CELGENE CORP /DE/
S-8, 1999-01-04
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                           Registration No. 333-
- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                             ----------------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                             ----------------------

                               CELGENE CORPORATION
             (Exact name of registrant as specified in its charter)


            Delaware                                      22-2711928
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
 incorporation or organization)

                               7 Powder Horn Drive
                            Warren, New Jersey 07059
                                 (732) 271-1001
               (Address of principal executive offices) (Zip code)

                            -------------------------

                       Celgene Corporation 1998 Long-Term
                                 Incentive Plan

                        Non-Plan Stock Option Agreements

                            -------------------------


         John W. Jackson                                     Copies to:
       Celgene Corporation                               Robert A. Cantone
       7 Powder Horn Drive                              Proskauer Rose LLP
    Warren, New Jersey 07059                               1585 Broadway
         (732) 271-1001                           New York, New York  10036-8299
Name, address, including zip code,                        (212) 969-3000
 and telephone number, including
 area code, of agent for service)
                                  

                            -------------------------


                                        1

<PAGE>

<TABLE>


                         CALCULATION OF REGISTRATION FEE


<CAPTION>

- ----------------------------------------------------------------------------------------------------------------
                                                     Proposed maximum    Proposed maximum          Amount of
Title of securities to be      Amount to be           offering price     aggregate offering      registration
      registered                registered              per share              price                  fee
- --------------------------   ---------------------   ----------------   --------------------   -----------------
<S>                           <C>                        <C>               <C>                     <C>      
Common Stock, par             1,500,000 shares (1)       $11.59  (2)       $17,385,000 (2)         $4,833.03
value $.01 per share
- ----------------------------------------------------------------------------------------------------------------
Common Stock, par               200,000 shares (3)       $ 5.75  (4)       $ 1,150,000 (4)         $  230.00
value $.01 per share
- ----------------------------------------------------------------------------------------------------------------
Common Stock, par               150,000 shares (5)       $ 6.88  (6)       $ 1,032,000 (6)         $  286.90
value $.01 per share
- ----------------------------------------------------------------------------------------------------------------
Common Stock, par                25,000 shares (7)       $10.625 (8)       $   265,625 (8)         $   73.84
value $.01 per share
- ----------------------------------------------------------------------------------------------------------------
Common Stock, par                15,000 shares (9)       $ 7.00 (10)       $   105,000(10)         $   21.00
value $.01 per share
- ----------------------------------------------------------------------------------------------------------------
TOTAL                                                                                              $5,444.77

</TABLE>


(1)  Represents the maximum number of shares of common stock, par value $.01 per
     share ("Common  Stock"),  issuable upon exercise of options which may be or
     have been granted under the Celgene  Corporation  1998 Long-Term  Incentive
     Plan (the "Plan").  Pursuant to Rule 416,  there are also being  registered
     such additional  indeterminate number of shares as may be required to cover
     possible  adjustments  in the  number  of  shares  issuable  under the Plan
     pursuant to the antidilution provisions thereof.

(2)  Estimated  solely  for the  purpose of  calculating  the  registration  fee
     pursuant to Rule 457(h)(i) of the Securities Act of 1933, as amended ("Rule
     457(h)"),  on the basis of the average of the high and low  selling  prices
     per share of Common Stock on December  14, 1998,  as reported on the Nasdaq
     National Market.

(3)  Represents 200,000 shares of Common Stock issuable upon exercise of options
     which  have been  granted  to Jack L.  Ufheil  pursuant  to a Stock  Option
     Agreement,  dated as of June 21, 1990 between  Celgene  Corporation and Mr.
     Ufheil.

(4)  Estimated  solely  for the  purpose of  calculating  the  registration  fee
     pursuant to Rule  457(h) and based on an exercise  price of $5.75 per share
     with respect to options granted to purchase 200,000 shares of Common Stock.

(5)  Represents 150,000 shares of Common Stock issuable upon exercise of options
     which have been  granted to Richard G. Wright  pursuant  to a Stock  Option
     Agreement,  dated as of March 21, 1994 between Celgene  Corporation and Mr.
     Wright.

(6)  Estimated  solely  for the  purpose of  calculating  the  registration  fee
     pursuant to Rule  457(h) and based on an exercise  price of $6.88 per share
     with respect to options granted to purchase 150,000 shares of Common Stock.

(7)  Represents  25,000 shares of Common Stock issuable upon exercise of options
     which  have been  granted  to Jack L.  Ufheil  pursuant  to a Stock  Option
     Agreement  dated as of August 2, 1993 between  Celgene  Corporation and Mr.
     Ufheil.

(8)  Estimated  solely  for the  purpose of  calculating  the  registration  fee
     pursuant to Rule 457(h) and based on an exercise price of $10.625 per share
     with respect to options granted to purchase 25,000 shares of Common Stock.

(9)  Represents  15,000 shares of Common Stock issuable upon exercise of options
     which  have  been  granted  to  Gilla  Kaplan  pursuant  to a Stock  Option
     Agreement dated as of January 26, 1994 between Celgene  Corporation and Ms.
     Kaplan.

(10) Estimated  solely  for the  purpose of  calculating  the  registration  fee
     pursuant to Rule  457(h) and based on an exercise  price of $7.00 per share
     with respect to options granted to purchase 15,000 shares of Common Stock.


                                        2

<PAGE>



                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS


     The  Section  10(a)  prospectus  for the Plan is not being  filed  with the
Securities  and  Exchange   Commission  (the   "Commission")  as  part  of  this
Registration Statement.


                                        3

<PAGE>


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

     Item 3. Incorporation of Documents by Reference.
     ------- ----------------------------------------

     The following  documents filed with the Securities and Exchange  Commission
by  Celgene   Corporation,   a  Delaware   corporation  (the  "Company"  or  the
"Registrant"), are incorporated herein by reference:

          (1)  the  Company's  Annual  Report on Form 10-K for the  fiscal  year
               ended  December 31, 1997,  filed with the Commission on March 31,
               1998.

          (2)  the  Company's  Amendment to the Annual Report on Form 10-K/A for
               the  fiscal  year  ended  December  31,  1997,   filed  with  the
               Commission on April 30, 1998.

          (3)  the Company's Quarterly Reports filed on Form 10-Q for the fiscal
               quarters  ended March 31, 1998,  June 30, 1998 and  September 30,
               1998.

          (4)  the  Company's  Current  Reports  on Form  8-K,  filed  with  the
               Commission on July 17, 1998 and July 22, 1998.

          (5)  the  description of the Company's  Common Stock  contained in the
               Company's  Registration  Statement on Form 8-A, File No. 0-16132,
               including  any  amendment  or  report  filed for the  purpose  of
               updating such description.

     All documents  subsequently filed by the Company pursuant to Section 13(a),
13(c), 14, or 15(d) of the Securities  Exchange Act of 1934, prior to the filing
of a post-effective  amendment which indicates that all securities  offered have
been sold or which  deregisters all securities then remaining  unsold,  shall be
deemed to be incorporated by reference in this Registration  Statement and to be
part hereof from the date of filing such documents.  Any statement in a document
incorporated or deemed to be incorporated by reference herein shall be deemed to
be modified or superseded for the purposes of this Registration Statement to the
extent  that a statement  contained  herein or in any other  subsequently  filed
document  which  also is or is deemed to be  incorporated  by  reference  herein
modifies or supersedes such  statement.  Any statement so modified or superseded
shall not be deemed,  except as so modified or superseded,  to constitute a part
of this Registration Statement.

     Item 4. Description of Securities.
     ------- --------------------------

     Not applicable.

     Item 5. Interests of Named Experts and Counsel.
     ------- ---------------------------------------

     Not applicable.

     Item 6. Indemnification of Directors and Officers.
     ------- ------------------------------------------

     Article EIGHTH of the Company's Certificate of Incorporation  provides that
the  Corporation  shall  indemnify,  to the  fullest  extent  authorized  by the
Delaware  General  Corporation  Law,  its  officers  and  directors  against all
expenses, judgments, fines and amounts paid in settlement incurred in connection
with any  civil,  criminal,  administrative  or  investigative  action,  suit or
proceeding.  The Certificate of Incorporation  also extends  indemnification  to
those serving at the request of the Company as directors, officers, employees or
agents of other enterprises.


                                      II-1

<PAGE>



     Article TENTH of the Company's  Certificate of Incorporation  provides that
no  director  of the  Company  shall  be  liable  to the  Company  or any of its
stockholders  for monetary  damages for breach of fiduciary  duty as a director,
except for director's liability (i) for breach of the director's duty of loyalty
to the  Company  or its  stockholders,  (ii)  for acts of or  omissions  of such
director not in good faith or which involve intentional  misconduct or a knowing
violation of law,  (iii) under Section 174 of the Delaware  General  Corporation
Law, or (iv) for any  transaction  from which the  director  derived an improper
personal benefit.

     Section 145 of the General Corporation Law of the State of Delaware permits
a  corporation  to  indemnify  its  directors  and  officers   against  expenses
(including  attorney's fees),  judgments,  fines and amounts paid in settlements
actually and reasonably  incurred by them in connection with any action, suit or
proceeding brought by third parties, if such directors or officers acted in good
faith and in a manner  they  reasonably  believed to be in or not opposed to the
best interests of the  corporation  and, with respect to any criminal  action or
proceeding, had no reason to believe their conduct was unlawful. In a derivative
action, i.e., one by or in the right of the corporation,  indemnification may be
made only for  expenses  actually  and  reasonably  incurred  by  directors  and
officers in connection  with the defense or settlement of an action or suit, and
only with  respect  to a matter as to which  they shall have acted in good faith
and in a manner  they  reasonably  believed  to be in or not opposed to the best
interest of the  corporation,  except that no  indemnification  shall be made if
such person shall have been adjudged liable to the corporation,  unless and only
to the  extent  that the court in which the  action  or suit was  brought  shall
determine  upon  application  that  the  defendant  officers  or  directors  are
reasonably  entitled to indemnity for such expenses despite such adjudication of
liability.

     Section  102(b)(7) of the General  Corporation Law of the State of Delaware
provides that a corporation  may eliminate or limit the personal  liability of a
director to the corporation or its  stockholders for monetary damages for breach
of  fiduciary  duty as a  director,  provided  that  such  provision  shall  not
eliminate  or limit  the  liability  of a  director  (i) for any  breach  of the
director's duty of loyalty to the corporation or its stockholders, (ii) for acts
or omissions  not in good faith or which  involve  intentional  misconduct  or a
knowing violation of law, (iii) under Section 174 of the General Corporation Law
of the State of Delaware,  or (iv) for any  transaction  from which the director
derived an improper personal benefit. No such provision shall eliminate or limit
the liability of a director for any act or omission  occurring prior to the date
when such provision becomes effective.

     Pursuant  to Section  145 of the  General  Corporation  Law of the State of
Delaware,  the Company maintains  directors' and officers'  liability  insurance
coverage.

     Item 7. Exemption from Registration Claimed.
     ------- ------------------------------------

     Not applicable.

     Item 8. Exhibits.
     ------- ---------

     4.1  Celgene  Corporation  1998 Long-Term  Incentive Plan  (incorporated by
          reference to Exhibit A to the Proxy Statement of the Registrant, filed
          May 18, 1998)

     5.1  Opinion of Proskauer Rose LLP

     23.1 Consent of KPMG LLP

     23.2 Consent of Proskauer Rose LLP (included in Exhibit 5.1)

     24.1 Power of Attorney (see signature page)

     Item 9. Undertakings.
     ------- -------------

     (a)  The undersigned Registrant hereby undertakes:


                                      II-2

<PAGE>



          (1)  to file,  during  any  period in which  offers or sales are being
               made, a post-effective amendment to this registration statement:

               (i) to include any prospectus required by Section 10(a)(3) of the
          Securities Act of 1933;

               (ii) to reflect  in the  prospectus  any facts or events  arising
          after the effective  date of the  registration  statement (or the most
          recent post-effective amendment thereof) which, individually or in the
          aggregate, represent a fundamental change in the information set forth
          in the  registration  statement.  Notwithstanding  the foregoing,  any
          increase  or decrease  in volume of  securities  offered (if the total
          dollar  value of  securities  offered  would not exceed that which was
          registered)  and  any  deviation  from  the  low  or  high  end of the
          estimated  maximum  offering  range  may be  reflected  in the form of
          prospectus  filed with the  Commission  pursuant to Rule 424(b) if, in
          the aggregate,  the changes in volume and price represent no more than
          20 percent change in the maximum aggregate offering price set forth in
          the   "Calculation  of  Registration   Fee"  table  in  the  effective
          registration statement;

               (iii) to include any  material  information  with  respect to the
          plan of  distribution  not  previously  disclosed in the  registration
          statement  or  any  material   change  to  such   information  in  the
          registration statement;

provided,  however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
registration  statement  is on  Form  S-3,  Form  S-8,  or  Form  F-3,  and  the
information  required  to be  included in a  post-effective  amendment  by those
paragraphs  is  contained  in periodic  reports  filed with or  furnished to the
Commission by the  Registrant  pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934 that are  incorporated  by  reference  in the  registration
statement.

          (2)  That,  for the purpose of  determining  any  liability  under the
               Securities Act of 1933, each such post-effective  amendment shall
               be  deemed to be a new  registration  statement  relating  to the
               securities  offered therein,  and the offering of such securities
               at the time shall be deemed to be the initial bona fide  offering
               thereof.

          (3)  To  remove  from   registration  by  means  of  a  post-effective
               amendment any of the  securities  being  registered  which remain
               unsold at the termination of the offering.

     (b) The  undersigned  Registrant  hereby  undertakes  that, for purposes of
determining  any liability  under the Securities Act of 1933, each filing of the
Registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of  1934  that is  incorporated  by  reference  in the
registration  statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

     (c) Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors,  officers, and controlling persons of
the  Registrant  pursuant  to  the  foregoing  provisions,   or  otherwise,  the
Registrant  has been advised that in the opinion of the  Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore,  unenforceable. In the event that a claim for indemnification
against such  liabilities  (other than the payment by the Registrant of expenses
incurred or paid by a director, officer, or controlling person of the Registrant
in the  successful  defense of any action,  suit, or  proceeding) is asserted by
such director,  officer, or controlling person in connection with the securities
being registered,  the Registrant will, unless in the opinion of its counsel the
matter  has  been  settled  by  controlling  precedent,  submit  to a  court  of
appropriate  jurisdiction  the question  whether such  indemnification  by it is
against  public policy as expressed in the Act and will be governed by the final
adjudication of such issue.


                                      II-3

<PAGE>


                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of New York, State of New York, on December 3, 1998.

                                                  CELGENE CORPORATION

                                                  By:   /s/  John W. Jackson
                                                      --------------------------
 
                                                      John W. Jackson
                                                      Chairman of the Board and
                                                      Chief Executive Officer

                        SIGNATURES AND POWER OF ATTORNEY

     KNOW ALL MEN BY THESE  PRESENTS  that each person whose  signature  appears
below constitutes and appoints John W. Jackson and Sol J. Barer, Ph.D., and each
of them,  his true and lawful  attorney-in-fact  and  agent,  with full power of
substitution and  resubstitution,  to act, without the other, for him and in his
name,  place,  and  stead,  in any  and  all  capacities,  to  sign  any and all
amendments,  including post-effective amendments, to this registration statement
and to file  the  same,  with all  exhibits  thereto,  and  other  documents  in
connection therewith, with the Securities and Exchange Commission, granting unto
said  attorneys-in-fact  and agents full power and  authority  to do and perform
each and every act and thing requisite and necessary to be done in and about the
premises, as full to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that said  attorneys-in-fact  and agents, or
each of them,  their  substitute or  substitutes  may lawfully do or cause to be
done by virtue hereof.

     Pursuant to the  requirements  of the  Securities  Act of 1933, as amended,
this  Registration  Statement has been signed below by the following  persons in
the capacities and on the dates indicated.

Signatures                       Title                                   Date
                                
/s/  John W. Jackson             Chairman of the Board and      December 3, 1998
- -------------------------------  Chief Executive Officer
John W. Jackson                  (principal executive
                                 officer)
                                
/s/  Sol J. Barer, Ph.D.         President,                     December 3, 1998
- -------------------------------  Chief Operating Officer,
Sol J. Barer, Ph.D.              Acting Chief Financial Officer
                                 and Director (principal
                                 financial and accounting
                                 officer)
                                
/s/  James Swenson               Chief Accounting Officer       December 3, 1998
- -------------------------------
James Swenson
                                
/s/  Jack L. Bowman              Director                       December 3, 1998
- ------------------------------- 
Jack L. Bowman                  
                                
/s/  Frank T. Cary               Director                       December 3, 1998
- ------------------------------- 
Frank T. Cary                   
                                
/s/ Arthur Hull Hayes, Jr., M.   Director                       December 3, 1998
- ------------------------------- 
Arthur Hull Hayes, Jr., M.D.    
                               

                                      II-4

<PAGE>



   /s/ Gilla Kaplan, Ph.D.       Director                       December 3, 1998
- ------------------------------- 
Gilla Kaplan, Ph.D.

   /s/ Richard C.E. Morgan       Director                       December 3, 1998
- -------------------------------
Richard C.E. Morgan

   /s/ Walter L. Robb, Ph.D.     Director                       December 3, 1998
- -------------------------------
Walter L. Robb, Ph.D.

   /s/  Lee J. Schroeder        Director                        December 3, 1998
- -------------------------------
Lee J. Schroeder

                                      II-5

<PAGE>



                                  EXHIBIT INDEX
                                  -------------


         Exhibit                            Description of Exhibit

         4.1                     Celgene  Corporation  1998 Long-Term  Incentive
                                 Plan (incorporated by reference to Exhibit A to
                                 the Proxy  Statement of the  Registrant,  filed
                                 May 18, 1998)

         *5.1                    Opinion of Proskauer Rose LLP


         *23.1                   Consent of KPMG LLP


         *23.2                   Consent of Proskauer Rose LLP
                                   (included in Exhibit 5.1)


         *24.1                    Power of Attorney (included in
                                    page II-4 and II-5 hereof)
 





                                      II-6

<PAGE>



                                                                     EXHIBIT 5.1


                                                 December 29, 1998



Celgene Corporation
Powder Horn Drive
Warren, New Jersey 07059

Dear Sirs:

We are acting as counsel to Celgene  Corporation,  a Delaware  corporation  (the
"Company"),  in connection  with the filing of a Registration  Statement on Form
S-8 with exhibits  thereto (the  "Registration  Statement") by the Company under
the Securities Act of 1933 as amended, and the rules and regulations thereunder,
for  registration of up to 1,890,000  shares (the "Shares") of Common Stock, par
value $.01 per Share, of the Company. Of the Shares, (i) 1,500,000 Shares may be
issued by the Company  pursuant to the Company's 1998  Long-Term  Incentive Plan
(the  "Plan")  and (ii) an  aggregate  of  390,000  Shares  may be issued by the
Company pursuant to (a) a Stock Option Agreement dated August 2,1993 between the
Company and John L.  Ufheil (b) a Stock  Option  Agreement  dated March 21, 1994
between the Company and Richard G. Wright,  (c) a Stock Option  Agreement  dated
January 26, 1994  between the Company and Gilla  Kaplan,  and (d) a Stock Option
Agreement dated June 21, 1990 between the Company and Jack L. Ufheil  (together,
the "Option Agreements").

We have  participated in the preparation of the Registration  Statement and have
reviewed the corporate  proceedings in connection with the adoption of the Plan.
We have also  examined  and  relied  upon  originals  or  copies,  certified  or
otherwise authenticated to our satisfaction, of all such public officials and of
representatives  of the Company,  and have made such  investigation  of law, and
have discussed with  representatives  of the Company and such other persons such
questions of fact,  as we have deemed  proper and  necessary as a basis for this
opinion.

Based upon, and subject to, the foregoing, we are of the opinion that the Shares
are duly authorized and, upon issuance of the Shares in accordance with the Plan
and upon the exercise of the options issued  pursuant to the Option  Agreements,
will be,  assuming no change in the applicable law or pertinent  facts,  validly
issued, fully paid and non-assessable.

We  hereby  consent  to  the  filing  of  this  opinion  as  Exhibit  5.1 to the
Registration Statement. In giving the foregoing consent, we do not admit that we
are in the category of persons whose consent is required  under Section 7 of the
Securities  Act of 1933 or the  rules  and  regulations  of the  Securities  and
Exchange Commission promulgated thereunder.

Very truly yours,

/s/ Proskauer Rose LLP
Proskauer Rose LLP



                                      II-7
<PAGE>


                                                                    EXHIBIT 23.1






               CONSENT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS

To the Board of Directors of Celgene Corporation:

We  consent  to the  incorporation  herein  by  reference  in this  Registration
Statement of Celgene  Corporation  on Form S-8 of our report dated  February 13,
1998,  relating to the balance sheets of Celgene  Corporation as of December 31,
1996 and 1997, and the related statements of operations,  stockholders'  equity,
and cash flows for each of the years in the three-year period ended December 31,
1997,  which  report  appears  in the  Annual  Report  on Form  10-K of  Celgene
Corporation for the year ended December 31, 1997.


                                               KPMG LLP

Short Hills, NJ
January 4, 1999

                                      II-8

<PAGE>





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