the
            Company, any subsidiary of the Company and any employee benefit plan
            sponsored or maintained by the Company or any subsidiary of the
            Company (including any trustee of any such plan acting in his
            capacity as trustee), becoming the "beneficial owner" (as defined in
            Rule 13d-3 under the Exchange Act) of securities of the Company
            representing thirty percent (30%) of the total combined voting power
            of the Company's then outstanding securities;


                                      A-15
<PAGE>

                  (b) the merger, consolidation or other business combination of
            the Company (a "Transaction"), other than (A) a Transaction
            involving only the Company and one or more of its subsidiaries, or
            (B) a Transaction immediately following which the stockholders of
            the Company immediately prior to the Transaction continue to have a
            majority of the voting power in the resulting entity and no person
            (other than those covered by the exceptions in (a) above) becomes
            the beneficial owner of securities of the resulting entity
            representing more than twenty-five percent (25%) of the voting power
            in the resulting entity;

                  (c) during any period of two (2) consecutive years beginning
            on or after the Effective Date, the persons who were members of the
            Board immediately before the beginning of such period (the
            "Incumbent Directors") ceasing (for any reason other than death) to
            constitute at least a majority of the Board or the board of
            directors of any successor to the Company, provided that, any
            director who was not a director as of the Effective Date shall be
            deemed to be an Incumbent Director if such director was elected to
            the board of directors by, or on the recommendation of or with the
            approval of, at least two-thirds of the directors who then qualified
            as Incumbent Directors either actually or by prior operation of the
            foregoing unless such election, recommendation or approval occurs as
            a result of an actual or threatened election contest (as such terms
            are used in Rule 14a-11 of Regulation 14A promulgated under the
            Exchange Act or any successor provision) or other actual or
            threatened solicitation of proxies or contests by or on behalf of a
            person other than a member of the Board; or

                  (d) the approval by the stockholders of the Company of any
            plan of complete liquidation of the Company or an agreement for the
            sale of all or substantially all of the Company's assets other than
            the sale of all or substantially all of the assets of the Company to
            a person or persons who beneficially own, directly or indirectly, at
            least fifty percent (50%) or more of the combined voting power of
            the outstanding voting securities of the Company at the time of such
            sale.

                                   ARTICLE 12
                      TERMINATION OR AMENDMENT OF THE PLAN

      Notwithstanding any other provision of this Plan, the Board may at any
time, and from time to time, amend, in whole or in part, any or all of the
provisions of the Plan, or suspend or terminate it entirely, retroactively or
otherwise; provided, however, that, unless otherwise required by law or
specifically provided herein, the rights of a Participant with respect to Awards
granted prior to such amendment, suspension or termination, may not be impaired
without the consent of such Participant and, provided further, without the
approval of the stockholders of the Company in accordance with the laws of the
State of Delaware, to the extent required by the applicable provisions of Rule
16b-3 or Section 162(m) of the Code, or, with regard to Incentive Stock Options,
Section 422 of the Code, no amendment may be made which would (i) increase the
aggregate number of shares of Common Stock that may be issued under this Plan or
the maximum individual Participant limitations under Section 4.1(b), (ii) change
the classification of employees eligible to receive Awards under this Plan,
(iii) decrease the minimum option price of any Stock Option, (iv) extend the
maximum option period under Section 6.3, or (v) require stockholder approval in
order for the Plan to continue to comply with the applicable provisions of Rule
16b-3 or Section 162(m) of the Code, or, with regard to Incentive Stock Options,
Section 422 of the Code. In no event may the Plan be amended without the
approval of the stockholders of the Company in accordance with the applicable
laws or other requirements to increase the aggregate number of shares of Common
Stock that may be issued under the Plan, decrease the minimum option price of
any Stock

      Option, or to make any other amendment that would require stockholder
approval under the rules of any exchange or system on which the Company's
securities are listed or traded at the request of the Company.


                                      A-16
<PAGE>

      The Committee may amend the terms of any Award theretofore granted,
prospectively or retroactively, but, subject to Article 4 above or as otherwise
specifically provided herein, no such amendment or other action by the Committee
shall impair the rights of any holder without the holder's consent.

                                   ARTICLE 13
                             UNFUNDED STATUS OF PLAN

      This Plan is intended to constitute an "unfunded" plan for incentive
compensation. With respect to any payments as to which a Participant has a fixed
and vested interest but which are not yet made to a Participant by the Company,
nothing contained herein shall give any such Participant any rights that are
greater than those of a general creditor of the Company.

                                   ARTICLE 14
                               GENERAL PROVISIONS

            14.1. Legend. The Committee may require each person receiving shares
      of Common Stock pursuant to an Award under the Plan to represent to and
      agree with the Company in writing that the Participant is acquiring the
      shares without a view to distribution thereof, and that any subsequent
      offer for sale or sale of any such shares of Common Stock shall be made
      either pursuant to (i) a registration statement on an appropriate form
      under the Securities Act of 1933, which registration statement shall have
      become effective and shall be current with respect to the shares of Common
      Stock being offered and sold, or (ii) a specific exemption from the
      registration requirements of the Securities Act of 1933, and that in
      claiming such exemption the Participant will, prior to any offer for sale
      or sale of shares of Common Stock, obtain a favorable written opinion,
      satisfactory in form and substance to the Company, from counsel acceptable
      to the Company as to the availability of such exception. In addition to
      any legend required by this Plan, the certificates for such shares may
      include any legend which the Committee deems appropriate to reflect any
      restrictions on Transfer.

            All certificates for shares of Common Stock delivered under the Plan
      shall be subject to such stock transfer orders and other restrictions as
      the Committee may deem advisable under the rules, regulations and other
      requirements of the Securities and Exchange Commission, any stock exchange
      upon which the Common Stock is then listed or any national securities
      association system upon whose system the Common Stock is then quoted, any
      applicable Federal or state securities law, and any applicable corporate
      law, and the Committee may cause a legend or legends to be put on any such
      certificates to make appropriate reference to such restrictions.

            14.2. Other Plans. Nothing contained in this Plan shall prevent the
      Board from adopting other or additional compensation arrangements, subject
      to stockholder approval if such approval is required; and, such
      arrangements may be either generally applicable or applicable only in
      specific cases.

            14.3. No Right to Employment. Neither this Plan nor the grant of any
      Award hereunder shall give any Participant or other employee any right
      with respect to continuance of employment by the Company or any Affiliate,
      nor shall there be a limitation in any way on the right of the Company or
      any Affiliate by which an employee is employed to terminate his employment
      at any time.

            14.4. Withholding of Taxes. The Company shall have the right to
      deduct from any payment to be made to a Participant, or to otherwise
      require, prior to the issuance or delivery of any shares of Common Stock
      or the payment of any cash hereunder, payment by the Participant of, any
      Federal, state or local taxes required by law to be withheld. Upon the
      vesting of Restricted Stock, or upon making an election under Section
      83(b) of the Code, a Participant shall pay all required withholding to the
      Company.


                                      A-17
<PAGE>

            At the discretion of the Committee, any such withholding obligation
      with regard to any Participant may be satisfied by reducing the number of
      shares of Common Stock otherwise deliverable or by delivering shares of
      Common Stock already owned. Any fraction of a share of Common Stock
      required to satisfy such tax obligations shall be disregarded and the
      amount due shall be paid instead in cash by the Participant.

            14.5. Listing and Other Conditions.

                  (a) As long as the Common Stock is listed on a national
            securities exchange or system sponsored by a national securities
            association, the issue of any shares of Common Stock pursuant to an
            Award shall be conditioned upon such shares being listed on such
            exchange or system. The Company shall have no obligation to issue
            such shares unless and until such shares are so listed, and the
            right to exercise any Option with respect to such shares shall be
            suspended until such listing has been effected.

                  (b) If at any time counsel to the Company shall be of the
            opinion that any sale or delivery of shares of Common Stock pursuant
            to an Award is or may in the circumstances be unlawful or result in
            the imposition of excise taxes on the Company under the statutes,
            rules or regulations of any applicable jurisdiction, the Company
            shall have no obligation to make such sale or delivery, or to make
            any application or to effect or to maintain any qualification or
            registration under the Securities Act of 1933, as amended, or
            otherwise with respect to shares of Common Stock or Awards, and the
            right to exercise any Option shall be suspended until, in the
            opinion of said counsel, such sale or delivery shall be lawful or
            will not result in the imposition of excise taxes on the Company.

                  (c) Upon termination of any period of suspension under this
            Section 14.5, any Award affected by such suspension which shall not
            then have expired or terminated shall be reinstated as to all shares
            available before such suspension and as to shares which would
            otherwise have become available during the period of such
            suspension, but no such suspension shall extend the term of any
            Option.

            14.6. Governing Law. This Plan shall be governed and construed in
      accordance with the laws of the State of Delaware (regardless of the law
      that might otherwise govern under applicable Delaware principles of
      conflict of laws).

            14.7. Construction. Wherever any words are used in this Plan in the
      masculine gender they shall be construed as though they were also used in
      the feminine gender in all cases where they would so apply, and wherever
      any words are used herein in the singular form they shall be construed as
      though they were also used in the plural form in all cases where they
      would so apply.

            14.8. Other Benefits. No Award payment under this Plan shall be
      deemed compensation for purposes of computing benefits under any
      retirement plan of the Company or its Affiliates nor affect any benefits
      under any other benefit plan now or subsequently in effect under which the
      availability or amount of benefits is related to the level of
      compensation.

            14.9. Costs. The Company shall bear all expenses included in
      administering this Plan, including expenses of issuing Common Stock
      pursuant to any Awards hereunder.

            14.10. No Right to Same Benefits. The provisions of Awards need not
      be the same with respect to each Participant, and such Awards to
      individual Participants need not be the same in subsequent years.

            14.11. Death/Disability. The Committee may in its discretion require
      the transferee of a Participant to supply it with written notice of the
      Participant's death or Disability and to supply it with a copy of the will
      (in the case of the Participant's death) or such other evidence as the
      Committee deems necessary to establish the validity of the transfer of an
      Award. The Committee may also require the agreement of the transferee to


                                      A-18
<PAGE>

      be bound by all of the terms and conditions of the Plan. If the Committee
      shall find, without any obligation or responsibility of any kind to do so,
      that any person to whom payment is payable under this Plan is unable to
      care for his or her affairs because of disability, illness or accident,
      any payment due may be paid to such person's duly appointed legal
      representative in such manner and proportions as the Committee may
      determine, in it sole discretion. Any such payment shall be a complete
      discharge of the liabilities of the Committee and the Board under this
      Plan.

            14.12. Section 16(b) of the Exchange Act. All elections and
      transactions under the Plan by persons subject to Section 16 of the
      Exchange Act involving shares of Common Stock are intended to comply with
      any applicable exemptive condition under Rule 16b-3. The Committee may
      establish and adopt written administrative guidelines, designed to
      facilitate compliance with Section 16(b) of the Exchange Act, as it may
      deem necessary or proper for the administration and operation of the Plan
      and the transaction of business thereunder.

            14.13. Severability of Provisions. If any provision of the Plan
      shall be held invalid or unenforceable, such invalidity or
      unenforceability shall not affect any other provisions hereof, and the
      Plan shall be construed and enforced as if such provisions had not been
      included.

            14.14. Headings and Captions. The headings and captions herein are
      provided for reference and convenience only, shall not be considered part
      of the Plan, and shall not be employed in the construction of the Plan.

                                   ARTICLE 15
                       APPROVAL OF BOARD AND STOCKHOLDERS

      The Plan shall not be effective unless and until approved by the Board
and, solely to the extent required by any applicable law (including without
limitation, approval required under Rule 16b-3, Section 162(m) of the Code or
Section 422 of the Code) or registration or stock exchange rule, approved by the
stockholders of the Company in the manner set forth in such law, regulation or
rule.

                                   ARTICLE 16
                                  TERM OF PLAN

      No Award shall be granted pursuant to the Plan on or after the tenth
anniversary of the earlier of the date the Plan is adopted or the date of
stockholder approval (if applicable), but Awards granted prior to such tenth
anniversary may extend beyond that date.

                                   ARTICLE 17
                                  NAME OF PLAN

      This Plan shall be known as the Celgene Corporation 1998 Long-Term
Incentive Plan.


                                      A-19

<PAGE>

                              CELGENE CORPORATION

                                   P R O X Y


  The undersigned hereby appoints John W. Jackson and Sol J. Barer, and each of
them, with power of substitution, to represent and to vote on behalf of the
undersigned all of the shares of Celgene Corporation (the "Company") which the
undersigned is entitled to vote at the Annual Meeting of Stockholders to be
held at the offices of Proskauer Rose LLP, 26th floor, 1585 Broadway, New York,
New York 10036 on Tuesday, June 23, 1998, at 1:00 p.m., local time, and at any
adjournment or adjournments thereof, hereby revoking all proxies heretofore
given with respect to such stock, upon the following proposals more fully
described in the notice of and proxy statement for the meeting (receipt of
which is hereby acknowledged).
<PAGE>

      Please mark your
      votes as in this
A [X] example using
      dark ink only.



- --------------------------------------------------------------------------------
       THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR (1), (2), (3) AND (4)

<TABLE>
<CAPTION>

<S>                      <C>                          <C>                                 <S>
                                                       WITHHOLD                                               
1. ELECTION OF           FOR                          AUTHORITY                           Nominees:                          
   DIRECTORS             [_] all nominees                [_]    to vote for all           John W. Jackson           
                             listed at right                    nominees listed           Sol J. Barer              
                             (except as                         AT RIGHT                  Frank T. Cary             
                             marked to                                                    Richard C.E. Morgan       
                             the contary)                                                 Walter L. Robb            
                                                                                          Lee J. Schroeder          
INSTRUCTION: TO WITHHOLD AUTHORITY TO VOTE FOR ANY INDIVIDUAL,                            Arthur Hull Hayes, Jr.    
WRITE THAT NOMINEE'S NAME ON THE SPACE PROVIDED BELOW:                                    Gilla Kaplan              
                                                                                          James Bowman              
- -------------------------------------                                                                               
</TABLE>

                                                  FOR       AGAINST      ABSTAIN


2. PROPOSAL TO APPROVE THE AMENDMENT OF           [_]          [_]         [_]
   THE CERTIFICATE OF INCORPORATION TO
   INCREASE THE NUMBER OF AUTHORIZED
   SHARES OF COMMON STOCK FROM 20,000,000
   TO 30,000,000
   
3. PROPOSAL TO APPROVE THE CELGENE                [_]          [_]         [_]
   CORPORATION 1998 LONG-TERM INCENTIVE
   PLAN

4. PROPOSAL TO APPROVE THE APPOINTMENT OF         [_]          [_]         [_]
   KPMG PEAT MARWICK LLP AS THE INDEPENDENT
   CERTIFIED PUBLIC ACCOUNTANTS OF THE
   COMPANY.

5. In their discretion, upon such other matters as may properly come before the
   meeting.

   THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS.

   THIS PROXY, WHEN PROPERLY EXECUTED, WILL BE VOTED IN THE MANNER DIRECTED
   HEREIN BY THE UNDERSIGNED STOCKHOLDER. IF NO DIRECTION IS MADE, THIS PROXY
   WILL BE VOTED FOR ELECTION OF ALL NOMINEES FOR DIRECTOR LISTED IN PROPOSAL 1
   AND FOR PROPOSALS 2, 3, AND 4.

[_]  I will attend the meeting   [_]  I will not attend the meeting
 
 
- -----------------------------  ----------------  --------------------  ---------
      SIGNATURE                DATED             SIGNATURE             DATED

             PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY PROMPTLY
                          USING THE ENCLOSED ENVELOPE.


Note: Please sign exactly as name appears on this proxy. Where shares are held
by joint tenants, both should sign. If signing as attorney, executor,
administrator, trustee or guardian, please give full title as such. If a
corporation, please sign in full corporate name by president or other
authorized person. If a partnership, please sign in partnership name by an
authorized person.



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