CELGENE CORP /DE/
S-4/A, EX-5.1, 2000-08-09
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                     EXHIBIT 5.1


                       [LETTERHEAD OF PROSKAUER ROSE LLP]




August 7, 2000
Board of Directors of
Celgene Corporation
7 Powder Horn Drive
Warren, New Jersey 07059

Ladies and Gentlemen:

You  have  requested  our  opinion  in  connection  with  the  filing by Celgene
Corporation,  a  Delaware  corporation  (the "Company"), with the Securities and
Exchange  Commission  of a Registration Statement on Form S-4 (the "Registration
Statement")  under  the  Securities  Act  of  1933  (the  "Securities Act") with
respect  to  4,144,255  shares of common stock, par value $.01 per share, of the
Company (the "Shares").

We  have participated in the preparation of the Registration Statement, and have
examined  such  records,  documents  and  other  instruments  as  we have deemed
relevant,  and have discussed with representatives of the Company and such other
persons  such  questions  of  fact  as  we have deemed proper and necessary as a
basis  for  rendering  this  opinion. We have also assumed without investigation
the  authenticity of any document submitted to us as an original, the conformity
to  originals of any document submitted to us as a copy, the authenticity of the
originals  of  such  latter documents, the genuineness of all signatures and the
legal capacity of natural persons signing such documents.

Based  on the foregoing, and in reliance thereon, we are of the opinion that the
Shares  (to  the  extent  issued  and  sold  by  the Company as described in the
Registration   Statement)  have  been  duly  authorized  and,  when  issued  and
delivered  as  described  in the Registration Statement, will be validly issued,
fully paid and non-assessable.

We  express no opinion as to the laws of any jurisdiction other than the laws of
the  State  of  New  York, the General Corporation Law of the State of Delaware,
and the laws of the United States of America.

We  hereby  consent  to  the  filing  of  this  opinion  as  an  exhibit  to the
Registration  Statement  and  to  the  reference  to  our firm under the caption
"Legal  Matters" in the Proxy Statement/Prospectus contained in the Registration
Statement.  In  so doing, we do not admit that we are in the category of persons
whose  consent  is  required  under Section 7 of the Securities Act or the rules
and regulations of the Securities and Exchange Commission thereunder.

Very truly yours,


/s/ Proskauer Rose LLP
Proskauer Rose LLP


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