CELGENE CORP /DE/
424B3, 2000-05-24
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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This Prospectus Supplement filed pursuant to Rule 424(b)(3)

Registration No. 333-93759



                              PROSPECTUS SUPPLEMENT

     This is a Supplement, dated May 17, 2000, to the Prospectus, dated
December 28, 1999, with respect to shares of common stock to be offered and sold
by certain selling  stockholders,  including John Hancock Life Insurance Company
and certain of its affiliates (the "Hancock Selling Stockholders").  In order to
reflect the elimination of one of the Hancock Selling  Stockholders,  the change
of name of one of the Hancock Selling  Stockholders,  the elimination of certain
of the shares to be offered by the Hancock Selling Stockholders,  and the change
in shares to be offered by the  Celgene  Corporation  401(k)  Plan,  the tabular
information  appearing  on  page  11 as  it  pertains  to  the  Hancock  Selling
Stockholders and the Celgene  Corporation 401(k) Plan is hereby  supplemented as
follows:

     The following table sets forth information with respect to the Hancock
Selling Stockholders and the Celgene Corporation 401(k) Plan and the respective
number of shares of common stock beneficially owned by each Hancock Selling
Stockholder and the Celgene Corporation 401(k) Plan that may be offered pursuant
to this Prospectus:

HANCOCK SELLING STOCKHOLDER                          NUMBER OF SHARES
- ---------------------------                          ----------------

John Hancock Life Insurance Company*                 654,399(1)

John Hancock Variable Life Insurance                 20,021(2)
  Company

Signature 1A (Cayman), Ltd.                          10,580(3)
[Barnett & Co.: Nominee]

Hancock Mezzanine Partners L.P.                      421,850(4)

Celgene Corporation 401(k) Plan                      40,394(5)

The foregoing share amounts do not give effect to the three-for-one stock split
effected by the Company after the effective date of the Registration Statement,
which incorporated the Prospectus.

*Formerly John Hancock Mutual Life Insurance Company. In addition, after the
filing date, Signature 3 Limited transferred its shares of common stock
effective January 5, 2000 to John Hancock Life Insurance Company.




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(1)  Represents 654,399 shares of common stock issuable upon conversion of
     Celgene Convertible Notes due January 20, 2004 and June 30, 2004.

(2)  Represents 20,021 shares of common stock issuable upon conversion of
     Celgene Convertible Notes due January 20, 2004 and June 30, 2004.

(3)  Represents 10,580 shares of common stock issuable upon conversion of
     Celgene Convertible Notes due January 20, 2004.

(4)  Represents 421,850 shares of common stock issuable upon conversion of
     Celgene Convertible Notes due January 20, 2004 and June 30, 2004.

(5)  Represents 40,394 shares of Celgene common stock granted by Celgene to the
     Celgene Corporation 401(k) Plan (the "Plan") for sale from time to time by
     the trustees of the Plan on behalf of certain employees of Celgene whose
     participation in the Plan has terminated.




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