CELGENE CORP /DE/
DEF 14A, 2000-05-05
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                  SCHEDULE 14A
                                 (RULE 14A-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

          PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                             EXCHANGE ACT OF 1934
 [X] Filed by the  Registrant [ ] Filed by a Party other than the Registrant [ ]
 Check the appropriate box:
 [ ] Preliminary Proxy Statement            [ ]Confidential, For Use of the Com-
                                               mission Only (as permitted by
                                               Rule 14a-6(e)(2))
 [X] Definitive Proxy Statement
 [ ] Definitive Additional Materials
 [ ] Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                               CELGENE CORPORATION
- --------------------------------------------------------------------------------
               (Name of Registrant as Specified in Its Charter)

- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant

Payment of Filing Fee (Check the appropriate box): [X] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11. (1)
Title of each class of securities to which transaction applies:
- --------------------------------------------------------------------------------
(2) Aggregate number of securities to which transaction applies:
- --------------------------------------------------------------------------------
(3) Per unit price or other underlying value of transaction computed pursuant to
Exchange  Act Rule  0-11  (set  forth the  amount  on which  the  filing  fee is
calculated and state how it was determined):
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(4) Proposed maximum aggregate value of transaction:
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(5) Total fee paid:
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 [ ] Fee paid previously with preliminary materials:
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 [ ] Check box if any part of the fee is offset as provided by Exchange Act Rule
0-11(a)(2)  and  identify  the  filing  for  which the  offsetting  fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.
(1) Amount previously paid:
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(2) Form, Schedule or Registration Statement no.:
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(3) Filing Party:
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(4) Date Filed:
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<PAGE>

                               CELGENE CORPORATION
                               7 POWDER HORN DRIVE
                           WARREN, NEW JERSEY 07059

                                   May 8, 2000

Dear Stockholder:

     On behalf of the Board of Directors,  I cordially  invite you to attend the
2000 Annual Meeting of Stockholders of Celgene  Corporation.  The Annual Meeting
will be held on Tuesday,  June 20, 2000,  beginning at 1:00 p.m., local time, at
the offices of Proskauer Rose LLP, 1585 Broadway, 26th floor, New York, New York
10036.  The  formal  Notice  of  Annual  Meeting  is set  forth in the  enclosed
material.

     The matters  expected to be acted upon at the meeting are  described in the
attached  Proxy  Statement.  During  the  meeting,  stockholders  will  have the
opportunity to ask questions and comment on the Company's operation.

     It is important that your views be represented  whether or not you are able
to be present at the Annual  Meeting.  Please sign and return the enclosed proxy
card promptly.

     We appreciate your investment in Celgene Corporation and urge you to return
your proxy card as soon as possible.

                                                  Sincerely,

                                                  John W. Jackson
                                                  Chairman of the Board and
                                                  Chief Executive Officer
<PAGE>

                               CELGENE CORPORATION
                               7 POWDER HORN DRIVE
                            WARREN, NEW JERSEY 07059


                          --------------------------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                          --------------------------

     The Annual Meeting of Stockholders of CELGENE  CORPORATION  (the "Company")
will be held at the offices of Proskauer  Rose LLP, 1585  Broadway,  26th floor,
New York,  New York 10036 on June 20, 2000,  at 1:00 p.m.,  local time,  for the
following purposes:

     1.   to elect nine directors;

     2.   to amend the 1998 Long-Term Incentive Plan (the "1998 Incentive Plan")
          to  increase  the  number  of  shares  that may be  subject  to awards
          thereunder from 4,500,000 to 6,500,000;

     3.   to ratify the  appointment  of KPMG LLP as the  independent  certified
          public  accountants of the Company for the fiscal year ending December
          31, 2000; and

     4.   to transact any such other  business as may  properly  come before the
          Meeting and at any adjournment thereof.

     The Board of  Directors  has fixed the close of  business on May 1, 2000 as
the record date for determining  stockholders  entitled to notice of and to vote
at the meeting.

    A proxy and return envelope are enclosed for your convenience.

                                        By order of the Board of Directors
                                        JOHN W. JACKSON
                                        Chairman of the Board and
                                        Chief Executive Officer

May 8, 2000

                             YOUR VOTE IS IMPORTANT
                   Please mark, sign, and date the enclosed
                       proxy card and return it promptly
               in the enclosed self-addressed, stamped envelope.
<PAGE>

                               CELGENE CORPORATION
                               7 POWDER HORN DRIVE
                           WARREN, NEW JERSEY 07059

                              ---------------------
                                 PROXY STATEMENT
                              ---------------------

     This  Proxy   Statement  is  furnished  to  the   stockholders  of  Celgene
Corporation,  a Delaware  corporation  (the  "Company"),  in connection with the
solicitation  of proxies by the Board of Directors for use at the Annual Meeting
of Stockholders (the "Meeting" or "Annual Meeting") of the Company to be held on
June 20, 2000, and at any adjournment  thereof.  A copy of the notice of meeting
accompanies  this Proxy  Statement.  It is anticipated  that the mailing of this
Proxy Statement will commence on or about May 8, 2000.


     Only  stockholders  of record at the close of business on May 1, 2000,  the
record date for the Annual Meeting, will be entitled to notice of and to vote at
the Meeting. On the record date the Company had outstanding 64,415,089 shares of
common stock, par value $.01 per share (the "Common Stock"),  which are the only
securities  of the Company  entitled to vote at the Annual  Meeting,  each share
being entitled to one vote.

     Stockholders  who execute  proxies may revoke them by giving written notice
to the Chief  Executive  Officer of the Company at any time before such  proxies
are voted.  Attendance  at the  Meeting  shall not have the effect of revoking a
proxy unless the  stockholder  so  attending  shall,  in writing,  so notify the
Secretary of the Meeting at any time prior to the voting of the proxy.

     The Board of  Directors  does not know of any matter that is expected to be
presented  for  consideration  at  the  Meeting,  other  than  the  election  of
directors,  the amendment to the 1998 Incentive Plan and the confirmation of the
appointment of the independent  certified public  accountants of the Company for
the current  fiscal year.  However,  if other  matters  properly come before the
Meeting,  the persons named in the accompanying  proxy intend to vote thereon in
accordance with their judgment.

     The Company  will bear the cost of the  Meeting and the cost of  soliciting
proxies,  including  the cost of mailing  the proxy  material.  In  addition  to
solicitation by mail, directors,  officers, and regular employees of the Company
(who will not be specifically compensated for such services) may solicit proxies
by telephone or otherwise.  Arrangements  will be made with brokerage houses and
other  custodians,  nominees,  and  fiduciaries  to  forward  proxies  and proxy
material to their  principals,  and the Company  will  reimburse  them for their
expenses.

     All proxies received  pursuant to this solicitation will be voted except as
to matters where authority to vote is specifically  withheld and, where a choice
is  specified as to the  proposal,  they will be voted in  accordance  with such
specification.  If no  instructions  are given,  the persons  named in the proxy
solicited  by the  Board of  Directors  of the  Company  intend  to vote FOR the
nominees  for  election as  directors  of the  Company  listed  herein,  FOR the
amendment of the 1998 Incentive Plan and FOR the ratification of the appointment
of KPMG LLP as the Company's  independent  certified public  accountants for the
fiscal year ending December 31, 2000.


     A majority of the  outstanding  shares of Common Stock  entitled to vote on
the  record  date,  whether  present  in person or  represented  by proxy,  will
constitute a quorum for the  transaction  of business at the Annual  Meeting and
any adjournment or postponement  thereof.  Abstentions and broker non-votes will
be counted as present or represented  for purposes of  establishing a quorum for
the transaction of business.

<PAGE>

     Abstentions  are  counted in  tabulations  of the votes  cast on  proposals
presented to stockholders, whereas broker non-votes are not counted for purposes
of  determining  whether a proposal has been  approved.  Abstentions  and broker
non-votes  will  have no  effect  on the  election  of  directors,  which  is by
plurality  vote,  but  abstentions   will,  in  effect,  be  votes  against  the
ratification of the selection of independent public accountants, and approval of
the proposed  amendment to the 1998  Incentive  Plan, as these items require the
affirmative  vote of the shares of Common Stock  present and eligible to vote on
such matters.

     All shares of Common Stock as set forth in this proxy  statement  have been
adjusted to reflect the three for one split  declared by the Company and paid on
April 14, 2000 (the "Split").

                   MATTERS TO COME BEFORE THE ANNUAL MEETING
                       PROPOSAL ONE: ELECTION OF DIRECTORS

     At the Annual  Meeting,  nine  directors  are to be  elected,  each to hold
office  (subject to the  Company's  By-Laws)  until the next annual  meeting and
until his or her  successor  has been  elected  and  qualified.  Pursuant to the
Company's  By-Laws,  the Board of Directors has fixed the number of directors at
nine.  Each  nominee  has  consented  to being  named as a nominee in this Proxy
Statement  and to serve if  elected.  If any  nominee  listed in the table below
should become unavailable for any reason,  which the Board of Directors does not
anticipate,  the proxy will be voted for any substitute  nominee or nominees who
may be selected by the Board of Directors prior to or at the Meeting,  or, if no
substitute is selected by the Board of Directors prior to or at the Meeting, for
a motion to reduce the  membership  of the Board of  Directors  to the number of
nominees  available.  Directors  will be  elected  by an  affirmative  vote of a
plurality  of the  votes  cast  at  the  Annual  Meeting.  There  are no  family
relationships  between  any of  the  directors  and  executive  officers  of the
Company. The information concerning the nominees and their security holdings has
been furnished by them to the Company.

<TABLE>
<CAPTION>
                  NAME                   AGE                   POSITION
- --------------------------------------- ----- ------------------------------------------
<S>                                     <C>   <C>
John W. Jackson .......................  55   Chairman of the Board and Chief Executive
                                              Officer
Sol J. Barer, Ph.D. ...................  52   President, Chief Operating Officer and
                                              Director
Jack L. Bowman ........................  67   Director
Frank T. Cary .........................  79   Director
Arthur Hull Hayes, Jr., M.D. ..........  66   Director
Gilla Kaplan, Ph.D. ...................  52   Director
Richard C.E. Morgan ...................  55   Director
Walter L. Robb, Ph.D. .................  72   Director
Lee J. Schroeder ......................  71   Director
</TABLE>

     John W.  Jackson  has been our  Chairman  of the Board and Chief  Executive
Officer since January 1996.  From February 1991 to January 1996, Mr. Jackson was
President  of  Gemini  Medical,  a  consulting  firm that he  founded  and which
specialized  in services and  investment  advice to start-up  medical device and
biotechnology  companies.  Previously,  Mr.  Jackson had been  President  of the
worldwide Medical Device Division of American Cyanamid,  a major  pharmaceutical
company, from February 1986 to January 1991, and served in various international
positions,  including Vice President -- International for American Cyanamid from
1978 to 1986. Mr. Jackson served in several human health marketing  positions at
Merck & Company, a major pharmaceutical  company, from 1971 to 1978. Mr. Jackson
received a B.A. degree from Yale University and an M.B.A.  from INSEAD,  France.


                                        2
<PAGE>

     Sol J. Barer,  Ph.D.  has been our  President of the Company  since October
1993 and our Chief Operating  Officer and one of our directors since March 1994.
Dr.  Barer  was  Senior  Vice  President  --  Science  and  Technology  and Vice
President/General  Manager -- Chiral  Products from October 1990 to October 1993
and our Vice  President -- Technology  from  September 1987 to October 1990. Dr.
Barer  received  a  Ph.D.  in  organic  and  physical   chemistry  from  Rutgers
University.

     Jack L. Bowman,  one of our directors  since April 1998,  served as Company
Group  Chairman of Johnson & Johnson from 1987 to 1994.  From 1983 to 1987,  Mr.
Bowman served as Executive  Vice President of American  Cyanamid.  Mr. Bowman is
also  a  director  of  NeoRx  Corporation,  Cell  Therapeutics,   Inc.,  Cellegy
Pharmaceuticals, Targeted Genetics and Osiris Phamaceuticals.

     Frank T. Cary has been Chairman of the Executive  Committee of our Board of
Directors  since July 1990 and has been one of our  directors  since 1987.  From
1973 to 1981, Mr. Cary was Chairman of the Board and Chief Executive  Officer of
International  Business  Machines  Corporation.  Mr.  Cary also is a director of
Cygnus  Therapeutic  Systems  Inc.,  ICOS  Corporation,  Lincare  Inc.,  Lexmark
International Inc., Vion Pharmaceuticals Inc. and Teltrend, Inc.

     Arthur  Hull  Hayes,  Jr.,  M.D., one of our directors since 1995, has been
President  and  Chief  Operating  Officer  of  MediScience  Associates,  Inc., a
consulting   organization  that  works  with  pharmaceutical  firms,  biomedical
companies  and  foreign  governments, since July 1991. Dr. Hayes has also been a
partner  in  Issue  Sphere, a public affairs firm that focuses on health science
issues,  since  November  1995, as well as a professor in medicine, pharmacology
and  family  and  community  medicine  at  New York Medical College and clinical
professor  of  medicine  and  pharmacology  at the Pennsylvania State University
College  of  Medicine.  From  1986  to  1990,  Dr. Hayes was President and Chief
Executive  Officer  of E.M. Pharmaceuticals, a unit of E. Merck AG and from 1981
to  1983 was Commissioner of the United States Food and Drug Administration. Dr.
Hayes  also  is a director of Myriad Genetics, Inc., NaPro BioTherapeutics, Inc.
and Premier Research Worldwide.

     Gilla  Kaplan,  Ph.D.,  one  of  our  directors  since  April  1998,  is an
immunologist  in the  Laboratory of Cellular  Physiology  and  Immunology at The
Rockefeller  University in New York where she was appointed  Assistant Professor
in 1985 and  Associate  Professor  in 1990.  Dr.  Kaplan is a member of numerous
professional  societies and has been the organizer of several major  symposia on
tuberculosis.  Dr.  Kaplan has served as an  advisor to the Global  Program  for
Vaccines and Immunization of the World Health Organization,  has participated in
several NIH peer review panels,  and is on the Editorial Board of Microbial Drug
Resistances and Tubercle and Lung Disease. Dr. Kaplan is the author of more than
100 scientific  publications and has received international  recognition for her
work. In 1995, she gave the Special Honorary Lecture at the American Society for
Microbiology  and in 1997 was  appointed  a Fellow of the  American  Academy  of
Microbiology.

     Richard C.E.  Morgan,  one of our directors since 1987, is the Chairman and
Chief  Executive  Officer  of  incuVest  LLC and a  Managing  Partner of Amphion
Partners LLC, formerly Wolfensohn  Partners,  L.P. Mr. Morgan is Chairman of the
Board of Directors  of Quidel Corp.  He also serves on the Board of Directors of
Indigo, N.V., ChromaVision Medical Systems, Inc., and Orbis International, Inc.

     Walter L. Robb,  Ph.D., one of our directors since 1992, has been a private
consultant and President of Vantage  Management  Inc., a consulting and investor
services  company,  since January 1993.  Mr. Robb was Senior Vice  President for
Corporate Research and Development of General Electric Company,  and a member of
its Corporate Executive Council from 1986 to December 1992. Mr. Robb is Chairman
of the Board of Directors of Capital District  Sports.  He is also a director of
Cree,  Inc.,   Mechanical   Technology,   Inc.,  Plug  Power,  Inc.,   Molecular
OptoElectronics, Nextec, R2 Technology, and X-Ray Optical Systems.


                                        3
<PAGE>

     Lee  J.  Schroeder,  one of our directors since 1995, has been President of
Lee  Schroeder  &  Associates,  Inc., pharmaceutical business consultants, since
1985.  Mr.  Schroeder  was President of Fox Meyer Lincoln from 1983 to 1985, and
was  an  Executive  Vice  President  of  Sandoz,  Inc.  from  1981  to 1983. Mr.
Schroeder  also  is  a  director of MGI Pharmaceutical, Inc., Ascent Pediatrics,
Inc. and Interneuron Pharmaceuticals, Inc.

                          --------------------------

     The  Company's  By-Laws  provide  that  nominations  for  the  election  of
directors may be made at any annual  meeting of the  stockholders:  (a) by or at
the  direction  of the  Board of  Directors  (or any duly  authorized  committee
thereof) or (b) by any  stockholder  of the Company (i) who is a stockholder  of
record on the date of the giving of the  notice  and on the record  date for the
determination  of stockholders  entitled to vote at such annual meeting and (ii)
who complies with the notice procedures set forth below.

     In addition to any other  applicable  requirements,  for a nomination to be
made by a stockholder, such stockholder must have given timely notice thereof in
proper written form to the Secretary of the Company.

     To be timely, a stockholder's  notice to the Secretary must be delivered to
or mailed and  received at the  principal  executive  offices of the Company not
less than  sixty (60) days nor more than  ninety  (90) days prior to the date of
the annual meeting; provided,  however, that in the event that less than seventy
(70) days' notice or prior public  disclosure of the date of the annual  meeting
is given or made to  stockholders,  notice  by the  stockholder  (in order to be
timely)  must be so  received  not later than the close of business on the tenth
(10th)  day  following  the day on which  such  notice of the date of the annual
meeting was mailed or such public  disclosure of the date of the annual  meeting
was made, whichever first occurs.

     To be in proper written form, a stockholder's  notice to the Secretary must
set forth (a) as to each person whom the  stockholder  proposes to nominate  for
election as a director (i) the name, age, business address and residence address
of theperson,  (ii) the principal  occupation or employment of the person, (iii)
the class or series and number of shares of capital  stock of the Company  which
are owned beneficially or of record by the person and (iv) any other information
relating  to the  person  that  would be  required  to be  disclosed  in a proxy
statement or other filing required to be made in connection  with  solicitations
of proxies for  election of directors  pursuant to Section 14 of the  Securities
Exchange  Act of 1934,  as  amended  (the  "Exchange  Act"),  and the  rules and
regulations  promulgated  thereunder;  and (b) as to the stockholder  giving the
notice (i) the name and record  address of such  stockholder,  (ii) the class or
series  and  number of shares of capital  stock of the  Company  which are owned
beneficially  or of  record  by such  stockholder,  (iii) a  description  of all
arrangements  or  understandings  between  such  stockholder  and each  proposed
nominee and any other  person or persons  (including  their  names)  pursuant to
which  the  nomination(s)   are  to  be  made  by  such   stockholder,   (iv)  a
representation  that such stockholder intends to appear in person or by proxy at
the annual meeting to nominate the persons named in his notice and (v) any other
information  relating to such stockholder that would be required to be disclosed
in a proxy  statement or other  filing  required to be made in  connection  with
solicitations of proxies for election of directors pursuant to Section 14 of the
Exchange Act and the rules and regulations promulgated  thereunder.  Such notice
must be accompanied by a written consent of each proposed nominee to being named
as a nominee and to serve as a director if elected.

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The table below sets forth the beneficial  ownership of the Common Stock as
of March 31,  2000 (i) by each  director,  (ii) by each of the  named  executive
officers  (iii) by all  directors  and  executive  officers  of the Company as a
group,  and (iv) by all persons known by the Board of Directors to be beneficial
owners of more than five percent of the outstanding  shares of Common Stock. All
shares of Common Stock have been adjusted to reflect the Split.


                                        4
<PAGE>
<TABLE>
<CAPTION>
                                                       AMOUNT AND NATURE OF     PERCENT OF
                        NAME                           BENEFICIAL OWNERSHIP       CLASS
- ---------------------------------------------------   ----------------------   -----------
<S>                                                   <C>                      <C>
John W. Jackson ...................................         1,164,399(1)            1.8%
Sol J. Barer, Ph.D. ...............................           697,284(1)(2)         1.1%
Robert J. Hugin ...................................            35,000(1)              *
Frank T. Carey ....................................           293,340                 *
Arthur Hull Hayes, Jr., M.D. ......................           120,000(1)              *
Richard C.E. Morgan ...............................           237,270(1)(3)           *
Walter L. Robb, Ph.D. .............................           300,000(1)              *
Lee J. Schroeder ..................................           168,000(1)              *
Gilla Kaplan ......................................            50,100(1)              *
Jack L. Bowman ....................................            38,100(1)              *
All directors and current executive officers of the
Company as a group (ten persons) ..................         3,103,493(4)            4.8%
Pilgram Baxter & Associates, Ltd. .................
825 Duportail Road
Wayne, PA 19087                                             3,361,200(5)            5.2%
</TABLE>

- -------------
 * Less than one percent (1%).

(1)  Includes shares of Common Stock which the directors and executive  officers
     have the right to acquire through the exercise of options within 60 days of
     March 31, 2000,  as follows:  John W.  Jackson -- 981,369;  Sol J. Barer --
     697,239;  Robert J. Hugin -- 35,000; Frank T. Cary -- 0; Arthur Hull Hayes,
     Jr. -- 120,000;  Richard C.E.  Morgan -- 75,000  shares;  Walter L. Robb --
     192,000; Lee J. Schroeder -- 60,000; Gilla Kaplan -- 50,100; Jack Bowman --
     35,100.  Does not include  shares of Common Stock which the  directors  and
     executive officers had the right to acquire through the exercise of options
     not  exercisable  within 60 days of March 31,  2000,  as  follows:  John W.
     Jackson -- 740,001;  Sol J. Barer --  290,001;  Robert J. Hugin -- 520,000;
     Frank T. Cary -- 30,000;  Arthur Hull Hayes,  Jr. -- 30,000;  Richard  C.E.
     Morgan -- 30,000;  Walter L. Robb -- 30,000;  Lee J.  Schroeder  -- 30,000;
     Gilla Kaplan -- 60,000; and Jack L. Bowman -- 60,000.

(2)  Includes with respect to Dr. Barer,  45 shares owned by the daughter of Dr.
     Barer, as to which shares Dr. Barer disclaims beneficial ownership.

(3)  Includes  with  respect to Mr.  Morgan,  270 shares owned by the son of Mr.
     Morgan, as to which shares Mr. Morgan disclaims beneficial ownership.

(4)  Includes  or  excludes,  as the  case may be,  shares  of  Common  Stock as
     indicated in the preceding footnotes.

(5)  Information  regarding  Pilgrim  Baxter & Associates  was  obtained  from a
     questionnaire  and from a Schedule 13G, filed by it with the Securities and
     Exchange  Commission.  Such  Schedule  13G  states  that  Pilgrim  Baxter &
     Associates  Ltd. is the  beneficial  owner of and has the sole  dispositive
     power over all such shares of Common  Stock and has sole voting  power over
     2,557,500 of those shares.

DIRECTOR COMPENSATION

     Directors do not receive salaries or cash fees for serving as directors nor
do they receive any cash  compensation for serving on committees;  however,  all
members of the Board of Directors who are not


                                        5
<PAGE>

employees of the Company  ("Non-Employee  Directors")  are  reimbursed for their
expenses for each meeting  attended  and are eligible to receive  stock  options
pursuant to the 1995 Non-Employee Directors' Option Plan (the "Directors' Option
Plan").

     The  Directors'  Option Plan was adopted by the Board of Directors on April
5, 1995, and approved by the Company's  stockholders  at the 1995 Annual Meeting
of  Stockholders.  At the  Annual  Meeting  of the  Company  held in  1997,  the
Director's  Option  Plan was  amended  to  increase  the number of shares of the
Company's  Common  Stock that may be issued  upon  exercise  of options  granted
thereunder  from 750,000 shares to 1,050,000,  as adjusted for the Split. At the
Annual  Meeting of the  Company  held in 1999,  the  Directors'  Option Plan was
amended to increase the number of shares of the Company's  Common Stock that may
be issued upon exercise of options granted  thereunder from 1,050,000  shares to
1,800,000  shares,  as  adjusted  for the  Split.  The  Directors'  Option  Plan
currently  provides for the granting to Non-Employee  Directors of non-qualified
options to purchase an aggregate of not more than 1,800,000  shares  (subject to
adjustment in certain circumstances) of Common Stock.

     Under the Directors' Option Plan, each Non-Employee Director as of April 5,
1995 was  granted a  non-qualified  option to purchase  60,000  shares of Common
Stock,  as adjusted for the Split, and each new  Non-Employee Director  upon the
date of his or her  election  or  appointment  will be  granted a  non-qualified
option to purchase 20,000 shares of Common Stock.  These initial options vest in
four equal annual  installments  commencing on the first anniversary of the date
of grant, assuming the Non-Employee Director remains a director.

     Upon the date of each Annual  Meeting of  Stockholders,  each  Non-Employee
Director is granted a  non-qualified  option to purchase 60,000 shares of Common
Stock (or a pro rata  portion  thereof if the  director did not serve the entire
year since the date of the last annual  meeting).  These options vest in full on
the date of the first Annual Meeting of Stockholders  held following the date of
the grant, assuming the Non-Employer Director is a director on that date.

     All options granted  pursuant to the Directors'  Option Plan will expire no
later than 10 years from the date of grant and no options  may be granted  after
June 16, 2005. If a Non-Employee Director terminates his service on the Board of
Directors  for  any  reason,  options  which  were  exercisable  on the  date of
termination  and which have not expired may be  exercised  at any time until the
date of expiration of such options. In addition, if there is a change of control
and within two years thereafter a director is removed without cause (as defined)
or is not  nominated for election by the  Company's  stockholders,  all unvested
portions of a stock option will automatically vest.

     In 1999,  pursuant to the Directors'  Option Plan, each of Messrs.  Bowman,
Cary,  Hayes,  Morgan,  Robb,  Schroeder  and Dr.  Kaplan  received an option to
purchase  30,000  shares of Common  Stock at an  exercise  price of $5.2083  per
share,  the fair market value of the stock on the date of the grant, as adjusted
for the Split.

BOARD COMMITTEES AND MEMBERSHIP

     The  Company  has  an  Executive Committee of the Board of Directors, whose
current  members  are Frank T. Cary, Chairman, Sol J. Barer, John W. Jackson and
Richard  C.  E.  Morgan.  The  Executive Committee held one meeting in 1999. The
Executive  Committee has and may exercise all of the powers and authority of the
full Board of Directors of the Company, subject to certain exceptions.

     The Company has an Audit  Committee of the Board of  Directors,  consisting
entirely of outside directors,  the current members of which are Walter L. Robb,
Chairman,  Arthur Hull Hayes,  Jr., M.D., and Gilla Kaplan.  The Audit Committee
held one meeting in 1999. The Board of Directors


                                        6
<PAGE>

has delegated to the Audit  Committee the following  duties:  reviewing with the
independent  auditors the plans and results of the audit  engagement;  reviewing
the  adequacy,  scope,  and  results of the  internal  accounting  controls  and
procedures;  reviewing the degree of independence of the auditors; reviewing the
auditors' fees; and recommending the engagement of auditors to the full Board of
Directors.

     The Company has a Management  Compensation  and Development  Committee (the
"Compensation  Committee") of the Board of Directors,  whose current members are
Richard  C.E.  Morgan,  Chairman,  Frank  T.  Cary,  Jack L.  Bowman  and Lee J.
Schroeder.   The  Compensation  Committee  held  three  meetings  in  1999.  The
Compensation  Committee  has (i) the full power and  authority to interpret  the
provisions and supervise the  administration  of the Company's 1986 Stock Option
Plan, 1992 Long-Term Incentive Plan and the 1998 Long-Term Incentive Plan and to
grant  options  outside  of these  plans and (ii) the  authority  to review  all
matters relating to the personnel of the Company.

     The Company  does not have a nominating  committee.  The Board of Directors
held five meetings during 1999. During 1999, all of the directors  attended more
than 75% of the  aggregate  of (i) the total  number of meetings of the Board of
Directors  and (ii) the total number of meetings of all  committees of the Board
on which such director served.

COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT OF 1934

     Under the securities  laws of the United States,  the Company's  directors,
executive  officers  and any persons  holding more than 10 percent of the Common
Stock are required to report their  ownership of Common Stock and any changes in
that ownership,  on a timely basis,  to the Securities and Exchange  Commission.
Due  to  an  administrative  oversight,   Messrs.  Cary,  Hayes,  Morgan,  Robb,
Schroeder,  Bowman and Dr.  Kaplan were not able to timely  file forms  required
with respect to the  automatic  grant of options in 1999 under the  Non-Employee
Directors' Incentive Plan and Messrs.  Jackson, Barer and Hugin were not able to
timely file forms with respect to options  granted in 1999 to each of them under
the Company's 1998 Long-Term Incentive Plan.

RECOMMENDATION OF THE BOARD OF DIRECTORS

             THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE
                   FOR THE ELECTION OF EACH OF THE NOMINEES


                                        7
<PAGE>

                 EXECUTIVE COMPENSATION AND OTHER INFORMATION

SUMMARY OF CASH AND CERTAIN OTHER COMPENSATION

     The following table sets forth information about the compensation  paid, or
payable,  by the Company for services  rendered in all  capacities  to the Chief
Executive  Officer of the Company  and each of the most  highly  paid  executive
officers of the Company  who earned more than  $100,000,  for each of the fiscal
years ended December 31, 1999,  December 31, 1998 and December 31, 1997 in which
such officers were executive officers for all or part of the year.

<TABLE>
<CAPTION>
                                                        ANNUAL
                                                     COMPENSATION
                                      -------------------------------------------
           NAME AND                                               OTHER ANNUAL
      PRINCIPAL POSITION        YEAR   SALARY ($)   BONUS ($)   COMPENSATION ($)
- ------------------------------ ------ ------------ ----------- ------------------
<S>                            <C>    <C>          <C>         <C>
John W. Jackson .............. 1999     300,000      390,000         19,200(1)
 Chairman and Chief            1998     285,000       79,800         19,200(1)
 Executive Officer             1997     270,000       97,200          9,500(1)

Sol J. Barer, Ph.D. .......... 1999     255,833      230,250         19,200(1)
 President and Chief           1998     243,333       51,100         19,200(1)
 Operating Officer             1997     232,500       63,647          9,500(1)

Robert J. Hugin(3) ........... 1999     127,385      168,000          7,200(1)
 Senior Vice President and
 Chief Financial Officer

<CAPTION>
                                                   LONG TERM
                                                 COMPENSATION
                               -------------------------------------------------
                                                   SECURITIES
           NAME AND             RESTRICTED STOCK   UNDERLYING      ALL OTHER
      PRINCIPAL POSITION          AWARD(S) ($)      OPTIONS #   COMPENSATION ($)
- ------------------------------ ------------------ ------------ -----------------
<S>                            <C>                <C>          <C>
John W. Jackson ..............         0             660,000         13,390(2)
 Chairman and Chief                    0             300,000         13,390(2)
 Executive Officer                     0                   0         13,390(2)

Sol J. Barer, Ph.D. ..........         0             210,000              0
 President and Chief                   0             150,000              0
 Operating Officer                     0                   0              0

Robert J. Hugin(3) ...........         0             450,000              0
 Senior Vice President and
 Chief Financial Officer

</TABLE>

- -------------

(1)  Reflects matching contributions under the Company's 401k plan.

(2)  Reflects  life  insurance  premiums  for a life  insurance  policy  for Mr.
     Jackson.

(3)  Mr. Hugin has been employed by the Company since June 1999.

EMPLOYMENT AGREEMENTS AND TERMINATION OF EMPLOYMENT ARRANGEMENTS

     John W. Jackson, Sol J. Barer and Robert J. Hugin (each an "Executive") are
employed pursuant to substantially similar employment agreements  (collectively,
the  "Employment  Agreements")  providing for their continued  employment  until
January 1, 2003 (the period during which Executive is employed is referred to as
the "Employment  Period").  The Employment Period shall be automatically renewed
for  successive  one-year  terms unless the Company or Executive  gives  written
notice  to the  other  at  least  six  months  prior  to the  expiration  of the
Employment Period. The Employment Agreements provide Messrs.  Jackson, Barer and
Hugin with a base salary (which may be increased by the Board of Directors, or a
committee thereof) of $300,000, $258,000 and $240,000,  respectively, per annum.
In addition,  each of the  Employment  Agreements  provides for an annual target
bonus in such amount equal to 65%,  45% and 35%,  respectively,  of  Executive's
base salary measured against objective criteria to be determined by the Board of
Directors,  or a committee thereof. The Employment  Agreements also provide that
Messrs.  Jackson, Barer and Hugin are entitled to continue to participate in all
group health and insurance  programs and all other fringe  benefit or retirement
plans which are  generally  available to the  Company's  employees.  Each of the
Employment  Agreements  provides  that if the  Executive  is  terminated  by the
Company  without cause or due to  disability,  he shall be entitled to receive a
lump-sum payment in an amount equal to Executive's  annual base salary and a pro
rata share of Executive's  annual target bonus.  Upon the occurrence of a change
in control  (as  defined in the  Employment  Agreements)  and  thereafter,  each
Employment  Agreement also provides that if (a) at any time within one year of a
change in control  Executive's  employment is terminated by the Company  without


                                       8
<PAGE>

cause or for  disability  or by  Executive  for good  reason (as  defined in the
Employment  Agreement)  or (b) at any time  within 90 days  prior to a change in
control, Executive's employment is terminated by the Company without cause or by
Executive for good reason,  Executive  shall be entitled to receive:  (i) a lump
sum payment in an amount equal to three times  Executive's base salary and three
times  Executive's  highest  annual  bonus  within the three  years prior to the
change in  control;  (ii) any  accrued  benefits;  (iii)  payment  of health and
welfare  premiums for Executive and his dependants;  and (iv) full and immediate
vesting of all stock options and equity  awards;  provided,  however,  that such
payment shall be reduced by any payments  made to Executive  prior to the change
in control pursuant to Sections 10(a)(iv) and (v) of the Employment  Agreements.
Each  Employment  Agreement  also provides that  Executive  shall be entitled to
receive a gross-up payment on any payments made to Executive that are subject to
the excise tax imposed by Section 4999 of the Internal Revenue Code, except that
a gross-up will not be made if the payments made to Executive do not exceed 105%
of the greatest  amount that could be paid to Executive such that the receipt of
payments  would not give rise to the excise tax. Each  Executive is subject to a
non-compete  which applies during the period the Executive is employed and until
the  first  anniversary  of the  date  Executive's  employment  terminates  (the
non-compete applies to the second anniversary of the date Executive's employment
terminates if the Executive receives change in control payments and benefits).

STOCK OPTIONS

     The following table sets forth  information for each of the named executive
officers  with respect to the value of options  exercised  during the year ended
December 31, 1999, and the value of outstanding and unexercised  options held as
of December 31, 1999. There were no stock  appreciation  rights exercised during
1999 and none were outstanding as of December 31, 1999.

OPTION GRANTS FOR FISCAL 1999

     The following table provides information concerning grants of stock options
by the Company to the named  executive  officers in fiscal 1999 as adjusted  for
the Split.

                       OPTION GRANTS DURING FISCAL 1999

<TABLE>
<CAPTION>
                                                                                              POTENTIAL REALIZABLE VALUE
                                                                                                         AT
                                                                                                ASSUMED ANNUAL RATES OF
                                         NUMBER OF     % OF TOTAL                                        STOCK
                                         SECURITIES      OPTIONS                                PRICE APPRECIATION FOR
                                         UNDERLYING      GRANTED       EXERCISE                       OPTION TERM
                                          OPTIONS     TO EMPLOYEES    PRICE PER    EXPIRATION --------------------------
         NAME           DATE OF GRANT   GRANTED (1)    IN 1999 (2)      SHARE         DATE         5%           10%
- ---------------------- --------------- ------------- -------------- ------------- ----------- ------------ ------------
<S>                    <C>             <C>           <C>            <C>           <C>         <C>          <C>
John W. Jackson ......    1/22/99         210,000           8%      $ 5.5000        1/22/09      577,500    1,155,000
                          4/20/99         450,000          18%      $ 6.0000        4/20/09    1,350,000    2,700,000

Sol J. Barer .........    1/22/99         105,000           4%      $ 5.5000        1/22/09      288,750      577,500
                          4/20/99         105,000           4%      $ 6.0000        4/20/09      315,000      630,000

Robert J. Hugin ......    6/22/99         450,000          18%      $ 5.2083        6/22/09    1,171,875    2,343,750
</TABLE>

- -------------
(1)  All options  granted in 1999 were granted  pursuant to the  Company's  1998
     Long-Term  Incentive  Plan.  The grants to Mr.  Jackson,  Dr. Barer and Mr.
     Hugin are exercisable in annual  increments of 33 1/3% of each total grant,
     beginning on the first  anniversary of the date of grant.  All options were
     granted at the fair market value of Common Stock on the  effective  date of
     grant, as adjusted for the Split.

(2)  The total number of options granted to employees in 1999 was 2,445,591.


                                       9
<PAGE>

OPTION EXERCISES AND VALUES FOR FISCAL 1999

The following table provides information  concerning options exercised in fiscal
1999 by the named executive  officers,  as adjusted for the Split, and the value
of such officers' unexercised options at December 31, 1999.

                AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR-END OPTION VALUES

<TABLE>
<CAPTION>
                                                                        NUMBER OF
                                                                  SECURITIES UNDERLYING       VALUE OF UNEXERCISED
                                                                   UNEXERCISED OPTIONS        IN-THE-MONEY OPTIONS
                                SHARES                              AT FISCAL YEAR-END       AT FISCAL YEAR-END (2)
                               ACQUIRED           VALUE       ----------------------------- -----------------------
           NAME            ON EXERCISE (#)   REALIZED ($)(1)   EXERCISABLE   UNEXERCISABLE        EXERCISABLE        UNEXERCISABLE
- ------------------------- ----------------- ----------------- ------------- --------------- ----------------------- --------------
<S>                       <C>               <C>               <C>           <C>             <C>                     <C>
John W. Jackson .........     230,730           $3,475,762       619,270       860,000            $11,850,996        $15,640,819

Sol J. Barer ............     225,000           $2,887,380       527,238       310,002            $10,205,963        $ 5,740,440

Robert J. Hugin .........          --                   --            --       450,000                     --        $ 8,156,250
</TABLE>

- -------------
(1)  Represents the difference between the average high and low trading price of
     the Common Stock on the Nasdaq  National Market on the date the shares were
     acquired  and the  average  high  and low  exercise  price  of the  options
     exercised multiplied by the number of shares acquired upon exercise.

(2)  Represents  the  difference  between the closing market price of the Common
     Stock as reported  by the Nasdaq  National  Market on December  31, 1999 of
     $23.33  per  share, as  adjusted for the Split, and the exercise  price per
     share of in-the-money options multiplied by the number of shares underlying
     the in-the-money options.

COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

     The Compensation  Committee determines the Company's executive compensation
policies.   The  Compensation  Committee  determines  the  compensation  of  the
Company's  executive  officers and approves and oversees the  administration  of
incentive  compensation programs for all employees including executive officers.
The Compensation Committee is composed solely of outside directors.

EXECUTIVE COMPENSATION POLICIES AND PROGRAMS

     The  Company's  executive  compensation  program is part of a  company-wide
program covering all employees.  The program's goals are to attract, retain, and
motivate  employees,   and  it  utilizes  incentives  such  that  employees  and
stockholders share the same risks. The compensation  program is designed to link
compensation to performance.

     A portion  of each  employee's  compensation  relates to the grant of stock
options,  and such grants are based on the  successful  attainment  of strategic
corporate, business unit, and individual goals.

     The  Company  does not have a pension  plan or other  capital  accumulation
program. Grants of stock options are therefore of great importance to executives
as well as all  employees.  Any  long-term  value to be derived from such grants
will be consistent with stockholder gains.


                                       10
<PAGE>

     Executive and employee  compensation  includes  salary,  employment-related
benefits, and long-term incentive compensation:

     Salary.  Salaries are set  competitively  relative to the biotechnology and
pharmaceutical  industries -- industries with which the Company competes for its
highly skilled  personnel.  Individual  experience and performance is considered
when setting  salaries  within the range for each  position.  Annual reviews are
held and adjustments are made based on attainment of individual goals.

     Benefits.  All employees are eligible for similar benefits, such as health,
disability, and life insurance.

     Long-Term  Incentive  Compensation.  An incentive  compensation  program is
established  annually.  The  purpose of this  program  is to  provide  financial
incentives to executives  and employees to achieve  annual  corporate,  business
unit,  and individual  goals.  The incentive  program also aligns  executive and
employee  interests with those of stockholders by using grants of stock options.
Such grants vest over time thereby  encouraging  continued  employment  with the
Company.  The  size of  grants  is tied to  comparative  biotechnology  industry
practices.  To determine  such  comparative  data, the Company relies on outside
compensation  consultants,  the  Company's  auditors,  and third party  industry
surveys.

     Under the Company's 1999 incentive program,  it was agreed,  subject to the
achievement  of certain  goals in 1999 by the  Company,  that the Company  would
grant at a future date  options to purchase  shares of common  stock.  A similar
incentive  program has been  designed for 2000 based on attainment of corporate,
business  unit,  and  individual  goals.  The  program  is open  to all  regular
full-time employees, other than the executive officers of the Company.

     Chief Executive Officer  Compensation.  Pursuant to Mr. Jackson's  contract
with the Company entered into on September 30, 1997, Mr. Jackson received a base
salary of $300,000 for 1999.  Mr.  Jackson also received a bonus of $390,000 for
1999.  Factors  considered  in  determining  Mr.  Jackson's  bonus  included the
successful  attainment of several important milestones in the development of the
Company's products,  as well comparisons to total compensation packages of chief
executive  officers at  corporations  within the Company's  industry that are of
comparable size.

                             Members of the Compensation Committee


                             Richard C.E. Morgan, Chairman
                             Frank T. Cary
                             Jack L. Bowman
                             Lee J. Schroeder


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The  current  members  of  the  Compensation  Committee  are  Richard C. E.
Morgan,  Chairman,  Frank  T. Cary, Jack L. Bowman and Lee J. Schroeder. Each is
an outside director of the Company.


                                       11
<PAGE>

PERFORMANCE GRAPH

     The following  graph shows changes over the past five years in the value of
$100  invested in: 1) the Company's  Common Stock;  2) the Standard & Poor's 500
Index;  3) the NASDAQ  Pharmaceutical  Index;  and 4) the  NASDAQ  Biotechnology
Index.

     The graph  shows the value of $100  invested  on  December  31, 1994 in the
Company's  Common  Stock  or in one of the  indexes,  as  applicable,  including
reinvestment of dividends, at December 31 for each of 1994-1999.

                               [GRAPHIC OMITTED]


                                       12
<PAGE>

               COMPARISON OF FIVE-YEAR CUMULATIVE TOTAL RETURN*
                AMONG CELGENE CORPORATION, THE S & P 500 INDEX,
                     THE NASDAQ PHARMACEUTICAL INDEX AND THE
                           NASDAQ BIOTECHNOLOGY INDEX



<TABLE>
<S>                               <C>       <C>       <C>       <C>       <C>       <C>
                                  12/94     12/95     12/96     12/97     12/98     12/99
Celgene Corporation ...........    100       238       198       150       273      1,244
S & P 500 .....................    100       138       169       226       290       351
Nasdaq Pharmaceutical .........    100       183       184       190       242       450
Nasdaq Biotechnology ..........    100       189       188       188       271       546
</TABLE>

* $100 INVESTED ON 12/31/94 IN STOCK OR INDEX -
   INCLUDING REINVESTMENT OF DIVIDENDS.
   FISCAL YEAR ENDING DECEMBER 31.

     The  foregoing  graph is based on  historical  data and is not  necessarily
indicative  of  future  performance.  This  graph  shall  not  be  deemed  to be
"soliciting  material"  or  to be  "filed"  with  the  Securities  and  Exchange
Commission  or subject to  Regulations  14A and 14C under the Exchange Act or to
the liabilities of Section 18 under the Exchange Act.


                   PROPOSAL TWO: APPROVAL OF AN AMENDMENT TO
                        THE 1998 LONG-TERM INCENTIVE PLAN

     The  stockholders  of the Company are asked to approve an  amendment to the
1998 Incentive Plan to increase the aggregate  number of shares of the Company's
Common Stock that may be subject to awards granted  thereunder from 4,500,000 to
6,500,000, as adjusted for the Split. The 1998 Incentive Plan was adopted by the
Board of Directors on May 6, 1998 and approved by the Company's  stockholders at
the 1998 Annual Meeting of Stockholders. The Board of Directors amended the 1998
Incentive  Plan on June 22, 1999 to permit the Committee  (as defined  below) to
clarify the persons to whom non-qualified stock options may be transferred.  The
affirmative vote of the holders of at least a majority of the outstanding shares
of Common Stock  present and entitled to vote at the Annual  Meeting is required
to approve the  amendment to the 1998  Incentive  Plan to increase the aggregate
number of shares of the Company's Common Stock that may be subject to awards.

BACKGROUND OF THE PROPOSAL TO AMEND THE 1998 INCENTIVE PLAN

     As of March 31, 2000,  options to purchase 3,523,440 shares of Common Stock
have been granted under the 1998 Incentive Plan at exercise  prices based on the
fair market  value of the shares of the  Company's  Common  Stock  ranging  from
$5.2083 to $56.8333, as adjusted for the Split. Of the options granted, none has
been canceled, leaving a total of 976,560 available for future grants out of the
aggregate of 4,500,000  shares of Common  Stock  authorized  for grant under the
1998  Incentive  Plan. As of May 1, 2000, the closing price of a share of Common
Stock was  $47.375.  The Board of  Directors  believes  that stock  ownership by
employees  provides  performance  incentives and fosters pride in the Company to
the benefit of both the Company and its stockholders.  Accordingly, the Board of
Directors  recommends  that  stockholders  approve  the  amendment  to the  1998
Incentive  Plan to increase the aggregate  number of shares of Company's  Common
Stock that may be subject to awards as described  below.  The Board of Directors
approved the amendment of the 1998 Incentive Plan on May 5, 2000, subject to the
approval of stockholders.


                                       13
<PAGE>

SUMMARY OF THE PLAN.

     Background;  Purpose;  Eligibility. The following is a brief summary of the
principal  provisions of the Plan.  This summary does not purport to be complete
and is  qualified  in its entirety by reference to the text of this Plan, a copy
of which may be obtained  upon written  request to the Company at the  Company's
principal business address.

     Administration.  The 1998  Incentive Plan is  administered  by a Management
Compensation  and Development  Committee or such other committee or subcommittee
appointed from time to time by the Board, which is intended to consist of two or
more  non-employee  directors,  each of whom will be, to the extent  required by
Rule 16b-3 ("Rule 16b-3") under the Exchange Act and Section 162(m) of the Code,
a  non-employee  director  as defined in Rule 16b-3 and an outside  director  as
defined under Section  162(m) of the Code (the  "Committee").  If for any reason
the  appointed  Committee  does not meet the  requirements  of Rule 16b-3 of the
Exchange Act or Section 162(m) of the Code, the validity of the awards,  grants,
interpretation  or other  actions of the  Committee  will not be  affected.  The
Committee has the full authority to select those individuals eligible to receive
awards and the amount and type of awards. Terms and conditions of awards will be
set forth in written  grant  agreements,  the terms of which will be  consistent
with the terms of the 1998 Incentive Plan.  Awards under the 1998 Incentive Plan
may not be made on or after the tenth  anniversary  of the date of its adoption,
but awards granted prior to such date may extend beyond that date.

     Types of Awards.  The 1998  Incentive Plan provides for the grant of any or
all of the following  types of awards:  (i) stock options,  including  incentive
stock options and non-qualified stock options;  (ii) stock appreciation  rights,
in tandem with stock options or freestanding;  (iii) restricted  stock; and (iv)
performance-based awards.

     Stock  Options.  Options may be in the form of incentive  stock  options or
non-qualified  stock  options.  The  Committee  will,  with regard to each stock
option,  determine the number of shares  subject to the option,  the term of the
option (which shall not exceed ten years, provided, however, that the term of an
incentive  stock option  granted to a 10%  stockholder  of the Company shall not
exceed five years), the exercise price per share of stock subject to the option,
the vesting  schedule (if any), and the other  material terms of the option.  No
stock  option may have an  exercise  price less than the fair  market  value (as
defined in the 1998  Incentive  Plan) of the  Common  Stock at the time of grant
(or, in the case of an incentive  stock option  granted to a 10%  stockholder of
the Company, 110% of the fair market value of the Common Stock).

     The  exercise  price upon  exercise  may be paid in cash,  shares of Common
Stock owned by the recipient for at least six months and for which the recipient
has good  title  free and clear of any liens or  encumbrances  or, if the Common
Stock is traded on a national  securities  exchange,  through  the  delivery  of
irrevocable  instructions  to a broker to deliver to the Company an amount equal
to the exercise  price.  The Committee  may also provide,  at the time of grant,
that the shares to be issued upon the  exercise of a stock option be in the form
of restricted stock or may, in the stock option agreement, reserve a right to do
so after the time of grant.

     Stock  Appreciation  Rights  ("SARs").  The Committee may grant SARs either
with  a  stock  option   ("Tandem  SARs")  or  independent  of  a  stock  option
("Non-Tandem  SARs").  An SAR is a right to receive a payment  either in cash or
Common Stock as the Committee may determine, equal in value to the excess of the
fair market  value of a share of Common  Stock on the date of exercise  over the
reference  price per share of Common Stock  established  in connection  with the
grant of the SAR. The  reference  price per share  covered by an SAR will be the
per share  exercise  price of the related option in the case of a Tandem SAR and
will be the per share fair market value of Common Stock on the date of the grant


                                       14
<PAGE>

in the case of a Non-Tandem  SAR. The Committee may also grant  "limited  SARs,"
either as Tandem SARs or Non-Tandem SARs, which may become exercisable only upon
the occurrence of a Change in Control (as defined in the 1998 Incentive Plan) or
such other event as the Committee may, in its sole discretion,  designate at the
time of grant or thereafter.

     Restricted  Stock. The Committee may award shares of restricted stock. Upon
the award of  restricted  stock,  the  recipient has all rights of a stockholder
with respect to the shares, including,  without limitation, the right to receive
dividends,  the right to vote such shares and,  subject to and conditioned  upon
the full  vesting of the shares of  restricted  stock,  the right to tender such
shares.  Unless  otherwise  determined by the Committee at grant, the payment of
dividends,  if any,  shall be deferred until the date that the relevant share of
restricted stock vests.

     Recipients  of  restricted  stock are  required to enter into a  restricted
stock award  agreement with the Company which states the  restrictions  to which
the  shares  are  subject  and the  criteria  or date or  dates  on  which  such
restrictions will lapse.  Within these limits,  based on service,  attainment of
performance  goals, and such other factors as the Committee may determine in its
sole  discretion,  or a combination  thereof,  the Committee may provide for the
lapse of such restrictions in installments in whole or in part or may accelerate
or waive such restrictions at any time. If the lapse of the relevant restriction
is based on the attainment of performance  goals,  the Committee shall establish
the goals,  formulae or standards and the applicable  vesting percentage for the
restricted stock awards applicable to recipients.

     Performance-Based  Awards.  The  Committee may award Common Stock and other
awards that are valued in whole or in part by reference to, or are payable in or
otherwise  based on,  Common  Stock  either alone or in addition to or in tandem
with stock options,  stock appreciation rights, or restricted stock. Such awards
shall be subject to such terms and conditions as the Committee may prescribe.

     Amendment and Termination.  The 1998 Incentive Plan provides that it may be
amended, in whole or in part, suspended or terminated by the Board of Directors,
except that no such amendment,  suspension or termination,  without  stockholder
approval to the extent such  approval is required by  applicable  state law, the
applicable provisions of Rule 16b-3 of the Exchange Act or for the exception for
performance-based compensation under Section 162(m) of the Code or to the extent
applicable to incentive stock options, Section 422 of the Code, may increase the
aggregate  number of shares of Common  Stock  reserved for awards or the maximum
individual  limits,  change the  classification of employees eligible to receive
awards,  decrease the minimum  exercise  price of any stock  option,  extend the
maximum  option  period  under  the 1998  Incentive  Plan or to make  any  other
amendment that would require stockholder  approval under the Code, Rule 16b-3 of
the Exchange  Act or the rules of any exchange or system on which the  Company's
securities are listed or traded.

     Share and Other Limitations.  A maximum of 6,500,000 shares of Common Stock
as adjusted for the Split may be issued or used for reference  purposes pursuant
to the 1998  Incentive  Plan as amended.  The maximum number of shares of Common
Stock  subject to stock  options  or SARs that may be granted to any  individual
under the 1998  Incentive  Plan  shall be  750,000  for any  fiscal  year of the
Company during the term of the 1998  Incentive  Plan, as adjusted for the Split.
If an SAR or a limited  SAR is granted in tandem with a stock  option,  it shall
apply against the  individual  limits for both stock options and SARs,  but only
once against the maximum  number of shares  available  under the 1998  Incentive
Plan.  To the extent that shares of Common Stock for which stock options or SARs
are  permitted  to be granted  to a  recipient  during a  calendar  year are not
covered by a grant of a stock  option or an SAR during the calendar  year,  such
shares of Common  Stock  shall not be  available  for grant or  issuance  to the
recipient in any subsequent calendar year during the term of this 1998 Incentive
Plan.

     The  Committee  may make  appropriate  adjustments  to the number of shares
available  for  awards  and the  terms  of  outstanding  awards  under  the 1998
Incentive Plan to reflect any change in the Company's


                                       15
<PAGE>

capital structure or business,  stock dividend,  stock split,  recapitalization,
reorganization,  merger,  consolidation or sale of all or substantially  all the
assets of the Company.

     Change in Control. Unless determined otherwise by the Committee at the time
of grant,  upon a Change in Control (as defined in the 1998 Incentive Plan), all
vesting and forfeiture  conditions,  restrictions and limitations in effect with
respect to any outstanding  award will immediately lapse and any unvested awards
will automatically become 100% vested.  However,  unless otherwise determined by
the  Committee  at  the  time  of  grant  or  thereafter,   no  acceleration  of
exercisability  shall  occur  with  regard to  certain  stock  options  that the
Committee reasonably  determines in good faith prior to a Change in Control will
be  honored  or assumed or new  rights  substituted  therefor  by a  recipient's
employer immediately following the Change in Control. The Committee may also, in
its sole discretion, provide for accelerated vesting of an award at any time.

     Miscellaneous. Although awards will generally be nontransferable (except by
will or the laws of descent and  distribution),  the  Committee may determine at
the  time of grant or  thereafter  that a  non-qualified  stock  option  that is
otherwise  nontransferable  is  transferable  in  whole  or in part  and in such
circumstances,  and under such conditions,  as specified by the Committee.  If a
non-qualified  stock option is transferable,  it is anticipated that the options
may be transferred solely to immediate family members or trusts, partnerships or
other  family  entities and, to  the  extent  permitted  by  the  Committee,  to
charitable organizations.

CERTAIN U.S. FEDERAL INCOME TAX CONSEQUENCES.

     The rules  concerning the federal income tax  consequences  with respect to
stock options granted pursuant to the 1998 Incentive Plan are highly  technical.
In addition, the applicable statutory provisions are subject to change and their
application may vary in individual  circumstances.  Therefore,  the following is
designed  to  provide  a  general   understanding  of  the  federal  income  tax
consequences;  it does not set forth any state or local income tax or estate tax
consequences that may be applicable.

     Incentive Stock Options.  Options granted under the 1998 Incentive Plan may
be incentive  stock  options as defined in the Code,  provided that such options
satisfy the requirements under the Code therefor. In general,  neither the grant
nor the exercise of an incentive  stock option will result in taxable  income to
the optionee or a deduction to the  Company.  The sale of Common Stock  received
pursuant to the exercise of an option which satisfied all the requirements of an
incentive  stock option,  as well as the holding  period  requirement  described
below,  will result in a long-term capital gain or loss to the optionee equal to
the  difference  between the amount  realized on the sale and the exercise price
and will not result in a tax  deduction  to the  Company.  To receive  incentive
stock  option  treatment,  the  optionee  must not  dispose of the Common  Stock
purchased  pursuant  to the  exercise  of an option  either (i) within two years
after the option is granted or (ii) within one year after the date of  exercise.

     If all  requirements  for incentive  stock option  treatment other than the
holding period rules are satisfied, the recognition of income by the optionee is
deferred until disposition of the Common Stock, but, in general, any gain (in an
amount  equal to the lesser of (i) the fair market  value of the Common Stock on
the date of exercise (or,  with respect to officers,  the date that sale of such
stock would not create liability ("Section 16(b) liability") under Section 16(b)
of the Exchange Act) minus the exercise price or (ii) the amount realized on the
disposition  minus the  exercise  price) is  treated  as  ordinary  income.  Any
remaining  gain is treated as long-term or short-term  capital gain depending on
the optionee's  holding period for the stock disposed of. The Company  generally
will be  entitled  to a  deduction  at that time equal to the amount of ordinary
income realized by the optionee.


                                       16
<PAGE>

     The 1998  Incentive Plan provides that an optionee may pay for Common Stock
received upon the exercise of an option  (including  an incentive  stock option)
with other  shares of Common  Stock held for at least six months.  In general an
optionee's  transfer of stock acquired  pursuant to the exercise of an incentive
stock  option,  to acquire  other stock in  connection  with the  exercise of an
incentive stock option may result in ordinary  income if the  transferred  stock
has not met the minimum  statutory  holding  period  necessary for favorable tax
treatment as an incentive stock option. For example, if an optionee exercises an
incentive  stock  option  and uses the stock so  acquired  to  exercise  another
incentive stock option within the two-year or one-year holding periods discussed
above,  the optionee  may realize  ordinary  income  under the rules  summarized
above.

     Non-Qualified  Stock Options. An optionee will realize no taxable income at
the time he or she is granted a non-qualified  stock option.  Such conclusion is
predicated  on  the  assumption   that,  under  existing   Treasury   Department
regulations,  a  non-qualified  stock option,  at the time of its grant,  has no
readily ascertainable fair market value. Ordinary income will be realized when a
non-qualified stock option is exercised, provided the Common Stock issued is not
restricted  stock.  The amount of such income will be equal to the excess of the
fair market value on the  exercise  date of the shares of Common Stock issued to
an optionee over the exercise price. The optionee's  holding period with respect
to the shares acquired will begin on the date of exercise.

     The tax basis of the stock acquired upon the exercise of any option will be
equal to the sum of (i) the  exercise  price of such  option and (ii) the amount
included in income with respect to such option. Any gain or loss on a subsequent
sale of the stock will be either a long-term or short-term capital gain or loss,
depending on the  optionee's  holding  period for the stock  disposed of. If the
Common Stock issued is restricted stock,  different rules may apply.  Subject to
the limitation under Sections 162(m) and 280G of the Code (as described  below),
the Company  generally  will be entitled to a deduction  for federal  income tax
purposes at the same time and in the same amount as the  optionee is  considered
to have realized ordinary income in connection with the exercise of the option.

     Certain Other Tax Issues. In addition,  (i) officers of the Company subject
to Section 16(b)  liability may be subject to special rules regarding the income
tax  consequences  concerning  their  awards;  (ii)  any  entitlement  to a  tax
deduction on the part of the  corporation is subject to the  applicable  federal
tax rules (including,  without limitation,  Section 162(m) of the Code regarding
the $1,000,000 limitation on deductible  compensation);  (iii) in the event that
the exercisability or vesting of any award is accelerated because of a Change in
Control, payments relating to the awards (or a portion thereof), either alone or
together with certain other payments,  may constitute  parachute  payments under
Section 280G of the Code,  which  excess  amounts may be subject to excise taxes
and may be nondeductible  by the Company;  and (iv) the exercise of an incentive
stock option may have  implications  in the  computation of alternative  minimum
taxable income.

     In general, Section 162(m) of the Code denies a publicly held corporation a
deduction  for  federal  income  tax  purposes  for  compensation  in  excess of
$1,000,000 per year per person to its chief executive officer and the four other
officers  whose  compensation  is disclosed in its proxy  statement,  subject to
certain exceptions. Options will generally qualify under one of these exceptions
if they are granted  under a plan that states the maximum  number of shares with
respect  to which  options  may be granted to any  employee  during a  specified
period  and the plan  under  which  the  options  are  granted  is  approved  by
stockholders  and is  administered  by a  compensation  committee  comprised  of
outside  directors.  The  1998  Incentive  Plan is  intended  to  satisfy  these
requirements   with  respect  to  options.   Awards  of  restricted  shares  and
performance-based   awards   generally   do  not  satisfy  the   exception   for
performance-based compensation under Section 162(m) of the Code.

     The 1998  Incentive Plan is not subject to any of the  requirements  of the
Employee Retirement Income Security Act of 1974, as amended.  The 1998 Inventive
Plan is not, nor is it intended to be,  qualified  under  Section  401(a) of the
Code.

RECOMMENDATION OF THE BOARD OF DIRECTORS

                 THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
                   A VOTE FOR THE ADOPTION OF THIS PROPOSAL


                                       17

<PAGE>

                      PROPOSAL THREE: INDEPENDENT AUDITORS

     The Board of Directors has appointed KPMG LLP, independent certified public
accountants, to audit the books and records of the Company for the current year.
The affirmative  vote of a majority of the shares voted at the Annual Meeting is
required for the  ratification of the Board of Directors'  selection of KPMG LLP
as the Company's  independent  auditors for the fiscal year ending  December 31,
2000.

     Representatives  of KPMG LLP are  expected  to be present at the meeting of
stockholders  and will be given an  opportunity  to make a statement  if they so
desire. They are expected to be available to respond to appropriate questions.

RECOMMENDATION OF THE BOARD OF DIRECTORS

                 THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
                   A VOTE FOR THE ADOPTION OF THIS PROPOSAL


                                       18

<PAGE>

                              STOCKHOLDER PROPOSALS

     Stockholders  of the  Company  wishing  to include  proposals  in the proxy
material  in  relation  to the annual  meeting of the Company to be held in 2001
must submit the same in writing so as to be received at the executive  office of
the Company on or before  January 15, 2001. If notice of a stockholder  proposal
is not received by the Company on or before April 1, 2001,  the persons named in
the enclosed form of proxy will have discretionary authority to vote all proxies
with respect thereto in accordance with their best judgment. Such proposals must
also meet the other  requirements  of the rules of the  Securities  and Exchange
Commission relating to stockholders' proposals.


                                  OTHER MATTERS

     Upon written request addressed to the Company's  Secretary at 7 Powder Horn
Drive,  Warren,  New Jersey 07059 from any person solicited herein,  the Company
will  provide,  at no cost, a copy of the Form 10-K Annual Report filed with the
Commission for the fiscal year ended December 31, 1999.

     The Board of  Directors  of the Company  does not know of any matters to be
brought before the Annual Meeting other than the matters set forth in the Notice
of Annual  Meeting of  Stockholders  and matters  incident to the conduct of the
Meeting.  However,  if any other matters should  properly come before the Annual
Meeting,  the persons named in the enclosed  proxy card will have  discretionary
authority to vote all proxies with respect thereto in accordance with their best
judgment.

                                  By Order of the Board of Directors,
                                  JOHN W. JACKSON
                                  Chairman of the Board and
                                  Chief Executive Officer

May 8, 2000

STOCKHOLDERS  ARE REQUESTED TO DATE AND SIGN THE ENCLOSED PROXY AND RETURN IT IN
THE  ENCLOSED,  SELF-ADDRESSED ENVELOPE. NO POSTAGE IS REQUIRED IF MAILED IN THE
UNITED  STATES.  YOUR PROMPT RESPONSE WILL BE HELPFUL, AND YOUR COOPERATION WILL
BE APPRECIATED.


                                       19

<PAGE>

                               CELGENE CORPORATION
                                      PROXY

         The  undersigned  hereby  appoints  John W.  Jackson,  Sol J. Barer and
Robert J. Hugin, and each of them, with power of substitution,  to represent and
to vote on behalf of the  undersigned  all of the shares of Celgene  Corporation
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of  Stockholders  to be held at the offices of Proskauer  Rose LLP,  26th floor,
1585 Broadway, New York, New York 10036 on Tuesday, June 20, 2000, at 1:00 p.m.,
local time, and at any adjournment or adjournments thereof,  hereby revoking all
proxies  heretofore  given  with  respect  to such  stock,  upon  the  following
proposals  more fully  described  in the notice of and proxy  statement  for the
meeting (receipt of which is hereby acknowledged).

THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR (1), (2) AND (3)

<TABLE>
<CAPTION>

<S>                                                 <C>
1.   ELECTION OF DIRECTORS
        |_|   FOR all nominees listed below         |_|  WITHHOLD AUTHORITY
              (except as marked to the contrary)         to vote for all nominees listed



 John W. Jackson, Sol J. Barer, Frank T. Cary, Richard C.E. Morgan, Walter L. Robb, Lee J. Schroeder, Arthur Hull Hayes, Jr.,
                          Gilla Kaplan and Jack Bowman

</TABLE>


INSTRUCTION:  TO  WITHHOLD  AUTHORITY  TO VOTE FOR ANY  INDIVIDUAL,  WRITE  THAT
NOMINEE'S NAME ON THE SPACE PROVIDED BELOW:

- -----------------------------------------------------

2.       PROPOSAL TO APPROVE THE AMENDMENT OF THE 1998 LONG-TERM  INCENTIVE PLAN
         TO INCREASE THE NUMBER OF SHARES OF COMMON STOCK THAT MAY BE SUBJECT TO
         AWARDS THEREUNDER FROM 4,500,000 SHARES TO 6,500,000 SHARES

               |_|  FOR        |_|  AGAINST         |_|     ABSTAIN


3.       PROPOSAL TO RATIFY THE APPOINTMENT OF KPMG LLP AS THE INDEPENDENT
         CERTIFIED PUBLIC ACCOUNTANTS OF THE COMPANY FOR THE FISCAL YEAR
         ENDING DECEMBER 31, 2000

               |_|  FOR        |_|  AGAINST         |_|     ABSTAIN

4.       In their  discretion,  upon such  other  matters as may  properly  come
         before the meeting.

THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS.

THIS PROXY, WHEN PROPERLY EXECUTED,  WILL BE VOTED IN THE MANNER DIRECTED HEREIN
BY THE  UNDERSIGNED  STOCKHOLDER.  IF NO DIRECTION  IS MADE,  THIS PROXY WILL BE
VOTED FOR ELECTION OF ALL  NOMINEES  FOR  DIRECTOR  LISTED IN PROPOSAL 1 AND FOR
PROPOSALS 2 AND 3.

|_| I will attend the meeting                  |_| I will not attend the meeting

Note:    Please sign  exactly as names  appear on this proxy.  Where  shares are
         held by joint  tenants,  both  should  sign.  If signing  as  attorney,
         executor, administrator, trustee or guardian, please give full title as
         such. If a corporation, please sign in full corporate name by president
         or  other  authorized   person.  If  a  partnership,   please  sign  in
         partnership name by an authorized person.

                                                     Dated:

                                    -------------------------------
                                    -------------------------------
                                    -------------------------------
                                                   (Signature)

                                          PLEASE   MARK,  SIGN,  DATE  AND
                                          RETURN THIS PROXY PROMPTLY USING
                                          THE ENCLOSED ENVELOPE.


                                       20

<PAGE>

                                                                       EXHIBIT A








                               CELGENE CORPORATION

                          1998 LONG-TERM INCENTIVE PLAN

<PAGE>



            (This document  reflects all amendments to the 1998 Incentive  Plan,
            including the amendment to be approved by  stockholders  at the 2000
            Annual Meeting,  and reflects the three-for-one stock split declared
            by the Company and paid on April 14, 2000)

                                TABLE OF CONTENTS
<TABLE>
<CAPTION>
                                                                                                               Page
                                                                                                               ----

<S>                    <C>                                                                                       <C>
ARTICLE 1.             PURPOSE....................................................................................1

ARTICLE 2.             DEFINITIONS................................................................................1

ARTICLE 3.             ADMINISTRATION.............................................................................5

ARTICLE 4.             SHARE AND OTHER LIMITATIONS................................................................8

ARTICLE 5.             ELIGIBILITY...............................................................................10

ARTICLE 6.             STOCK OPTIONS.............................................................................11

ARTICLE 7.             RESTRICTED STOCK AWARDS...................................................................13

ARTICLE 8.             STOCK APPRECIATION RIGHTS.................................................................15

ARTICLE 9.             PERFORMANCE-BASED AWARDS..................................................................18

ARTICLE 10.            NON-TRANSFERABILITY AND TERMINATION PROVISIONS............................................19

ARTICLE 11.            CHANGE IN CONTROL PROVISIONS..............................................................21

ARTICLE 12.            TERMINATION OR AMENDMENT OF THE PLAN......................................................22

ARTICLE 13.            UNFUNDED STATUS OF PLAN...................................................................23

ARTICLE 14.            GENERAL PROVISIONS........................................................................23

ARTICLE 15.            APPROVAL OF BOARD AND STOCKHOLDERS........................................................26

ARTICLE 16.            TERM OF PLAN..............................................................................26

ARTICLE 17.            NAME OF PLAN..............................................................................27

</TABLE>

                                        i

<PAGE>



                               CELGENE CORPORATION
                          1998 LONG-TERM INCENTIVE PLAN

                                   ARTICLE 1.

                                     PURPOSE

         The purpose of this Celgene  Corporation 1998 Long-Term  Incentive Plan
(the  "Plan") is to enhance the  profitability  and value of the Company and its
Affiliates for the benefit of its  stockholders by enabling the Company to offer
selected management  (excluding  Non-Employee  Directors) and other employees of
the  Company  and its  Affiliates,  stock  based  incentives  and  other  equity
interests in the Company,  thereby  creating a means to raise the level of stock
ownership by employees in order to attract, retain and reward such employees and
strengthen  the  mutuality  of interests  between  employees  and the  Company's
stockholders.

                                   ARTICLE 2.

                                   DEFINITIONS

         For purposes of this Plan, the following terms shall have the following
meanings:

                  2.1.  "Affiliate"  shall mean other than the Company,  (i) any
         Subsidiary,  (ii) any  corporation in an unbroken chain of corporations
         ending with the Company which owns stock  possessing 50% or more of the
         total combined voting power of all classes of stock in one of the other
         corporations in such chain,  (iii) any  corporation,  trade or business
         (including,  without  limitation,  a partnership  or limited  liability
         company)  which is  controlled  50% or more  (whether by  ownership  of
         stock,  assets or an equivalent  ownership interest or voting interest)
         by the  Company  or one of its  Affiliates,  or (iv) any other  entity,
         approved by the Committee as an Affiliate  under the Plan, in which the
         Company or any of its Affiliates has a material equity interest.

                  2.2. "Award" shall mean any award under this Plan of any Stock
         Option,    Restricted    Stock,    Stock    Appreciation    Right,   or
         Performance-Based Award. All Awards, shall be granted by, confirmed by,
         and  subject  to the  terms  of, a written  agreement  executed  by the
         Company and the Participant.

                  2.3.  "Board" or "Board of Directors"  shall mean the Board of
         Directors of the Company.

                  2.4.  "Cause"  shall  mean,  with  respect to a  Participant's
         Termination of Employment: (i) in the case where there is no employment
         agreement, consulting agreement, change in control agreement or similar
         agreement in effect between the


<PAGE>

         Company or an Affiliate and the Participant at the time of the relevant
         grant or Award, or where there is an employment  agreement,  consulting
         agreement,  change in control  agreement or similar agreement in effect
         at the time of the relevant  grant or Award but such agreement does not
         define  "cause"  (or  words  of  like  import),  termination  due  to a
         Participant's dishonesty, fraud,  insubordination,  willful misconduct,
         refusal  to perform  services  (for any  reason  other than  illness or
         incapacity)  or  materially  unsatisfactory  performance  of his or her
         duties for the Company or an  Affiliate or (ii) in the case where there
         is an employment  agreement,  consulting  agreement,  change in control
         agreement  or similar  agreement  in effect  between  the Company or an
         Affiliate  and the  Participant  at the time of the  relevant  grant or
         Award that  defines  "cause"  (or words of like  import)  and a "cause"
         termination  would be  permitted  under  such  agreement  at that time,
         termination  that is or would be deemed to be for  "cause" (or words of
         like  import) as  defined  under such  agreement;  provided,  that with
         regard to any  agreement  that  conditions  "cause" on  occurrence of a
         change in control,  such  definition of "cause" shall not apply until a
         change in control  actually  takes place and then only with regard to a
         termination thereafter.

                  2.5.  "Change in Control"  shall have the meaning set forth in
         Article 11.

                  2.6.  "Code" shall mean the Internal  Revenue Code of 1986, as
         amended.

                  2.7.  "Committee"  shall mean a  Management  Compensation  and
         Development Committee or such other committee or subcommittee appointed
         from time to time by the Board,  which  shall be intended to consist of
         two (2) or more non-employee  directors,  each of whom shall be, to the
         extent  required by Rule 16b-3 (as  defined  herein),  a  "non-employee
         director"  as  defined in Rule 16b-3  and,  to the extent  required  by
         Section 162(m) of the Code and any regulations thereunder,  an "outside
         director" as defined under Section 162(m) of the Code.  Notwithstanding
         the foregoing,  if and to the extent that no Committee exists which has
         the  authority to administer  the Plan,  the functions of the Committee
         shall be  exercised  by the  Board.  If for any  reason  the  appointed
         Committee  does not  meet the  requirements  of Rule  16b-3 or  Section
         162(m) of the Code, such  noncompliance  with the  requirements of Rule
         16b-3 or Section  162(m) of the Code shall not affect the  validity  of
         the Awards, grants, interpretations or other actions of the Committee.

                  2.8. "Common Stock" means the common stock, $.01 par value per
         share, of the Company.

                  2.9.   "Company"   means  Celgene   Corporation,   a  Delaware
         corporation, and its successors by merger, consolidation or otherwise.

                  2.10.  "Disability"  shall mean,  with  respect to an Eligible
         Employee,  a  permanent  and total  disability  as  defined  in Section
         22(e)(3) of the Code. A Disability shall only be deemed to occur at the
         time of the  determination  by the Committee or the Board,  as the case
         may be, of the Disability.

                                        2

<PAGE>

                  2.11.  "Effective  Date"  shall mean May 4,  1998,  subject to
         Article 15.

                  2.12.  "Eligible  Employees"  shall mean the  employees of the
         Company and its Affiliates who are eligible pursuant to Article 5 to be
         granted Awards under this Plan.

                  2.13. "Exchange Act" shall mean the Securities Exchange Act of
         1934.

                  2.14.  "Fair Market  Value" for purposes of this Plan,  unless
         otherwise  required  by any  applicable  provision  of the  Code or any
         regulations  issued  thereunder,  shall  mean,  as of any date the last
         sales price reported for the Common Stock on the applicable date (i) as
         reported by the principal  national  securities  exchange in the United
         States on which it is then  traded,  or (ii) if not  traded on any such
         national  securities  exchange,  as  quoted on an  automated  quotation
         system sponsored by the National Association of Securities Dealers. For
         purposes of the exercise of any Stock Appreciation Right the applicable
         date  shall  be the  date a  notice  of  exercise  is  received  by the
         Committee or, if not a day on which the applicable  market is open, the
         next day that it is open.

                  2.15.  "Family  Member",  shall  mean,  with  respect  to  any
         Participant,  any child,  stepchild,  grandchild,  parent,  stepparent,
         grandparent,   spouse,   former   spouse,   sibling,   niece,   nephew,
         mother-in-law,      father-in-law,     son-in-law,     daughter-in-law,
         brother-in-law, or sister-in-law, including adoptive relationships, any
         person  sharing  the  Participant's  household  (other than a tenant or
         employee),  a trust in which  these  persons  have more than 50% of the
         beneficial  interest,  a  foundation  in which  these  persons  (or the
         Participant)  control the management of assets, and any other entity in
         which  these  persons  (or the  Participant)  own more  than 50% of the
         voting interests.

                  2.16.  "Incentive  Stock  Option"  shall mean any Stock Option
         awarded under this Plan intended to be and  designated as an "Incentive
         Stock Option" within the meaning of Section 422 of the Code.

                  2.17.  "Limited Stock Appreciation  Right" shall mean an Award
         made  pursuant to Section  8.5 of the Plan which may be a Tandem  Stock
         Appreciation Right or a Non- Tandem Stock Appreciation Right.

                  2.18.  "Non-Employee  Director"  shall mean a director  of the
         Company who is not an active employee of the Company or an Affiliate.

                  2.19. "Non-Qualified Stock Option" shall mean any Stock Option
         awarded under this Plan that is not an Incentive Stock Option.

                  2.20. "Participant" shall mean an Eligible Employee to whom an
         Award has been made pursuant to this Plan.

                                        3

<PAGE>

                  2.21.  "Performance-Based  Award"  shall  mean an  Award  made
         pursuant  to Article 9 of this Plan of the right to  receive  awards of
         Common  Stock and other  Awards  that are valued in whole or in part by
         reference to, or are payable in or otherwise based on, Common Stock.

                  2.22. "Performance Period" shall have the meaning set forth in
         Section 9.1.

                  2.23.  "Restricted  Stock"  shall  mean an award of  shares of
         Common  Stock  under this Plan that is subject  to  restrictions  under
         Article 7.

                  2.24. "Restriction Period" shall have the meaning set forth in
         Subsection  7.3(a)  with  respect  to  Restricted  Stock  for  Eligible
         Employees.

                  2.25.  "Retirement" shall mean a Participant's  Termination of
         Employment without Cause at or after age fifty-five (55).

                  2.26.  "Rule 16b-3" shall mean Rule 16b-3 under  Section 16(b)
         of the Exchange Act as then in effect or any successor provisions.

                  2.27.  "Section  162(m) of the Code" shall mean the  exception
         for performance-based compensation under Section 162(m) of the Code and
         any Treasury regulations thereunder.

                  2.28.  "Stock   Appreciation   Right"  shall  mean  the  right
         (pursuant  to an  Award  granted  under  Article  8).  A  Tandem  Stock
         Appreciation Right shall mean the right to surrender to the Company all
         (or a portion) of a Stock  Option in exchange  for an amount in cash or
         stock  equal to the excess of (i) the Fair  Market  Value,  on the date
         such Stock  Option (or such  portion  thereof) is  surrendered,  of the
         Common Stock  covered by such Stock  Option (or such portion  thereof),
         over (ii) the  aggregate  exercise  price of such Stock Option (or such
         portion thereof).  A Non-Tandem Stock Appreciation Right shall mean the
         right to receive an amount in cash or stock  equal to the excess of (x)
         the Fair Market Value of a share of Common Stock on the date such right
         is  exercised,  over (y) the  aggregate  exercise  price of such right,
         otherwise than on surrender of a Stock Option.

                  2.29.  "Stock  Option"  or  "Option"  shall mean any option to
         purchase shares of Common Stock granted to Eligible  Employees pursuant
         to Article 6.

                  2.30.  "Subsidiary"  shall mean any subsidiary  corporation of
         the Company within the meaning of Section 424(f) of the Code.

                  2.31.  "Ten Percent  Stockholder"  shall mean a person  owning
         stock of the  Company  possessing  more than ten  percent  (10%) of the
         total  combined  voting power of all classes of stock of the Company or
         its  Subsidiaries  or its  parent  corporations,  as defined in Section
         424(e) of the Code.

                                        4

<PAGE>

                  2.32. "Termination of Employment" shall mean (i) a termination
         of service  (for  reasons  other than a military or  personal  leave of
         absence  granted by the Company) of a Participant  from the Company and
         its  Affiliates or (ii) when an entity which is employing a Participant
         ceases to be an Affiliate,  unless the  Participant  thereupon  becomes
         employed by the Company or another Affiliate.

                  2.33. "Transfer" or "Transferred" or "Transferable" shall mean
         anticipate,  alienate,  attach, sell, assign, pledge, encumber, charge,
         hypothecate or otherwise transfer.

                                   ARTICLE 3.

                                 ADMINISTRATION

                  3.1.  The  Committee.  The  Plan  shall  be  administered  and
interpreted by the Committee.

                  3.2. Awards.  The Committee shall have full authority to grant
to Eligible  Employees,  pursuant to the terms of this Plan:  (i) Stock Options,
(ii)   Restricted   Stock,   (iii)   Stock   Appreciation   Rights,   and   (iv)
Performance-Based Awards. In particular, the Committee shall have the authority:

                           (a) to select the  Eligible  Employees  to whom Stock
         Options,    Restricted   Stock,   Stock   Appreciation    Rights,   and
         Performance-Based Awards may from time to time be granted hereunder;

                           (b) to  determine  whether and to what  extent  Stock
         Options,    Restricted   Stock,   Stock   Appreciation    Rights,   and
         Performance-Based  Awards or any combination thereof, are to be granted
         hereunder to one or more Eligible Employees;

                           (c) to  determine,  in  accordance  with the terms of
         this Plan,  the number of shares of Common  Stock to be covered by each
         Award to an Eligible Employee granted hereunder;

                           (d)  to  determine  the  terms  and  conditions,  not
         inconsistent  with  the  terms  of  this  Plan,  of any  Award  granted
         hereunder to an Eligible Employee  (including,  but not limited to, the
         exercise or purchase price, any restriction or limitation,  any vesting
         schedule or  acceleration  thereof,  or any forfeiture  restrictions or
         waiver  thereof,  regarding  any Stock Option or other  Award,  and the
         shares of Common Stock relating thereto, based on such factors, if any,
         as the Committee shall determine, in its sole discretion);

                           (e) to determine whether and under what circumstances
         a Stock Option may be settled in cash and/or Common Stock under Section
         6.3(d);

                                        5

<PAGE>

                           (f) to  determine  whether,  to what extent and under
         what  circumstances  to provide loans (which may be on a recourse basis
         and shall bear  interest at the rate the  Committee  shall  provide) to
         Eligible Employees in order to exercise Options under this Plan;

                           (g) to  determine  whether  to  require  an  Eligible
         Employee,  as a condition of the granting of any Award,  to not sell or
         otherwise  dispose of shares  acquired  pursuant to the  exercise of an
         Option  or as an  Award  for a  period  of  time as  determined  by the
         Committee,   in  its  sole  discretion,   following  the  date  of  the
         acquisition of such Option or Award; and

                           (h) to determine whether a Stock  Appreciation  Right
         is a Tandem Stock  Appreciation  Right or Non-Tandem Stock Appreciation
         Right.

                  3.3.  Guidelines.  Subject to Article 12 hereof, the Committee
shall have the authority to adopt, alter and repeal such  administrative  rules,
guidelines and practices governing this Plan and perform all acts, including the
delegation of its  administrative  responsibilities,  as it shall,  from time to
time, deem advisable; to construe and interpret the terms and provisions of this
Plan and any Award issued under this Plan (and any agreements relating thereto);
and to otherwise  supervise the  administration  of this Plan. The Committee may
correct any defect,  supply any omission or reconcile any  inconsistency in this
Plan or in any  agreement  relating  thereto  in the manner and to the extent it
shall deem  necessary  to carry this Plan into effect but only to the extent any
such action would be permitted under the applicable provisions of Rule 16b-3 and
Section  162(m) of the Code.  The  Committee may adopt  special  guidelines  and
provisions  for  persons  who are  residing  in, or  subject  to,  the taxes of,
countries  other  than the  United  States to  comply  with  applicable  tax and
securities laws and may impose any limitations and  restrictions  that they deem
necessary  to  comply  with  the  applicable  tax  and  securities  laws of such
countries other than the United States.  To the extent  applicable,  the Plan is
intended  to  comply  with the  applicable  requirements  of Rule  16b-3 and the
exception for  performance-based  compensation  under Section 162(m) of the Code
with  regard to Options  and Stock  Appreciation  Rights  and shall be  limited,
construed and interpreted in a manner so as to comply therewith.

                  3.4.  Decisions Final. Any decision,  interpretation  or other
action made or taken in good faith by or at the  direction of the  Company,  the
Board, or the Committee (or any of its members)  arising out of or in connection
with the Plan shall be within the absolute  discretion  of all and each of them,
as the case may be, and shall be final,  binding and  conclusive  on the Company
and all  employees  and  Participants  and their  respective  heirs,  executors,
administrators, successors and assigns.

                  3.5.  Reliance  on  Counsel.  The  Company,  the  Board or the
Committee may consult with legal counsel,  who may be counsel for the Company or
other  counsel,  with respect to its  obligations or duties  hereunder,  or with
respect to any action or  proceeding  or any  question of law,  and shall not be
liable with respect to any action taken or omitted by it in good faith  pursuant
to the advice of such counsel.

                                        6
<PAGE>

                  3.6.  Procedures.  If the  Committee is  appointed,  the Board
shall  designate  one of the  members  of the  Committee  as  chairman  and  the
Committee  shall hold meetings,  subject to the By-Laws of the Company,  at such
times and places as it shall deem advisable. A majority of the Committee members
shall constitute a quorum.  All determinations of the Committee shall be made by
a majority of the members  present.  Any  decision or  determination  reduced to
writing and signed by all the Committee  members in accordance  with the By-Laws
of the Company,  shall be fully as effective as if it had been made by a vote at
a meeting duly called and held. The Committee shall keep minutes of its meetings
and shall make such rules and  regulations for the conduct of its business as it
shall deem advisable.

                  3.7.     Designation of Consultants/Liability.

                           (a) The  Committee  may  designate  employees  of the
         Company  and  professional  advisors  to assist  the  Committee  in the
         administration  of the Plan and may grant  authority  to  employees  to
         execute agreements or other documents on behalf of the Committee.

                           (b) The  Committee  may employ  such  legal  counsel,
         consultants,  appraisers  and agents as it may deem  desirable  for the
         administration  of the Plan and may rely upon any opinion received from
         any such counsel,  appraiser or consultant and any computation received
         from any such consultant,  appraiser or agent. Expenses incurred by the
         Committee in the  engagement of any such  counsel,  consultant or agent
         shall be paid by the Company. The Board, the Committee, its members and
         any employee of the Company designated  pursuant to paragraph (a) above
         shall not be liable for any action or determination  made in good faith
         with respect to the Plan. To the maximum extent permitted by applicable
         law, no officer or  employee of the Company or member or former  member
         of the  Committee  or of the Board  shall be liable  for any  action or
         determination  made in good faith with respect to the Plan or any Award
         granted under it. To the maximum extent permitted by applicable law and
         the Certificate of Incorporation  and By-Laws of the Company and to the
         extent not covered by insurance,  each officer, employee of the Company
         and member or former  member of the  Committee or of the Board shall be
         indemnified  and  held  harmless  by the  Company  against  any cost or
         expense (including  reasonable fees of counsel reasonably acceptable to
         the Company) or liability  (including  any sum paid in  settlement of a
         claim with the approval of the Company), and advanced amounts necessary
         to pay the  foregoing  at the earliest  time and to the fullest  extent
         permitted, arising out of any act or omission to act in connection with
         the  Plan,  except  to  the  extent  arising  out  of  such  officer's,
         employee's,  member's or former  member's own fraud or bad faith.  Such
         indemnification  shall be in addition to any rights of  indemnification
         the  officers,  employees,  directors  or members  or former  officers,
         directors  or  members  may have  under  applicable  law or  under  the
         Certificate of  Incorporation  or By-Laws of the Company or Affiliates.
         Notwithstanding  anything else herein,  this  indemnification  will not
         apply to the  actions  or  determinations  made by an  individual  with
         regard to Awards granted to him or her under this Plan.

                                        7

<PAGE>

                                   ARTICLE 4.

                           SHARE AND OTHER LIMITATIONS

                  4.1.     Shares.

                           (a)  General  Limitation.  The  aggregate  number  of
         shares of  Common  Stock  which  may be  issued  or used for  reference
         purposes  under  this Plan or with  respect  to which all Awards may be
         granted shall not exceed  6,500,000  shares (subject to any increase or
         decrease pursuant to Section 4.2). If any Option or Stock  Appreciation
         Right granted  under this Plan  expires,  terminates or is canceled for
         any reason  without having been exercised in full, the number of shares
         of Common Stock underlying any unexercised Stock  Appreciation Right or
         Option  shall again be  available  for the purposes of Awards under the
         Plan.  If any shares of  Restricted  Stock awarded under this Plan to a
         Participant  are  forfeited  for any  reason,  the number of  forfeited
         shares of Restricted Stock shall again be available for the purposes of
         Awards  under  the  Plan.  If a Tandem  Stock  Appreciation  Right or a
         Limited Stock  Appreciation  Right is granted in tandem with an Option,
         such grant shall only apply once  against the maximum  number of shares
         of Common Stock which may be issued under this Plan.

                           (b)  Individual  Participant  Limitations.   (i)  The
                  maximum number of shares of Common Stock subject to any Option
                  which may be granted under this Plan during any fiscal year of
                  the Company to each Eligible  Employee shall be 750,000 shares
                  (subject to any increase or decrease pursuant to Section 4.2).

                                    (ii) The maximum  number of shares of Common
                  Stock  subject to any Stock  Appreciation  Right  which may be
                  granted  under this Plan during any fiscal year of the Company
                  to each Eligible  Employee shall be 750,000 shares (subject to
                  any increase or decrease pursuant to Section 4.2). If a Tandem
                  Stock  Appreciation  Right or Limited Stock Appreciation Right
                  is granted in tandem with an Option it shall apply against the
                  Eligible  Employee's  individual  share  limitations  for both
                  Stock Appreciation Rights and Options.


                                    (iii) To the  extent  that  shares of Common
                  Stock for  which  Options  or Stock  Appreciation  Rights  are
                  permitted to be granted to a  Participant  pursuant to Section
                  4.1(b)  during a calendar  year of the Company are not covered
                  by a grant of an Option or a Stock  Appreciation  Right in the
                  Company's calendar year, such shares of Common Stock shall not
                  be available for grant or issuance to the  Participant  in any
                  subsequent calendar year during the term of this Plan.

                                        8
<PAGE>

                  4.2.     Changes.

                           (a) The existence of the Plan and the Awards  granted
         hereunder  shall not  affect in any way the right or power of the Board
         or the stockholders of the Company to make or authorize any adjustment,
         recapitalization,  reorganization  or  other  change  in the  Company's
         capital  structure or its business,  any merger or consolidation of the
         Company or its Affiliates, any issue of bonds, debentures, preferred or
         prior  preference  stock  ahead  of  or  affecting  Common  Stock,  the
         dissolution or liquidation of the Company or its  Affiliates,  any sale
         or  transfer  of all or part of its  assets  or  business  or any other
         corporate act or proceeding.

                           (b) In the event of any such  change  in the  capital
         structure or business of the Company by reason of any stock dividend or
         distribution,  stock split or reverse  stock  split,  recapitalization,
         reorganization,   merger,  consolidation,   split-up,   combination  or
         exchange of shares, distribution with respect to its outstanding Common
         Stock or capital stock other than Common Stock, reclassification of its
         capital stock, conversion of the Company's preferred stock, issuance of
         warrants  or  options  to  purchase  any  Common  Stock  or  securities
         convertible  into Common Stock,  any sale or Transfer of all or part of
         the Company's  assets or business,  or any similar change affecting the
         Company's capital structure or business,  then the aggregate number and
         kind of shares  which  thereafter  may be issued  under this Plan,  the
         number  and kind of shares  or other  property  (including  cash) to be
         issued upon exercise of an  outstanding  Option or other Awards granted
         under this Plan and the purchase  price thereof shall be  appropriately
         adjusted  consistent  with such change in such manner as the  Committee
         may deem  equitable to prevent  substantial  dilution or enlargement of
         the rights granted to, or available for,  Participants under this Plan,
         and any such adjustment determined by the Committee in good faith shall
         be binding  and  conclusive  on the Company  and all  Participants  and
         employees  and  their  respective  heirs,  executors,   administrators,
         successors and assigns.

                           (c) Fractional  shares of Common Stock resulting from
         any  adjustment in Options or Awards  pursuant to Section 4.2(a) or (b)
         shall be aggregated  until,  and eliminated at, the time of exercise by
         rounding-down  for fractions less than one-half  (1/2) and  rounding-up
         for  fractions  equal  to or  greater  than  one-half  (1/2).  No  cash
         settlements  shall be made with respect to fractional shares eliminated
         by rounding.  Notice of any adjustment  shall be given by the Committee
         to each  Participant  whose Option or Award has been  adjusted and such
         adjustment (whether or not such notice is given) shall be effective and
         binding for all purposes of the Plan.

                           (d) In the  event of a  merger  or  consolidation  in
         which the  Company is not the  surviving  entity or in the event of any
         transaction that results in the acquisition of substantially all of the
         Company's outstanding Common Stock by a single person or entity or by a
         group of persons and/or entities acting in concert,  or in the event of
         the  sale or  transfer  of all or  substantially  all of the  Company's
         assets  (all  of  the  foregoing  being  referred  to  as  "Acquisition
         Events"), then the Committee may,

                                        9
<PAGE>

         in its sole  discretion,  terminate all  outstanding  Options and Stock
         Appreciation Rights of Eligible Employees,  effective as of the date of
         the Acquisition Event, by delivering notice of termination to each such
         Participant at least twenty (20) days prior to the date of consummation
         of the  Acquisition  Event;  provided,  that during the period from the
         date  on  which  such  notice  of   termination  is  delivered  to  the
         consummation of the Acquisition Event, each such Participant shall have
         the  right to  exercise  in full all of his or her  Options  and  Stock
         Appreciation  Rights that are then  outstanding  (without regard to any
         limitations  on  exercisability  otherwise  contained  in the Option or
         Award  Agreements)  but  contingent on  occurrence  of the  Acquisition
         Event, and, provided that, if the Acquisition Event does not take place
         within a  specified  period  after  giving  such  notice for any reason
         whatsoever, the notice and exercise shall be null and void.

         If an  Acquisition  Event occurs,  to the extent the Committee does not
terminate the outstanding Options and Stock Appreciation Rights pursuant to this
Section 4.2(d), then the provisions of Section 4.2(b) shall apply.

                  4.3.  Purchase  Price.  Notwithstanding  any provision of this
Plan to the contrary,  if authorized  but previously  unissued  shares of Common
Stock are  issued  under  this  Plan,  such  shares  shall  not be issued  for a
consideration which is less than as permitted under applicable law.

                                   ARTICLE 5.

                                   ELIGIBILITY

                  All management  (excluding  Non-Employee  Directors) and other
employees of the Company and its Affiliates are eligible to be granted  Options,
Restricted Stock, Stock Appreciation Rights, and Performance-Based  Awards under
this Plan.  Eligibility  under this Plan shall be determined by the Committee in
its sole and absolute discretion.

                                   ARTICLE 6.

                                  STOCK OPTIONS

                  6.1. Options. Each Stock Option granted hereunder shall be one
of two types: (i) an Incentive Stock Option intended to satisfy the requirements
of Section 422 of the Code or (ii) a Non-Qualified Stock Option.

                  6.2.  Grants.  The Committee shall have the authority to grant
to any Eligible  Employee one or more  Incentive  Stock  Options,  Non-Qualified
Stock  Options,  or both  types of Stock  Options  (in each case with or without
Stock Appreciation Rights). To the extent that any Stock Option does not qualify
as an Incentive Stock Option  (whether  because of its provisions or the time or
manner of its exercise or otherwise),  such Stock Option or the portion  thereof
which does not qualify,  shall constitute a separate Non-Qualified Stock Option.
Notwithstanding  any  other  provision  of  this  Plan  to the  contrary  or any
provision in

                                       10
<PAGE>

an  agreement  evidencing  the grant of an Option to the  contrary,  any  Option
granted to an Eligible  Employee of an  Affiliate  (other than one  described in
Section 2.1(i) or (ii)) shall be a Non- Qualified Stock Option.

                  6.3. Terms of Options. Options granted under Article 6 of this
Plan shall be subject to Article 10 and the following terms and conditions,  and
shall be in such form and contain  such  additional  terms and  conditions,  not
inconsistent with the terms of this Plan, as the Committee shall deem desirable:

                           (a)  Option  Price.  The  option  price  per share of
         Common  Stock   purchasable  under  an  Incentive  Stock  Option  or  a
         Non-Qualified  Stock Option shall be determined by the Committee at the
         time of grant but shall not be less than 100% of the Fair Market  Value
         of the share of Common Stock at the time of grant;  provided,  however,
         if an Incentive  Stock Option is granted to a Ten Percent  Stockholder,
         the purchase price shall not be less than 110% of the Fair Market Value
         of the share of Common Stock at the time of grant.

                           (b) Option Term.  The term of each Stock Option shall
         be fixed by the  Committee,  but no Stock Option  shall be  exercisable
         more  than ten  (10)  years  after  the date  the  Option  is  granted;
         provided,  however,  that the term of an Incentive Stock Option granted
         to a Ten Percent Stockholder may not exceed five (5) years.

                           (c)   Exercisability.    Stock   Options   shall   be
         exercisable  at such  time or  times  and  subject  to such  terms  and
         conditions as shall be  determined  by the  Committee at grant.  If the
         Committee  provides,  in its  discretion,  that  any  Stock  Option  is
         exercisable   subject  to  certain  limitations   (including,   without
         limitation,  that it is  exercisable  only in  installments  or  within
         certain time periods),  the Committee may waive such limitations on the
         exercisability  at any  time at or  after  grant  in  whole  or in part
         (including,  without  limitation,  that the  Committee  may  waive  the
         installment exercise provisions or accelerate the time at which Options
         may be  exercised),  based on such  factors,  if any, as the  Committee
         shall determine, in its sole discretion.

                           (d)  Method  of   Exercise.   Subject   to   whatever
         installment   exercise  and  waiting  period   provisions  apply  under
         subsection  (c) above,  Stock  Options may be  exercised in whole or in
         part at any time during the Option term,  by giving  written  notice of
         exercise  to  the  Company  specifying  the  number  of  shares  to  be
         purchased.  Such notice shall be  accompanied by payment in full of the
         purchase price as follows: (i) in cash or by check, bank draft or money
         order  payable to the order of  Company,  (ii) if the  Common  Stock is
         traded on a national securities exchange, the Nasdaq Stock Market, Inc.
         or quoted on a national  quotation  system  sponsored  by the  National
         Association of Securities Dealers,  through the delivery of irrevocable
         instructions  to a broker to deliver  promptly to the Company an amount
         equal to the  purchase  price,  (iii) by payment in full or part in the
         form of Common Stock owned by the  Participant for a period of at least
         6 months (and for which the  Participant  has good title free and clear
         of
                                       11

<PAGE>

         any  liens  and  encumbrances)  based on the Fair  Market  Value of the
         Common Stock on the payment date as  determined by the Committee or the
         Board or (iv) on such other terms and  conditions  as may be acceptable
         to the Committee or the Board, as applicable. No shares of Common Stock
         shall be issued until payment  therefor,  as provided herein,  has been
         made or provided for.

                           (e) Incentive Stock Option Limitations. To the extent
         that the  aggregate  Fair Market  Value  (determined  as of the time of
         grant) of the  Common  Stock  with  respect  to which  Incentive  Stock
         Options  are  exercisable  for the first time by an  Eligible  Employee
         during any  calendar  year under the Plan and/or any other stock option
         plan of the Company or any Subsidiary or parent corporation (within the
         meaning of Section 424(e) of the Code) exceeds  $100,000,  such Options
         shall be treated as Options which are not Incentive  Stock Options.  In
         addition,  if an  Eligible  Employee  does not remain  employed  by the
         Company,  any Subsidiary or parent  corporation  (within the meaning of
         Section  424(e) of the Code) at all times  from the time the  Option is
         granted  until three (3) months  prior to the date of exercise (or such
         other  period as  required by  applicable  law),  such Option  shall be
         treated as an Option which is not an Incentive Stock Option.

                  Should the  foregoing  provision not be necessary in order for
         the Stock Options to qualify as Incentive Stock Options,  or should any
         additional  provisions  be required,  the  Committee may amend the Plan
         accordingly,  without the  necessity of  obtaining  the approval of the
         stockholders of the Company.

                  Without the written  consent of the  Company,  no Common Stock
         acquired  by a  Participant  upon the  exercise of an  Incentive  Stock
         Option granted  hereunder may be disposed of by the Participant  within
         two (2) years from the date such  Incentive  Stock  Option was granted,
         nor within one (1) year after the  transfer of such Common Stock to the
         Participant; provided, however, that a transfer to a trustee, receiver,
         or other  fiduciary  in any  insolvency  proceeding,  as  described  in
         Section  422(c)(3)  of the  Code,  shall  not be  deemed  to be  such a
         disposition.

                           (f)  Form  of  Options.  Subject  to  the  terms  and
         conditions  and within the  limitations of the Plan, an Option shall be
         evidenced  by such form of  agreement  or grant as is  approved  by the
         Committee.

                           (g) Form of Settlement.  In its sole discretion,  the
         Committee  may  provide,  at the time of grant,  that the  shares to be
         issued  upon the  exercise  of a Stock  Option  shall be in the form of
         Restricted Stock, or may, in the Option  agreement,  reserve a right to
         so provide after the time of grant.

                           (h) Other Terms and  Conditions.  Options may contain
         such other provisions,  which shall not be inconsistent with any of the
         foregoing  terms of the Plan, as the Committee  shall deem  appropriate
         including,  without  limitation,  permitting  "reloads." With regard to
         such  "reloads",  the Committee  shall have the

                                       12
<PAGE>

         authority  (but  not  an  obligation)  to  include  within  any  Option
         agreement a provision  entitling  the  optionee to a further  Option (a
         "Reload Option") if the optionee  exercises the Option evidenced by the
         Option agreement,  in whole or in part, by surrendering other shares of
         the Company  held by the  optionee for at least six (6) months prior to
         such date of  surrender in  accordance  with the Plan and the terms and
         conditions of the Option  agreement.  Any Reload Option shall not be an
         Incentive  Stock  Option,  shall be for a number of shares equal to the
         number of surrendered shares, the exercise price thereof shall be equal
         to the Fair Market Value of the Common Stock on the date of exercise of
         such original Option,  shall become exercisable if the purchased shares
         are held for a minimum period of time established by the Committee, and
         shall be subject to such other terms and  conditions  as the  Committee
         may determine.

                                   ARTICLE 7.

                             RESTRICTED STOCK AWARDS

                  7.1. Awards of Restricted  Stock.  Shares of Restricted  Stock
may be issued to Eligible  Employees either alone or in addition to other Awards
granted under the Plan. The Committee  shall  determine the eligible  persons to
whom, and the time or times at which,  grants of Restricted  Stock will be made,
the  number  of  shares  to be  awarded,  the  price  (if any) to be paid by the
recipient  (subject to Section 7.2),  the time or times within which such Awards
may be subject to forfeiture,  the vesting  schedule and rights to  acceleration
thereof,  and all other terms and  conditions  of the Awards.  The Committee may
condition  the  grant of  Restricted  Stock  upon the  attainment  of  specified
performance  goals or such other factors as the Committee may determine,  in its
sole discretion.

                  7.2. Awards and Certificates. An Eligible Employee selected to
receive  Restricted  Stock shall not have any rights with respect to such Award,
unless and until such  Participant  has  delivered a fully  executed copy of the
Restricted  Stock Award  agreement  evidencing  the Award to the Company and has
otherwise  complied  with the  applicable  terms and  conditions  of such Award.
Further, such Award shall be subject to the following conditions:

                           (a) Purchase Price.  The purchase price of Restricted
         Stock  shall be fixed by the  Committee.  Subject to Section  4.3,  the
         purchase  price for  shares  of  Restricted  Stock  may be the  minimum
         permitted by applicable law.

                           (b)  Acceptance.  Awards of Restricted  Stock must be
         accepted within a period of ninety (90) days (or such shorter period as
         the  Committee may specify at grant) after the Award date, by executing
         a Restricted  Stock Award  agreement and by paying  whatever  price (if
         any) the Committee has designated thereunder.

                           (c) Legend.  Each Participant  receiving a Restricted
         Stock  Award  shall be issued a stock  certificate  in  respect of such
         shares of Restricted Stock,  unless

                                       13

<PAGE>

         the Committee elects to use another system, such as book entries by the
         transfer  agent, as evidencing  ownership of a Restricted  Stock Award.
         Such certificate  shall be registered in the name of such  Participant,
         and  shall  bear  an  appropriate   legend   referring  to  the  terms,
         conditions, and restrictions applicable to such Award, substantially in
         the following form:

                           "The  anticipation,   alienation,  attachment,  sale,
         transfer,  assignment,  pledge,  encumbrance or charge of the shares of
         stock  represented  hereby  are  subject  to the terms  and  conditions
         (including  forfeiture) of the Celgene Corporation (the "Company") 1998
         Long-Term  Incentive  Plan and an  Agreement  entered  into between the
         registered owner and the Company  dated       . Copies of such Plan and
         Agreement are on file at the principal office of the Company."

                           (d) Custody. The Committee may require that any stock
         certificates  evidencing  such shares be held in custody by the Company
         until the  restrictions  thereon  shall  have  lapsed,  and that,  as a
         condition of any Restricted  Stock Award,  the  Participant  shall have
         delivered a duly signed stock power, endorsed in blank, relating to the
         Common Stock covered by such Award.

                  7.3.  Restrictions  and Conditions on Restricted Stock Awards.
The shares of Restricted Stock awarded pursuant to this Plan shall be subject to
Article 10 and the following restrictions and conditions:

                           (a) Restriction  Period;  Vesting and Acceleration of
         Vesting.  (i) The Participant shall not be permitted to Transfer shares
         of Restricted  Stock awarded under this Plan during a period set by the
         Committee (the "Restriction  Period")  commencing with the date of such
         Award,  as set forth in the Restricted  Stock Award  agreement and such
         agreement shall set forth a vesting schedule and any events which would
         accelerate  vesting of the shares of  Restricted  Stock.  Within  these
         limits,  based on service,  attainment of performance goals established
         pursuant  to Section  7.3(a)(ii)  below  and/or  such other  factors or
         criteria as the  Committee may  determine in its sole  discretion,  the
         Committee   may  provide  for  the  lapse  of  such   restrictions   in
         installments  in whole or in part, or may accelerate the vesting of all
         or any part of any  Restricted  Stock Award  and/or  waive the deferral
         limitations for all or any part of any Restricted Stock Award.

                                    (ii)   Performance   Goals,    Formulae   or
         Standards (the  "Performance  Goals").  If the lapse of restrictions is
         based on the  attainment of  Performance  Goals,  the  Committee  shall
         establish the Performance Goals and the applicable  vesting  percentage
         of the Restricted  Stock Award  applicable to each Participant or class
         of  Participants  in writing prior to the  beginning of the  applicable
         fiscal  year  or at such  later  date as  otherwise  determined  by the
         Committee   and  while  the  outcome  of  the   Performance   Goals  is
         substantially   uncertain.   Such  Performance  Goals  may  incorporate
         provisions for disregarding (or adjusting for) changes in

                                       14
<PAGE>

         accounting  methods,   corporate   transactions   (including,   without
         limitation,  dispositions  and  acquisitions)  and other  similar  type
         events or circumstances.

                           (b) Rights as Stockholder. Except as provided in this
         subsection (b) and subsection (a) above and as otherwise  determined by
         the Committee,  the Participant  shall have, with respect to the shares
         of Restricted  Stock, all of the rights of a holder of shares of Common
         Stock  of the  Company  including,  without  limitation,  the  right to
         receive any  dividends,  the right to vote such shares and,  subject to
         and  conditioned  upon the full vesting of shares of Restricted  Stock,
         the right to tender such shares.  Notwithstanding  the  foregoing,  the
         payment of dividends shall be deferred until, and conditioned upon, the
         expiration of the applicable  Restriction Period, unless the Committee,
         in its sole discretion, specifies otherwise at the time of the Award.

                           (c)   Lapse   of   Restrictions.   If  and  when  the
         Restriction Period expires without a prior forfeiture of the Restricted
         Stock subject to such  Restriction  Period,  the  certificates for such
         shares  shall be  delivered to the  Participant.  All legends  shall be
         removed  from  said  certificates  at  the  time  of  delivery  to  the
         Participant except as otherwise required by applicable law.

                                   ARTICLE 8.

                            STOCK APPRECIATION RIGHTS

                  8.1.  Tandem Stock  Appreciation  Rights.  Stock  Appreciation
Rights  may be granted in  conjunction  with all or part of any Stock  Option (a
"Reference  Stock Option")  granted under this Plan ("Tandem Stock  Appreciation
Rights").  In the case of a  Non-Qualified  Stock  Option,  such  rights  may be
granted either at or after the time of the grant of such Reference Stock Option.
In the case of an Incentive Stock Option, such rights may be granted only at the
time of the grant of such Reference Stock Option.

                  8.2. Terms and Conditions of Tandem Stock Appreciation Rights.
Tandem Stock  Appreciation  Rights  granted  hereunder  shall be subject to such
terms and  conditions,  not  inconsistent  with the  provisions of this Plan, as
shall be determined from time to time by the Committee, including Article 10 and
the following:

                           (a)  Term.  A  Tandem  Stock  Appreciation  Right  or
         applicable  portion  thereof  granted with respect to a Reference Stock
         Option  shall   terminate  and  no  longer  be  exercisable   upon  the
         termination  or exercise of the Reference  Stock  Option,  except that,
         unless otherwise  determined by the Committee,  in its sole discretion,
         at the time of grant,  a Tandem Stock  Appreciation  Right granted with
         respect to less than the full number of shares covered by the Reference
         Stock Option shall not be reduced until and then only to the extent the
         exercise or termination of the Reference Stock Option causes the number
         of shares covered by the Tandem Stock

                                       15

<PAGE>

         Appreciation  Right to exceed the number of shares remaining  available
         and unexercised under the Reference Stock Option.

                           (b) Exercisability.  Tandem Stock Appreciation Rights
         shall be exercisable  only at such time or times and to the extent that
         the Reference  Stock Options to which they relate shall be  exercisable
         in accordance with the provisions of Article 6 and Article 8.

                           (c) Method of Exercise.  A Tandem Stock  Appreciation
         Right may be exercised by an optionee by  surrendering  the  applicable
         portion  of  the  Reference  Stock  Option.   Upon  such  exercise  and
         surrender,  the  Participant  shall be  entitled  to  receive an amount
         determined in the manner  prescribed in this Section 8.2. Stock Options
         which have been so surrendered, in whole or in part, shall no longer be
         exercisable to the extent the related Tandem Stock Appreciation  Rights
         have been exercised.

                           (d)  Payment.  Upon the  exercise  of a Tandem  Stock
         Appreciation  Right a  Participant  shall be entitled to receive up to,
         but no more than,  an amount in cash and/or  Common Stock (as chosen by
         the Committee in its sole  discretion)  equal in value to the excess of
         the Fair  Market  Value of one share of Common  Stock  over the  Option
         price per share specified in the Reference  Stock Option  multiplied by
         the number of shares in respect of which the Tandem Stock  Appreciation
         Right shall have been exercised, with the Committee having the right to
         determine the form of payment.

                           (e) Deemed Exercise of Reference  Stock Option.  Upon
         the exercise of a Tandem Stock Appreciation  Right, the Reference Stock
         Option  or part  thereof  to which  such  Stock  Appreciation  Right is
         related  shall be deemed to have been  exercised for the purpose of the
         limitation  set forth in  Article 4 of the Plan on the number of shares
         of Common Stock to be issued under the Plan.

                  8.3.  Non-Tandem Stock Appreciation  Rights.  Non-Tandem Stock
Appreciation  Rights may also be granted without  reference to any Stock Options
granted under this Plan.

                  8.4.  Terms and  Conditions of Non-Tandem  Stock  Appreciation
Rights. Non- Tandem Stock Appreciation Rights granted hereunder shall be subject
to such terms and conditions, not inconsistent with the provisions of this Plan,
as shall be determined from time to time by the Committee,  including Article 10
and the following:

                           (a)  Term.   The  term  of  each   Non-Tandem   Stock
         Appreciation  Right shall be fixed by the  Committee,  but shall not be
         greater than ten (10) years after the date the right is granted.

                                       16

<PAGE>

                           (b)  Exercisability.  Non-Tandem  Stock  Appreciation
         Rights shall be  exercisable  at such time or times and subject to such
         terms and  conditions as shall be determined by the Committee at grant.
         If the Committee  provides,  in its discretion,  that any such right is
         exercisable   subject  to  certain  limitations   (including,   without
         limitation,  that it is  exercisable  only in  installments  or  within
         certain time periods),  the Committee may waive such  limitation on the
         exercisability  at any  time at or  after  grant  in  whole  or in part
         (including,  without  limitation,  that the  Committee  may  waive  the
         installment  exercise provisions or accelerate the time at which rights
         may be  exercised),  based on such  factors,  if any, as the  Committee
         shall determine, in its sole discretion.

                           (c)  Method  of   Exercise.   Subject   to   whatever
         installment   exercise  and  waiting  period   provisions  apply  under
         subsection  (b)  above,  Non-Tandem  Stock  Appreciation  Rights may be
         exercised  in whole or in part at any time during the option  term,  by
         giving written notice of exercise to the Company  specifying the number
         of Non-Tandem Stock Appreciation Rights to be exercised.

                           (d) Payment.  Upon the exercise of a Non-Tandem Stock
         Appreciation Right a Participant shall be entitled to receive, for each
         right  exercised,  up to,  but no more than,  an amount in cash  and/or
         Common Stock (as chosen by the Committee in its sole discretion)  equal
         in value to the excess of the Fair Market  Value of one share of Common
         Stock on the date the right is exercised  over the Fair Market Value of
         one (1) share of Common  Stock on the date the right was awarded to the
         Participant.

                  8.5. Limited Stock Appreciation  Rights. The Committee may, in
its sole  discretion,  grant Tandem and  Non-Tandem  Stock  Appreciation  Rights
either as a general Stock  Appreciation Right or as a Limited Stock Appreciation
Right.  Limited  Stock  Appreciation  Rights  may be  exercised  only  upon  the
occurrence of a Change in Control or such other event as the  Committee  may, in
its sole  discretion,  designate  at the time of grant or  thereafter.  Upon the
exercise of Limited Stock Appreciation  Rights,  except as otherwise provided in
an Award  agreement,  the Participant  shall receive in cash or Common Stock, as
determined  by the  Committee,  an amount  equal to the  amount (i) set forth in
Section  8.2(d) with  respect to Tandem  Stock  Appreciation  Rights or (ii) set
forth in Section 8.4(d) with respect to Non- Tandem Stock Appreciation Rights.

                                   ARTICLE 9.

                            PERFORMANCE-BASED AWARDS

                  9.1.  Performance-Based  Awards.  Awards of  Common  Stock and
other Awards that are valued in whole or in part by reference to, or are payable
in or  otherwise  based on,  Common  Stock  ("Performance-Based  Awards") may be
granted  either alone or in addition to or in tandem with Stock  Options,  Stock
Appreciation Rights, or Restricted Stock.

                                       17
<PAGE>

         Subject  to the  provisions  of this  Plan,  the  Committee  shall have
authority to  determine  the persons to whom and the time or times at which such
Awards  shall be made,  the  number  of shares  of  Common  Stock to be  awarded
pursuant to such Awards,  and all other conditions of the Awards.  The Committee
may also  provide  for the grant of Common  Stock  under  such  Awards  upon the
completion of a specified Performance Period.

                  9.2.  Terms  and  Conditions.  Performance-Based  Awards  made
pursuant  to  this  Article  9 shall  be  subject  to the  following  terms  and
conditions:

                           (a)  Dividends.  Unless  otherwise  determined by the
         Committee at the time of Award,  subject to the provisions of the Award
         agreement and this Plan, the recipient of an Award under this Article 9
         shall  be  entitled  to  receive,  currently  or on a  deferred  basis,
         dividends or dividend  equivalents with respect to the number of shares
         of Common Stock covered by the Award,  as determined at the time of the
         Award by the Committee, in its sole discretion.

                           (b)  Vesting.  Any Award under this Article 9 and any
         Common  Stock  covered by any such Award shall vest or be  forfeited to
         the extent so provided in the Award  agreement,  as  determined  by the
         Committee, in its sole discretion.

                           (c)  Waiver  of  Limitation.  In  the  event  of  the
         Participant's  Retirement,  Disability or death, or in cases of special
         circumstances,  the  Committee  may, in its sole  discretion,  waive in
         whole or in part any or all of the  limitations  imposed  hereunder (if
         any) with respect to any or all of an Award under this Article.

                           (d) Purchase  Price.  Subject to Section 4.3,  Common
         Stock issued on a bonus basis under this Article 9 may be issued for no
         cash consideration; Common Stock purchased pursuant to a purchase right
         awarded  under  this  Article 9 shall be priced  as  determined  by the
         Committee.

                                   ARTICLE 10.

                 NON-TRANSFERABILITY AND TERMINATION PROVISIONS

         The terms and conditions of this Article 10 shall apply to Awards under
this Plan as follows:

                  10.1. Nontransferability.  No Stock Option, Stock Appreciation
Right,  or  Performance-Based  Award shall be  Transferable  by the  Participant
otherwise  than by will or by the laws of descent  and  distribution.  All Stock
Options  and all Stock  Appreciation  Rights  shall be  exercisable,  during the
Participant's  lifetime, only by the Participant or his or her legal guardian or
representative.  Tandem Stock Appreciation Rights shall be Transferable,  solely
to the  extent  permitted  above,  only with the  underlying  Stock  Option.  In
addition,  except  as  provided  above,  no Stock  Option  shall be  Transferred
(whether by operation of law or otherwise), and no Stock Option shall be subject
to execution,  attachment or similar  process.

                                       18

<PAGE>

Upon any attempt to Transfer any Stock Option,  or in the event of any levy upon
any Stock  Option by reason of any  execution,  attachment  or  similar  process
contrary to the provisions hereof, such Stock Option shall immediately terminate
and become null and void.  Notwithstanding  the  foregoing,  the  Committee  may
determine at the time of grant or thereafter that a  Non-Qualified  Stock Option
that is otherwise not  Transferable  pursuant to this Article 10 is Transferable
to a Family Member in whole or in part and in such circumstances, and under such
conditions, as specified by the Committee. A Non-Qualified Stock Option which is
Transferred  to a Family Member  pursuant to the  preceding  sentence may not be
subsequently Transferred by such Family Member. Shares of Restricted Stock under
Article 7 may not be  Transferred  prior to the date on which shares are issued,
or,  if later,  the date on which any  applicable  restriction,  performance  or
deferral  period  lapses.  No Award  shall,  except  as  otherwise  specifically
provided by law or herein,  be  Transferable  in any manner,  and any attempt to
Transfer any such Award shall be void,  and no such Award shall in any manner be
liable for or subject to the debts, contracts, liabilities, engagements or torts
of any person who shall be entitled  to such  Award,  nor shall it be subject to
attachment or legal process for or against such person.

                  10.2.  Termination  of Employment.  The following  rules apply
with regard to the Termination of Employment of a Participant:

                           (a)   Termination   by   Reason   of   Death.   If  a
         Participant's  Termination  of  Employment  is by reason of death,  any
         Stock  Option or Stock  Appreciation  Right  held by such  Participant,
         unless otherwise  determined by the Committee at grant or, if no rights
         of the Participant's estate are reduced,  thereafter, may be exercised,
         to the extent  exercisable  at the  Participant's  death,  by the legal
         representative  of the  estate,  at any time within a period of one (1)
         year from the date of such death, but in no event beyond the expiration
         of the stated term of such Stock Option or Stock Appreciation Right.

                           (b)   Termination   by   Reason  of   Retirement   or
         Disability.  If a Participant's  Termination of Employment is by reason
         of Retirement  or  Disability,  any Stock Option or Stock  Appreciation
         Right held by such  Participant,  unless  otherwise  determined  by the
         Committee  at grant or, if no rights of the  Participant  are  reduced,
         thereafter,  may  be  exercised,  to  the  extent  exercisable  at  the
         Participant's  termination,  by the Participant  (or the  Participant's
         legal representative to the extent permitted under Section 14.11 or the
         legal  representative  of the  Participant's  estate if the Participant
         dies after termination) at any time within a period (the "Retirement or
         Disability  Period")  which is the  longer of (i) up to ten (10)  years
         after  the date of grant of such  Stock  Option  or Stock  Appreciation
         Right,  such period to be set on a case by case basis by the Committee,
         or (ii)  three (3) years from the date of such  termination;  provided,
         however,  that,  if the  Participant  dies  within such  Retirement  or
         Disability  Period,  any unexercised Stock Option or Stock Appreciation
         Right held by such Participant shall thereafter be exercisable,  to the
         extent to which it was  exercisable at the time of death,  for a period
         of one (1) year (or such other period as the  Committee  may specify at
         grant  or,  if no  rights  of the  Participant's  estate  are  reduced,
         thereafter)
                                       19

<PAGE>

         from the date of such death,  but in no event beyond the  expiration of
         the stated term of such Stock Option or Stock Appreciation Right.

                           (c) Voluntary Resignation or Involuntary  Termination
         Without Cause. If a Participant's Termination of Employment is due to a
         voluntary  resignation or by involuntary  termination without Cause and
         such termination  occurs prior to, or more than ninety (90) days after,
         the  occurrence of an event which would be grounds for  Termination  of
         Employment  by the Company for Cause  (without  regard to any notice or
         cure period requirements), any Stock Option or Stock Appreciation Right
         held by such Participant,  unless otherwise determined by the Committee
         at grant or, if no rights of the Participant  are reduced,  thereafter,
         may be exercised,  to the extent  exercisable  at  termination,  by the
         Participant  at any time  within a period of thirty  (30) days from the
         date of such termination,  but in no event beyond the expiration of the
         stated term of such Stock Option or Stock Appreciation Right.

                           (d)   Termination   for   Cause.   Unless   otherwise
         determined  by  the  Committee  at  grant  or,  if  no  rights  of  the
         Participant are reduced,  thereafter, if a Participant's Termination of
         Employment  is for Cause  for any  reason,  any  Stock  Option or Stock
         Appreciation  Right held by such Participant shall thereupon  terminate
         and expire as of the date of termination.  In the event the termination
         is  an  involuntary   termination  without  Cause  or  is  a  voluntary
         resignation  within ninety (90) days after occurrence of an event which
         would be grounds for Termination of Employment by the Company for Cause
         (without  regard to any notice or cure period  requirement),  any Stock
         Option or Stock  Appreciation Right held by the Participant at the time
         of  occurrence of the event which would be grounds for  Termination  of
         Employment by the Company for Cause shall be deemed to have  terminated
         and  expired  upon  occurrence  of the event which would be grounds for
         Termination of Employment by the Company for Cause.

                           (e)  Termination of Employment for Restricted  Stock.
         Subject to the  applicable  provisions  of the  Restricted  Stock Award
         agreement and this Plan, upon a Participant's Termination of Employment
         for any reason during the relevant  Restriction  Period, all Restricted
         Stock  still  subject  to  restriction  will  vest or be  forfeited  in
         accordance  with the terms and conditions  established by the Committee
         at grant or thereafter.

                           (f)  Termination of Employment for  Performance-Based
         Awards. Subject to the applicable provisions of the Award agreement and
         this Plan,  upon a  Participant's  Termination  of  Employment  for any
         reason,  the  Performance-Based  Award  in  question  will  vest  or be
         forfeited in accordance  with the terms and  conditions  established by
         the Committee at grant or thereafter.

                                       20

<PAGE>

                                   ARTICLE 11.

                          CHANGE IN CONTROL PROVISIONS

                  11.1.  Benefits.  In the event of a Change in  Control  of the
Company (as defined below),  except as otherwise  provided by the Committee upon
the  grant of an Award,  the  Participant  shall be  entitled  to the  following
benefits:

                           (a) All  outstanding  Stock  Options  and the related
         Tandem Stock  Appreciation  Rights and  Non-Tandem  Stock  Appreciation
         Rights of such  Participant,  if any,  granted  prior to the  Change in
         Control  shall be fully  vested and  immediately  exercisable  in their
         entirety.

                           (b)    All    unvested     Restricted    Stock    and
         Performance-Based  Awards  shall  become  fully vested upon a Change in
         Control,   including  without  limitation,   the  following:   (i)  the
         restrictions  to which any shares of Restricted  Stock of a Participant
         granted  prior to the Change in Control are  subject  shall lapse as if
         the applicable Restriction Period had ended upon such Change in Control
         and  (ii)  the   conditions   required  for  vesting  of  any  unvested
         Performance-Based  Awards  shall be  deemed to be  satisfied  upon such
         Change in Control.

                  11.2. Change in Control.  A "Change in Control" shall mean the
occurrence of any of the following:

                           (a) any person (as defined in Section  3(a)(9) of the
         Exchange  Act  and as  used  in  Sections  13(d)  and  14(d)  thereof),
         excluding the Company,  any  subsidiary of the Company and any employee
         benefit plan  sponsored or maintained by the Company or any  subsidiary
         of the  Company  (including  any trustee of any such plan acting in his
         capacity as trustee),  becoming the  "beneficial  owner" (as defined in
         Rule  13d-3  under  the  Exchange  Act) of  securities  of the  Company
         representing thirty percent (30%) of the total combined voting power of
         the Company's then outstanding securities;

                           (b)  the  merger,  consolidation  or  other  business
         combination  of  the  Company  (a  "Transaction"),  other  than  (A)  a
         Transaction  involving  only  the  Company  and  one  or  more  of  its
         subsidiaries,  or (B) a  Transaction  immediately  following  which the
         stockholders  of the  Company  immediately  prior  to  the  Transaction
         continue to have a majority of the voting power in the resulting entity
         and no person (other than those covered by the exceptions in (a) above)
         becomes the  beneficial  owner of securities  of the  resulting  entity
         representing more than twenty-five percent (25%) of the voting power in
         the resulting entity;

                           (c) during any  period of two (2)  consecutive  years
         beginning on or after the Effective  Date, the persons who were members
         of the Board  immediately  before the  beginning  of such  period  (the
         "Incumbent  Directors")  ceasing  (for any

                                       21

<PAGE>

         reason other than death) to constitute at least a majority of the Board
         or the board of  directors of any  successor  to the Company,  provided
         that,  any  director  who was not a director as of the  Effective  Date
         shall be  deemed  to be an  Incumbent  Director  if such  director  was
         elected to the board of directors  by, or on the  recommendation  of or
         with the approval of, at least  two-thirds  of the  directors  who then
         qualified as Incumbent  Directors either actually or by prior operation
         of the  foregoing  unless  such  election,  recommendation  or approval
         occurs as a result of an actual or threatened election contest (as such
         terms are used in Rule 14a-11 of Regulation 14A  promulgated  under the
         Exchange Act or any successor  provision) or other actual or threatened
         solicitation  of proxies or contests by or on behalf of a person  other
         than a member of the Board; or

                           (d) the approval by the  stockholders  of the Company
         of any plan of complete  liquidation of the Company or an agreement for
         the sale of all or substantially all of the Company's assets other than
         the sale of all or substantially  all of the assets of the Company to a
         person or persons who  beneficially  own,  directly or  indirectly,  at
         least fifty percent  (50%) or more of the combined  voting power of the
         outstanding voting securities of the Company at the time of such sale.

                                   ARTICLE 12.

                      TERMINATION OR AMENDMENT OF THE PLAN

         Notwithstanding  any other provision of this Plan, the Board may at any
time,  and from  time to  time,  amend,  in whole or in part,  any or all of the
provisions  of the Plan, or suspend or terminate it entirely,  retroactively  or
otherwise;  provided,  however,  that,  unless  otherwise  required  by  law  or
specifically provided herein, the rights of a Participant with respect to Awards
granted prior to such amendment,  suspension or termination, may not be impaired
without the  consent of such  Participant  and,  provided  further,  without the
approval of the  stockholders  of the Company in accordance with the laws of the
State of Delaware,  to the extent required by the applicable  provisions of Rule
16b-3 or Section 162(m) of the Code, or, with regard to Incentive Stock Options,
Section 422 of the Code,  no amendment  may be made which would (i) increase the
aggregate number of shares of Common Stock that may be issued under this Plan or
the maximum individual Participant limitations under Section 4.1(b), (ii) change
the  classification  of  employees  eligible to receive  Awards under this Plan,
(iii)  decrease the minimum  option price of any Stock  Option,  (iv) extend the
maximum option period under Section 6.3, or (v) require stockholder  approval in
order for the Plan to continue to comply with the applicable  provisions of Rule
16b-3 or Section 162(m) of the Code, or, with regard to Incentive Stock Options,
Section  422 of the  Code.  In no event  may the  Plan be  amended  without  the
approval of the  stockholders  of the Company in accordance  with the applicable
laws or other  requirements to increase the aggregate number of shares of Common
Stock that may be issued under the Plan,  decrease  the minimum  option price of
any Stock Option, or to make any other amendment that would require  stockholder
approval  under the  rules of any  exchange  or  system  on which the  Company's
securities are listed or traded at the request of the Company.

                                       22

<PAGE>


         The  Committee  may amend the terms of any Award  theretofore  granted,
prospectively or retroactively,  but, subject to Article 4 above or as otherwise
specifically provided herein, no such amendment or other action by the Committee
shall impair the rights of any holder without the holder's consent.

                                   ARTICLE 13.

                             UNFUNDED STATUS OF PLAN

         This Plan is intended to constitute  an  "unfunded"  plan for incentive
compensation. With respect to any payments as to which a Participant has a fixed
and vested  interest but which are not yet made to a Participant by the Company,
nothing  contained  herein shall give any such  Participant  any rights that are
greater than those of a general creditor of the Company.

                                   ARTICLE 14.

                               GENERAL PROVISIONS

                  14.1.  Legend. The Committee may require each person receiving
shares of Common  Stock  pursuant to an Award under the Plan to represent to and
agree with the Company in writing that the  Participant  is acquiring the shares
without a view to distribution  thereof,  and that any subsequent offer for sale
or sale of any such shares of Common Stock shall be made either  pursuant to (i)
a  registration  statement on an  appropriate  form under the  Securities Act of
1933,  which  registration  statement  shall have become  effective and shall be
current with respect to the shares of Common  Stock being  offered and sold,  or
(ii) a specific  exemption from the registration  requirements of the Securities
Act of 1933, and that in claiming such exemption the Participant  will, prior to
any offer for sale or sale of shares of Common Stock, obtain a favorable written
opinion,  satisfactory  in form  and  substance  to the  Company,  from  counsel
acceptable to the Company as to the availability of such exception.  In addition
to any  legend  required  by this Plan,  the  certificates  for such  shares may
include  any  legend  which the  Committee  deems  appropriate  to  reflect  any
restrictions on Transfer.

                  All  certificates  for shares of Common Stock  delivered under
the Plan shall be subject to such stock transfer  orders and other  restrictions
as the  Committee  may deem  advisable  under the rules,  regulations  and other
requirements of the Securities and Exchange Commission,  any stock exchange upon
which the Common  Stock is then listed or any  national  securities  association
system upon whose system the Common Stock is then quoted, any applicable Federal
or state securities law, and any applicable corporate law, and the Committee may
cause a legend or legends to be put on any such certificates to make appropriate
reference to such restrictions.

                  14.2.  Other  Plans.  Nothing  contained  in this  Plan  shall
prevent the Board from adopting other or additional  compensation  arrangements,
subject  to  stockholder

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<PAGE>

approval if such  approval is required;  and,  such  arrangements  may be either
generally applicable or applicable only in specific cases.

                  14.3. No Right to Employment.  Neither this Plan nor the grant
of any Award  hereunder  shall give any  Participant or other employee any right
with respect to continuance  of employment by the Company or any Affiliate,  nor
shall  there  be a  limitation  in any way on the  right of the  Company  or any
Affiliate by which an employee is employed to terminate  his  employment  at any
time.

                  14.4.  Withholding of Taxes.  The Company shall have the right
to deduct from any payment to be made to a Participant, or to otherwise require,
prior to the  issuance or delivery of any shares of Common  Stock or the payment
of any cash  hereunder,  payment by the  Participant  of, any Federal,  state or
local taxes  required  by law to be  withheld.  Upon the  vesting of  Restricted
Stock, or upon making an election under Section 83(b) of the Code, a Participant
shall pay all required withholding to the Company.

                  At the  discretion  of the  Committee,  any  such  withholding
obligation  with regard to any  Participant  may be  satisfied  by reducing  the
number of shares of Common Stock otherwise  deliverable or by delivering  shares
of Common Stock already owned.  Any fraction of a share of Common Stock required
to satisfy such tax obligations shall be disregarded and the amount due shall be
paid instead in cash by the Participant.

                  14.5. Listing and Other Conditions.

                           (a) As  long  as the  Common  Stock  is  listed  on a
         national   securities  exchange  or  system  sponsored  by  a  national
         securities  association,  the  issue  of any  shares  of  Common  Stock
         pursuant to an Award shall be conditioned upon such shares being listed
         on such  exchange or system.  The Company  shall have no  obligation to
         issue such shares  unless and until such shares are so listed,  and the
         right to  exercise  any Option  with  respect to such  shares  shall be
         suspended until such listing has been effected.

                           (b) If at any time counsel to the Company shall be of
         the  opinion  that any sale or  delivery  of  shares  of  Common  Stock
         pursuant  to an Award is or may in the  circumstances  be  unlawful  or
         result in the  imposition  of  excise  taxes on the  Company  under the
         statutes,  rules or  regulations of any  applicable  jurisdiction,  the
         Company shall have no  obligation to make such sale or delivery,  or to
         make any application or to effect or to maintain any  qualification  or
         registration under the Securities Act of 1933, as amended, or otherwise
         with  respect  to shares of Common  Stock or  Awards,  and the right to
         exercise any Option shall be  suspended  until,  in the opinion of said
         counsel,  such sale or  delivery  shall be lawful or will not result in
         the imposition of excise taxes on the Company.

                           (c) Upon  termination  of any  period  of  suspension
         under this Section 14.5,  any Award affected by such  suspension  which
         shall not then have expired or

                                       24

<PAGE>

         terminated  shall be reinstated as to all shares  available before such
         suspension and as to shares which would otherwise have become available
         during  the period of such  suspension,  but no such  suspension  shall
         extend the term of any Option.

                  14.6. Governing Law. This Plan shall be governed and construed
in accordance with the laws of the State of Delaware (regardless of the law that
might  otherwise  govern under  applicable  Delaware  principles  of conflict of
laws).

                  14.7.  Construction.  Wherever any words are used in this Plan
in the masculine gender they shall be construed as though they were also used in
the  feminine  gender in all cases where they would so apply,  and  wherever any
words are used herein in the  singular  form they shall be  construed  as though
they were also used in the plural form in all cases where they would so apply.

                  14.8.  Other Benefits.  No Award payment under this Plan shall
be deemed  compensation for purposes of computing  benefits under any retirement
plan of the Company or its  Affiliates  nor affect any benefits  under any other
benefit  plan now or  subsequently  in effect  under which the  availability  or
amount of benefits is related to the level of compensation.

                  14.9.  Costs. The Company shall bear all expenses  included in
administering this Plan,  including expenses of issuing Common Stock pursuant to
any Awards hereunder.

                  14.10.  No Right to Same  Benefits.  The  provisions of Awards
need not be the same  with  respect  to each  Participant,  and such  Awards  to
individual Participants need not be the same in subsequent years.

                  14.11.  Death/Disability.  The Committee may in its discretion
require the  transferee of a Participant to supply it with written notice of the
Participant's  death or Disability  and to supply it with a copy of the will (in
the case of the  Participant's  death) or such other  evidence as the  Committee
deems  necessary  to establish  the  validity of the  transfer of an Award.  The
Committee may also require the agreement of the transferee to be bound by all of
the terms and conditions of the Plan. If the Committee  shall find,  without any
obligation  or  responsibility  of any kind to do so,  that any  person  to whom
payment  is  payable  under  this Plan is unable to care for his or her  affairs
because of disability,  illness or accident, any payment due may be paid to such
person's duly appointed legal  representative  in such manner and proportions as
the Committee may determine, in it sole discretion.  Any such payment shall be a
complete  discharge of the liabilities of the Committee and the Board under this
Plan.

                  14.12.  Section  16(b) of the Exchange  Act. All elections and
transactions under the Plan by persons subject to Section 16 of the Exchange Act
involving  shares of Common  Stock are  intended to comply  with any  applicable
exemptive  condition  under Rule 16b-3.  The  Committee  may establish and adopt
written  administrative  guidelines,  designed  to  facilitate  compliance  with
Section  16(b) of the Exchange  Act, as it may deem  necessary or

                                       25
<PAGE>

proper for the  administration  and operation of the Plan and the transaction of
business thereunder.

                  14.13.  Severability  of  Provisions.  If any provision of the
Plan shall be held invalid or unenforceable, such invalidity or unenforceability
shall not affect any other  provisions  hereof,  and the Plan shall be construed
and enforced as if such provisions had not been included.

                  14.14. Headings and Captions. The headings and captions herein
are provided for reference and convenience only, shall not be considered part of
the Plan, and shall not be employed in the construction of the Plan.

                                   ARTICLE 15.

                       APPROVAL OF BOARD AND STOCKHOLDERS

         The Plan shall not be effective  unless and until approved by the Board
and,  solely to the extent  required by any applicable  law  (including  without
limitation,  approval  required under Rule 16b-3,  Section 162(m) of the Code or
Section 422 of the Code) or registration or stock exchange rule, approved by the
stockholders  of the Company in the manner set forth in such law,  regulation or
rule.

                                   ARTICLE 16.

                                  TERM OF PLAN

         No Award  shall be granted  pursuant  to the Plan on or after the tenth
anniversary  of the  earlier  of the  date the  Plan is  adopted  or the date of
stockholder  approval (if  applicable),  but Awards  granted prior to such tenth
anniversary may extend beyond that date.

                                   ARTICLE 17.

                                  NAME OF PLAN

         This Plan  shall be known as the  Celgene  Corporation  1998  Long-Term
Incentive Plan.

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