CELGENE CORP /DE/
10-K, 2000-03-30
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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================================================================================

                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549


                                   FORM 10-K

Annual  Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of
1934 (Fee Required)
For the fiscal year ended December 31, 1999


Transition  Report  Pursuant  to  Section 13 or 15(d) of the Securities Exchange
Act of 1934 (No Fee Required)
For the transition period from ___________ to ___________


Commission File No. 0-16132

                              CELGENE CORPORATION
                              -------------------
            (Exact name of registrant as specified in its charter)

<TABLE>
<S>                                          <C>
                  Delaware                              22-2711928
- ------------------------------------------   --------------------------------
       (State or other jurisdiction of       (I.R.S. Employer Identification)
       incorporation or organization)

            7 Powder Horn Drive
            Warren, New Jersey                             07059
- ------------------------------------------             --------------
(Address of principal executive offices)                 (Zip Code)

</TABLE>

                                (732) 271-1001
             ----------------------------------------------------
             (Registrant's telephone number, including area code)


Securities registered pursuant to Section 12(b) of the Act: None


Securities registered pursuant to Section 12(g) of the Act:

                    Common Stock, par value $.01 per share
                     --------------------------------------
                               (Title of Class)


     Indicate  by  check  mark  whether the registrant (1) has filed all reports
required  to  be  filed by Section 13 or 15(d) of the Securities Exchange Act of
1934  during  the  preceding  12  months  (or  for  such shorter period that the
registrant  was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.

                                  Yes  X   No
                                      ---

     Indicate  by check mark if disclosure of delinquent filers pursuant to Item
405  of  Regulation  S-K  is not contained herein, and will not be contained, to
the   best  of  registrant's  knowledge,  in  definitive  proxy  or  information
statements  incorporated  by  reference  in  Part  III  of this Form 10-K or any
amendment to this Form 10-K.   X
                              ---

     Aggregate   market   value  of  voting  stock  held  by  non-affiliates  of
registrant as of March 1, 2000: $3,530,935,951

     Number  of  shares  of  Common  Stock  outstanding  as  of  March  1, 2000:
21,363,806

================================================================================

<PAGE>

                CELGENE CORPORATION ANNUAL REPORT ON FORM 10-K


                               TABLE OF CONTENTS


<TABLE>
<CAPTION>
ITEM NO.                                                                   PAGE
- -----------                                                               -----
<S>           <C>                                                         <C>
  Part I
   1.         Business ................................................     2
   2.         Properties ..............................................    22
   3.         Legal Proceedings .......................................    22
   4.         Submission of Matters to a Vote of Security Holders......    22
  Part II
   5.         Market for Registrant's Common Equity and Related
              Stockholder Matters .....................................    23
   6.         Selected Consolidated Financial Data ....................    24
   7.         Management's Discussion and Analysis of Financial
              Condition and Results of Operations .....................    25
  7a.         Quantitative and Qualitative Disclosures about Market
              Risk ....................................................    27
   8.         Financial Statements and Supplementary Data .............    27
   9.         Changes in and Disagreements with Accountants on
              Accounting and Financial Disclosure .....................    28
  Part III
  10.         Directors and Executive Officers of the Registrant ......    29
  11.         Executive Compensation ..................................    31
  12.         Security Ownership of Certain Beneficial Owners and
              Management ..............................................    34
  13.         Certain Relationships and Related Transactions ..........    35

  Part IV
  14.         Exhibits, Financial Statements, and Reports on Form
              8-K .....................................................    35
              Signatures ..............................................    36
</TABLE>

                                       i
<PAGE>

                                    PART I


ITEM 1. BUSINESS

     Celgene  Corporation,  a  Delaware  Corporation incorporated in 1986, is an
independent  biopharmaceutical  company  engaged  primarily  in  the  discovery,
development  and  commercialization of orally administered, small molecule drugs
for  the  treatment  of cancer and immunological diseases. The key mechanisms of
action  for  our  drugs  are  modulation  of  the  overproduction  of  TNF-- and
inhibition  of angiogenesis. Additionally, our chiral chemistry program develops
chirally  pure  versions  of  existing  compounds  for  both  pharmaceutical and
agrochemical markets. We had total revenues of $26.2 million in 1999.

     The  FDA  approved  our first commercialized product, THALOMID, for sale in
the  United States in July 1998. The approved indication for THALOMID is for the
treatment  of  acute  cutaneous  manifestations of moderate to severe ENL and as
maintenance  therapy  for  prevention and suppression of cutaneous manifestation
recurrences.  ENL  is  an  inflammatory  complication  of  leprosy. We sell this
product  in  the United States through our 60 person sales and commercialization
organization.

     Our  pipeline  of  new  drugs  is  highlighted  by  two  classes  of orally
administered  therapeutic  agents: IMiDs and SelCIDs. The IMiD class is based on
the  activity  of  THALOMID  in  modulating  the  overproduction  of  TNF--  and
inhibiting  angiogenesis.  In preclinical studies, our IMiDs have demonstrated a
higher  level  of  activity  than thalidomide. In animal models, these compounds
did  not  cause  birth  defects  or sedation. We completed Phase I trials in the
fourth  quarter  of  1999  for each of our lead IMiDs. The results, announced in
February,  2000,  found  that  both  IMiDs  were well-tolerated in healthy human
volunteers.

     The  second  class  of compounds, SelCIDs, is designed to modulate TNF-- by
selectively  inhibiting  PDE  4,  a  key  cell-signaling enzyme. Our SelCIDs are
targeted  to  control  inflammation  without  broad  suppression  of  the immune
system.  Phase I trials demonstrated our lead SelCID compound, CDC 801, was safe
and  well  tolerated.  There  were  no  signs of nausea or vomiting, common side
effects  of known PDE 4 inhibitors. CDC 801 is being tested in a Phase II pilot,
placebo  controlled  trial  for  the treatment of Crohn's disease. This trial is
expected to be completed in the first half of 2000.

     In  the  third  quarter of 1999, we announced favorable clinical results of
two  Phase  III pivotal efficacy trials for ATTENADE, a chirally pure version of
dl-methylphenidate.   dl-methylphenidate   is   commonly  marketed  as  Ritalin.
ATTENADE  is  designed  to  treat the symptoms of Attention Deficit Disorder, or
ADD  and  Attention  Deficit Hyperactivity Disorder, or ADHD. We expect that the
final  12-month  safety trial will be completed in the first half of 2000 and we
plan to submit an NDA to the FDA in the second half of 2000.


                                       2
<PAGE>

CELGENE PRODUCT OVERVIEW

     The  target  disease states for, and clinical trial status of, THALOMID and
our  products  and  compounds  currently  under  development are outlined in the
following table:


<TABLE>
<CAPTION>
  PRODUCT              INDICATION/INTENDED USE                              STATUS
- ----------   ------------------------------------------   -----------------------------------------
<S>          <C>                                          <C>
THALOMID     Erythema Nodosum Leprosum (ENL)              Approved
             Multiple Myeloma                             Phase II trial data published and
                                                          presented at the American Society of
                                                          Hematology. Phase III pivotal trial
                                                          protocol in preparation.
             Myelodysplastic Syndrome                     Phase II trial ongoing and initial data
                                                          presented at the American Society of
                                                          Hematology.
             Leukemia                                     Multiple Phase II trials underway.
             Glioblastoma(1)                              Initial Phase II trials completed. Other
                                                          Phase II trials underway.
             Liver Cancer                                 Phase II trial underway.
             Kidney Cancer                                Phase II trial underway.
             Prostate Cancer(1)                           Initial Phase II trial completed. Other
                                                          Phase II trials underway.
             Kaposi's Sarcoma(1)                          Phase II trial completed.
             Cancer Cachexia                              Initial Phase II trial completed.
             Sarcoidosis                                  Initial Phase II trial completed. Other
                                                          Phase II trials underway.
             Scleroderma                                  Initial Phase II trial completed.
             Recurrent Aphthous Stomatitis                Phase III pivotal trial completed in
                                                          AIDS patients.
             Crohn's disease                              Phase II trial completed and initial
                                                          data published.
             Ulcerative Colitis                           Phase II trial underway.
             Colon and Rectal Cancer(1)                   Phase II trial announced.
SelCIDs
 CDC 801     Crohn's disease                              Phase II trial underway.
 CC 7085     Crohn's disease                              Preclinical toxicology.
IMiDs
 CDC 501     Blood cancers                                Initial Phase I trial completed.
 CC 4047     Blood cancers                                Initial Phase I trial completed.
ATTENADE     Attention Deficit Disorder and Attention     Phase III pivotal efficacy trials
             Deficit Hyperactivity Disorder               completed. Phase III safety trials
                                                          ongoing.
</TABLE>

- ----------
(1) At least one study supported by the National Cancer Institute



                                       3
<PAGE>

OVERVIEW OF ONCOLOGY AND IMMUNOLOGY

     Our  clinical  and  commercial  focus  is  to produce a portfolio of highly
potent,  selective  drugs that have the potential to regulate the overproduction
of TNF-- and are anti-angiogenic.

     TNF--,  produced primarily by certain white blood cells, is one of a number
of  proteins  called  cytokines  that  act as chemical messengers throughout the
body  to  regulate  many  aspects  of  the  immune system. TNF-- is essential to
mounting  an  inflammatory  response, which is the normal immune system reaction
to  infection or injury that rids the body of foreign agents and promotes tissue
repair.  However,  chronic  or excessive production of TNF-- has been implicated
in  a  number  of acute and chronic inflammatory diseases. These disease states,
which  are  inadequately  treated  with  existing therapies, include non-insulin
dependent  diabetes, Alzheimer's disease, congestive heart failure, inflammatory
bowel  disease,  rheumatoid  arthritis,  cancer  cachexia,  Parkinson's disease,
multiple sclerosis and lupus.

     Traditional  therapies  for  these disease states include anti-inflammatory
drugs  and  immunosuppressive  agents.  These  therapies  often  fail to achieve
significant  clinical benefits and can cause serious side effects such as severe
drops   in   certain  blood  component  counts,  liver  toxicity,  osteoporosis,
teratogenicity  and  various  endocrine abnormalities. We believe that selective
control  and reduction of TNF-- represents a promising new strategy for treating
chronic  inflammatory  diseases.  In pursuit of this strategy, two broad classes
of compounds have been investigated: proteins and small synthetic molecules.

     Anti-TNF--  proteins,  including  anti-TNF--  antibodies  and TNF-- soluble
receptors,   have  demonstrated  efficacy  in  the  treatment  of  such  chronic
inflammatory  diseases  as  rheumatoid  arthritis  and  Crohn's  disease.  While
initial  doses  of  these  anti-TNF-- proteins have been well tolerated and have
reduced  disease  activity  in  clinical studies, these proteins exhibit certain
shortcomings  linked  to  their  nature  as  proteins.  First,  they  are  large
molecules  that  must  currently  be  injected or infused. Second, the period of
efficacy  of  a  given  dosage of a protein-based drug can decline with repeated
administration,  rendering  protein-based  drugs  more suitable for treatment of
acute   pathological   conditions  rather  than  chronic  disease  states.  This
limitation  is due in part to increasing production by a patient's immune system
of antibodies that neutralize administered proteins.

     There  are  a  number of large molecule, protein-based therapeutic products
under  development  by  other  companies  for  TNF-- modulation. One product has
received  approval  from  the  FDA  for  the  treatment  of  Crohn's disease and
rheumatoid   arthritis,   and  another  has  received  approval  for  rheumatoid
arthritis.  Synthetic  small molecule drugs, however, if successfully developed,
may  prove  to  be preferable in the treatment of chronic inflammatory diseases,
due  to  factors  such  as  oral  dosing, lower cost of therapy and avoidance of
undesirable  immune  response  that  results in adverse side effects and reduced
efficacy.  We  believe  that our small molecule immunotherapeutic compounds have
the potential to selectively modulate TNF-- while affording these benefits.

     In   addition,  research  has  indicated  that  our  small  molecule  drug,
THALOMID,   is  anti-angiogenic.  Angiogenesis  is  the  fundamental  biological
process  by  which new blood vessels are formed. Cancer cells require oxygen and
nutrients  and  initiate  a  biochemical  mechanism that stimulates angiogenesis
which,  in  turn,  provides  the cancerous cells with the blood supply that they
need  to  grow. Inhibition of angiogenesis could adversely affect the graft of a
tumor  and  be  a potential anti-cancer therapy. This therapy could be also used
in  conjunction  with  radiation  or  more  traditional chemotherapeutic agents.
Currently,  a  number  of anti-angiogenic agents are being developed by a number
of  companies.  However,  we  believe  that  THALOMID is the only product on the
market  that has a direct anti-angiogenic effect. Moreover, preliminary research
suggests  that our two new classes of small molecule immunotherapeutic compounds
- -- one of which is based on thalidomide's activity -- may be anti-angiogenic.


                                       4
<PAGE>

THALOMID

     In  July 1998, we received FDA approval to market THALOMID for treatment of
ENL  and  the product was launched in late September 1998. THALOMID is the first
drug  approved  under  a special "Restricted Distribution for Safety" regulation
and  is  distributed  through our S.T.E.P.S. program. Our program is designed to
support  the  safe  and  appropriate use of THALOMID and has been made a part of
the  approved  labeling  for  THALOMID. We are currently developing THALOMID for
the  treatment of a variety of serious disease states for which we believe there
are  currently no adequate approved therapies. Our current intent is to seek FDA
approval  for  THALOMID  for  at least one cancer of the blood, such as multiple
myeloma, one solid tumor cancer and an AIDS-related indication.

     The  immunological  and  anti-angiogenic  properties  of THALOMID are being
investigated  as  the  basis for treatment of a variety of oncological diseases,
and  a  number  of  trials  are  ongoing,  some  in cooperation with the NCI, to
evaluate  the  potential  of  the  drug  in  cancer.  Key investigations include
multiple  myeloma,  which  was  the  subject  of an article and editorial in the
November  18,  1999  issue  of  The New England Journal of Medicine, Volume 341,
Number  21,  and  glioblastoma multiforme, for which initial data were presented
in  November  1999  at  the  Chemotherapy Foundation Symposium XVII in New York.
Additional  presentations  have  been made at the 41st ASH Symposium in December
1999.

     Our   work   with   thalidomide   was  originally  based  on  a  scientific
collaboration   with   The   Rockefeller  University's  Laboratory  of  Cellular
Physiology  and  Immunology.  In the early 1990s, researchers at The Rockefeller
University  discovered  that  thalidomide is a selective modulator of TNF-- and,
therefore,  could be of potential benefit in many serious immune-related disease
states,  including  cachexia and other AIDS-related conditions. We believe that,
in  serious and debilitating disease states, the risk of birth defects and other
potential  side  effects  related  to  thalidomide  is  outweighed by the drug's
potential  clinical  benefits.  The  Rockefeller  University  has  granted to us
certain  exclusive  rights and licenses to manufacture, use and sell thalidomide
for  treating  the  toxicity  associated  with  high  concentrations of TNF-- in
septic  shock,  cachexia  and  HIV-related  disease  states.  Researchers at the
Children's   Medical  Center,  which  is  affiliated  with  Harvard  University,
discovered  that  thalidomide  is  anti-angiogenic  and  filed  patents  on this
utility.  These patents, some of which have not issued in the United States, are
exclusively  licensed  to EntreMed, Inc. We were granted an exclusive sublicense
to all of EntreMed's thalidomide patents in December 1998.

     As  a  result  of  our  own  applications  and  designations  acquired from
EntreMed,  we  now  have  Orphan  Drug  designations  from  the FDA for THALOMID
covering:  primary  brain  malignancies; HIV associated wasting syndrome; severe
Recurrent    Aphthous    Stomatitis,    or    RAS,   in   severely,   terminally
immunocompromised  patients; clinical manifestations of mycobacterial infections
caused  by  Mycobacterium  tuberculosis  and  non-tuberculous mycobacteria; ENL;
multiple  myeloma; Crohn's disease and Kaposi's sarcoma. If the FDA approves any
of  these  indications  for  THALOMID, we will be granted a seven-year period of
exclusivity  during  which  time  the  FDA  is  prohibited,  except  under  some
conditions,  from  approving  another  version  of  thalidomide for the approved
indication.

     Thalidomide  was  developed  initially  as  a sedative, and was also widely
prescribed  by  doctors  in Europe in the late 1950s and early 1960s to pregnant
women  for  relief  of  morning  sickness. After severe birth defects were later
observed  with  use of the drug, it was virtually removed from the world market.
Thalidomide  was  later  discovered to have therapeutic effects in the treatment
of  ENL, a disease that is rare in the United States but common in many parts of
the  developing  world.  Although  the  FDA  had never approved the marketing of
thalidomide,  the  U.S.  Public  Health  Service  has dispensed the drug for the
treatment  of  ENL for the past 25 years. We note that thalidomide's history may
limit market acceptance of THALOMID.


ONCOLOGY

     Cancer  tissue  has  many  blood  vessels.  This observation has led to the
realization  that  growth  of  blood  vessels  is  essential  for  tumor growth,
invasion  and  metastasis.  Specifically,  developing  solid  primary tumors are
believed  to  remain  clinically insignificant unless they can arrange to obtain
nourishment  from  their host. Biochemically, an invasive tumor acts by altering
a complex system of factors causing the


                                       5
<PAGE>

formation  of new blood vessels from existing ones. Almost three decades ago, it
was  proposed  that this tumor angiogenesis could be a target of cancer therapy.
Anti-angiogenic  compounds  were  believed  to  be  able  to work by reducing or
halting  remaining  tumor growth and could also be used in conjunction with more
traditional   chemotherapeutic   agents.   Thalidomide   was  discovered  to  be
anti-angiogenic at the Children's Medical Center in Boston.

     We   are   currently  working  with  the  NCI  and  a  number  of  clinical
investigators  to  assess  the potential of THALOMID in the treatment of various
cancers.  In the first 12 months after THALOMID was commercially launched in the
United  States,  approximately  70%  of  the  product's  prescriptions  were  in
oncology,  as  reported  by  prescribers  on  our  S.T.E.P.S. program enrollment
surveys.

     Multiple  Myeloma.  Multiple myeloma is a malignant proliferation of plasma
cells  and  plasmacytoid  cells.  It  is  the  second  most  common  blood borne
malignancy  and  is  invariably  fatal.  According  to  the  Leukemia Society of
America,  multiple  myeloma  accounts  for  about 13% of blood borne disease and
affects  approximately 40,000 people in the United States. The incidence of this
disease  is  approximately  four per 100,000, and approximately 14,400 cases are
reported  annually  with approximately 11,000 deaths associated with the disease
every year.

     Clinical  research  published  in  the November 18, 1999 edition of The New
England  Journal of Medicine, Volume 341, Number 21, reported results of a study
conducted  at  the  University of Arkansas on the use of THALOMID in 84 multiple
myeloma  patients  with  advanced stage disease and histories of extensive prior
chemotherapeutic  interventions,  radiation  treatments and multiple bone marrow
transplants.  This  Phase  II study found that 32% of the patients had a partial
response  and  10%  of  the patients had a complete or nearly complete remission
based  on decreases in paraprotein, the myeloma protein in serum, or Bence Jones
protein  in urine, important markers of the progression of the disease. Clinical
data  from  180  patients  in  this study was presented at the December 1999 ASH
meeting  by  researchers  at the University of Arkansas who reported that 36% of
the  patients  achieved  a  25%  reduction  in  tumor  burden. Eighteen patients
achieved  paraprotein  response of at least 90%, 14 patients achieved at least a
75%  paraprotein  response,  16  patients  achieved  at  least a 50% paraprotein
response  and  four patients achieved a complete response. Side effects reported
by  the  investigators  were  constipation,  weakness/fatigue  and somnolence. A
number  of  additional presentations and posters presented confirmatory evidence
at  the  ASH  meeting  regarding  the  efficacy  of THALOMID. In September 1999,
similar  findings  were  reported  at  the  International  Myeloma  Workshop  in
Stockholm,  Sweden  on  trials  conducted  at  Cedars-Sinai  Medical Center, Los
Angeles.  In  this  Phase  II,  open  label study of 20 relapsing or progressive
multiple  myeloma  patients  utilizing  low-dose  THALOMID  administered over an
eight-week  trial  period,  30%  of  patients  experienced  a  greater  than 50%
reduction  of tumor burden. Further data confirming earlier trials was presented
at  the  Chemotherapy  Foundation Symposium XVII in November 1999 in New York on
15  refractory  patients  treated at Saint Vincent's Medical Center, New York in
which  there  was  observed  a  67%  overall  response with THALOMID alone or in
combination with chemotherapy.

     In  the  12  months  following  the  launch  of  THALOMID,  as  reported by
prescribers  on  our S.T.E.P.S. program enrollment surveys, approximately 30% of
total  usage  was  in  multiple  myeloma.  Based  on this information and on the
growing   volume   of   clinical   trial   data,   our  plan  is  to  develop  a
regulatory/clinical  program  based  on what has been learned from these studies
and  file a supplemental NDA for THALOMID for the treatment of multiple myeloma.


     Glioblastoma  Multiforme.  Glioblastomas  are  the most common brain tumors
and  account  for  50%  of  all gliomas, an aggressive form of brain cancer. The
usual  treatment of high-grade gliomas is surgical removal followed by radiation
therapy.

     Studies  at  the  New  York  University  School of Medicine and at the Dana
Farber  Institute have demonstrated the potential for thalidomide as a treatment
for  glioblastoma multiforme. Phase I/II data from the New York University trial
were  presented  in  November 1999 at the Chemotherapy Foundation Symposium XVII
in  New  York.  THALOMID  in combination with carboplatin was administered to 71
patients  with  recurrent glioblastoma multiforme. At the maximum tolerated dose
of  THALOMID,  53  of  the  patients  were  evaluated  for  efficacy,  with  70%
experiencing responses, two with partial responses, 35


                                       6
<PAGE>

with  disease  stabilization.  The  trial's  most commonly reported side effects
were  constipation  and  drowsiness.  A  Phase  III  trial  will  assess whether
patients  benefited  because of the higher carboplatin doses or if there was any
synergy  between thalidomide and carboplatin. Additionally, a Phase II trial has
been  initiated in collaboration with the NCI's Radiation Therapy Oncology Group
to  investigate  the  effect  of  THALOMID  and  radiation as co-therapy for the
treatment of glioblastoma.

     Other  Oncology  Indications.  In  addition to glioblastoma multiforme, the
NCI  is  currently  investigating  THALOMID  in  clinical  trials  on  prostate,
colorectal,  head  and neck and non-small cell lung cancer. Other trials such as
those  in  liver  cancer,  kidney  cancer  and  leukemia  are  being  run by key
investigators.   Recently,  researchers  in  London  reported  that  continuous,
low-dose  thalidomide is useful as an agent in patients with advanced cancers as
a  palliative.  That  study  showed that three of 18 patients with kidney cancer
also  showed  a  response  benefit and three patients had stabilization of their
disease  for  periods  of  up  to  six  months. In addition, four of 17 melanoma
patients  experienced stable disease for up to six months. According to a report
in  the  medical  journal Lancet, follow-up studies using higher doses have also
shown  "encouraging  results"  in patients with kidney cancer. These researchers
are  now  testing thalidomide in combination with interferon or interleukin 2 in
this  group. Similarly, the NCI reported trial results in which 63 patients were
treated  with either a low dose or a high dose of thalidomide. Approximately 53%
of  the  low  dose  and  68%  of the high dose patients had declines in prostate
specific  antigen, a recognized marker for prostate cancer. If successful, these
studies  would establish proof of principle, leading to the design of additional
trials, including pivotal studies.

IMMUNOLOGY

     THALOMID  has  been  shown to impact the immune system both in vitro and in
vivo.  Examples  of  such biological activities include the inhibition of TNF--,
stimulation  of  the  anti-inflammatory  cytokine IL-10 and activation of T-cell
function.  These  types of activities could prove to have therapeutic benefit in
a  variety  of  inflammatory,  infectious  and  autoimmune diseases. The two key
areas  of  investigation  at  present  involve  inflammatory  bowel  disease and
serious  complications  associated  with  HIV/AIDS.  In addition, other areas of
investigation  include  sarcoidosis,  an inflammation of body tissue which often
attacks the lungs and lymph nodes, and scleroderma, a chronic tissue disorder.

     Erythema  Nodosum  Leprosum.  ENL  is  a complication of leprosy, a chronic
bacterial  disease.  Although  the  disease  is  relatively  rare  in the United
States,  leprosy afflicts millions worldwide. ENL occurs in about 30% of leprosy
patients  and  is  characterized by cutaneous lesions, acute inflammation, fever
and  anorexia.  On  July  16,  1998, we received approval from the FDA to market
THALOMID for the treatment of ENL.

     Inflammatory   Bowel   Disease.   According  to  the  Crohn's  and  Colitis
Foundation  of  America,  there  are  approximately  one  million Americans with
active  inflammatory  bowel disease. Inflammatory bowel disease is characterized
by  serious chronic inflammation of the wall or any part of the gastrointestinal
tract  and  results  in  pain,  bloating  and diarrhea. In addition, the chronic
inflammation  may  result  in  abscesses and fistula formation. The most serious
form  of  inflammatory  bowel  disease  is  known  as  Crohn's  disease  with an
estimated  70,000  to  125,000  U.S.  patients diagnosed with active moderate to
severe manifestation of the disease.

     A  Phase  II  pilot  study  using  THALOMID in patients with severe Crohn's
disease  has been concluded at the Cedars-Sinai Medical Center, Los Angeles, and
reported  in  the  journal Gastroenterology. About 70% of the patients suffering
from  moderate  to  severe  Crohn's disease who completed at least five weeks of
the  12-week  trial demonstrated a response when treated with low dose THALOMID,
with  20%  of  these  patients experiencing remission. All patients were able to
reduce   their   steroid   regimen  by  at  least  50%,  with  44%  of  patients
discontinuing  steroids. Data from this trial suggests that THALOMID may provide
clinical  benefit  and  potentially  reduce the need for steroid treatment. This
combination  of effects could mean improvement over current therapeutic options.
A  similar  Phase  II  pilot  study  has  been initiated at Cedars-Sinai Medical
Center  using  THALOMID  for  chronically  active  ulcerative  colitis, which is
another  form  of  inflammatory  bowel  disease.  Estimates of the prevalence of
ulcerative  colitis  in  the  United  States generally range between 250,000 and
500,000.  Recent  preliminary  data  has  shown  that  eight of 11 patients with
intractable bowel disease benefited from THALOMID.


                                       7
<PAGE>

     HIV/AIDS.  Recurrent Aphthous Stomatitis, or RAS, is a complication of AIDS
characterized  by  lesions  of  the  oral cavity, esophagus and gastrointestinal
tract  and  may  interfere with normal eating. We believe RAS currently afflicts
an  estimated  5,000  AIDS  patients in the United States. Positive results have
been  reported  in  a  study  conducted by the AIDS Clinical Trials Group of the
National  Institutes  of  Health using a formulation of thalidomide manufactured
by  a  third  party. In mid-1997, we began a pivotal clinical trial involving 84
patients  for the evaluation of THALOMID in the treatment of RAS, using the same
principal  investigator  as  the  AIDS  Clinical  Trials Group study. We will be
analyzing  this  clinical  trial data in 2000 with a view toward the possibility
of a supplemental NDA submission to the FDA.

S.T.E.P.S. PROGRAM

     Working  with  the  FDA  and other governmental agencies as well as certain
advocacy  groups,  we  designed  and  implemented  our  S.T.E.P.S.  program, the
objective   of  which  is  the  safe  and  appropriate  use  of  THALOMID.  This
proprietary  program  includes  comprehensive  physician, pharmacist and patient
education.  Female  patients  are  required  to  use contraception and are given
pregnancy  tests regularly. All patients are also subject to other requirements,
including   informed  consent  and  participation  in  a  confidential  outcomes
registry  managed  on  our  behalf  by  an academic epidemiology research group.
Physicians  are  also  required  to  comply  with the educational, contraception
counseling,  informed  consent  and  pregnancy testing and other elements of the
program.  Dispensing pharmacists are required to confirm that the physician is a
registered  participant  in  the  program,  and  that  the patient has signed an
informed  consent.  Automatic  refills  are  not permitted under the program and
each  prescription  may  not  exceed  four  weeks  dosing. A new prescription is
required each month.

SALES AND COMMERCIALIZATION

     We  have  established  an  organization of approximately 60 persons to sell
and  commercialize  THALOMID.  These individuals have considerable experience in
the  pharmaceutical  industry  and  many  have  experience  with oncological and
immunological   products.   We   expect   to   expand  our  THALOMID  sales  and
commercialization  group to support products we develop to treat oncological and
immunological  diseases.  We  intend  to market and sell the products we develop
for  indications with accessible patient populations. For drugs with indications
with   larger   patient   populations,   we  anticipate  partnering  with  other
pharmaceutical  companies.  In  addition,  we  are  positioned to accelerate the
expansion  of  these sales resources as appropriate to take advantage of product
in-licensing  and  product  acquistion  opportunities.  We  intend  to establish
commercial  relationships  with  selected companies in other countries to market
THALOMID.

MANUFACTURING

     THALOMID  is  formulated  and  encapsulated  for us by Penn Pharmaceuticals
Ltd.  of  Great  Britain  in an FDA approved facility devoted exclusively to the
production  of  THALOMID  capsules.  Both  the  bulk manufacturing facility that
produces  the  drug  substance  for  THALOMID  and  the  Penn facility have been
certified  as  cGMP  compliant. In certain instances, we may be required to make
substantial  capital  expenditures  to access additional manufacturing capacity.
In  addition,  we  have  established a contract with another cGMP certified bulk
drug  substance  supplier  for  THALOMID  that  will  begin  in  2001  once  the
regulatory  process  is  completed.  We  are  also actively seeking an alternate
manufacturer   to   provide   additional   capacity   for  the  formulation  and
encapsulation of THALOMID and expect that this will be concluded in 2000.

IMIDS

     We  have designed and synthesized a number of novel structural analogues of
thalidomide  called  IMiDs  which have been demonstrated in in vitro tests to be
substantially  more potent than thalidomide. There can be no assurance, however,
that  the  same effect can be duplicated in humans. Animal models have suggested
that  our  IMiDs  do  not  cause  the birth defects associated with thalidomide.
Research  on  these  compounds  has identified two clinical trial candidates and
each  has  completed  a Phase I trial. Research continues on follow-on compounds
with enhanced immunological and anti-angiogenic activity.


                                       8
<PAGE>

IMiDs  may have potential for treating conditions where there is a deficiency in
T-cell  activity,  such as viral diseases including HIV-related diseases, or for
enhancing   potential  IL-12  mediated  anti-tumor  activities.  In  preclinical
studies,  our  lead IMiD compound has been shown to inhibit interleukins 1-beta,
6  and  12  while stimulating the production of interleukins 10 and 2 as well as
interferon  gamma.  The  activity  of  T-cells is enhanced by the compound up to
1,000  times more than with thalidomide. We expect to advance our lead IMiD, CDC
501,  into a Phase II pilot trial in a blood cancer during 2000. The U.S. Patent
and  Trademark  Office  has  issued  composition of matter and use patents to us
relating to our IMiDs.

SELCIDS

     We  have  designed, synthesized and tested a large number of SelCIDs. These
compounds  have  demonstrated  the  ability  to be highly specific inhibitors of
TNF--  overproduction  in  in  vitro bioassays of human cells. SelCIDs appear to
have   a   specific  inhibitory  effect  on  PDE  4,  which  is  linked  to  the
overproduction  of  TNF--.  Studies  have  determined  that  many of the SelCIDs
decrease  synthesis  of TNF-- through selective inhibition of PDE 4. Preclinical
and  animal  tests  have  shown this class of compounds to be up to 10,000 times
more  active  with  a longer half-life than THALOMID. We believe that control of
TNF--  at  its  source,  versus  simple  removal  of  circulating  levels of the
cytokine,  may  facilitate  more  effective  therapy without immune suppression.
There  can  be  no assurance, however, that the same effect can be duplicated in
humans.

     Our  lead  SelCID,  CDC  801, was found to be well tolerated in two Phase I
trials  completed in 1999 in the United Kingdom. A Phase II pilot trial for this
compound  in  Crohn's  disease  commenced  in  1999  at the Cedars-Sinai Medical
Center  and  results  are  expected  in  the first half of 2000. In addition, we
expect  to  initiate a Phase II pilot trial for CDC 801 in a blood cancer during
2000.  Other  SelCIDs  have  been  identified  and the most advanced of these is
undergoing  toxicological  evaluation in preparation for the initiation of Phase
I  trials.  Unlike many therapeutics which inhibit PDE 4, SelCIDs have not shown
any  evidence  of  acute  nausea  and  vomiting in patients. The U.S. Patent and
Trademark  Office  has  issued  to  us  composition  of  matter  and use patents
relating to our SelCIDs.

CHIRAL CHEMISTRY

     Many  human  pharmaceuticals  and  agrochemicals  exist  in  two  different
three-dimensional  configurations  that  are identical in chemical structure but
are  mirror  images of each other. These conformations, known as enantiomers, or
isomers,  generally  interact  differently  with biological targets. In clinical
applications,  one  isomer  may  result  in  the  desired  therapeutic effect by
stimulating  or  inhibiting  a  targeted  biological  function,  while the other
isomer  may  be  inactive  or  cause  undesirable  side  effects. In contrast to
racemic  compositions  which  contain  both  isomers,  the  use of chirally pure
pharmaceuticals  can  result  in  significant  clinical benefits such as reduced
toxicity  and  increased  efficacy.  In  agrochemical  applications,  the use of
chirally  pure chemicals can result in a substantially reduced volume of product
required   to   achieve   the  desired  benefit,  thereby  potentially  lowering
manufacturing  costs  and  reducing  the  environmental  burden as compared with
racemic chemicals.

     Our  biocatalytic process enables the efficient production of chirally pure
compounds.  This  patented  process  is  based  primarily  on the use of enzymes
called  aminotransaminases,  which  are  optimized  by  us  through a variety of
techniques  including genetic engineering. These enzymes catalyze the production
of  only  the  desired  stereoisomer  of  a  chiral  compound and can be used in
conventional chemical synthesis reactors at room temperature.

     Our  biocatalytic  process  for  producing  chirally pure compounds differs
from  the  more  common  approach  of  producing  racemic  mixtures  followed by
separation  of  the  desired  stereoisomer through resolution techniques such as
crystallization  or  chromatography.  These  traditional approaches to producing
chirally   pure   compounds  can  be  cumbersome,  result  in  low  yields,  use
substantial  amounts  of  raw  materials  and  involve  the disposition of waste
product.  Traditional  approaches  also  are  generally less economical than our
process.  We  believe  that  our  biocatalytic  process  can  be  applied to the
manufacture of a wide variety of organic chemicals.


                                       9
<PAGE>

     We  believe  there  is  a significant incremental opportunity in developing
selected,  chirally  pure  versions  of approved drugs currently sold in racemic
form.  Compounds that have been approved and marketed have a significant body of
information regarding their safety and efficacy and consequently:

   - the  cost  and  duration of preclinical evaluations and clinical trials may
     be  reduced  if  reference  may  be  made  to  data  used  in the course of
     obtaining regulatory approval for the racemic parent compound;

   - the risk of not obtaining regulatory approval may be reduced; and

   - marketing risks may also be reduced due to the  established  market for the
     parent compound.

     We  have made significant progress over the past year in the development of
ATTENADE,  the  chirally  pure version of Ritalin. We have also made significant
progress  in  the  development and production of chirally pure agrochemicals. We
believe  that the agrochemical market presents a substantial opportunity because
many  agrochemicals  produced  in racemic form could be manufactured in chirally
pure form.

ATTENADE

     We  have  completed  two  pivotal  Phase  III efficacy trials for ATTENADE.
These  trials  found  that  ATTENADE met all efficacy parameters for controlling
symptoms   of   ADD   and   ADHD   in   school-age  children.  Drugs  containing
dl-methylphenidate  such as Ritalin have been used for decades for the treatment
of  ADD and ADHD. We believe that one million children in the United States were
treated  with  dl-methylphenidate and other psychostimulants in 1998. Total U.S.
sales  in  1998  of  drugs  used  to  treat  the  symptoms  of ADD and ADHD were
approximately $500 million.

     More   than   200   children  participated  in  our  pivotal  trials.  Both
multi-center  trials  compared  ATTENADE  to  placebo; the second trial directly
compared  the  efficacy  of  both ATTENADE and dl-methylphenidate to placebo. As
compared  to  placebo,  ATTENADE demonstrated a statistically significant longer
duration  of action than dl-methylphenidate. ATTENADE controlled the symptoms of
ADD  and  ADHD  at  all times measured in the study while dl-methylphenidate did
not  control  the  symptoms  at the last measurement. In both trials, behavioral
and  objective  measures  were  examined.  ATTENADE  had  favorable  scores over
dl-methylphenidate  in  all  parameters  measured.  The  results  of the primary
efficacy  analysis indicated that ATTENADE was significantly more effective than
placebo  as  evaluated  by  a behavioral scale, signifying an improvement in the
clinical  status  of the children. The results of the second trial confirmed the
drug's  efficacy  and  indicated  a  significantly longer duration of action for
ATTENADE  compared  to dl-methlyphenidate as measured by a behavioral scale. The
Phase  III safety trial is scheduled for completion in the first quarter of 2000
and  an  NDA  submission  is anticipated later in the year. Clinical trials on a
pulsed release formulation are planned to commence in the first half of 2000.

     We  are  in  discussions  regarding partnerships for ATTENADE in the United
States  and  Europe.  In  Canada, where it is awaiting registration, ATTENADE is
licensed  to  Biovail Corporation, which purchased $2.5 million dollars worth of
our  stock  and will pay to us licensing fees, milestone payments and royalties.
We  have  been  issued  patents for the use of ATTENADE for the treatment of ADD
and  ADHD,  and  for the once-a-day administration of methylphenidate drugs in a
controlled  or  pulsed  release formulation that includes both the chirally pure
d-methylphenidate  and  the  racemic  form.  In  addition,  we  have been issued
process patents covering our manufacturing process for the active substance.

CHIRALLY PURE AGROCHEMICALS

     Celgro  is  applying  our  proprietary biocatalytic synthesis technology to
agrochemicals.  Celgro's  approach  is  to  work  with agrochemical companies to
adapt  our  biocatalytic technology to the manufacture of chirally pure versions
of  their  existing  crop  protection product and then license the technology to
these  companies  in  exchange  for  royalties. Celgro will also seek to develop
chirally  pure versions of existing agrochemicals on its own and then enter into
license  agreements  with  third  parties,  who  would  manufacture and sell the
agrochemicals. We expect that these arrangements typically will


                                       10
<PAGE>

include  milestone  payments, reimbursement of research and development expenses
and  royalty  arrangements.  We  have  entered  into  research  and  development
agreements  with two leading agrochemical companies and initiatives are underway
to secure additional collaborations.

     We  also believe that our chiral technology can be enabling in agrochemical
applications  because  it has the potential to significantly lower manufacturing
costs  compared  to  conventional  technologies  and  other chiral technologies.
Compared  to  our  biocatalytic  process, conventional technologies require more
raw  materials and greater plant capacity to produce the same effective quantity
of  product, while other chiral technologies require specialized equipment, more
expensive  chiral  agents,  more  raw material and greater capacity for handling
hazardous  wastes  produced  in  the  separation  process.  In  addition,  it is
anticipated  that  the required application amount of a chirally pure form of an
agrochemical  could  be substantially less than the racemic form and achieve the
same  or  better  results,  thereby reducing environmental burden. Agrochemicals
are  highly  price  sensitive  and,  therefore, a process that produces chirally
pure products at significant cost savings could be in substantial demand.

PATENTS AND PROPRIETARY TECHNOLOGY

     Patents  and  other proprietary rights are important to our business. It is
our  policy  to seek patent protection for our inventions, and also to rely upon
trade  secrets,  know-how,  continuing  technological  innovations and licensing
opportunities to develop and maintain our competitive position.

     Under  an  agreement  with  The  Rockefeller  University,  we have obtained
certain  exclusive  rights  and  licenses to manufacture, have manufactured, use
and  sell  products that are based on compounds that were identified in research
carried  out by The Rockefeller University and us, that have activity associated
with  TNF(alpha).  The  Rockefeller  University has identified a method of using
thalidomide  and  certain  thalidomide-like  compounds to treat certain symptoms
associated   with   abnormal   concentrations  of  TNF(alpha),  including  those
manifested   in   septic  shock,  cachexia  and  HIV  infection.  In  1995,  The
Rockefeller  University was issued a U.S. patent which claims such methods. This
U.S.  patent  expires  in  2012 and is included in the patent rights exclusively
licensed  to  us under the license from The Rockefeller University. However, The
Rockefeller  University  did not seek corresponding patents in any other country
in   respect  of  this  invention.  The  Rockefeller  University  has  filed  an
additional  U.S.  patent  application  and  an  international patent application
relating  to  the  activity  of thalidomide related to interleukin-12. Under the
license  from  The  Rockefeller  University,  we  were  obligated to pay certain
specified  royalties  to  The  Rockefeller  University  on net sales of licensed
products  for  covered  indications.  In  November  1999,  we  agreed  with  The
Rockefeller  University to substitute a lump sum payment and issue stock options
to  The  Rockefeller  University  and  the  inventors  in  lieu of the royalties
previously   payable  under  the  license.  The  license  from  The  Rockefeller
University  is  coterminous  with the last to expire of the licensed patents and
is  terminable  by  The  Rockefeller University only in the event of a breach of
the  agreement's  terms  by  us  which breach shall fail to be remedied for more
than  sixty  days  after notice thereof. Any termination of the license from The
Rockefeller  University  could  have  a material adverse effect on our business,
financial condition and results of operations.

     In  1998, we were granted an exclusive sublicense to all of the thalidomide
patents  and  patent applications worldwide, exclusively licensed to EntreMed by
the   Children's   Medical  Center  Corp.,  which  is  affiliated  with  Harvard
University,  related  to  the  anti-angiogenic action of thalidomide. Three U.S.
patents  issued  to  Children's  Medical  Center  Corp.  will  expire  in  2014.
Corresponding   foreign   patent   applications   and   additional  U.S.  patent
applications  are  still  pending. Further, we have also exclusively sublicensed
pending  U.S.  and foreign patent applications related to the use of thalidomide
in  combination  with  other  therapeutic agents. There can be no assurance that
additional  patents will issue, or that if patents issue, that such patents will
provide  us with significant proprietary protection or commercial advantage. The
license  from  EntreMed  is  coterminous with the last to expire of the licensed
patents  and  we  must  pay  royalties  for  at  least  12  years from our first
commercial  sale in the United States. The EntreMed license is terminable in the
event  of  a  breach  by  us, which breach shall fail to be remedied for 60 days
after  notice thereof. Any termination of the license from EntreMed could have a
material  adverse  affect  on  our  business, financial condition and results of
operations.


                                       11
<PAGE>

     We  have  been  issued  a  total  of  36  U.S.  patents  and  have filed an
additional  15 U.S. patent applications. Of the issued patents, 14 relate to our
oncologic   or   immunologic   compounds  and  uses  and  six  are  directed  to
methylphenidate  therapeutic compositions and processes. Our U.S. patents expire
between  2001 and 2019. We have filed patient applications and in some instances
have  obtained  patents in certain other countries which correspond to some, but
not  all  of our U.S. patents. We expect to continue to file patent applications
covering the use of our proprietary inventions.

     Prior  to  the  enactment in the United States of new laws adopting certain
changes  mandated  by  the General Agreement on Tariffs and Trade, the exclusive
rights  afforded  by  a  U.S. patent were for a period of 17 years measured from
the  date of grant. Under these new laws, the term of any U.S. patent granted on
an  application  filed  subsequent  to June 8, 1995 will terminate 20 years from
the  date  on which the patent application was filed in the United States or the
first  priority  date,  whichever  occurs  first.  Future  patents granted on an
application  filed before June 8, 1995 will have a term that terminates 20 years
from such date, or 17 years from the date of grant, whichever date is later.

     Under  the  Drug Price Competition and Patent Term Restoration Act of 1984,
a  U.S.  product patent or use patent may be extended for up to five years under
certain  circumstances to compensate the patent holder for the time required for
FDA  regulatory  review  of  the product. The benefits of this act are available
only  to the first approved use of the active ingredient in the drug product and
may  be  applied  only to one patent per drug product. There can be no assurance
that we will be able to take advantage of this law.

     Our  success  will  depend,  in  part, on our ability to obtain and enforce
patents,  protect  trade  secrets,  obtain licenses to technology owned by third
parties   when  necessary  and  conduct  its  business  without  infringing  the
proprietary  rights  of  others.  The  patent  positions  of  pharmaceutical and
biotechnology  firms, including ours, can be uncertain and involve complex legal
and  factual questions. In addition, the coverage sought in a patent application
can  be  significantly  reduced before the patent is issued. Consequently, we do
not  know  whether any of our owned or licensed pending applications will result
in  the  issuance  of  patents  or, if any patents are issued, whether they will
provide  significant  proprietary protection or commercial advantage, or whether
they   will   be   circumvented  or  infringed  upon  by  others.  Since  patent
applications  in the United States are maintained in secrecy until patents issue
and  since  publication  of  discoveries  in the scientific or patent literature
often  lag  behind  actual  discoveries,  we  cannot  be certain that we, or our
licensors,  were the first to make the inventions covered by each of the pending
patent  applications or that we, or our licensors, were the first to file patent
applications  for  such  inventions. In the event a third party has also filed a
patent  for any of its inventions, we, or our licensors, may have to participate
in  interference proceedings declared by the U.S. patent and Trademark Office to
determine  priority  of  invention,  which  could  result  in the loss of a U.S.
patent  or  loss  of  any  opportunity  to secure U.S. patent protection for the
invention.  Even  if  the eventual outcome is favorable to us, such interference
proceedings  could  result  in  substantial  cost  to  us. Prosecution of patent
applications  and  litigation to establish the validity and scope of patents, to
assert  patent  infringement  claims against others and to defend against patent
infringement  claims by others can be expensive and time-consuming. There can be
no  assurance  that,  in  the  event that claims of any of our owned or licensed
patents  are  challenged  by  one  or  more  third  parties, any court or patent
authority  ruling  on  such challenge will determine that such patent claims are
valid  and  enforceable. An adverse outcome in such litigation could cause us to
lose  exclusivity  relating  to  the  subject  matter  delineated by such patent
claims  and may have a material adverse effect on our business. If a third party
is  found  to have rights covering products or processes used by us, we could be
forced  to cease using the products or processes covered by the disputed rights,
subject  to  significant  liabilities  to  such  third  party and/or required to
license  technologies  from  such  third  party.  Also, different countries have
different  procedures  for  obtaining  patents  and  patents issued by different
countries  provide different degrees of protection against the use of a patented
invention  by others. There can be no assurance, therefore, that the issuance to
us  in  one  country  of  a patent covering an invention will be followed by the
issuance  in  other countries of patents covering the same invention or that any
judicial  interpretation  of the validity, enforceability or scope of the claims
in   a   patent   issued  in  one  country  will  be  similar  to  the  judicial
interpretation  given  to  a  corresponding  patent  issued  in another country.
Furthermore,  even  if  our owned or licensed patents are determined to be valid
and  enforceable, there can be no assurance that competitors will not be able to
design around such patents and compete with us using the resulting alternative


                                       12
<PAGE>

technology.  We  do  not  currently  have,  nor  do  we  intend  to seek, patent
protection relating to the use of THALOMID to treat ENL.

     We  also rely upon unpatented, proprietary and trade secret technology that
we   seek   to   protect,  in  part,  by  confidentiality  agreements  with  our
collaborative    partners,    employees,    consultants,    outside   scientific
collaborators,  sponsored  researchers  and  other  advisors.  There  can  be no
assurance  that these agreements provide meaningful protection or that they will
not  be  breached,  that  we would have adequate remedies for any such breach or
that  our  trade  secrets,  proprietary know-how and technological advances will
not  otherwise  become  known  to others. In addition, there can be no assurance
that,  despite  precautions  taken  by  us,  others have not and will not obtain
access  to  our proprietary technology or that such technology will not be found
to be non-proprietary or not a trade secret.


                                       13
<PAGE>

GOVERNMENTAL REGULATION

     Regulation  by  governmental  authorities  in  the  United States and other
countries   is  a  significant  factor  in  the  manufacture  and  marketing  of
pharmaceuticals  and  in our ongoing research and development activities. All of
our  therapeutic  products  will  require  regulatory  approval  by governmental
agencies  prior  to commercialization. In particular, human therapeutic products
are  subject  to  rigorous  preclinical  testing  and  clinical trials and other
pre-marketing  approval  requirements  by  the FDA and regulatory authorities in
other  countries. In the United States, various federal, and in some cases state
statutes  and  regulations also govern or impact upon the manufacturing, safety,
labeling,  storage,  record-keeping  and marketing of such products. The lengthy
process  of  seeking  required  approvals and the continuing need for compliance
with   applicable   statutes   and   regulations,  require  the  expenditure  of
substantial  resources.  Regulatory  approval,  when  and  if  obtained,  may be
limited  in  scope  which may significantly limit the indicated uses for which a
product   may   be   marketed.   Further,  approved  drugs,  as  well  as  their
manufacturers,  are  subject  to  ongoing  review  and  discovery  of previously
unknown  problems  with  such  products  may  result  in  restrictions  on their
manufacture,  sale or use or in their withdrawal from the market. Any failure by
us,  our  collaborators  or  licensees  to  obtain  or maintain, or any delay in
obtaining  regulatory  approvals  could  adversely  affect  the marketing of our
products,  and our ability to receive product revenue, royalty revenue or profit
sharing payments.


     The  activities  required  before  a  pharmaceutical may be marketed in the
United  States  begin  with  preclinical  testing  not involving human subjects.
Preclinical  tests include laboratory evaluation of product chemistry and animal
studies  to  assess  the  potential  safety  and  efficacy  of a product and its
formulations.  The results of these studies must be submitted to the FDA as part
of  an  Investigational  New Drug application, or IND, which must be reviewed by
the  FDA  primarily for safety considerations before proposed clinical trials in
humans can begin.

     Typically,  clinical  trials  involve  a  three-phase  process. In Phase I,
clinical  trials  are  generally conducted with a small number of individuals to
determine  the  early  safety  and  tolerability profile and the pattern of drug
distribution  and  metabolism  within  the  body.  If  the  Phase  I  trials are
satisfactory,  Phase II clinical trials are conducted with groups of patients in
order  to  determine  preliminary efficacy, dosing regimes and expanded evidence
of  safety.  In  Phase  III,  large-scale,  multi-center, adequately powered and
well-controlled,  comparative  clinical  trials  are  conducted with patients in
effort  to  provide enough data for the statistical proof of efficacy and safety
required  by  the  FDA  and others. However, in some limited circumstances Phase
III  trials may be modified to allow evaluation of safety and efficacy in a less
regimented  manner,  which  may  allow us to rely on historical data relating to
the  natural  course  of  disease  in  untreated  patients.  In some cases, as a
condition  of  NDA  approval,  confirmatory  trials are required to be conducted
after  the FDA's approval of an NDA in order to resolve any open issues. The FDA
requires  monitoring  of  all  aspects  of  clinical  trials  and reports of all
adverse  events must be made to the agency, both before and after drug approval.


     The  results  of  the preclinical testing and clinical trials are submitted
to  the  FDA  as  part  of  an NDA for evaluation to determine if the product is
adequate  for  approval  to  commence commercial sales. In responding to an NDA,
the  FDA  may  grant  marketing approval, request additional information or deny
the  application  if  it  determines  that  the application does not satisfy its
regulatory  approval  criteria.  When  an NDA is approved, the manufacturer must
employ  a  system  for obtaining reports of experience and side effects that are
associated with the drug and make appropriate submissions to the FDA.

     Pursuant  to  the  Orphan  Drug  Act,  a  sponsor  may request that the FDA
designate  a  drug intended to treat a "rare disease or condition" as an "orphan
drug."  A  "rare disease or condition" is defined as one which affects less than
200,000  people  in the United States or which affects more than 200,000 people,
but  for  which  the  cost  of  development and making available the drug is not
expected  to  be recovered from sales of the drug in the United States. Upon the
approval  of  the  first  NDA  for  a  drug  designated  as an orphan drug for a
specified  indication, the sponsor of the NDA is entitled to exclusive marketing
rights  in  the United States for such drug for that indication for seven years.
Orphan  drugs  may  also  be  eligible  for federal income tax credits for costs
associated  with  the  drug's development. Possible amendment of the Orphan Drug
Act by the United States Congress and possible reinterpretation by the


                                       14
<PAGE>

FDA  are  the subject of frequent discussion. FDA regulations reflecting certain
definitions,  limitations  and  procedures initially went into effect in January
1993  and  were  amended  in  certain  respects  in 1998. Therefore, there is no
assurance  as  to the precise scope of protection that may be afforded by orphan
drug  status  in  the  future  or  that the current level of exclusivity and tax
credits  will  remain  in  effect.  We  have  received  from the FDA orphan drug
approval  for  thalidomide  for  the treatment of ENL. Celgene also has received
orphan  drug  designations  for  thalidomide:  for  the  treatment  of  multiple
myeloma;   for  the  treatment  of  HIV-associated  wasting  syndrome;  for  the
treatment  of  the  clinical manifestations of mycobacterial infection caused by
Mycobacterium  tuberculosis and non-tuberculosis mycobacteria; for the treatment
of  severe  recurrent  apthous  stomatitis  in  severely, terminally compromised
patients;  and  for  the  treatment  of Crohn's disease. We also obtained orphan
drug  designation  in Kaposi's sarcoma and primary brain malignancies as part of
our  agreement  with  EntreMed.  However, there can be no assurance that another
company  also holding orphan drug designation will not receive approval prior to
us  for  the  use  of  thalidomide  for  the  treatment  of one or more of these
indications,  other  than ENL. If that were to happen, our applications for that
indication  could  not  be  approved  until  the  competing company's seven-year
period of exclusivity expired.

     Among  the  conditions  for  NDA  approval  is  the  requirement  that  the
prospective   manufacturer's   quality   control  and  manufacturing  procedures
continually  conform  with the FDA's cGMP. In complying with cGMP, manufacturers
must  devote  extensive  time,  money  and  effort in the area of production and
quality  control  and  quality  assurance to maintain full technical compliance.
Manufacturing   facilities   and   company   records  are  subject  to  periodic
inspections  by the FDA to ensure compliance. If a manufacturing facility is not
in  substantial  compliance  with  these  requirements,  regulatory  enforcement
action  may  be taken by the FDA which may include seeking an injunction against
shipment  of  products  from  the  facility  and  recall  of products previously
shipped from the facility.

     Failure  to  comply  with applicable FDA regulatory requirements can result
in  informal administrative enforcement actions such as warning letters, recalls
or  adverse  publicity  issued  by the FDA or in legal actions such as seizures,
injunctions,  fines  based  on the equitable remedy of disgorgement, restitution
and criminal prosecution.

     Steps  similar  to  those  in  the  United  States  must  be  undertaken in
virtually  every other country comprising the market for our products before any
such  product  can  be commercialized in those countries. The approval procedure
and  the time required for approval vary from country to country and may involve
additional  testing. There can be no assurance that approvals will be granted on
a  timely  basis  or  at  all.  In  addition,  regulatory  approval of prices is
required  in  most  countries  other  than  the  United  States. There can be no
assurance  that  the  resulting  prices  would  be  sufficient  to  generate  an
acceptable return to us.

COMPETITION

     The  pharmaceutical  and  agrochemical  industries  in which we compete are
each  highly  competitive.  Our  competitors  include  major  pharmaceutical and
biotechnology  companies,  most  of  which  have considerably greater financial,
technical  and  marketing  resources  than us. We also experience competition in
the  development  of  our  products  and  processes  from universities and other
research  institutions  and, in some instances, compete with others in acquiring
technology from such sources.

     Competition  in  the  pharmaceutical  industry,  and  specifically  in  the
oncology  and  immunology  areas being addressed by us, is particularly intense.
Numerous  companies are pursuing techniques to modulate TNF-- production through
various  combinations  of  monoclonal  antibodies,  TNF--  receptors  and  small
molecule   approaches.  Two  U.S.  companies,  Centocor  Inc.,  a  wholly  owned
subsidiary  of Johnson & Johnson, and Immunex Corporation, have registered drugs
that  block  the  disease-causing effects of TNF-- in inflammatory arthritis and
bowel  disease.  Both  drug  products are registered in the United States and in
Europe  and have been marketed since 1998. In the United States the present cost
of  TNF--  modulating  drugs, not including medical or other charges, is between
$7,000  and  $11,500 per patient year. Amgen Inc. is currently also developing a
soluble  TNF--  receptor.  BASF  A.G.  has  a  human antibody in development and
Celltech  Group  plc  has  a  humanized antibody. In addition, a number of other
companies  are  attempting to address, with other technologies and products, the
disease states currently


                                       15
<PAGE>

being  targeted  by  us.  EntreMed  is  researching the effectiveness of its own
thalidomide  analogues  as  anti-angiogenic  agents  in the treatment of retinal
disease  and  cancer.  Andrulis  Pharmaceuticals  Corp., a small, privately held
company,  is attempting to develop thalidomide for the treatment of AIDS-related
complications.

     Several   companies   have   established   chiral   products   and   chiral
technologies.  Sepracor  Inc. and Chiroscience Group plc are actively developing
chirally  pure  versions  of pharmaceuticals currently marketed in racemic form.
Chiroscience  has  completed Phase I trials in the United Kingdom for a chirally
pure  version  of  dl-methylphenidate  and is working with Medeva plc, a leading
supplier  of  dl-methylphenidate  in  the  United  States, towards full clinical
development.  Chiroscience  has  also  taken  certain steps to assert patent and
proprietary  rights  with  respect to its formulation of a chirally pure version
of  dl-methylphenidate.  The  agrochemical  market  is  large  and,  within this
market,  efforts are underway by the in-house development staffs of agrochemical
companies  to  produce  chirally  pure  versions  of their existing racemic crop
protection agents.

     The  pharmaceutical  and  agrochemical  industries  have undergone, and are
expected  to  continue  to  undergo, rapid and significant technological change,
and  competition  is  expected  to intensify as technical advances in each field
are  made and become more widely known. In order to compete effectively, we will
be  required  to  continually  upgrade  our scientific expertise and technology,
identify  and  retain capable management, and pursue scientifically feasible and
commercially viable opportunities.

     Our  competition  will  be  determined in part by the indications for which
our  products  are  developed and ultimately approved by regulatory authorities.
An  important factor in competition will be the timing of market introduction of
our  or our competitors' products. Accordingly, the relative speed with which we
can  develop  products,  complete  clinical  trials  and  approval processes and
supply  commercial  quantities  of products to the market will be expected to be
important  competitive  factors.  Competition  among  products approved for sale
will  be  based,  among  other things, on product efficacy, safety, convenience,
reliability, availability, price and patent position.

MANUFACTURING

     THALOMID  is  formulated  and  encapsulated  for us by Penn Pharmaceuticals
Ltd.  of  Great  Britain  in an FDA approved facility devoted exclusively to the
production  of  THALOMID  capsules.  Both  the  bulk manufacturing facility that
produces  the  drug  substance  for  THALOMID  and  the  Penn facility have been
certified  as  cGMP  compliant. In certain instances, we may be required to make
substantial  capital  expenditures  to access additional manufacturing capacity.
In  addition,  we  have  established a contract with another cGMP certified bulk
drug  substance  supplier  for  THALOMID  that  will  begin  in  2001  once  the
regulatory  process  is  completed.  We  are  also actively seeking an alternate
manufacturer   to   provide   additional   capacity   for  the  formulation  and
encapsulation of THALOMID and expect that this will be concluded in 2000.

SALES AND COMMERCIALIZATION

     We  have  established  an  organization of approximately 60 persons to sell
and  commercialize  THALOMID.  These individuals have considerable experience in
the  pharmaceutical  industry  and  many  have  experience  with oncological and
immunological   products.   We   expect   to   expand  our  THALOMID  sales  and
commercialization  group to support products we develop to treat oncological and
immunological  diseases.  We  intend  to market and sell the products we develop
for  indications with accessible patient populations. For drugs with indications
with   larger   patient   populations,   we  anticipate  partnering  with  other
pharmaceutical  companies.  In  addition,  we  are  positioned to accelerate the
expansion  of  these sales resources as appropriate to take advantage of product
in-licensing  and  product  acquisition  opportunities.  We  intend to establish
commercial  relationships  with  selected companies in other countries to market
THALOMID.

EMPLOYEES

     As  of  March  15,  2000,  we  had 151 full-time employees, 47 of whom were
engaged  primarily  in  research  and  development  activities,  60 of whom were
engaged in sales and commercialization activities


                                       16
<PAGE>

and  the  remainder  of  whom  were  engaged  in  executive  and  administrative
activities.  Of these employees, 55 have advanced degrees, including 26 who have
Ph.D.  degrees.  We  also  maintain  consulting  arrangements  with  a number of
scientists  at  various  universities  and other research institutions in Europe
and the United States.


FORWARD-LOOKING STATEMENTS

     Certain  statements  contained  or incorporated by reference in this annual
report   are  forward-looking  statements  concerning  our  business,  financial
condition,  results of operations, economic performance and financial condition.
Forward-looking  statements  within the meaning of Section 27A of the Securities
Act  of  1933  and  within the meaning of Section 21E of the Securities Exchange
Act of 1934 are included, for example, in the discussions about:

     - our strategy;

     - new product development or product introduction;

     - product sales, royalties and contract revenues;

     - expenses and net income;

     - our credit risk management;

     - our liquidity;

     - our asset/liability risk management; and

     - our operational and legal risks.

     These  statements  involve  risks  and  uncertainties.  Actual  results may
differ  materially  from those expressed or implied in those statements. Factors
that  could  cause  such  differences  include,  but  are  not limited to, those
discussed  under  "Risk  Factors"  and  "Management's Discussion and Analysis of
Financial Condition and Results of Operations."

RISK FACTORS

     IF  WE ARE UNSUCCESSFUL IN DEVELOPING AND COMMERCIALIZING OUR PRODUCTS, OUR
BUSINESS,  FINANCIAL  CONDITION  AND  RESULTS  OF OPERATIONS COULD BE MATERIALLY
ADVERSELY AFFECTED.

     Many  of  our  products  and  processes  are  in the early or mid-stages of
development  and will require the commitment of substantial resources, extensive
research,  development,  preclinical  testing,  clinical  trials,  manufacturing
scale-up  and regulatory approval prior to being ready for sale. We have not yet
sold  any  of  our  products other than THALOMID. All of our other products will
require  further  development,  clinical  testing  and regulatory approvals, and
there  can  be  no  assurance that commercially viable products will result from
these  efforts.  If  any of our products, even if developed and approved, cannot
be  successfully  commercialized,  our business, financial condition and results
of operations could be materially adversely affected.

     DURING  THE NEXT SEVERAL YEARS, WE WILL BE VERY DEPENDENT ON THE COMMERCIAL
SUCCESS OF THALOMID.

     At  our  present  level  of  operations,  we  may  not  be  able  to attain
profitability  if physicians prescribe THALOMID only for those who are diagnosed
with  ENL.  Under  current  FDA  regulations,  we  are limited in our ability to
promote  THALOMID  outside this approved use. The market for the use of THALOMID
in  patients  suffering from ENL is relatively small. We have initiated clinical
studies  to  examine  whether or not THALOMID is effective and safe when used to
treat  disorders  other  than ENL, but we do not know whether these studies will
in  fact demonstrate safety and efficacy, or if they do, whether we will succeed
in  receiving regulatory approval to market THALOMID for additional indications.
If  the  results  of  these  studies are negative, or if adverse experiences are
reported  in  these  clinical studies or otherwise in connection with the use of
THALOMID  by  patients,  this could undermine physician and patient comfort with
the product, could limit the commercial success of the product and


                                       17
<PAGE>

could  even impact the acceptance of THALOMID in the ENL market. FDA regulations
restrict  our  ability to communicate the results of additional clinical studies
to  patients  and  physicians  without  first obtaining approval from the FDA to
expand the authorized uses for this product.

     IF  OUR  PRODUCTS  ARE  NOT ACCEPTED BY THE MARKET, OUR BUSINESS, FINANCIAL
CONDITION AND RESULTS OF OPERATIONS COULD BE MATERIALLY ADVERSELY AFFECTED.

     There  can  be  no  assurance  that  those  of  our  products  that receive
regulatory  approval,  including  THALOMID,  or  those  products  for  which  no
regulatory  approval  is  required,  will achieve market acceptance. A number of
factors  render  the  degree  of  market  acceptance  of our products uncertain,
including  the extent to which we can demonstrate the products' efficacy, safety
and  advantages,  if  any, over competing products, as well as the reimbursement
policies  of third party payors, such as government and private insurance plans.
Failure  of  our  products  to  achieve  market acceptance would have a material
adverse effect on our business, financial condition and results of operations.

      WE  FACE  A RISK OF PRODUCT LIABILITY CLAIMS AND MAY NOT BE ABLE TO OBTAIN
INSURANCE.

     We   may  be  subject  to  product  liability  or  other  claims  based  on
allegations  that  the use of our technology or products has resulted in adverse
effects,  whether  by  participants  in our clinical trials or by patients using
our  products. Thalidomide, when used by pregnant women, has resulted in serious
birth  defects.  Therefore,  necessary  and  strict precautions must be taken by
physicians  prescribing the drug to women with childbearing potential, and there
can  be  no assurance that such precautions will be observed in all cases or, if
observed,  will  be effective. Use of thalidomide has also been associated, in a
limited  number  of  cases,  with  other  side  effects, including nerve damage.
Although  we  have  product  liability insurance that we believe is appropriate,
there  can be no assurance that we will be able to obtain additional coverage if
required,  or  that  such  coverage  will be adequate to protect us in the event
claims  are  asserted  against  us.  Our obligation to defend against or pay any
product  liability  or  other  claim  may  have a material adverse effect on our
business, financial condition and results of operations.

     WE  HAVE  A  HISTORY OF OPERATING LOSSES AND AN ACCUMULATED DEFICIT AND MAY
NEED TO SEEK ADDITIONAL FUNDING.

     We  have  sustained losses in each year since our incorporation in 1986. We
sustained  net  losses of $21.8 million, $25.1 million and $25.4 million for the
years  ended  December 31, 1999, 1998 and 1997. We had an accumulated deficit of
$166.4  million  and  $144.6 million at December 31, 1999 and 1998. We expect to
make   substantial   expenditures  to  further  develop  and  commercialize  our
products,  and,  based  on  these  expenditures, it is probable that losses will
continue  for  at least the next six months. We expect that our rate of spending
will  accelerate  as  the  result of increased clinical trial costs and expenses
associated  with  regulatory  approval  and commercialization of products now in
development.  In  order  to  fund  our  future  operations,  we will likely seek
additional  capital.  We  may  not  be  able  to  raise  additional  capital  on
reasonable   terms,   if  at  all.  There  can  be  no  assurance,  assuming  we
successfully  raise  additional  funds,  that  we  will achieve profitability or
positive cash flow.

     WE  MAY  EXPERIENCE  SIGNIFICANT  FLUCTUATIONS  IN  OUR QUARTERLY OPERATING
RESULTS.

     We   have   historically  experienced,  and  expect  to  continue  for  the
foreseeable  future  to  experience,  significant  fluctuations in our quarterly
operating  results.  These  fluctuations are due to a number of factors, many of
which  are outside our control, and may result in volatility of our stock price.
Future operating results will depend on many factors, including:

     - demand for our products;

     - regulatory approvals for our products;

     - the timing of the introduction  and market  acceptance of new products by
       us or competing companies;

     - the timing of certain research and development milestones; and

     - our ability to control our costs.

                                       18
<PAGE>

     WE  HAVE NO MANUFACTURING CAPABILITIES AND WE ARE DEPENDENT ON ONE SUPPLIER
FOR  THE RAW MATERIAL AND ONE MANUFACTURER FOR THE FORMULATION AND ENCAPSULATION
OF THALOMID.

     We   currently   have   no  experience  in,  or  our  own  facilities  for,
manufacturing  any  products  on a commercial scale. Currently, we obtain all of
our  bulk drug material for THALOMID from a single supplier and rely on a single
manufacturer  to  formulate  and encapsulate THALOMID. The FDA requires that all
suppliers   of   pharmaceutical   bulk   material   and   all  manufacturers  of
pharmaceuticals  for  sale  in  or  from  the United States achieve and maintain
compliance  with  the  FDA's  current  Good  Manufacturing  Practice,  or  cGMP,
regulations  and  guidelines. If the operations of the sole supplier or the sole
manufacturer  were to become unavailable for any reason, the required FDA review
and  approval  of  the  operations  of  a new supplier or new manufacturer could
cause  a  delay  in  the  manufacture  of  THALOMID  which could have a material
adverse  effect  on our business, financial condition and results of operations.
We  intend  to  continue  to utilize outside manufacturers if and when needed to
produce  our  other products on a commercial scale. If our outside manufacturers
do  not  meet  our  requirements  for quality, quantity or timeliness, or do not
achieve  and  maintain compliance with all applicable regulations, our business,
financial  condition  and  results  of  operations could be materially adversely
affected.

     WE HAVE LIMITED MARKETING AND DISTRIBUTION CAPABILITIES.

     Although  we  have  a  60  person sales and commercialization group to sell
THALOMID,  we  may  be required to seek a corporate partner to provide marketing
services  with  respect  to  our  other  products. Any delay in developing these
resources  could have a material adverse impact on our results of operations. We
have  contracted with a specialty distributor to distribute THALOMID. Failure of
this  specialty  distributor  to  perform  its obligations could have a material
adverse effect on our business, financial condition and results of operations.

     WE ARE DEPENDENT ON COLLABORATIONS AND LICENSES WITH THIRD PARTIES.

     Our  ability  to fully commercialize our products, if developed, may depend
to  some extent upon our entering into joint ventures or other arrangements with
established   pharmaceutical   companies   with  the  requisite  experience  and
financial  and other resources to obtain regulatory approvals and to manufacture
and  market  such  products.  Accordingly, our success may depend, in part, upon
the  subsequent  success  of  such  third  parties in performing preclinical and
clinical  trials,  obtaining  the  requisite  regulatory  approvals,  scaling up
manufacturing,  successfully commercializing the licensed product candidates and
otherwise performing their obligations to us. We cannot assure you that:

     - we will be able to enter into joint  ventures  or other  arrangements  on
       acceptable terms, if at all;

     - our joint ventures or other arrangements will be successful;

     - our joint  ventures  or other  arrangements  will lead to the  successful
       development and commercialization of any products;

     - we will be able to obtain or maintain  proprietary  rights or licenses to
       any  technology  or  products  developed  in  connection  with our  joint
       ventures or other arrangements; or

     - we will be able to preserve the confidentiality of any proprietary rights
       or information  developed in connection  with our joint ventures or other
       arrangements.

     THE  HAZARDOUS  MATERIALS  WE  USE  IN  OUR  RESEARCH AND DEVELOPMENT COULD
RESULT  IN SIGNIFICANT LIABILITIES WHICH COULD EXCEED OUR INSURANCE COVERAGE AND
FINANCIAL RESOURCES.

     We   use   some   hazardous  materials  in  our  research  and  development
activities.  While  we  believe  we are currently in substantial compliance with
the  federal,  state  and  local laws and regulations governing the use of these
materials,  we  cannot  assure  you that accidental injury or contamination will
not  occur.  Any  such  accident  or  contamination  could result in substantial
liabilities,  which could exceed our insurance coverage and financial resources.
Additionally,   we   cannot   assure  you  that  the  cost  of  compliance  with
environmental and safety laws and regulations will not increase in the future.


                                       19
<PAGE>

     RESIDUAL  YEAR  2000  PROBLEMS  COULD  CAUSE  A  MATERIAL DISRUPTION IN OUR
BUSINESS.

     Although  all  of  our computer hardware and software has been upgraded for
Year  2000  compliance, all of our key vendors have provided assurance that they
are  Year  2000  compliant  and there were no related problems at the transition
into  the  Year 2000, any residual effect of the Year 2000 problem could cause a
material disruption in our business.

INDUSTRY RISKS

     THE  PHARMACEUTICAL  AND  AGROCHEMICAL  INDUSTRIES ARE SUBJECT TO EXTENSIVE
GOVERNMENT REGULATION AND THERE IS NO ASSURANCE OF REGULATORY APPROVAL.

     The  preclinical development, clinical trials, manufacturing, marketing and
labeling  of pharmaceuticals are all subject to extensive regulation by numerous
governmental  authorities and agencies in the United States and other countries.
There  can  be  no  assurance  that  we  will  be  able  to obtain the necessary
approvals  required to market our products in any of these markets. The testing,
marketing  and  manufacturing  of our products will require regulatory approval,
including  approval from the FDA and, in some cases, from the U.S. Environmental
Protection  Agency,  or  the EPA, and the U.S. Department of Agriculture, or the
USDA,  or  governmental  authorities  outside  of the United States that perform
roles  similar  to  those  of  the  FDA  and  EPA. Certain of our pharmaceutical
products  in  development also fall under the Controlled Substances Act of 1970,
or  the  CSA,  which requires authorization by the U.S. Drug Enforcement Agency,
or  the DEA, of the U.S. Department of Justice in order to handle and distribute
these  products.  It  is not possible to predict how long the approval processes
of  the  FDA,  EPA,  DEA  or  any  other  applicable  federal,  state or foreign
regulatory  authority or agency for any of our products will take or whether any
such  approvals  ultimately  will  be  granted.  Positive results in preclinical
testing  and/or  early phases of clinical studies are no assurance of success in
later  phases  of  the  approval  process.  Risks associated with the regulatory
approval process include:

   - in  general,  preclinical  tests  and  clinical trials can take many years,
     and  require  the  expenditure  of  substantial  resources,  and  the  data
     obtained  from  these  tests  and  trials  can  be  susceptible  to varying
     interpretation that could delay, limit or prevent regulatory approval;

   - delays   or   rejections  may  be  encountered  during  any  stage  of  the
     regulatory  approval  process  based  upon  the  failure of the clinical or
     other  data  to  demonstrate  compliance  with,  or upon the failure of the
     product  to  meet,  a regulatory agency's requirements for safety, efficacy
     and  quality  or,  in  the  case  of  a  product  seeking  an  orphan  drug
     indication, because another designee received approval first;

   - requirements  for  approval  may  become  more  stringent due to changes in
     regulatory   agency   policy,   or  the  adoption  of  new  regulations  or
     legislation;

   - the  scope  of  any  regulatory  approval, when obtained, may significantly
     limit the indicated uses for which a product may be marketed;

   - approved  drugs  and  agrochemicals,  as  well  as their manufacturers, are
     subject  to  continuing  and  on-going  review, and discovery of previously
     unknown  problems  with  these products may result in restrictions on their
     manufacture, sale or use or in their withdrawal from the market; and

   - regulatory  authorities  and agencies may promulgate additional regulations
     restricting the sale of our existing and proposed products.

     Once  approved,  we  cannot guarantee that the FDA will permit us to market
those  products  for broader or different applications, or that it will grant us
approval   with   respect  to  separate  product  applications  which  represent
extensions  of  our  basic  technology,  or  that existing approvals will not be
withdrawn  or modified in a significant manner. In addition, it is possible that
the  FDA  will  promulgate  additional  regulations  restricting the sale of our
present or proposed products.

     Labeling  and promotional activities are subject to scrutiny by the FDA and
state  regulatory  agencies  and,  in  some  circumstances, by the Federal Trade
Commission.  FDA enforcement policy prohibits the marketing of approved products
for unapproved, or off-label, uses. These regulations, and the FDA's


                                       20
<PAGE>

interpretation  of  them,  may impair our ability to effectively market THALOMID
or  other  products  which  gain approval. The FDA actively enforces regulations
prohibiting  promotion of off-label uses and the promotion of products for which
approval  has  not  been obtained. Failure to comply with these requirements can
result  in  regulatory  enforcement  action  by  the  FDA. The FDA is aware that
physicians  prescribe  THALOMID for off-label uses and has not, as of this date,
initiated  any  regulatory actions against us. FDA approval of THALOMID requires
that  we  distribute  it  under the rigid standards of our S.T.E.P.S. program in
order to maintain approval.

     Delays  in  obtaining,  or  the  failure  to obtain and maintain, necessary
approvals  from  the FDA, EPA, DEA or other applicable regulatory authorities or
agencies  for  our proprietary products or regulatory enforcement actions by FDA
concerning  our  marketing practices would have a material adverse effect on our
business, financial condition and results of operations.

     WE MAY NOT BE ABLE TO PROTECT OUR INTELLECTUAL PROPERTY.

     Our  success  will  depend,  in  part, on our ability to obtain and enforce
patents,  protect  trade  secrets,  obtain licenses to technology owned by third
parties,  when  necessary,  and conduct our business without infringing upon the
proprietary  rights  of  others.  The  patent positions of pharmaceutical firms,
including  ours,  can  be  uncertain  and  involve  complex  legal  and  factual
questions.  In  addition, the coverage sought in a patent application may not be
obtained   or  may  be  significantly  reduced  before  the  patent  is  issued.
Consequently,  we  do  not  know  whether  any  of our pending applications will
result  in  the  issuance of patents or, if any patents are issued, whether they
will  provide significant proprietary protection or commercial advantage. If any
of  our  issued  or  licensed patents are infringed, we cannot guarantee that we
will  be  successful in enforcing our intellectual property rights. Moreover, we
cannot   assure   you  that  we  can  successfully  defend  against  any  patent
infringement  suit  that  may  be  brought  against  us by a third party. Patent
infringement  lawsuits in the pharmaceutical and biotechnology industries can be
complex,  lengthy  and  costly to both parties. Further, we rely upon unpatented
proprietary  and  trade  secret  technology  that we try to protect, in part, by
confidentiality   agreements   with   our   collaborative  partners,  employees,
consultants,  outside  scientific collaborators, sponsored researchers and other
advisors.  There  can be no assurance that these agreements will not be breached
or  that  we  would have adequate remedies for any such breach. We cannot assure
you  that,  despite precautions taken by us, others have not and will not obtain
access  to  our proprietary technology or that such technology will not be found
to  be  non-proprietary  or  not  a  trade  secret.  Our  right  to practice the
inventions  claimed  in  some patents which relate to products under development
and  THALOMID arises under licenses granted to us by others, including EntreMed,
Inc.  and  The  Rockefeller  University. While we believe these agreements to be
valid  and  enforceable,  we  cannot  assure  you  that  our  rights under these
agreements  will  continue  or that disputes concerning these agreement will not
arise.  In  addition, certain of the grants contained in the licenses granted to
us  depend  upon the validity and enforceability of other agreements to which we
are not a party.

     THE  PHARMACEUTICAL  AND AGROCHEMICAL INDUSTRIES ARE HIGHLY COMPETITIVE AND
SUBJECT TO RAPID AND SIGNIFICANT TECHNOLOGICAL CHANGE.

     The  pharmaceutical  and  agrochemical  industries  in which we operate are
highly  competitive  and  subject to rapid and significant technological change.
Our  present and potential competitors include major chemical and pharmaceutical
companies,  as well as specialized pharmaceutical firms. Most of these companies
have  considerably greater financial, technical and marketing resources than us.
We   also   experience   competition   from   universities  and  other  research
institutions  and,  in  some  instances,  we  compete  with  others in acquiring
technology  from  these  sources. The pharmaceutical and agrochemical industries
have  undergone,  and are expected to continue to undergo, rapid and significant
technological  change,  and  we  expect  competition  to  intensify as technical
advances  in  each  field are made and become more widely known. The development
of  products  or  processes  with  significant advantages over those that we are
seeking  to  develop  could  have  a  material  adverse  effect on our business,
financial condition and results of operations.


                                       21
<PAGE>

     SALES OF OUR PRODUCTS ARE DEPENDENT ON THIRD-PARTY REIMBURSEMENT.

     Sales  of  our  products  will  depend, in part, on the extent to which the
costs  of  our  products  will  be  paid  by  health  maintenance, managed care,
pharmacy   benefit   and   similar  health  care  management  organizations,  or
reimbursed  by  government  health  administration  authorities,  private health
coverage  insurers  and  other  third-party payors. These health care management
organizations  and  third-party  payors  are increasingly challenging the prices
charged  for  medical  products  and  services. Additionally, the containment of
health  care  costs  has become a priority of federal and state governments, and
the  prices  of  drugs  have  been targeted in this effort. We cannot assure you
that   our   products   will  be  considered  cost  effective  by  payors,  that
reimbursement   will   be   available  or,  if  available,  that  the  level  of
reimbursement  will  be  sufficient  to  allow  us  to  sell  our  products on a
profitable basis.

ITEM 2. PROPERTIES

     We  lease  a  44,500-square  foot laboratory and office facility in Warren,
New  Jersey,  under  a lease with an unaffiliated party, which has a term ending
in  May  2002  with  one  five-year  renewal  option,  and  a 29,000-square foot
facility  which  has  a  term  ending  in  July  2010 with two five-year renewal
options.  We  also lease an 18,000-square foot laboratory and office facility in
North  Brunswick, New Jersey, under a lease with an unaffiliated party which has
a  term  ending  in December 2009 with two five-year renewal options. We believe
that  our  laboratory  facilities  are adequate for our research and development
activities for at least the next 12 months.

ITEM 3. LEGAL PROCEEDINGS

     We are not engaged in any material legal proceedings.

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

     None

                                       22
<PAGE>

                                    PART II

ITEM 5. MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER MATTERS

     Our  common  stock is traded on the Nasdaq National Market under the symbol
"CELG."  The  following  table  sets  forth,  for  the  periods  indicated,  the
intra-day  high  and  low  sale  prices  per share of common stock on the Nasdaq
National Market:

<TABLE>
<CAPTION>
                                      HIGH          LOW
                                   ----------   ----------
<S>                                <C>          <C>
1999 ...........................
  Fourth Quarter ...............   $72 5/8       $24 3/4
  Third Quarter ................    29            14
  Second Quarter ...............    20 1/16       13 9/16
  First Quarter ................    18 5/8        11 5/16
1998....... ....................
  Fourth Quarter ...............   $17 1/4       $ 7 1/2
  Third Quarter ................    15             4 1/8
  Second Quarter ...............    11 1/2         8 1/4
  First Quarter ................    11 5/8         6 15/16

</TABLE>

     The  last  reported  sales  price  per  share of common stock on the Nasdaq
National  Market  on  March 21, 2000 was $117 13/16. As of March 21, 2000, there
were approximately 450 holders of record of our common stock.

                                DIVIDEND POLICY

     We  have  never declared or paid any cash dividends on our common stock. We
currently  intend  to  retain  any  future  earnings  for  funding  growth  and,
therefore,  do  not  anticipate paying any cash dividends on our common stock in
the foreseeable future.

                                       23
<PAGE>

ITEM 6. SELECTED CONSOLIDATED FINANCIAL DATA

     The  following  Selected  Consolidated  Financial  Data  should  be read in
conjunction  with  the  our  Consolidated  Financial  Statements and the related
Notes  thereto, "Management's Discussion and Analysis of Financial Condition and
Results  of  Operations"  and  other financial information included elsewhere in
this  Annual  Report.  The data set forth below with respect to our Consolidated
Statements  of  Operations  for the years ended December 31, 1997, 1998 and 1999
and  the  balance  sheet  data as of December 31, 1998 and 1999 are derived from
our  Consolidated  Financial  Statements  which  have  been audited by KPMG LLP,
independent  certified  public  accountants, and which are included elsewhere in
this  Annual  Report  and  are  qualified  by  reference  to  such  Consolidated
Financial  Statements  and  related  Notes  thereto.  Some  information has been
derived  from  other  audited  consolidated financial statements. Our historical
results are not necessarily indicative of future results of operations.

<TABLE>
<CAPTION>
                                                                          YEAR ENDED DECEMBER 31,
                                           -------------------------------------------------------------------------------------
                                                  1995             1996             1997             1998             1999
                                           ----------------- ---------------- ---------------- ---------------- ----------------
<S>                                        <C>               <C>              <C>              <C>              <C>
Statements of Operations Data:
 Total revenues ..........................   $     472,000    $     881,665    $   1,122,193    $   3,800,490    $  26,209,624
 Loss from continuing operations .........      (8,366,380)     (17,057,521)     (25,019,844)     (32,022,873)     (21,781,200)
Discontinued operations:
 Loss from operations ....................      (2,150,143)        (761,461)        (427,183)         (59,837)              --
 Gain on sale of chiral assets ...........              --               --               --        7,014,830               --
 Net loss applicable to common
   stockholders ..........................   $ (10,516,523)   $ (21,609,640)   $ (26,921,501)   $ (25,092,528)   $ (21,781,200)
                                             =============    =============    =============    =============    =============
Per share of common stock-- basic
 and diluted:
 Loss from continuing operations .........   $       (1.04)   $       (1.81)   $       (2.05)   $       (1.98)   $       (1.20)
Discontinued operations:
 Loss from operations ....................           (0.27)           (0.08)           (0.03)              --               --
 Gain on sale of chiral assets ...........              --               --               --             0.43               --
 Net loss applicable to common
   stockholders ..........................           (1.30)   $       (2.29)   $       (2.20)   $       (1.55)   $       (1.28)
                                             =============    =============    =============    =============    =============
 Weighted average number of shares
   outstanding ...........................       8,073,000        9,450,000       12,215,000       16,160,000       17,012,000

</TABLE>


<TABLE>
<CAPTION>
                                                                               DECEMBER 31,
                                          ---------------------------------------------------------------------------------------
                                                1995             1996              1997              1998              1999
                                          ---------------- ---------------- ----------------- ----------------- -----------------
<S>                                       <C>              <C>              <C>               <C>               <C>
Balance Sheet Data:
 Cash and cash equivalents, and
   marketable securities ................  $  11,712,905    $  17,814,984    $   13,583,445    $    5,123,843    $   19,526,643
 Assets held for disposal ...............             --               --           485,170                --                --
 Total assets ...........................     14,211,218       20,937,862        18,217,456        11,927,997        32,333,670
 Convertible debentures .................      4,592,366        2,026,043                --                --                --
 Convertible notes ......................             --               --                --         8,348,959        38,494,795
 Accumulated deficit ....................    (70,989,400)     (92,599,039)     (119,520,540)     (144,613,068)     (166,394,268)
 Stockholders' equity (deficit) .........      7,142,501       16,065,009        15,425,092        (3,732,624)      (15,709,386)

</TABLE>

                                       24
<PAGE>

ITEM  7. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
        OF OPERATIONS

OVERVIEW

     We  were  organized  in  1980 as a unit of Celanese Corporation, a chemical
company.  Our  initial  mandate  was to apply biotechnology to the production of
fine  and specialty chemicals. Following the 1986 merger of Celanese Corporation
with  American  Hoechst Corporation, we were spun off as an independent company.
In  July  1987,  we completed an initial public offering of our common stock and
commenced  the  development  of  chemical  and  biotreatment  processes  for the
chemical   and  pharmaceutical  industries.  We  discontinued  the  biotreatment
operations  in  1994  to  focus  on  our  targeted  small  molecule  cancer  and
immunology  compound  development programs and our biocatalytic chiral chemistry
program.

     Since  1990,  our  revenues  have been generated primarily through research
and  development  relating  to,  and  supply  of, chirally pure intermediates to
pharmaceutical  companies  for  use  in  new  drug  development and, to a lesser
degree,  from  agrochemical  research  and development contracts. However, as we
developed   our   cancer   and  immunology  programs,  sales  of  chirally  pure
intermediates  became  a less integral part of our strategic focus. Accordingly,
on  January  9,  1998, we completed the sale of our chiral intermediate business
to  Cambrex  Corporation for $15.0 million. The terms of the sale provided for a
payment  of $7.5 million at closing and an additional amount of future royalties
not  to  exceed  the  net present value on the date of contract of $7.5 million,
with  a  guarantee of certain minimum payments beginning in the third year after
closing.

     In  late  September  1998,  we  commenced  sales  of  our  first commercial
product, THALOMID.

     We  have  sustained  losses  in  each  year since our inception in 1986. In
1999,  we  had  a  net  loss  of  $21.8 million and at December 31, 1999, had an
accumulated   deficit   of   $166.4  million.  We  expect  to  make  substantial
expenditures   to  further  commercialize  and  develop  THALOMID,  develop  our
oncology  and immunology programs and expand our chiral business. Based on these
expenditures,  it  is likely that losses will continue for at least the next six
months.

     Subject  to  the  risks  described  elsewhere in this Annual Report on Form
10-K,  we  believe  that  there  are  significant  market  opportunities for the
products  and  processes under development by us. To address these opportunities
in  a  timely  and  effective  manner,  we intend to seek out collaborations and
licensing  arrangements  with  third  parties.  We  have entered into agreements
covering  the  manufacture and distribution for us of certain compounds, such as
THALOMID,  and  the  development  by us of processes for producing chirally pure
crop   protection   agents  for  license  to  agrochemical  manufacturers.  This
development   is   performed   through  Celgro  Corporation,  our  wholly  owned
subsidiary.

     We  have  established  a  commercial  organization  to sell THALOMID and we
currently  employ  60  persons in this capacity. We intend to develop and market
our  own  pharmaceuticals  for  indications with accessible patient populations.
For  drugs  with  indications  for  larger  patient  populations,  we anticipate
partnering  with  other  pharmaceutical companies. We also anticipate partnering
with  companies  for  the development and commercialization of our chirally pure
pharmaceutical  and  agrochemical  products.  We  expect that these arrangements
typically  will  include  milestone  payments,  reimbursement  of  research  and
development expenses and royalty arrangements.

     Future  operating results will depend on many factors, including demand for
our   products,  regulatory  approvals  of  our  products,  the  timing  of  the
introduction   and  market  acceptance  of  new  products  by  us  or  competing
companies,  the timing of research and development milestones and our ability to
control costs.

RESULTS OF OPERATIONS
Fiscal Years Ended December 31, 1999, 1998 and 1997

     Total   revenues.   Total  revenues  in  1999  increased  significantly  to
approximately  $26.2  million  from  $3.8 million in 1998. The increase resulted
from  our  first full year of product sales of THALOMID in 1999 of approximately
$24.1  million  compared  with  $3.3 million of THALOMID sales in 1998. The 1998
sales


                                       25
<PAGE>

of  THALOMID  reflected  only  a partial year of sales, starting from the launch
date  at the end of the third quarter. Revenue from research contracts increased
to  $2.2  million in 1999 from $535,000 in 1998 and included a milestone payment
of  $500,000  related  to  ATTENADE.  The  1998  revenues  increased  by 238% to
approximately  $3.8  million  from  approximately $1.1 million in 1997. This was
due  to  product  sales  of  approximately  $3.3  million  of THALOMID which was
approved   in  1998  by  the  FDA  and  a  decrease  in  research  contracts  of
approximately  $.6  million  due  to completion of a contract at the end of 1997
with a major agrochemical company.

     Cost  of  goods  sold.  Cost  of  goods sold in 1999 was approximately $3.0
million  compared with approximately $282,000 in 1998. The cost of goods sold in
both  years does not reflect raw material or formulation and encapsulation costs
of  Thalomid,  as  these costs were charged as research and development expenses
prior to receiving FDA approval. There was no cost of goods sold in 1997.

     Research  and  development  expenses. Research and development expenses for
1999   were   slightly  lower  at  approximately  $19.6  million  compared  with
approximately  $19.8  million  in  1998. Increased spending for clinical trials,
primarily  for ATTENADE, was offset by a decrease in regulatory consulting fees,
university  research  program spending, and spending for THALOMID capsules which
was  charged as research and development expense prior to receiving FDA approval
in  July of 1998. Research and development expenses for 1998 increased by 14% to
approximately  $19.8  million  from  approximately  $17.4  million in 1997. This
increase  was primarily due to an increase of approximately $1.5 million for the
our  chiral pharmaceutical program primarily for clinical trials and preclinical
toxicology   studies   and   approximately   $780,000   relating   to   the  our
immunotherapeutic  program,  primarily for clinical trials for potential new NDA
filings for THALOMID.

     Selling,   general   and  administrative  expenses.  Selling,  general  and
administrative  expenses for 1999 increased by 62% over 1998, from approximately
$16.2  million  to  approximately  $26.2  million. The increase was primarily in
sales  and  marketing  expenses,  approximately  $3.6  million,  warehousing and
distribution  expenses, approximately $3.4 million, and expenditures relating to
medical  affairs  and  drug safety costs, approximately $730,000, all to support
the commercialization and distribution of THALOMID.

     Selling,  general  and administrative expenses for 1998 increased by 77% to
approximately  $16.2  million  from approximately $9.1 million in 1997. This was
primarily  due to sales and marketing expenses, $4.8 million, in anticipation of
the  THALOMID  product  launch  as well as post launch selling activities. Other
increases  were primarily related to the necessary infrastructure costs required
to  support  the commercial operations including medical affairs and drug safety
costs  of  $928,000, information systems development cost and additional finance
personnel,   $423,000,   and   other  administrative  expenses  such  as  legal,
consulting and investor relations of approximately $900,000.

     Interest  income and interest expense. Interest income for 1999 of $694,000
was  slightly  down  from  $705,000  in  1998  as  average  cash  balances  were
approximately  the same in both years. Interest income for 1998 increased by 42%
to  approximately $705,000 from approximately $496,000 in 1997. The increase was
due to higher average cash balances in 1998.

     Interest   expense   in   1999  was  significantly  higher  than  1998,  at
approximately  $2.8  million  compared  with approximately $256,000 in 1998. The
higher  interest  expense  resulted  from  the interest on the three convertible
notes  which were issued in September 1998, January 1999 and July 1999. Interest
expense  for  1998  increased  129%  to approximately $256,000 from $112,000 due
primarily  to  the  interest expenses associated with the 9.5% convertible notes
issued in September 1998.

     Loss  from  continuing  operations.  The  loss  from  continuing operations
decreased  32%  in  1999 compared with 1998, to approximately $21.8 million from
approximately  $32.0  million. The decreased loss resulted from the higher gross
profit  on  THALOMID  sales  and  an income tax benefit of $3.0 million from the
sale  of  a  portion  of  our New Jersey state net operating loss carryforwards,
offset  by  increased  selling,  general  and  administrative  costs  and higher
interest   expense.  The  loss  from  continuing  operations  increased  28%  to
approximately  $32.0  million  in 1998 from approximately $25.0 million in 1997.
The  increase  was  due  primarily to spending related to the launch of THALOMID
and  ongoing  research programs in chiral pharmaceuticals and immunotherapeutics
as described above.


                                       26
<PAGE>

     Loss  from  discontinued  operations. The loss from discontinued operations
decreased  to  $60,000  in  1998  from $427,000 in 1997 due to the fact that the
chiral  intermediate  business  was  sold  in  early  January  1998. The Company
recorded  a  gain on the sale of the chiral intermediate assets of approximately
$7.0 million in 1998.


LIQUIDITY AND CAPITAL RESOURCES

     Since  our  inception  in  1986,  we  have  financed  our  working  capital
requirements  primarily  through private and public sales of our debt and equity
securities,  income  earned  on  the investment of the proceeds from the sale of
such  securities,  and revenues from research contracts and product sales. As of
December  31,  1999, we have raised approximately $100.0 million in net proceeds
from  three  public  and  three  private offerings, including our initial public
offering  in  July  1987.  We  also  issued convertible notes in September 1998,
January  1999,  and  July 1999 with net proceeds aggregating approximately $38.0
million.

     Our  net  working  capital  at December 31, 1999 increased significantly to
approximately   $18.5   million  (primarily  cash  and  cash  equivalents)  from
approximately  $2.5  million  at  December  31,  1998.  The  increase in working
capital  was  primarily  due  to  the  cash  received  from  the issuance of the
convertible  notes  in  1999  and  1998  as well as collection of receivables on
sales of THALOMID.

     Cash  and  cash  equivalents  increased  by  $12.2  million  in  1999 while
marketable  securities  increased  by  $2.2 million from 1998. This reflects the
receipt  of  funds  from the issuance of the convertible notes and collection of
receivables from sales of THALOMID.

     We  expect  that  our  rate  of  spending  will  increase  as the result of
increased   clinical   trial  costs,  increased  expenses  associated  with  the
regulatory  approval  process  and  commercialization  of  products currently in
development,  increased  costs  related to the commercialization of THALOMID and
increased  working  capital  requirements.  On February 16, 2000, we completed a
public  offering  of  3,450,000  shares  of  our common stock. Proceeds from the
transaction  net  of  expenses,  were  approximately $278.0 million. These funds
plus  the  increasing revenues from sales of THALOMID should fund our operations
for the foreseeable future.

RECENTLY ISSUED ACCOUNTING STANDARDS

     In  December  1999,  the  staff  of  the Securities and Exchange Commission
issued  Staff  Accounting  Bulletin  ("SAB")  No.  101,  Revenue  Recognition in
Financial  Statements  ("SAB  101").  SAB  101 summarizes certain of the staff's
views   in   applying   generally  accepted  accounting  principles  to  revenue
recognition   in   financial   statements,   including   the   recognition   of
non-refundable  fees  received  upon  entering  into arrangements. We are in the
process  of  evaluating  this  SAB  and  the  effect  it will have on our future
consolidated financial statements and future revenue recognition policy.

YEAR 2000 COMPUTER SYSTEMS COMPLIANCE

     All  of  our computer hardware and software has been upgraded for Year 2000
compliance.  All  of  our key vendors have provided assurance that they are Year
2000  compliant.  While  there  were  no  Year  2000  related  problems  at  the
transition  into  the Year 2000, we are maintaining our contingency plans in the
event any problems arise in the future.

     The  statement  contained  in the foregoing Year 2000 readiness disclosures
is  subject  to  protection  under  the  Year  2000  Information  and  Readiness
Disclosure Act.

ITEM 7A. QUANTITIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

     Market Risk

     We  do not use derivative financial instruments. Our convertible notes have
a fixed interest rate.


ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

     See Part IV, Item 14 of this Annual Report.

                                       27
<PAGE>

ITEM  9. CHANGES  IN  AND  DISAGREEMENTS  WITH  ACCOUNTANTS  ON  ACCOUNTING  AND
         FINANCIAL DISCLOSURE

     Not applicable.

                                       28
<PAGE>

                                   PART III

ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

<TABLE>
<CAPTION>
                  NAME                     AGE                         POSITION
- ---------------------------------------   -----   --------------------------------------------------
<S>                                       <C>     <C>
John W. Jackson* ......................    55     Chairman of the Board and Chief Executive
                                                   Officer
Sol J. Barer, Ph.D.* ..................    52     President, Chief Operating Officer, Director
Robert J. Hugin* ......................    45     Chief Financial Officer and Senior Vice President
Jack L. Bowman ........................    67     Director
Frank T. Cary .........................    79     Director
Arthur Hull Hayes, Jr., M.D. ..........    66     Director
Gilla Kaplan, Ph.D. ...................    52     Director
Richard C. E. Morgan ..................    55     Director
Walter L. Robb, Ph.D. .................    71     Director
Lee J. Schroeder ......................    71     Director
</TABLE>

- ----------
* Executive Officer

     JOHN  W.  JACKSON  has  been  our Chairman of the Board and Chief Executive
Officer  since January 1996. From February 1991 to January 1996, Mr. Jackson was
President  of  Gemini  Medical,  a  consulting  firm  that  he founded and which
specialized  in  services  and  investment advice to start-up medical device and
biotechnology  companies.  Previously,  Mr.  Jackson  had  been President of the
worldwide  Medical  Device Division of American Cyanamid, a major pharmaceutical
company,  from February 1986 to January 1991 and served in various international
positions,  including Vice President -- International for American Cyanamid from
1978  to 1986. Mr. Jackson served in several human health marketing positions at
Merck  & Company, a major pharmaceutical company, from 1971 to 1978. Mr. Jackson
received a B.A. degree from Yale University and an M.B.A. from INSEAD, France.

     SOL  J.  BARER,  PH.D.  has  been  our President since October 1993 and our
Chief  Operating  Officer  and  one of our directors since March 1994. Dr. Barer
was   our   Senior   Vice   President   --   Science  and  Technology  and  Vice
President/General  Manager  -- Chiral Products from October 1990 to October 1993
and  our  Vice  President -- Technology from September 1987 to October 1990. Dr.
Barer   received  a  Ph.D.  in  organic  and  physical  chemistry  from  Rutgers
University.

     ROBERT  J.  HUGIN  has  been  our Senior Vice President and Chief Financial
Officer  since  June 1999. Previously, Mr. Hugin had been a Managing Director at
J.P.  Morgan  &  Co.  Inc.,  which he joined in 1985. Mr. Hugin received an A.B.
degree  from Princeton University and an M.B.A. from the University of Virginia.

     JACK  L.  BOWMAN,  one of our directors since April 1998, served as Company
Group  Chairman  of  Johnson & Johnson from 1987 to 1994. From 1983 to 1987, Mr.
Bowman  served  as  Executive Vice President of American Cyanamid. Mr. Bowman is
also   a   director   of  NeoRx  Corporation,  Cell  Therapeutics,  Inc.,  CytRx
Corporation, Cellegy Pharmaceuticals and Targeted Genetics.

     FRANK  T. CARY has been Chairman of the Executive Committee of our board of
directors  since  July  1990  and has been one of our directors since 1987. From
1973  to 1981, Mr. Cary was Chairman of the Board and Chief Executive Officer of
International  Business  Machines  Corporation.  Mr.  Cary also is a director of
Cygnus  Therapeutic  Systems  Inc.,  ICOS  Corporation,  Lincare  Inc.,  Lexmark
International Inc., Vion Pharmaceuticals Inc. and Teltrend, Inc.

     ARTHUR  HULL  HAYES,  JR.,  M.D., one of our directors since 1995, has been
President  and  Chief  Operating Officer of MediScience Associates, a consulting
organization  that  works  with  pharmaceutical  firms, biomedical companies and
foreign  governments,  since  July  1991.  Dr.  Hayes has also been a partner in
Issue  Sphere,  a  public  affairs  firm  that focuses on health science issues,
since  November  1995,  as  well  as  a  professor in medicine, pharmacology and
family and community medicine at New York Medical


                                       29
<PAGE>

College  and clinical professor of medicine and pharmacology at the Pennsylvania
State  University  College  of  Medicine.  From  1986  to  1990,  Dr.  Hayes was
President  and  Chief  Executive  Officer  of E.M. Pharmaceuticals, a unit of E.
Merck  AG  and  from 1981 to 1983 was Commissioner of the United States Food and
Drug  Administration.  Dr.  Hayes  also  is a director of Myriad Genetics, Inc.,
NaPro BioTherapeutics, Inc. and Premier Research Worldwide.

     GILLA  KAPLAN,  PH.D.,  one  of  our  directors  since  April  1998,  is an
immunologist  in  the  Laboratory  of  Cellular Physiology and Immunology at The
Rockefeller  University  in New York where she was appointed Assistant Professor
in  1985  and  Associate  Professor  in 1990. Dr. Kaplan is a member of numerous
professional  societies  and has been the organizer of several major symposia on
tuberculosis.  Dr.  Kaplan  has  served  as an advisor to the Global Program for
Vaccines  and Immunization of the World Health Organization, has participated in
several  NIH peer review panels, and is on the Editorial Board of Microbial Drug
Resistances,  and  Tubercle  and  Lung Disease. Dr. Kaplan is the author of more
than  100 scientific publications and has received international recognition for
her  work.  In  1995,  she  gave  the  Special  Honorary Lecture at the American
Society  for  Microbiology  and  in  1997 was appointed a Fellow of the American
Academy of Microbiology.

     RICHARD  C.  E.  MORGAN,  one of our directors since 1987, is a co-founder,
Chairman  and Chief Executive Officer of incuVest LLC and a Managing Partner and
co-founder  of Amphion Capital Management LLC. Prior to founding Amphion, he was
Managing  General  Partner  of  Wolfensohn  Partners,  L.P.,  the predecessor to
Amphion  Ventures  L.P.  Mr.  Morgan  also  serves  as Chairman of AXCESS, Inc.,
Quidel  Corp.,  ONTOS, Inc., IVEX Corporation and Quantrad, Inc. In addition, he
serves  on  the  Board  of  Directors  of ChromaVision Medical Systems, Inc. and
Indigo NV.

     WALTER  L. ROBB, PH.D., one of our directors since 1992, has been a private
consultant  and  President of Vantage Management Inc., a consulting and investor
services  company,  since  January  1993. Mr. Robb was Senior Vice President for
Corporate  Research and Development of General Electric Company, and a member of
its  Corporate  Executive  Council  from 1986 to December 1992. Mr. Robb also is
Chairman  of the board of directors of Capital District Sports and a director of
Cree Research Inc., Mechanical Technology, Inc. and Plug Power, Inc.

     LEE  J.  SCHROEDER,  one of our directors since 1995, has been President of
Lee  Schroeder  &  Associates,  Inc., pharmaceutical business consultants, since
1985.  Mr.  Schroeder  was President of Fox Meyer Lincoln from 1983 to 1985, and
was  an  Executive  Vice  President  of  Sandoz,  Inc.  from  1981  to 1983. Mr.
Schroeder  also  is  a director of Bryan LGH Hospital, MGI Pharmaceutical, Inc.,
Ascent Pediatrics, Inc. and Interneuron Pharmaceuticals, Inc.

ELECTION OF DIRECTORS

     Each  director  holds office (subject to our By-Laws) until the next annual
meeting  of  stockholders  and  until such director's successor has been elected
and  qualified.  There  are no family relationships between any of the directors
and executive officers of the Company.

                                       30
<PAGE>

ITEM 11. EXECUTIVE COMPENSATION.

                           SUMMARY COMPENSATION TABLE

     The  following table sets forth information about the compensation paid, or
payable,  by  the  Company  for services rendered in all capacities to the Chief
Executive  Officer  of  the  Company  and each of the most highly paid executive
officers  of  the  Company  who  earned more than $100,000, for each of the last
three  fiscal  years  in  which such officers were executive officers for all or
part of the year.

<TABLE>
<CAPTION>
                                         ANNUAL COMPENSATION                       LONG-TERM COMPENSATION
                             ------------------------------------------- -------------------------------------------
                                                           OTHER ANNUAL    RESTRICTED    SECURITIES     ALL OTHER
       NAME AND                                            COMPENSATION       STOCK      UNDERLYING    COMPENSATION
  PRINCIPAL POSITION   YEAR     SALARY ($)     BONUS ($)        ($)       AWARD(S) ($)    OPTIONS #        ($)
- --------------------- ------ ---------------- ----------- -------------- -------------- ------------ ---------------
<S>                   <C>    <C>              <C>         <C>            <C>            <C>          <C>
John W. Jackson       1999        300,000       390,000       19,200(1)        0           220,000        13,390(2)
 Chairman and         1998        285,000        79,800       19,200(1)        0           100,000        13,390(2)
 Chief Executive      1997        270,000        97,200        9,500(1)        0                 0        13,390(2)
 Officer
Sol J. Barer, Ph.D.   1999        255,833       230,250       19,200(1)        0            70,000             0
 President and        1998        243,333        51,100       19,200(1)        0            50,000             0
 Chief Operating      1997        232,500        63,647        9,500(1)        0                 0             0
 Officer
Robert J. Hugin       1999        127,385(3)    168,000        7,200           0           150,000             0
 Sr. V. P. & Chief
 Financial Officer
</TABLE>

- ----------
(1) Reflects matching contributions under the Company's 401K plan.

(2) Reflects  life  insurance  premiums  for  a  life  insurance  policy for Mr.
    Jackson.

(3) Mr. Hugin commenced his employment with the Company in June, 1999.


EMPLOYMENT AGREEMENTS AND TERMINATION OF EMPLOYMENT ARRANGEMENTS

     John  W.  Jackson,  Sol  J. Barer and Robert J. Hugin (each an "Executive")
are  employed  pursuant  to  substantially  similar  employment  agreements (the
"Employment  Agreements") providing for their continued employment until January
1,  2003  (the  period  during which Executive is employed is referred to as the
"Employment  Period").  The Employment Period shall be automatically renewed for
successive  one-year  terms unless the Company or Executive gives written notice
to  the  other  at  least  six  months prior to the expiration of the Employment
Period.  The Employment Agreements provide Messrs. Jackson, Barer and Hugin with
a  base salary (which may be increased by the Board of Directors, or a committee
thereof)  of  $300,000,  $258,000  and  $240,000,  respectively,  per  annum. In
addition,  each  of the Employment Agreements provides for an annual bonus in an
amount  equal  to  65%,  45%  and  35%, respectively, of Executive's base salary
measured  against objective criteria to be determined by the Board of Directors,
or  a  committee  thereof after good faith consultation with each Executive. The
Employment  Agreements  also  provide  that Messrs. Jackson, Barer and Hugin are
entitled  to  continue to participate in all group health and insurance programs
and  all  other fringe benefit or retirement plans which are generally available
to  the  Company's employees. Each of the Employment Agreements provides that if
the  Executive  is terminated by the Company without cause or due to Executive's
disability,  he  shall  be  entitled  to receive a lump-sum payment in an amount
equal  to  Executive's  annual  base  salary and a pro rata share of Executive's
annual  target  bonus. Upon the occurrence of a change in control (as defined in
the  Employment  Agreements)  and thereafter, each Employment Agreement provides
that  if,  (a)  at  any  time within one year of a change in control Executive's
employment  is  terminated  by the Company without cause or for disability or by
Executive  for  good  reason  (as defined in the Employment Agreement) or (b) at
any  time within 90 days prior to a change in control, Executive's employment is
terminated  by  the  Company  without  cause  or  by  Executive for good reason,
Executive  shall  be  entitled  to  receive: (i) a lump sum payment in an amount
equal to three times Executive's base salary and three


                                       31
<PAGE>

times  Executive's  highest  annual  bonus  within  the three years prior to the
change  in  control;  (ii)  any  accrued  benefits;  (iii) payment of health and
welfare  premiums  for Executive and his dependants; and (iv) full and immediate
vesting  of  all  stock  options and equity awards; provided, however, that such
payment  shall  be reduced by any payments made to Executive prior to the change
in  control pursuant to Sections 10(a)(iv) and (v) of the Employment Agreements.
Each  Employment  Agreement  also  provides  that Executive shall be entitled to
receive  a  gross-up  payment on any payments made to Executive that are subject
to  the  excise tax imposed by Section 4999 of the Internal Revenue Code, except
that  a  gross-up  will  not  be  made  if the payments made to Executive do not
exceed  105%  of  the  greatest amount that could be paid to Executive such that
the  receipt  of  payments would not give rise to the excise tax. Each Executive
is  subject  to  a  non-compete which applies during the period the Executive is
employed  and  until  the  first  anniversary of the date Executive's employment
terminates  (the  non-compete  applies  to  the  second  anniversary of the date
Executive's  employment  terminates  if the Executive receives change in control
payments and benefits).

STOCK OPTIONS

     The  following table sets forth information for each of the named executive
officers  with  respect  to the value of options exercised during the year ended
December  31,  1999 and the value of outstanding and unexercised options held as
of  December  31,  1999.  There were no SARs exercised during 1999 and none were
outstanding as of December 31, 1999.

       AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR-END
                                 OPTION VALUES

<TABLE>
<CAPTION>
                                                                NUMBER OF
                                                          SECURITIES UNDERLYING         VALUE OF UNEXERCISED
                                  SHARES                   UNEXERCISED OPTIONS          IN-THE-MONEY OPTIONS
                                 ACQUIRED     VALUE       AT DECEMBER 31, 1999          AT DECEMBER 31, 1999
                               ON EXERCISE   REALIZED ----------------------------- ----------------------------
             NAME                  ($)         ($)     EXERCISABLE   UNEXERCISABLE   EXERCISABLE   UNEXERCISABLE
- ----------------------------- ------------- --------- ------------- --------------- ------------- --------------
<S>                           <C>           <C>       <C>           <C>             <C>           <C>
John W. Jackson .............      --          --        206,423       286,667       $11,850,905   $15,640,820
Sol J. Barer, Ph.D. .........      --          --        250,746       103,334       $10,205,964   $ 5,740,441
Robert J. Hugin .............      --          --             --       150,000                --   $ 8,156,250
</TABLE>

- ----------
(1) Represents  the  difference  between  the closing market price of the Common
    Stock  as  reported  by Nasdaq on December 31, 1999 of $70 per share and the
    exercise  price  per  share of in-the-money options multiplied by the number
    of shares underlying the in-the-money options.

COMPENSATION COMMITTEE REPORT

     The  Compensation Committee determines our executive compensation policies.
The   Compensation  Committee  determines  the  compensation  of  our  executive
officers  and approves and oversees the administration of incentive compensation
programs  for  all  employees  including  executive  officers.  The Compensation
Committee is composed solely of outside directors.

EXECUTIVE COMPENSATION POLICIES AND PROGRAMS

     Our  executive  compensation  program  is  part  of  a company-wide program
covering  all  employees.  The  program's  goals  are  to  attract,  retain, and
motivate   employees,  and  it  utilizes  incentives  such  that  employees  and
stockholders  share the same risks. The compensation program is designed to link
compensation to performance.

     A  portion  of  each  employee's compensation relates to the grant of stock
options,  and  such  grants  are based on the successful attainment of strategic
corporate, commercial, and individual goals.

     We  do  not  have  a  pension  plan  or other capital accumulation program.
Grants  of stock options are therefore of great importance to executives as well
as  all  employees.  Any  long-term value to be derived from such grants will be
consistent with stockholder gains.


                                       32
<PAGE>

     Executive  and  employee  compensation  includes salary, employment-related
benefits, and long-term incentive compensation:

     Salary.  Salaries  are  set competitively relative to the biotechnology and
pharmaceutical  industries--industries  with  which  we  compete  for our highly
skilled  personnel.  Individual  experience  and  performance is considered when
setting  salaries  within  the  range for each position. Annual reviews are held
and adjustments are made based on attainment of individual goals.

     Benefits.  All employees are eligible for similar benefits, such as health,
disability, and life insurance.

     Long-Term  Incentive  Compensation.  An  incentive  compensation program is
established  annually.  The  purpose  of  this  program  is to provide financial
incentives  to  executives  and  employees to achieve annual corporate, business
unit,  and  individual  goals.  The  incentive program also aligns executive and
employee  interests with those of stockholders by using grants of stock options.
Such  grants  vest  over  time thereby encouraging continued employment with the
Company.  The  size  of  grants  is  tied  to comparative biotechnology industry
practices.  To  determine  such  comparative data, the Company relies on outside
compensation consultants and third party industry surveys.

     Under  our 1998 incentive program, it was agreed that each year, subject to
the  achievement  of  certain  goals  by  the Company, we would grant at certain
dates  pursuant  to  approval  of  the  compensation  committee  of the Board of
Directors,  options  to  purchase  shares  of  common stock. A similar incentive
program  has  been  designed for 1999 based on attainment of corporate, business
unit,  and  individual  goals.  The  program  is  open  to all regular full-time
employees, other than the executive officers of the Company.

     Chief  Executive  Officer  Compensation. Pursuant to Mr. Jackson's contract
with  the  Company entered into on September 30, 1997, Mr. Jackson received base
salary  of  $300,000 for 1999. Mr. Jackson also received a bonus of $390,000 for
1999.  Factors  considered  in  determining  Mr.  Jackson's  bonus  included the
successful  attainment of several important milestones in the development of our
products,  as  well  as  comparisons  to  total  compensation  packages of chief
executive  officers  at  corporations within our industry that are of comparable
size.

                     Members of the Compensation Committee

                           Richard C. E. Morgan, Chairman
                           Frank T. Cary
                           Jack L. Bowman
                           Lee J. Schroeder

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The  current  members  of  the  Compensation  Committee  are  Richard C. E.
Morgan,  Chairman,  Frank T. Cary, Jack L. Bowman, and Lee J. Schroeder. Each is
an outside director of the Company.

DIRECTOR COMPENSATION

     Directors  do  not  receive  salaries or cash fees for serving as directors
nor  do  they  receive any cash compensation for serving on committees; however,
all  members  of  the  Board  of  Directors who are not employees of the Company
("Non-Employee  Directors")  are  reimbursed for their expenses for each meeting
attended  and  are  eligible  to  receive  stock  options  pursuant  to the 1995
Non-Employee Directors' Plan (the "1995 Directors' Plan").

     The  1995 Directors' Plan was adopted by the Board of Directors on April 5,
1995,  and  approved by the Company's stockholders at the 1995 Annual Meeting of
Stockholders.   The   1995   Directors'   Plan  provides  for  the  granting  to
Non-Employee  Directors of non-qualified options to purchase an aggregate of not
more  than  250,000  shares  (subject to adjustment in certain circumstances) of
Common Stock.

     Under  the  1995 Directors' Plan, each Non-Employee Director as of April 5,
1995  was  granted  a  non-qualified  option to purchase 20,000 shares of Common
Stock,  and  each  new  Non-Employee  Director  upon the date of his election or
appointment  will be granted a non-qualified option to purchase 20,000 shares of
Common  Stock.  These  initial  options  vest  in four equal annual installments
commencing  on  the  first  anniversary  of  the  date  of  grant,  assuming the
Non-Employee Director remains a director.


                                       33
<PAGE>

     Upon  the  date  of  each Annual Meeting of Stockholders, each Non-Employee
Director  is  granted a non-qualified option to purchase 10,000 shares of Common
Stock  (or  a  pro rata portion thereof if the director did not serve the entire
year  since  the date of the last annual meeting). These options vest in full on
the  date of the first Annual Meeting of Stockholders held following the date of
the grant, assuming the Non-Employer Director is a director on that date.

     All  options  granted  pursuant  to the 1995 Directors' Plan will expire no
later  than  10 years from the date of grant and no options may be granted after
June  16,  2005.  If a Non-Employee Director terminates his service on the Board
of  Directors  for  any  reason,  options  which were exercisable on the date of
termination  and  which  have not expired may be exercised at any time until the
date  of  expiration  of  such  options.  In  addition,  if there is a change of
control  and within two years thereafter a director is removed without cause (as
defined)  or  is  not  nominated for election by the Company's stockholders, all
unvested portions of a stock option will automatically vest.

     In  1999,  pursuant  to  the  1995 Directors' Plan, each of Messrs. Bowman,
Cary,  Hayes,  Morgan,  Robb,  Schroeder  and  Dr.  Kaplan received an option to
purchase  10,000  shares  of  Common  Stock  at an exercise price of $15.625 per
share, the fair market value of the stock on the date of the grant.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT.

     The  table below sets forth the beneficial ownership of the Common Stock as
of  February  29, 2000 (i) by each director, (ii) by each of the named executive
officers,  (iii)  by all directors and executive officers of Celgene as a group,
and  (iv) by all persons known by the Board of Directors to be beneficial owners
of more than five percent of the outstanding shares of Common Stock.

<TABLE>
<CAPTION>
                                                                      AMOUNT AND NATURE
                                                                        OF BENEFICIAL        PERCENT OF
                              NAME                                        OWNERSHIP            CLASS
- ----------------------------------------------------------------   ----------------------   -----------
<S>                                                                <C>                      <C>
John W. Jackson ................................................           388,133(1)            1.8%
Sol J. Barer, Ph.D. ............................................           232,427(1)(2)         1.1%
Robert J. Hugin ................................................            11,667(1)              *
Frank T. Cary ..................................................            97,780                 *
Arthur Hull Hayes, Jr., M.D ....................................            40,000(1)              *
Richard C. E. Morgan ...........................................            79,090(1)(3)           *
Walter L. Robb, Ph.D. ..........................................           100,000(1)              *
Lee J. Schroeder ...............................................            56,000(1)              *
Gilla Kaplan, Ph.D. ............................................            16,700(1)              *
Jack L. Bowman .................................................            12,700(1)              *
All directors and current executive officers of the Company as a
 group (ten persons) ...........................................         1,034,497(4)            4.7%
Donald P. Moriarty (5)
 c/o McGrath, Doyle & Phair
 150 Broadway
 New York, NY 10038 ............................................         1,122,500 (5)           5.3%
Pilgrim Baxter & Associates Ltd.
 825 Duportail Road
 Wayne, PA 19087 ...............................................         1,084,500(6)            5.1%
</TABLE>

- ----------
* Less than one percent (1%).

(1) Includes  shares  of Common Stock which the directors and executive officers
    have  the  right  to  acquire through the exercise of options within 60 days
    of  February  29, 2000, as follows: John W. Jackson -- 327,123; Sol J. Barer
    --  232,412;  Robert  J.  Hugin  --  11,667; Frank T. Cary -- 0; Arthur Hull
    Hayes,  Jr.  --  40,000;  Richard  C.  E. Morgan -- 25,000 shares; Walter L.
    Robb  --  64,000;  Lee  J. Schroeder -- 20,000; Gilla Kaplan -- 16,700; Jack
    Bowman  --  11,700.  Does  not  include  shares  of  Common  Stock which the
    directors  and  executive  officers  had  the  right  to acquire through the
    exercise of options not exercisable within 60 days


                                       34
<PAGE>

  of  February  29,  2000,  as follows: John W. Jackson -- 246,667; Sol J. Barer
  --  96,668;  Robert  J. Hugin -- 173,333; Frank T. Cary -- 10,000; Arthur Hull
  Hayes,  Jr.  --  10,000;  Richard  C.  E.  Morgan -- 10,000; Walter L. Robb --
  10,000;  Lee  J.  Schroeder  --  10,000;  Gilla  Kaplan -- 25,333; and Jack L.
  Bowman -- 20,000.

(2) Includes  with  respect to Dr. Barer, 15 shares owned by the daughter of Dr.
    Barer, as to which shares Dr. Barer disclaims beneficial ownership.

(3) Includes  with  respect  to Mr.  Morgan,  90 shares  owned by the son of Mr.
    Morgan, as to which shares Mr. Morgan disclaims beneficial ownership.

(4) Includes  or  excludes,  as the  case  may be,  shares  of  Common  Stock as
    indicated in the preceding footnotes.

(5) Information  regarding  Donald P. Moriarty was obtained from a Schedule 13D,
    as  amended,  filed  with  the  Securities  and  Exchange  Commission.  Such
    Schedule  13D  states that Mr. Moriarty is deemed to be the beneficial owner
    of  and  to  have  sole  dispositive  power  over  all such shares of Common
    Stock,  and  that  such shares are held by Mr. Moriarty, his family members,
    and  Twin  Oaks  Partners,  a partnership in which Mr. Moriarty is a general
    partner.

(6) Information  regarding  Pilgrim Baxter & Associates Ltd. was obtained from a
    Schedule  13G,  filed  by  it  with  the Securities and Exchange Commission.
    Such  Schedule  13G  states  that  Pilgrim  Baxter  & Associates Ltd. is the
    beneficial  owner  of  and  has  the  sole  dispositive  power over all such
    shares  of  Common  Stock  and  has  sole voting power over 852,500 of those
    shares.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

     None.

                                    PART IV


ITEM 14. EXHIBITS, FINANCIAL STATEMENTS, AND REPORTS ON FORM 8-K.

     (a)(1),   (a)(2)   See  Index  to  Consolidated  Financial  Statements  and
Consolidated Financial Statement Schedule immediately following Exhibit Index.

     (b) None

     (c) Exhibits

     The following exhibits are filed with this report:


<TABLE>
<CAPTION>
 EXHIBIT
   NO.                                       EXHIBIT DESCRIPTION
- --------   ---------------------------------------------------------------------------------------
<S>        <C>
 3.1       Certificate of Incorporation of the Company, as amended (incorporated by reference to
           Exhibit 3.1 to the Company's Registration Statement on Form S-1, dated July 24, 1987).
 3.2       Bylaws of the Company (incorporated by reference to the Company's Current Report
           on Form 8K, dated September 16, 1996).
10.1       Lease Agreement, dated January 16, 1987, between the Company and Powder Horn
           Associates (incorporated by reference to Exhibit 10.17 to the Company's Registration
           Statement on Form S-1, dated July 24, 1987).
10.2       1992 Long-Term Incentive Plan (incorporated by reference to Exhibit A to the
           Company's Proxy Statement, dated May 30, 1997).
10.3       1995 Non-Employee Directors' Incentive Plan (incorporated by reference to Exhibit A
           to the Company's Proxy Statement, dated May 24, 1999).
10.4       Agent's Warrant issued in connection with the placement of 8% Convertible Debentures
           (incorporated by reference to Exhibit 10.2 to the Company's Quarterly Report on Form
           10Q for the quarter ended June 30, 1995).
</TABLE>

                                       35
<PAGE>


<TABLE>
<CAPTION>
<S>         <C>
            Agent's Warrant issued in connection with the placement of Series A Convertible
            Preferred Stock (incorporated by reference to the Company's Annual Report on Form
10.5        10K for the year ended December 31, 1995).

10.6        Form of Lock-Up Warrant issued to certain holders of Series A Convertible Preferred
            Stock (incorporated by reference to the Company's Registration Statement on Form S-3
            dated November 25, 1997 (No. 333-38891)).
10.7        Form of Warrant to be issued in connection with the issuance of Series B Convertible
            Preferred Stock (incorporated by reference to Exhibit 10.2 to the Company's Current
            Report on Form 8K dated June 10, 1997).
10.8        Rights Agreement, dated as of September 16, 1996, between Celgene Corporation and
            American Stock Transfer & Trust Company (incorporated by reference to the
            Company's Registration Statement on Form 8A, filed on September 16, 1996).
10.9        Form of indemnification agreement between the Company and each officer and director
            of the Company (incorporated by reference to Exhibit 10.12 to the Company's Annual
            Report on Form 10K for the year ended December 31, 1996).
10.10       Employment Agreement dated as of January 1, 2000 between the Company and John W.
            Jackson.
10.11       Employment Agreement dated as of January 1, 2000 between the Company and Sol J.
            Barer.
10.12       Manufacturing Agreement between Penn Pharmaceuticals Limited and the Company
            (incorporated by reference to the Company's Registration Statement on Form S-3 dated
            November 25, 1997 (No. 333-38891)).
10.13       Celgene Corporation Replacement Stock Option Plan (incorporated by reference to
            Exhibit 99.1 of the Company's Registration Statement on Form S-3 dated May 18, 1998
            (No. 333-52963)).
10.14       Form of Stock Option Agreement to be issued in connection with the Celgene
            Corporation Replacement Stock Option Plan (incorporated by reference to Exhibit 99.2
            of the Company's Registration Statement on Form S-3 dated May 18, 1998 (No.
             333-52963)).
10.15       1998 Long Term-Incentive Plan (incorporated by reference to Exhibit A to the
            Company's Proxy Statement, dated May 18, 1998).
10.16       Stock Purchase Agreement dated June 23, 1998 between the Company and Biovail
            Laboratories Incorporated (incorporated by reference to the Company's Current Report
            on Form 8K filed on July 17, 1998 (No. 000-16132)).
10.17       Agreement dated December 9, 1998 between the Company and EntreMed, Inc. (certain
            portions of the agreement have been omitted and filed separately with the United States
            Securities and Exchange Commission pursuant to a request for confidential treatment.
10.18       Employment Agreement dated as of January 1, 2000 between the Company and Robert
            J. Hugin.
10.19       Convertible Note Purchase Agreement, dated September 16, 1998 between the
            Company and Warburg Dillon Read LLC.
10.20       9.25% Convertible Note Due September 16, 2003.
10.21       Registration Rights Agreement dated as of September 16, 1998 between the Company
            and Warburg Dillon Read LLC.
</TABLE>

                                       36
<PAGE>


<TABLE>
<CAPTION>
<S>          <C>
  10.22      Note Purchase Agreement dated January 20, 1999 between the Company and the
             Purchasers named on Schedule I to the agreement in connection with the purchase of
             $15,000,000 principal amount of the Company's 9.00% Senior Convertible Note Due
             January 20, 2004.

  10.23      Form of 9.00% Senior Convertible Note Due January 20, 2004.
  10.24      Registration Rights Agreement dated as of January 20, 1999 between the Company and
             the Purchasers in connection with the issuance of the Company's 9.00% Senior
             Convertible Note Due January 20, 2004.
  10.25      Note Purchase Agreement dated July 6, 1999 between the Company and the Purchasers
             named in Schedule I to the agreement in connection with the purchase of $15,000,000
             principal amount of the Company's 9.00% Senior Convertible Note Due June 30, 2004.
  10.26      Form of 9.00% Senior Convertible Note Due June 30, 2004.
  10.27      Registration Rights Agreement dated as of July 6, 1999 between the Company and the
             Purchasers in connection with the issuance of the Company's 9.00% Senior Convertible
             Note Due June 30, 2004.
  23.1       Consent of KPMG LLP
  24.1       Power of Attorney (included in Signature Page).
* 27.        Financial Data Schedule
</TABLE>

- ------------------
* Previously Filed

                                       37
<PAGE>

                       SIGNATURES AND POWER OF ATTORNEY

     KNOW  ALL MEN BY THESE PRESENTS, that each person or entity whose signature
appears  below constitutes and appoints John W. Jackson, Sol J. Barer and Robert
J.  Hugin,  and  each of them, its true and lawful attorneys-in-fact and agents,
with  full  power  of  substitution  and resubstitution, for it and in its name,
place  and  stead,  in any and all capacities, to sign any and all amendments to
this  Form  10-K  and  to  file  the  same, with all exhibits thereto, and other
documents  in connection therewith, with the Securities and Exchange Commission,
granting  unto  said  attorneys-in-fact and agents, and each of them, full power
and  authority  to  do  and  perform  each and every act and thing requisite and
necessary  to  be  done,  as  fully  to all contents and purposes as it might or
could   do   in   person,   hereby   ratifying  and  confirming  all  that  said
attorneys-in-fact  and  agents,  or  any  of them, or their or his substitute or
substitutes may lawfully do or cause to be done by virtue thereof.

     Pursuant  to  the  requirements  of  Section 13 or 15 (d) of the Securities
Exchange  Act  of  1934, the registrant has duly caused this report to be signed
on its behalf by the undersigned thereunto duly authorized.

                                        CELGENE CORPORATION


                                        By /s/ John W. Jackson
                                           -----------------------------
                                           John W. Jackson
                                           Chairman of the Board and
                                           Chief Executive Officer

Date: March 30, 2000

     Pursuant  to  the requirements of the Securities Exchange Act of 1934, this
report  has  been  signed  below  by  the  following  persons  on  behalf of the
registrant and in the capacities and on the dates indicated.


<TABLE>
<CAPTION>
            SIGNATURE                               TITLE                          DATE
- --------------------------------   ---------------------------------------   ---------------
<S>                                <C>                                       <C>
    /s/ John W. Jackson            Chairman of the Board and                 March 30, 2000
 ---------------------------        Chief Executive Officer
        John W. Jackson

      /s/ Sol J. Barer             President and Chief Operating Officer     March 30, 2000
 ---------------------------
          Sol J. Barer

      /s/ Jack L. Bowman            Director                                 March 30, 2000
 ---------------------------
          Jack L. Bowman

      /s/ Frank T. Cary             Director                                 March 30, 2000
 ---------------------------
          Frank T. Cary

                                    Director                                 March 30 2000
 ---------------------------
       Arthur Hull Hayes, Jr.

      /s/ Gilla Kaplan              Director                                 March 30, 2000
 ---------------------------
          Gilla Kaplan

   /s/ Richard C.E. Morgan          Director                                 March 30, 2000
 ---------------------------
       Richard C. E. Morgan
</TABLE>

<PAGE>


<TABLE>
<CAPTION>
<S>                              <C>                                       <C>
    /s/ Walter L. Robb
- ---------------------------
        Walter L. Robb              Director                                 March 30, 2000

                                    Director                                 March 30, 2000
 ---------------------------
        Lee J. Schroeder

    /s/ Robert J. Hugin             Senior Vice President & Chief           March 30, 2000
 ---------------------------          Financial Officer
        Robert J. Hugin

   /s/ James R. Swenson             Controller (Chief Accounting Officer)   March 30, 2000
 ---------------------------
       James R. Swenson

</TABLE>

     The foregoing constitutes a majority of the directors.
<PAGE>

                              CELGENE CORPORATION

                   INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

<TABLE>
<CAPTION>
                                                                                            PAGE
                                                                                           -----
<S>                                                                                        <C>
Consolidated Financial Statements
 Independent Auditors' Report ............................................................ F-2
 Consolidated Balance Sheets as of December 31, 1998 and 1999 ............................ F-3
 Consolidated Statements of Operations - Years Ended December 31, 1997, 1998, and 1999 ... F-4
 Consolidated Statements of Stockholders' Equity (Deficit) - Years Ended December 31,
1997,98 and 1999 ......................................................................... F-5
 Consolidated Statements of Cash Flows - Years Ended December 31, 1997, 1998 and 1999 .... F-6
 Notes to Consolidated Financial Statements .............................................. F-8
Consolidated Financial Statement Schedule
 Schedule II - Valuation and Qualifying Accounts ......................................... F-20

</TABLE>

                                      F-1
<PAGE>

                         INDEPENDENT AUDITORS' REPORT


The Board of Directors and Stockholders
CELGENE CORPORATION:


     We  have  audited  the   consolidated   financial   statements  of  Celgene
Corporation  and subsidiary as listed in the  accompanying  index. In connection
with our audits of the consolidated  financial statements,  we also have audited
the  consolidated  financial  statement  schedule as listed in the  accompanying
index.  These  consolidated  financial  statements  and  consolidated  financial
statement  schedule are the  responsibility  of the  Company's  management.  Our
responsibility  is  to  express  an  opinion  on  these  consolidated  financial
statements and consolidated financial statement schedule based on our audits.

     We  conducted  our  audits  in  accordance with generally accepted auditing
standards.  Those standards require that we plan and perform the audit to obtain
reasonable  assurance  about  whether  the  financial  statements  are  free  of
material  misstatement.  An  audit includes examining, on a test basis, evidence
supporting  the  amounts  and  disclosures in the financial statements. An audit
also   includes   assessing  the  accounting  principles  used  and  significant
estimates  made  by  management,  as  well  as  evaluating the overall financial
statement  presentation.  We  believe that our audits provide a reasonable basis
for our opinion.

     In  our  opinion,  the  consolidated financial statements referred to above
present  fairly,  in  all  material  respects, the financial position of Celgene
Corporation  and subsidiary as of December 31, 1998 and 1999, and the results of
their  operations  and  their cash flows for each of the years in the three-year
period   ended   December  31,  1999,  in  conformity  with  generally  accepted
accounting  principles.  Also in our opinion, the related consolidated financial
statement  schedule,  when  considered  in  relation  to  the basic consolidated
financial  statements  taken  as  a  whole,  presents  fairly,  in  all material
respects, the information set forth therein.


                                        /s/ KPMG LLP


Short Hills, New Jersey
January 27, 2000, except
as to note 14, which is as
of February 16, 2000

                                      F-2
<PAGE>

                              CELGENE CORPORATION
                          CONSOLIDATED BALANCE SHEETS


<TABLE>
<CAPTION>
                                                                                   DECEMBER 31,
                                                                        -----------------------------------
                                                                               1998              1999
                                                                        ----------------- -----------------
<S>                                                                     <C>               <C>
ASSETS
Current assets:
   Cash and cash equivalents ..........................................  $    3,066,953    $   15,255,422
   Marketable securities available for sale ...........................       2,056,890         4,271,221
   Accounts receivable, net of allowance of $43,386 and $121,437 at
    December 31, 1998 and 1999, respectively ..........................       2,662,389         4,928,472
   Inventory ..........................................................       1,571,408         2,456,059
   Other current assets ...............................................         229,060           895,602
                                                                         --------------    --------------
      Total current assets ............................................       9,586,700        27,806,776
   Plant and equipment, net ...........................................       2,262,130         2,336,242
   Other assets .......................................................          79,167         2,190,652
                                                                         --------------    --------------
      Total assets ....................................................  $   11,927,997    $   32,333,670
                                                                         ==============    ==============

LIABILITIES AND STOCKHOLDERS' DEFICIT
Current liabilities:
   Accounts payable ...................................................  $    3,848,853    $    2,358,563
   Accrued expenses ...................................................       3,041,859         6,761,889
   Capitalized lease obligation .......................................         225,372           179,885
                                                                         --------------    --------------
      Total current liabilities .......................................       7,116,084         9,300,337
   Capitalized lease obligation-net of current portion ................         195,578            22,924
   Other non-current liabilities ......................................              --           225,000
   Long term convertible notes ........................................       8,348,959        38,494,795
                                                                         --------------    --------------
      Total liabilities ...............................................      15,660,621        48,043,056
                                                                         --------------    --------------
Stockholders' deficit:
   Preferred stock,$.01 par value per share 5,000,000 authorized; none
    outstanding at December 31,1998 and 1999 ..........................
   Common stock, $.01 par value per share 30,000,000 authorized; issued
    and outstanding 16,612,973 and 17,703,646 shares at December 31,
    1998 and December 31,1999, respectively ...........................         166,130           177,036
   Additional paid-in capital .........................................     140,714,314       150,599,750
   Accumulated deficit ................................................    (144,613,068)     (166,394,268)
   Accumulated other comprehensive loss ...............................              --           (91,904)
                                                                         --------------    --------------
      Total stockholders' deficit .....................................      (3,732,624)      (15,709,386)
                                                                         --------------    --------------
      Total liabilities and stockholders' deficit .....................  $   11,927,997    $   32,333,670
                                                                         ==============    ==============

</TABLE>

See accompanying notes to consolidated financial statements.



                                      F-3
<PAGE>

                              CELGENE CORPORATION
                     CONSOLIDATED STATEMENTS OF OPERATIONS



<TABLE>
<CAPTION>
                                                                YEARS ENDED DECEMBER 31,
                                                 -------------------------------------------------------
                                                       1997               1998                1999
                                                 ----------------   ----------------   -----------------
<S>                                              <C>                <C>                <C>
Revenues:
 Product sales ...............................    $          --      $   3,265,490       $  24,052,124
 Research contracts ..........................        1,122,193            535,000           2,157,500
                                                  -------------      -------------       -------------
   Total revenues ............................        1,122,193          3,800,490          26,209,624
                                                  -------------      -------------       -------------
Expenses: ....................................
 Cost of goods sold ..........................               --            282,307           2,982,713
 Research and development ....................       17,380,390         19,771,953          19,646,129
 Selling, general and administrative .........        9,145,456         16,218,486          26,235,802
                                                  -------------      -------------       -------------
    Total expenses ...........................       26,525,846         36,272,746          48,864,644
                                                  -------------      -------------       -------------
Operating loss ...............................      (25,403,653)       (32,472,256)        (22,655,020)
Other income and expense:
 Interest income .............................          495,580            705,215             694,390
 Interest expense ............................          111,771            255,832           2,838,480
                                                  -------------      -------------       -------------
Loss before tax benefit ......................      (25,019,844)       (32,022,873)        (24,799,110)
Tax benefit (note 9) .........................               --                 --           3,017,910
                                                  -------------      -------------       -------------
Loss from continuing operations ..............      (25,019,844)       (32,022,873)        (21,781,200)
Discontinued operations: (note 10)
 Loss from operations ........................         (427,183)           (59,837)                 --
 Gain on sale of chiral assets ...............               --          7,014,830                  --
                                                  -------------      -------------       -------------
Net loss .....................................      (25,447,027)       (25,067,880)        (21,781,200)
Accretion of premium payable on
 preferred stock and warrants ................          521,397             24,648                  --
Deemed dividend for preferred stock
 conversion discount .........................          953,077                 --                  --
                                                  -------------      -------------       -------------
Net loss applicable to common
 stockholders ................................    $ (26,921,501)     $ (25,092,528)      $ (21,781,200)
                                                  =============      =============       =============
Per share basic and diluted: (note 2)
 Loss from continuing operations .............    $       (2.05)     $       (1.98)      $       (1.28)
 Discontinued operations:
   Loss from operations ......................          (  0.03)           (  0.00)                 --
   Gain on sale of chiral assets .............               --               0.43                  --
 Net loss applicable to common
   stockholders ..............................    $       (2.20)     $       (1.55)      $       (1.28)
                                                  =============      =============       =============
Weighted average number of shares of
 common stock outstanding ....................       12,215,000         16,160,000          17,012,000
                                                  =============      =============       =============
</TABLE>

See accompanying notes to consolidated financial statements.



                                      F-4
<PAGE>

                              CELGENE CORPORATION
           CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)
                 YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999

<TABLE>
<CAPTION>
                                                    COMMON STOCK              PREFERRED STOCK              TREASURY STOCK
                                              ------------------------ ---------------------------- ---------------------------
                                                 SHARES       AMOUNT      SHARES        AMOUNT         SHARES        AMOUNT
                                              ------------ ----------- ----------- ---------------- ------------ --------------
<S>                                           <C>          <C>         <C>         <C>              <C>          <C>
Balances at January 1, 1997 .................  10,611,422   $106,114         267    $   13,883,416     (29,985)    $ (100,239)
Exercised stock options .....................       2,986         30
Shares issued in lieu of cash bonus .........       5,000         50
Amortization of deferred compensation .
Conversion of convertible debenture ........     441,248      4,412
Issuance of Series B Preferred Stock - net                                 5,000         4,046,923
Conversion of preferred stock ...............   2,166,193     21,662      (5,180)      (14,654,071)
Accretion of premium on preferred stock                                                    521,397
Redemption of preferred stock ...............                                (13)         (721,287)
Deemed dividend on Series B Preferred
 Stock and fair value of warrants ...........                                              953,077
Comprehensive loss:
 Net loss ...................................
 Net change in unrealized gain (loss) on
 investment securities ......................
Total comprehensive loss ....................
Treasury shares issued ......................                                                            7,097         23,704
Issuance of common stock, net ...............   2,201,100     22,011
                                               ----------   --------
Balances at December 31, 1997 ...............  15,427,949   $154,279          74    $    4,029,455     (22,888)    $  (76,535)
Exercised stock options .....................     283,120      2,831
Exercise of warrants ........................     118,230      1,183
Costs related to secondary offering .........
Conversion of preferred stock ...............     575,669      5,757         (74)       (4,054,103)
Accretion of premium on preferred stock                                                     24,648
Shares issued for employee benefit plans            8,317         83                                    22,888         76,535
Sale of common stock ........................     199,688      1,997
Net loss and comprehensive loss .............
Balances at December 31, 1998 ...............  16,612,973   $166,130          --    $           --          --     $       --
Exercised stock options .....................     949,323      9,493
Exercise of warrants ........................      59,434        594
Shares issued for employee benefit plans           81,916        819
Issuance of options related to license
 agreement ..................................
Comprehensive loss:
 Net loss ...................................
 Net change in unrealized gain (loss) on
 investment securities ......................
 Total comprehensive loss ...................
 Balances at December 31, 1999 ..............  17,703,646   $177,036          --    $           --          --     $       --
                                               ==========   ========      ======    ==============     =======     ==========



<CAPTION>
                                                                                                  ACCUMULATED
                                                                                                     OTHER
                                                 ADDITIONAL     UNAMORTIZED                      COMPREHENSIVE
                                                  PAID-IN        DEFERRED        ACCUMULATED        INCOME
                                                  CAPITAL      COMPENSATION        DEFICIT          (LOSS)           TOTAL
                                              --------------- -------------- ------------------ -------------- -----------------
<S>                                           <C>             <C>            <C>                <C>            <C>
Balances at January 1, 1997 .................  $ 94,770,176     $  (1,133)     $  (92,599,039)    $   5,714      $  16,065,009
Exercised stock options .....................        20,187                                                             20,217
Shares issued in lieu of cash bonus .........        55,575                                                             55,625
Amortization of deferred compensation .                             1,133                                                1,133
Conversion of connvertible debenture ........     2,326,892                                                          2,331,304
Issuance of Series B Preferred Stock - net          793,825                                                          4,840,748
Conversion of preferred stock ...............    14,632,409                                                                 --
Accretion of premium on preferred stock                                              (521,397)                              --
Redemption of preferred stock ...............                                                                         (721,287)
Deemed dividend on Series B Preferred
 Stock and fair value of warrants ...........                                        (953,077)                              --
Comprehensive loss:
 Net loss ...................................                                     (25,447,027)                     (25,447,027)
 Net change in unrealized gain (loss) on
 investment securities ......................                                                        (5,714)            (5,714)
                                                                                                                 -------------
Total comprehensive loss ....................                                                                      (25,452,741)
                                                                                                                 -------------
Treasury shares issued ......................        55,250                                                             78,954
Issuance of common stock, net ...............    18,184,119                                                         18,206,130
                                               ------------                                                      -------------
Balances at December 31, 1997 ...............  $130,838,433     $      --      $ (119,520,540)    $      --      $  15,425,092
Exercised stock options .....................     2,028,715                                                          2,031,546
Exercise of warrants ........................       986,883                                                            988,066
Costs related to secondary offering .........       (73,136)                                                           (73,136)
Conversion of preferred stock ...............     4,048,346                                                                 --
Accretion of premium on preferred stock                                               (24,648)                              --
Shares issued for employee benefit plans            387,070                                                            463,688
Sale of common stock ........................     2,498,003                                                          2,500,000
Net loss and comprehensive loss .............                                     (25,067,880)                     (25,067,880)
                                                                               --------------                    -------------
Balances at December 31, 1998 ...............  $140,714,314     $      --      $ (144,613,068)    $      --      $  (3,732,624)
Exercised stock options .....................     8,028,139                                                          8,037,632
Exercise of warrants ........................       361,398                                                            361,992
Shares issued for employee benefit plans            799,004                                                            799,823
Issuance of options related to license
 agreement ..................................       696,895                                                            696,895
Comprehensive loss:
 Net loss ...................................                                     (21,781,201)                     (21,781,201)
 Net change in unrealized gain (loss) on
 investment securities ......................                                                       (91,904)           (91,904)
 Total comprehensive loss ...................                                                                      (21,873,105)
                                                                                                                 -------------
 Balances at December 31, 1999 ..............  $150,599,750     $      --      $ (166,394,269)    $ (91,904)     $ (15,709,387)
                                               ============     =========      ==============     =========      =============
</TABLE>

See accompanying notes to consolidated financial statements.


                                      F-5
<PAGE>

                              CELGENE CORPORATION
                     CONSOLIDATED STATEMENTS OF CASH FLOWS


<TABLE>
<CAPTION>
                                                                                  YEARS ENDED DECEMBER 31,
                                                                  ---------------------------------------------------------
                                                                         1997                1998                1999
                                                                  -----------------   -----------------   -----------------
<S>                                                               <C>                 <C>                 <C>
Cash flows from operating activities:
Loss from continuing operations ...............................     $ (25,019,844)      $ (32,022,873)      $ (21,781,200)
Adjustments to reconcile loss from continuing operations
 to net cash used in operating activities:
   Depreciation ...............................................           380,364             812,555             993,389
   Provision for losses on accounts receivable ................                --              43,386              78,051
   Amortization of convertible debt costs .....................           126,577                  --                  --
   Amortization of deferred compensation ......................             1,133                  --                  --
   Interest on convertible debentures .........................            68,736                  --                  --
   Issuance of stock award ....................................            55,625                  --                  --
   Amortization of debt issuance costs ........................                --                  --             250,000
   Amortization of discount on convertible note ...............                --                  --             145,836
   Shares issued for employee benefit plans ...................            78,954             463,688             799,823
Change in current assets & liabilities:
 Increase in inventory ........................................                --          (1,571,408)           (884,651)
 Increase(decrease) in accounts payable and accrued
   expenses ...................................................          (379,091)          4,659,517           2,454,740
 Increase in accounts receivable ..............................        (1,051,789)         (1,275,391)         (2,344,133)
 (Increase)decrease in other assets ...........................           150,304             124,206            (416,544)
                                                                    -------------       -------------       -------------
Net cash used in continuing operations ........................       (25,589,031)        (28,766,320)        (20,704,689)
Net cash used in discontinued operations ......................          (302,996)            (59,837)                 --
                                                                    -------------       -------------       -------------
Net cash used in operating activities .........................       (25,892,027)        (28,826,157)        (20,704,689)
                                                                    -------------       -------------       -------------
Cash flows from investing activities:
Capital expenditures ..........................................        (1,240,775)           (788,661)         (1,782,090)
Proceeds from sales and maturities of marketable
 securities available for sale ................................        47,470,593           8,559,604           2,495,992
Purchases of marketable securities available for sale .........       (30,584,284)        (10,616,494)         (4,802,227)
Proceeds from sale of chiral assets ...........................                --           7,500,000                  --
Purchase of license rights ....................................                --                  --            (450,000)
                                                                    -------------       -------------       -------------
Net cash provided by (used in) investing activities ...........        15,645,534           4,654,449          (4,538,325)
                                                                    -------------       -------------       -------------
Cash flows from financing activities:
Net proceeds from secondary offering ..........................        18,206,130                  --                  --
Costs related to secondary offering ...........................                --             (73,136)                 --
Proceeds from sale of stock ...................................                --           2,500,000                  --
Proceeds from exercise of common stock options and
 warrants .....................................................            20,217           3,019,612           8,399,624
Redemption of Series A preferred stock ........................          (721,287)                 --                  --
Net proceeds from issuance of preferred stock .................         4,840,748                  --                  --
Capital lease buyout ..........................................                --            (400,414)           (218,141)
Capital lease funding .........................................           561,169             260,195                  --
Debt issuance costs ...........................................                --                  --            (750,000)
Net proceeds from issuance of convertible notes ...............                --           8,348,959          30,000,000
                                                                    -------------       -------------       -------------
Net cash provided by financing activities .....................        22,906,977          13,655,216          37,431,483
                                                                    -------------       -------------       -------------
Net increase (decrease) in cash and cash equivalents ..........        12,660,484         (10,516,492)         12,188,469
Cash and cash equivalents at beginning of year ................           922,961          13,583,445           3,066,953
                                                                    -------------       -------------       -------------
Cash and cash equivalents at end of year ......................     $  13,583,445       $   3,066,953       $  15,255,422
                                                                    =============       =============       =============
</TABLE>

                                      F-6
<PAGE>


<TABLE>
<CAPTION>
                                                                         YEARS ENDED DECEMBER 31,
                                                             -------------------------------------------------
                                                                   1997             1998             1999
                                                             ---------------   --------------   --------------
<S>                                                          <C>               <C>              <C>
Non-cash investing activity:
Change in net unrealized gain(loss) on marketable
 securities available for sale ...........................     $    (5,714)     $        --       $  (91,904)
                                                               ===========      ===========       ==========
Issuance of options related to license agreement .........     $        --      $        --       $  696,895
                                                               ===========      ===========       ==========
Non-cash financing activities:
Issuance of common stock upon the conversion of
 convertible debentures and accrued interest thereon,
 net .....................................................     $ 2,331,304      $        --       $       --
                                                               ===========      ===========       ==========
Accretion of premium payable on preferred stock and
 warrants ................................................     $   521,397      $    24,648       $       --
                                                               ===========      ===========       ==========
Deemed dividend for preferred stock conversion discount        $   953,077      $        --       $       --
                                                               ===========      ===========       ==========
Issuance of common stock upon the conversion of
 convertible preferred stock and accrued accretion
 thereon, net ............................................     $14,654,071      $ 4,054,103       $       --
                                                               ===========      ===========       ==========
Supplemental disclosure of cash flow information:
Interest paid ............................................     $    20,599      $    19,766       $1,504,441
                                                               ===========      ===========       ==========
Cash received related to tax benefit .....................     $        --      $        --       $3,017,910
                                                               ===========      ===========       ==========
</TABLE>

See accompanying notes to consolidated financial statements.

                                      F-7
<PAGE>

                               CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                        DECEMBER 31, 1997, 1998, AND 1999


(1)  NATURE OF BUSINESS AND LIQUIDITY

     Celgene  Corporation  and  its  subsidiary  (collectively  "Celgene" or the
"Company")   is   an   independent  biopharmaceutical  company  engaged  in  the
discovery,  development and commercialization of novel human pharmaceuticals for
the  treatment  of  cancer  and  immunological  diseases.  The Company's primary
therapeutic  focus  is on the development of orally administered, small molecule
pharmaceuticals  that  regulate  tumor  necrosis factor alpha, or TNF--, and are
anti-angiogenic.  TNF--  has  been  linked  to  the  cause  and symptoms of many
chronic  inflammatory  and immunological diseases. Anti-angiogenic drugs inhibit
the  growth  of  undesirable  blood  vessels, including those that promote tumor
growth.  Our  lead product, THALOMID(TM) (thalidomide), was approved for sale in
the  United  States  by  the U.S. Food and Drug Administration, ("FDA"), on July
16,  1998.  THALOMID is approved for the treatment of erythema nodosum leprosum,
("ENL"),  an  inflammatory  complication  of  leprosy. Our cancer and immunology
pharmaceutical  pipeline  is highlighted by two classes of novel and proprietary
oral  therapeutic  agents,  IMiDs,  or  ImmunoModulatory  Drugs, and SelCIDs, or
Selective  Cytokine  Inhibitory  Drugs. Both classes are being developed for the
treatment  of  cancer, chronic inflammatory diseases, such as inflammatory bowel
disease and rheumatoid arthritis, and other diseases of the immune system.

     The  Company  expects that its rate of spending will increase as the result
of  increased  clinical  trial  costs,  increased  expenses  associated with the
regulatory   approval   process   and   commercialization  of  products  now  in
development,  increased  costs related to the commercialization of THALOMID, and
increased   working  capital  requirements.  This  increased  spending  will  be
mitigated  by the collection of receivables resulting from sales of THALOMID. It
is  anticipated  that the increasing sales of THALOMID, as well as existing cash
resources, will be sufficient to fund operations through 2000.

     The  consolidated  financial  statements include the parent Company and its
subsidiary  Celgro.  All  inter-company  transactions  have been eliminated. The
preparation  of  the  consolidated  financial  statements requires management to
make  estimates  and  assumptions  that affect reported amounts and disclosures.
Actual  results  could  differ  from  those estimates. The Company is subject to
certain  risks  and  uncertainties  such  as uncertainty of product development,
uncertainties  regarding  regulatory approval, no assurance of market acceptance
of   products,  risk  of  product  liability,  uncertain  scope  of  patent  and
proprietary rights, intense competition, and rapid technological change.

(2)  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

     (A) CASH EQUIVALENTS

     At  December  31,  1998 and 1999, cash equivalents consisted principally of
funds  invested  in  money market funds, and United States government securities
such as treasury bills and notes.

     (B) MARKETABLE SECURITIES

     The  Company  classifies  all  of  its  marketable securities as securities
available  for  sale.  Such securities are held for an indefinite period of time
and  were  intended  to  be  used  to  meet  the  ongoing liquidity needs of the
Company.  Realized  gains and losses are included in operations and are measured
using the specific cost identification method.

     (C) INVENTORY

     Inventories  are  priced  at  lower  of  cost or market using the first-in,
first-out  (FIFO)  method.  Prior to FDA approval, the raw material, formulation
and  encapsulation  costs  related  to  THALOMID  production  were  recorded  as
research and development expense.


                                      F-8
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

     (D) LONG-LIVED ASSETS

     Plant  and  equipment  are  stated  at  cost.  Depreciation  of  plant  and
equipment  is  provided  using  the  straight-line  method. The estimated useful
lives of fixed assets are as follows:


<TABLE>
<S>                                                  <C>
        Laboratory equipment and machinery ......... 5-10 years
        Furniture and fixtures ..................... 5-10 years

</TABLE>

     Amortization   of   leasehold   improvements   is   calculated   using  the
straight-line  method  over  the  term  of  the  lease or the life of the asset,
whichever  is  shorter.  Maintenance  and  repairs  are charged to operations as
incurred, while renewals and improvements are capitalized.

     The  Company  reviews  long-lived  assets for impairment whenever events or
changes  in  business circumstances occur that indicate that the carrying amount
of  the  assets  may not be recoverable. The Company assesses the recoverability
of  long-lived  assets  held and to be used based on undiscounted cash flows and
measures the impairment, if any, using discounted cash flows.

     (E) RESEARCH AND DEVELOPMENT COSTS

     All research and development costs are expensed as incurred.

     (F) INCOME TAXES

     The  Company  utilizes  the  asset  and  liability method of accounting for
income  taxes.  Under  this  method,  deferred  tax  assets  and liabilities are
determined  based  on  the  difference  between the financial statement carrying
amounts  and  tax  bases  of  assets  and liabilities using enacted tax rates in
effect for years in which the temporary differences are expected to reverse.

     Research  and  development tax credits will be recognized as a reduction of
the provision for income taxes when realized.

     (G) REVENUE RECOGNITION

     Revenue  from  the  sale  of  products is recognized upon product shipment.
Revenue  under  research  contracts  is  recorded as earned under the contracts,
generally  as  services  are  provided.  Revenue  is  recognized immediately for
nonrefundable   license   fees   when  agreement  terms  require  no  additional
performance on the part of the Company.

     (H) STOCK OPTION PLAN

     The   Company  applies  the  intrinsic  value-based  method  of  accounting
prescribed  by  Accounting  Principles  Board ("APB") Opinion No. 25, Accounting
for  Stock  Issued  to Employees, and related interpretations, in accounting for
its  fixed  plan  stock options. As such, compensation expense would be recorded
on  the  date  of grant only if the current market price of the underlying stock
exceeded   the  exercise  price.  Statement  of  Financial  Accounting  Standard
("SFAS")   No.   123,   Accounting  for  Stock-Based  Compensation,  established
accounting  and  disclosure  requirements  using  a  fair  value-based method of
accounting  for  stock-based employee compensation plans. As allowed by SFAS No.
123,  the  Company  has  elected  to continue to apply the intrinsic value-based
method   of   accounting   described  above,  and  has  adopted  the  disclosure
requirements of SFAS No. 123.

     (I) EARNINGS PER SHARE

     "Basic"  earnings  per  common  share equals net income divided by weighted
average  common  shares  outstanding  during  the period. "Diluted" earnings per
common  share  equals  net  income divided by the sum of weighted average common
shares  outstanding during the period plus common stock equivalents if dilutive.
The  Company's  basic  and  diluted  per  share  amounts  are the same since the
assumed exercise


                                      F-9
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

of  stock  options,  and  warrants, and the conversion of convertible debentures
and   preferred  stock  are  all  anti-dilutive.  The  amount  of  common  stock
equivalents  excluded  from the calculation were 3,770,954 in 1997, 3,863,535 in
1998 and 5,296,624 in 1999.

     (J) COMPREHENSIVE INCOME

     Comprehensive  income  (loss)  consists of net losses and the change in net
unrealized  gains  (losses)  on  securities and is presented in the consolidated
statements of stockholders' equity (deficit).

     (K) PRESENTATION

     In  connection  with  the  disposition of the Company's chiral intermediate
operation  in  January  1998  (see note 10), the 1997 and 1998 financial results
applicable  to  continuing  operations  exclude  amounts  from this discontinued
operation.

     (L) FAIR VALUE OF FINANCIAL INSTRUMENTS

     The  fair  value,  which  equals  carrying  value, of marketable securities
available  for  sale  is  based on quoted market prices. For all other financial
instruments,  excluding  convertible  notes  (see  note 6), their carrying value
approximates fair value due to the short maturity of these instruments.

     In  June  1998,  SFAS  No.  133,  Accounting for Derivative Instruments and
Hedging  Activities  was  issued  and,  as  amended, is effective for all fiscal
years  beginning  after  June 15, 2000. SFAS No. 133 standardizes the accounting
for  derivative instruments including certain derivative instruments embedded in
other  contracts  and requires derivative instruments to be recognized as assets
and  liabilities  and  be  recorded  at fair value. The Company is currently not
party   to   any  derivative  instruments.  Any  future  transactions  involving
derivative instruments will be evaluated based on SFAS No. 133.

     (M) OTHER ASSETS

     Other  assets include certain patent rights, the cost of which is amortized
using  the  straight  line  method  over  the  life of the patents. The weighted
average remaining patent life at December 31, 1999 is 12 years.

(3) INVENTORY


<TABLE>
<CAPTION>
                                          DECEMBER 31,
                                 -------------------------------
                                      1998             1999
                                 --------------   --------------
<S>                              <C>              <C>
     Raw materials ...........    $   440,400      $ 1,411,663
     Work in process .........        535,494          647,841
     Finished goods ..........        595,514          396,555
                                  -----------      -----------
                                  $ 1,571,408      $ 2,456,059
                                  ===========      ===========

</TABLE>

     Inventory  costs  prior  to  FDA approval of THALOMID on July 16, 1998 were
expensed as research and development costs.


                                      F-10
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

(4) PLANT AND EQUIPMENT

     Plant and equipment consists of the following:


<TABLE>
<CAPTION>
                                                             DECEMBER 31,
                                                    -------------------------------
                                                         1998             1999
                                                    --------------   --------------
<S>                                                 <C>              <C>
     Leasehold improvements .....................    $ 4,008,246      $ 4,375,013
     Laboratory equipment and machinery .........      4,874,733        5,323,897
     Furniture and fixtures .....................        470,667          605,623
     Leased equipment ...........................        675,304          675,304
                                                     -----------      -----------
                                                      10,028,950       10,979,837
     Less: accumulated depreciation .............      7,766,820        8,643,595
                                                     -----------      -----------
                                                     $ 2,262,130      $ 2,336,242
                                                     ===========      ===========

</TABLE>

(5) ACCRUED EXPENSES

     Accrued expenses consists of the following:


<TABLE>
<CAPTION>
                                                           DECEMBER 31,
                                                  -------------------------------
                                                       1998             1999
                                                  --------------   --------------
<S>                                               <C>              <C>
     Professional and consulting fees .........    $   787,381      $   905,072
     Accrued compensation .....................      1,650,048        3,098,540
     Accrued interest and royalties ...........        361,809        1,989,394
     Other ....................................        242,621          768,883
                                                   -----------      -----------
                                                   $ 3,041,859      $ 6,761,889
                                                   ===========      ===========

</TABLE>

(6)  CONVERTIBLE DEBT

     On  September  16,  1998,  the  Company  issued  a  convertible  note to an
institutional  investor  in  the  amount of $8,750,000. The note has a five year
term  and  a  coupon rate of 9.25% with interest payable on a semi-annual basis.
The  note  contains  a conversion feature that allows the note holder to convert
the  note  into  common shares at $11 per share. The Company can redeem the note
after  three  years  at 103% of the principal amount (two years if the Company's
stock  trades  at $24.75 or higher for a period of 20 consecutive trading days).
This  note  was  issued  at a discount of $437,500 which is being amortized over
three years.

     On  January  20,  1999,  the  Company issued to an institutional investor a
convertible  note  in  the  amount of $15,000,000. The note has a five year term
and  a  coupon rate of 9% with interest payable on a semi-annual basis. The note
contains  a  conversion  feature that allows the note holder to convert the note
into  common  shares after one year at $18 per share. The Company can redeem the
note  after three years at 103% of the principal amount (two years under certain
conditions).  Issuance  costs  of $750,000 incurred in connection with this note
are being amortized over three years.

     On  July  6,  1999,  the Company issued to a third institutional investor a
convertible  note  in  the  amount of $15,000,000. The note has a five year term
and  a  coupon rate of 9% with interest payable on a semi-annual basis. The note
contains  a  conversion  feature that allows the note holder to convert the note
into  common  shares after one year at $19 per share. The Company can redeem the
note  after three years at 103% of the principal amount (two years under certain
conditions). There was no fee or discount associated with this note.


                                      F-11
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

     At  December  31,  1999,  the fair value of the Company's convertible notes
exceeded  their  carrying value, reflecting the increase to $70 per share in the
market value of the Company's common stock at that date.


(7)  STOCKHOLDERS' EQUITY

     PREFERRED STOCK

     The  Board  of  Directors  has the authority to issue, at any time, without
further  stockholder approval, up to 5,000,000 shares of preferred stock, and to
determine the price, rights, privileges, and preferences of those shares.

     SERIES A CONVERTIBLE PREFERRED STOCK

     During  1996, in a private placement, the Company completed the sale of 503
shares  of Series A Convertible Preferred Stock, par value $.01 per share, at an
issue  price of $50,000 per share. All of the shares of the Series A Convertible
Preferred  Stock  with their respective accrued accretion, had been converted or
redeemed into 3,342,202 shares of common stock at December 31, 1998.

     During  1996,  the  Company  had  issued  warrants valued at $138,156, that
entitle  certain  stockholders  of  the  Series A Convertible Preferred Stock to
purchase  153,507  shares  of  common  stock at an exercise price of $11.50. The
warrants  were  issued  in  exchange for the deferral of conversion for 90 days.
All  these  warrants either expired or were exercised for 3,418 shares of common
stock  at  December  31,  1998.  In  connection  with the private placement, the
Company  also  granted  to  certain  executives  and affiliates of the placement
agent  warrants, valued at $60,168, to purchase an aggregate of 66,853 shares of
common  stock at an exercise price of $20.52, subject to proportional adjustment
in  the  event  that  the  Company  undertakes  a  stock  split, stock dividend,
recapitalization  or  similar event. These warrants are exercisable for a period
of  five  years  from  the  date  of  issuance.  As of December 31, 1999, 35,039
warrants were exercised to purchase 23,322 shares of common stock.

     SERIES B CONVERTIBLE PREFERRED STOCK

     During  1997,  in  a  private  placement, the Company completed the sale of
5,000   shares   of   Series  B  Convertible  Preferred  Stock  (the  "Series  B
Preferred"),  par  value  $.01 per share, at an issue price of $1,000 per share.
The  Company  received  net proceeds, after offering costs of $4,840,748. Shares
could  be  converted  at  an  initial  conversion  price of $6.50 per share. All
shares  of  the  Series  B  Preferred  had been converted into 788,469 shares of
common stock at December 31, 1998.

     Upon  request  of  the purchasers of the Series B Preferred, the Company is
required  to  issue warrants to acquire a number of shares of common stock equal
to  (i) 1,500,000 divided by the Conversion Price in effect on the Issuance Date
(230,769  warrants  as  of  December 31, 1999) plus (ii) 37.5% of the conversion
shares  issuable on such issuance date upon conversion of all shares of Series B
Preferred  issued through the issuance date (288,461 warrants as of December 31,
1999).  All  such warrants will have a term of four years from the issuance date
and  an  exercise  price  equal to 115% of the conversion price in effect on the
issuance  date  ($6.50  at December 31, 1999). The fair value of warrants at the
issuance  date  was  $1.28 per warrant. As of December 31, 1999 no warrants have
been exercised.

     RIGHTS PLAN

     During  1996,  the  Company  adopted  a  shareholder  rights  plan ("Rights
Plan").  The  Rights Plan involves the distribution of one "Right" as a dividend
on  each  outstanding  share  of  the  Company's  common stock to each holder of
record  on  September  26, 1996. Each Right shall entitle the holder to purchase
one-tenth  of  a  share  of  common  stock.  The Rights trade in tandem with the
common  stock  until,  and  are exercisable upon, certain triggering events, and
the  exercise  price  is based on the estimated long term value of the Company's
common stock. In certain circumstances, the Rights Plan permits the


                                      F-12
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

holders  to  purchase shares of the Company's common stock at a discounted rate.
The  Company's  Board  of  Directors  retains  the  right  at all times prior to
acquisition  of  15%  of  our voting common stock by an acquiror, to discontinue
the  Rights  Plan  through  the  redemption of all rights or to amend the Rights
Plan in any respect.


(8)  STOCK BASED COMPENSATION


     (A) STOCK OPTIONS

     The  Company  has  two  Incentive  Plans  that  provide for the granting of
options,  restricted stock awards, stock appreciation rights, performance awards
and  other  stock-based  awards  to  employees  and  officers  of the Company to
purchase  not  more  than an aggregate of 1,400,000 shares of common stock under
the  1992 plan and 1,500,000 shares of common stock under the 1998 plan, subject
to  adjustment  under  certain  circumstances.  The  Management Compensation and
Development  Committee  of  the  Board of Directors (the "Committee") determines
the  type,  amount  and  terms,  including vesting, of any awards made under the
Incentive Plans. The Plans terminate in 2002 and 2008, respectively.

     With  respect  to  options  granted under the Incentive Plans, the exercise
price  may  not  be  less  than the fair market value of the common stock on the
date  of  grant.  In  general,  each option granted under the Plans vests evenly
over  a  three  or four year period and expires 10 years from the date of grant,
subject  to earlier expiration in case of termination of employment. The vesting
period  for  options  and  restricted  stock  awards  granted under the Plans is
subject  to  certain  acceleration provisions if a change in control, as defined
in the Plans, occurs.

     On  June  16,  1995,  the  stockholders  of  the  Company approved the 1995
Non-Employee  Directors'  Incentive  Plan,  which  provides  for the granting of
non-qualified  stock  options  to purchase an aggregate of not more than 350,000
shares  of  common  stock (subject to adjustment under certain circumstances) to
directors  of  the  Company  who  are  not  officers or employees of the Company
("Non-Employee  Directors").  Each  new  Non-Employee Director, upon the date of
election  or appointment, receives an option to purchase 20,000 shares of common
stock.  Additionally, upon the date of each annual meeting of stockholders, each
continuing  Non-Employee  Director  receives an option to purchase 10,000 shares
of  common stock (or a pro rata portion thereof for service less than one year).
The  shares  subject  to  each  non-employee  director's  option grant of 20,000
shares   vest  in  four  equal  annual  installments  commencing  on  the  first
anniversary  of  the  date  of  grant.  The  shares subject to an annual meeting
option  grant  vest  in  full  on  the  date  of  the  first  annual  meeting of
stockholders   held  following  the  date  of  grant.  On  June  22,  1999,  the
stockholders  of  the  Company  approved  an  amendment to the 1995 Non-Employee
Directors'  Incentive  Plan  that  a.) increased the number of shares to 600,000
and  b.) provided for a discretionary grant upon the date of each annual meeting
of  an  additional  option  to  purchase  up  to  5,000 shares to a non-employee
director  who  serves  as  a  member  (but not a chairman) of a committee of the
Board  of  Directors  and  up  to  10,000  shares to a non-employee director who
serves  as  the  chairman  of a committee of the Board of Directors. All options
are  granted  at  an  exercise  price  that  equals the fair market value of the
Company's  common  stock at the grant date and expire 10 years after the date of
grant. This plan terminates in 2005.


                                      F-13
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

     The  weighted-average  fair  value  per share for stock options granted was
$9.26  for  the  1999  options,  $3.97  for the 1998 options and $3.93 for those
granted  in  1997. The Company estimated the fair values using the Black-Scholes
option pricing model and used the following assumptions:


<TABLE>
<CAPTION>
                                                            1997         1998         1999
                                                         ----------   ----------   ----------
<S>                                                      <C>          <C>          <C>
       Risk-free interest rate .......................       6.37%        5.68%        6.38%
       Expected stock price volatility ...............         55%          66%          46%
       Expected term until exercise (years) ..........       3.09         2.86         4.98
       Expected dividend yield .......................          0%           0%           0%
</TABLE>

     The  Company  does not record compensation expense for stock option grants.
The  following  table summarizes results as if compensation expense was recorded
for the annual option grants under the fair value method:





<TABLE>
<CAPTION>
                     (THOUSANDS OF DOLLARS,
                     EXCEPT PER SHARE DATA)                          1997           1998           1999
- --------------------------------------------------------------- -------------- -------------- --------------
<S>                                                             <C>            <C>            <C>
     Net loss applicable to common stockholders:
      As reported .............................................   $  (26,922)    $  (25,093)    $  (21,781)
      Pro forma ...............................................      (28,652)       (26,745)       (25,491)
     Net loss per share applicable to common stockholders basic
      and diluted:
      As reported .............................................        (2.20)         (1.55)         (1.28)
      Pro forma ...............................................        (2.35)         (1.66)         (1.50)

</TABLE>

     The  pro  forma  effects  on net loss applicable to common stockholders and
net  loss  per  share  applicable to common stockholders (basic and diluted) for
1997,  1998  and  1999  may  not  be  representative of the pro forma effects in
future  years since compensation cost is allocated on a straight-line basis over
the vesting periods of the grants, which extends beyond the reported years.


                                      F-14
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

     The  following   table   summarizes  the  stock  option  activity  for  the
aforementioned Plans:





<TABLE>
<CAPTION>
                                                        OPTIONS OUTSTANDING
                                        SHARES    -------------------------------
                                      AVAILABLE                  WEIGHTED AVERAGE
                                      FOR GRANT       SHARES     PRICE PER SHARE
                                    ------------- ------------- -----------------
<S>                                 <C>           <C>           <C>
Balance January 1, 1997 ...........     442,845     2,006,214       $   9.60
 Authorized .......................     500,000            --             --
 Expired ..........................     (74,797)           --             --
 Granted ..........................    (492,775)      492,775           9.39
 Exercised ........................          --        (6,986)          7.83
 Cancelled ........................     142,027      (142,027)          9.36
                                       --------     ---------       --------
Balance December 31, 1997 .........     517,300     2,349,976           9.59
 Authorized .......................   1,620,000            --             --
 Expired ..........................     (85,095)           --             --
 Granted ..........................    (559,983)      559,983           8.87
 Exercised ........................          --      (283,120)          7.18
 Cancelled ........................     198,726      (198,726)         10.74
                                      ---------     ---------       --------
Balance December 31, 1998 .........   1,690,948     2,428,113           9.62
 Authorized .......................     250,000            --             --
 Expired ..........................     (70,047)           --             --
 Granted ..........................    (890,530)      890,530          19.26
 Exercised ........................          --      (949,323)          8.46
 Cancelled ........................      42,053       (42,053)         10.66
                                      ---------     ---------       --------
Balance December 31, 1999 .........   1,022,424     2,327,267       $  13.76
                                      =========     =========       ========
</TABLE>

     The  following  table summarizes information concerning options outstanding
under the Plans at December 31, 1999:


<TABLE>
<CAPTION>
                                    WEIGHTED       WEIGHTED                       WEIGHTED
                       NUMBER        AVERAGE       AVERAGE          NUMBER        AVERAGE
    RANGE OF        OUTSTANDING     EXERCISE      REMAINING      EXERCISABLE      EXERCISE
 EXERCISE PRICE     AT 12/31/99       PRICE      TERM (YRS.)     AT 12/31/99       PRICE
- ----------------   -------------   ----------   -------------   -------------   -----------
<S>                <C>             <C>          <C>             <C>             <C>
5.00 -- 9.00           627,518     $   7.78           6.8          322,966       $   7.25
9.01 --13.00           450,920        10.69           6.9          294,861          10.69
13.01--18.00         1,137,329        15.93           8.2          349,407          14.43
18.01 +                111,500        37.74           9.8               --             --
                     ---------     --------           ---          -------       --------
                     2,327,267     $  13.76           7.6          967,234       $  10.89
                     =========     ========           ===          =======       ========
</TABLE>

     (B) STOCK AWARDS

     On  January  1,  1997,  the  Company  awarded 5,000 shares to the Company's
Chairman  and  Chief  Executive Officer, which were immediately vested. The fair
value of $55,625 for this award was expensed.

     (C) WARRANTS

     In  connection  with  the  retention of an investment firm to assist in the
sale  and  issuance of the Series A Convertible Preferred Stock, the Company, in
1996  granted  to  such  firm, warrants to purchase until March 10, 2001, 66,853
shares  of  common  stock  at  a  price  of  $20.52.  There were 31,814 warrants
outstanding as of December 31, 1999.


                                      F-15
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

     In  connection  with  the  placement  of the Series B Convertible Preferred
Stock  in  June,  1997,  the  Company  has  an  obligation  to issue warrants to
purchase  519,230 shares of common stock until June 1, 2002, at a price of $7.48
per share. As of December 31, 1999 these warrants were outstanding.

(9) INCOME TAXES

     At  December  31,  1998  and 1999, the tax effects of temporary differences
that give rise to deferred tax assets are as follows:



<TABLE>
<CAPTION>
                                                                                 1998            1999
                                                                           --------------- ---------------
<S>                                                                        <C>             <C>
Deferred assets:
 Federal and state net operating loss carryforwards ......................  $  54,779,000   $  73,147,000
 Research and experimentation tax credit carryforwards ...................      3,235,000       3,984,000
 Plant and equipment, principally due to differences in depreciation .....        772,000       1,075,000
 Patents, principally due to differences in amortization .................         62,000          58,000
 Accrued expenses ........................................................        665,000         560,000
                                                                            -------------   -------------
    Total deferred tax assets ............................................     59,513,000      78,824,000
 Valuation allowance .....................................................    (59,513,000)    (78,824,000)
                                                                            -------------   -------------
    Net deferred tax assets ..............................................  $          --   $          --
                                                                            =============   =============

</TABLE>

     A  valuation  allowance  is  provided  when it is more likely than not that
some  portion  or  all  of  the  deferred  tax  assets  will not be realized. At
December  31,  1999, the Company had Federal net operating loss carryforwards of
approximately  $184,000,000  and  state  net  operating  loss  carryforwards  of
approximately  $121,000,000  that  will  expire  in the years 2001 through 2019.
State  net  operating  loss carryforwards differ from Federal net operating loss
carryforwards  primarily  due  to  the  fact that the Company sold approximately
$39,000,000  of  its  state  net  operating  loss  carryforwards during 1999 and
approximately  $24,000,000  has  expired.  The  Company  also  has  research and
experimentation  credit carryforwards of approximately $3,984,000 that expire in
the  years  2001  through  2019.  Ultimate  utilization/availability of such net
operating  losses  and  credits  may  be  curtailed  if  a significant change in
ownership  occurs.  Of  the  deferred tax asset related to the Federal and state
net  operating  loss  carryforwards,  approximately $12,500,000 relates to a tax
deduction  for  non  qualified  stock options. The Company will increase paid in
capital when these benefits are realized for tax purposes.

(10) DISCONTINUED OPERATION

     On  January  9,  1998,  the  Company  concluded  an  agreement with Cambrex
Corporation  ("Cambrex")  for  Cambrex  to acquire Celgene's chiral intermediate
business  for  approximately $15 million. The Company received $7.5 million upon
the  closing  of  the  transaction,  and  will  receive  future royalties with a
present  value not exceeding $7.5 million, with certain minimum royalty payments
in  the  third  through  sixth  year  following  the closing of the transaction.
Included  in  the  transaction  are the rights to Celgene's enzymatic technology
for  the  production  of  chirally  pure  intermediates  for  the pharmaceutical
industry,  including  the  current  pipeline  of  third  party  products and the
equipment and personnel associated with the business.

(11) MARKETABLE SECURITIES AVAILABLE FOR SALE

     Marketable  securities available for sale at December 31, 1999 include debt
securities  with  maturities ranging from January 2000 to August 2004. A summary
of marketable securities at December 31, 1999 is as follows:


                                      F-16
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )


<TABLE>
<CAPTION>
                                                     GROSS        GROSS      ESTIMATED
                                                  UNREALIZED   UNREALIZED       FAIR
                                        COST         GAIN         LOSS         VALUE
                                   ------------- ------------ ------------ -------------
<S>                                <C>           <C>          <C>          <C>
Government Bonds & Notes .........  $2,313,125       --        $ (25,579)   $2,287,546
Government Agencies ..............   2,050,000       --          (66,325)    1,983,675
                                    ----------       --        ---------    ----------
 Total ...........................  $4,363,125       --        $ (91,904)   $4,271,221
                                    ==========       ==        =========    ==========

</TABLE>

     Marketable  securities available for sale at December 31, 1998 include debt
securities   with   maturities  ranging  from  March,  1999  to  October,  2002.
Marketable  securities at December 31, 1998 include Corporate Bonds ($1,006,890)
and  U.S.  Government and agency obligations ($1,050,000). The cost equaled fair
market value.


(12) COMMITMENTS AND CONTINGENCIES

     (A) LEASES

     Celgene  leases  its  main  laboratory  and  office  facilities  in  Warren
Township,  New Jersey. The current lease term for the main laboratory and office
space  expires in 2002 and has one five-year renewal option. Annual payments are
$330,000.  The  lease  provides that at the end of each five-year term, the rent
will  be  increased based upon the change in the consumer price index, but in no
case  shall  the  increase  be greater than 20%. Celgene is also required to pay
additional  amounts  for  real  estate  taxes, utilities, and maintenance. Total
rental  expense  amounted  to  $477,000, $486,000 and $479,000 in 1997, 1998 and
1999,  respectively.  Celgene  has subleased 12,500 square feet of this facility
to  Cambrex  Corporation  for  up  to  three  years  for the Chiral Intermediate
business which Cambrex purchased on January 9, 1998.

     In  November,  1999, the Company leased an additional 29,000 square feet of
office  and laboratory space in the same building facility in Warren, New Jersey
adjacent  to our existing leased space. The initial term of the lease extends to
July 2010 with two five year renewal options.

     In  March  1999,  the  Company  entered into a lease agreement with The New
Jersey  Economic  Development  Authority  (NJEDA)  to lease approximately 18,000
square  feet  of  office and laboratory space in North Brunswick, New Jersey for
Celgro,  our  agrochemical  subsidiary.  The  lease  agreement  is for ten years
commencing January 1, 2000 and provides for two five year renewal terms.

     In  July,  1997,  the  Company entered into an equipment leasing agreement;
under  the  agreement, the Company can lease up to $1,000,000 of equipment for a
three  year  term  after  which  the  Company  can  purchase the equipment for a
nominal  value.  Through  December  31, 1999, the Company has leased $675,000 of
laboratory equipment under this agreement.

     The  following  table  shows  the approximate minimum lease commitments for
the next five years:


<TABLE>
<CAPTION>
     2000            2001            2002            2003            2004         AFTER 2004
- -------------   -------------   -------------   -------------   -------------   -------------
<S>             <C>             <C>             <C>             <C>             <C>
$1,257,000       $1,106,000      $1,086,000      $1,122,000      $1,131,000      $4,903,000
</TABLE>

     (B) EMPLOYMENT AGREEMENTS

     Celgene  has employment agreements with certain officers and employees. The
related   outstanding   commitment  for  2000  is  approximately  $1.3  million.
Employment  contracts  provide for an increase in compensation reflecting annual
reviews and related salary adjustments.


                                      F-17
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

     (C) CONTRACTS

     Pursuant  to  the  terms  of  a research and development agreement with The
Rockefeller  University  ("Rockefeller"), the Company has purchased for cash and
stock  options  the  world-wide  exclusive license to manufacture and market any
drugs,  including  THALOMID,  which  may  result  from the research performed at
Rockefeller  and  funded  by  the  Company.  The  portion  of the agreement that
provides  for  research services to be performed by Rockefeller is renewable for
one  year  terms  upon  agreement  of  both  parties. Under terms of the current
research  agreement  extension,  the  Company  is  committed  to pay Rockefeller
$504,000 annually for research.

     The  Company  has  an  agreement  with  Penn  Pharmaceutical, Ltd. of Great
Britain  ("Penn") for the production of THALOMID. Penn manufactures THALOMID and
sells  it  exclusively  to  the Company. The agreement is renewable for one year
terms   and   has   been  renewed  for  2000,  for  facility  payments  totaling
approximately $480,000.

     In   October  1997,  the  Company  entered  into  a  contract  with  Boston
University  to  manage  the  surveillance  registry which is intended to monitor
compliance  to the requirements of the Company's S.T.E.P.S. (System for THALOMID
Education  and  Prescribing  Safety)  program  for  all  THALOMID  patients. The
contract  has been renewed for 2000. Under the terms of the agreement, quarterly
payments  of  approximately $395,000 are required. The contract is renewable for
one year terms upon agreement of both parties.

     In  December  1997,  the Company entered into a research agreement with the
University  of  Glasgow  for  clinical  testing  and  evaluation  of  certain of
Celgene's  patented  compounds. Under terms of the agreement, the Company agreed
to  pay  the  University  approximately $200,000 in two annual installments. The
term  of  the original agreement was for two years and has been extended through
2000.

     In  June  1998,  the  Company  entered  into  a  research  agreement with a
contract  research  organization  to  manage  the  pivotal  clinical  trial  for
d-methylphenidate  encompassing  four  separate  protocols. The agreement is for
approximately  two years and is estimated at approximately $5.0 million over the
life of the agreement.

     In  December  1998, the Company entered into an exclusive license agreement
with  EntreMed,  Inc.  ("EntreMed")  whereby EntreMed granted to us an exclusive
license  to  its  patent  and  technology  rights  for  thalidomide.  In return,
EntreMed will receive royalties on all sales of THALOMID.

     (D) CONTINGENCIES

     The  Company  believes  it  maintains  insurance  coverage adequate for its
current needs.

     The  Company's operations are subject to environmental laws and regulations
which  impose  limitations on the discharge of pollutants into the air and water
and  establish  standards  for  the treatment, storage and disposal of solid and
hazardous  wastes.  The Company reviews the effects of such laws and regulations
on  its  operation  and  modifies  its  operations  as  appropriate. The Company
believes  that it is in substantial compliance with all applicable environmental
laws and regulations.

(13) SEGMENTS

     Effective  January  1,  1998, the Company adopted SFAS No. 131, Disclosures
about  Segments  of  an Enterprise and Related Information. As discussed in Note
1,  the  Company  manages  its  operations as one line of business of discovery,
development  and  commercialization of orally administered, small molecule drugs
for  the  treatment  of  cancer  and  immunological  diseases. Additionally, our
chiral  chemistry  program develops chirally pure versions of existing compounds
for  both pharmaceutical and agrochemical markets. The Company markets and sells
its  products  in  the  United States. During 1999, no single customer accounted
for more than 3% of the Company's product sales.


                                      F-18
<PAGE>

                              CELGENE CORPORATION
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                DECEMBER 31, 1997, 1998, AND 1999 - (CONTINUED )

(14) SUBSEQUENT EVENT

     On  February  16, 2000, the Company completed an offering to sell 3,450,000
shares  of  its common stock at a price of $101 per share. 2,934,000 shares were
for  the  account  of  the  Company and 516,000 shares were for the account of a
selling  shareholder pursuant to the conversion of $9,288,000 of the 9%, January
1999  convertible  notes  held by that shareholder. Proceeds to the Company, net
of expenses, were approximately $278 million.


                                      F-19
<PAGE>

                 SCHEDULE II-VALUATION AND QUALIFYING ACCOUNTS
                              CELGENE CORPORATION





<TABLE>
<CAPTION>
                                                BALANCE AT       ADDITIONS                    BALANCE AT
                                               BEGINNING OF     CHARGED TO                      END OF
                                                   YEAR           EXPENSE      DEDUCTIONS        YEAR
                                              --------------   ------------   ------------   -----------
<S>                                           <C>              <C>            <C>            <C>
Year ended December 31, 1998
 Allowance for doubtful accounts ..........           --           43,386             --        43,386
                                                      --           ------             --        ------
                                                      --           43,386             --        43,386
Year ended December 31, 1999
 Allowance for doubtful accounts ..........       43,386           58,051             --       101,437
 Allowance for customer discounts .........           --          453,208        433,208        20,000
                                                  ------          -------        -------       -------
                                                  43,386          511,259        433,208       121,437
                                                  ======          =======        =======       =======

</TABLE>





                                                                   EXHIBIT 10.10

                    AMENDED AND RESTATED EMPLOYMENT AGREEMENT

     THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this "Agreement"), dated as
of January 1, 2000,  between Celgene  Corporation,  a Delaware  corporation with
offices at 7 Powder Horn Drive,  Warren,  New Jersey 07059 (the "Company"),  and
John  W.  Jackson,  residing  at 32  Gregory  Lane,  Warren,  New  Jersey  07059
("Employee").

                               W I T N E S S E T H
                               - - - - - - - - - -

     WHEREAS,   the  Company  and  Employee  have  previously  entered  into  an
employment  agreement,  originally effective September 30, 1997 (the "Employment
Agreement");

     WHEREAS,  Employee is currently  employed as the Chief Executive Officer of
the  Company,  and serves as Chairman of the Board of  Directors  of the Company
(the "Board");

     WHEREAS,  the  Company  and  Employee  desire  to  amend  and  restate  the
Employment  Agreement  to  modify  certain  terms of the  Employment  Agreement,
effective as of the date set forth above or such other date as specified herein.

     NOW  THEREFORE,  in  consideration  of the  premises  and mutual  covenants
contained  herein and for other good and  valuable  consideration,  the  parties
agree as follows:

     1. Term.  The Company agrees to continue to employ  Employee,  and Employee
agrees to continue to serve, on the terms and conditions of this Agreement for a
period  commencing  on the date  hereof  and  ending  three  years from the date
hereof,  or such other  period as may be  provided  for in Section 10 or 11. The
period during which Employee is employed hereunder is hereinafter referred to as
the "Employment  Period." The Employment  Period shall be automatically  renewed
for  successive  one-year terms unless either party gives written notice to  the
other at least six (6) months  prior to the  expiration  of the then  Employment
Period, of such party's intention to terminate  Employee's  employment hereunder
at the end of the then current Employment Period.

     2.  Duties and  Services.  During the  Employment  Period,  Employee  shall
continue  to be  employed  in the  business  of the  Company as Chief  Executive
Officer  of the  Company.  In  addition,  Employee  shall  continue  to serve as
Chairman of the Board.  Employee shall perform such duties and services,  within
his expertise and  experience,  as may be assigned to him by, and subject to the
direction of, the Board. Employee agrees to continue his employment as described
in this  Section 2 and agrees to devote all of his  working  time and efforts to
the  performance  of his duties under this  Agreement,  excepting  disabilities,
illness and vacation time as provided by Section 3(e). In performing  his duties
hereunder, Employee shall be available for reasonable travel as the needs of the
business  require.  Except as provided in Section 6 hereof,  the foregoing shall
not be construed as preventing  Employee from:  (i) making



<PAGE>


investments  in other  businesses  and managing  his and his  family's  personal
investments;   and  (ii)  participating  in  charitable,   civic,   educational,
professional, community or industry affairs or serving on the board of directors
of other companies ("Professional Activities"), provided that these Professional
Activities are approved by the Company's Board.

     3.   Compensation and Other Benefits.

     (a) As  compensation  for his  services  hereunder,  the Company  shall pay
Employee,  during  the  Employment  Period,  a  base  salary  payable  in  equal
semi-monthly  installments  at an annual rate of  $300,000,  provided  that such
salary  shall be  reviewed  annually  by the  Company's  Board,  or a  committee
thereof,  which may, in its sole  discretion,  increase (but not decrease)  such
salary.

     (b) The Company shall also pay Employee,  during the Employment  Period, an
annual target bonus,  payable in January of each year for the preceding year, in
an amount equal to sixty-five  percent (65%) of Employee's  base salary (payable
under Section 3(a) of this Agreement)  measured against objective criteria to be
determined  by the Company's  Board,  or a committee  thereof,  after good faith
consultation with Employee.

     (c)  Employee  shall be entitled to  continue to  participate  in all group
health and insurance  programs and all other fringe benefit or retirement  plans
which  the  Company  may,  in its sole and  absolute  discretion,  elect to make
available to its employees generally, provided Employee meets the qualifications
therefor.

     (d) Employee  shall be eligible to  participate in the Company's 1998 Long-
Term Incentive Plan (the "Plan") and any other  incentive  plans of the Company.
Upon  the  Employee's  Disability  (as  defined  in the  Plan),  termination  of
employment with the Company due to Retirement (as defined in the Plan) or death,
Employee (or the legal  representative  of his estate, in the case of Employee's
death) shall be entitled to: (i) full vesting and  immediate  exercisability  of
any  outstanding  stock  options  and  other  equity  awards  (and  lapse of any
forfeiture provisions) granted to Employee at any time; and (ii) with respect to
stock options granted to Employee on or after January 1, 2000,  Employee (or the
legal  representative  of his estate,  in the case of Employee's death) shall be
entitled  to exercise  such stock  options at any time during the three (3) year
period from the date of Employee's Disability, Retirement or death.

     (e)  Employee  shall be  entitled to four weeks of paid  vacation  per year
during the Employment Period.

     4. Expenses. Employee shall be entitled to reimbursement for all reasonable
travel and other out-of-pocket  expenses necessarily incurred in the performance
of his duties hereunder,  upon submission and approval of written statements and
bills in accordance with the then regular procedures of the Company.


                                        2

<PAGE>


     5.  Representations  and  Warranties of Employee.  Employee  represents and
warrants  to the  Company  that  Employee  is  under  no  contractual  or  other
restriction  or  obligation  which is  inconsistent  with the  execution of this
Agreement,  the  performance of his duties  hereunder or the other rights of the
Company hereunder.

     6.   Non-Competition.

     (a) In view of the unique and valuable  services that Employee has rendered
or is expected to render to the Company,  Employee's knowledge of the customers,
trade secrets and other proprietary  information relating to the business of the
Company and its  customers and  suppliers  and similar  knowledge  regarding the
Company  which  Employee  has  obtained  or  is  expected  to  obtain,   and  in
consideration  of the  compensation  to be received  hereunder,  Employee agrees
that:

          (i)  during  the  period he is  employed  by the  Company  under  this
     Agreement or otherwise,  he will not Participate In (as hereinafter defined
     in this Section 6) any other business or organization,  whether or not such
     business or  organization  now is or shall then be  competing  with or of a
     nature similar to the business of the Company,  without obtaining the prior
     written consent of the Executive Committee of the Board;

          (ii) until the first  anniversary  of the date of the  termination  of
     Employee's  employment  under  this  Agreement  or  otherwise,  he will not
     Participate  In any business which is engaged,  directly or indirectly,  in
     the same  business as the Company with  respect to any specific  product or
     specific  service  sold or activity in which the Company  engages up to the
     time of termination of employment in any geographical  area in which at the
     time of termination  such product or service is sold or activity is engaged
     in by the Company;

          (iii) if a Change in Control occurs and Employee's employment with the
     Company is terminated  under this Agreement  without Cause (as  hereinafter
     defined) or by Employee  for Good  Reason (as  hereinafter  defined) at any
     time  during the period  beginning  on the date of a Change in Control  and
     ending  one (1) year  after the date of such  Change in  Control  or within
     ninety (90) days prior to a Change in Control,  then beginning on the later
     of the date  Employee's  employment  terminates  (as  described  under this
     Section  6(a)(iii))  and the date of a Change in Control  and ending on the
     second anniversary of such date, he will not Participate In any activity or
     business  in the  United  States  involved  in the  research,  development,
     commercialization  of a small molecule which is: (A) the generic equivalent
     of THALOMID (i.e.,  the same chemical  structure);  (B) an  anti-angiogenic
     agent for oncology use; (C) a  substantially  specific  TNFalpha  inhibitor
     (via inhibition of synthesis of TNFalpha, including via inhibition of PDE4)
     for the treatment of Crohn's disease, rheumatoid arthritis,  dermatological
     and  auto-immune  conditions  having excess levels of TNFalpha as the prime
     causative  factor,  cachexia (AIDS or cancer),  or any other indication for
     which the Company has been granted orphan drug status; or (D) a formulation
     of d- or dl-methylphenidate for the treatment of ADD/ADHD.


                                        3

<PAGE>


     (b) For  purposes of this Section 6 the term  "Participate  In" shall mean:
"directly or  indirectly,  for his own benefit or for, with or through any other
person, firm or corporation,  own, manage,  operate,  control,  loan money to or
participate  in the  ownership,  management,  operation  or  control  of,  or be
connected  as  a  director,  officer,  employee,  partner,  consultant,   agent,
independent  contractor  or otherwise  with, or acquiesce in the use of his name
in."

     (c) Employee  further agrees that,  during the period he is employed by the
Company under this Agreement or otherwise and until the first anniversary of the
date of the  termination  of  Employee's  employment  under  this  Agreement  or
otherwise,  he will not directly or  indirectly  reveal the name of,  solicit or
interfere  with,  or  endeavor  to  entice  away  from the  Company,  any of its
suppliers, customers or employees.

     7. Patents, etc. Any interest in patents, patent applications,  inventions,
technological  innovations,   copyrights,   copyrightable  works,  developments,
discoveries,  designs and processes  ("Inventions")  which  Employee  during the
period he is employed by the Company under this Agreement or otherwise,  and for
six months  thereafter,  may  conceive of or develop and either  relating to the
specific  fields in which the  Company  may then be engaged or  conceived  of or
developed utilizing the time, material, facilities or information of the Company
shall  belong to the Company;  as soon as Employee  conceives of or develops any
Invention,  he agrees  immediately  to  communicate  such fact in writing to the
Secretary of the Company, and without further compensation, but at the Company's
expense  (except  as noted in clause  (a) of this  Section  7),  forthwith  upon
request of the Company,  Employee shall execute all such  assignments  and other
documents  (including  applications  for  patents,  copyrights,  trademarks  and
assignments  thereof)  and  take  all  such  other  action  as the  Company  may
reasonably  request in order (a) to vest in the  Company all  Employee's  right,
title and interest in and to the Inventions, free and clear of liens, mortgages,
security interests,  pledges,  charges and encumbrances arising from the acts of
Employee  ("Liens")  (Employee  to  take  such  action,  at his  expense,  as is
necessary to remove all such Liens) and (b) if patentable or  copyrightable,  to
obtain patents or copyrights (including extensions and renewals) therefor in any
and all countries in such name as the Company shall determine.

     8. Confidential  Information.  All confidential  information which Employee
may now possess, may obtain during or after the Employment Period, or may create
prior  to the  end of the  period  he is  employed  by the  Company  under  this
Agreement  or  otherwise  relating  to the  business  of the  Company  or of any
customer or supplier of the Company  shall not be  published,  disclosed or made
accessible  by him to any other  person,  firm or  corporation  either during or
after  the  termination  of his  employment  or used by him  except  during  the
Employment  Period in the business  and for the benefit of the Company,  in each
case without the prior written permission of the Company.  Employee shall return
all tangible evidence of such  confidential  information to the Company prior to
or  at  the  termination  of  his  employment.   As  used  in  this  Section  8,
"confidential  information"  shall mean any information  except that information
which is or comes into the public domain through no fault of Employee or which


                                        4

<PAGE>


Employee  obtains after the  termination  of his employment by the Company under
this  Agreement  or  otherwise  from a third party who has the right to disclose
such information.

     9. Life  Insurance.  If requested by the Company,  Employee shall submit to
such  physical  examinations  and  otherwise  take such  actions and execute and
deliver such documents as may be reasonably  necessary to enable the Company, at
its expense and for its own  benefit,  to obtain life  insurance  on the life of
Employee.  Subject to its  ability to do so under the terms of such  policy,  if
any,  insuring  the  life  of  Employee,  upon  the  termination  of  Employee's
employment hereunder,  the Company will assign to Employee its rights under such
insurance policy,  provided that,  concurrently  with such assignment,  Employee
shall  reimburse  the Company for any  premium  payments  made by the Company in
respect of time periods  subsequent to such date of termination.  Nothing herein
contained shall obligate the Company to obtain such insurance.

     10.  Termination.

     (a) Employee's  employment and the Employment Period shall terminate on the
first of the following to occur:

          (i) the Company  provides  written notice to Employee of a termination
     for Cause;  such written notice shall be provided to Employee not less than
     ten (10) days prior to the date of  termination.  "Cause"  shall mean:  (A)
     Employee's conviction of a crime involving moral turpitude or a felony, (B)
     Employee's acts or omissions taken in bad faith and to the detriment of the
     Company  after a written  demand for cessation of such conduct is delivered
     to Employee by the Company, which demand specifically identifies the manner
     in which the Company believes that Employee has engaged in such conduct and
     the injury to the Company, and after Employee's failure to correct such act
     or omission  within ten (10) days  following  such written  demand,  or (C)
     Employee's  breach of any material  term of this  Agreement  after  written
     demand for substantial performance is delivered to Employee by the Company,
     which  demand  specifically  identifies  the  manner in which  the  Company
     believes Employee has breached this Agreement, and after Employee's failure
     to correct such breach within ten (10) days following such written demand.

          (ii)  Employee's  death, in which case, this Agreement shall terminate
     on the date of Employee's death,  whereupon  Employee or his estate, as the
     case may be,  shall be  entitled to receive a lump sum payment in an amount
     equal to Employee's  annual base salary (at the rate in effect, or required
     to be in effect, immediately prior to the date of Employee's death) and the
     portion of  Employee's  annual  target bonus (as provided in Section  3(b))
     pro-rated  up to  Employee's  date of death  (assuming  the target has been
     met).

          (iii) Nothing contained in this Section 10(a) shall be deemed to limit
     any other  right the Company may have to  terminate  Employee's  employment
     hereunder upon any ground permitted by law.


                                        5

<PAGE>


          (iv) If Employee's employment is terminated by the Company as a result
     of the  disability  or  incapacitation  of Employee or for any reason other
     than pursuant to the  provisions of paragraphs  (i) or (ii) of this Section
     10(a) or the provisions of Section 10(b),  upon  termination by the Company
     of  Employee's   employment,   whether  during  the  Employment  Period  or
     thereafter,  Employee shall be entitled to receive a lump sum payment in an
     amount equal to  Employee's  annual base salary (at the rate in effect,  or
     required  to be in  effect,  immediately  prior to the  date of  Employee's
     termination) and the portion of Employee's annual target bonus (as provided
     in  Section  3(b))   pro-rated  up  to  Employee's   date  of   disability,
     incapacitation or termination (assuming the target has been met).

          (v) In the event of the  Employee's  termination  for any reason under
     this Agreement or otherwise,  the Company shall pay and provide to Employee
     (in  addition  to  any  other  payments  or  benefits  payable  under  this
     Agreement):  (A) any  incurred  but  reimbursed  business  expenses for the
     period prior to the  termination  payable in accordance  with the Company's
     policies;  (B) any base  salary,  bonus,  vacation  pay or  other  deferred
     compensation  accrued  or  earned  under  law  or in  accordance  with  the
     Company's  policies  applicable  to Employee but not yet paid;  and (C) any
     other  amounts  or  benefits  due under  the  terms of the then  applicable
     employee  benefit,  equity or incentive plans of the Company  applicable to
     Employee (the "Accrued Benefits").

          (vi)  Payments of any amounts or benefits  hereunder  shall be made no
     later  than ten (10) days after  Employee's  termination  date,  other than
     benefits under a plan with the terms which do not require or permit payment
     within such ten (10) day period.

     (b) During the ninety (90) day period  prior to Change in Control or during
the one (1) year period  following a Change in Control,  Employee may  terminate
his employment by written notice to the Company within thirty (30) calendar days
after he has obtained actual knowledge of the occurrence of a Good Reason event.
For purposes of this Agreement,  Good Reason shall mean the occurrence of any of
the following events without Employee's express written consent:

          (i) failure to elect or appoint, or reelect or reappoint, Employee to,
     or  removal  of  Employee  from,  his  position  with the  Company as Chief
     Executive  Officer or Chairman of the Board,  except in connection with the
     termination of Employee's employment pursuant to Section 10(a);

          (ii) a significant  change in the nature or scope of the  authorities,
     powers,   functions,   duties  or  responsibilities  normally  attached  to
     Employee's  position as Chief  Executive  Officer or Chairman of the Board,
     except  in each  case in  connection  with the  termination  of  Employee's
     employment for Cause or as a result of Employee's  death, or temporarily as
     a result of Employee's illness or other absence;

          (iii) a determination by Employee made in good faith that, as a result
     of a  Change  in  Control,  he is  unable  effectively  to  carry  out  the
     authorities,  powers,


                                        6

<PAGE>


     functions,  duties or  responsibilities  attached to his  position as Chief
     Executive  Officer  or  Chairman  of the  Board  and the  situation  is not
     remedied  within 30 calendar  days after  receipt by the Company of written
     notice from Employee of such determination;

          (iv) a  breach  by the  Company  of any  material  provision  of  this
     Agreement  (not covered by clause (i), (ii) or (iii) of this Section 10(b))
     or of any other  agreement,  which is not remedied  within 30 calendar days
     after  receipt by the  Company  of written  notice  from  Employee  of such
     breach;

          (v) a reduction in Employee's annual base salary;

          (vi) a  fifty  (50)  mile  or  greater  relocation  of  the  Company's
     principal office;

          (vii)  failure  of the  Company  to  continue  in effect any health or
     welfare plan,  employee benefit plan,  pension plan, fringe benefit plan or
     compensation   plan  in  which  Employee  (and  eligible   dependents)  are
     participating  immediately  prior to a Change in Control,  unless  Employee
     (and  eligible  dependents)  are  permitted to  participate  in other plans
     providing Employee (and eligible dependents) with substantially  comparable
     benefits  at  no  greater   after-tax   cost  to  Employee   (and  eligible
     dependents),  or the  taking  of any  action  by the  Company  which  would
     adversely affect the Employee's (and eligible dependents)  participation in
     or reduce  Employee's  (and eligible  dependents)  benefits  under any such
     plan; or

          (viii) failure of a successor to assume this Agreement.

     An election by Employee to terminate his employment under the provisions of
this Section 10(b) shall not  constitute a breach by Employee of this  Agreement
and shall not be deemed a voluntary  termination  of  employment by Employee for
the purpose of  interpreting  the  provisions of any of the  Company's  employee
benefit plans, programs or policies.

     (c) Upon the  occurrence  of a Change in  Control  and  thereafter:  (A) if
Employee's  employment  with the Company is  terminated  by the Company  without
Cause or as a result of the  disability  or  incapacitation  of Employee,  or by
Employee with Good Reason at any time during the period beginning on the date of
the Change in Control  and ending one (1) year after the date of such  Change in
Control,  or (B) if Employee's  employment with the Company is terminated by the
Company  without  Cause or by Employee for Good Reason  within  ninety (90) days
prior to the occurrence of a Change in Control,  then Employee shall be entitled
to receive from the Company:

          (i) a lump sum  amount,  payable  within  ten  (10)  days  after  such
     termination (or, if such termination occurred prior to a Change in Control,
     within ten (10) days after the  Change in  Control)  equal to (A) three (3)
     times  Employee's  base  salary in  effect,  or  required  to be in effect,
     immediately  prior to the  Change in  Control,


                                        7

<PAGE>


     and (B) three (3)  times  the  highest  annual  bonus  paid or  payable  to
     Employee within three (3) years prior to the Change in Control;

          (ii)  within  ten  (10)  days  after  such  termination  (or,  if such
     termination  occurred  prior to a Change in  Control,  within ten (10) days
     after the Change in Control) equal to the Accrued Benefits;

          (iii)  payment by the Company of the premiums for Employee  (except in
     the case of Employee's  death) and  Employee's and  dependents'  health and
     welfare coverage  (including,  without  limitation,  medical,  dental, life
     insurance  and  disability  coverage) for three (3) years from the later of
     the  occurrence  of a  Change  in  Control  or the date of  termination  of
     Employee's  employment,  under the Company's health and welfare plans which
     cover the senior  executives of the Company or materially  similar benefits
     ("Continuation  Coverage"),  subject to  Employee's  payment  of  customary
     premiums (if any) in effect prior to the Change in Control;

          (iv) upon the  occurrence  of a Change in Control,  full and immediate
     vesting of all stock options and equity awards held by Employee.

     Payments under (iii) above may, at the  discretion of the Company,  be made
by continuing Employee's  participation in the plan as a terminee or by covering
Employee and Employee's dependents under substitute arrangements, provided that,
notwithstanding  anything herein to the contrary,  to the extent Employee incurs
tax that Employee  would not have incurred as an active  employee as a result of
the aforementioned coverage or the benefits provided thereunder,  Employee shall
receive  from the  Company  an  additional  grossed  up  payment  in the  amount
necessary so that Employee will have no additional cost for receiving such items
or any  additional  payment.  Notwithstanding  anything  herein to the contrary,
Employee  (and his  eligible  dependents)  shall  retain  all  rights  under the
Consolidated Omnibus Budget Reconciliation Act of 1985, as amended ("COBRA") and
such  COBRA  continuation  coverage  shall be  available  to  Employee  (and his
eligible  dependents) at the expiration of the Continuation  Coverage  described
herein.

     (d) For  purposes  of this  Agreement,  a Change in Control  shall mean the
occurrence of the following:

          (i) any person  (as  defined  in  Section  3(a)(9)  of the  Securities
     Exchange  Act of 1934,  as  amended  (the  "Exchange  Act")  and as used in
     Sections 13(d) and 14(d) thereof), excluding the Company, any subsidiary of
     the Company and any employee  benefit plan  sponsored or  maintained by the
     Company or any subsidiary of the Company (including any trustee of any such
     plan acting in his capacity as trustee),  becoming the  "beneficial  owner"
     (as  defined in Rule 13d-3 under the  Exchange  Act) of  securities  of the
     Company  representing  thirty  percent (30%) of the total  combined  voting
     power of the Company's then outstanding securities;


                                        8

<PAGE>


          (ii) the merger,  consolidation  or other business  combination of the
     Company (a "Transaction"),  other than (A) a Transaction involving only the
     Company  and  one  or  more  of  its  subsidiaries,  or  (B) a  Transaction
     immediately  following which the  stockholders  of the Company  immediately
     prior to the Transaction continue to have a majority of the voting power in
     the  resulting  entity  and no person  (other  than  those  covered  by the
     exceptions in (a) above) becomes the beneficial  owner of securities of the
     resulting entity  representing  more than twenty-five  percent (25%) of the
     voting power in the resulting entity;

          (iii) during any period of two (2)  consecutive  years beginning on or
     after  the  date  hereof,  the  persons  who  were  members  of  the  Board
     immediately before the beginning of such period (the "Incumbent Directors")
     ceasing (for any reason other than death) to constitute at least a majority
     of the Board or the board of  directors  of any  successor  to the Company,
     provided  that,  any  director who was not a director as of the date hereof
     shall be deemed to be an Incumbent Director if such director was elected to
     the board of directors by, or on the recommendation of or with the approval
     of, at least  two-thirds of the  directors who then  qualified as Incumbent
     Directors  either  actually or by prior  operation of the foregoing  unless
     such election,  recommendation  or approval occurs as a result of an actual
     or threatened  election  contest (as such terms are used in Rule 14a- 11 of
     Regulation  14A  promulgated  under  the  Exchange  Act  or  any  successor
     provision)  or other  actual  or  threatened  solicitation  of  proxies  or
     contests by or on behalf of a person other than a member of the Board; or

          (iv) the  approval by the  stockholders  of the Company of any plan of
     complete  liquidation of the Company or an agreement for the sale of all or
     substantially  all of the  Company's  assets  other than the sale of all or
     substantially  all of the assets of the  Company to a person or persons who
     beneficially own,  directly or indirectly,  at least fifty percent (50%) or
     more of the combined voting power of the outstanding  voting  securities of
     the Company at the time of such sale.

     (v) To the extent that  Employee is entitled to payment under Section 10(c)
upon a Change in Control due to Employee's termination without Cause or for Good
Reason within  ninety (90) days prior to a Change in Control,  any such payments
under Section 10(c) shall be reduced by any payments made to Employee prior to a
Change in Control under Sections 10(a)(iv) and 10(a)(v).

     11.  Limitation on Payments.

     (a) In the event that Employee shall become entitled to the payments and/or
benefits provided by Section 10(c) or any other amounts (whether pursuant to the
terms of this  Agreement or any other plan,  arrangement  or agreement  with the
Company,  any person whose  actions  result in a change of ownership  covered by
Section 280G(b)(2) of the Internal Revenue Code of 1986, as amended (the "Code")
or any  person  affiliated  with the  Company  or such  person) as a result of a
Change of  Control  (collectively  the  "Company  Payments"),  and such  Company
Payments  will be subject to the tax (the "Excise  Tax") imposed by Section 4999
of


                                        9

<PAGE>


the Code (and any similar tax that may  hereafter be imposed) the Company  shall
pay to Employee at the time  specified  in  subsection  (d) below an  additional
amount (the "Gross-up  Payment") such that the net amount  retained by Employee,
after  deduction  of any Excise Tax on the  Company  Payments  and any  federal,
state, and local income or payroll tax upon the Gross-up Payment provided for by
this  paragraph  (a), but before  deduction  for any federal,  state,  and local
income or payroll  tax on the  Company  Payments,  shall be equal to the Company
Payments.  Notwithstanding  the  foregoing  provisions of this Section 11 to the
contrary,  if it shall be  determined  that  Employee  is entitled to a Gross-up
Payment,  but the Company Payments do not exceed one hundred five percent (105%)
of the greatest  amount that could be paid to Employee  such that the receipt of
Company  Payments would not give rise to any Excise Tax (the "Reduced  Amount"),
then no Gross-up Payment shall be made to Employee and the Company Payments,  in
the aggregate, shall be reduced to the Reduced Amount.

     (b) For  purposes of  determining  whether any of the Company  Payments and
Gross-up  Payments  (collectively  the "Total  Payments") will be subject to the
Excise Tax and determining the amount of such Excise Tax: (i) the Total Payments
shall  be  treated  as  "parachute  payments"  within  the  meaning  of  Section
280G(b)(2)  of the Code,  and all  "parachute  payments"  in excess of the "base
amount" (as defined under Code Section  280G(b)(3) of the Code) shall be treated
as subject  to the Excise  Tax,  unless  and except to the extent  that,  in the
opinion of the Company's  independent  certified  public  accountants  appointed
prior to any change in ownership (as defined under Code Section  280G(b)(2))  or
tax counsel selected by such accountants (the "Accountants") such Total Payments
(in whole or in part), (A) do not constitute "parachute payments," (B) represent
reasonable  compensation  for services  actually  rendered within the meaning of
Section  280G(b)(4)  of the Code" or (C) are otherwise not subject to the Excise
Tax;  and (ii) the value of any  non-cash  benefits or any  deferred  payment or
benefit shall be determined by the Accountants in accordance with the principles
of Section 280G of the Code.

     (c) For  purposes  of  determining  the  amount  of the  Gross-up  Payment,
Employee  shall be deemed to pay federal  income  taxes at the highest  marginal
rate of federal  income  taxation  in the  calendar  year in which the  Gross-up
Payment is to be made and state and local income  taxes at the highest  marginal
rate of  taxation  in the state and  locality of  Employee's  residence  for the
calendar  year in which the  Company  Payment is to be made,  net of the maximum
reduction in federal income taxes which could be obtained from deduction of such
state and local taxes if paid in such year.  In the event that the Excise Tax is
subsequently determined by the Accountants to be less than the amount taken into
account hereunder at the time the Gross-up Payment is made, Employee shall repay
to the Company,  at the time that the amount of such  reduction in Excise Tax is
finally  determined,  the portion of the prior Gross-up Payment  attributable to
such reduction  (plus the portion of the Gross-up  Payment  attributable  to the
Excise Tax and federal, state and local income tax imposed on the portion of the
Gross-up  Payment  being  repaid by  Employee  if such  repayment  results  in a
reduction  in Excise Tax or a federal,  state and local  income tax  deduction),
plus  interest on the amount of such  repayment at the rate  provided in Section
1274(b)(2)(B)  of the  Code.  Notwithstanding  the  foregoing,  in the event any
portion of the  Gross-up  Payment to be refunded to the Company has been paid to
any  federal,  state and local tax  authority,  repayment  thereof  (and related
amounts) shall not be


                                       10

<PAGE>


required  until  actual  refund  or  credit  of such  portion  has been  made to
Employee,  and  interest  payable to the Company  shall not exceed the  interest
received or credited  to Employee by such tax  authority  for the period it held
such portion.  Employee and the Company shall  mutually agree upon the course of
action to be pursued  (and the method of  allocating  the  expense  thereof)  if
Employee's claim for refund or credit is denied.

     In the event that the Excise Tax is later  determined by the Accountants or
the Internal  Revenue Service to exceed the amount taken into account  hereunder
at the time the Gross-up Payment is made (including by reason of any payment the
existence  or amount of which cannot be  determined  at the time of the Gross-up
Payment),  the Company shall make an additional  Gross-up  Payment in respect of
such excess (plus any interest or penalties payable with respect to such excess)
at the time that the amount of such excess is finally determined.

     (d) The Gross-up  Payment or portion thereof provided for in subsection (c)
above shall be paid not later than the  thirtieth  (30th) day following an event
occurring which sub jects Employee to the Excise Tax; provided, however, that if
the  amount of such  Gross-up  Payment  or  portion  thereof  cannot be  finally
determined  on or before such day, the Company shall pay to Employee on such day
an estimate,  as  determined  in good faith by the  Accountants,  of the minimum
amount of such payments and shall pay the  remainder of such payments  (together
with interest at the rate provided in Code Section  1274(b)(2)(B)  of the Code),
subject to further  payments  pursuant to subsection (c) hereof,  as soon as the
amount  thereof can  reasonably  be  determined,  but in no event later than the
ninetieth  (90th) day after the occurrence of the event  subjecting  Employee to
the Excise Tax. In the event that the amount of the estimated  payments  exceeds
the  amount  subsequently  determined  to  have  been  due,  such  excess  shall
constitute  a loan by the  Company to  Employee,  payable on the fifth (5th) day
after  demand by the Company  (together  with  interest at the rate  provided in
Section 1274(b)(2)(B) of the Code).

     (e) In the event of any controversy  with the Internal  Revenue Service (or
other taxing authority) under this Section 11, Employee shall permit the Company
to control  issues  related to this Section 11 (at its  expense),  provided that
such  issues  do not  potentially  materially  adversely  affect  Employee,  but
Employee  shall  control  any  other  issues.   In  the  event  the  issues  are
interrelated,  Employee and the Company shall in good faith  cooperate so as not
to  jeopardize  resolution  of either  issue,  but if the parties  cannot agree,
Employee shall make the final  determination  with regard to the issues.  In the
event of any  conference  with any  taxing  authority  as to the  Excise  Tax or
associated income taxes, Employee shall permit the representative of the Company
to accompany him, and Employee and his  representative  shall cooperate with the
Company and its representative.

     (f) The Company shall be responsible for all charges of the Accountants.

     12.  Successors.  In  addition to any  obligations  imposed by law upon any
successor to the Company, the Company will require any successor (whether direct
or  indirect,  by  purchase,  merger,  consolidation  or  otherwise)  to  all or
substantially  all of the  business  and/or  assets of the Company to  expressly
assume and agree in writing to perform this


                                       11

<PAGE>


Agreement  in the same manner and to the same  extent that the Company  would be
required to perform it if no such succession had taken place.

     13. Survival.  The covenants,  agreements,  representations  and warranties
contained  in or  made  pursuant  to this  Agreement  shall  survive  Employee's
termination of employment.

     14. Entire  Agreement;  Modification.  This Agreement sets forth the entire
understanding  of the  parties  with  respect  to  the  subject  matter  hereof,
supersedes all existing  agreements  between them concerning such subject matter
(including,  without limitation, the employment agreement in effect prior to the
date hereof) and may be modified only by a written  instrument  duly executed by
each party.

     15. Notices. Any notice or other communication  required or permitted to be
given  hereunder  shall be in  writing  and shall be mailed by  certified  mail,
return receipt  requested,  or delivered against receipt to the party to whom it
is to be given at the  address of such party set forth in the  preamble  to this
Agreement (or to such other address as the party shall have furnished in writing
in accordance  with the provisions of this Section 15).  Notice to the estate of
Employee  shall be  sufficient  if  addressed  to  Employee  as provided in this
Section 15. Any notice or other  communication  given by certified mail shall be
deemed given three days after the time of  certification  thereof,  except for a
notice  changing a party's  address  which shall be deemed  given at the time of
receipt thereof.

     16. Waiver. Any waiver by either party of a breach of any provision of this
Agreement  shall  not  operate  as or be  construed  to be a waiver of any other
breach  of such  provision  or of any  breach  of any  other  provision  of this
Agreement. The failure of a party to insist upon strict adherence to any term of
this  Agreement  on one or more  occasions  shall not be  considered a waiver or
deprive that party of the right  thereafter  to insist upon strict  adherence to
that term or any other term of this  Agreement.  Any waiver  must be in writing,
signed by the party giving such waiver.

     17. Binding Effect.  Employee's rights and obligations under this Agreement
shall not be transferable  by assignment or otherwise,  such rights shall not be
subject to commutation,  encumbrance or the claims of Employee's creditors,  and
any attempt to do any of the  foregoing  shall be void.  The  provisions of this
Agreement  shall be binding  upon and inure to the benefit of  Employee  and his
heirs and personal  representatives,  and shall be binding upon and inure to the
benefit of the Company and its successors and its assigns under Section 12.

     18. No Third Party Beneficiaries. This Agreement does not create, and shall
not be construed as creating,  any rights  enforceable by any person not a party
to this Agreement (except as provided in Sections 12 and 17).

     19. Legal Fees. To the fullest  extent  permitted by law, the Company shall
promptly pay upon  submission  of  statements  all legal and other  professional
fees, costs of litigation,  prejudgment interest, and other expenses incurred in
connection with any dispute


                                       12

<PAGE>


concerning payments,  benefits and other entitlements to which Employee may have
under this  Agreement;  provided,  however,  the Company  shall be reimbursed by
Employee for the fees and expenses advanced in the event Employee's claim is, in
a material  manner,  in bad faith or frivolous and the  arbitrator or court,  as
applicable,  determines  that the  reimbursement  of such fees and  expenses  is
appropriate.

     20.  Pooling of  Interests;  Severability.  In the event that the Company's
independent  public  accountants  determine in good faith that any  provision of
this  Agreement  would preclude  "pooling of interests"  accounting and provided
that the Company engages in a transaction  which utilizes "pooling of interests"
accounting, such provision shall be deemed invalid and inoperative solely to the
extent necessary to permit "pooling of interests"  transactions.  If any portion
of this Agreement is held invalid or inoperative  (including a determination  by
the Company's independent public accountants in good faith that any provision of
this Agreement  would  preclude  "pooling of interests"  accounting),  the other
provisions of this  Agreement  shall be deemed to be valid and operative and, so
far as is  reasonable  and  possible,  effect  shall  be  given  to  the  intent
manifested by the portion held valid or inoperative.

     21. No Duty to  Mitigate/No  Offset.  The Company agrees that if Employee's
employment with the Company is terminated  pursuant to this Agreement during the
term of this Agreement,  Employee shall not be required to seek other employment
or to attempt  in any way to reduce  any  amounts  payable  to  Employee  by the
Company  pursuant  to this  Agreement.  Further,  the  amount of any  payment or
benefit  provided for in this Agreement shall not be reduced by any compensation
earned by Employee or benefit  provided to Employee as the result of  employment
by another employer or otherwise. The Company's obligations to make the payments
provided  for in  this  Agreement  and  otherwise  to  perform  its  obligations
hereunder  shall  not  be  affected  by  any  circumstances,  including  without
limitation, any set-off, counter claim, recoupment, defense or other right which
the Company may have against Employee.  Notwithstanding the foregoing,  payments
and benefits  under the  Agreement  will cease to be paid and may be recouped by
the Company in the event Employee breaches any of the terms of Section 6, 7 or 8
hereunder.

     22.  Counterparts;  Governing  Law.  This  Agreement may be executed in any
number of  counterparts,  each of which shall be deemed an original,  but all of
which  together  shall  constitute  one and the  same  instrument.  It  shall be
governed  by and  construed  in  accordance  with the  laws of the  State of New
Jersey, without giving effect to the conflict of laws.


                                       13

<PAGE>


     IN WITNESS WHEREOF, the parties have duly executed this Agreement as of the
date first above written.

                                                CELGENE CORPORATION


                                                By:
                                                   -----------------------------
                                                     Richard C. E. Morgan
                                                     Chairman of the
                                                     Compensation Committee


                                                By:
                                                   -----------------------------
                                                     Sol J. Barer
                                                     President




                                                --------------------------------
                                                John W. Jackson


                                       14




                                                                   EXHIBIT 10.11

                    AMENDED AND RESTATED EMPLOYMENT AGREEMENT

     THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this "Agreement"), dated as
of January 1, 2000,  between Celgene  Corporation,  a Delaware  corporation with
offices at 7 Powder Horn Drive,  Warren,  New Jersey 07059 (the "Company"),  and
Sol J. Barer,  residing at 625  Westfield  Avenue,  Westfield,  New Jersey 07090
("Employee").

                               W I T N E S S E T H
                               - - - - - - - - - -

     WHEREAS,   the  Company  and  Employee  have  previously  entered  into  an
employment  agreement,  originally effective September 30, 1997 (the "Employment
Agreement");

     WHEREAS,  Employee is currently  employed as the  President of the Company,
and serves as a member of the Board of Directors of the Company (the "Board");

     WHEREAS,  the  Company  and  Employee  desire  to  amend  and  restate  the
Employment  Agreement  to  modify  certain  terms of the  Employment  Agreement,
effective as of the date set forth above or such other date as specified herein.

     NOW  THEREFORE,  in  consideration  of the  premises  and mutual  covenants
contained  herein and for other good and  valuable  consideration,  the  parties
agree as follows:

     1. Term.  The Company agrees to continue to employ  Employee,  and Employee
agrees to continue to serve, on the terms and conditions of this Agreement for a
period  commencing  on the date  hereof  and  ending  three  years from the date
hereof,  or such other  period as may be  provided  for in Section 10 or 11. The
period during which Employee is employed hereunder is hereinafter referred to as
the "Employment  Period." The Employment  Period shall be automatically  renewed
for  successive  one-year  terms unless either party gives written notice to the
other at least six (6) months  prior to the  expiration  of the then  Employment
Period, of such party's intention to terminate  Employee's  employment hereunder
at the end of the then current Employment Period.

     2. Duties and Services.  During the  Employment  Period,  Employee shall be
employed in the business of the Company as President and Chief Operating Officer
of the Company. In addition, Employee shall continue to serve as a member of the
Board. Employee shall perform such duties and services, within his expertise and
experience,  as may be assigned to him by, and subject to the  direction of, the
Chief  Executive  Officer  and  the  Board.  Employee  agrees  to  continue  his
employment  as  described  in this  Section 2 and  agrees  to devote  all of his
working time and efforts to the  performance of his duties under this Agreement,
excepting  disabilities,  illness and vacation time as provided by Section 3(e).
In performing his duties  hereunder,  Employee shall be available for reasonable
travel as the needs


<PAGE>


of the business require.  Except as provided in Section 6 hereof,  the foregoing
shall not be construed as preventing  Employee from:  (i) making  investments in
other  businesses and managing his and his family's  personal  investments;  and
(ii) participating in charitable, civic, educational, professional, community or
industry  affairs  or  serving  on the  board of  directors  of other  companies
("Professional  Activities"),  provided that these  Professional  Activities are
approved by the Company's Board.

     3.   Compensation and Other Benefits.

     (a) As  compensation  for his  services  hereunder,  the Company  shall pay
Employee,  during  the  Employment  Period,  a  base  salary  payable  in  equal
semi-monthly  installments  at an annual rate of  $258,000,  provided  that such
salary  shall be  reviewed  annually  by the  Company's  Board,  or a  committee
thereof,  which may, in its sole  discretion,  increase (but not decrease)  such
salary.

     (b) The Company shall also pay Employee,  during the Employment  Period, an
annual target bonus,  payable in January of each year for the preceding year, in
an amount equal to forty-five  percent (45%) of Employee's  base salary (payable
under Section 3(a) of this Agreement)  measured against objective criteria to be
determined  by the Company's  Board,  or a committee  thereof,  after good faith
consultation with Employee.

     (c)  Employee  shall be entitled to  continue to  participate  in all group
health and insurance  programs and all other fringe benefit or retirement  plans
which  the  Company  may,  in its sole and  absolute  discretion,  elect to make
available to its employees generally, provided Employee meets the qualifications
therefor.

     (d) Employee  shall be eligible to  participate in the Company's 1998 Long-
Term Incentive Plan (the "Plan") and any other  incentive  plans of the Company.
Upon  the  Employee's  Disability  (as  defined  in the  Plan),  termination  of
employment with the Company due to Retirement (as defined in the Plan) or death,
Employee (or the legal  representative  of his estate, in the case of Employee's
death) shall be entitled to: (i) full vesting and  immediate  exercisability  of
any  outstanding  stock  options  and  other  equity  awards  (and  lapse of any
forfeiture provisions) granted to Employee at any time; and (ii) with respect to
stock options granted to Employee on or after January 1, 2000,  Employee (or the
legal  representative  of his estate,  in the case of Employee's death) shall be
entitled  to exercise  such stock  options at any time during the three (3) year
period from the date of Employee's Disability, Retirement or death.

     (e)  Employee  shall be  entitled to four weeks of paid  vacation  per year
during the Employment Period.

     4. Expenses. Employee shall be entitled to reimbursement for all reasonable
travel and other out-of-pocket  expenses necessarily incurred in the performance
of his duties hereunder,  upon submission and approval of written statements and
bills in accordance with the then regular procedures of the Company.


                                       2

<PAGE>


     5.  Representations  and  Warranties of Employee.  Employee  represents and
warrants  to the  Company  that  Employee  is  under  no  contractual  or  other
restriction  or  obligation  which is  inconsistent  with the  execution of this
Agreement,  the  performance of his duties  hereunder or the other rights of the
Company hereunder.

     6.   Non-Competition.

     (a) In view of the unique and valuable  services that Employee has rendered
or is expected to render to the Company,  Employee's knowledge of the customers,
trade secrets and other proprietary  information relating to the business of the
Company and its  customers and  suppliers  and similar  knowledge  regarding the
Company  which  Employee  has  obtained  or  is  expected  to  obtain,   and  in
consideration  of the  compensation  to be received  hereunder,  Employee agrees
that:

          (i)  during  the  period he is  employed  by the  Company  under  this
     Agreement or otherwise,  he will not Participate In (as hereinafter defined
     in this Section 6) any other business or organization,  whether or not such
     business or  organization  now is or shall then be  competing  with or of a
     nature similar to the business of the Company,  without obtaining the prior
     written consent of the Chief Executive Officer of the Company;

          (ii) until the first  anniversary  of the date of the  termination  of
     Employee's  employment  under  this  Agreement  or  otherwise,  he will not
     Participate  In any business which is engaged,  directly or indirectly,  in
     the same  business as the Company with  respect to any specific  product or
     specific  service  sold or activity in which the Company  engages up to the
     time of termination of employment in any geographical  area in which at the
     time of termination  such product or service is sold or activity is engaged
     in by the Company;

          (iii) if a Change in Control occurs and Employee's employment with the
     Company is terminated  under this Agreement  without Cause (as  hereinafter
     defined) or by Employee  for Good  Reason (as  hereinafter  defined) at any
     time  during the period  beginning  on the date of a Change in Control  and
     ending  one (1) year  after the date of such  Change in  Control  or within
     ninety (90) days prior to a Change in Control,  then beginning on the later
     of the date  Employee's  employment  terminates  (as  described  under this
     Section  6(a)(iii))  and the date of a Change in Control  and ending on the
     second anniversary of such date, he will not Participate In any activity or
     business  in the  United  States  involved  in the  research,  development,
     commercialization  of a small molecule which is: (A) the generic equivalent
     of THALOMID (i.e.,  the same chemical  structure);  (B) an  anti-angiogenic
     agent for oncology use; (C) a  substantially  specific  TNFalpha  inhibitor
     (via inhibition of synthesis of TNFalpha, including via inhibition of PDE4)
     for the treatment of Crohn's disease, rheumatoid arthritis,  dermatological
     and  auto-immune  conditions  having excess levels of TNFalpha as the prime
     causative  factor,  cachexia (AIDS or cancer),  or any other indication for
     which the Company has been


                                       3

<PAGE>


granted orphan drug status; or (D) a formulation of d- or dl-methylphenidate for
the treatment of ADD/ADHD.

     (b) For  purposes of this Section 6 the term  "Participate  In" shall mean:
"directly or  indirectly,  for his own benefit or for, with or through any other
person, firm or corporation,  own, manage,  operate,  control,  loan money to or
participate  in the  ownership,  management,  operation  or  control  of,  or be
connected  as  a  director,  officer,  employee,  partner,  consultant,   agent,
independent  contractor  or otherwise  with, or acquiesce in the use of his name
in."

     (c) Employee  further agrees that,  during the period he is employed by the
Company under this Agreement or otherwise and until the first anniversary of the
date of the  termination  of  Employee's  employment  under  this  Agreement  or
otherwise,  he will not directly or  indirectly  reveal the name of,  solicit or
interfere  with,  or  endeavor  to  entice  away  from the  Company,  any of its
suppliers, customers or employees.

     7. Patents, etc. Any interest in patents, patent applications,  inventions,
technological  innovations,   copyrights,   copyrightable  works,  developments,
discoveries,  designs and processes  ("Inventions")  which  Employee  during the
period he is employed by the Company under this Agreement or otherwise,  and for
six months  thereafter,  may  conceive of or develop and either  relating to the
specific  fields in which the  Company  may then be engaged or  conceived  of or
developed utilizing the time, material, facilities or information of the Company
shall  belong to the Company;  as soon as Employee  conceives of or develops any
Invention,  he agrees  immediately  to  communicate  such fact in writing to the
Secretary of the Company, and without further compensation, but at the Company's
expense  (except  as noted in clause  (a) of this  Section  7),  forthwith  upon
request of the Company,  Employee shall execute all such  assignments  and other
documents  (including  applications  for  patents,  copyrights,  trademarks  and
assignments  thereof)  and  take  all  such  other  action  as the  Company  may
reasonably  request in order (a) to vest in the  Company all  Employee's  right,
title and interest in and to the Inventions, free and clear of liens, mortgages,
security interests,  pledges,  charges and encumbrances arising from the acts of
Employee  ("Liens")  (Employee  to  take  such  action,  at his  expense,  as is
necessary to remove all such Liens) and (b) if patentable or  copyrightable,  to
obtain patents or copyrights (including extensions and renewals) therefor in any
and all countries in such name as the Company shall determine.

     8. Confidential  Information.  All confidential  information which Employee
may now possess, may obtain during or after the Employment Period, or may create
prior  to the  end of the  period  he is  employed  by the  Company  under  this
Agreement  or  otherwise  relating  to the  business  of the  Company  or of any
customer or supplier of the Company  shall not be  published,  disclosed or made
accessible  by him to any other  person,  firm or  corporation  either during or
after  the  termination  of his  employment  or used by him  except  during  the
Employment  Period in the business  and for the benefit of the Company,  in each
case without the prior written permission of the Company.  Employee shall return
all tangible evidence of such  confidential  information to the Company prior to
or  at  the  termination  of  his  employment.   As  used  in  this  Section  8,
"confidential  information"  shall mean any information  except that


                                       4

<PAGE>


information  which  is or comes  into  the  public  domain  through  no fault of
Employee or which  Employee  obtains after the  termination of his employment by
the Company  under this  Agreement or  otherwise  from a third party who has the
right to disclose such information.

     9. Life  Insurance.  If requested by the Company,  Employee shall submit to
such  physical  examinations  and  otherwise  take such  actions and execute and
deliver such documents as may be reasonably  necessary to enable the Company, at
its expense and for its own  benefit,  to obtain life  insurance  on the life of
Employee.  Subject to its  ability to do so under the terms of such  policy,  if
any,  insuring  the  life  of  Employee,  upon  the  termination  of  Employee's
employment hereunder,  the Company will assign to Employee its rights under such
insurance policy,  provided that,  concurrently  with such assignment,  Employee
shall  reimburse  the Company for any  premium  payments  made by the Company in
respect of time periods  subsequent to such date of termination.  Nothing herein
contained shall obligate the Company to obtain such insurance.

     10.  Termination.

     (a) Employee's  employment and the Employment Period shall terminate on the
first of the following to occur:

          (i) the Company  provides  written notice to Employee of a termination
     for Cause;  such written notice shall be provided to Employee not less than
     ten (10) days prior to the date of  termination.  "Cause"  shall mean:  (A)
     Employee's conviction of a crime involving moral turpitude or a felony, (B)
     Employee's acts or omissions taken in bad faith and to the detriment of the
     Company  after a written  demand for cessation of such conduct is delivered
     to Employee by the Company, which demand specifically identifies the manner
     in which the Company believes that Employee has engaged in such conduct and
     the injury to the Company, and after Employee's failure to correct such act
     or omission  within ten (10) days  following  such written  demand,  or (C)
     Employee's  breach of any material  term of this  Agreement  after  written
     demand for substantial performance is delivered to Employee by the Company,
     which  demand  specifically  identifies  the  manner in which  the  Company
     believes Employee has breached this Agreement, and after Employee's failure
     to correct such breach within ten (10) days following such written demand.

          (ii)  Employee's  death, in which case, this Agreement shall terminate
     on the date of Employee's death,  whereupon  Employee or his estate, as the
     case may be,  shall be  entitled to receive a lump sum payment in an amount
     equal to Employee's  annual base salary (at the rate in effect, or required
     to be in effect, immediately prior to the date of Employee's death) and the
     portion of  Employee's  annual  target bonus (as provided in Section  3(b))
     pro-rated  up to  Employee's  date of death  (assuming  the target has been
     met).

          (iii) Nothing contained in this Section 10(a) shall be deemed to limit
     any other  right the Company may have to  terminate  Employee's  employment
     hereunder upon any ground permitted by law.


                                       5

<PAGE>


          (iv) If Employee's employment is terminated by the Company as a result
     of the  disability  or  incapacitation  of Employee or for any reason other
     than pursuant to the  provisions of paragraphs  (i) or (ii) of this Section
     10(a) or the provisions of Section 10(b),  upon  termination by the Company
     of  Employee's   employment,   whether  during  the  Employment  Period  or
     thereafter,  Employee shall be entitled to receive a lump sum payment in an
     amount equal to  Employee's  annual base salary (at the rate in effect,  or
     required  to be in  effect,  immediately  prior to the  date of  Employee's
     termination) and the portion of Employee's annual target bonus (as provided
     in  Section  3(b))   pro-rated  up  to  Employee's   date  of   disability,
     incapacitation or termination (assuming the target has been met).

          (v) In the event of the  Employee's  termination  for any reason under
     this Agreement or otherwise,  the Company shall pay and provide to Employee
     (in  addition  to  any  other  payments  or  benefits  payable  under  this
     Agreement):  (A) any  incurred  but  reimbursed  business  expenses for the
     period prior to the  termination  payable in accordance  with the Company's
     policies;  (B) any base  salary,  bonus,  vacation  pay or  other  deferred
     compensation  accrued  or  earned  under  law  or in  accordance  with  the
     Company's  policies  applicable  to Employee but not yet paid;  and (C) any
     other  amounts  or  benefits  due under  the  terms of the then  applicable
     employee  benefit,  equity or incentive plans of the Company  applicable to
     Employee (the "Accrued Benefits").

          (vi)  Payments of any amounts or benefits  hereunder  shall be made no
     later  than ten (10) days after  Employee's  termination  date,  other than
     benefits under a plan with the terms which do not require or permit payment
     within such ten (10) day period.

     (b) During the ninety (90) day period  prior to Change in Control or during
the one (1) year period  following a Change in Control,  Employee may  terminate
his employment by written notice to the Company within thirty (30) calendar days
after he has obtained actual knowledge of the occurrence of a Good Reason event.
For purposes of this Agreement,  Good Reason shall mean the occurrence of any of
the following events without Employee's express written consent:

          (i) failure to elect or appoint, or reelect or reappoint, Employee to,
     or removal of Employee from, his position with the Company as President and
     Chief Operating  Officer or as a member of the Board,  except in connection
     with the termination of Employee's employment pursuant to Section 10(a);

          (ii) a significant  change in the nature or scope of the  authorities,
     powers,   functions,   duties  or  responsibilities  normally  attached  to
     Employee's position as President and Chief Operating Officer or as a member
     of the Board,  except in each case in connection  with the  termination  of
     Employee's  employment  for Cause or as a result of  Employee's  death,  or
     temporarily as a result of Employee's illness or other absence;

          (iii) a determination by Employee made in good faith that, as a result
     of a  Change  in  Control,  he is  unable  effectively  to  carry  out  the
     authorities,  powers,


                                       6

<PAGE>


     functions, duties or responsibilities attached to his position as President
     and Chief  Operating  Officer or as a member of the Board and the situation
     is not  remedied  within 30 calendar  days after  receipt by the Company of
     written notice from Employee of such determination;

          (iv) a  breach  by the  Company  of any  material  provision  of  this
     Agreement  (not covered by clause (i), (ii) or (iii) of this Section 10(b))
     or of any other  agreement,  which is not remedied  within 30 calendar days
     after  receipt by the  Company  of written  notice  from  Employee  of such
     breach;

          (v) a reduction in Employee's annual base salary;

          (vi) a  fifty  (50)  mile  or  greater  relocation  of  the  Company's
     principal office;

          (vii)  failure  of the  Company  to  continue  in effect any health or
     welfare plan,  employee benefit plan,  pension plan, fringe benefit plan or
     compensation   plan  in  which  Employee  (and  eligible   dependents)  are
     participating  immediately  prior to a Change in Control,  unless  Employee
     (and  eligible  dependents)  are  permitted to  participate  in other plans
     providing Employee (and eligible dependents) with substantially  comparable
     benefits  at  no  greater   after-tax   cost  to  Employee   (and  eligible
     dependents),  or the  taking  of any  action  by the  Company  which  would
     adversely affect the Employee's (and eligible dependents)  participation in
     or reduce  Employee's  (and eligible  dependents)  benefits  under any such
     plan; or

          (viii) failure of a successor to assume this Agreement.

     An election by Employee to terminate his employment under the provisions of
this Section 10(b) shall not  constitute a breach by Employee of this  Agreement
and shall not be deemed a voluntary  termination  of  employment by Employee for
the purpose of  interpreting  the  provisions of any of the  Company's  employee
benefit plans, programs or policies.

     (c) Upon the  occurrence  of a Change in  Control  and  thereafter:  (A) if
Employee's  employment  with the Company is  terminated  by the Company  without
Cause or as a result of the  disability  or  incapacitation  of Employee,  or by
Employee with Good Reason at any time during the period beginning on the date of
the Change in Control  and ending one (1) year after the date of such  Change in
Control,  or (B) if Employee's  employment with the Company is terminated by the
Company  without  Cause or by Employee for Good Reason  within  ninety (90) days
prior to the occurrence of a Change in Control,  then Employee shall be entitled
to receive from the Company:

          (i) a lump sum  amount,  payable  within  ten  (10)  days  after  such
     termination (or, if such termination occurred prior to a Change in Control,
     within ten (10) days after the  Change in  Control)  equal to (A) three (3)
     times  Employee's  base  salary in  effect,  or  required  to be in effect,
     immediately  prior to the  Change in  Control,


                                       7

<PAGE>


     and (B) three (3)  times  the  highest  annual  bonus  paid or  payable  to
     Employee within three (3) years prior to the Change in Control;

          (ii)  within  ten  (10)  days  after  such  termination  (or,  if such
     termination  occurred  prior to a Change in  Control,  within ten (10) days
     after the Change in Control) equal to the Accrued Benefits;

          (iii)  payment by the Company of the premiums for Employee  (except in
     the case of Employee's  death) and  Employee's and  dependents'  health and
     welfare coverage  (including,  without  limitation,  medical,  dental, life
     insurance  and  disability  coverage) for three (3) years from the later of
     the  occurrence  of a  Change  in  Control  or the date of  termination  of
     Employee's  employment,  under the Company's health and welfare plans which
     cover the senior  executives of the Company or materially  similar benefits
     ("Continuation  Coverage"),  subject to  Employee's  payment  of  customary
     premiums (if any) in effect prior to the Change in Control;

          (iv) upon the  occurrence  of a Change in Control,  full and immediate
     vesting of all stock options and equity awards held by Employee.

     Payments under (iii) above may, at the  discretion of the Company,  be made
by continuing Employee's  participation in the plan as a terminee or by covering
Employee and Employee's dependents under substitute arrangements, provided that,
notwithstanding  anything herein to the contrary,  to the extent Employee incurs
tax that Employee  would not have incurred as an active  employee as a result of
the aforementioned coverage or the benefits provided thereunder,  Employee shall
receive  from the  Company  an  additional  grossed  up  payment  in the  amount
necessary so that Employee will have no additional cost for receiving such items
or any  additional  payment.  Notwithstanding  anything  herein to the contrary,
Employee  (and his  eligible  dependents)  shall  retain  all  rights  under the
Consolidated Omnibus Budget Reconciliation Act of 1985, as amended ("COBRA") and
such  COBRA  continuation  coverage  shall be  available  to  Employee  (and his
eligible  dependents) at the expiration of the Continuation  Coverage  described
herein.

     (d) For  purposes  of this  Agreement,  a Change in Control  shall mean the
occurrence of the following:

          (i) any person  (as  defined  in  Section  3(a)(9)  of the  Securities
     Exchange  Act of 1934,  as  amended  (the  "Exchange  Act")  and as used in
     Sections 13(d) and 14(d) thereof), excluding the Company, any subsidiary of
     the Company and any employee  benefit plan  sponsored or  maintained by the
     Company or any subsidiary of the Company (including any trustee of any such
     plan acting in his capacity as trustee),  becoming the  "beneficial  owner"
     (as  defined in Rule 13d-3 under the  Exchange  Act) of  securities  of the
     Company  representing  thirty  percent (30%) of the total  combined  voting
     power of the Company's then outstanding securities;


                                       8

<PAGE>


          (ii) the merger,  consolidation  or other business  combination of the
     Company (a "Transaction"),  other than (A) a Transaction involving only the
     Company  and  one  or  more  of  its  subsidiaries,  or  (B) a  Transaction
     immediately  following which the  stockholders  of the Company  immediately
     prior to the Transaction continue to have a majority of the voting power in
     the  resulting  entity  and no person  (other  than  those  covered  by the
     exceptions in (a) above) becomes the beneficial  owner of securities of the
     resulting entity  representing  more than twenty-five  percent (25%) of the
     voting power in the resulting entity;

          (iii) during any period of two (2)  consecutive  years beginning on or
     after  the  date  hereof,  the  persons  who  were  members  of  the  Board
     immediately before the beginning of such period (the "Incumbent Directors")
     ceasing (for any reason other than death) to constitute at least a majority
     of the Board or the board of  directors  of any  successor  to the Company,
     provided  that,  any  director who was not a director as of the date hereof
     shall be deemed to be an Incumbent Director if such director was elected to
     the board of directors by, or on the recommendation of or with the approval
     of, at least  two-thirds of the  directors who then  qualified as Incumbent
     Directors  either  actually or by prior  operation of the foregoing  unless
     such election,  recommendation  or approval occurs as a result of an actual
     or threatened  election  contest (as such terms are used in Rule 14a- 11 of
     Regulation  14A  promulgated  under  the  Exchange  Act  or  any  successor
     provision)  or other  actual  or  threatened  solicitation  of  proxies  or
     contests by or on behalf of a person other than a member of the Board; or

          (iv) the  approval by the  stockholders  of the Company of any plan of
     complete  liquidation of the Company or an agreement for the sale of all or
     substantially  all of the  Company's  assets  other than the sale of all or
     substantially  all of the assets of the  Company to a person or persons who
     beneficially own,  directly or indirectly,  at least fifty percent (50%) or
     more of the combined voting power of the outstanding  voting  securities of
     the Company at the time of such sale.

          (v) To the extent that  Employee is entitled to payment  under Section
     10(c) upon a Change in Control due to Employee's  termination without Cause
     or for Good  Reason  within  ninety (90) days prior to a Change in Control,
     any such payments under Section 10(c) shall be reduced by any payments made
     to  Employee  prior to a Change in Control  under  Sections  10(a)(iv)  and
     10(a)(v).

     11.  Limitation on Payments.

     (a) In the event that Employee shall become entitled to the payments and/or
benefits provided by Section 10(c) or any other amounts (whether pursuant to the
terms of this  Agreement or any other plan,  arrangement  or agreement  with the
Company,  any person whose  actions  result in a change of ownership  covered by
Section 280G(b)(2) of the Internal Revenue Code of 1986, as amended (the "Code")
or any  person  affiliated  with the  Company  or such  person) as a result of a
Change of  Control  (collectively  the  "Company  Payments"),  and such  Company
Payments  will be subject to the tax (the "Excise  Tax") imposed by Section 4999
of


                                       9

<PAGE>


the Code (and any similar tax that may  hereafter be imposed) the Company  shall
pay to Employee at the time  specified  in  subsection  (d) below an  additional
amount (the "Gross-up  Payment") such that the net amount  retained by Employee,
after  deduction  of any Excise Tax on the  Company  Payments  and any  federal,
state,  and local income or payroll tax upon the Gross-up  Payment pro vided for
by this paragraph (a), but before  deduction for any federal,  state,  and local
income or payroll  tax on the  Company  Payments,  shall be equal to the Company
Payments.  Notwithstanding  the  foregoing  provisions of this Section 11 to the
contrary,  if it shall be  determined  that  Employee  is entitled to a Gross-up
Payment,  but the Company Payments do not exceed one hundred five percent (105%)
of the greatest  amount that could be paid to Employee  such that the receipt of
Company  Payments would not give rise to any Excise Tax (the "Reduced  Amount"),
then no Gross-up Payment shall be made to Employee and the Company Payments,  in
the aggregate, shall be reduced to the Reduced Amount.

     (b) For  purposes of  determining  whether any of the Company  Payments and
Gross-up  Payments  (collectively  the "Total  Payments") will be subject to the
Excise Tax and determining the amount of such Excise Tax: (i) the Total Payments
shall  be  treated  as  "parachute  payments"  within  the  meaning  of  Section
280G(b)(2)  of the Code,  and all  "parachute  payments"  in excess of the "base
amount" (as defined under Code Section  280G(b)(3) of the Code) shall be treated
as subject  to the Excise  Tax,  unless  and except to the extent  that,  in the
opinion of the Company's  independent  certified  public  accountants  appointed
prior to any change in ownership (as defined under Code Section  280G(b)(2))  or
tax counsel selected by such accountants (the "Accountants") such Total Payments
(in whole or in part), (A) do not constitute "parachute payments," (B) represent
reasonable  compensation  for services  actually  rendered within the meaning of
Section  280G(b)(4)  of the Code" or (C) are otherwise not subject to the Excise
Tax;  and (ii) the value of any  non-cash  benefits or any  deferred  payment or
benefit shall be determined by the Accountants in accordance with the principles
of Section 280G of the Code.

     (c) For  purposes  of  determining  the  amount  of the  Gross-up  Payment,
Employee  shall be deemed to pay federal  income  taxes at the highest  marginal
rate of federal  income  taxation  in the  calendar  year in which the  Gross-up
Payment is to be made and state and local income  taxes at the highest  marginal
rate of  taxation  in the state and  locality of  Employee's  residence  for the
calendar  year in which the  Company  Payment is to be made,  net of the maximum
reduction in federal income taxes which could be obtained from deduction of such
state and local taxes if paid in such year.  In the event that the Excise Tax is
subsequently determined by the Accountants to be less than the amount taken into
account hereunder at the time the Gross-up Payment is made, Employee shall repay
to the Company,  at the time that the amount of such  reduction in Excise Tax is
finally  determined,  the portion of the prior Gross-up Payment  attributable to
such reduction  (plus the portion of the Gross-up  Payment  attributable  to the
Excise Tax and federal, state and local income tax imposed on the portion of the
Gross-up  Payment  being  repaid by  Employee  if such  repayment  results  in a
reduction  in Excise Tax or a federal,  state and local  income tax  deduction),
plus  interest on the amount of such  repayment at the rate  provided in Section
1274(b)(2)(B)  of the  Code.  Notwithstanding  the  foregoing,  in the event any
portion of the  Gross-up  Payment to be refunded to the Company has been paid to
any  federal,  state and local tax  authority,  repayment  thereof  (and related
amounts) shall not be


                                       10

<PAGE>


required  until  actual  refund  or  credit  of such  portion  has been  made to
Employee,  and  interest  payable to the Company  shall not exceed the  interest
received or credited  to Employee by such tax  authority  for the period it held
such portion.  Employee and the Company shall  mutually agree upon the course of
action to be pursued  (and the method of  allocating  the  expense  thereof)  if
Employee's claim for refund or credit is denied.

     In the event that the Excise Tax is later  determined by the Accountants or
the Internal  Revenue Service to exceed the amount taken into account  hereunder
at the time the Gross-up Payment is made (including by reason of any payment the
existence  or amount of which cannot be  determined  at the time of the Gross-up
Payment),  the Company shall make an additional  Gross-up  Payment in respect of
such excess (plus any interest or penalties payable with respect to such excess)
at the time that the amount of such excess is finally determined.

     (d) The Gross-up  Payment or portion thereof provided for in subsection (c)
above shall be paid not later than the  thirtieth  (30th) day following an event
occurring which sub jects Employee to the Excise Tax; provided, however, that if
the  amount of such  Gross-up  Payment  or  portion  thereof  cannot be  finally
determined  on or before such day, the Company shall pay to Employee on such day
an estimate,  as  determined  in good faith by the  Accountants,  of the minimum
amount of such payments and shall pay the  remainder of such payments  (together
with interest at the rate provided in Code Section  1274(b)(2)(B)  of the Code),
subject to further  payments  pursuant to subsection (c) hereof,  as soon as the
amount  thereof can  reasonably  be  determined,  but in no event later than the
ninetieth  (90th) day after the occurrence of the event  subjecting  Employee to
the Excise Tax. In the event that the amount of the estimated  payments  exceeds
the  amount  subsequently  determined  to  have  been  due,  such  excess  shall
constitute  a loan by the  Company to  Employee,  payable on the fifth (5th) day
after  demand by the Company  (together  with  interest at the rate  provided in
Section 1274(b)(2)(B) of the Code).

     (e) In the event of any controversy  with the Internal  Revenue Service (or
other taxing authority) under this Section 11, Employee shall permit the Company
to control  issues  related to this Section 11 (at its  expense),  provided that
such  issues  do not  potentially  materially  adversely  affect  Employee,  but
Employee  shall  control  any  other  issues.   In  the  event  the  issues  are
interrelated,  Employee and the Company shall in good faith  cooperate so as not
to  jeopardize  resolution  of either  issue,  but if the parties  cannot agree,
Employee shall make the final  determination  with regard to the issues.  In the
event of any  conference  with any  taxing  authority  as to the  Excise  Tax or
associated income taxes, Employee shall permit the representative of the Company
to accompany him, and Employee and his  representative  shall cooperate with the
Company and its representative.

     (f) The Company shall be responsible for all charges of the Accountants.

     12.  Successors.  In  addition to any  obligations  imposed by law upon any
successor to the Company, the Company will require any successor (whether direct
or  indirect,  by  purchase,  merger,  consolidation  or  otherwise)  to  all or
substantially  all of the  business  and/or  assets of the Company to  expressly
assume and agree in writing to perform this


                                       11

<PAGE>


Agreement  in the same manner and to the same  extent that the Company  would be
required to perform it if no such succession had taken place.

     13. Survival.  The covenants,  agreements,  representations  and warranties
contained  in or  made  pursuant  to this  Agreement  shall  survive  Employee's
termination of employment.

     14. Entire  Agreement;  Modification.  This Agreement sets forth the entire
understanding  of the  parties  with  respect  to  the  subject  matter  hereof,
supersedes all existing  agreements  between them concerning such subject matter
(including,  without limitation, the employment agreement in effect prior to the
date hereof) and may be modified only by a written  instrument  duly executed by
each party.

     15. Notices. Any notice or other communication  required or permitted to be
given  hereunder  shall be in  writing  and shall be mailed by  certified  mail,
return receipt  requested,  or delivered against receipt to the party to whom it
is to be given at the  address of such party set forth in the  preamble  to this
Agreement (or to such other address as the party shall have furnished in writing
in accordance  with the provisions of this Section 15).  Notice to the estate of
Employee  shall be  sufficient  if  addressed  to  Employee  as provided in this
Section 15. Any notice or other  communication  given by certified mail shall be
deemed given three days after the time of  certification  thereof,  except for a
notice  changing a party's  address  which shall be deemed  given at the time of
receipt thereof.

     16. Waiver. Any waiver by either party of a breach of any provision of this
Agreement  shall  not  operate  as or be  construed  to be a waiver of any other
breach  of such  provision  or of any  breach  of any  other  provision  of this
Agreement. The failure of a party to insist upon strict adherence to any term of
this  Agreement  on one or more  occasions  shall not be  considered a waiver or
deprive that party of the right  thereafter  to insist upon strict  adherence to
that term or any other term of this  Agreement.  Any waiver  must be in writing,
signed by the party giving such waiver.

     17. Binding Effect.  Employee's rights and obligations under this Agreement
shall not be transferable  by assignment or otherwise,  such rights shall not be
subject to commutation,  encumbrance or the claims of Employee's creditors,  and
any attempt to do any of the  foregoing  shall be void.  The  provisions of this
Agreement  shall be binding  upon and inure to the benefit of  Employee  and his
heirs and personal  representatives,  and shall be binding upon and inure to the
benefit of the Company and its successors and its assigns under Section 12.

     18. No Third Party Beneficiaries. This Agreement does not create, and shall
not be construed as creating,  any rights  enforceable by any person not a party
to this Agreement (except as provided in Sections 12 and 17).

     19. Legal Fees. To the fullest  extent  permitted by law, the Company shall
promptly pay upon  submission  of  statements  all legal and other  professional
fees, costs of litigation,  prejudgment interest, and other expenses incurred in
connection with any dispute


                                       12

<PAGE>


concerning payments,  benefits and other entitlements to which Employee may have
under this  Agreement;  provided,  however,  the Company  shall be reimbursed by
Employee for the fees and expenses advanced in the event Employee's claim is, in
a material  manner,  in bad faith or frivolous and the  arbitrator or court,  as
applicable,  determines  that the  reimbursement  of such fees and  expenses  is
appropriate.

     20.  Pooling of  Interests;  Severability.  In the event that the Company's
independent  public  accountants  determine in good faith that any  provision of
this  Agreement  would preclude  "pooling of interests"  accounting and provided
that the Company engages in a transaction  which utilizes "pooling of interests"
accounting, such provision shall be deemed invalid and inoperative solely to the
extent necessary to permit "pooling of interests"  transactions.  If any portion
of this Agreement is held invalid or inoperative  (including a determination  by
the Company's independent public accountants in good faith that any provision of
this Agreement  would  preclude  "pooling of interests"  accounting),  the other
provisions of this  Agreement  shall be deemed to be valid and operative and, so
far as is  reasonable  and  possible,  effect  shall  be  given  to  the  intent
manifested by the portion held valid or inoperative.

     21. No Duty to  Mitigate/No  Offset.  The Company agrees that if Employee's
employment with the Company is terminated  pursuant to this Agreement during the
term of this Agreement,  Employee shall not be required to seek other employment
or to attempt  in any way to reduce  any  amounts  payable  to  Employee  by the
Company  pursuant  to this  Agreement.  Further,  the  amount of any  payment or
benefit  provided for in this Agreement shall not be reduced by any compensation
earned by Employee or benefit  provided to Employee as the result of  employment
by another employer or otherwise. The Company's obligations to make the payments
provided  for in  this  Agreement  and  otherwise  to  perform  its  obligations
hereunder  shall  not  be  affected  by  any  circumstances,  including  without
limitation, any set-off, counterclaim,  recoupment, defense or other right which
the Company may have against Employee.  Notwithstanding the foregoing,  payments
and benefits  under the  Agreement  will cease to be paid and may be recouped by
the Company in the event Employee breaches any of the terms of Section 6, 7 or 8
hereunder.

     22.  Counterparts;  Governing  Law.  This  Agreement may be executed in any
number of  counterparts,  each of which shall be deemed an original,  but all of
which  together  shall  constitute  one and the  same  instrument.  It  shall be
governed  by and  construed  in  accordance  with the  laws of the  State of New
Jersey, without giving effect to the conflict of laws.


                                       13

<PAGE>


     IN WITNESS WHEREOF, the parties have duly executed this Agreement as of the
date first above written.

                                               CELGENE CORPORATION


                                                By:
                                                   -----------------------------
                                                     Richard C. E. Morgan
                                                     Chairman of the
                                                     Compensation Committee


                                                By:
                                                   -----------------------------
                                                     John W. Jackson
                                                     Chief Executive Officer




                                                --------------------------------
                                                     Sol J. Barer



                                       13




                                                                   EXHIBIT 10.18

                              EMPLOYMENT AGREEMENT

     EMPLOYMENT  AGREEMENT  (this  "Agreement"),  dated as of  January  1, 2000,
between Celgene  Corporation,  a Delaware  corporation  with offices at 7 Powder
Horn  Drive,  Warren,  New Jersey  07059 (the  "Company"),  and Robert J. Hugin,
residing at 58 Ox Bow Lane, Summit, New Jersey 07901 ("Employee").

                               W I T N E S S E T H
                               - - - - - - - - - -

     WHEREAS, Employee is currently employed by the Company;

     WHEREAS,  the  Company  desires  that  Employee  be  employed  in a  senior
executive  capacity with the Company subject to the terms and conditions hereof,
and Employee desires to be employed by the Company in such capacity; and

     WHEREAS,  the parties  hereto  desire to set forth in writing the terms and
conditions of their  understandings and agreements and to supersede any existing
agreement between the parties.

     NOW  THEREFORE,  in  consideration  of the  premises  and mutual  covenants
contained  herein and for other good and  valuable  consideration,  the  parties
agree as follows:

     1. Term.  The Company  agrees to employ  Employee,  and Employee  agrees to
serve, on the terms and conditions of this Agreement for a period  commencing on
the date  hereof and ending  three  years  from the date  hereof,  or such other
period as may be  provided  for in Section 10 or 11.  The  period  during  which
Employee is employed  hereunder is  hereinafter  referred to as the  "Employment
Period." The  Employment  Period shall be  automatically  renewed for successive
one- year terms unless either party gives  written  notice to the other at least
six (6) months prior to the expiration of the then  Employment  Period,  of such
party's intention to terminate Employee's employment hereunder at the end of the
then current Employment Period.

     2. Duties and Services.  During the  Employment  Period,  Employee shall be
employed  in the  business of the  Company as Senior  Vice  President  and Chief
Financial Officer of the Company. In addition, Employee shall serve as Secretary
to the Board.  Employee  shall  perform  such  duties and  services,  within his
expertise  and  experience,  as may be  assigned  to him by, and  subject to the
direction of, the Chief Executive Officer and the Board.  Employee agrees to his
employment  as  described  in this  Section 2 and  agrees  to devote  all of his
working time and efforts to the  performance of his duties under this Agreement,
excepting  disabilities,  illness and vacation time as provided by Section 3(e).
In performing his duties  hereunder,  Employee shall be available for reasonable
travel as the needs of the  business  require.  Except as  provided in Section 6
hereof,  the foregoing  shall not be construed as preventing  Employee from: (i)
making  investments  in  other  businesses  and  managing  his and his  family's
personal investments; and (ii) participating in charitable,  civic, educational,
professional, community or industry affairs or


<PAGE>


serving  on  the  board  of   directors   of  other   companies   ("Professional
Activities"),  provided that these  Professional  Activities are approved by the
Company's Board.

     3.   Compensation and Other Benefits.

     (a) As  compensation  for his  services  hereunder,  the Company  shall pay
Employee,  during  the  Employment  Period,  a  base  salary  payable  in  equal
semi-monthly  installments  at an annual rate of  $240,000,  provided  that such
salary  shall be  reviewed  annually  by the  Company's  Board,  or a  committee
thereof,  which may, in its sole  discretion,  increase (but not decrease)  such
salary.

     (b) The Company shall also pay Employee,  during the Employment  Period, an
annual target bonus,  payable in January of each year for the preceding year, in
an amount equal to thirty-five  percent (35%) of Employee's base salary (payable
under Section 3(a) of this Agreement)  measured against objective criteria to be
determined  by the Company's  Board,  or a committee  thereof,  after good faith
consultation with Employee.

     (c)  Employee  shall be entitled  to  participate  in all group  health and
insurance  programs and all other fringe  benefit or retirement  plans which the
Company may, in its sole and absolute discretion, elect to make available to its
employees generally, provided Employee meets the qualifications therefor.

     (d)  Employee  shall be  eligible  to  participate  in the  Company's  1998
Long-Term  Incentive  Plan (the  "Plan")  and any other  incentive  plans of the
Company. Upon the Employee's Disability (as defined in the Plan), termination of
employment with the Company due to Retirement (as defined in the Plan) or death,
Employee (or the legal  representative  of his estate, in the case of Employee's
death) shall be entitled to: (i) full vesting and  immediate  exercisability  of
any  outstanding  stock  options  and  other  equity  awards  (and  lapse of any
forfeiture provisions) granted to Employee at any time; and (ii) with respect to
stock options granted to Employee on or after January 1, 2000,  Employee (or the
legal  representative  of his estate,  in the case of Employee's death) shall be
entitled  to exercise  such stock  options at any time during the three (3) year
period from the date of Employee's Disability, Retirement or death.

     (e)  Employee  shall be  entitled to four weeks of paid  vacation  per year
during the Employment Period.

     4. Expenses. Employee shall be entitled to reimbursement for all reasonable
travel and other out-of-pocket  expenses necessarily incurred in the performance
of his duties hereunder,  upon submission and approval of written statements and
bills in accordance with the then regular procedures of the Company.

     5.  Representations  and  Warranties of Employee.  Employee  represents and
warrants  to the  Company  that  Employee  is  under  no  contractual  or  other
restriction  or  obligation  which is  inconsistent  with the  execution of this
Agreement,  the  performance of his duties  hereunder or the other rights of the
Company hereunder.


                                        2

<PAGE>


     6.   Non-Competition.

     (a) In view of the unique and valuable  services that Employee has rendered
or is expected to render to the Company,  Employee's knowledge of the customers,
trade secrets and other proprietary  information relating to the business of the
Company and its  customers and  suppliers  and similar  knowledge  regarding the
Company  which  Employee  has  obtained  or  is  expected  to  obtain,   and  in
consideration  of the  compensation  to be received  hereunder,  Employee agrees
that:

          (i)  during  the  period he is  employed  by the  Company  under  this
     Agreement or otherwise,  he will not Participate In (as hereinafter defined
     in this Section 6) any other business or organization,  whether or not such
     business or  organization  now is or shall then be  competing  with or of a
     nature similar to the business of the Company,  without obtaining the prior
     written consent of the Chief Executive Officer of the Company;

          (ii) until the first  anniversary  of the date of the  termination  of
     Employee's  employment  under  this  Agreement  or  otherwise,  he will not
     Participate  In any business which is engaged,  directly or indirectly,  in
     the same  business as the Company with  respect to any specific  product or
     specific  service  sold or activity in which the Company  engages up to the
     time of termination of employment in any geographical  area in which at the
     time of termination  such product or service is sold or activity is engaged
     in by the Company;

          (iii) if a Change in Control occurs and Employee's employment with the
     Company is terminated  under this Agreement  without Cause (as  hereinafter
     defined) or by Employee  for Good  Reason (as  hereinafter  defined) at any
     time  during the period  beginning  on the date of a Change in Control  and
     ending  one (1) year  after the date of such  Change in  Control  or within
     ninety (90) days prior to a Change in Control,  then beginning on the later
     of the date  Employee's  employment  terminates  (as  described  under this
     Section  6(a)(iii))  and the date of a Change in Control  and ending on the
     second anniversary of such date, he will not Participate In any activity or
     business  in the  United  States  involved  in the  research,  development,
     commercialization  of a small molecule which is: (A) the generic equivalent
     of THALOMID (i.e.,  the same chemical  structure);  (B) an  anti-angiogenic
     agent for oncology use; (C) a  substantially  specific  TNFalpha  inhibitor
     (via inhibition of synthesis of TNFalpha, including via inhibition of PDE4)
     for the treatment of Crohn's disease, rheumatoid arthritis,  dermatological
     and  auto-immune  conditions  having excess levels of TNFalpha as the prime
     causative  factor,  cachexia (AIDS or cancer),  or any other indication for
     which the Company has been granted orphan drug status; or (D) a formulation
     of d- or dl-methylphenidate for the treatment of ADD/ADHD.

     (b) For  purposes of this Section 6 the term  "Participate  In" shall mean:
"directly or  indirectly,  for his own benefit or for, with or through any other
person, firm or corporation,  own, manage,  operate,  control,  loan money to or
participate  in the  ownership,  management,  operation  or  control  of,  or be
connected  as  a  director,  officer,  employee,  partner,  consultant,   agent,
independent  contractor  or otherwise  with, or acquiesce in the use of his name
in."


                                        3

<PAGE>


     (c) Employee  further agrees that,  during the period he is employed by the
Company under this Agreement or otherwise and until the first anniversary of the
date of the  termination  of  Employee's  employment  under  this  Agreement  or
otherwise,  he will not directly or  indirectly  reveal the name of,  solicit or
interfere  with,  or  endeavor  to  entice  away  from the  Company,  any of its
suppliers, customers or employees.

     7. Patents, etc. Any interest in patents, patent applications,  inventions,
technological  innovations,   copyrights,   copyrightable  works,  developments,
discoveries,  designs and processes  ("Inventions")  which  Employee  during the
period he is employed by the Company under this Agreement or otherwise,  and for
six months  thereafter,  may  conceive of or develop and either  relating to the
specific  fields in which the  Company  may then be engaged or  conceived  of or
developed utilizing the time, material, facilities or information of the Company
shall  belong to the Company;  as soon as Employee  conceives of or develops any
Invention,  he agrees  immediately  to  communicate  such fact in writing to the
Secretary of the Company, and without further compensation, but at the Company's
expense  (except  as noted in clause  (a) of this  Section  7),  forthwith  upon
request of the Company,  Employee shall execute all such  assignments  and other
documents  (including  applications  for  patents,  copyrights,  trademarks  and
assignments  thereof)  and  take  all  such  other  action  as the  Company  may
reasonably  request in order (a) to vest in the  Company all  Employee's  right,
title and interest in and to the Inventions, free and clear of liens, mortgages,
security interests,  pledges,  charges and encumbrances arising from the acts of
Employee  ("Liens")  (Employee  to  take  such  action,  at his  expense,  as is
necessary to remove all such Liens) and (b) if patentable or  copyrightable,  to
obtain patents or copyrights (including extensions and renewals) therefor in any
and all countries in such name as the Company shall determine.

     8. Confidential  Information.  All confidential  information which Employee
may now possess, may obtain during or after the Employment Period, or may create
prior  to the  end of the  period  he is  employed  by the  Company  under  this
Agreement  or  otherwise  relating  to the  business  of the  Company  or of any
customer or supplier of the Company  shall not be  published,  disclosed or made
accessible  by him to any other  person,  firm or  corporation  either during or
after  the  termination  of his  employment  or used by him  except  during  the
Employment  Period in the business  and for the benefit of the Company,  in each
case without the prior written permission of the Company.  Employee shall return
all tangible evidence of such  confidential  information to the Company prior to
or  at  the  termination  of  his  employment.   As  used  in  this  Section  8,
"confidential  information"  shall mean any information  except that information
which is or comes into the public  domain  through no fault of Employee or which
Employee  obtains after the  termination  of his employment by the Company under
this  Agreement  or  otherwise  from a third party who has the right to disclose
such information.

     9. Life  Insurance.  If requested by the Company,  Employee shall submit to
such  physical  examinations  and  otherwise  take such  actions and execute and
deliver such documents as may be reasonably  necessary to enable the Company, at
its expense and for its own  benefit,  to obtain life  insurance  on the life of
Employee.  Subject to its  ability to do so under the terms of such  policy,  if
any,  insuring  the  life  of  Employee,  upon  the  termination  of  Employee's
employment hereunder,  the Company will assign to Employee its rights under such
insurance policy,  provided


                                        4

<PAGE>


that,  concurrently  with such assignment,  Employee shall reimburse the Company
for any  premium  payments  made  by the  Company  in  respect  of time  periods
subsequent to such date of termination.  Nothing herein contained shall obligate
the Company to obtain such insurance.

     10.  Termination.

     (a) Employee's  employment and the Employment Period shall terminate on the
first of the following to occur:

          (i) the Company  provides  written notice to Employee of a termination
     for Cause;  such written notice shall be provided to Employee not less than
     ten (10) days prior to the date of  termination.  "Cause"  shall mean:  (A)
     Employee's conviction of a crime involving moral turpitude or a felony, (B)
     Employee's acts or omissions taken in bad faith and to the detriment of the
     Company  after a written  demand for cessation of such conduct is delivered
     to Employee by the Company, which demand specifically identifies the manner
     in which the Company believes that Employee has engaged in such conduct and
     the injury to the Company, and after Employee's failure to correct such act
     or omission  within ten (10) days  following  such written  demand,  or (C)
     Employee's  breach of any material  term of this  Agreement  after  written
     demand for substantial performance is delivered to Employee by the Company,
     which  demand  specifically  identifies  the  manner in which  the  Company
     believes Employee has breached this Agreement, and after Employee's failure
     to correct such breach within ten (10) days following such written demand.

          (ii)  Employee's  death, in which case, this Agreement shall terminate
     on the date of Employee's death,  whereupon  Employee or his estate, as the
     case may be,  shall be  entitled to receive a lump sum payment in an amount
     equal to Employee's  annual base salary (at the rate in effect, or required
     to be in effect, immediately prior to the date of Employee's death) and the
     portion of  Employee's  annual  target bonus (as provided in Section  3(b))
     pro-rated  up to  Employee's  date of death  (assuming  the target has been
     met).

          (iii) Nothing contained in this Section 10(a) shall be deemed to limit
     any other  right the Company may have to  terminate  Employee's  employment
     hereunder upon any ground permitted by law.

          (iv) If Employee's employment is terminated by the Company as a result
     of the  disability  or  incapacitation  of Employee or for any reason other
     than pursuant to the  provisions of paragraphs  (i) or (ii) of this Section
     10(a) or the provisions of Section 10(b),  upon  termination by the Company
     of  Employee's   employment,   whether  during  the  Employment  Period  or
     thereafter,  Employee shall be entitled to receive a lump sum payment in an
     amount equal to  Employee's  annual base salary (at the rate in effect,  or
     required  to be in  effect,  immediately  prior to the  date of  Employee's
     termination) and the portion of Employee's annual target bonus (as provided
     in  Section  3(b))   pro-rated  up  to  Employee's   date  of   disability,
     incapacitation or termination (assuming the target has been met).

          (v) In the event of the  Employee's  termination  for any reason under
     this Agreement or otherwise,  the Company shall pay and provide to Employee
     (in  addition  to


                                        5

<PAGE>


     any other  payments  or benefits  payable  under this  Agreement):  (A) any
     incurred  but  reimbursed  business  expenses  for the period  prior to the
     termination payable in accordance with the Company's policies; (B) any base
     salary,  bonus,  vacation  pay or other  deferred  compensation  accrued or
     earned under law or in accordance with the Company's policies applicable to
     Employee but not yet paid;  and (C) any other amounts or benefits due under
     the terms of the then  applicable  employee  benefit,  equity or  incentive
     plans of the Company applicable to Employee (the "Accrued Benefits").

          (vi)  Payments of any amounts or benefits  hereunder  shall be made no
     later  than ten (10) days after  Employee's  termination  date,  other than
     benefits under a plan with the terms which do not require or permit payment
     within such ten (10) day period.

     (b) During the ninety (90) day period  prior to Change in Control or during
the one (1) year period  following a Change in Control,  Employee may  terminate
his employment by written notice to the Company within thirty (30) calendar days
after he has obtained actual knowledge of the occurrence of a Good Reason event.
For purposes of this Agreement,  Good Reason shall mean the occurrence of any of
the following events without Employee's express written consent:

          (i) failure to elect or appoint, or reelect or reappoint, Employee to,
     or removal of Employee  from,  his position with the Company as Senior Vice
     President and Chief Financial Officer or as Secretary to the Board,  except
     in connection  with the  termination of Employee's  employment  pursuant to
     Section 10(a);

          (ii) a significant  change in the nature or scope of the  authorities,
     powers,   functions,   duties  or  responsibilities  normally  attached  to
     Employee's position as Senior Vice President and Chief Financial Officer or
     as  Secretary  to the  Board,  except in each case in  connection  with the
     termination of Employee's employment for Cause or as a result of Employee's
     death, or temporarily as a result of Employee's illness or other absence;

          (iii) a determination by Employee made in good faith that, as a result
     of a  Change  in  Control,  he is  unable  effectively  to  carry  out  the
     authorities,  powers, functions, duties or responsibilities attached to his
     position  as Senior  Vice  President  and  Chief  Financial  Officer  or as
     Secretary to the Board and the situation is not remedied within 30 calendar
     days after  receipt by the Company of written  notice from Employee of such
     determination;

          (iv) a  breach  by the  Company  of any  material  provision  of  this
     Agreement  (not covered by clause (i), (ii) or (iii) of this Section 10(b))
     or of any other  agreement,  which is not remedied  within 30 calendar days
     after  receipt by the  Company  of written  notice  from  Employee  of such
     breach;

          (v) a reduction in Employee's annual base salary;


                                        6

<PAGE>


          (vi) a  fifty  (50)  mile  or  greater  relocation  of  the  Company's
     principal office;

          (vii)  failure  of the  Company  to  continue  in effect any health or
     welfare plan,  employee benefit plan,  pension plan, fringe benefit plan or
     compensation   plan  in  which  Employee  (and  eligible   dependents)  are
     participating  immediately  prior to a Change in Control,  unless  Employee
     (and  eligible  dependents)  are  permitted to  participate  in other plans
     providing Employee (and eligible dependents) with substantially  comparable
     benefits  at  no  greater   after-tax   cost  to  Employee   (and  eligible
     dependents),  or the  taking  of any  action  by the  Company  which  would
     adversely affect the Employee's (and eligible dependents)  participation in
     or reduce  Employee's  (and eligible  dependents)  benefits  under any such
     plan; or

          (viii) failure of a successor to assume this Agreement.

     An election by Employee to terminate his employment under the provisions of
this Section 10(b) shall not  constitute a breach by Employee of this  Agreement
and shall not be deemed a voluntary  termination  of  employment by Employee for
the purpose of  interpreting  the  provisions of any of the  Company's  employee
benefit plans, programs or policies.

     (c) Upon the  occurrence  of a Change in  Control  and  thereafter:  (A) if
Employee's  employment  with the Company is  terminated  by the Company  without
Cause or as a result of the  disability  or  incapacitation  of Employee,  or by
Employee with Good Reason at any time during the period beginning on the date of
the Change in Control  and ending one (1) year after the date of such  Change in
Control,  or (B) if Employee's  employment with the Company is terminated by the
Company  without  Cause or by Employee for Good Reason  within  ninety (90) days
prior to the occurrence of a Change in Control,  then Employee shall be entitled
to receive from the Company:

          (i) a lump sum  amount,  payable  within  ten  (10)  days  after  such
     termination (or, if such termination occurred prior to a Change in Control,
     within ten (10) days after the  Change in  Control)  equal to (A) three (3)
     times  Employee's  base  salary in  effect,  or  required  to be in effect,
     immediately  prior to the  Change in  Control,  and (B) three (3) times the
     highest  annual  bonus paid or payable to Employee  within  three (3) years
     prior to the Change in Control;

          (ii)  within  ten  (10)  days  after  such  termination  (or,  if such
     termination  occurred  prior to a Change in  Control,  within ten (10) days
     after the Change in Control) equal to the Accrued Benefits;

          (iii)  payment by the Company of the premiums for Employee  (except in
     the case of Employee's  death) and  Employee's and  dependents'  health and
     welfare coverage  (including,  without  limitation,  medical,  dental, life
     insurance  and  disability  coverage) for three (3) years from the later of
     the  occurrence  of a  Change  in  Control  or the date of  termination  of
     Employee's  employment,  under the Company's health and welfare plans


                                        7

<PAGE>


     which  cover the senior  executives  of the Company or  materially  similar
     benefits  ("Continuation  Coverage"),  subject  to  Employee's  payment  of
     customary premiums (if any) in effect prior to the Change in Control;

          (iv) upon the  occurrence  of a Change in Control,  full and immediate
     vesting of all stock options and equity awards held by Employee.

     Payments under (iii) above may, at the  discretion of the Company,  be made
by continuing Employee's  participation in the plan as a terminee or by covering
Employee and Employee's dependents under substitute arrangements, provided that,
notwithstanding  anything herein to the contrary,  to the extent Employee incurs
tax that Employee  would not have incurred as an active  employee as a result of
the aforementioned coverage or the benefits provided thereunder,  Employee shall
receive  from the  Company  an  additional  grossed  up  payment  in the  amount
necessary so that Employee will have no additional cost for receiving such items
or any  additional  payment.  Notwithstanding  anything  herein to the contrary,
Employee  (and his  eligible  dependents)  shall  retain  all  rights  under the
Consolidated Omnibus Budget Reconciliation Act of 1985, as amended ("COBRA") and
such  COBRA  continuation  coverage  shall be  available  to  Employee  (and his
eligible  dependents) at the expiration of the Continuation  Coverage  described
herein.

     (d) For  purposes  of this  Agreement,  a Change in Control  shall mean the
occurrence of the following:

          (i) any person  (as  defined  in  Section  3(a)(9)  of the  Securities
     Exchange  Act of 1934,  as  amended  (the  "Exchange  Act")  and as used in
     Sections 13(d) and 14(d) thereof), excluding the Company, any subsidiary of
     the Company and any employee  benefit plan  sponsored or  maintained by the
     Company or any subsidiary of the Company (including any trustee of any such
     plan acting in his capacity as trustee),  becoming the  "beneficial  owner"
     (as  defined in Rule 13d-3 under the  Exchange  Act) of  securities  of the
     Company  representing  thirty  percent (30%) of the total  combined  voting
     power of the Company's then outstanding securities;

          (ii) the merger,  consolidation  or other business  combination of the
     Company (a "Transaction"),  other than (A) a Transaction involving only the
     Company  and  one  or  more  of  its  subsidiaries,  or  (B) a  Transaction
     immediately  following which the  stockholders  of the Company  immediately
     prior to the Transaction continue to have a majority of the voting power in
     the  resulting  entity  and no person  (other  than  those  covered  by the
     exceptions in (a) above) becomes the beneficial  owner of securities of the
     resulting entity  representing  more than twenty-five  percent (25%) of the
     voting power in the resulting entity;

          (iii) during any period of two (2)  consecutive  years beginning on or
     after  the  date  hereof,  the  persons  who  were  members  of  the  Board
     immediately before the beginning of such period (the "Incumbent Directors")
     ceasing (for any reason other than death) to constitute at least a majority
     of the Board or the board of  directors  of any


                                                         8

<PAGE>


     successor  to the  Company,  provided  that,  any  director  who  was not a
     director as of the date hereof shall be deemed to be an Incumbent  Director
     if such  director  was  elected  to the  board of  directors  by, or on the
     recommendation  of or with the  approval  of,  at least  two-thirds  of the
     directors who then qualified as Incumbent  Directors  either actually or by
     prior operation of the foregoing  unless such election,  recommendation  or
     approval occurs as a result of an actual or threatened election contest (as
     such terms are used in Rule 14a-11 of Regulation 14A promulgated  under the
     Exchange Act or any  successor  provision)  or other  actual or  threatened
     solicitation  of proxies or contests by or on behalf of a person other than
     a member of the Board; or

          (iv) the  approval by the  stockholders  of the Company of any plan of
     complete  liquidation of the Company or an agreement for the sale of all or
     substantially  all of the  Company's  assets  other than the sale of all or
     substantially  all of the assets of the  Company to a person or persons who
     beneficially own,  directly or indirectly,  at least fifty percent (50%) or
     more of the combined voting power of the outstanding  voting  securities of
     the Company at the time of such sale.

          (v) To the extent that  Employee is entitled to payment  under Section
     10(c) upon a Change in Control due to Employee's  termination without Cause
     or for Good  Reason  within  ninety (90) days prior to a Change in Control,
     any such payments under Section 10(c) shall be reduced by any payments made
     to  Employee  prior to a Change in Control  under  Sections  10(a)(iv)  and
     10(a)(v).

     11.  Limitation on Payments.

     (a) In the event that Employee shall become entitled to the payments and/or
benefits provided by Section 10(c) or any other amounts (whether pursuant to the
terms of this  Agreement or any other plan,  arrangement  or agreement  with the
Company,  any person whose  actions  result in a change of ownership  covered by
Section 280G(b)(2) of the Internal Revenue Code of 1986, as amended (the "Code")
or any  person  affiliated  with the  Company  or such  person) as a result of a
Change of  Control  (collectively  the  "Company  Payments"),  and such  Company
Payments  will be subject to the tax (the "Excise  Tax") imposed by Section 4999
of the Code (and any similar  tax that may  hereafter  be  imposed)  the Company
shall  pay to  Employee  at the  time  specified  in  subsection  (d)  below  an
additional amount (the "Gross-up  Payment") such that the net amount retained by
Employee,  after  deduction  of any Excise Tax on the Company  Payments  and any
federal,  state,  and local  income or  payroll  tax upon the  Gross-up  Payment
provided for by this paragraph (a), but before deduction for any federal, state,
and local income or payroll tax on the Company  Payments,  shall be equal to the
Company Payments. Notwithstanding the foregoing provisions of this Section 11 to
the contrary,  if it shall be determined that Employee is entitled to a Gross-up
Payment,  but the Company Payments do not exceed one hundred five percent (105%)
of the greatest  amount that could be paid to Employee  such that the receipt of
Company  Payments would not give rise to any Excise Tax (the "Reduced  Amount"),
then no Gross-up Payment shall be made to Employee and the Company Payments,  in
the aggregate, shall be reduced to the Reduced Amount.


                                        9

<PAGE>


     (b) For  purposes of  determining  whether any of the Company  Payments and
Gross-up  Payments  (collectively  the "Total  Payments") will be subject to the
Excise Tax and determining the amount of such Excise Tax: (i) the Total Payments
shall  be  treated  as  "parachute  payments"  within  the  meaning  of  Section
280G(b)(2)  of the Code,  and all  "parachute  payments"  in excess of the "base
amount" (as defined under Code Section  280G(b)(3) of the Code) shall be treated
as subject  to the Excise  Tax,  unless  and except to the extent  that,  in the
opinion of the Company's  independent  certified  public  accountants  appointed
prior to any change in ownership (as defined under Code Section  280G(b)(2))  or
tax counsel selected by such accountants (the "Accountants") such Total Payments
(in whole or in part), (A) do not constitute "parachute payments," (B) represent
reasonable  compensation  for services  actually  rendered within the meaning of
Section  280G(b)(4)  of the Code" or (C) are otherwise not subject to the Excise
Tax;  and (ii) the value of any  non-cash  benefits or any  deferred  payment or
benefit shall be determined by the Accountants in accordance with the principles
of Section 280G of the Code.

     (c) For  purposes  of  determining  the  amount  of the  Gross-up  Payment,
Employee  shall be deemed to pay federal  income  taxes at the highest  marginal
rate of federal  income  taxation  in the  calendar  year in which the  Gross-up
Payment is to be made and state and local income  taxes at the highest  marginal
rate of  taxation  in the state and  locality of  Employee's  residence  for the
calendar  year in which the  Company  Payment is to be made,  net of the maximum
reduction in federal income taxes which could be obtained from deduction of such
state and local taxes if paid in such year.  In the event that the Excise Tax is
subsequently determined by the Accountants to be less than the amount taken into
account hereunder at the time the Gross-up Payment is made, Employee shall repay
to the Company,  at the time that the amount of such  reduction in Excise Tax is
finally  determined,  the portion of the prior Gross-up Payment  attributable to
such reduction  (plus the portion of the Gross-up  Payment  attributable  to the
Excise Tax and federal, state and local income tax imposed on the portion of the
Gross-up  Payment  being  repaid by  Employee  if such  repayment  results  in a
reduction  in Excise Tax or a federal,  state and local  income tax  deduction),
plus  interest on the amount of such  repayment at the rate  provided in Section
1274(b)(2)(B)  of the  Code.  Notwithstanding  the  foregoing,  in the event any
portion of the  Gross-up  Payment to be refunded to the Company has been paid to
any  federal,  state and local tax  authority,  repayment  thereof  (and related
amounts) shall not be required until actual refund or credit of such portion has
been made to Employee,  and interest payable to the Company shall not exceed the
interest  received or credited to Employee by such tax  authority for the period
it held such  portion.  Employee and the Company shall  mutually  agree upon the
course  of action to be  pursued  (and the  method  of  allocating  the  expense
thereof) if Employee's claim for refund or credit is denied.

     In the event that the Excise Tax is later  determined by the Accountants or
the Internal  Revenue Service to exceed the amount taken into account  hereunder
at the time the Gross-up Payment is made (including by reason of any payment the
existence  or amount of which cannot be  determined  at the time of the Gross-up
Payment),  the Company shall make an additional  Gross-up  Payment in respect of
such excess (plus any interest or penalties payable with respect to such excess)
at the time that the amount of such excess is finally determined.


                                       10

<PAGE>


     (d) The Gross-up  Payment or portion thereof provided for in subsection (c)
above shall be paid not later than the  thirtieth  (30th) day following an event
occurring which subjects Employee to the Excise Tax; provided,  however, that if
the  amount of such  Gross-up  Payment  or  portion  thereof  cannot be  finally
determined  on or before such day, the Company shall pay to Employee on such day
an estimate,  as  determined  in good faith by the  Accountants,  of the minimum
amount of such payments and shall pay the  remainder of such payments  (together
with interest at the rate provided in Code Section  1274(b)(2)(B)  of the Code),
subject to further  payments  pursuant to subsection (c) hereof,  as soon as the
amount  thereof can  reasonably  be  determined,  but in no event later than the
ninetieth  (90th) day after the occurrence of the event  subjecting  Employee to
the Excise Tax. In the event that the amount of the estimated  payments  exceeds
the  amount  subsequently  determined  to  have  been  due,  such  excess  shall
constitute  a loan by the  Company to  Employee,  payable on the fifth (5th) day
after  demand by the Company  (together  with  interest at the rate  provided in
Section 1274(b)(2)(B) of the Code).

     (e) In the event of any controversy  with the Internal  Revenue Service (or
other taxing authority) under this Section 11, Employee shall permit the Company
to control  issues  related to this Section 11 (at its  expense),  provided that
such  issues  do not  potentially  materially  adversely  affect  Employee,  but
Employee  shall  control  any  other  issues.   In  the  event  the  issues  are
interrelated,  Employee and the Company shall in good faith  cooperate so as not
to  jeopardize  resolution  of either  issue,  but if the parties  cannot agree,
Employee shall make the final  determination  with regard to the issues.  In the
event of any  conference  with any  taxing  authority  as to the  Excise  Tax or
associated income taxes, Employee shall permit the representative of the Company
to accompany him, and Employee and his  representative  shall cooperate with the
Company and its representative.

     (f) The Company shall be responsible for all charges of the Accountants.

     12.  Successors.  In  addition to any  obligations  imposed by law upon any
successor to the Company, the Company will require any successor (whether direct
or  indirect,  by  purchase,  merger,  consolidation  or  otherwise)  to  all or
substantially  all of the  business  and/or  assets of the Company to  expressly
assume and agree in writing to perform this  Agreement in the same manner and to
the same  extent  that the  Company  would be  required to perform it if no such
succession had taken place.

     13. Survival.  The covenants,  agreements,  representations  and warranties
contained  in or  made  pursuant  to this  Agreement  shall  survive  Employee's
termination of employment.

     14. Entire  Agreement;  Modification.  This Agreement sets forth the entire
understanding  of the  parties  with  respect  to  the  subject  matter  hereof,
supersedes all existing  agreements  between them concerning such subject matter
(including,  without limitation, the employment agreement in effect prior to the
date hereof) and may be modified only by a written  instrument  duly executed by
each party.


                                       11

<PAGE>


     15. Notices. Any notice or other communication  required or permitted to be
given  hereunder  shall be in  writing  and shall be mailed by  certified  mail,
return receipt  requested,  or delivered against receipt to the party to whom it
is to be given at the  address of such party set forth in the  preamble  to this
Agreement (or to such other address as the party shall have furnished in writing
in accordance  with the provisions of this Section 15).  Notice to the estate of
Employee  shall be  sufficient  if  addressed  to  Employee  as provided in this
Section 15. Any notice or other  communication  given by certified mail shall be
deemed given three days after the time of  certification  thereof,  except for a
notice  changing a party's  address  which shall be deemed  given at the time of
receipt thereof.

     16. Waiver. Any waiver by either party of a breach of any provision of this
Agreement  shall  not  operate  as or be  construed  to be a waiver of any other
breach  of such  provision  or of any  breach  of any  other  provision  of this
Agreement. The failure of a party to insist upon strict adherence to any term of
this  Agreement  on one or more  occasions  shall not be  considered a waiver or
deprive that party of the right  thereafter  to insist upon strict  adherence to
that term or any other term of this  Agreement.  Any waiver  must be in writing,
signed by the party giving such waiver.

     17. Binding Effect.  Employee's rights and obligations under this Agreement
shall not be transferable  by assignment or otherwise,  such rights shall not be
subject to commutation,  encumbrance or the claims of Employee's creditors,  and
any attempt to do any of the  foregoing  shall be void.  The  provisions of this
Agreement  shall be binding  upon and inure to the benefit of  Employee  and his
heirs and personal  representatives,  and shall be binding upon and inure to the
benefit of the Company and its successors and its assigns under Section 12.

     18. No Third Party Beneficiaries. This Agreement does not create, and shall
not be construed as creating,  any rights  enforceable by any person not a party
to this Agreement (except as provided in Sections 12 and 17).

     19. Legal Fees. To the fullest  extent  permitted by law, the Company shall
promptly pay upon  submission  of  statements  all legal and other  professional
fees, costs of litigation,  prejudgment interest, and other expenses incurred in
connection with any dispute concerning payments, benefits and other entitlements
to which Employee may have under this Agreement;  provided, however, the Company
shall be reimbursed by Employee for the fees and expenses  advanced in the event
Employee's  claim is, in a material  manner,  in bad faith or frivolous  and the
arbitrator or court, as applicable,  determines that the  reimbursement  of such
fees and expenses is appropriate.

     20.  Pooling of  Interests;  Severability.  In the event that the Company's
independent  public  accountants  determine in good faith that any  provision of
this  Agreement  would preclude  "pooling of interests"  accounting and provided
that the Company engages in a transaction  which utilizes "pooling of interests"
accounting, such provision shall be deemed invalid and inoperative solely to the
extent necessary to permit "pooling of interests"  transactions.  If any portion
of this Agreement is held invalid or inoperative  (including a determination  by
the Company's independent public accountants in good faith that any provision of
this Agreement


                                       12

<PAGE>


would preclude "pooling of interests" accounting),  the other provisions of this
Agreement shall be deemed to be valid and operative and, so far as is reasonable
and possible, effect shall be given to the intent manifested by the portion held
valid or inoperative.

     21. No Duty to  Mitigate/No  Offset.  The Company agrees that if Employee's
employment with the Company is terminated  pursuant to this Agreement during the
term of this Agreement,  Employee shall not be required to seek other employment
or to attempt  in any way to reduce  any  amounts  payable  to  Employee  by the
Company  pursuant  to this  Agreement.  Further,  the  amount of any  payment or
benefit  provided for in this Agreement shall not be reduced by any compensation
earned by Employee or benefit  provided to Employee as the result of  employment
by another employer or otherwise. The Company's obligations to make the payments
provided  for in  this  Agreement  and  otherwise  to  perform  its  obligations
hereunder  shall  not  be  affected  by  any  circumstances,  including  without
limitation, any set-off, counterclaim,  recoupment, defense or other right which
the Company may have against Employee.  Notwithstanding the foregoing,  payments
and benefits  under the  Agreement  will cease to be paid and may be recouped by
the Company in the event Employee breaches any of the terms of Section 6, 7 or 8
hereunder.

     22.  Counterparts;  Governing  Law.  This  Agreement may be executed in any
number of  counterparts,  each of which shall be deemed an original,  but all of
which  together  shall  constitute  one and the  same  instrument.  It  shall be
governed  by and  construed  in  accordance  with the  laws of the  State of New
Jersey, without giving effect to the conflict of laws.

     IN WITNESS WHEREOF, the parties have duly executed this Agreement as of the
date first above written.

                                                 CELGENE CORPORATION


                                                 By:
                                                    ----------------------------
                                                      Richard C. E. Morgan
                                                      Chairman of the
                                                      Compensation Committee


                                                 By:
                                                    ----------------------------
                                                      John W. Jackson
                                                      Chief Executive Officer


                                                    ----------------------------
                                                          Robert J. Hugin


                                       13




                                                                   EXHIBIT 10.19

                       CONVERTIBLE NOTE PURCHASE AGREEMENT

                                                              September 16, 1998

Warburg Dillon Read LLC
677 Washington Blvd.
Stamford, CT 06901

Dear Sirs:

     CELGENE  CORPORATION (the "Company") wishes to confirm its arrangement with
you in connection with the issuance to you today, against payment in immediately
available  funds of the purchase price of 100% of the principal  amount thereof,
of a convertible  note in the form attached hereto as Annex I (the  "Convertible
Note") in an aggregate principal amount of $8,750,000 and convertible  initially
into  795,463  fully paid and  non-assessable  shares  (each a  "Share")  of the
Company's Common Stock,  par value $.01 per share (the "Common Stock"),  subject
to adjustment as set forth in the  Convertible  Note. In  consideration  of your
purchase of the  Convertible  Note,  the Company will pay to you, in immediately
available  funds, a fee of 5% of the principal  amount  thereof,  which shall be
netted against the purchase price of the Convertible Note.

     Simultaneously  with the issuance of the Convertible  Note pursuant to this
Agreement,  you  and  the  Company  have  entered  into  a  Registration  Rights
Agreement,  dated as of the date hereof (the "Registration  Rights  Agreement"),
pursuant to which the Company has agreed to register  the Shares  under  certain
circumstances.  All capitalized  terms not defined herein shall have the meaning
ascribed in the Convertible Note.

     1. AGREEMENT TO ISSUE AND ACCEPT. On the basis of the  representations  and
warranties and subject to the terms and conditions set forth herein, the Company
agrees  to  issue  to you,  and you  agree  to  accept  from  the  Company,  the
Convertible Note against payment of the above-specified purchase price therefor,
The closing of the issuance and acceptance of the Convertible  Note against such
payment  shall take place on the date  hereof,  at which time the Company  shall
deliver to you the

                                        1

<PAGE>

Convertible  Note,  against  delivery by you of a wire  transfer of the purchase
price to the Company's  account at PNC Bank New Jersey Trust, ABA No. 031000053,
benefit   Account   No.   8511074024,   for   further   credit  to  Account  No.
42432012020943,  Celgene Corporation, Attn: Lisa Goldhammer, Telephone No. (732)
220-3112.

     2.  REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company hereby makes
the representations and warranties to you set forth on Annex II hereto.

     3.  AGREEMENTS OF PURCHASER. You covenant and agree with the Company that:

          (a) You  will  not  offer,  sell,  assign,  hypothecate  or  otherwise
     transfer  the  Convertible   Note  except  (i)  pursuant  to  an  effective
     registration  statement under the Securities Act of 1933 (the "Act"),  (ii)
     to a person you reasonably  believe to be an "accredited  investor"  within
     the meaning of Rule 501 under the Act,  pursuant to an available  exemption
     under the Act or (iii) in  offshore  transactions  within the  meaning  and
     meeting the requirements of Rule 903 under the Act.

          (b) You  will  not  offer,  sell,  assign,  hypothecate  or  otherwise
     transfer any Shares issued upon conversion of the  Convertible  Note except
     (i) pursuant to an effective  registration statement under the Act; (ii) to
     a person you reasonably  believe to be an "accredited  investor" within the
     meaning of Rule 501 under the Act, pursuant to an available exemption under
     the Act or (iii) in an offshore  transaction within the meaning and meeting
     the requirements of Rule 903 under the Act.

          (c) You are an  "accredited  investor"  within the meaning of Rule 501
     under the Act.

          (d) You will not, in hedging transactions  effected in connection with
     your purchase and holding of the Convertible  Note,  effect sales of Common
     Stock (other than "blocks" of Common Stock, as defined in Rule 10b-18 under
     the  Securities  Exchange Act of 1934) in an amount that  exceeds,  for any
     trading day, 25% of the "trading volume" of the Common Stock (as defined in
     Rule 10b-18).

     4. CONDITIONS.  Your  obligations  under this Agreement shall be subject to
the condition that all  representations  and warranties and other  statements of
the Company herein are true and correct at and as of the closing of the purchase
and sale of the  Convertible  Note,  the  condition  that the Company shall have
performed all of its obligations hereunder theretofore to be performed,  and the
following additional conditions:

                                        2

<PAGE>


          (a) Counsel for the Company  specified  in Annex III hereto shall have
     furnished to you their respective written opinions,  dated the date of such
     closing, in form and substance satisfactory to you, to the effect set forth
     in Annex III hereto.

          (b) On the date of such closing,  the Company shall have  furnished to
     you such appropriate further information, certificates and documents as you
     may reasonably request.

     5. MISCELLANEOUS.

     (a) This  Agreement  shall be binding upon, and inure solely to the benefit
of, you and the Company and the respective  successors and assigns thereof,  and
no other  person  shall  acquire  or have any  right  under or by virtue of this
Agreement.  No  purchaser  of the  Convertible  Note  from you shall be deemed a
successor or assign by reason merely of such purchase.

     (b) Any notice or other  communication  required or  permitted  to be given
hereunder shall be deemed effectively given when personally delivered,  telexed,
transmitted by facsimile or mailed by pre-paid  certified  mail,  return receipt
requested,  or by telephone  when  confirmed in writing by one of the  preceding
methods addressed as follows (as applicable):




                                        3

<PAGE>


               If to the Company, to:

               Celgene Corporation
               7 Powder Horn Drive
               Warren, NJ 07059

               Attention: John W. Jackson
               Telephone Number: (732) 271-1001
               Facsimile Transmission Number: (732) 805-3931

               with a copy to:

               Proskauer Rose LLP
               1585 Broadway
               New York, NY 10036

               Attention: Robert A. Cantone, Esq.
               Telephone Number: (212) 969-3000
               Facsimile Transmission Number: (212) 969-2900

               If to Warburg Dillon Read LLC, to:

               Warburg Dillon Read LLC
               677 Washington Blvd.
               Stamford, CT 06901

               Attention: General Counsel
                          Capital Markets '
               Telephone Number: (203) 719-3000
               Facsimile Transmission Number: (201) 719-6097

or to such other  address or number and to the attention of such other person as
either party may designate by written notice to the other party. Notice shall be
effective upon actual receipt.

     (c) THIS  AGREEMENT  SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE  WITH
THE LAWS OF THE STATE OF NEW YORK.

     (d) Time shall be of the essence in the performance of this Agreement.

                                       4

<PAGE>



     (e) This  Agreement may be executed by the parties  hereto in any number of
counterparts,  each of which  shall be  deemed to be an  original,  but all such
respective counterparts shall together constitute one and the same instrument.

                                              Very truly yours,

                                              CELGENE CORPORATION

                                              By:
                                                 -------------------------------
                                                 Name:
                                                 Title:

Accepted as of the date hereof:

WARBURG DILLON READ LLC

By:
   -------------------------------
   Name:
   Title:



<PAGE>


                                                                        ANNEX II

                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

     (a) Each of the  Company's  Annual  Report on Form 10-K for the year  ended
December 31, 1997, and each report filed by the Company pursuant to the Exchange
Act  after the  filing of such  Annual  Report on Form 10-K  (collectively,  the
"Exchange Act Reports")  conforms in all material respects with the requirements
of the Exchange Act and the rules and regulations of the Securities and Exchange
Commission  thereunder;  and no such  document,  when it was  filed  (or,  if an
amendment  with respect to any such document was filed,  when such amendment was
filed),  contained any untrue statement of a material fact or omitted to state a
material fact required to be stated  therein or necessary to make the statements
therein,  in the light of the  circumstances  under  which they were  made,  not
misleading,

     (b) All the  outstanding  shares of capital  stock of the Company have been
duly  authorized and validly issued and are fully paid,  non-assessable  and not
subject to any preemptive or similar rights;  the Shares initially issuable upon
conversion of the  Convertible  Note have been duly and validly  authorized  and
reserved for issuance out of the  Company's  authorized  and unissued  shares of
Common Stock and, when issued and delivered in accordance with the provisions of
the  Convertible  Note  will  be  duly  and  validly  issued,   fully  paid  and
non-assessable and will conform to the description of the Common Stock contained
in the Company's Registration Statement on Form 8-A, File No. 0-16132.

     (c) The  Convertible  Note has been duly  authorized  and,  when issued and
delivered pursuant to this Agreement,  will have been duly executed,  issued and
delivered  and will  constitute a valid and legally  binding  obligation  of the
Company;  and the  Registration  Rights  Agreement has been duly authorized and,
when executed and delivered by the parties thereto,  will constitute a valid and
legally  binding  obligation of the Company,  enforceable in accordance with its
terms, subject, as to enforcement, to bankruptcy, insolvency, reorganization and
other laws of general  applicability  relating to or affecting creditors' rights
and to general equity principles.

     (d)  The  execution,  delivery  and  performance  of  this  Agreement,  the
Registration  Rights  Agreement  and the  Convertible  Note,  compliance  by the
Company  with all  provisions  hereof and  thereof and the  consummation  of the
transactions   contemplated   hereby  and  the  issuance  and  delivery  of  the
Convertible  Note will not  conflict  with or  constitute a breach of any of the
terms or  provisions  of, or a default  under,  the  charter  or  by-laws of the
Company  or any of  its  subsidiaries,  or any  agreement,  indenture  or  other
instrument to which it or any of its  subsidiaries  is a party or by which it or
any of its subsidiaries or their respective  properties are bound, or violate or
conflict with any laws,  administrative  regulations or rulings or court decrees
applicable to the Company, any of its subsidiaries or their respective property;


<PAGE>


and, except (i) as required pursuant to the Registration  Rights  Agreement,  or
(ii) for the disclosure  required to be included in the Company's next Quarterly
Report on Form 10-Q, when filed, pursuant to Item 2(c) of Form 10-Q, no consent,
approval,  authorization  or order of or filing or  registration  with, any such
court or governmental agency or body is required for the execution, delivery and
performance  of  this  Agreement,  the  Registration  Rights  Agreement  and the
Convertible  Note  by the  Company  and  the  consummation  of the  transactions
contemplated hereby and thereby.

     (e) Except as otherwise set forth in the Exchange Act Reports, there are no
material legal or governmental  proceedings  pending to which the Company or any
of its subsidiaries is a party or of which any of their  respective  property is
the subject which, if determined  adversely to the Company or its  subsidiaries,
might have a material  adverse effect on the business,  condition  (financial or
otherwise),  stockholders' equity, properties,  business prospects or results of
operations  of the Company and its  subsidiaries,  taken as a whole (a "Material
Adverse  Effect"),  and,  to  the  best  of the  Company's  knowledge,  no  such
proceedings are threatened or contemplated.

     (f) The Company is not, and the Company covenants that at any time when the
Convertible Note is outstanding it will not be, an open-end  investment company,
unit investment trust or face-amount  certificate company that is or is required
to be registered under Section 8 of the United States Investment  Company Act of
1940, as amended.

     (g) When the  Convertible  Note is issued and  delivered  pursuant  to this
Agreement,  the  Convertible  Note  will not be of the same  class  (within  the
meaning of Rule 144A under the Securities  Act of 1933) as securities  which are
listed on a  national  securities  exchange  registered  under  Section 6 of the
Exchange Act or quoted in a U.S. automated inter-dealer quotation system.

     (h) The Company is, and the Company  covenants  that while the  Convertible
Note is  outstanding  it will  remain,  subject  to  Section  13 or 15(d) of the
Exchange Act.

     (i) Neither the Company nor any person  acting on its behalf has offered or
sold the  Convertible  Note by  means of any  general  solicitation  or  general
advertising within the meaning of Rule 502(c) under the Act.


                                       2

<PAGE>


                                                                       ANNEX III

                           OPINION OF COMPANY COUNSEL

     (a) The  Company  has been duly  incorporated,  is  validly  existing  as a
corporation in good standing under the laws of its jurisdiction of incorporation
and has the corporate  power and authority  required to carry on its business as
described  in the  Exchange  Act  Reports  and to own,  lease  and  operate  its
properties.

     (b) All the  outstanding  shares of Common Stock have been duly  authorized
and  validly  issued and are fully paid,  non-assessable  and not subject to any
preemptive or similar rights.

     (c) The Shares  initially  issuable upon conversion of the Convertible Note
have  been duly  authorized  and  reserved  for  issuance  and when  issued  and
delivered upon  conversion in accordance  with the provisions of the Convertible
Note,  will have been validly issued and will be fully paid and  non-assessable,
and the  issuance  of such Shares is not  subject to any  preemptive  or similar
rights.

     (d) This Agreement has been duly authorized,  executed and delivered by the
Company.

     (e) The Convertible  Note has been duly  authorized,  executed,  issued and
delivered,  and  constitutes  the valid and legally  binding  obligation  of the
Company  enforceable  in  accordance  with its  terms,  subject  to  bankruptcy,
insolvency, fraudulent transfer, reorganization,  moratorium and similar laws of
general applicability  relating to or affecting creditors' rights and to general
equity principles.

     (f) The Registration  Rights  Agreement has been duly authorized,  executed
and  delivered  by the  Company  and  constitutes  a valid and  legally  binding
agreement of the Company,  enforceable in accordance with its terms,  subject to
bankruptcy,  insolvency,  fraudulent  transfer,  reorganization,  moratorium and
similar laws of general applicability relating to or affecting creditors' rights
and to general  equity  principles;  provided  that such counsel need express no
opinion with respect to Section 6 of such Agreement.

     (g) The  authorized  capital  stock of the  Company,  including  the Common
Stock,  conforms as to legal matters to the description thereof contained in the
Company's Registration Statement on Form 8-A, File No. 0-16132.

     (h) Except (i) as required  pursuant to the Registration  Rights Agreement,
or (ii)  for the  disclosure  required  to be  included  in the  Company's  next
Quarterly  Report on Form 10-Q, when filed,  pursuant to Item 2(c) of Form 10-Q,
no consent, approval,  authorization or order of or filing or registration with,
any court or governmental


<PAGE>


agency or body is required for the execution,  delivery and  performance of this
Agreement,  the  Registration  Rights  Agreement and the Convertible Note by the
Company and the consummation of the transactions  contemplated by this Agreement
and thereby,

     (i)  The  execution,  delivery  and  performance  of  this  Agreement,  the
Registration   Rights  Agreement  and  the  Convertible  Note  by  the  Company,
compliance  by the Company  with all the  provisions  hereof and thereof and the
consummation  of the  transactions  contemplated  hereby  and  thereby  will not
conflict with or constitute a breach of any of the terms or provisions  of, or a
default under, the charter or by-laws of the Company or any agreement, indenture
or other  instrument  to which the Company is a party or by which the Company or
its properties are bound,  or violate or conflict with any laws,  administrative
regulations  or  rulings  or court  decrees  applicable  to the  Company  or its
properties  in any case which is  reasonably  likely to have a Material  Adverse
Effect.

     (j) The  Company is not an open-end  investment  company,  unit  investment
trust or face-amount certificate company that is or is required to be registered
under Section 8 of the United States Investment Company Act of 1940, as amended.






                                       2



                                                                   EXHIBIT 10.20

     THIS SECURITY AND THE COMMON STOCK  ISSUABLE UPON ITS  CONVERSION  HAVE NOT
BEEN  REGISTERED  UNDER  THE  U.S.  SECURITIES  ACT OF  1933,  AS  AMENDED  (THE
"SECURITIES  ACT"),  AND  MAY  NOT  BE  OFFERED,   SOLD,  PLEDGED  OR  OTHERWISE
TRANSFERRED  EXCEPT PURSUANT TO AN AVAILABLE  EXEMPTION FROM REGISTRATION  UNDER
THE SECURITIES ACT AND IN ACCORDANCE WITH ALL APPLICABLE  SECURITIES LAWS OF THE
STATES OF THE UNITED STATES AND OTHER JURISDICTIONS.

                               CELGENE CORPORATION

                 9.25 % CONVERTIBLE NOTE DUE SEPTEMBER 16, 2003

No. R-1                                                               $8,750,000

     CELGENE  CORPORATION,  a corporation  duly organized and existing under the
laws of Delaware (the "Company") for value  received,  hereby promises to pay to
Warburg  Dillon Read LLC, or  registered  assigns,  the  principal  sum of eight
million,  seven hundred and fifty thousand Dollars ($8,750,000) on September 16,
2003 and to pay interest  thereon,  from  September  16, 1998,  or from the most
recent  interest  payment date to which  interest has been paid or duly provided
for,  semiannually on March 16 and September 16 in each year,  commencing  March
16, 1999, at the rate of 9.25% per annum, until the principal hereof is due, and
at the rate of 9.25% per annum on any overdue  principal  and  premium,  if any,
and, to the extent  permitted by law, on any overdue  interest.  The interest so
payable,  and punctually paid or duly provided for, on any interest payment date
will  be  paid  to the  person  in  whose  name  this  Security  (or one or more
predecessor  Securities)  is  registered at the close of business on the regular
record  date for  such  interest,  which  shall be the  March 1 or  September  1
(whether  or not a  business  day),  as the case  may be,  next  preceding  such
interest  payment date.  Payment of the  principal of (and premium,  if any, on)
this Security  shall be made upon the surrender of this Security to the Company,
at its office at 7 Powder Horn  Drive,  Warren,  NJ 07059 (or such other  office
within  the  United  States as shall be  notified  by the  Company to the holder
hereof) (the "Designated Office"), in such coin or currency of the United States
of America as at the time of payment  shall be legal  tender for the  payment of
public and private debts, by transfer to a U.S. dollar account maintained by the
payee with a bank in the United  States of America.  Payment of interest on this
Security shall be made by wire transfer to a U.S.  dollar account  maintained by
the payee  with a bank in the United  States of  America,  provided  that if the
holder shall not have furnished wire  instructions  in writing to the Company no
later than the record date relating to an interest  payment  date,  such payment
may be made by U.S.  dollar check  mailed to the address of the person  entitled
thereto as such  address  shall  appear in the  Company  security  register.  In
respect of any  interest  payment  date,  the Company  may, at its  election but
subject to  fulfillment  of the conditions set forth in Section 6 and subject to
the limitations set forth therein, pay all or a portion of the interest on this


<PAGE>


Security  in shares of Common  Stock  having a fair  market  value  equal to the
amount then payable hereunder, as described in Section 6.

     1. Redemption. This Security is subject to redemption upon not less than 30
nor more than 60 days'  notice by mail,  at any time on or after  September  16,
2000,  as a whole or in part,  (in any amount  that is an  integral  multiple of
$1000)  at the  election  of the  Company,  at a  redemption  price  of 103% the
principal amount thereof, together with accrued interest to the redemption date,
but  interest  installments  whose  stated  maturity  is on  or  prior  to  such
redemption  date will be payable to the holder of this Security,  or one or more
predecessor  Securities,  of  record at the close of  business  on the  relevant
record dates referred to on the face hereof; provided, however, that the Company
may not redeem  this  Security  on or prior to  September  16,  2001  unless the
Closing Price of the Common Stock exceeds 225% of the Conversion  Price for each
Trading Day in a period of 20  Consecutive  Trading Days  commencing not earlier
than  September  16, 2000.  The term  "Conversion  Price" on any day shall equal
$1,000 divided by the Conversion Rate in effect on each such day.

     2.  Conversion.  (a) The holder of this Security is entitled at any time on
or after  September  16, 1999 and before the close of business on September  16,
2003 (or, in case this Security or a portion  hereof is called for redemption or
the holder  hereof has  exercised his right to require the Company to repurchase
this  Security  or a portion  hereof,  then in respect of this  Security or such
portion hereof, as the case may be, until and including, but (unless the Company
defaults in making the payment due upon  redemption or  repurchase,  as the case
may  be)  not  after,  the  close  of  business  on the  redemption  date or the
Repurchase Date, as the case may be) to convert this Security (or any portion of
the principal amount hereof that is an integral multiple of $1,000),  into fully
paid and  nonassessable  1,000 shares  (calculated as to each  conversion to the
nearest  1/100 of a share) of Common  Stock of the  Company at the rate of 90.91
shares of Common Stock for each $1,000  principal  amount of Security (or at the
current  adjusted  rate if an adjustment  has been made as provided  below) (the
"Conversion  Rate") by surrender of this Security,  duly endorsed or assigned to
the Company or in blank to the Company at the Designated Office,  accompanied by
written  notice to the Company  that the holder  hereof  elects to convert  this
Security (or if less than the entire principal amount hereof is to be converted,
specifying the portion hereof to be converted).  Upon surrender of this Security
for conversion,  the holder will be entitled to receive the interest accruing on
the principal  amount of this Security  then being  converted  from the interest
payment  date  next  preceding  the  date of  such  conversion  to such  date of
conversion.  No payment or adjustment is to be made on conversion  for dividends
on the Common Stock issued on conversion hereof. No fractions of shares or scrip
representing  fractions of shares will be issued on  conversion,  but instead of
any fractional  interest,  the Company shall pay a cash adjustment,  computed on
the basis of the Closing  Price of the Common  Stock on the date of  conversion,
or, at its option, the Company shall round up to the next higher whole share.

     Notwithstanding  the  foregoing,  at no time will the holder be entitled to
convert this Security into shares of Common Stock that, together with the number
of shares of Common  Stock owned (or deemed for bank  regulatory  purposes to be
owned)  by  such  holder  and its  affiliates  as set  forth  in the  notice  of
conversion, represent more than 4.9% of the Common Stock then outstanding. If at
any time the  Conversion  Rate and the principal  amount of this Security  would
result in a greater number of shares being issuable upon conversion, then for so
long as such condition  shall exist,  upon exercise of the conversion  right the
holder shall receive (i) up to that number of shares of Common

                                       2

<PAGE>


Stock that,  together with the number of shares of Common Stock owned (or deemed
for bank  regulatory  purposes to be owned) by such holder and its affiliates as
set forth in the notice of  conversion,  represent 4.9% of the Common Stock then
outstanding,  and (ii) an amount  (in cash but not less than  zero),  payable in
immediately available funds, determined pursuant to the formula:

               C  = (P/CR - I) x CP

         where C  = the cash amount receivable by the holder;

               P  = the principal amount of this Security being converted;

               CR = the Conversion Rate;

               I  = the number of shares issuable  pursuant to clause (i) above;
                    and

               CP = the  Closing  Price  of the  Common  Stock  on the  date  of
                    conversion.

     (b) The Conversion  Rate shall be subject to adjustments  from time to time
as follows:

          (1) In  case  the  Company  shall  pay or  make a  dividend  or  other
     distribution on any class of capital stock of the Company payable in shares
     of Common Stock,  the Conversion  Rate in effect at the opening of business
     on the day  following  the  Determination  Date for such  dividend or other
     distribution  shall be  increased  by dividing  such  Conversion  Rate by a
     fraction  of which the  numerator  shall be the  number of shares of Common
     Stock outstanding at the close of business on such  Determination  Date and
     the  denominator  shall be the sum of such  number of shares  and the total
     number of shares  constituting  such dividend or other  distribution,  such
     increase to become effective  immediately  after the opening of business on
     the  day  following  such  Determination  Date.  For the  purposes  of this
     paragraph (1), the number of shares of Common Stock at any time outstanding
     shall not  include  shares  held in the  treasury  of the Company but shall
     include shares issuable in respect of scrip certificates  issued in lieu of
     fractions of shares of Common Stock.  The Company will not pay any dividend
     or make any  distribution on shares of Common Stock held in the treasury of
     the Company.

          (2) Subject to the last  sentence  of  paragraph  (7) of this  Section
     2(b), in case the Company  shall issue  rights,  options or warrants to all
     holders of its Common Stock  entitling  them to  subscribe  for or purchase
     shares of Common  Stock at a price per share less than the  current  market
     price per share  (determined  as provided in paragraph  (8) of this Section
     2(b)) of the Common Stock on the Determination  Date for such distribution,
     the  Conversion  Rate in  effect  at the  opening  of  business  on the day
     following  such  Determination  Date shall be  increased  by dividing  such
     Conversion Rate by a fraction of which the numerator shall be the number of
     shares  of  Common  Stock  outstanding  at the  close of  business  on such
     Determination  Date plus the  number of  shares of Common  Stock  which the
     aggregate  of the  offering  price of the total  number of shares of Common
     Stock so offered  for  subscription  or  purchase  would  purchase  at such
     current market price and the  denominator  shall be the number of shares of
     Common  Stock  outstanding  at the close of business on such  Determination
     Date plus the

                                       3

<PAGE>


     number of shares of Common Stock so offered for  subscription  or purchase,
     such increase to become effective immediately after the opening of business
     on the day  following  such  Determination  Date.  For the purposes of this
     paragraph (2), the number of shares of Common Stock at any time outstanding
     shall not  include  shares  held in the  treasury  of the Company but shall
     include shares issuable in respect of scrip certificates  issued in lieu of
     fractions of shares of Common Stock. The Company will not issue any rights,
     options  or  warrants  in  respect  of shares of Common  Stock  held in the
     treasury of the Company.

          (3) In case  outstanding  shares of Common  Stock shall be  subdivided
     into a greater  number of shares of Common Stock,  the  Conversion  Rate in
     effect at the opening of business on the day  following  the day upon which
     such subdivision becomes effective shall be proportionately increased, and,
     conversely,  in case  outstanding  shares of  Common  Stock  shall  each be
     combined into a smaller  number of shares of Common Stock,  the  Conversion
     Rate in effect at the opening of business on the day following the day upon
     which such combination becomes effective shall be proportionately  reduced,
     such  increase  or  reduction,  as the case  may be,  to  become  effective
     immediately after the opening of business on the day following the day upon
     which such subdivision or combination becomes effective.

          (4) Subject to the last  sentence  of  paragraph  (7) of this  Section
     2(b), in case the Company  shall,  by dividend or otherwise,  distribute to
     all holders of its Common Stock  evidences of its  indebtedness,  shares of
     any class of capital stock, or other property  (including  securities,  but
     excluding (i) any rights,  options or warrants referred to in paragraph (2)
     of this Section 2(b) (ii) any dividend or distribution  paid exclusively in
     cash,  (iii) any dividend or  distribution  referred to in paragraph (1) of
     this Section  2(b) and (iv) any merger or  consolidation  to which  Section
     2(h) applies), the Conversion Rate shall be adjusted so that the same shall
     equal  the rate  determined  by  dividing  the  Conversion  Rate in  effect
     immediately  prior to the close of business on the  Determination  Date for
     such distribution by a fraction of which the numerator shall be the current
     market price per share  (determined  as provided in  paragraph  (8) of this
     Section 2(b)) of the Common Stock on such  Determination Date less the then
     fair market value (as determined in good faith by the Board of Directors of
     the  Company)  of the  portion  of  the  assets,  shares  or  evidences  of
     indebtedness so distributed applicable to one share of Common Stock and the
     denominator  shall be such  current  market  price per share of the  Common
     Stock, such adjustment to become effective immediately prior to the opening
     of business on the day following such  Determination  Date. If the Board of
     Directors determines the fair market value of any distribution for purposes
     of this  paragraph  (4) by reference  to the actual or when issued  trading
     market for any securities comprising such distribution, it must in doing so
     consider  the prices in such market over the same period used in  computing
     the  current  market  price per share  pursuant  to  paragraph  (8) of this
     Section 2(b).

          (5) In case the Company shall,  by dividend or otherwise,  make a Cash
     Distribution,  then, and in each such case,  immediately after the close of
     business  on  the  Determination  Date  for  such  Cash  Distribution,  the
     Conversion  Rate shall be  adjusted  so that the same shall  equal the rate
     determined by dividing the Conversion Rate in effect  immediately  prior to
     the close of  business  on such  Determination  Date by a fraction  (a) the
     numerator  of which  shall be equal to the current  market  price per share
     (determined  as  provided in  paragraph  (8) of this  Section  2(b)) of the
     Common  Stock  on such  Determination  Date  less an  amount  equal  to the
     quotient of

                                       4

<PAGE>


     (1) the  amount  of such Cash  Distribution  divided  by (2) the  number of
     shares of Common Stock outstanding on such  Determination  Date and (b) the
     denominator  of which shall be equal to the current  market price per share
     (determined  as  provided in  paragraph  (8) of this  Section  2(b)) of the
     Common Stock on such Determination Date.

          (6) In case  the  Company  or any  Subsidiary  shall  make  an  Excess
     Purchase  Payment,  then, and in each such case,  immediately  prior to the
     opening of business  on the day after the tender  offer in respect of which
     such Excess  Purchase  Payment is to be made expires,  the Conversion  Rate
     shall be  adjusted  so that the same  shall  equal the rate  determined  by
     dividing the Conversion  Rate in effect  immediately  prior to the close of
     business on the Determination  Date for such tender offer by a fraction (a)
     the numerator of which shall be equal to the current market price per share
     (determined  as  provided in  paragraph  (8) of this  Section  2(b)) of the
     Common  Stock  on such  Determination  Date  less an  amount  equal  to the
     quotient of (A) the Excess  Purchase  Payment  divided by (B) the number of
     shares of Common Stock  outstanding  (including any tendered  shares) as of
     the  Determination  Date less the number of all shares validly tendered and
     not withdrawn as of the Determination Date and (b) the denominator of which
     shall be  equal to the  current  market  price  per  share  (determined  as
     provided in paragraph  (8) of this Section  2(b)) of the Common Stock as of
     such Determination Date.

          (7) The  reclassification  of Common Stock into securities  other than
     Common  Stock  (other than any  reclassification  upon a  consolidation  or
     merger to which  Section  2(h)  applies)  shall be deemed to involve  (a) a
     distribution of such  securities  other than Common Stock to all holders of
     Common  Stock (and the  effective  date of such  reclassification  shall be
     deemed to be the Determination Date), and (b) a subdivision or combination,
     as the case may be, of the  number of  shares of Common  Stock  outstanding
     immediately  prior to such  reclassification  into the  number of shares of
     Common Stock outstanding  immediately thereafter (and the effective date of
     such  reclassification  shall be  deemed  to be "the day  upon  which  such
     subdivision  becomes  effective"  or "the day upon which  such  combination
     becomes  effective",  as the case may be,  and  "the  day upon  which  such
     subdivision  or  combination  becomes  effective"'  within  the  meaning of
     paragraph  (3) of this  Section  2(b)).  Rights or  warrants  issued by the
     Company to all holders of its Common Stock entitling the holders thereof to
     subscribe for or purchase shares of Common Stock,  which rights or warrants
     (i) are deemed to be transferred with such shares of Common Stock, (ii) are
     not exercisable and (iii) are also issued in respect,  of future  issuances
     of Common  Stock,  in each case in  clauses  (i)  through  (iii)  until the
     occurrence  of a specified  event or events  ("Trigger  Event"),  shall for
     purposes of this Section 2(b) not be deemed issued until the  occurrence of
     the earliest Trigger Event.

          (8) For the purpose of any computation  under paragraphs (2), (4), (5)
     or (6) of this  Section  2(b) the current  market price per share of Common
     Stock on any date shall be  calculated  by the  Company and be deemed to be
     the average of the daily Closing  Prices for the five  consecutive  Trading
     Days  selected  by the  Company  commencing  not more than 10 Trading  Days
     before,  and ending not later than,  the earlier of the day in question and
     the day before the "ex" date with respect to the  issuance or  distribution
     requiring such  computation.  For purposes of this paragraph,  the term "ex
     date",  when used with respect to any issuance or  distribution,  means the
     first date on which the Common Stock trades  regular way in the  applicable
     securities

                                       5

<PAGE>


     market  or on the  applicable  securities  exchange  without  the  right to
     receive such issuance or distribution.

          (9) No adjustment in the Conversion Rate shall be required unless such
     adjustment  (plus any  adjustments  not  previously  made by reason of this
     paragraph  (9))  would  require an  increase  or  decrease  of at least one
     percent in such rate;  provided,  however,  that any  adjustments  which by
     reason of this  paragraph  (9) are not required to be made shall be carried
     forward  and  taken  into  account  in  any  subsequent   adjustment.   All
     calculations  under this  Section 2 shall be made to the nearest cent or to
     the nearest one-hundredth of a share, as the case may be.

          (10) The Company may make such increases in the  Conversion  Rate, for
     the  remaining  term of the  Securities or any shorter term, in addition to
     those  required by  paragraphs  (1),  (2),  (3),  (4),  (5) and (6) of this
     Section  2(b) as it considers to be advisable in order to avoid or diminish
     any income tax to any holders of shares of Common Stock  resulting from any
     dividend  or  distribution  of stock or  issuance  of rights or warrants to
     purchase  or  subscribe  for  stock or from any event  treated  as such for
     income tax purposes.

     (c) Whenever the  Conversion  Rate is adjusted as provided in Section 2(b),
the Company  shall  compute the  adjusted  Conversion  Rate in  accordance  with
Section  2(b) and shall  prepare  a  certificate  signed by the chief  financial
officer of the Company setting forth the adjusted Conversion Rate and showing in
reasonable  detail  the facts upon which  such  adjustment  is based,  and shall
promptly deliver such certificate to the holder of this Security.

     (d) In case:

          (1) the Company shall declare a dividend or other  distribution on its
     Common  Stock  payable  (i)  otherwise  than  exclusively  in  cash or (ii)
     exclusively in cash in an amount that would require any adjustment pursuant
     to Section 2(b); or

          (2) the Company  shall  authorize  the  granting to the holders of its
     Common Stock of rights,  options or warrants to  subscribe  for or purchase
     any shares of capital stock of any class or of any other rights; or

          (3) of any  reclassification of the Common Stock of the Company, or of
     any consolidation, merger or share exchange to which the Company is a party
     and for which approval of any  shareholders of the Company is required,  or
     of the conveyance,  sale,  transfer or lease of all or substantially all of
     the assets of the Company; or

          (4)  of the  voluntary  or  involuntary  dissolution,  liquidation  or
     winding up of the Company; or

          (5) the Company or any  Subsidiary  shall  commence a tender offer for
     all or a portion of the  Company's  outstanding  shares of Common Stock (or
     shall amend any such tender offer);

                                       6

<PAGE>


then the Company shall cause to be delivered to the holder of this Security,  at
least 20 days (or 10 days in any case  specified  in  clause  (1) or (2)  above)
prior  to the  applicable  record,  expiration  or  effective  date  hereinafter
specified,  a notice  stating  (x) the date on which a record is to be taken for
the purpose of such dividend, distribution,  rights, options or warrants, or, if
a record is not to be taken, the date as of which the holders of Common Stock of
record  to be  entitled  to such  dividend,  distribution,  rights,  options  or
warrants are to be  determined,  (y) the date on which the right to make tenders
under such tender offer expires or (z) the date on which such  reclassification,
consolidation,   merger,   conveyance,   transfer,  sale,  lease,   dissolution,
liquidation  or winding up is expected to become  effective,  and the date as of
which it is expected that holders of Common Stock of record shall be entitled to
exchange  their shares of Common Stock for  securities,  cash or other  property
deliverable  upon  such  reclassification,  consolidation,  merger,  conveyance,
transfer,  sale,  lease,  dissolution,  liquidation  or winding up.  Neither the
failure to give such notice nor any defect  therein shall affect the legality or
validity of the proceedings described in clauses (1) through (5) of this Section
2(d).

     (e) The Company  shall at all times reserve and keep  available,  free from
preemptive  rights,  out of its  authorized but unissued  Common Stock,  for the
purpose of effecting the  conversion of the Security,  the full number of shares
of Common Stock then issuable upon the conversion of this Security.

     (f) Except as provided in the next  sentence,  the Company will pay any and
all taxes and duties  that may be payable in respect of the issue or delivery of
shares of Common Stock on  conversion of this  Security.  The Company shall not,
however,  be  required to pay any tax or duty which may be payable in respect of
any  transfer  involved in the issue and delivery of shares of Common Stock in a
name  other  than that of the  holder  of this  Security,  and no such  issue or
delivery  shall be made  unless and until the person  requesting  such issue has
paid to the Company the amount of any such tax or duty,  or has  established  to
the satisfaction of the Company that such tax or duty has been paid.

     (g) The  Company  agrees  that all  shares  of  Common  Stock  which may be
delivered upon  conversion of the Security,  upon such delivery,  will have been
duly authorized and validly issued and will be fully paid and nonassessable (and
shall be issued out of the Company's  authorized but unissued Common Stock) and,
except as provided in Section  2(f),  the Company will pay all taxes,  liens and
charges with respect to the issue thereof.

     (h) In ease of any consolidation of the Company with any other person,  any
merger of the Company into another  person or of another person into the Company
(other than a merger which does not result in any reclassification,  conversion,
exchange or cancellation  of outstanding  shares of Common Stock of the Company)
or any conveyance,  sale,  transfer or lease of all or substantially  all of the
properties and assets of the Company, the person formed by such consolidation or
resulting from such merger or which acquires such properties and assets,  as the
case may be,  shall  execute  and  deliver  to the  holder  of this  Security  a
supplemental  agreement  providing  that such  holder has the right  thereafter,
during the period this  Security  shall be  convertible  as specified in Section
2(a), to convert this Security only into the kind and amount of securities, cash
and other property receivable upon such consolidation, merger, conveyance, sale,
transfer or lease  (including  any Common Stock  retainable)  by a holder of the
number of shares of Common Stock of the Company into which this  Security  might
have been converted immediately prior to such consolidation, merger, conveyance,
sale, transfer or

                                       7

<PAGE>


lease,  assuming  such holder of Common Stock of the Company (i) is not a person
with which the  Company  consolidated,  into which the  Company  merged or which
merged into the Company or to which such conveyance, sale, transfer or lease was
made,  as the  case  may  be (a  "Constituent  Person"),  or an  Affiliate  of a
Constituent  Person and (ii) failed to exercise his rights of election,  if any,
as to the kind or amount of securities,  cash and other property receivable upon
such consolidation,  merger, conveyance,  sale, transfer or lease (provided that
if the kind or amount of  securities,  cash and other property  receivable  upon
such consolidation, merger, conveyance, sale, transfer, or lease is not the same
for each share of Common  Stock of the Company  held  immediately  prior to such
consolidation,  merger,  conveyance,  sale,  transfer  or lease by others than a
Constituent  Person or an Affiliate  thereof and in respect of which such rights
of election shall not have been exercised  ("Non-electing  Share"), then for the
purpose of this Section 2(h) the kind and amount of  securities,  cash and other
property receivable upon such consolidation,  merger, conveyance, sale, transfer
or lease by the  holders of each  Non-electing  Share  shall be deemed to be the
kind and  amount so  receivable  per share by a  plurality  of the  Non-electing
Shares).  Such supplemental  agreement shall provide for adjustments  which, for
events subsequent to the effective date of such supplemental agreement, shall be
as nearly  equivalent as may be practicable to the  adjustments  provided for in
this Section 2. The above  provisions of this Section 2(h) shall similarly apply
to successive consolidations,  mergers, conveyances, sales, transfers or leases.
In this paragraph,  "securities of the kind receivable" upon such consolidation,
merger,  conveyance,  transfer,  sale or lease by a holder of Common Stock means
securities that, among other things,  are registered and transferable  under the
Securities Act, and listed and approved for quotation in all securities markets,
in each case to the same extent as such  securities so receivable by a holder of
Common Stock.

     (i) The  Company  (i) will effect all  registrations  with,  and obtain all
approvals  by, all  governmental  authorities  that may be  necessary  under any
United States  Federal or state law  (including  the Securities Act of 1933, the
Securities  Exchange Act of 1934 and state securities and Blue Sky laws) for the
shares of Common Stock issuable upon  conversion of this Security to be lawfully
issued and delivered as provided  herein,  and  thereafter  publicly  traded (if
permissible  under such  Securities Act) and qualified or listed as contemplated
by clause (ii) (it being  understood  that the Company  shall not be required to
register the Common Stock  issuable on  conversion  hereof under the  Securities
Act, except pursuant to the Registration  Rights  Agreement  between the Company
and the  initial  holder of this  Security);  and (ii)  will list the  shares of
Common Stock required to be issued and delivered upon  conversion of Securities,
prior to such  issuance or delivery,  on each  national  Securities  exchange on
which outstanding Common Stock is listed or quoted at the time of such delivery,
or if the Common Stock is not then listed on any securities exchange, to qualify
the  Common  Stock for  quotation  on the Nasdaq  National  Market or such other
inter-dealer quotation system, if any, on which the Common Stock is then quoted.

     (j) For purposes hereof:

     "Affiliate"  of any  specified  person means any other  person  directly or
indirectly  controlling  or  controlled  by or under  direct or indirect  common
control  with  such  specified  person.  For the  purposes  of this  definition,
"control",  when used with respect to any specified  person,  means the power to
direct the  management  and  policies of such  person,  directly or  indirectly,
whether  through the ownership of voting  securities,  by contract or otherwise;
and the terms  "controlling" and "controlled"  have meanings  correlative to the
foregoing.

                                       8

<PAGE>


     "Cash Distribution" means the distribution by the Company to all holders of
its Common Stock of cash,  other than any cash that is distributed upon a merger
or  consolidation  to which  Section 2(h)  applies or as part of a  distribution
referred to in paragraph (4) of Section 2(b).

     "Closing Price" means, with respect to the Common Stock of the Company, for
any day, the reported last sale price per share on the Nasdaq  National  Market,
or, if the Common  Stock is not  admitted  to  trading  on the  Nasdaq  National
Market, on the principal national securities exchange or inter-dealer  quotation
system on which the Common  Stock is listed or admitted  to  trading,  or if not
admitted  to trading on the Nasdaq  National  Market,  or listed or  admitted to
trading on any national  securities  exchange or inter-dealer  quotation system,
the   average  of  the   closing   bid  and  asked   prices  per  share  in  the
over-the-counter  market as furnished by any New York Stock Exchange member firm
selected from time to time by the Company for that purpose.

     "Common  Stock" means the Common  Stock,  par value $.01 per share,  of the
Company  authorized  at the  date of this  instrument  as  originally  executed.
Subject to the  provisions  of Section  2(h),  shares  issuable on conversion or
repurchase of this Security  shall include only shares of Common Stock or shares
of any class or classes of common stock resulting from any  reclassification  or
reclassifications thereof; provided, however, that if at any time there shall be
more than one such resulting class, the shares so issuable on conversion of this
Security shall include  shares of all such classes,  and the shares of each such
class then so issuable shall be  substantially in the proportion which the total
number of shares of such class resulting from all such  reclassifications  bears
to the  total  number  of shares  of all such  classes  resulting  from all such
reclassifications.

     "Determination   Date"   means,   in  the  case  of  a  dividend  or  other
distribution,  including  the  issuance  of  rights,  options  or  warrants,  to
shareholders,  the date fixed for the determination of shareholders  entitled to
receive such dividend or other  distribution and, in the case of a tender offer,
the last time that tenders could have been made pursuant to such tender offer.

     "Excess Purchase  Payment" means the product of (A) the excess,  if any, of
(i) the amount of cash plus the fair market value (as  determined  in good faith
by the Company's Board of Directors) of any non-cash  consideration  required to
be paid with respect to one share of Common Stock  acquired or to be acquired in
a tender offer made by the Company or any  subsidiary  of the Company for all or
any portion of the Common Stock over (ii) the current  market price per share as
of the last time that tenders could have been made pursuant to such tender offer
and (B) the  number of  shares  validly  tendered  and not  withdrawn  as of the
Determination Date in respect of such tender offer.

     "Trading  Day" means (i) if the Common  Stock is admitted to trading on the
Nasdaq  National  Market  or any  other  system of  automated  dissemination  of
quotations of securities  prices,  a day on which trades may be effected through
such  system;  (ii) if the Common Stock is listed or admitted for trading on the
New York Stock  Exchange or any other  national  securities  exchange,  a day on
which such  exchange is open for  business;  or (iii) if the Common Stock is not
admitted  to trading on the Nasdaq  National  Market or listed or  admitted  for
trading on any  national  securities  exchange or any other  system of automated
dissemination of quotation of securities prices, a day on which the Common Stock
is traded regular way in the over-the-counter market and for which a closing bid
and a closing asked price for the Common Stock are available.

                                       9

<PAGE>


     3. Right to Require  Repurchase.  (a) In the event that a Change in Control
(as  hereinafter  defined)  shall occur,  then the holder of this Security shall
have the right, at such holder's  option,  to require the Company to repurchase,
and upon the exercise of such right the Company shall repurchase, this Security,
or any  portion of the  principal  amount  hereof that is equal to $1,000 or any
integral multiple thereof,  on the date (the "Repurchase  Date") that is fifteen
Trading  Days after the date on which the Company  gives  notice  thereof to the
holder of this  Security,  at a purchase  price  equal to 100% of the  principal
amount  of  this  Security  to be  repurchased  plus  interest  accrued  to  the
Repurchase Date (the "Repurchase Price");  provided,  however, that installments
of  interest  on this  Security  whose  stated  maturity  is on or  prior to the
Repurchase Date shall be payable to the holder of this Security,  or one or more
predecessor Securities, registered as such on the relevant Record Date according
to their terms. At the option of the Company,  the Repurchase  Price may be paid
in cash or,  subject to the  fulfillment  by the Company of the  conditions  set
forth in Section 6 and subject to the limitations set forth therein, by delivery
of shares of Common  Stock  having a fair market  value equal to the  Repurchase
Price as described  in Section 6. The Company  agrees to give the holder of this
Security notice of any Change in Control, by facsimile transmission confirmed in
writing by  overnight  courier  service,  promptly  and in any event  within two
Trading Days of the occurrence thereof.

     (b) To exercise a repurchase right, the holder shall deliver to the Company
on or before the 10th trading day prior to the  Repurchase  Date,  together with
this  Security,  written  notice of the holder's  exercise of such right,  which
notice  shall set forth the name of the  holder,  the number of shares of Common
Stock then owned by such holder and its affiliates, the principal amount of this
Security to be repurchased  (and, if this Security is to be repurchased in part,
the portion of the principal  amount thereof to be  repurchased  and the name of
the  person in which  the  portion  thereof  to remain  outstanding  after  such
repurchase is to be registered) and a statement that an election to exercise the
repurchase  right is being made thereby,  and, in the event that the  Repurchase
Price  shall  be paid in  shares  of  Common  Stock,  the  name or  names  (with
addresses) in which the certificates for shares of Common Stock shall be issued.
Such written notice shall be irrevocable, except that the right of the holder to
convert  this  Security  (or the  portion  hereof  with  respect  to  which  the
repurchase  right is being exercised) shall continue until the close of business
on the Repurchase Date (or if the Company elects to pay the Repurchase  Price by
delivery of shares of Common  Stock,  until the close of business on the Trading
Day  immediately  preceding  the  first  delivery  of  Common  Stock in  respect
thereof).

     (c) In the event a repurchase  right shall be exercised in accordance  with
the terms  hereof,  the Company  shall pay or cause to be paid to the holder the
Repurchase Price in cash or shares of Common Stock, as provided above,  together
with accrued and unpaid interest to the Repurchase Date; provided, however, that
installments of interest that mature on or prior to the Repurchase Date shall be
payable in cash,  to the holders of this  Security,  or one or more  predecessor
Securities,  registered as such at the close of business on the relevant regular
record date.

     (d) If this Security (or portion thereof) is surrendered for repurchase and
is not so paid on or prior to the Repurchase  Date, the principal amount of this
Security (or such portion  hereof,  as the case may be) shall,  until paid, bear
interest to the extent  permitted by applicable law from the Repurchase  Date at
the rate per annum borne by this  Security,  and shall remain  convertible  into
Common Stock until the  principal of this Security (or portion  thereof,  as the
case may be) shall have been paid or duly provided for.

                                       10

<PAGE>


     (e) If this  Security  is to be  repurchased  only in  part,  it  shall  be
surrendered  to the Company at the  Designated  Office (with,  if the Company so
requires,  due  endorsement  by, or a written  instrument  of  transfer  in form
satisfactory  to the Company duly executed by, the holder hereof or his attorney
duly  authorized in writing),  and the Company shall execute and make  available
for delivery to the holder without service charge, a new Security or Securities,
containing identical terms and conditions, each in an authorized denomination in
aggregate  principal  amount  equal  to and in  exchange  for the  unrepurchased
portion of the principal of the Security so surrendered.

     (f) For purposes of this Section 3.

     (1) the term "beneficial owner" shall be determined in accordance with Rule
13d-3  promulgated  by the Securities  and Exchange  Commission  pursuant to the
Securities Exchange Act of 1934; and

     (2) a "Change in  Control"  shall be deemed to have  occurred  at the time,
after the original issuance of this Security, of:

          (i) the acquisition by any person of beneficial ownership, directly or
     indirectly,  through a purchase, merger or other acquisition transaction or
     series of transactions, of shares of capital stock of the Company entitling
     such person to exercise 50% or more of the total voting power of all shares
     of capital stock of the Company entitled to vote generally in the elections
     of  directors  (any  shares of  voting  stock of which  such  person is the
     beneficial owner that are not then outstanding being deemed outstanding for
     purposes of calculating such percentage) other than any such acquisition by
     the Company or any employee benefit plan of the Company; or

          (ii) any  consolidation  or merger of the  Company  with or into,  any
     other person, any merger of another person with or into the Company, or any
     conveyance,   transfer,   sale,  lease  or  other  disposition  of  all  or
     substantially  all of the assets of the  Company to another  person  (other
     than  (a)  any  such   transaction   (x)  which  does  not  result  in  any
     reclassification,  conversion,  exchange  or  cancellation  of  outstanding
     shares of Common  Stock and (y)  pursuant to which  holders of Common Stock
     immediately  prior to such  transaction  have the  entitlement to exercise,
     directly or indirectly, 50% or more of the total voting power of all shares
     of capital stock entitled to vote generally in the election of directors of
     the continuing or surviving person  immediately  after such transaction and
     (b) any  merger  which is  effected  solely to change the  jurisdiction  of
     incorporation of the Company and results in a reclassification,  conversion
     or exchange of  outstanding  shares of Common  Stock into solely  shares of
     common stock);

provided, however, that a Change in Control shall not be deemed to have occurred
if the  Closing  Price  for any  five  Trading  Days  within  the  period  of 10
consecutive  Trading Days (x) ending  immediately after the later of the date of
the Change in Control  or the date of the public  announcement  of the Change in
Control  (in the case of a Change in  Control  under  Clause  (i)  above) or (y)
ending  immediately prior to the date of the Change in Control (in the case of a
Change in Control  under  Clause (ii)  above)  shall equal or exceed 105% of the
Conversion Price in effect on each such Trading Day.

                                       11

<PAGE>


     4. Events of Default.  (a) "Event of Default",  wherever used herein, means
any one of the following  events  (whatever the reason for such Event of Default
and whether it shall be voluntary or  involuntary or be effected by operation of
law or pursuant to any judgment, decree or order of any court or any order, rule
or regulation of any administrative or governmental body):

          (1) default in the payment of any interest  upon this Security when it
     becomes due and payable, and continuance of such default for a period of 30
     days; or

          (2) default by the Company in the  performance  of its  obligations in
     respect of any  conversion  of this  Security  (or any  portion  hereof) in
     accordance with Section 2; or

          (3)  failure by the  Company to give any notice of a Change of Control
     required to be delivered in accordance with Section 3(a); or

          (4) default in the performance, or breach, of any material covenant or
     warranty of the Company herein (other than a covenant or warranty a default
     in the performance or breach of which is specifically  dealt with elsewhere
     in this  Section  4(a)) and  continuance  of such  default  or breach for a
     period of 30 days after there has been given,  by  registered  or certified
     mail,  to the  Company  by the  holder of this  Security  a written  notice
     specifying  such  default or breach and  requiring  it to be  remedied  and
     stating that such notice is a "Notice of Default" hereunder; or

          (5) a default  under any bond,  debenture,  note or other  evidence of
     indebtedness  for money  borrowed by the Company,  or under any  agreement,
     mortgage,  indenture  or  instrument  under which there may be issued or by
     which there may be secured or evidenced any indebtedness for money borrowed
     by the  Company,  with a  principal  amount then  outstanding  in excess of
     $1,000,000,  whether  such  indebtedness  now exists or shall  hereafter be
     created,  which default shall  constitute a failure to pay the principal of
     such  indebtedness  (in whole or in any part greater than  $1,000,000) when
     due and payable or shall have resulted in such indebtedness (in whole or in
     any part  greater  than  $1,000,000)  becoming  or being  declared  due and
     payable prior to the date on which it would  otherwise  have become due and
     payable,  without  such  indebtedness  having  been  discharged,   or  such
     acceleration having been rescinded or annulled,  within a period of 15 days
     after there shall have been given,  by registered or certified mail, to the
     Company by the holder of this  Security a written  notice  specifying  such
     default  and  requiring  the  Company  to  cause  such  indebtedness  to be
     discharged  or cause such  acceleration  to be  rescinded  or annulled  and
     stating that such notice is a "Notice of Default" hereunder; or

          (6) the entry by a court having  jurisdiction in the premises of (A) a
     decree or order for relief in respect of the Company in an involuntary case
     or proceeding under any applicable Federal or State bankruptcy, insolvency,
     reorganization  or other similar law or (B) a decree or order adjudging the
     Company a bankrupt or insolvent,  or approving as properly filed a petition
     seeking  reorganization,  arrangement,  adjustment or  composition of or in
     respect of the  Company  under any  applicable  Federal  or State  law,  or
     appointing   a  custodian,   receiver,   liquidator,   assignee,   trustee,
     sequestrator or other similar official of the Company or of any substantial
     part of its  property,  or ordering  the winding up or  liquidation  of its
     affairs, and the

                                       12

<PAGE>


     continuance of any such decree or order for relief or any such other decree
     or order unstayed and in effect for a period of 60 consecutive days; or

          (7) the  commencement by the Company of a voluntary case or proceeding
     under   any   applicable   Federal   or   State   bankruptcy,   insolvency,
     reorganization  or other  similar law or of any other case or proceeding to
     be  adjudicated a bankrupt or insolvent,  or the consent by it to the entry
     of a decree or order for relief in respect of the Company in an involuntary
     case or  proceeding  under  any  applicable  Federal  or State  bankruptcy,
     insolvency,  reorganization  or other similar law or to the commencement of
     any bankruptcy or insolvency  case or proceeding  against it, or the filing
     by it of a petition or answer or consent seeking  reorganization or similar
     relief under any  applicable  Federal or State law, or the consent by it to
     the filing of such petition or to the  appointment of or taking  possession
     by a custodian,  receiver,  liquidator,  assignee, trustee, sequestrator or
     other  similar  official of the Company or of any  substantial  part of its
     property,  or  the  making  by it of  an  assignment  for  the  benefit  of
     creditors,  or the  admission by it in writing of its  inability to pay its
     debts  generally as they become due, or the taking of  corporate  action by
     the Company in furtherance of any such action.

     (b) If an Event of Default  (other  than an Event of Default  specified  in
Section  4(a)(6) or 4(a)(7))  occurs and is continuing,  then in every such case
the holder of this  Security  may  declare  the  principal  hereof to be due and
payable  immediately,  by a notice in writing to the Company,  and upon any such
declaration  such  principal  and all  accrued  interest  thereon  shall  become
immediately due and payable. If an Event of Default specified in Section 4(a)(6)
or 4(a)(7) occurs and is continuing,  the principal of, and accrued interest on,
this Security shall ipso facto become  immediately  due and payable  without any
declaration or other act of the holders.

     5.  Consolidation,  Merger, Etc. (a) The Company shall not consolidate with
or merge into any other person or,  directly or  indirectly,  convey,  transfer,
sell or lease  all or  substantially  all of its  properties  and  assets to any
person, and the Company shall not permit any person to consolidate with or merge
into the Company or, directly or indirectly, convey, transfer, sell or lease all
or substantially all of its properties and assets to the Company, unless:

          (1) in case the Company shall  consolidate  with or merge into another
     person or convey,  transfer,  sell or lease all or substantially all of its
     properties   and  assets  to  any  person,   the  person   formed  by  such
     consolidation  or into  which the  Company  is merged or the  person  which
     acquires  by  conveyance,  transfer  or  sale,  or  which  leases,  all  or
     substantially  all the  properties  and  assets of the  Company  shall be a
     corporation,  limited  liability  company,  partnership or trust,  shall be
     organized  and  validly  existing  under the laws of the  United  States of
     America,  any State thereof or the District of Columbia and shall expressly
     assume, by an agreement supplemental hereto,  executed and delivered to the
     holder of this  Security in form  satisfactory  to the holder,  the due and
     punctual payment of the principal of (and premium,  if any) and interest on
     this Security and the  performance  or observance of every covenant of this
     Security on the part of the Company to be performed or observed,  including
     the conversion  rights  provided herein (which shall  thereafter  relate to
     common stock of such successor,  on a basis reasonably designed to preserve
     the  economic  value to the  holder  of this  Security  of such  conversion
     rights);

                                       13

<PAGE>


          (2) immediately  after giving effect to such  transaction and treating
     any indebtedness which becomes an obligation of the Company or a subsidiary
     of the Company as a result of such  transaction  as having been incurred by
     the  Company  or  such  subsidiary  of the  Company  at the  time  of  such
     transaction, no Event of Default, and no event which, after notice or lapse
     of time or both, would become an Event of Default,  shall have happened and
     be continuing;

          (3) the  Company  has  delivered  to the  holder of this  Security  an
     officers' certificate stating that such consolidation,  merger, conveyance,
     transfer,  sale or lease and, if a  supplemental  agreement  is required in
     connection with such transaction,  such supplemental agreement, comply with
     this Section and that all conditions precedent herein provided for relating
     to such transaction have been complied with; and

          (4)  counsel  for the  Company  has  delivered  to the  holder of this
     Security an opinion of such  counsel  with  respect to such  consolidation,
     merger,  conveyance,  transfer,  sale  or  lease,  and  if  a  supplemental
     agreement  is  required  in   connection   with  such   transaction,   such
     supplemental  agreement,  which  opinion  shall be, in form and  substance,
     reasonably acceptable to such holder and its counsel.

     (b) Upon any  consolidation  of the Company  with, or merger of the Company
into,  any other  person or any  conveyance,  transfer,  sale or lease of all or
substantially all of the properties and assets of the Company in accordance with
Section 5(a), the successor  person formed by such  consolidation  or into which
the Company is merged or to which such  conveyance,  transfer,  sale or lease is
made shall succeed to, and be substituted  for, and may exercise every right and
power of,  the  Company  under  this  Security  with the same  effect as if such
successor person had been named as the Company herein, and thereafter, except in
the case of a lease, the predecessor person shall be relieved of all obligations
and covenants under this Security.

     6.  Payment  in Stock.  (a) The  Company  may elect to pay any  amount  due
hereunder  in respect  of  interest  or  Repurchase  Price in respect  hereof by
delivery of shares of Common Stock if and only if the following  conditions have
been satisfied:

     (1) Any such payment shall be made in five equal  installments,  on each of
the five consecutive  Trading Days ending on and including the third Trading Day
immediately preceding the date when cash payment would otherwise be due, and the
shares of Common Stock  deliverable  in payment of each such  installment  shall
have a fair market value as of the date of such installment of not less than 20%
of the amount of such payment due hereunder. For purposes of this Section 6, the
fair market value of shares of Common Stock shall be equal to 95% of the Closing
Price for the immediately preceding Trading Day;

     (2) In the event any shares of Common Stock to be issued in respect of such
amount due  hereunder  require  registration  under any Federal  securities  law
before  such shares may be freely  transferrable  without  being  subject to any
transfer  restrictions  under the  Securities  Act of 1933 upon  issuance,  such
registration  shall have been completed and shall have become effective prior to
the date of the first such installment;

                                       14

<PAGE>


     (3) In the event any shares of Common Stock to be issued in respect of such
amount due hereunder  require  registration with or approval of any governmental
authority under any State law or any other Federal law before such shares may be
validly  issued or delivered upon issuance,  such  registration  shall have been
completed or have become  effective and such approval  shall have been obtained,
in each case, prior to the date of the first such installment;

     (4) The shares of Common  Stock  deliverable  in payment of such amount due
hereunder  shall have been approved for quotation in the Nasdaq  National Market
immediately prior to the date of the first such installment;

     (5) All shares of Common  Stock  deliverable  in payment of such amount due
hereunder  shall,  upon  issue,  be duly and  validly  issued and fully paid and
non-assessable and free of any preemptive rights; and

     (6) In respect of each such payment date,  the Company shall have given the
holder of this  Security not less than 10 nor more than 15 Trading  Days' notice
of its election to effect payment in respect of such payment date by delivery of
shares of Common  Stock;  provided  that any such  notice in  respect of amounts
payable on a Repurchase Date shall accompany the Company's notice of a Change of
Control relating thereto.

     If all of the  conditions  set forth in this Section 6(a) are not satisfied
in accordance  with the terms  thereof,  any such amount due hereunder  shall be
paid by the Company only in cash.

     Notwithstanding  the foregoing,  at no time will the Company deliver shares
of Common Stock to any holder in  satisfaction  of an obligation to pay interest
or  Repurchase  Price if the number of shares so  delivered,  together  with the
number of shares of Common Stock owned (or deemed for bank  regulatory  purposes
to be owned) by such holder and its  affiliates as  theretofore  notified to the
Company  (in a notice  delivered  not less than five  Trading  Days prior to the
relevant interest payment date, in the case of interest,  or as set forth in the
election  of holder to require  repurchase,  in the case of  Repurchase  Price),
represent more than 4.9% of the Common Stock then outstanding. If the limitation
set forth in the  previous  sentence  would  apply to any payment of interest or
Repurchase  Price,  the Company may elect (by notice to the holder delivered not
less than three Trading Days prior to the relevant interest payment date, in the
case of interest,  or not less than eight  Trading Days prior to the  Repurchase
Date, in the case of  Repurchase  Price) to satisfy a portion of such payment in
shares of Common Stock (up to the maximum number of shares  permitted  under the
limitation set forth in the previous sentence) and the balance in cash.

     (b) Any  issuance of shares of Common  Stock in respect of any  installment
due  hereunder  pursuant to this Section 6 shall be deemed to have been effected
immediately  prior to the  close of  business  on the date of  delivery  of such
installment  and the person or persons in whose name or names any certificate or
certificates  for shares of Common  Stock shall be issuable  upon such  delivery
shall be deemed to have  become on such date the  holder or holders of record of
the shares represented thereby; provided,  however, that in case any installment
shall be due on a date when the stock  transfer  books of the  Company  shall be
closed,  the  person  or  persons  in whose  name or names  the  certificate  or
certificates for such shares are to be issued shall be deemed to have become the
record holder or holders  thereof for all purposes at the opening of business on
the next succeeding day on

                                       15

<PAGE>


which such stock transfer books are open. No payment or adjustment shall be made
for  dividends or  distributions  on any Common  Stock  issued  pursuant to this
Section 6 declared prior to the relevant delivery date.

     (c) No  fractions  of shares shall be issued upon payment made in shares of
Common Stock in respect of this  Security.  Instead of any  fractional  share of
Common Stock which would otherwise be so issuable,  the Company will round up to
the next higher whole share.

     (d) Any issuance and  delivery of  certificates  for shares of Common Stock
pursuant to this  Section 6 shall be made  without  charge to the holder of this
Security for such certificates or for any tax or duty in respect of the issuance
or  delivery  of  such  certificates  or  the  securities  represented  thereby;
provided, however, that the Company shall not be required to pay any tax or duty
which may be payable in respect of any  transfer  involved  in the  issuance  or
delivery of certificates for shares of Common Stock in a name other than that of
the holder of this  Security,  and no such  issuance or  delivery  shall be made
unless and until the person requesting such issuance or delivery has paid to the
Company  the  amount  of  any  such  tax or  duty  or  has  established,  to the
satisfaction of the Company, that such tax or duty has been paid.

     7.  Other.  (a) No  provision  of this  Security  shall alter or impair the
obligation  of the  Company,  which is absolute  and  unconditional,  to pay the
principal  of,  premium,  if any,  and  interest on this  Security at the times,
places and rate,  and in the coin or currency,  herein  prescribed or to convert
this Security as herein provided.

     (b) The Company will give prompt  written  notice to the holder of Security
of any change in the location of the Designated Office.

     (c) The transfer of this Security is registrable  on the Security  Register
of the Company upon surrender of this Security for  registration  of transfer at
the Designated Office,  duly endorsed by, or accompanied by a written instrument
of transfer in form  satisfactory  to the Company  duly  executed by, the holder
hereof or his attorney duly authorized in writing, and thereupon one or more new
Securities,  of authorized  denominations  and for the same aggregate  principal
amount,  will be  issued  to the  designated  transferee  or  transferees.  Such
Securities are issuable only in registered form without coupons in denominations
of $1,000 and any integral multiple thereof. No service charge shall be made for
any such registration of transfer,  but the Company may require payment of a sum
sufficient to recover any tax or other governmental charge payable in connection
therewith.  Prior to due  presentation  of this  Security  for  registration  of
transfer, the Company and any agent of the Company may treat the person in whose
name this Security is registered as the owner thereof for all purposes,  whether
or not this  Security  be  overdue,  and  neither the Company nor any such agent
shall be affected by notice to the contrary.

     Notwithstanding any other provision of this Security, this Security and the
shares of Common Stock issuable upon  conversion  hereof may only be transferred
by the holder of this  Security (a) in the case of the Common  Stock only,  in a
widely  dispersed  registered  public  offering;  (b) to one or more  accredited
investors,  in one or more  transactions,  any one of whom, after such purchase,
would  hold not more than 2 % of the  shares of Common  Stock  then  outstanding
(assuming conversion of any portion of this Security so transferred); (c) to any
person or entity that already controls more

                                       16

<PAGE>


than 50% of the voting securities of the Company prior to such transfer;  or (d)
in a transaction  that complies with the volume and manner of sale  restrictions
of Rule 144 under the Securities  Act of 1933.  The holder of this Security,  by
acceptance thereof,  shall be deemed to have agreed to the foregoing restriction
on transfers.












                                       17


<PAGE>


     (D) THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE
LAWS OF THE STATE OF NEW YORK, UNITED STATES OF AMERICA.

     IN WITNESS  WHEREOF,  the  Company  has  caused  this  Security  to be duly
executed under its corporate seal.

Dated: September __, 1998

                                             CELGENE CORPORATION

                                             By:
                                                --------------------------------
                                                Name:
                                                Title:



Attest:



- --------------------------------
Name:
Title:




<PAGE>



                    ELECTION OF HOLDER TO REQUIRE REPURCHASE

     1. Pursuant to Section 3(a) of this Security, the undersigned hereby elects
to have all or a portion of this Security repurchased by the Company.

     2. The undersigned hereby directs the Company to pay [choose one] (a) it or
(b)  Name:  _______________________;   address:  _____________________;   Social
Security or Other Taxpayer Identification Number, if any: ___________________,in
amount in cash or, at the Company's  election  (subject to the  limitations  set
forth in the Security)  Common Stock valued as set forth in the Security,  equal
to 100 % of the principal  amount to be repurchased  (as set forth below),  plus
interest accrued to the Repurchase Date, as provided herein.

                                            Dated:
                                                  ------------------------------

                                                  ------------------------------
                                                            Signature

Number of shares of Common Stock
owned by the holder and its affiliates:
                                       ------------------------------

Principal amount to be repurchased
(an integral multiple of $1,000):
                                       ------------------------------

Remaining principal amount following such repurchase
(not less than $1,000):
                                       ------------------------------

NOTICE:  The signature to the foregoing  Election must correspond to the name as
written upon the face of this Security in every particular,  without  alteration
or any change whatsoever.

                                CONVERSION NOTICE

     The undersigned  holder of this Security hereby  irrevocably  exercises the
option to convert this Security,  or any portion of the principal  amount hereof
(which is an  integral  multiple  of $1,000)  below  designated,  into shares of
Common Stock  (subject to the  limitation  set forth in the second  paragraph of
Section 2(a) of the Security) in accordance with the terms of this Security, and
directs that such shares,  together  with a check in payment for any  fractional
share and any Security  representing any unconverted principal amount hereof, be
delivered to and be registered in the name of the undersigned unless a different
name has been indicated below. If shares of Common Stock or Securities are to be
registered in the name of a person other than the  undersigned,  the undersigned
will pay all transfer taxes payable with respect thereto. Any amount required to
be paid by the undersigned on account of interest accompanies this Security.


<PAGE>


Dated:
      ------------------------------


                                                  ------------------------------
                                                             Signature

Number of shares of Common Stock
owned by the holder and its affiliates:
                                       ------------------------------

If  shares  or  Securities  are  to be    If only a portion of the Securities is
registered  in the  name  of a  person    to be converted, please indicate:
other than the  holder,  please  print
such person's name and address:




                                          1.   Principal amount to be converted:

                                               $

    ------------------------------
                 Name

                                          2.   Principal amount and denomination
                                               of     Security      representing
                                               unconverted  principal  amount to
                                               be issued:

    ------------------------------
                Address

                                          Amount: $________

                                          Denominations: $________
                                          (any integral multiple of $1,000)
    ------------------------------

Social   Security  or  other  Taxpayer
Identification Number, if any





                                                                   EXHIBIT 10.21

                          REGISTRATION RIGHTS AGREEMENT

     REGISTRATION  RIGHTS  AGREEMENT,  dated as of September  16,  1998,  by and
between Celgene Corporation, a Delaware corporation (the "Company"), and Warburg
Dillon Read LLC (the  "Purchaser")  entered into in connection with the issuance
of a Convertible  Note due September 16, 2003  convertible into shares of Common
Stock, par value $.01 per share ("Common Stock") of the Company.

     1.   Certain Definitions.

     For purposes of this  Registration  Rights  Agreement,  the following terms
shall have the following respective meanings:

          (a) "Commission" shall mean the Securities and Exchange Commission, or
any other  federal  agency at the time  administering  the  Exchange  Act or the
Securities Act, whichever is the relevant statute for the particular purpose.

          (b)  "Convertible  Note" shall mean the Convertible Note due September
16,  2003,  of the  Company  to be  issued  and sold to the  Purchaser,  and any
Convertible Note issued in exchange therefor or in lieu thereof.

          (c)  "Effective  Time"  shall  mean the date on which  the  Commission
declares the Shelf  Registration  effective  or on which the Shelf  Registration
otherwise becomes effective.

          (d) "Exchange Act" shall mean the Securities  Exchange Act of 1934, or
any successor thereto, as the same shall be amended from time to time.

          (e) "Issue  Date" shall mean the date on which a  Convertible  Note is
initially issued.

          (f)  The  term  "person"  shall  mean  a   corporation,   association,
partnership,   organization,   business,  individual,  government  or  political
subdivision thereof or governmental agency.

          (g) "Registration Expenses" shall have the meaning assigned thereto in
Section 4 hereof.

          (h)  "Securities  Act" shall mean the  Securities  Act of 1933, or any
successor thereto, as the same shall be amended from time to time.

          (i) "Shares"  means the shares of Common Stock  issuable upon exercise
of the Convertible Note.

          (j) "Shelf  Registration"  shall have the meaning  assigned thereto in
Section 2 hereof.


<PAGE>


     In addition,  capitalized  terms not defined  herein shall have the meaning
ascribed in the Convertible Note.

     2.   Shelf Registration of Shares.

     (a) Not later than  September  16, 1999,  the Company  shall file under the
Securities Act a "shelf"  registration  statement providing for the registration
of, and the sale on a  continuous  or  delayed  basis by the  Purchaser  of, all
Shares issuable upon conversion of the Convertible  Notes,  pursuant to Rule 415
under the  Securities  Act  and/or any  similar  rule that may be adopted by the
Commission  (the  "Shelf  Registration").  The  Company  agrees  to use its best
efforts to cause the Shelf  Registration  to become or be declared  effective no
later than 45  calendar  days after the  filing  thereof  and to keep such Shelf
Registration continuously effective for a period ending on the earliest to occur
of (i) the  second  anniversary  of the Issue  Date,  (ii)  notification  to the
Company by the Purchaser that it has sold all Shares issuable upon conversion of
the  Convertible  Notes so owned by it, or (iii) such time as the  Purchaser may
sell all of such shares  pursuant to Rule 144(k) under the  Securities  Act. The
Company  further agrees,  if necessary,  to supplement or make amendments to the
Shelf  Registration,  if  required  by the rules,  regulations  or  instructions
applicable  to  the  registration  form  used  by the  Company  for  such  Shelf
Registration  or by the Securities Act or rules and  regulations  thereunder for
shelf registration, and the Company agrees to furnish to the Purchaser copies of
any such  supplement or amendment  prior to its being used and/or filed with the
Commission,  and will not file any such  supplement  or  amendment  to which the
Purchaser reasonably objects.

     (b) Notwithstanding the foregoing, following the effectiveness of the Shelf
Registration,  the Company may, at any time,  suspend the  effectiveness of such
Shelf Registration for up to 60 days, as appropriate (a "Suspension Period"), by
giving notice to the Purchaser,  if the Company shall have  determined  that the
Company may be required to disclose any  material  corporate  development  which
disclosure  may  jeopardize a material  transaction or otherwise have a material
adverse effect on the Company. The Company will use its best efforts to minimize
the length of any Suspension Period. Notwithstanding the foregoing, no more than
one  Suspension  Period may occur  within any 180 day period.  The period of any
such  suspension of the  registration  statement shall be added to the period of
time the Company agrees to keep the Shelf Registration  effective as provided in
Section  2(a).  The Purchaser  agrees that,  upon receipt of any notice from the
Company of a  Suspension  Period,  the  Purchaser  shall  forthwith  discontinue
disposition of shares covered by the Shelf  Registration until the Purchaser (i)
is advised in writing by the Company that the use of the  applicable  prospectus
may  be  resumed,  (ii)  has  received  copies  of  a  supplemental  or  amended
prospectus,  if applicable,  and (iii) has received  copies of any additional or
supplemental  filings which are  incorporated  or deemed to be  incorporated  by
reference in such prospectus.

     3.   Registration Procedures.

     (a) In connection  with any  obligation of the Company to register  Shares,
the Company shall use its best efforts to effect or cause such  registration  to
permit the sale of the Shares by the Purchaser in  accordance  with the intended
method  or  methods  of  distribution   thereof   described  in  the  applicable
registration statement.  In connection therewith,  the Company shall, within the
time specified in Section 2 above:

          (i) prepare and file with the Commission a  registration  statement on
     any form which may be utilized  by the  Company and which shall  permit the
     disposition of the Shares in accordance with the intended method or methods
     thereof, as specified in writing by the Purchaser;

                                       2

<PAGE>


          (ii) comply with the  provisions of the Securities Act with respect to
     the disposition of all of the Shares covered by such registration statement
     in accordance with the intended methods of disposition by the Purchaser set
     forth in such registration statement;

          (iii) provide (A) the Purchaser, (B) the underwriters (which term, for
     purposes of these Registration  Rights, shall include a person deemed to be
     an underwriter within the meaning of Section 2(1.1) of the Securities Act),
     if any, thereof,  (C) the sales or placement agent, if any,  therefor,  (D)
     counsel for such  underwriters or agent,  and (E) counsel for the Purchaser
     the  opportunity  to participate  in the  preparation of such  registration
     statement,  each prospectus  included therein or filed with the Commission,
     and each amendment or supplement thereto;

          (iv) for a reasonable  period prior to the filing of such registration
     statement,  and throughout the period  specified in Section 2 hereof,  make
     available for  inspection by the parties  referred to in Section  3(a)(iii)
     above who shall  certify to the Company that they have a current  intention
     to sell the Shares  pursuant to the  registration  statement such financial
     and other  information and books and records of the Company,  and cause the
     officers,  employees,  counsel and independent certified public accountants
     of the  Company  to  respond  to such  inquiries,  as shall  be  reasonably
     necessary,  in the judgment of the respective  counsel  referred to in such
     Section,  to  conduct a  reasonable  investigation  within  the  meaning of
     Section 11 of the Securities Act; provided,  however,  that each such party
     shall be  required to  maintain  in  confidence  and not to disclose to any
     other person any information or records  provided by the Company until such
     time as (A) such information  becomes a matter of public record (whether by
     virtue of its inclusion in such  registration  statement or otherwise),  or
     (B) such person shall be required so to disclose such information  pursuant
     to the subpoena or order of any court or other governmental  agency or body
     having  jurisdiction  over the matter (subject to the  requirements of such
     order, and only after such person shall have given the Company prompt prior
     written notice of such requirement), or (C) such information is required to
     be set forth in such  registration  statement,  or the prospectus  included
     therein or in an amendment to such  registration  statement or an amendment
     or supplement to such prospectus in order that such registration statement,
     prospectus,  amendment or supplement,  as the case may be, does not contain
     an untrue  statement of a material fact or omit to state therein a material
     fact  required to be stated  therein or  necessary  to make the  statements
     therein not misleading;

          (v) promptly  notify the Purchaser,  the sales or placement  agent, if
     any, therefor and the managing underwriter or underwriters, if any, thereof
     and confirm such advice in writing, (A) when such registration statement or
     the prospectus  included therein or any prospectus  amendment or supplement
     or  post-effective  amendment  has been filed,  and,  with  respect to such
     registration statement or any post-effective  amendment,  when the same has
     become effective, (B) of any comments by the Commission and by the Blue Sky
     or securities  commissioner  or regulator of any state with respect thereto
     or any request by the  Commission  for  amendments or  supplements  to such
     registration statement or prospectus or for additional information,  (C) of
     the  issuance  by  the   Commission  of  any  stop  order   suspending  the
     effectiveness  of such  registration  statement or the  initiation or overt
     threatening  of any  proceedings  for that purpose,  (D) if at any time the
     representations  and  warranties of the Company  contemplated  by Section 5
     hereof  cease to be true and correct in all material  respects,  (E) of the
     receipt by the Company of any  notification  with respect to the suspension
     of the  qualification  of the  Shares for sale in any  jurisdiction  or the
     initiation or overt threatening of any proceeding for such purpose,  or (F)
     at any time  when a  prospectus  is  required  to be  delivered  under  the
     Securities  Act, if such  registration  statement,  prospectus,  prospectus
     amendment  or  supplement  or  post-effective  amendment,  or any  document
     incorporated by reference in any of the foregoing, contains an untrue

                                       3

<PAGE>


     statement of a material  fact or omits to state any material  fact required
     to be stated  therein  or  necessary  to make the  statements  therein  not
     misleading in light of the circumstances then existing;

          (vi) use its best  efforts  to  obtain  the  withdrawal  of any  order
     suspending  the ,  effectiveness  of  such  registration  statement  or any
     post-effective amendment thereto at the earliest practicable date;

          (vii) if requested by any managing  underwriter or  underwriters,  any
     placement  or  sales  agent or the  Purchaser,  promptly  incorporate  in a
     prospectus  supplement or  post-effective  amendment such information as is
     required by the applicable  rules and  regulations  of the Commission  that
     such  managing  underwriter  or  underwriters,  such agent or the Purchaser
     specify  should be  included  therein  relating to the terms of the sale of
     such Shares, including, without limitation, information with respect to the
     number  of  Shares  being  sold  by  the  Purchaser  or  agent  or  to  any
     underwriters,   the  name  and  description  of  the  Purchaser,  agent  or
     underwriter, the offering price of such Shares and any discount, commission
     or other compensation  payable in respect thereof, the purchase price being
     paid therefor by such  underwriters  and with respect to any other terms of
     the offering of the Shares to be sold by the  Purchaser or agent or to such
     underwriters;  and make all required filings of such prospectus  supplement
     or post-effective  amendment  promptly after notification of the matters to
     be incorporated in such prospectus supplement or post-effective amendment;

          (viii)  furnish to the Purchaser,  each  placement or sales agent,  if
     any, therefor, each underwriter, if any, thereof and the respective counsel
     referred to in Section 3(a)(iii) a copy of such  registration  statement in
     the form in which it became  effective,  each such amendment and supplement
     thereto  (in  each  case  including  all  exhibits  thereto  and  documents
     incorporated  by  reference  therein)  and such  number  of  copies of such
     registration   statement   (excluding   exhibits   thereto  and   documents
     incorporated by reference  therein unless  specifically so requested by the
     Purchaser, agent or underwriter,  as the case may be) and of the prospectus
     included  in  such  registration  .statement  (including  each  preliminary
     prospectus and any summary prospectus), in conformity with the requirements
     of the Securities Act, and such other documents,  as the Purchaser,  agent,
     if any,  and  underwriter,  if any,  may  reasonably  request  in  order to
     facilitate  the  offering  and  disposition  of  the  Shares  owned  by the
     Purchaser,   offered  or  sold  by  such  agent  or  underwritten  by  such
     underwriter  and to permit the Purchaser,  agent and underwriter to satisfy
     the prospectus delivery requirements of the Securities Act; and the Company
     hereby consents to the use of such prospectus  (including such  preliminary
     and summary  prospectus)  and any  amendment or  supplement  thereto by the
     Purchaser and by any such agent and  underwriter,  in each case in the form
     most recently provided to such party by the Company, in connection with the
     offering and sale of the Shares covered by the prospectus  (including  such
     preliminary and summary prospectus) or any supplement or amendment thereto;

          (ix) use its best  efforts to (A) register or qualify the Shares to be
     included in such registration  statement under such securities laws or blue
     sky laws of such jurisdictions as the Purchaser and each placement or sales
     agent, if any,  therefor and underwriter,  if any, thereof shall reasonably
     request, (B) keep such registrations or qualifications in effect and comply
     with  such  laws so as to  permit  the  continuance  of  offers,  sales and
     dealings therein in such  jurisdictions  during the respective periods such
     registration  statements are required to remain  effective  under Section 2
     above and for so long as may be  necessary  to enable the  Purchaser or any
     agent or underwriter  to complete its  distribution  of Shares  pursuant to
     such  registration  statement and (C) take any and all other actions as may
     be reasonably  necessary or advisable to enable the  Purchaser,  agent,  if
     any,  and  underwriter,  if any,  to  consummate  the  disposition  in such
     jurisdictions of such Shares; provided, however, that the Company

                                       4

<PAGE>


     shall not be  required  for any such  purpose  to (I)  qualify as a foreign
     corporation in any jurisdiction  wherein it would not otherwise be required
     to  qualify  but for the  requirements  of this  Section  3(a)(ix)  or (II)
     consent to general service of process in any such jurisdiction;

          (x) use its best  efforts to obtain the  consent or  approval  of each
     governmental  agency or authority,  whether federal,  state or local, which
     may be required to effect the Shelf Registration or the offering or sale in
     connection  therewith or to enable the Purchaser to offer, or to consummate
     the disposition of, its Shares;

          (xi)  cooperate with the Purchaser and the managing  underwriters,  if
     any, to facilitate the timely  preparation and delivery of any certificates
     representing  Shares  to be sold,  which  certificates  shall  be  printed,
     lithographed  or engraved,  or produced by any combination of such methods,
     and which  shall  not,  once sold  under the Shelf  Registration,  bear any
     restrictive legends; and, in the case of an underwritten  offering,  enable
     such Shares to be in such denominations and registered in such names as the
     managing  underwriters  may request at least two business days prior to any
     sale of the Shares:

          (xii)  enter  into  one or more  underwriting  agreements,  engagement
     letters, agency agreements or similar agreements, as appropriate, including
     (without  limitation)  customary provisions relating to indemnification and
     contribution,  and take such other actions in connections  therewith as the
     Purchaser shall  reasonably  request in order to expedite or facilitate the
     disposition of the Shares;

          (xiii)  notify the Purchaser in writing of any proposal by the Company
     to amend or waive any provision of these  Registration  Rights  pursuant to
     Section  7(g)  hereof  and of any  amendment  or waiver  effected  pursuant
     thereto,  each of which  notices shall contain the text of the amendment or
     waiver proposed or effected, as the case may be;

          (xiv)  in the  event  that  any  broker-dealer  registered  under  the
     Exchange Act shall  underwrite  any Shares or participate as a member of an
     underwriting  syndicate  or selling  group or "assist in the  distribution"
     (within  the meaning of the Rules of Fair  Practice  and the By-Laws of the
     National Association of Securities Dealers, Inc. ("NASD")) thereof, whether
     as an  underwriter,  a  placement  or sales  agent or a broker or dealer in
     respect thereof, or otherwise,  assist such broker-dealer in complying with
     the requirements of such Rules and By-Laws, including,  without limitation,
     by providing such  information to such  broker-dealer as may be required in
     order for such  broker-dealer  to comply with the requirements of the Rules
     of Fair Practice of the NASD;

          (xv)  comply  with  all  applicable   rules  and  regulations  of  the
     Commission, and make generally available to its security holders as soon as
     practicable  but in any event  not later  than  eighteen  months  after the
     effective date of such registration  statement, an earning statement of the
     Company and its subsidiaries complying with Section 1l(a) of the Securities
     Act (including, at the option of the Company, Rule 158 thereunder); and

          (xvi) use its best efforts to have the Shares  approved for trading on
     the Nasdaq National Market.

     (b) In the event that the Company  would be  required,  pursuant to Section
3(a)(v)(F) above, to notify the Purchaser, the placement or sales agent, if any,
therefor and the  managing  underwriters,  if any,  thereof,  the Company  shall
without delay prepare and furnish to the  Purchaser,  to each placement or sales
agent,

                                       5

<PAGE>


if any,  and to each  underwriter,  if any, a  reasonable  number of copies of a
prospectus supplemented or amended in form and substance reasonably satisfactory
to them,  so that,  as  thereafter  delivered  to  purchasers  of  Shares,  such
prospectus  shall not contain an untrue  statement of a material fact or omit to
state a material  fact  required to be stated  therein or  necessary to make the
statements  therein not misleading in light of the circumstances  then existing.
The Purchaser  agrees that upon receipt of any notice from the Company  pursuant
to Section  3(a)(v)(F)  hereof,  the Purchaser shall  forthwith  discontinue the
disposition of Shares pursuant to the registration  statement applicable to such
Shares  until the  Purchaser  shall  have  received  copies of such  amended  or
supplemented prospectus,  and if so directed by the Company, the Purchaser shall
deliver  to the  Company  (at the  Company's  expense)  all  copies,  other than
permanent  file copies,  then in the  Purchaser's  possession of the  prospectus
covering such Shares at the time of receipt of such notice.

     (c) The Company may require the  Purchaser  to furnish to the Company  such
information  regarding  the  Purchaser and the  Purchaser's  intended  method of
distribution  of the  Shares as the  Company  may from  time to time  reasonably
request in writing,  but only to the extent that such information is required in
order to comply with the  Securities  Act.  The  Purchaser  agrees to notify the
Company as promptly as  practicable  of any  inaccuracy or change in information
previously furnished by the Purchaser to the Company or of the occurrence of any
event in  either  case as a result  of which  any  prospectus  relating  to such
registration  contains or would  contain an untrue  statement of a material fact
regarding the Purchaser or the  Purchaser's  intended  method of distribution of
such Shares or omits to state any material  fact  regarding the Purchaser or the
Purchaser's intended method of distribution of such Shares required to be stated
therein or necessary to make the  statements  therein not misleading in light of
the  circumstances  then  existing,  and  promptly to furnish to the Company any
additional  information  required to correct and update any previously furnished
information or required so that such prospectus shall not contain,  with respect
to the Purchaser or the  distribution of such Shares,  an untrue  statement of a
material fact or omit to state a material fact required to be stated  therein or
necessary  to make  the  statements  therein  not  misleading  in  light  of the
circumstances  then  existing.  The Purchaser  agrees that upon  delivering  any
notice to the  Company  pursuant  to this  Section  3(c),  the  Purchaser  shall
forthwith  discontinue the  disposition of Shares  pursuant to the  registration
statement  applicable  to such Shares until the  Purchaser  shall have  received
copies of such  amended or  supplemented  prospectus,  and if so directed by the
Company,  the Purchaser shall deliver to the Company (at the Company's  expense)
all copies, other than permanent file copies then in the Purchaser's  possession
of the prospectus covering such Shares at the time of receipt of such notice.

     4.   Registration Expenses.

     The  Company  agrees to bear and to pay or cause to be paid  promptly  upon
request being made therefor all expenses  incident to the Company's  performance
of or  compliance  with these  Registration  Rights as they  relate to the Shelf
Registration,  including,  without  limitation,  (i) all Commission and any NASD
registration  and  filing  fees and  expenses,  (ii) all  fees and  expenses  in
connection with the  qualification of the Shares for offering and sale under the
State  securities  and blue sky laws  referred  to in Section  3(a)(ix)  hereof,
including  reasonable  fees and  disbursements  of counsel for the  placement or
sales agent or underwriters in connection  with such  qualifications,  (iii) all
fees and expenses in  connection  with the approval for trading of the Shares on
the Nasdaq  National  Market,  (iv) all  expenses  relating to the  preparation,
printing,  distribution and reproduction of each registration statement required
to be  filed  hereunder,  each  prospectus  included  therein  or  prepared  for
distribution pursuant hereto, each amendment or supplement to the foregoing, the
certificates  representing  the Shares and all other documents  relating hereto,
(v) internal expenses (including,  without limitation, all salaries and expenses
of the Company's officers and employees  performing legal or accounting duties),
and (vi) fees,  disbursements and expenses of counsel and independent  certified
public  accountants  of the Company  (including  the expenses of any opinions or
"cold comfort" letters required by or incident to such

                                       6

<PAGE>


performance  and  compliance)   (collectively,   the  "Registration  Expenses").
Notwithstanding  the  foregoing,  the  Purchaser  shall pay all agency  fees and
commissions and underwriting discounts and commissions  attributable to the sale
of the Shares and the fees and disbursements of any counsel or other advisors or
experts retained by the Purchaser.

     5.   Representations and Warranties.

     The Company  represents  and warrants to, and agrees  with,  the  Purchaser
that:

          (a) Each  registration  statement  covering Shares and each prospectus
(including any preliminary or summary prospectus) contained therein or furnished
pursuant to Section  3(a)(viii) hereof and any further amendments or supplements
to any such registration  statement or prospectus,  when it becomes effective or
is  filed  with the  Commission,  as the  ease  may be,  and,  in the case of an
underwritten  offering  of  Shares,  at  the  time  of  the  closing  under  the
underwriting agreement relating thereto will conform in all material respects to
the requirements of the Securities Act, and will not contain an untrue statement
of a  material  fact or omit to state a  material  fact  required  to be  stated
therein or necessary to make the statements  therein not misleading;  and at all
times subsequent to the Effective Time when a prospectus would be required to be
delivered  under the  Securities  Act, other than from (i) such time as a notice
has been given to the Purchaser pursuant to Section 3(a)(v)(F) hereof until (ii)
such  time as the  Company  furnishes  an  amended  or  supplemented  prospectus
pursuant to Section  3(b) hereof,  each such  registration  statement,  and each
prospectus  (including any summary  prospectus)  contained  therein or furnished
pursuant to Section  3(a)(viii)  hereof,  as then amended or supplemented,  will
conform in all material  respects to the requirements of the Securities Act, and
will not  contain  an untrue  statement  of a  material  fact or omit to state a
material fact required to be stated  therein or necessary to make the statements
therein  not  misleading  in the  light  of  the  circumstances  then  existing;
provided,  however, that this representation and warranty shall not apply to any
statements or omissions made in reliance upon and in conformity with information
furnished in writing to the Company by the Purchaser expressly for use therein.

          (b) Any documents incorporated by reference in any prospectus referred
to in Section 5(a) hereof,  when they become or became  effective or are or were
filed with the Commission, or if amended, when amended, as the case may be, will
conform  or  conformed  in all  material  respects  to the  requirements  of the
Exchange  Act,  and none of such  documents  will contain or contained an untrue
statement  of a material  fact or will omit or omitted to state a material  fact
required to be stated  therein or necessary to make the  statements  therein not
misleading;  provided,  however, that this representation and warranty shall not
apply to any  statements  or omissions  made in reliance  upon and in conformity
with information  furnished in writing to the Company by the Purchaser expressly
for use therein.

     6.   Indemnification.

          (a)  Indemnification  by the Company.  Upon the registration of Shares
pursuant to Section 2 hereof,  and in  consideration  of the  agreements  of the
Purchaser  contained  herein,  and as an inducement to the Purchaser to purchase
the Convertible Notes, the Company shall, and it hereby agrees to, indemnify and
hold harmless the Purchaser and each person who  participates  as a placement or
sales agent or as an  underwriter in any offering or sale of such Shares against
any losses,  claims,  damages or  liabilities,  joint or  several,  to which the
Purchaser  or any  such  agent or  underwriter  may  become  subject  under  the
Securities  Act or  otherwise,  insofar  as  such  losses,  claims,  damages  or
liabilities  (or actions in respect  thereof)  arise out of or are based upon an
untrue statement or alleged untrue statement of a material fact contained in any
registration  statement  under  which  such  Shares  were  registered  under the
Securities Act, or any preliminary,

                                       7

<PAGE>


final or summary prospectus contained therein or furnished by the Company to the
Purchaser,  agent or  underwriter,  or any amendment or supplement  thereto,  or
arise out of or are based upon the omission or alleged omission to state therein
a  material  fact  required  to be  stated  therein  or  necessary  to make  the
statements  therein not misleading,  and the Company shall, and it hereby agrees
to,  reimburse the Purchaser,  such agent and such  underwriter for any legal or
other expenses  reasonably  incurred by them in connection with investigating or
defending  any such action or claim as such  expenses  are  incurred;  provided,
however,  that the  Company  shall not be liable to any such  person in any such
case to the extent that any such loss, claim,  damage or liability arises out of
or is based upon an untrue  statement or alleged untrue statement or omission or
alleged omission made in such registration statement,  or preliminary,  final or
summary  prospectus,  or  amendment  or  supplement  in  reliance  upon  and  in
conformity  with  written  information  furnished  to the Company by such person
expressly for use therein; provided further, however, that the Company shall not
be liable to any such Person if such Person  failed to deliver a  prospectus  in
the form most  recently  provided by the Company  (including  any  amendments or
supplements thereto previously provided by the Company), in any such case to the
extent that any loss, claim,  damage or liability arises out of or is based upon
an untrue  statement or an omission  which was  corrected in such most  recently
furnished prospectus (including any such amendments or supplements).

          (b)  Indemnification by the Purchaser and any Agents and Underwriters.
The  Company  may  require,  as a  condition  to  including  any  Shares  in any
registration  statement  filed pursuant to Section 2 hereof and to entering into
an underwriting  agreement, if any, with respect thereto, that the Company shall
have received an undertaking  reasonably  satisfactory  to it from the Purchaser
and from each  underwriter,  if any, named in any such  underwriting  agreement,
severally  and not  jointly,  to (i)  indemnify  and hold  harmless  the Company
against  any losses,  claims,  damages or  liabilities  to which the Company may
become subject,  under the Securities Act or otherwise,  insofar as such losses,
claims,  damages or liabilities (or actions in respect  thereof) arise out of or
are based upon an untrue  statement  or alleged  untrue  statement of a material
fact contained in such  registration  statement,  or any  preliminary,  final or
summary  prospectus  contained  therein  or  furnished  by  the  Company  to the
Purchaser,  agent or  underwriter,  or any amendment or supplement  thereto,  or
arise out of or are based upon the omission or alleged omission to state therein
a  material  fact  required  to be  stated  therein  or  necessary  to make  the
statements  therein not misleading,  in each case to the extent, but only to the
extent,  that such untrue  statement or alleged untrue  statement or omission or
alleged  omission  was made in  reliance  upon and in  conformity  with  written
information  furnished to the Company by the Purchaser or underwriter  expressly
for use therein,  and (ii) reimburse the Company for any legal or other expenses
reasonably incurred by the Company in connection with investigating or defending
any such action or claim as such expenses are incurred.

          (c) Notices of Claims.  Etc.  Promptly after receipt by an indemnified
party under subsection (a) or (b) above of written notice of the commencement of
any action, such indemnified party shall, if a claim in respect thereof is to be
made against an indemnifying party pursuant to the indemnification provisions of
or contemplated by this Section 6, notify such indemnifying  party in writing of
the commencement of such action;  but the omission so to notify the indemnifying
party  shall  not  relieve  it  from  any  liability  which  it may  have to any
indemnified  party  other  than  under  the  indemnification  provisions  of  or
contemplated  by Section 6(a) or 6(b)  hereof.  In case any such action shall be
brought against any indemnified party and it shall notify an indemnifying  party
of the  commencement  thereof,  such  indemnifying  party  shall be  entitled to
participate  therein  and, to the extent that it shall  wish,  jointly  with any
other indemnifying party similarly notified, to assume the defense thereof, with
counsel  satisfactory to such indemnified  party (who shall not, except with the
consent of the indemnified  party, be counsel to the indemnifying  party),  and,
after  notice  from  the  indemnifying  party to such  indemnified  party of its
election so to assume the defense thereof,  such indemnifying party shall not be
liable to such indemnified party for any legal expenses of other counsel or any

                                       8

<PAGE>


other expenses, in each case subsequently incurred by such indemnified party, in
connection   with  the  defense   thereof   other  than   reasonable   costs  of
investigation.

          (d) Contribution. Each party hereto agrees that, if for any reason the
indemnification  provisions  contemplated  by Section  6(a) or Section  6(b) are
unavailable to or insufficient to hold harmless an indemnified  party in respect
of any losses,  claims,  damages or liabilities (or actions in respect  thereof)
referred to  .therein,  then each  indemnifying  party shall  contribute  to the
amount  paid or payable by such  indemnified  party as a result of such  losses,
claims,  damages  or  liabilities  (or  actions  in  respect  thereof)  in  such
proportion  as is  appropriate  to reflect  the  relative  benefits  received by
indemnified  party on the one hand and the indemnifying  party on the other from
any  offering  of the  Shares.  If,  however,  the  allocation  provided  by the
immediately  preceding  sentence is not  permitted by  applicable  law or if the
indemnified party failed to give the notice required under subsection (c) above,
then each indemnifying  party shall contribute to such amount paid or payable by
such indemnified  party in such proportion as is appropriate to reflect not only
such relative benefits but also the relative fault of the indemnifying party and
the  indemnified  party in connection  with the  statements  or omissions  which
resulted in such losses,  claims,  damages or liabilities (or actions in respect
thereof), as well as any other relevant equitable  considerations.  The relative
benefits  received by the Company on the one hand and the Purchaser on the other
shall be  deemed  to be in the  same  proportion  as the  total  purchase  price
received  by the Company  upon  issuance  of the  Convertible  Note bears to the
difference  between the proceeds from the offering of the Shares received by the
Purchaser and such purchase price. The relative fault of such indemnifying party
and  indemnified  party shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or omission or
alleged  omission to state a material  fact relates to  information  supplied by
such indemnifying  party or by such indemnified  party, and the parties relative
intent,  knowledge,  access to information and opportunity to correct or prevent
such  statement or omission.  The parties hereto agree that it would not be just
and equitable if contributions  pursuant to this Section 6(d) were determined by
pro rata allocation  (even if the Purchaser or any agents or underwriters or all
of them were  treated as one entity for such  purpose) or by any other method of
allocation which does not take account of the equitable  considerations referred
to in this Section 6(d). The amount paid or payable by an indemnified party as a
result of the losses,  claims,  damages,  or liabilities  (or actions in respect
thereof) referred to above shall be deemed to include any legal or other fees or
expenses  reasonably  incurred  by such  indemnified  party in  connection  with
investigating  or  defending  any such  action  or  claim.  Notwithstanding  the
provisions  of this  Section  6(d),  the  Purchaser  shall  not be  required  to
contribute  any amount in excess of the amount by which the dollar amount of the
proceeds  received by the Purchaser from the sale of any Shares (after deducting
any fees,  discounts and commissions  applicable  thereto) exceeds the amount of
any damages which the Purchaser has otherwise  been required to pay by reason of
such untrue or alleged untrue statement or omission or alleged omission,  and no
underwriter  shall be required to contribute  any amount in excess of the amount
by which the total price at which the Shares  underwritten by it and distributed
to the public were offered to the public exceeds the amount of any damages which
such  underwriter has otherwise been required to pay by reason of such untrue or
alleged untrue  statement or omission or alleged  omission.  No person guilty of
fraudulent  misrepresentation  (within  the  meaning  of  Section  1 l(f) of the
Securities  Act) shall be entitled to  contribution  from any person who was not
guilty of such fraudulent  misrepresentation.  Any underwriters'  obligations in
this Section 6(d) to contribute  shall be several in proportion to the principal
amount of Shares underwritten by them and not joint.

          (e) The  obligations  of the Company  under this Section 6 shall be in
addition to any liability which the Company may otherwise have and shall extend,
upon the same terms and Conditions, to each officer, director and partner of the
Purchaser,  any agent and any underwriter and each person,  if any, who controls
the Purchaser or any agent or  underwriter  within the meaning of the Securities
Act;  and the  obligations  of the  Purchaser  and any agents  and  underwriters
contemplated by this Section 6 shall be in addition to any

                                       9

<PAGE>


liability  which the Purchaser or any such agent or  underwriter,  respectively,
may otherwise have and shall extend, upon the same terms and conditions, to each
officer and director of the Company (including any person who, with his consent,
is named in any  registration  statement  as about to become a  director  of the
Company) and to each person, if any, who controls the Company within the meaning
of the Securities Act.

     7.   Miscellaneous.

          (a) No  Inconsistent  Agreements.  The Company  represents,  warrants,
covenants and agrees that it has not granted, and shall not grant,  registration
rights with respect to Shares or any other  securities which would conflict with
the terms contained in these Registration Rights.

          (b) Specific  Performance.  The parties hereto  acknowledge that there
may be no  adequate  remedy  at law if any  party  fails to  perform  any of its
obligations  hereunder and that each party may be irreparably harmed by any such
failure,  and accordingly agree that each party, in addition to any other remedy
to which it may be  entitled  at law or in equity,  shall be  entitled to compel
specific  performance  of  the  obligations  of  any  other  party  under  these
Registration  Rights  in  accordance  with the  terms  and  conditions  of these
Registration  Rights,  in any court of the  United  States or any State  thereof
having jurisdiction.

          (c) Notices.  Any notice or other communication  required or permitted
to be  given  hereunder  shall  be  deemed  effectively  given  when  personally
delivered,  telexed,  transmitted  by facsimile or mailed by pre-paid  certified
mail, return receipt requested, or by telephone when confirmed in writing by one
of the preceding methods addressed as follows (as applicable):

                  If to the Company, to:

                  Celgene Corporation
                  7 Powder Horn Drive
                  Warren, NJ 07059

                  Attention: John W. Jackson
                  Telephone Number: (732) 271-1001 '
                  Facsimile Transmission Number: (732) 805-3931

                  with a copy to:

                  Proskauer Rose LLP
                  1585 Broadway
                  New York, NY 10036

                  Attention: Robert A. Cantone, Esq.
                  Telephone Number: (212) 969-3000
                  Facsimile Transmission Number: (212) 969-2900


                                       10

<PAGE>


                  If to Warburg Dillon Read LLC, to:

                  Warburg Dillon Read LLC
                  677 Washington Blvd.
                  Stamford, CT 06901

                  Attention:    General Counsel
                                Capital Markets
                  Telephone Number: (203) 719-3000
                  Facsimile Transmission Number: (203) 719-6097

or to such other  address or number and to the attention of such other person as
either party may designate by written notice to the other party. Notice shall be
effective upon actual receipt.

          (d) Survival. The respective indemnities, agreements, representations,
warranties and each other  provision set forth in these  Registration  Rights or
made  pursuant  hereto shall remain in full force and effect  regardless  of any
investigation  (or statement as to the results  thereof) made by or on behalf of
the Purchaser,  any director,  officer or partner of the Purchaser, any agent or
underwriter  or any director,  officer or partner  thereof,  or any  controlling
person of any of the foregoing.

          (e) Law Governing.  These Registration Rights shall be governed by and
construed in accordance with the laws of the State of New York.

          (f) Headings.  The  descriptive  headings of the several  Sections and
paragraphs of these  Registration  Rights are inserted for convenience  only, do
not constitute a part of these  Registration  Rights and shall not affect in any
way the meaning or interpretation of these Registration Rights.

          (g) Entire Agreement:  Amendments.  These Registration  Rights and the
other writings referred to herein or delivered pursuant hereto which form a part
hereof  contain  the entire  understanding  of the parties  with  respect to its
subject matter.  These  Registration  Rights  supersede all prior agreements and
understandings  between the parties  with respect to its subject  matter.  These
Registration  Rights  may be  amended  and the  observance  of any term of these
Registration  Rights may be waived (either generally or in a particular instance
and either  retroactively or  prospectively)  only by a written  instrument duly
executed by the Company and the Purchaser.

          (h)  Assignment.  In connection  with.  any permitted  transfer of the
Convertible  Note or any portion thereof in a principal  amount of not less than
$1,000,000  the  Purchaser  may assign its rights  hereunder  in respect of such
Convertible Note to the transferee.  Upon such assignment the transferee  shall,
insofar as the transferred  Convertible Notes are concerned,  be entitled to all
of the rights, and be subject to all of the obligations,  of the Purchaser under
these  Registration  Rights,  and all references to the "purchaser" herein shall
thereafter be deemed to refer to the Purchaser, or such transferee,  or both, as
the circumstances warrant.

          (i)  Counterparts.  This  agreement  may be  executed  by the  parties
counterparts,  each of which  shall be  deemed to be an  original,  but all such
respective counterparts shall together constitute one and the same instrument.

                                       11

<PAGE>


     Agreed to and accepted as of the date referred to above.

                                                 CELGENE CORPORATION

                                                 By:
                                                    ----------------------------
                                                    Name:
                                                    Title:

                                                 WARBURG DILLON READ LLC

                                                 By:
                                                    ----------------------------
                                                    Name:
                                                    Title:








                                                                   EXHIBIT 10.22

                             NOTE PURCHASE AGREEMENT

                                                                 January 20,1999

To the Purchasers
listed on attached
Schedule I

Dear Sirs:

     CELGENE  CORPORATION (the "Company") wishes to confirm its arrangement with
the  Purchasers  named on Schedule I to this  Agreement  (the  "Purchasers"  and
singly each  "Purchaser")  in  connection  with the issuance to the  Purchasers,
against payment in immediately  available funds of the purchase price of 100% of
the principal  amount thereof,  of one or more senior  convertible  notes in the
form attached hereto as Exhibit A (collectively  the "Convertible  Notes") in an
aggregate principal amount of $15,000,000 and convertible initially into 833,400
fully paid and  non-assessable  shares (each a "Share") of the Company's  Common
Stock, par value $.01 per share (the "Common  Stock"),  subject to adjustment as
set forth in the Convertible Notes.

     Simultaneously  with the issuance of the Convertible Notes pursuant to this
Agreement,  the Company and the  Purchasers  have  entered  into a  Registration
Rights  Agreement,  dated  as of  the  date  hereof  (the  "Registration  Rights
Agreement"),  pursuant to which the  Company  has agreed to register  the Shares
under certain circumstances.  Any capitalized term not defined herein shall have
the meaning ascribed to such term in the Convertible Notes.

     1. AGREEMENT TO ISSUE AND ACCEPT. On the basis of the  representations  and
warranties  made by the  Company  to  induce  the  Purchasers  to  purchase  the
Convertible Notes and subject to the terms and conditions set forth herein,  the
Company will issue to each  Purchaser,  and each  Purchaser will accept from the
Company,  the Convertible Notes in the principal amount specified  opposite such
Purchaser's  name on Schedule I attached hereto at the purchase price of 100% of
the principal  amount thereof  against payment of the  above-specified  purchase
price  therefor.  The closing (the  "Closing") of the issuance and acceptance of
the Convertible  Notes against such payment shall take place on the date hereof,
at which time the Company shall deliver to each Purchaser the Convertible Notes,
against  delivery by each  Purchaser of a wire transfer of the purchase price to
the Company's account at PNC Bank New Jersey Trust, ABA No.  031000053,  benefit
Account  No.  8511074024,  for  further  credit to Account  No.  42432012020943,
Celgene Corporation, Attn: Lisa Goldhammer,  Telephone No. (732) 220-3112. If at
the  Closing  the  Company  shall fail to tender the  Convertible  Notes to each
Purchaser  as provided in this Section 1 or any of the  conditions  specified in
Section 5 shall not have been fulfilled to each Purchaser's  satisfaction,  each
Purchaser,  at its election,  shall be relieved of all further obligations under
this  Agreement,  without  thereby waiving any rights each Purchaser may have by
reason of such failure or such nonfulfillment.


<PAGE>


     2.  REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company hereby makes
the  representations  and  warranties  set  forth  on  Annex  II  hereto  to the
Purchasers.

     3.  AGREEMENTS OF PURCHASER.  Each Purchaser  covenants and agrees with the
Company that:

          (a) Such  Purchaser  will not  offer,  sell,  assign,  hypothecate  or
otherwise  transfer  the  Convertible  Notes except (i) pursuant to an effective
registration  statement under the Securities Act of 1933 (the "Act"),  (ii) to a
person you reasonably believe to be an "accredited  investor" within the meaning
of Rule 501 under the Act,  pursuant to an available  exemption under the Act or
(iii) in offshore  transactions  within the meaning and meeting the requirements
of Rule 903 under the Act.

          (b) Such  Purchaser  will not  offer,  sell,  assign,  hypothecate  or
otherwise  transfer any Shares issued upon conversion of the  Convertible  Notes
except (i) pursuant to an effective  registration  statement under the Act; (ii)
to a person you  reasonably  believe to be an "accredited  investor"  within the
meaning of Rule 501 under the Act, pursuant to an available  exemption under the
Act or (iii) in an  offshore  transaction  within the  meaning  and  meeting the
requirements of Rule 903 under the Act.

          (c) Such Purchaser is an "accredited  investor"  within the meaning of
Rule 501 under the Act.

          (d) During the period  that the Company is  prohibited  from making an
optional  redemption  under  Section  1 of the  Convertible  Note,  so long as a
Purchaser holds a Convertible  Note, such Purchaser shall not undertake any form
of short sale,  derivative or other transaction which has the effect of taking a
"short  position" in the Common  Stock of the Company to hedge such  Purchaser's
investment in the Company, provided, however, that no affiliate of any Purchaser
shall be  subject  to the  provisions  of this  subsection  3(d).  The  covenant
contained in this Section 3(d) shall be,  subject to the  limitations  contained
herein, binding on any holder of a Convertible Note.

          (e)  Each  Purchaser  represents  that at least  one of the  following
statements is an accurate representation as to each source of funds (a "Source")
to be used by such Purchaser to pay the purchase price of the Convertible  Notes
to be purchased by it hereunder:

          (i) the Source is an "insurance  company  general  account" within the
     meaning of Department of Labor  Prohibited  Transaction  Exemption  ("PTE")
     95-60  (issued  July 12,  1995)  and  there is no  employee  benefit  plan,
     treating as a single plan all plans,  maintained  by the same  employer (or
     affiliate  thereof as defined in Section  V(a)(1) of PTE 95-60) or employee
     organization,  with  respect  to which the  amount of the  general  account
     reserves and  liabilities  for all  contracts  held by or on behalf of such
     plan exceeds ten percent  (10%) of the total  reserves and  liabilities  of
     such general  account  (exclusive  of separate  account  liabilities)  plus
     surplus,  as set  forth  in the  NAIC  Annual  Statement  filed  with  such
     Purchaser's state of domicile; or

                                        2

<PAGE>


          (ii) the Source is either (a) an  insurance  company  pooled  separate
     account,  within the meaning of Prohibited  Transaction  Exemption  ("PTE")
     90-1 (issued January 29, 1990), or (b) a bank collective  investment  fund,
     within the meaning of the PTE 91-38  (issued July 12, 1991) and,  except as
     you have  disclosed  to the Company in writing  pursuant to this  paragraph
     (ii),  no employee  benefit plan or group of plans  maintained  by the same
     employer or employee  organization  beneficially  owns more than 10% of all
     assets allocated to such pooled separate  account or collective  investment
     fund; or

          (iii) the Source  constitutes  assets of an "investment  fund" (within
     the  meaning  of Part V of the  QPAM  Exemption)  managed  by a  "qualified
     professional  asset manager" or "QPAM" (within the meaning of Part V of the
     QPAM  Exemption),  no employee  benefit  plan's assets that are included in
     such  investment  fund, when combined with the assets of all other employee
     benefit  plans  established  or  maintained  by the same  employer or by an
     affiliate  (within the meaning of Section V(c)(1) of the QPAM Exemption) of
     such  employer  or by the same  employee  organization  and managed by such
     QPAM,  exceed 20% of the total  client  assets  managed  by such QPAM,  the
     conditions  of Part  I(c)  and (g) of the  QPAM  Exemption  are  satisfied,
     neither  the  QPAM  nor a  person  controlling  or  controlled  by the QPAM
     (applying  the  definition  of  "control"  in  Section  V(e)  of  the  QPAM
     Exemption)  owns a 5% or more  interest in the Company and (a) the identity
     of such QPAM and (b) the names of all employee  benefit  plans whose assets
     are included in such  investment fund have been disclosed to the Company in
     writing pursuant to this paragraph (iii); or

          (iv) the Source is a governmental plan; or

          (v) the Source is one or more employee  benefit  plans,  or a separate
     account or trust fund comprised of one or more employee benefit plans, each
     of which has been  identified  to the  Company in writing  pursuant to this
     paragraph (e); or

          (vi) the Source does not include assets of any employee  benefit plan,
     other than a plan exempt from the coverage of ERISA.

As used in this Section 3(e), the terms "employee  benefit plan",  "governmental
plan",  "party in interest" and  "separate  account"  shall have the  respective
meanings assigned to such terms in Section 3 of ERISA.

Prior to any holder of this Security  transferring this Security,  the holder of
this  Security  shall  provide  a  certificate  from  such  proposed  subsequent
transferee   wherein  such  proposed   subsequent   transferee  shall  make  the
representations made in this Section 3(e) and shall  simultaneously  deliver any
disclosure letter required under Section 3(e)(iii). Such subsequent transferee's
failure to deliver such a certificate  shall not relieve the Company from any of
the terms, covenants or conditions of this Security.

                                       3

<PAGE>


     4.  Agreements of the Company.  From and after the date of this  Agreement,
and thereafter so long as any of the Convertible Notes remain  outstanding,  the
Company  will duly  perform and  observe,  for the benefit of the holders of the
Convertible Notes, each and all of the covenants and agreements  hereinafter set
forth:

          (a) The Company shall deliver to each holder of a Convertible Note:

               i.  Quarterly  Statements  -- upon  the  earlier  of (x) when the
          Company  files  its  Form  10-Q  with  the   Securities  and  Exchange
          Commission  for a fiscal  period and (y) 50 days after the end of each
          quarterly fiscal period in each fiscal year of the Company (other than
          the last quarterly fiscal period of each such fiscal year),  duplicate
          copies of,

                    (1) a  consolidated  balance  sheet of the  Company  and its
               Subsidiaries as at the end of such quarter, and

                    (2)   consolidated   statements   of   income,   changes  in
               shareholders'  equity  and  cash  flows  of the  Company  and its
               Subsidiaries, for such quarter and (in the case of the second and
               third  quarters)  for the  portion of the fiscal year ending with
               such quarter,

               setting  forth in each case in  comparative  form the figures for
               the  corresponding  periods in the previous  fiscal year,  all in
               reasonable detail, prepared in accordance with GAAP applicable to
               quarterly  financial  statements  generally,  and  certified by a
               Senior Financial  Officer as fairly  presenting,  in all material
               respects,  the financial position of the companies being reported
               on and their  results of  operations  and cash flows,  subject to
               changes  resulting  from  year-end  adjustments,   provided  that
               delivery within the time period  specified above of copies of the
               Company's  Quarterly  Report on Form 10-Q  prepared in compliance
               with the requirements  therefor and filed with the Securities and
               Exchange  Commission  shall be deemed to satisfy the requirements
               of this Section 4(a)(i);

               ii. Annual  Statements -- upon the earlier of(x) when the Company
          files its Form 10-K with the Securities and Exchange  Commission for a
          fiscal  period and (y) 105 days after the end of each  fiscal  year of
          the Company, duplicate copies of,

                    (1) a  consolidated  balance  sheet of the  Company  and its
               Subsidiaries, as at the end of such year, and

                    (2)   consolidated   statements   of   income,   changes  in
               shareholders'  equity  and  cash  flows  of the  Company  and its
               Subsidiaries, for such year,

               setting  forth in each case in  comparative  form the figures for
               the previous fiscal year, all in reasonable  detail,  prepared in
               accordance with GAAP, and accompanied

                                        4

<PAGE>


                         (A) by an  opinion  thereon  of  independent  certified
                    public accountants of recognized  national  standing,  which
                    opinion shall state that such financial  statements  present
                    fairly, in all material respects,  the financial position of
                    the  companies  being  reported  upon and their  results  of
                    operations   and  cash  flows  and  have  been  prepared  in
                    conformity  with  GAAP,  and  that the  examination  of such
                    accountants in connection with such financial statements has
                    been made in accordance  with  generally  accepted  auditing
                    standards,  and that such audit provides a reasonable  basis
                    for such opinion in the circumstances, and

                         (B) a certificate of such accountants stating that they
                    have reviewed this Agreement and stating further whether, in
                    making their audit,  they have become aware of any condition
                    or event  that then  constitutes  a  Default  or an Event of
                    Default,  and, if they are aware that any such  condition or
                    event then exists,  specifying  the nature and period of the
                    existence thereof (it being understood that such accountants
                    shall not be liable, directly or indirectly, for any failure
                    to  obtain  knowledge  of any  Default  or Event of  Default
                    unless  such  accountants  should  have  obtained  knowledge
                    thereof  in making  an audit in  accordance  with  generally
                    accepted auditing standards or did not make such an audit),

               provided that the delivery within the time period specified above
               of the Company's  Annual Report on Form 10-K for such fiscal year
               (together with the Company's  annual report to  shareholders,  if
               any,  prepared  pursuant  to Rule 14a-3 under the  Exchange  Act)
               prepared in accordance with the  requirements  therefor and filed
               with the  Securities and Exchange  Commission,  together with the
               accountant's  certificate described in clause (B) above, shall be
               deemed to satisfy the requirements of this Section 4(a)(ii);

               iii.  SEC and Other  Reports  --  promptly  upon  their  becoming
          available, one copy of (i) each financial statement, report, notice or
          proxy  statement  sent by the  Company  or any  Subsidiary  to  public
          securities  holders  generally,  and (ii)  each  regular  or  periodic
          report,  each registration  statement that shall have become effective
          (without exhibits except as expressly  requested by such holder),  and
          each prospectus and all amendments thereto filed by the Company or any
          Subsidiary  with the  Securities  and Exchange  Commission  and of all
          press  releases and  statements in the nature  thereof made  available
          generally by the Company or any  Subsidiary  to the public  concerning
          developments that are Material;

               iv. Notice of Default or Event of Default -- promptly, and in any
          event within five days after a Responsible  Officer  becoming aware of
          the  existence  of any  Default or Event of Default or that any Person
          has given any  notice or taken any  action  with  respect to a claimed
          default  under any of the  Convertible  Notes or that any  Person  has
          given any notice or taken may action with respect to a claimed default
          of the type referred to in Section

                                       5

<PAGE>


         4(a)(7) of the  Convertible  Notes,  a written  notice  specifying  the
         nature and period of  existence  thereof and what action the Company is
         taking or proposes to take with respect thereto;

               v. ERISA  Matters -- promptly,  and in any event within five days
          after a Responsible Officer becoming aware of any of the following,  a
          written  notice  setting forth the nature  thereof and the action,  if
          any,  that the  Company or an ERISA  Affiliate  proposes  to take with
          respect thereto:

                    (1) with  respect  to any Plan,  any  reportable  event,  as
               defined  in  section   4043(c)  of  ERISA  and  the   regulations
               thereunder, for which notice thereof has not been waived pursuant
               to such regulations as in effect on the date hereof; or

                    (2) the  taking  by the PBGC of steps to  institute,  or the
               threatening by the PBGC of the institution of,  proceedings under
               section 4042 of ERISA for the  termination of, or the appointment
               of a trustee  to  administer,  any Plan,  or the  receipt  by the
               Company or any ERISA  Affiliate of a notice from a  Multiemployer
               Plan that such action has been taken by the PBGC with  respect to
               such Multiemployer Plan; or

                    (3) any event, transaction or condition that could result in
               the  incurrence  of any  liability  by the  Company  or any ERISA
               Affiliate  pursuant  to Title I or IV of ERISA or the  penalty or
               excise tax  provisions of the Code  relating to employee  benefit
               plans,  or in the  imposition  of any Lien on any of the  rights,
               properties  or  assets  of the  Company  or any  ERISA  Affiliate
               pursuant to Title I or IV of ERISA or such  penalty or excise tax
               provisions,  if such  liability or Lien,  taken together with any
               other such  liabilities or Liens then existing,  could reasonably
               be expected to have a Material Adverse Effect;

               vi. Notices from Governmental  Authority -- promptly,  and in any
          event within thirty days of receipt  thereof,  copies of any notice to
          the Company or any Subsidiary  from any Federal or state  Governmental
          Authority  relating  to any  order,  ruling,  statute  or other law or
          regulation  that  could  reasonably  be  expected  to have a  Material
          Adverse Effect; and

               vii. Requested  Information -- with reasonable  promptness,  such
          other  data and  information  relating  to the  business,  operations,
          affairs,  financial condition,  assets or properties of the Company or
          any of its  Subsidiaries  or relating to the ability of the Company to
          perform its obligations  hereunder and under the Convertible  Notes as
          from time to time may be  reasonably  requested  by any such holder of
          Convertible Notes.

          (b) The Company  shall  permit the  representatives  of each holder of
Convertible Notes:

                                        6

<PAGE>


               i. No Default -- if no Default or Event of Default  then  exists,
          at the expense of such holder and upon reasonable  prior notice to the
          Company,  to visit the principal  executive office of the Company,  to
          discuss  the  affairs,  finances  and  accounts of the Company and its
          Subsidiaries with the Company's officers, and (with the consent of the
          Company,   which  consent  will  not  be  unreasonably  withheld)  its
          independent public accountants,  and (with the consent of the Company,
          which  consent will not be  unreasonably  withheld) to visit the other
          offices and properties of the Company and each Subsidiary, all at such
          reasonable  times  and as  often  as may be  reasonably  requested  in
          writing; and

               ii.  Default -- if a Default or Event of Default then exists,  at
          the  expense of the Company to visit and inspect any of the offices or
          properties  of the  Company or any  Subsidiary,  to examine  all their
          respective  books of account,  records,  reports and other papers,  to
          make copies and extracts  therefrom,  and to discuss their  respective
          affairs,  finances and  accounts  with their  respective  officers and
          independent  public  accountants  (and by this  provision  the Company
          authorizes  said  accountants  to discuss the  affairs,  finances  and
          accounts of the Company and its  Subsidiaries),  all at such times and
          as often as may be requested.

          (c) The Company will and will cause each of its Subsidiaries to comply
with all laws,  ordinances or governmental rules or regulations to which each of
them is subject,  including,  without  limitation,  Environmental Laws, and will
obtain and maintain in effect all licenses,  certificates,  permits,  franchises
and  other  governmental  authorizations  necessary  to the  ownership  of their
respective properties or to the conduct of their respective businesses,  in each
case to the  extent  necessary  to ensure  that  non-compliance  with such laws,
ordinances  or  governmental  rules or  regulations  or  failures  to  obtain or
maintain in effect such licenses,  certificates,  permits,  franchises and other
governmental  authorizations  could  not,  individually  or  in  the  aggregate,
reasonably be expected to have a Material Adverse Effect.

          (d) The  Company  will  and will  cause  each of its  Subsidiaries  to
maintain, with financially sound and reputable insurers,  insurance with respect
to their  respective  properties  and  businesses  against such  casualties  and
contingencies,  of such  types,  on such  terms and in such  amounts  (including
deductibles,   co-insurance  and   self-insurance,   if  adequate  reserves  are
maintained  with  respect  thereto) as is  customary  in the case of entities of
established  reputations engaged in the same or a similar business and similarly
situated.

          (e) The  Company  will  and will  cause  each of its  Subsidiaries  to
maintain  and  keep,  or cause  to be  maintained  and  kept,  their  respective
properties in good repair, working order and condition (other than ordinary wear
and tear),  so that the  business  carried  on in  connection  therewith  may be
properly  conducted at all times,  provided  that this Section shall not prevent
the  Company  or  any  Subsidiary  from  discontinuing  the  operation  and  the
maintenance of any of its properties if such  discontinuance is desirable in the
conduct of its business and the Company has concluded  that such  discontinuance
could not,  individually  or in the aggregate,  reasonably be expected to have a
Material Adverse Effect.

                                        7

<PAGE>


          (f) The Company will and will cause each of its  Subsidiaries  to file
all  tax  returns  required  to be  filed  in any  jurisdiction  and to pay  and
discharge  all taxes shown to be due and  payable on such  returns and all other
taxes,  assessments,  governmental  charges, or levies imposed on them or any of
their  properties,  assets,  income or franchises,  to the extent such taxes and
assessments  have become due and payable and before they have become  delinquent
and all  claims for which sums have  become due and  payable  that have or might
become a Lien on properties or assets of the Company or any Subsidiary, provided
that neither the Company nor any Subsidiary  need pay any such tax or assessment
or claims if (i) the amount,  applicability  or validity thereof is contested by
the  Company  or  such  Subsidiary  on a  timely  basis  in  good  faith  and in
appropriate  proceedings,  and  the  Company  or a  Subsidiary  has  established
adequate  reserves  therefor in accordance with GAAP on the books of the Company
or such  Subsidiary or (ii) the nonpayment of all such taxes and  assessments in
the  aggregate  could not  reasonably  be  expected  to have a Material  Adverse
Effect.

          (g) The Company will at all times  preserve and keep in full force and
effect its corporate existence.  The Company will at all times preserve and keep
in full force and effect the  corporate  existence  of each of its  Subsidiaries
(unless  merged into the Company or a Subsidiary)  and all rights and franchises
of the Company and its  Subsidiaries  unless,  in the good faith judgment of the
Company,  the  termination  of or failure to preserve and keep in full force and
effect such corporate existence,  right or franchise could not,  individually or
in the aggregate, have a Material Adverse Effect.

          (h) The  Company  will  promptly  notify the  holders in the event the
Company discovers or determines that any computer  application  (including those
of its suppliers,  vendors and customers)  that is Material to its or any of its
Subsidiaries' business and operations will not be Year 2000 compliant, except to
the extent that such failure could not reasonably be expected to have a Material
Adverse Effect.

          (i) The Company will not and will not permit any  Subsidiary  to enter
into  directly  or  indirectly  any  transaction  or  Material  group of related
transactions (including without limitation the purchase, lease, sale or exchange
of  properties  of any kind or the  rendering of any service) with any Affiliate
(other than the Company or another  Subsidiary),  except in the ordinary  course
and  pursuant  to  the  reasonable   requirements   of  the  Company's  or  such
Subsidiary's  business  and upon  terms  determined  by the  Company's  Board of
Directors,  in its good faith judgment,  to be fair and reasonable  terms and no
less favorable to the Company or such  Subsidiary  than would be obtainable in a
comparable transaction with a Person not an Affiliate.

     5. CONDITIONS. The obligations of the Purchasers under this Agreement shall
be subject to the condition  that all  representations  and warranties and other
statements  of the Company  herein are true and correct at and as of the closing
of the  purchase  and sale of the  Convertible  Notes,  the  condition  that the
Company shall have performed all of its obligations  hereunder theretofore to be
performed, and the following additional conditions:

                                        8

<PAGE>


          (a) Counsel for the Company  specified  in Annex III hereto shall have
furnished to you its written  opinion,  dated the date of such closing,  in form
and substance  satisfactory to each Purchaser,  to the effect set forth in Annex
III hereto.

          (b) On the date of such closing,  the Company shall have  furnished to
each Purchaser such appropriate further information,  certificates and documents
as such Purchaser may reasonably request.

          (c)  The  representations  and  warranties  of  the  Company  in  this
Agreement shall be correct when made and at the time of the Closing.

          (d) The Company shall have  performed and complied with all agreements
and conditions  contained in this Agreement required to be performed or complied
with by it prior to or at the Closing and after  giving  effect to the issue and
sale of the  Convertible  Notes,  no  Default  or Event of  Default  shall  have
occurred and be continuing.

          (e) The Company  shall have  delivered to each  Purchaser an Officer's
Certificate,  dated  the date of the  Closing,  certifying  that the  conditions
specified in Sections 5(c), 5(d) and 5(k) have been fulfilled.

          (f) The Company shall have  delivered to each  Purchaser a certificate
certifying  as  to  the  resolutions   attached   thereto  and  other  corporate
proceedings  relating  to  the  authorization,  execution  and  delivery  of the
Convertible Notes and the Agreements.

          (g) On the date of the Closing the  purchase of  Convertible  Notes by
each  Purchaser  shall  (i) be  permitted  by the laws and  regulations  of each
jurisdiction to which such Purchaser is subject,  without recourse to provisions
(such as Section  1405(a)(8) of the New York Insurance Law)  permitting  limited
investments by insurance  companies  without  restriction as to the character of
the  particular  investment,  (ii) not violate any  applicable law or regulation
(including,  without limitation,  Regulation U, T or X of the Board of Governors
of the Federal  Reserve System) and (iii) not subject such Purchaser to any tax,
penalty or  liability  under or pursuant to any  applicable  law or  regulation,
which law or  regulation  was not in effect on the date hereof.  If requested by
any  Purchaser,  such  Purchaser  shall have  received an Officer's  Certificate
certifying as to such matters of fact as such Purchaser may  reasonably  specify
to enable such Purchaser to determine whether such purchase is so permitted.

          (h)  The  Company  shall  sell  the  entire  principal  amount  of the
Convertible Notes scheduled to be sold at the Closing as specified in Schedule I
hereto.

          (i) Without limiting the provisions of Section 6(f), the Company shall
have paid on or before the Closing the fees,  charges and  disbursements  of the
Purchasers' special counsel.

                                        9

<PAGE>


          (j) A Private  Placement  number  issued by  Standard  & Poor's  CUSIP
Service  Bureau (in  cooperation  with the  Securities  Valuation  Office of the
National  Association of Insurance  Commissioners)  shall have been obtained for
the Convertible Notes.

          (k)  The  Company   shall  not  have  changed  its   jurisdiction   of
incorporation or been a party to any merger or consolidation  and shall not have
succeeded to all or any substantial part of the liabilities of any other entity,
at any time following the date of the most recent financial  statements referred
to in the Memorandum (defined below).

          (1) All  corporate  and  other  proceedings  in  connection  with  the
transactions  contemplated  by this Agreement and all documents and  instruments
incident to such  transactions  shall be  satisfactory to each Purchaser and its
special counsel,  and each Purchaser and its special counsel shall have received
all such counterpart originals or certified or other copies of such documents as
such Purchaser or it may reasonably request.

     6.   MISCELLANEOUS.

          (a) This  Agreement  shall be binding  upon,  and inure  solely to the
benefit of, the  Purchasers  and the Company and the  respective  successors and
assigns  thereof,  and no other person shall acquire or have any right raider or
by virtue of this  Agreement.  No  purchaser  of the  Convertible  Notes  from a
Purchaser  shall be  deemed a  successor  or  assign  by  reason  merely of such
purchase.

          (b) Any notice or other  communication  required  or  permitted  to be
given hereunder  shall be deemed  effectively  given when personally  delivered,
telexed,  transmitted by facsimile or mailed by pre-paid  certified mail, return
receipt  requested,  or by  telephone  when  confirmed  in writing by one of the
preceding methods addressed as follows (as applicable):

                     If to the Company, to:

                     Celgene Corporation
                     7 Powder Horn Drive
                     Warren, NJ 07059

                     Attention: John W. Jackson
                     Telephone Number: (732) 271-1001
                     Facsimile Transmission Number: (732) 805-3931

                     with a copy to:

                     Proskauer Rose LLP
                     1585 Broadway
                     New York, NY 10036

                                       10

<PAGE>


                     Attention: Robert A. Cantone, Esq.
                     Telephone Number: (212) 969-3000
                     Facsimile Transmission Number: (212) 969-2900

                     If to Purchaser:
                     at the address and to the Person appearing on Schedule I to
                     this Agreement

                     with a copy to:

                     Choate, Hall & Stewart
                     Exchange Place
                     53 State Street
                     Boston, MA 02109

                     Attention: Frank B. Porter, Jr.
                     Telephone Number: (617) 248-5000
                     Facsimile Transmission Number: (617) 248-4000

or to such other  address or number and to the attention of such other person as
either party may designate by written notice to the other party. Notice shall be
effective upon actual receipt.

          (c) THIS  AGREEMENT  SHALL BE GOVERNED BY AND  CONSTRUED IN ACCORDANCE
WITH THE LAWS OF THE STATE OF NEW YORK.

          (d) Time shall be of the essence in the performance of this Agreement.

          (e) This Agreement may be executed by the parties hereto in any number
of counterparts,  each of which shall be deemed to be an original,  but all such
respective counterparts shall together constitute one and the same instrument.

          (f)  Whether  or  not  the   transactions   contemplated   hereby  are
consummated,  the Company will pay all costs and expenses (including  reasonable
attorneys' fees of a special counsel)  incurred by each Purchaser or holder of a
Convertible Note in connection with such transactions and in connection with any
amendments,  waivers or consents  under or in respect of this  Agreement  or the
Convertible  Notes  (whether or not such  amendment,  waiver or consent  becomes
effective),  including,  without limitation: (a) the costs and expenses incurred
in enforcing or defending (or  determining  whether or how to enforce or defend)
any rights under this Agreement or the Convertible Notes or in responding to any
subpoena  or other  legal  process or informal  investigative  demand  issued in
connection with this Agreement or the Convertible Notes, or by reason of being a
holder  of any  Convertible  Note,  and (b) the costs  and  expenses,  including
financial  advisors'  fees,  incurred  in  connection  with  the  insolvency  or
bankruptcy of the Company or any  Subsidiary or in connection  with any work-out
or restructuring of the

                                       11

<PAGE>


transactions  contemplated hereby and by the Convertible Notes. The Company will
pay, and will save each  Purchaser and each other holder of a  Convertible  Note
harmless from,  all claims in respect of any fees,  costs or expenses if any, of
brokers and finders (other than those retained by you).

          (g)  Anything  in  this  Agreement  or the  Convertible  Notes  to the
contrary  notwithstanding,  any payment of principal of or Make-Whole  Amount or
interest on any Convertible Note that is due on a date other than a Business Day
shall  be made  on the  next  succeeding  Business  Day  without  including  the
additional days elapsed in the computation of the interest  payable on such next
succeeding Business Day.

          (h) This Agreement and the Convertible  Notes may be amended,  and the
observance of any term hereof or of the Convertible  Notes may be waived (either
retroactively or prospectively), with (and only with) the written consent of the
Company and each of the holders.

          (i) From time to time hereafter, the Company will execute and deliver,
or  will  cause  to be  executed  and  delivered,  such  additional  agreements,
documents and  instruments and will take all such other actions as any holder or
holders of the Convertible Notes may reasonably request


                                  [END OF PAGE]



                                       12

<PAGE>


                    Signature Page of Note Purchase Agreement

for the purpose of implementing or effectuating the provisions contained herein,
in the Convertible Notes or in the Registration Rights Agreement.

                                                     Very truly yours,

                                                     CELGENE CORPORATION

                                                     By:/s/ Sol J. Barer
                                                        ------------------------
                                                        Name: Sol J. Barer
                                                        Title: Pres/COO


<PAGE>


       Signature Page of Note Purchase Agreement with Celgene Corporation

Accepted as of the date hereof:

JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------

JOHN HANCOCK VARIABLE LIFE INSURANCE COMPANY

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------

SIGNATURE lA (CAYMAN), LTD.
By: John Hancock Mutual Life Insurance
         Company, Portfolio Advisor

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------

Signature 3 Limited
By: John Hancock Mutual Life Insurance Company,
         as Portfolio Advisor

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------

Hancock Mezzanine Partners L.P.
By: Hancock Mezzanine Investments LLC, its General Partner
By: John Hancock Mutual Life Insurance Company.
                           as Investment Manager

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------


<PAGE>


                                                                       EXHIBIT A

     THIS SECURITY AND THE COMMON STOCK  ISSUABLE UPON ITS  CONVERSION  HAVE NOT
BEEN  REGISTERED  UNDER  THE  U.S.  SECURITIES  ACT OF  1933,  AS  AMENDED  (THE
"SECURITIES  ACT"),  AND  MAY  NOT  BE  OFFERED,   SOLD,  PLEDGED  OR  OTHERWISE
TRANSFERRED  EXCEPT PURSUANT TO AN AVAILABLE  EXEMPTION FROM REGISTRATION  UNDER
THE SECURITIES ACT AND IN ACCORDANCE WITH ALL APPLICABLE  SECURITIES LAWS OF THE
STATES OF THE UNITED STATES AND OTHER JURISDICTIONS.

                               CELGENE CORPORATION

                9.00% SENIOR CONVERTIBLE NOTE DUE JANUARY , 2004

_______                                                                  $______
No. R-

     CELGENE  CORPORATION,  a corporation  duly organized and existing under the
laws of Delaware (the "Company") for value  received,  hereby promises to pay to
__________________,    or   registered    assigns,    the   principal   sum   of
___________________________________________   Dollars  ($__________________)  on
January _____, 2004 and to pay interest thereon, from __________________,  1999,
or from the most recent interest payment date to which interest has been paid or
duly  provided  for,  semi-annually  on  January  __ and  July __ in each  year,
commencing  July __, 1999,  at the rate of 9.00% per annum,  until the principal
hereof is due, and at the rate of 11.00% per annum on any overdue  principal and
premium,  if any, and, to the extent permitted by law, on any overdue  interest.
The  interest so  payable,  and  punctually  paid or duly  provided  for, on any
interest payment date will be paid to the person in whose name this Security (or
one or more  predecessor  Securities)  is registered at the close of business on
the regular record date for such interest,  which shall be the January 1 or July
1 (whether  or not a Business  Day),  as the case may be,  next  preceding  such
interest  payment date.  Payment of the  principal of (and premium,  if any, on)
this Security  shall be made upon the surrender of this Security to the Company,
at its office at 7 Powder Horn  Drive,  Warren,  NJ 07059 (or such other  office
within  the  United  States as shall be  notified  by the  Company to the holder
hereof) (the "Designated Office"), in such coin or currency of the United States
of America as at the time of payment  shall be legal  tender for the  payment of
public and private debts, by transfer to a U.S. dollar account maintained by the
payee with a bank in the United  States of America.  Payment of interest on this
Security shall be made by wire transfer to a U.S.  dollar account  maintained by
the payee  with a bank in the United  States of  America,  provided  that if the
holder shall not have furnished wire  instructions  in writing to the Company no
later than the record date relating to an interest  payment  date,  such payment
may be made by U.S.  dollar check  mailed to the address of the Person  entitled
thereto as such address  shall  appear in the Company  security  register.  This
Security  will rank pari passu with all existing  and future  senior debt of the
Company.


<PAGE>


     This Security is one of the Company's  9.00% Senior  Convertible  Notes due
January 20, 2004, limited to $15,000,000.00  aggregate principal amount,  issued
pursuant to that certain Note  Purchase  Agreement  dated January 20, 1999 (such
agreements,  as amended,  modified and supplemented from time to time, the "Note
Purchase  Agreement") between the Company and the Purchasers named therein,  and
the holder  hereof is entitled to the benefits of the Note  Purchase  Agreement,
and may enforce the  agreements  contained  herein and therein and  exercise the
remedies  provided  for hereby and  thereby or  otherwise  available  in respect
hereof and thereof, all in accordance with the terms hereof and thereof.

          1.  Optional  Redemption  With  Premium.  This  Security is subject to
redemption  upon not less than 30 nor more than 60 days' notice by mail,  at any
time on or after January 20, 2001, as a whole or in part, (in any amount that is
an integral  multiple of $1000) at the election of the Company,  at a redemption
price of 103% the principal  amount thereof,  together with accrued  interest to
the redemption  date, but interest  installments  whose stated maturity is on or
prior to such redemption date will be payable to the holder of this Security, or
one or more  predecessor  Securities,  of record at the close of business on the
relevant record dates referred to on the face hereof;  provided,  however,  that
the Company may not redeem this  Security on or prior to January 20, 2002 unless
the Closing Price of the Common Stock exceeds 225 % of the Conversion  Price for
each  Trading Day in a period of 20  Consecutive  Trading  Days  commencing  not
earlier  than  January 20, 2001.  The term  "Conversion  Price" on any day shall
equal $1,000 divided by the Conversion Rate in effect on each such day.

          2. Conversion. (a) The holder of this Security is entitled at any time
on or after  January  20,  2000 and before the close of  business on January 20,
2004 (or, in case this Security or a portion  hereof is called for redemption or
the holder  hereof has  exercised its right to require the Company to repurchase
this  Security  or a portion  hereof,  then in respect of this  Security or such
portion hereof, as the case may be, until and including, but (unless the Company
defaults in making the payment due upon  redemption or  repurchase,  as the case
may  be)  not  after,  the  close  of  business  on the  redemption  date or the
Repurchase Date, as the case may be) to convert this Security (or any portion of
the principal amount hereof that is an integral multiple of $1,000),  into fully
paid and nonassessable  shares  (calculated as to each conversion to the nearest
1/100 of a share) of Common  Stock of the Company at the rate of 55.56 shares of
Common  Stock for each $1,000  principal  amount of Security  (or at the current
adjusted rate if an adjustment has been made as provided below) (the "Conversion
Rate") by surrender of this  Security,  duly endorsed or assigned to the Company
or in blank to the  Company at the  Designated  Office,  accompanied  by written
notice to the Company that the holder hereof elects to convert this Security (or
if less than the entire principal  amount hereof is to be converted,  specifying
the  portion  hereof to be  converted).  Upon  surrender  of this  Security  for
conversion,  the holder will be entitled to receive the interest accruing on the
principal amount of this Security then being converted from the interest payment
date next preceding the date of such  conversion to such date of conversion.  No
payment or adjustment is to be made on conversion for dividends on the

                                        2

<PAGE>


Common  Stock  issued on  conversion  hereof.  No  fractions  of shares or scrip
representing  fractions of shares will be issued on  conversion,  but instead of
any fractional  interest,  the Company shall pay a cash adjustment,  computed on
the basis of the Closing  Price of the Common  Stock on the date of  conversion,
or, at its option,  the Company  shall round up to the next higher  whole share.
This Security  shall be deemed to have been converted  immediately  prior to the
close of business on the day of surrender  hereof for conversion,  in accordance
with the foregoing provisions, and at such time the rights of the holder hereof,
as a holder hereof,  shall cease,  and the Person or Persons entitled to receive
the Common Stock  issuable on conversion  shall be treated by all Persons as the
holder or holders of such Common Stock at such time. Upon any partial conversion
of this Security,  the Company, at its expense, will forthwith issue and deliver
to,  or  upon  the  order  of the  holder  hereof,  a new  Convertible  Note  or
Convertible Notes in principal amount equal to the unconverted  principal amount
of such surrendered  Convertible  Note, such new Convertible Note or Convertible
Notes to be dated and to bear interest from the date to which  interest has been
paid on such surrendered Convertible Note.

          As promptly as possible  after the  conversion  of this  Security,  in
whole or in part, and in any event within ten (10) days thereafter, the Company,
at its expense,  will issue and deliver a certificate  or  certificates  for the
number of full shares of Common Stock issuable upon such conversion.

          (b) The Conversion  Rate shall be subject to adjustments  from time to
time as follows:

          (1) In  case  the  Company  shall  pay or  make a  dividend  or  other
     distribution on any class of capital stock of the Company payable in shares
     of Common Stock,  the Conversion  Rate in effect at the opening of business
     on the day  following  the  Determination  Date for such  dividend or other
     distribution  shall be  increased  by dividing  such  Conversion  Rate by a
     fraction  of which the  numerator  shall be the  number of shares of Common
     Stock outstanding at the close of business on such  Determination  Date and
     the  denominator  shall be the sum of such  number of shares  and the total
     number of shares  constituting  such dividend or other  distribution,  such
     increase to become effective  immediately  after the opening of business on
     the  day  following  such  Determination  Date.  For the  purposes  of this
     paragraph (1), the number of shares of Common Stock at any time outstanding
     shall not  include  shares  held in the  treasury  of the Company but shall
     include shares issuable in respect of scrip certificates  issued in lieu of
     fractions of shares of Common Stock.  The Company will not pay any dividend
     or make any  distribution on shares of Common Stock held in the treasury of
     the Company.

          (2) Subject to the last  sentence  of  paragraph  (7) of this  Section
     2(b),  in case  the  Company  shall  issue  rights,  options,  warrants  or
     convertible  securities  entitling the holders  thereof to subscribe for or
     purchase shares of Common Stock at a

                                        3

<PAGE>


     price per share less than the current market price per share (determined as
     provided in paragraph  (8) of this Section 2(b)) of the Common Stock on the
     Determination Date for such distribution,  the Conversion Rate in effect at
     the opening of business on the day following such Determination Date, shall
     be increased by dividing  such  Conversion  Rate by a fraction of which the
     numerator shall be the number of shares of Common Stock  outstanding at the
     close of business on such  Determination  Date plus the number of shares of
     Common Stock which the  aggregate  amount  received by the Company upon the
     issuance of such rights,  options,  warrants or convertible securities plus
     the  aggregate  amount  receivable  by the  Company  upon the  exercise  or
     conversion  of such rights,  options,  warrants or  convertible  securities
     would  purchase at such current market price and the  denominator  shall be
     the number of shares of Common Stock  outstanding  at the close of business
     on such  Determination  Date plus the  number of shares of Common  Stock so
     offered for  subscription  or purchase,  such increase to become  effective
     immediately  after  the  opening  of  business  on the day  following  such
     Determination Date provided, that no such adjustment need to be made in the
     case of the  granting  by the  Company to  employees  or  directors  of the
     Company or  consultants  to the Company of Common Stock  and/or  options to
     purchase Common Stock and the issuance of Common Stock upon the exercise of
     such options.  For the purposes of this paragraph (2), the number of shares
     of Common Stock at any time  outstanding  shall not include  shares held in
     the treasury of the Company but shall include shares issuable in respect of
     scrip  certificates  issued in lieu of fractions of shares of Common Stock.
     The Company  will not issue any rights,  options,  warrants or  convertible
     securities in respect of shares of Common Stock held in the treasury of the
     Company.

          (3)  In  case  outstanding  shares  of  Common  Stock  shall  each  be
     subdivided into a greater number of shares of Common Stock,  the Conversion
     Rate in effect at the opening of business on the day following the day upon
     which  such  subdivision   becomes   effective  shall  be   proportionately
     increased,  and,  conversely,  in case  outstanding  shares of Common Stock
     shall each be combined into a smaller number of shares of Common Stock, the
     Conversion  Rate in effect at the opening of business on the day  following
     the  day  upon  which  such   combination   becomes   effective   shall  be
     proportionately reduced, such increase or reduction, as the case may be, to
     become  effective  immediately  after the  opening of  business  on the day
     following  the day upon  which  such  subdivision  or  combination  becomes
     effective.

          (4) Subject to the last  sentence  of  paragraph  (7) of this  Section
     2(b),  in case the Company  shall,  by dividend  or  otherwise,  distribute
     evidences of its  indebtedness,  shares of any class of capital  stock,  or
     other  property  (including  securities,  but  excluding  (i)  any  rights,
     options,  warrants or convertible  security referred to in paragraph (2) of
     this Section 2(b) (ii) any dividend or  distribution  paid  exclusively  in
     cash,  (iii) any dividend or  distribution  referred to in paragraph (1) of
     this Section  2(b) and (iv) any merger or  consolidation  to which  Section
     2(h) applies),

                                        4

<PAGE>


     the Conversion Rate shall be adjusted so that the same shall equal the rate
     determined by dividing the Conversion Rate in effect  immediately  prior to
     the close of business on the Determination  Date for such distribution by a
     fraction of which the numerator shall be the current market price per share
     (determined  as  provided in  paragraph  (8) of this  Section  2(b)) of the
     Common Stock on such Determination Date less the then fair market value (as
     determined  in good faith by the Board of  Directors of the Company) of the
     portion of the assets,  shares or evidences of  indebtedness so distributed
     applicable to one share of Common Stock and the  denominator  shall be such
     current  market price per share of the Common  Stock,  such  adjustment  to
     become  effective  immediately  prior to the opening of business on the day
     following such Determination Date provided, that no such adjustment need be
     made in the case of an  underwritten  public  offering  of Common  Stock in
     which  the  shares of  Common  Stock are sold to the  public at a price per
     share  equal to or in excess of 95 % of the  market  price per share of the
     Common  Stock as of the date of the  pricing  of such  underwritten  public
     offering. If the Board of Directors determines the fair market value of any
     distribution  for purposes of this paragraph (4) by reference to the actual
     or  when  issued  trading  market  for  any  securities   comprising   such
     distribution,  it must in doing so consider  the prices in such market over
     the same  period  used in  computing  the  current  market  price per share
     pursuant to paragraph (8) of this Section 2(b).

          (5) In case the Company shall,  by dividend or otherwise,  make a Cash
     Distribution,  then, and in each such case,  immediately after the close of
     business  on  the  Determination  Date  for  such  Cash  Distribution,  the
     Conversion  Rate shall be  adjusted  so that the same shall  equal the rate
     determined by dividing the Conversion Rate in effect  immediately  prior to
     the close of  business  on such  Determination  Date by a fraction  (a) the
     numerator  of which  shall be equal to the current  market  price per share
     (determined  as  provided in  paragraph  (8) of this  Section  2(b)) of the
     Common  Stock  on such  Determination  Date  less an  amount  equal  to the
     quotient  of (1) the  amount of such Cash  Distribution  divided by (2) the
     number of shares of Common Stock outstanding on such Determination Date and
     (b) the denominator of which shall be equal to the current market price per
     share (determined as provided in paragraph (8) of this Section 2(b)) of the
     Common Stock on such Determination Date.

          (6) In case  the  Company  or any  Subsidiary  shall  make  an  Excess
     Purchase  Payment,  then, and in each such case,  immediately  prior to the
     opening of business  on the day after the tender  offer in respect of which
     such Excess  Purchase  Payment is to be made expires,  the Conversion  Rate
     shall be  adjusted  so that the same  shall  equal the rate  determined  by
     dividing the Conversion  Rate in effect  immediately  prior to the close of
     business on the Determination  Date for such tender offer by a fraction (a)
     the numerator of which shall be equal to the current market price per share
     (determined  as  provided in  paragraph  (8) of this  Section  2(b)) of the
     Common  Stock  on such  Determination  Date  less an  amount  equal  to the
     quotient of (A) the Excess Purchase

                                       5

<PAGE>


     Payment  divided  by (B) the number of shares of Common  Stock  outstanding
     (including  any  tendered  shares)  as of the  Determination  Date less the
     number  of  all  shares  validly  tendered  and  not  withdrawn  as of  the
     Determination  Date and (b) the  denominator of which shall be equal to the
     current market price per share  (determined as provided in paragraph (8) of
     this Section 2(b)) of the Common Stock as of such Determination Date.

          (7) The  reclassification  of Common Stock into securities  other than
     Common  Stock  (other than any  reclassification  upon a  consolidation  or
     merger to which  Section  2(h)  applies)  shall be deemed to involve  (a) a
     distribution of such  securities  other than Common Stock to all holders of
     Common  Stock (and the  effective  date of such  reclassification  shall be
     deemed to be the Determination Date), and (b) a subdivision or combination,
     as the case may be, of the  number of  shares of Common  Stock  outstanding
     immediately  prior to such  reclassification  into the  number of shares of
     Common Stock outstanding  immediately thereafter (and the effective date of
     such  reclassification  shall be  deemed  to be "the day  upon  which  such
     subdivision  becomes  effective"  or "the day upon which  such  combination
     becomes  effective",  as the case may be,  and  "the  day upon  which  such
     subdivision  or  combination  becomes  effective"  within  the  meaning  of
     paragraph  (3)  of  this  Section  2(b)).  Rights,  options,   warrants  or
     convertible  securities issued by the Company entitling the holders thereof
     to subscribe for or purchase shares of Common Stock, which rights, options,
     warrants or convertible  securities  (i) are deemed to be transferred  with
     such shares of Common Stock,  (ii) are not  exercisable  and (iii) are also
     issued in  respect of future  issuances  of Common  Stock,  in each case in
     clauses (i)  through  (iii) until the  occurrence  of a specified  event or
     events  ("Trigger  Event"),  shall for purposes of this Section 2(b) not be
     deemed issued until the occurrence of the earliest Trigger Event.

          (8)  Except  as  otherwise  provided  in the  last  sentence  of  this
     subsection  (8) of Section  2(b) for the purpose of any  computation  under
     paragraphs  (2),  (4), (5) or (6) of this  Section 2(b) the current  market
     price per  share of Common  Stock on any date  shall be  calculated  by the
     Company and be deemed to be the average of the daily Closing Prices for the
     five (5)  consecutive  Trading Days selected by the Company  commencing not
     more than ten (10)  Trading  Days  before,  and ending not later than,  the
     earlier  of the day in  question  and the day  before  the "ex  date"  with
     respect to the issuance or  distribution  requiring such  computation.  For
     purposes of this paragraph,  the term "ex date",  when used with respect to
     any  issuance  or  distribution,  means the first  date on which the Common
     Stock  trades  regular way in the  applicable  securities  market or on the
     applicable  securities  exchange without the right to receive such issuance
     or distribution. The current market price with respect to any option issued
     to any  employee or director  of the Company or  consultant  to the Company
     shall be the fair market value on the date of grant determined by reference
     to the market price on the day of the grant of such option or to the market
     price at the close of business on the  Trading  Day  immediately  preceding
     such grant.

                                        6

<PAGE>


          (9) No adjustment in the Conversion Rate shall be required unless such
     adjustment  (plus any  adjustments  not  previously  made by reason of this
     paragraph  (9))  would  require an  increase  or  decrease  of at least one
     percent in such rate;  provided,  however,  that any  adjustments  which by
     reason of this  paragraph  (9) are not required to be made shall be carried
     forward  and  taken  into  account  in  any  subsequent   adjustment.   All
     calculations  under this  Section 2 shall be made to the nearest cent or to
     the nearest one-hundredth of a share, as the case may be.

          (10) The Company may make such increases in the  Conversion  Rate, for
     the  remaining  term of the  Securities or any shorter term, in addition to
     those  required by  paragraphs  (1),  (2),  (3),  (4),  (5) and (6) of this
     Section  2(b) as it considers to be advisable in order to avoid or diminish
     any income tax to any holders of shares of Common Stock  resulting from any
     dividend or distribution of stock or issuance of rights, options,  warrants
     or  convertible  securities  to purchase or subscribe for stock or from any
     event treated as such for income tax purposes.

          (c)  Whenever the  Conversion  Rate is adjusted as provided in Section
2(b), the Company shall compute the adjusted  Conversion Rate in accordance with
Section 2(b) and shall prepare a certificate (the "Conversion Rate Certificate")
signed by the Senior Financial Officer of the Company setting forth the adjusted
Conversion  Rate and  showing  in  reasonable  detail  the facts upon which such
adjustment is based,  and shall promptly  deliver such certificate to the holder
of this Security. If the holders of the Convertible Notes and the Company cannot
agree in writing as to the adjusted  Conversion  Rate in accordance with Section
2(b), the holders of the  Convertible  Notes and the Company shall determine the
adjusted Conversion Rate in accordance with the following procedure. The holders
of the  Convertible  Notes and the Company  shall each  appoint  one  registered
securities broker,  licensed with the Securities and Exchange Commission to sell
securities  to the  public,  which  broker  shall  be a senior  vice  president,
managing  director or equivalent of a major  securities  brokerage  company with
offices in New York, New York.  Each of such brokers shall have no less than ten
(10) years  experience  in such field,  shall be  unaffiliated  with,  and their
employer securities brokerage company shall be unaffiliated with, the holders of
the Convertible Notes and the Company and shall not have previously participated
in any  underwriting  of the  Company's  Common Stock in any public  offering or
provided any Material  investment  banking or corporate advisory services to the
Company.  The holders of the Convertible  Notes and the Company shall make their
appointments  promptly and, in any event,  within thirty (30) days from the date
of the  Conversion  Rate  Certificate.  The two brokers  shall meet and shall be
instructed  to render a  determination  of the adjusted  Conversion  Rate to the
holders of the  Convertible  Notes and the Company within sixty (60) days of the
date of the Conversion Rate  Certificate.  If the two brokers cannot agree, then
each broker  shall render their  independent  determination  and the two brokers
shall simultaneously  therewith provide the name of a third broker acceptable to
the two brokers meeting the criteria set forth above.  The third broker shall be
instructed  to render a  determination  of the adjusted  Conversion  Rate within
thirty (30) days of his or her

                                       7

<PAGE>


appointment.  The two closest  determinations  of the adjusted  Conversion  Rate
shall be averaged and shall constitute the adjusted  Conversion Rate. If the two
brokers cannot agree upon a third broker,  the selection of a third broker shall
be submitted to binding arbitration in New York, New York under the rules of the
American Arbitration  Association.  In the event that the difference between the
Company's calculation of the adjusted Conversion Rate and the calculation of the
adjusted  Conversion Rate determined by the foregoing process is five percent (5
%) or greater  then the costs and  expenses of the  brokers and any  arbitration
shall be paid by and be the obligation of the Company and in the event that such
difference is less than five percent (5 %) the holders of the Convertible  Notes
(as a group) shall each pay its pro rata share of 50% of such costs and expenses
and the Company shall pay 50% of such costs and expenses.

          (d) In case:

          (1) the Company shall declare a dividend or other  distribution on its
     Common  Stock  payable  (i)  otherwise  than  exclusively  in  cash or (ii)
     exclusively in cash in an amount that would require any adjustment pursuant
     to Section 2(b); or

          (2) the Company  shall  authorize  the  granting to the holders of its
     Common Stock of rights,  options,  warrants or  convertible  securities  to
     subscribe  for or purchase  any shares of capital  stock of any class or of
     any other rights; or

          (3) of any  reclassification of the Common Stock of the Company, or of
     any consolidation, merger or share exchange to which the Company is a party
     and for which approval of any  shareholders of the Company is required,  or
     of the conveyance,  sale,  transfer or lease of all or substantially all of
     the assets of the Company; or

          (4)  of the  voluntary  or  involuntary  dissolution,  liquidation  or
     winding up of the Company; or

          (5) the Company or any  Subsidiary  shall  commence a tender offer for
     all or a portion of the  Company's  outstanding  shares of Common Stock (or
     shall amend any such tender offer);

then the Company shall cause to be delivered to the holder of this Security,  at
least 20 days (or 10 days in any case  specified  in  clause  (1) or (2)  above)
prior  to the  applicable  record,  expiration  or  effective  date  hereinafter
specified,  a notice  stating  (x) the date on which a record is to be taken for
the  purpose  of such  dividend,  distribution,  rights,  options,  warrants  or
convertible  securities or, if a record is not to be taken, the date as of which
the  holders  of  Common  Stock  of  record  to be  entitled  to such  dividend,
distribution, rights, options,

                                       8

<PAGE>


warrants or convertible  securities are to be determined,  (y) the date on which
the right to make  tenders  under such tender  offer  expires or (z) the date on
which such reclassification,  consolidation, merger, share exchange, conveyance,
transfer,  sale,  lease,  dissolution,  liquidation or winding up is expected to
become effective, and the date as of which it is expected that holders of Common
Stock of record  shall be entitled to exchange  their shares of Common Stock for
securities,  cash or other  property  deliverable  upon  such  reclassification,
consolidation,  merger,  share  exchange,  conveyance,  transfer,  sale,  lease,
dissolution,  liquidation or winding up. Neither the failure to give such notice
nor any defect therein shall affect the legality or validity of the  proceedings
described in clauses (1) through (5) of this Section 2(d).

          (e) The Company  shall at all times reserve and keep  available,  free
from preemptive rights, out of its authorized but unissued Common Stock, for the
purpose of effecting the  conversion of the Security,  the full number of shares
of Common Stock then issuable upon the conversion of this Security.

          (f) Except as provided in the next sentence,  the Company will pay any
and all taxes and duties that may be payable in respect of the issue or delivery
of shares of Common Stock on conversion of this Security. The Company shall not,
however,  be  required to pay any tax or duty which may be payable in respect of
any  transfer  involved in the issue and delivery of shares of Common Stock in a
name  other  than that of the  holder  of this  Security,  and no such  issue or
delivery  shall be made  unless and until the Person  requesting  such issue has
paid to the Company the amount of any such tax or duty,  or has  established  to
the satisfaction of the Company that such tax or duty has been paid.

          (g) The Company  agrees  that all shares of Common  Stock which may be
delivered upon  conversion of the Security,  upon such delivery,  will have been
duly authorized and validly issued and will be fully paid and nonassessable (and
shall be issued out of the Company's  authorized but unissued Common Stock) and,
except as provided in the second  sentence of Section 2(f), the Company will pay
all taxes, liens and charges with respect to the issue thereof.

          (h) In case of any consolidation of the Company with any other Person,
any merger of the  Company  into  another  Person or of another  Person into the
Company  (other  than a merger  which does not  result in any  reclassification,
conversion,  exchange or cancellation  of outstanding  shares of Common Stock of
the Company) or any conveyance,  sale, transfer or lease of all or substantially
all of the  properties  and assets of the  Company,  the  Person  formed by such
consolidation  or resulting from such merger or which  acquires such  properties
and assets,  as the case may be, shall execute and deliver to the holder of this
Security a  supplemental  agreement  providing  that such  holder has the right,
during the period this  Security  shall be  convertible  as specified in Section
2(a), to convert this Security only into the kind and amount of securities, cash
and other property receivable upon such consolidation, merger, conveyance, sale,
transfer or lease (including any Common Stock

                                        9

<PAGE>


retainable)  by a holder of the number of shares of Common  Stock of the Company
into which this Security  might have been  converted  immediately  prior to such
consolidation, merger, conveyance, sale, transfer or lease, assuming such holder
of Common  Stock of the  Company  (i) is not a Person  with  which  the  Company
consolidated,  into which the Company merged or which merged into the Company or
to which such conveyance,  sale,  transfer or lease was made, as the case may be
(a  "Constituent  Person"),  or an  Affiliate of a  Constituent  Person and (ii)
failed to exercise its rights of  election,  if any, as to the kind or amount of
securities, cash and other property receivable upon such consolidation,  merger,
conveyance,  sale,  transfer  or lease  (provided  that if the kind or amount of
securities, cash and other property receivable upon such consolidation,  merger,
conveyance,  sale,  transfer,  or lease is not the same for each share of Common
Stock of the  Company  held  immediately  prior to such  consolidation,  merger,
conveyance,  sale,  transfer or lease by others than a Constituent  Person or an
Affiliate  of a  Constituent  Person  and in  respect  of which  such  rights of
election  shall not have been  exercised  ("Non-electing  Share"),  then for the
purpose of this Section 2(h) the kind and amount of  securities,  cash and other
property receivable upon such consolidation,  merger, conveyance, sale, transfer
or lease by the  holders of each  Non-electing  Share  shall be deemed to be the
kind and  amount so  receivable  per share by a  plurality  of the  Non-electing
Shares).  Such supplemental  agreement shall provide for adjustments  which, for
events subsequent to the effective date of such supplemental agreement, shall be
as nearly  equivalent as may be practicable to the  adjustments  provided for in
this Section 2. The above  provisions of this Section 2(h) shall similarly apply
to successive consolidations,  mergers, conveyances, sales, transfers or leases.
In this paragraph,  "securities of the kind receivable" upon such consolidation,
merger,  conveyance,  transfer,  sale or lease by a holder of Common Stock means
securities  that,  among other things,  are registered  and freely  transferable
under  the  Securities  Act,  and  listed  and  approved  for  quotation  in all
securities  markets,  in each  case to the same  extent  as such  securities  so
receivable by a holder of Common Stock.

          (i) The Company (i) will effect all registrations with, and obtain all
approvals  by, all  governmental  authorities  that may be  necessary  under any
United States Federal or state law  (including the Securities  Act, the Exchange
Act and  state  securities  and Blue Sky laws)  for the  shares of Common  Stock
issuable upon conversion of this Security to be lawfully issued and delivered as
provided  herein,  and  thereafter  publicly  traded (if  permissible  under the
Securities Act) and qualified or listed as contemplated by clause (ii) (it being
understood  that the Company  shall not be required to register the Common Stock
issuable on conversion  hereof under the Securities  Act, except pursuant to the
Registration Rights Agreement between the Company and the initial holder of this
Security);  and (ii) will list the shares of Common Stock  required to be issued
and delivered upon conversion of Securities, prior to such issuance or delivery,
on each national securities exchange on which outstanding Common Stock is listed
or  quoted  at the time of such  delivery,  or if the  Common  Stock is not then
listed on any securities exchange,  to qualify the Common Stock for quotation on
the Nasdaq National Market or such other inter-dealer  quotation system, if any,
on which the Common Stock is then quoted.

                                       10

<PAGE>


          (j) For purposes  hereof:  (references to Sections shall mean Sections
of this Security unless otherwise specified)

          "Affiliate" of any specified Person means any other Person directly or
indirectly  controlling  or  controlled  by or under  direct or indirect  common
control  with  such  specified  Person.  For the  purposes  of this  definition,
"control",  when used with respect to any specified  Person,  means the power to
direct the  management  and  policies of such  Person,  directly or  indirectly,
whether  through the ownership of voting  securities,  by contract or otherwise;
and the terms  "controlling" and "controlled"  have meanings  correlative to the
foregoing.

          "Business Day" means any day other than a Saturday,  a Sunday or other
day which  shall be in Boston,  Massachusetts  or New York,  New York or a legal
holiday or a day on which commercial banks in Boston, Massachusetts or New York,
New York are required or authorized to be closed.

          "Cash  Distribution"  means the distribution by the Company to holders
of its  Common  Stock of cash,  other than any cash that is  distributed  upon a
merger  or  consolidation  to  which  Section  2(h)  applies  or  as  part  of a
distribution referred to in paragraph (4) of Section 2(b).

          "Change of Control" is defined in Section 3(f)(2).

          "Closing" is defined in Section 1 of the Note Purchase Agreement.

          "Closing  Price"  means,  with  respect  to the  Common  Stock  of the
Company,  for any day,  the  reported  last sale  price per share on the  Nasdaq
National  Market,  or, if the  Common  Stock is not  admitted  to trading on the
Nasdaq  National  Market,  on the  principal  national  securities  exchange  or
inter-dealer quotation system on which the Common Stock is listed or admitted to
trading,  or if not admitted to trading on the Nasdaq National Market, or listed
or  admitted to trading on any  national  securities  exchange  or  inter-dealer
quotation  system,  the average of the closing bid and asked prices per share in
the  over-the-counter  market as furnished by any New York Stock Exchange member
firm selected from time to time by the Company for that purpose.

          "Code" means the Internal  Revenue Code of 1986,  as amended from time
to time, and the rules and regulations promulgated thereunder from time to time.

          "Common  Stock" means the Common Stock,  par value $.01 per share,  of
the Company  authorized at the date of this  instrument as originally  executed.
Subject to the  provisions  of Section  2(h),  shares  issuable on conversion or
repurchase of this Security  shall include only shares of Common Stock or shares
of any class or classes of common stock resulting from any  reclassification  or
reclassifications thereof; provided, however, that if at

                                       11

<PAGE>


any time  there  shall be more  than one such  resulting  class,  the  shares so
issuable  on  conversion  of this  Security  shall  include  shares  of all such
classes,  and  the  shares  of  each  such  class  then  so  issuable  shall  be
substantially  in the proportion  which the total number of shares of such class
resulting from all such reclassifications bears to the total number of shares of
all such classes resulting from all such reclassifications.

          "Convertible  Note(s)"shall  mean one or more of the  Company's  9.00%
Senior Convertible Notes due January 20, 2004.

          "Conversion Price" is defined in Section 1.

          "Conversion Rate" is defined in Section 2(a).

          "Default"  means an event or condition the  occurrence or existence of
which would,  with the lapse of time or the giving of notice or both,  become an
Event of Default.

          "Designated Office" is defined in the Preamble.

          "Determination  Date"  means,  in the  case  of a  dividend  or  other
distribution, including the issuance of rights, options, warrants or convertible
securities, to the date fixed for the determination of those entitled to receive
such dividend or other distribution, and in the case of a tender offer, the last
time that tenders could have been made pursuant to such tender offer.

          "Environmental  Laws" means any and all  Federal,  state,  local,  and
foreign statutes,  laws,  regulations,  ordinances,  rules,  judgments,  orders,
decrees,   permits,   licenses,   written  agreements  or  written  governmental
restrictions  relating to pollution and the protection of the environment or the
release of any  materials  into the  environment,  including  but not limited to
those related to hazardous substances or wastes, air emissions and discharges to
waste or public systems.

          "ERISA" means the Employee  Retirement Income Security Act of 1974, as
amended from time to time, and the rules and regulations  promulgated thereunder
from time to time in effect.

          "ERISA  Affiliate"  means  any  trade  or  business  (whether  or  not
incorporated)  that is treated as a single  employer  together  with the Company
under section 414 of the Code.

          "Excess Purchase Payment" means the product of (A) the excess, if any,
of (i) the  amount of cash plus the fair  market  value (as  determined  in good
faith  by the  Company's  Board  of  Directors)  of any  non-cash  consideration
required to be paid with respect to one share of Common Stock  acquired or to be
acquired in a tender offer made by the Company

                                       12

<PAGE>


or any Subsidiary of the Company for all or any portion of the Common Stock over
(ii) the current  market price per share as of the last time that tenders  could
have been  made  pursuant  to such  tender  offer  and (B) the  number of shares
validly  tendered and not withdrawn as of the  Determination  Date in respect of
such tender offer.

          "Event of Default" is defined in the preamble to Section 4.

          "Exchange  Act" shall mean the  Securities  Exchange  Act of 1934,  as
amended, or any successor Federal statute,  and the rules and regulations of the
Securities and Exchange Commission promulgated thereunder, all as the same shall
be in effect from time to time.

          "GAAP" means  generally  accepted  accounting  principles as in effect
from time to time in the United States of America.

          "Hazardous Materials" means any and all pollutants, toxic or hazardous
wastes or any other substances that might pose a hazard to health or safety, the
remediation of which may be required or the generation,  manufacture,  refining,
production, processing, treatment, storage, handling, transportation,  transfer,
use, disposal, release, discharge,  spillage, seepage, or filtration of which is
restricted,   prohibited  or  penalized  by  any  applicable  Environmental  Law
(including, without limitation,  asbestos, urea formaldehyde foam insulation and
polychlorinated biphenyls).

          "holder" means, with respect to this Security or any other Convertible
Note,  the Person in whose name it is registered  in the register  maintained by
the Company pursuant to Section 6(d).

          "Lien" means, with respect to any Person, any mortgage,  lien, pledge,
charge, security interest or other encumbrance,  or any interest or title of any
vendor,  lessor,  lender or other  secured  party to or of such Person under any
conditional sale or other title retention agreement or Capital Lease (as defined
by  GAAP),  upon or  with  respect  to any  property  or  asset  of such  Person
(including in the case of stock, stockholder agreements, voting trust agreements
and all similar arrangements).

          "Make-Whole Amount" is defined in Section 4(g).

          "Material"  means  material in relation to the  business,  operations,
affairs,  financial condition,  assets,  properties, or prospects of the Company
and its Subsidiaries taken as a whole.

          "Material  Adverse Effect" means a material  adverse effect on (a) the
business,  operations,  affairs,  financial  condition,  assets,  properties  or
prospects  of the  Company  and its  Subsidiaries  taken as a whole,  or (b) the
ability of the  Company  to  perform  its  obligations  under the Note  Purchase
Agreement, the Registration Rights Agreement and the Convertible Notes, or (cc.)
the validity or enforceability of this Agreement or the Convertible Notes.

                                       13

<PAGE>


          "Multiemployer Plan" means any Plan that is a "multiemployer plan" (as
such term is defined in section 4001(a)(3) of ERISA).

          "Note Purchase Agreement" is defined in the Preamble.

          "PBGC" means the Pension Benefit Guaranty  Corporation referred to and
defined in ERISA or any successor thereto.

          "Person"  means  an  individual,  partnership,   corporation,  limited
liability  company,  association,   trust,  unincorporated  organization,  or  a
government or agency or political subdivision thereof.

          "Plan" means an "employee benefit plan" (as defined in section 3(3) of
ERISA) that is or,  within the preceding  five years,  has been  established  or
maintained,  or to which  contributions are or, within the preceding five years,
have been made or required to be made, by the Company or any ERISA  Affiliate or
with respect to which the Company or any ERISA Affiliate may have any liability.

          "Purchaser(s)"  JOHN  HANCOCK  MUTUAL  LIFE  INSURANCE  COMPANY;  JOHN
HANCOCK VARIABLE LIFE INSURANCE COMPANY; SIGNATURE 1A (CAYMAN), LTD; SIGNATURE 3
LIMITED; and HANCOCK MEZZANINE PARTNERS L.P.

          "Registration   Rights   Agreement"  means  the  Registration   Rights
Agreement dated as of the date hereof among the Purchasers and the Company.

          "Repurchase Date" is defined in Section 3(a).

          "Repurchase Price" is defined in Section 3(a).

          "Responsible  Officer" means any),  Senior  Financial  Officer and any
other senior officer of the Company with  responsibility  for the administration
of the relevant covenants in this Security or in the Note Purchase Agreement.

          "Securities Act" shall mean the Securities Act of 1933, as amended, or
any successor  Federal statute,  and the rules and regulations of the Securities
and  Exchange  Commission  promulgated  thereunder,  all as the same shall be in
effect from time to time.

          "Senior  Financial   Officer"  means  the  chief  financial   officer,
principal accounting officer, treasurer or comptroller of the Company.

          "Subsidiary" means, as to any Person, any corporation,  association or
other business entity in which such Person or one or more of its Subsidiaries or
such Person and one or

                                       14

<PAGE>


more of its Subsidiaries owns sufficient equity or voting interests to enable it
or them (as a group)  ordinarily,  in the absence of  contingencies,  to elect a
majority of the  directors  (or Persons  performing  similar  functions) of such
entity,  and any partnership or joint venture if more than a 50% interest in the
profits  or  capital  thereof  is  owned  by such  Person  or one or more of its
Subsidiaries  or such Person and one or more of its  Subsidiaries  (unless  such
partnership  can and does  ordinarily  take major business  actions  without the
prior  approval of such Person or one or more of its  Subsidiaries).  Unless the
context  otherwise  clearly  requires,  any  reference  to a  "Subsidiary"  is a
reference to a Subsidiary of the Company.

          "Trading  Day" means (i) if the Common Stock is admitted to trading on
the Nasdaq  National  Market or any other system of automated  dissemination  of
quotations of securities  prices,  a day on which trades may be effected through
such  system;  (ii) if the Common Stock is listed or admitted for trading on the
New York Stock  Exchange or any other  national  securities  exchange,  a day on
which such  exchange is open for  business;  or (iii) if the Common Stock is not
admitted  to trading on the Nasdaq  National  Market or listed or  admitted  for
trading on any  national  securities  exchange or any other  system of automated
dissemination of quotation of securities prices, a day on which the Common Stock
is traded regular way in the over-the-counter market and for which a closing bid
and a closing asked price for the Common Stock are available.

          3.  Right to  Require  Repurchase.  (a) In the event  that a Change in
Control shall occur,  then the holder of this Security shall have the right,  at
such  holder's  option,  to  require  the  Company to  repurchase,  and upon the
exercise of such right the  Company  shall  repurchase,  this  Security,  or any
portion of the  principal  amount hereof that is equal to $1,000 or any integral
multiple  thereof,  on the date (the  "Repurchase  Date")  that is  thirty  (30)
Trading  Days after the date on which the Company  gives  notice  thereof to the
holder of this  Security,  at a purchase  price  equal to 100% of the  principal
amount  of  this  Security  to be  repurchased  plus  interest  accrued  to  the
Repurchase Date (the "Repurchase Price");  provided,  however, that installments
of  interest  on this  Security  whose  stated  maturity  is on or  prior to the
Repurchase Date shall be payable to the holder of this Security,  or one or more
predecessor Securities, registered as such on the relevant Record Date according
to their terms. At the option of the Company,  the Repurchase  Price may be paid
in cash or subject to the fulfillment by the Company of the conditions set forth
in each of Section 5 and Section 6 and subject to the  limitations  set forth in
each of Section 5 and  Section 6, by  delivery  of shares of Common  Stock or in
common stock of any Person which  succeeds the Company up to a maximum amount of
ten percent  (10%) of the then  issued and  outstanding  Common  Stock or common
stock of such Person  following any Change in Control,  provided,  however,  the
cash plus the fair market value of such shares shall equal the Repurchase Price.
The Company  agrees to give the holder of this Security  notice of any Change in
Control,  by facsimile  transmission  confirmed in writing by overnight  courier
service, promptly and in any event within two (2) Trading Days of the occurrence
thereof.

                                       15

<PAGE>


          (b) To exercise a repurchase  right,  the holder shall  deliver to the
Company on or before the 10th Trading Day prior to the Repurchase Date, together
with this Security, written notice of the holder's exercise of such right, which
notice  shall set forth the name of the  holder,  the number of shares of Common
Stock then owned by such holder and its affiliates, the principal amount of this
Security to be repurchased  (and, if this Security is to be repurchased in part,
the portion of the principal  amount thereof to be  repurchased  and the name of
the  person in which  the  portion  thereof  to remain  outstanding  after  such
repurchase is to be registered) and a statement that an election to exercise the
repurchase  fight is being made  thereby  and, in the event that the  Repurchase
Price shall be paid in whole or in part by the  delivery of shares,  as provided
above,  the name or names  (and the  addresses)  in which the  certificates  for
shares shall be issued.  Such written notice shall be  irrevocable,  except that
the fight of the holder to convert  this  Security  (or the portion  hereof with
respect to which the repurchase  right is being  exercised) shall continue until
the close of business on the  Repurchase  Date (or if the Company  elects to pay
the Repurchase Price by delivery of shares as provided above, until the close of
business on the Trading Day  immediately  preceding the first delivery of shares
with respect thereto).

          (c) In the event a repurchase  right shall be exercised in  accordance
with the terms  hereof,  the Company shall pay or cause to be paid to the holder
the Repurchase Price in cash or shares, as provided above, together with accrued
and unpaid interest to the Repurchase Date; provided, however, that installments
of interest that mature on or prior to the  Repurchase  Date shall be payable in
cash, to the holders of this Security,  or one or more  predecessor  Securities,
registered as such at the close of business on the relevant regular record date.

          (d)  If  this  Security  (or  portion   thereof)  is  surrendered  for
repurchase and is not so paid on or prior to the Repurchase  Date, the principal
amount of this  Security  (or such  portion  hereof,  as the case may be) shall,
until paid,  bear interest to the extent  permitted by  applicable  law from the
Repurchase Date at eleven percent (11%) per annum, and shall remain  convertible
into Common Stock until the principal of this Security (or portion  thereof,  as
the case may be) shall have been paid or duly provided for.

          (e) If this  Security is to be  repurchased  only in part, it shall be
surrendered  to the Company at the  Designated  Office (with,  if the Company so
requires,  due  endorsement  by, or a written  instrument  of  transfer  in form
satisfactory  to the Company duly executed by, the holder hereof or his attorney
duly  authorized in writing),  and the Company shall execute and make  available
for delivery to the holder without service charge, a new Security or Securities,
containing identical terms and conditions, each in an authorized denomination in
aggregate  principal  amount  equal  to and in  exchange  for the  unrepurchased
portion of the principal of the Security so surrendered.

          (f) For purposes of this Section 3.

          (1) the term "beneficial owner" shall be determined in accordance with
Rule 13d-3 promulgated by the Securities and Exchange Commission pursuant to the
Exchange Act; and

                                       16

<PAGE>


          (2) a "Change  in  Control"  shall be deemed to have  occurred  at the
time, after the original issuance of this Security, of:

          (i) the acquisition by any Person of beneficial ownership, directly or
     indirectly,  through a purchase, merger or other acquisition transaction or
     series of transactions, of shares of capital stock of the Company entitling
     such Person to exercise 50% or more of the total voting power of all shares
     of capital stock of the Company  entitled to vote generally in the election
     of  directors  (any  shares of  voting  stock of which  such  Person is the
     beneficial owner that are not then outstanding being deemed outstanding for
     purposes of calculating such percentage) other than any such acquisition by
     the Company or any employee benefit plan of the Company; or

          (ii) any  consolidation  or merger of the  Company  with or into,  any
     other Person, any merger of another Person with or into the Company, or any
     conveyance,   transfer,   sale,  lease  or  other  disposition  of  all  or
     substantially  all of the assets of the  Company to another  Person  (other
     than  (a)  any  such   transaction   (x)  which  does  not  result  in  any
     reclassification,  conversion,  exchange  or  cancellation  of  outstanding
     shares of Common  Stock and (y)  pursuant to which  holders of Common Stock
     immediately  prior to such  transaction  have the  entitlement to exercise,
     directly or indirectly, 50% or more of the total voting power of all shares
     of capital stock entitled to vote generally in the election of directors of
     the continuing or surviving Person  immediately  after such transaction and
     (b) any  merger  which is  effected  solely to change the  jurisdiction  of
     incorporation of the Company and results in a reclassification,  conversion
     or exchange of  outstanding  shares of Common  Stock into solely  shares of
     common stock,

          4. Events of Default.  (a) "Event of Default",  wherever  used herein,
means any one of the  following  events  (whatever  the reason for such Event of
Default  and  whether it shall be  voluntary  or  involuntary  or be effected by
operation  of law or pursuant to any  judgment,  decree or order of any court or
any order, rule or regulation of any administrative or governmental body):

          (1) (A) default in the payment of any  principal  or premium,  if any,
     upon this  Security  when the same  becomes  due and  payable,  whether  at
     maturity or at a date fixed for  prepayment or by  declaration or otherwise
     or (B) default in the payment of any interest  upon this  Security  when it
     becomes due and payable,  and  continuance  of such default for a period of
     five (5) days; or

          (2) default by the Company in the  performance  of its  obligations in
     respect of any  conversion  of this  Security  (or any  portion  hereof) in
     accordance with Section 2; or

          (3)  failure by the  Company to give any notice of a Change of Control
     required to be delivered in accordance with Section 3(a); or

          (4) default in the performance, or breach, of any material covenant or
     warranty of the Company herein, in the Note Purchase  Agreement,  or in the
     Registration

                                       17

<PAGE>


     Rights  Agreements  (other  than a  covenant  or  warranty a default in the
     performance or breach of which is specifically dealt with elsewhere in this
     Section 4(a)) and  continuance of such default or breach for a period of 30
     days after the earlier to occur of (A) the Company's obtaining knowledge of
     such default or (B) the Company's  receiving written notice specifying such
     default or breach and  requiring  it to be remedied  and stating  that such
     notice is a "Notice of Default" hereunder; or

          (5) any  representation or warranty made in writing by or on behalf of
     the Company or by any officer of the Company  furnished in connection  with
     the transactions contemplated hereby proves to have been false or incorrect
     in any material respect on the date as of which made; or

          (6) a final judgment or judgments for the payment of money aggregating
     in excess of $250,000 are  rendered  against one or more of the Company and
     its  Subsidiaries  and which  judgments are not, within 60 days after entry
     thereof, bonded, discharged or stayed pending appeal, or are not discharged
     within 60 days after the expiration of such stay; or

          (7) a default  under any bond,  debenture,  note or other  evidence of
     indebtedness  for money  borrowed by the Company,  or under any  agreement,
     mortgage,  indenture  or  instrument  under which there may be issued or by
     which there may be secured or evidenced any indebtedness for money borrowed
     by the  Company,  with a  principal  amount then  outstanding  in excess of
     $1,000,000,  whether  such  indebtedness  now exists or shall  hereafter be
     created,  which default shall  constitute a failure to pay the principal of
     such  indebtedness  (in whole or in any part greater than  $1,000,000) when
     due and payable or shall have resulted in such indebtedness (in whole or in
     any part  greater  than  $1,000,000)  becoming  or being  declared  due and
     payable prior to the date on which it would  otherwise  have become due and
     payable; or

          (8) if(i) any Plan  other  than a  Multiemployer  Plan  shall  fail to
     satisfy the  minimum  funding  standards  of ERISA or the Code for any plan
     year or part  thereof or a waiver of such  standards  or  extension  of any
     amortization  period is sought or granted  under  section  412 of the Code,
     (ii) a notice of intent to  terminate  any Plan other than a  Multiemployer
     Plan shall have been or is reasonably expected to be filed with the PBGC or
     the PBGC shall have  instituted  proceedings  under ERISA  section  4042 to
     terminate  or  appoint  a  trustee  to  administer  any Plan  other  than a
     Multiemployer Plan or the PBGC shall have notified the Company or any ERISA
     Affiliate that a Plan other than a Multiemployer  Plan may become a subject
     of any such  proceedings,  (iii) the aggregate  "amount of unfunded benefit
     liabilities" (within the meaning of section 4001(a)(18) of ERISA) under all
     Plans other than a Multiemployer Plan,  determined in accordance with Title
     IV of ERISA, shall exceed $250,000, (iv) the Company or any ERISA Affiliate
     shall  have  incurred  or is  reasonably  expected  to incur any  liability
     pursuant to Title I or IV of ERISA or the penalty or excise tax  provisions
     of the Code  relating to  employee  benefit  plans,  (v) the Company or any
     ERISA Affiliate  withdraws from any Multiemployer Plan, or (vi) the Company
     or any Subsidiary  establishes or amends any employee  welfare benefit plan
     that  provides  post-employment  welfare  benefits  in a manner  that would
     increase the liability of the

                                       18

<PAGE>


     Company  or any  Subsidiary  thereunder;  and  any  such  event  or  events
     described  in clauses  (i)  through  (vi)  above,  either  individually  or
     together with any other such event or events,  could reasonably be expected
     to have a Material Adverse Effect.  (As used in this Section  4(a)(8),  the
     terms  "employee  benefit plan" and "employee  welfare  benefit plan" shall
     have  the  respective  meanings  assigned  to such  terms in  Section  3 of
     ERISA.); or

          (9)  if,  as  a  result  of  any   Change  of  Control  or  any  other
     consolidation  or merger,  the holding by the  Purchasers  or any assignees
     thereof of this Security or the holding of any Common Stock or common stock
     of any Person  succeeding  the  Company,  issued to the  Purchasers  or any
     assignees thereof after conversion of this Security would constitute,  with
     respect  to  any  Plan  (other  than a  Multiemployer  Plan)  a  prohibited
     transaction which would violate the prohibitions of section 406 of ERISA or
     which  would  subject  any  "disqualified  person"  (as  defined in section
     4975(e)(2) of the Code) to a tax pursuant to section  4975(c)(1)(A)-(D)  of
     the Code; or

          (10) the entry by a court having jurisdiction in the premises of (A) a
     decree or order for relief in respect of the Company in an involuntary case
     or proceeding under any applicable Federal or State bankruptcy, insolvency,
     reorganization  or other similar law or (B) a decree or order adjudging the
     Company a bankrupt or insolvent,  or approving as properly filed a petition
     seeking  reorganization,  arrangement,  adjustment or  composition of or in
     respect of the  Company  under any  applicable  Federal  or State  law,  or
     appointing   a  custodian,   receiver,   liquidator,   assignee,   trustee,
     sequestrator or other similar official of the Company or of any substantial
     part of its  property,  or ordering  the winding up or  liquidation  of its
     affairs,  and the continuance of any such decree or order for relief or any
     such  other  decree  or order  unstayed  and in  effect  for a period of 60
     consecutive days; or

          (11) the commencement by the Company of a voluntary case or proceeding
     under   any   applicable   Federal   or   State   bankruptcy,   insolvency,
     reorganization  or other  similar law or of any other case or proceeding to
     be  adjudicated a bankrupt or insolvent,  or the consent by it to the entry
     of a decree or order for relief in respect of the Company in an involuntary
     case or  proceeding  under  any  applicable  Federal  or State  bankruptcy,
     insolvency,  reorganization  or other similar law or to the commencement of
     any bankruptcy or insolvency  case or proceeding  against it, or the filing
     by it of a petition or answer or consent seeking  reorganization or similar
     relief under any  applicable  Federal or State law, or the consent by it to
     the filing of such petition or to the  appointment of or taking  possession
     by a custodian,  receiver,  liquidator,  assignee, trustee, sequestrator or
     other  similar  official of the Company or of any  substantial  part of its
     property,  or  the  making  by it of  an  assignment  for  the  benefit  of
     creditors,  or not paying its debts as they become due or the  admission by
     it in writing of its  inability  to pay its debts  generally as they become
     due, or the taking of corporate action by the Company in furtherance of any
     such action.

          (b) If an Event of Default  (other than an Event of Default  specified
in Section  4(a)(10) or 4(a)(11))  occurs and is continuing,  then in every such
case the holder of this Security may declare the principal  hereof to be due and
payable immediately, by a notice in

                                       19

<PAGE>


writing to the Company,  and upon any such  declaration  such  principal and all
accrued  interest  hereon  shall  become  immediately  due and  payable  without
presentment,  demand,  protest  or other  notice of any  kind,  all of which are
hereby  expressly  waived,  and  the  Company  shall  forthwith  upon  any  such
acceleration  pay to the holder of this Security 0) the entire  principal of and
interest accrued on this Security, and (ii) in addition, to the extent permitted
by  applicable  law, an amount  equal to the Make Whole  Amount,  as  liquidated
damages  and not as a penalty;  and,  in case of the  occurrence  of an Event of
Default of the  character  described  in  subdivisions  4(a)(10) or 4(a)(11) the
principal  of and accrued  interest on this  Security,  ipso facto shall  become
immediately  due and payable  without any declaration or other act of the holder
of this Security and without presentment, demand, protest or other notice of any
kind, all of which are hereby expressly waived,  and the Company shall forthwith
upon any such  acceleration  pay to the holder of this  Security  (x) the entire
principal of and interest accrued on this Security and (y) in addition,  if such
Event  of  Default  is  "Voluntary"  (as  hereinafter  defined),  to the  extent
permitted  by  applicable  law, an amount  equal to the  Make-Whole  Amount,  as
liquidated damages and not as a penalty.

     For  purposes  of this  section  4(a),  "Voluntary"  shall mean an Event of
Default of the character  described in  subdivisions  4(a)(10) or 4(a)(11) which
shall  have  been  (x-)  procured  by  the  Company  or any  officer,  director,
stockholder or Affiliate of the Company or (y) primarily the result of action or
inaction by the Company or by any officer, director, stockholder or Affiliate of
the Company.

          (c) In case any one or more of the  Events  of  Default  specified  in
section 4(a) shall have occurred,  and irrespective of whether this Security has
become or has been declared  immediately due and payable under section 4(a), the
holder of this  Security may proceed to protect and enforce its rights either by
suit in equity or by action at law,  or both.  The Company  stipulates  that the
remedies  at law of the holder of this  Security  in the event of any Default or
threatened  Default by the Company in the  performance of or compliance with any
covenant or  agreement  in this  Security,  the Note  Purchase  Agreement or the
Registration  Rights Agreement are not and will not be adequate and that, to the
fullest extent  permitted by law, such terms may be  specifically  enforced by a
decree for the specific performance thereof,  whether by an injunction against a
violation thereof or otherwise.

          (d) No remedy conferred in this Security,  the Note Purchase Agreement
or the  Registration  Rights  Agreement is intended to be exclusive of any other
remedy,  and each and every  such  remedy  shall be  cumulative  and shall be in
addition to every other remedy given hereunder or thereunder or now or hereafter
existing at law or in equity or by statute or otherwise.

          (e)  No  course  of  dealing  between  the  Company  and  any  of  its
Subsidiaries,  on the one hand,  and the holder of this  Security,  on the other
hand,  and no delay by any such holder in  exercising  any rights  hereunder  or
under the Note Purchase  Agreement or the  Registration  Rights  Agreement shall
operate as a waiver of any rights of such holder.

                                       20

<PAGE>


          (f) In case any one or more of the  Events  of  Default  specified  in
section 4(a) shall have occurred, all amounts to be applied to the prepayment or
payment of this  Security  shall be  applied,  after the  payment of all related
costs and expenses incurred by the holder of this Security  (including,  without
limitation,  compensation  to any and all  trustees,  liquidators,  receivers or
similar officials and reasonable fees, expenses and disbursements of counsel) in
such order of priority as is determined by the holder of this Security.

          (g) The term "Make-Whole Amount" means, with respect to this Security,
an amount equal to the excess,  if any, of the Discounted Value of the Remaining
Scheduled  Payments  with respect to the Called  Principal of this Security over
the amount of such Called Principal,  provided that the Make-Whole Amount may in
no event be less than zero.  For the  purposes  of  determining  the  Make-Whole
Amount, the following terms have the following meanings:

          "Called Principal" means, with respect to this Security, the principal
     of this Security that has become or is declared to be  immediately  due and
     payable pursuant to Section 4(b).

          "Discounted Value" means, with respect to the Called Principal of this
     Security,  the amount  obtained  by  discounting  all  Remaining  Scheduled
     Payments  with  respect to such  Called  Principal  from  their  respective
     scheduled  due dates to the  Settlement  Date with  respect to such  Called
     Principal, in accordance with accepted financial practice and at a discount
     factor  (applied on the same  periodic  basis as that on which  interest on
     this Security is payable) equal to the  Reinvestment  Yield with respect to
     such Called Principal.

          "Reinvestment  Yield" means,  with respect to the Called  Principal of
     this Security,  150 basis points over the yield to maturity  implied by (i)
     the yields  reported,  as of 10:00 A.M.  (New York City time) on the second
     Business  Day  preceding  the  Settlement  Date with respect to such Called
     Principal,  on the display designated as "PX-I" of the Bloomberg  Financial
     Markets Services Screen for actively traded U.S. Treasury securities having
     a maturity equal to the Remaining  Average Life of such Called Principal as
     of such Settlement Date, or (ii) if such yields are not reported as of such
     time or the  yields  reported  as of such time are not  ascertainable,  the
     Treasury Constant  Maturity Series Yields reported,  for the latest day for
     which such  yields  have been so  reported  as of the second  Business  Day
     preceding the  Settlement  Date with respect to such Called  Principal,  in
     Federal  Reserve  Statistical  Release  H.  15  (519)  (or  any  comparable
     successor  publication) for actively traded U.S. Treasury securities having
     a constant  maturity  equal to the  Remaining  Average  Life of such Called
     Principal  as  of  such  Settlement   Date.  Such  implied  yield  will  be
     determined,  if necessary,  by (a) converting U.S. Treasury bill quotations
     to  bond-equivalent  yields in accordance with accepted  financial practice
     and (b)  interpolating  linearly  between  (1)  the  actively  traded  U.S.
     Treasury  security  with  the  duration  closest  to and  greater  than the
     Remaining  Average Life and (2) the actively traded U.S.  Treasury security
     with the duration closest to and less than the Remaining Average Life.

                                       21

<PAGE>


          "Remaining  Average Life" means, with respect to any Called Principal,
     the number of years  (calculated to the nearest  one-twelfth year) obtained
     by dividing  (i) such Called  Principal  into (ii) the sum of the  products
     obtained by  multiplying  (,a.) the principal  component of each  Remaining
     Scheduled  Payment with respect to such Called  Principal by (b) the number
     of years  (calculated  to the  nearest  one-twelfth  year) that will elapse
     between the Settlement  Date with respect to such Called  Principal and the
     scheduled due date of such Remaining Scheduled Payment.

          "Remaining  Scheduled  Payment"  means,  with  respect  to the  Called
     Principal  of this  Security,  all  payments of such Called  Principal  and
     interest  thereon that would be due after the Settlement  Date with respect
     to such Called  Principal if no payment of such Called  Principal were made
     prior to its scheduled due date,  provided that if such  Settlement Date is
     not a date on which interest payments are due to be made under the terms of
     this Security,  then the amount of the next succeeding  scheduled  interest
     payment  will  be  reduced  by the  amount  of  interest  accrued  to  such
     Settlement Date.

          "Settlement  Date" means, with respect to the Called Principal of this
     Security,  the date on which  such  Called  Principal  or has  become or is
     declared to be immediately due and payable pursuant to Section 4(b).

          5.  Consolidation,  Merger, Etc. (a) The Company shall not consolidate
with or merge  into  any  other  Person  or,  directly  or  indirectly,  convey,
transfer, sell or lease all or substantially all of its properties and assets to
any Person,  and the Company shall not permit any Person to consolidate  with or
merge into the Company or,  directly or indirectly,  convey,  transfer,  sell or
lease all or  substantially  all of its  properties  and assets to the  Company,
unless:

          (1) in case the Company shall  consolidate  with or merge into another
     Person or convey,  transfer,  sell or lease all or substantially all of its
     properties   and  assets  to  any  Person,   the  Person   formed  by  such
     consolidation  or into  which the  Company  is merged or the  Person  which
     acquires  by  conveyance,  transfer  or  sale,  or  which  leases,  all  or
     substantially  all the  properties  and  assets of the  Company  shall be a
     corporation,  limited  liability  company,  partnership or trust,  shall be
     organized  and  validly  existing  under the laws of the  United  States of
     America,  any State thereof or the District of Columbia and shall expressly
     assume, by an agreement supplemental hereto,  executed and delivered to the
     holder of this  Security in form  satisfactory  to the holder,  the due and
     punctual payment of the principal of (and premium,  if any) and interest on
     this Security and the  performance  or observance of every covenant of this
     Security on the part of the Company to be performed or observed,  including
     the conversion  rights  provided herein (which shall  thereafter  relate to
     common stock of such successor,  on a basis reasonably designed to preserve
     the  economic  value to the  holder  of this  Security  of such  conversion
     rights);

          (2) immediately  after giving effect to such  transaction and treating
     any indebtedness which becomes an obligation of the Company or a Subsidiary
     of the Company as a result of such  transaction  as having been incurred by
     the  Company  or  such  Subsidiary  of the  Company  at the  time  of  such
     transaction, no Event of Default, and no

                                       22

<PAGE>


     event which,  after notice or lapse of time or both,  would become an Event
     of Default, shall have happened and be continuing;

          (3) the  Company  has  delivered  to the  holder of this  Security  an
     officers' certificate stating that such consolidation,  merger, conveyance,
     transfer,  sale or lease and, if a  supplemental  agreement  is required in
     connection with such transaction,  such supplemental agreement, comply with
     this Section and that all conditions precedent herein provided for relating
     to such transaction have been complied with; and

          (4)  counsel  for the  Company  has  delivered  to the  holder of this
     Security an opinion of such  counsel  with  respect to such  consolidation,
     merger,  conveyance,  transfer,  sale  or  lease,  and  if  a  supplemental
     agreement  is  required  in   connection   with  such   transaction,   such
     supplemental  agreement,  which  opinion  shall be, in form and  substance,
     reasonably acceptable to such holder and its counsel.

          (b) upon any  consolidation  of the  Company  with,  or  merger of the
Company into, any other Person or any conveyance, transfer, sale or lease of all
or  substantially  all of the properties and assets of the Company in accordance
with Section 5(a),  the successor  Person formed by such  consolidation  or into
which the Company is merged or to which such conveyance, transfer, sale or lease
is made shall succeed to, and be  substituted  for, and may exercise every right
and power of, the Company  under this  Security  with the same effect as if such
successor Person had been named as the Company herein, and thereafter, except in
the case of a lease, the predecessor Person shall be relieved of all obligations
and covenants under this Security.

          6.  Payment in Stock.  (a) The Company may elect to pay some or all of
the  Repurchase  Price by delivery of shares of Common Stock or shares of common
stock  in any  Person  succeeding  the  Company,  if and  only  if,  each of the
following  conditions shall be satisfied  (without limiting any other conditions
contained herein):

          (1) Any such payment shall be made in five equal installments, on each
of the five  consecutive  Trading Days ending on and including the third Trading
Day immediately preceding the date when any cash payment would otherwise be due,
and the  shares of Common  Stock or common  stock of any Person  succeeding  the
Company deliverable in payment of each such installment shall have a fair market
value as of the date of such  installment  of not less than 20% of the amount of
such payment due hereunder which is payable in shares of stock.  For purposes of
this  Section 6, the fair market  value of shares of Common Stock shall be equal
to 95% of the Closing Price for the immediately preceding Trading Day;

          (2) In the event any  shares  of Common  Stock or common  stock of any
Person  succeeding  the  Company  to be  issued in  respect  of any  amount  due
hereunder  require  registration  under any Federal  securities  law before such
shares  may be  freely  transferrable  without  being  subject  to any  transfer
restrictions under the Securities Act of 1933 upon

                                       23

<PAGE>


issuance,  such  registration  shall have been  completed  and shall have become
effective prior to the date of the first such installment;

          (3) In the event any  shares  of Common  Stock or common  stock of any
Person  succeeding  the  Company  to be  issued in  respect  of any  amount  due
hereunder require  registration  with or approval of any governmental  authority
under any State law or any other  Federal  law before such shares may be validly
issued or delivered upon issuance or transferred freely, such registration shall
have been  completed or have become  effective and such approval shall have been
obtained, in each case, prior to the date of the first such installment;

          (4)  The  shares  of  Common  Stock  or  common  stock  of any  Person
succeeding the Company deliverable in payment of such amount due hereunder shall
have been approved for quotation in the Nasdaq National Market immediately prior
to the date of the  first  such  installment  or,  if at the time its  shares of
Common Stock or shares of common stock of any Person  succeeding the Company are
listed or admitted for trading on any national securities  exchange,  the shares
of  Common  Stock or common  stock in any  Person  succeeding  the  Company  and
deliverable shall have been so listed or admitted for trading.

          (5)  All  shares  of  Common  Stock  or  common  stock  of any  Person
succeeding  the  Company  deliverable  in payment of such  amount due  hereunder
shall, upon issue, be duly and validly issued and fully paid and  non-assessable
and free of any preemptive rights;

          (6) In respect of each such payment date, the Company shall have given
the  holder of this  Security  not less than 10 nor more than 15  Trading  Days'
notice of its  election  to effect  payment in respect of such  payment  date by
delivery  of  shares  of  Common  Stock;  provided  that any such  notice  shall
accompany the Company's notice of a Change of Control relating thereto; and

          (7) The Company shall deliver,  or cause to be delivered a certificate
from the Person succeeding the Company which states, that after giving effect to
any  Change of  Control  that the  holding by the  Purchasers  or any  assignees
thereof of this Security,  or the holding of any Common Stock or common stock of
any Person  succeeding  the Company after  conversion of this Security would not
constitute a  prohibited  transaction  which would  violate the  prohibition  of
section  406 of ERISA or which  would  subject  any  "disqualified  person"  (as
defined in section  4975(e)(2)  of the Code) to a tax  pursuant to section  4975
(c)(1)(A)-(D) of the Code.

          If all of the  conditions  set  forth  in this  Section  6(a)  are not
satisfied in  accordance  with the terms  hereof,  any such amount due hereunder
shall be paid by the Company only in cash.

          (b) Any  issuance of shares of Common  Stock or shares of common stock
of any Person succeeding the Company in respect of any installment due hereunder
pursuant  to this  Section 6 shall be deemed to have been  effected  immediately
prior to the close of

                                       24

<PAGE>


business on the date of delivery of such  installment  and the person or persons
in whose  name or names any  certificate  or  certificates  for shares of Common
Stock shall be  issuable  upon such  delivery  shall be deemed to have become on
such date the holder or holders  of record of the  shares  represented  thereby;
provided,  however, that in case any installment shall be due on a date when the
stock  transfer  books of the Company shall be closed,  the person or persons in
whose name or names the  certificate or  certificates  for such shares are to be
issued shall be deemed to have become the record  holder or holders  thereof for
all purposes at the opening of business on the next succeeding day on which such
stock  transfer  books are open.  No  payment  or  adjustment  shall be made for
dividends or distributions on any Common Stock issued pursuant to this Section 6
declared prior to the relevant delivery date; and

          (c) Any  issuance and  delivery of  certificates  for shares of common
stock or shares of common stock of any Person succeeding the Company pursuant to
this Section 6 shall be made without  charge to the holder of this  Security for
such  certificates or for any tax or duty in respect of the issuance or delivery
of such certificates or the securities represented thereby.

          7. Other.  (a) No provision of this Security shall alter or impair the
obligation  of the  Company,  which is absolute  and  unconditional,  to pay the
principal  of,  premium,  if any, and  interest on this  Security in cash at the
times,  places and rate,  and in the coin or currency,  herein  prescribed or to
convert this Security as herein provided.

          (b) The  Company  will give  prompt  written  notice to the  holder of
Security of any change in the location of the Designated Office.

          (c) The  transfer of this  Security  is  registrable  on the  Security
Register of the Company upon  surrender of this  Security  for  registration  of
transfer at the Designated Office, duly endorsed by, or accompanied by a written
instrument of transfer in form satisfactory to the Company duly executed by, the
holder hereof or his attorney duly  authorized in writing,  and thereupon one or
more new  Securities,  of authorized  denominations  and for the same  aggregate
principal  amount,  will be issued to the designated  transferee or transferees.
Such  Securities  are  issuable  only in  registered  form  without  coupons  in
denominations  of $1,000 and any integral  multiple  thereof,  No service charge
shall be made for any such registration of transfer, but the Company may require
payment of a sum  sufficient  to recover  any tax or other  governmental  charge
payable in connection therewith.  Prior to due presentation of this Security for
registration of transfer, the Company and any agent of the Company may treat the
Person in whose name this  Security is  registered  as the owner thereof for all
purposes,  whether or not this Security be overdue,  and neither the Company nor
any such agent shall be affected by notice to the contrary.

          (d) The Company shall keep at the Designated Office a register for the
registration  and  registration of transfers of Convertible  Notes. The name and
address of each holder of one or more Convertible  Notes,  each transfer thereof
and the name and address of each  transferee  of one or more  Convertible  Notes
shall be registered in such register.  Prior to due presentment for registration
of transfer, the Person in whose name any Convertible Note

                                       25

<PAGE>


shall be registered  shall be deemed and treated as the owner and holder thereof
for all purposes hereof,  and the Company shall not be affected by any notice or
knowledge to the contrary. The Company shall give to any holder of a Convertible
Note  promptly upon request  therefor,  a complete and correct copy of the names
and addresses of all registered holders of Convertible Notes.

          (e) Upon surrender of any  Convertible  Note at the Designated  Office
for  registration  of transfer or exchange  (and in the case of a surrender  for
registration of transfer,  duly endorsed or accompanied by a written  instrument
of transfer duly executed by the registered  holder of such  Convertible Note or
his  attorney  duly  authorized  in writing and  accompanied  by the address for
notices  of each  transferee  of such  Convertible  Note or part  thereof),  the
Company shall execute and deliver,  at the Company's expense (except as provided
below),  one or more new Convertible  Notes (as requested by the holder thereof)
in exchange  therefor,  in an  aggregate  principal  amount  equal to the unpaid
principal amount of the surrendered  Convertible Note. Each such new Convertible
Note shall be payable to such  Person as such  holder may  request  and shall be
substantially in the form of this Security. Each such new Convertible Note shall
be dated and bear interest from the date to which  interest shall have been paid
on the  surrendered  Convertible  Note or  dated  the  date  of the  surrendered
Convertible  Note if no interest  shall have been paid thereon.  The Company may
require  payment  of a sum  sufficient  to cover any  stamp tax or  governmental
charge  imposed in respect of any such  transfer of this  Security.  Convertible
Notes shall not be transferred in denominations of less than $100,000,  provided
that if  necessary  to enable the  registration  of  transfer by a holder of its
entire  holding  of  Convertible  Notes,  one  Convertible  Note  may  be  in  a
denomination  of less than  $100,000.  Any  transferee,  by its  acceptance of a
Convertible  Note registered in its name (or the name of its nominee),  shall be
deemed  to have  made the  representation  set  forth in  Section  3 of the Note
Purchase Agreement.

          (f) Upon receipt by the Company of evidence reasonably satisfactory to
it of the ownership of and the loss,  theft,  destruction  or mutilation of this
Security  (which evidence shall be notice from such holder of such ownership and
such loss, theft, destruction or mutilation), and

          (i) in the case of loss, theft or destruction, of indemnity reasonably
     satisfactory  to it (provide) that if the holder of this Security is, or is
     a nominee for, an original holder or another institutional  investor holder
     of this Security,  such Person's own unsecured agreement of indemnity shall
     be deemed to be satisfactory), or

          (ii) in the  case  of  mutilation,  upon  surrender  and  cancellation
     thereof,

the Company at its own expense shall execute and deliver, in lieu thereof, a new
Convertible  Note,  dated and bearing  interest from the date to which  interest
shall have been paid on such lost,  stolen,  destroyed or mutilated  Convertible
Note or dated the date of such lost, stolen,  destroyed or mutilated Convertible
Note if no interest shall have been paid thereon.

                                       26

<PAGE>


          (G) THIS  SECURITY  SHALL BE GOVERNED BY AND  CONSTRUED IN  ACCORDANCE
WITH THE LAWS OF THE STATE OF NEW YORK, UNITED STATES OF AMERICA.

          (h) So long as you or your  nominee  shall be holder of this  Security
and notwithstanding  anything in this Security to the contrary, the Company will
pay all sums becoming due hereunder for principal,  Make-Whole  Amount,  if any,
and interest by the method and at the address  specified  for such purpose below
your name in Schedule I of the Note Purchase Agreement,  or by such other method
provided in the Preamble or at such other address as you shall have from time to
time  specified  to the  Company  in  writing  for  such  purpose,  without  the
presentation  or  surrender  of this  Security,  or the  making of any  notation
hereon,  except that upon written request of the Company made  concurrently with
or  reasonably  promptly  after  payment  in full of this  Security,  you  shall
surrender  this Security for  cancellation,  reasonably  promptly after any such
request to the  Company  at its  principal  executive  office or at the place of
payment most  recently  designated  by the  Company.  Prior to any sale or other
disposition of this Security you will, at your election,  either endorse thereon
the amount of  principal  paid  thereon and the last date to which  interest has
been paid  thereon or surrender  this  Security to the Company in exchange for a
new Convertible  Note pursuant to the terms hereof.  The Company will afford the
benefits of this  Section to any  institutional  investor  that is the direct or
indirect transferee of this Security.


                     [END OF PAGE - SIGNATURE PAGE FOLLOWS]




                                       27

<PAGE>


                    Signature Page of Note Purchase Agreement

for the purpose of implementing or effectuating the provisions contained herein,
in the Convertible Notes or in the Registration Rights Agreement.

                                                     Very truly yours,

                                                     CELGENE CORPORATION

                                                     By:/s/ Sol J. Barer
                                                        ------------------------
                                                        Name: Sol J. Barer
                                                        Title: Pres/COO






<PAGE>



       Signature Page of Note Purchase Agreement with Celgene Corporation

Accepted as of the date hereof:

JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------

JOHN HANCOCK VARIABLE LIFE INSURANCE COMPANY

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------

SIGNATURE 1A (CAYMAN), LTD.
By: John Hancock Mutual Life Insurance
         Company, Portfolio Advisor .

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------

Signature 3 Limited

  By: John Hancock Mutual Life Insurance Company,
         as Portfolio Advisor

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------

Hancock Mezzanine Partners L.P.
By: Hancock Mezzanine Investments LLC, its General Partner
By: John Hancock Mutual Life Insurance Company.
                           as Investment Manager

By:      /s/Stephen J. Blewitt
   -----------------------------------
Name:       Stephen J. Blewitt
     ---------------------------------
Title:      Senior Investment Officer
      --------------------------------


<PAGE>



                    ELECTION OF HOLDER TO REQUIRE REPURCHASE

     1. Pursuant to Section 3(a) of this Security, the undersigned hereby elects
to have all or a portion of this Security repurchased by the Company.

     2. The undersigned hereby directs the Company to pay [choose one] (a) it or
(b)  Name:  _______________________;  address:  _______________________;  Social
Security or Other Taxpayer Identification Number, if any: __________________, an
amount in cash or equal to 100% of the principal  amount to be  repurchased  (as
set forth below),  plus  interest  accrued to the  Repurchase  Date, as provided
herein.

                                            Dated:
                                                  ------------------------------

                                                  ------------------------------
                                                           Signature

Number of shares of Common Stock
owned by the holder and its affiliates:
                                       --------------------

Principal amount to be repurchased
(an integral multiple of $1,000):
                                       --------------------

Remaining principal amount following such repurchase
(not less than $1,000):
                                       --------------------

NOTICE:  The signature to the foregoing  Election must correspond to the name as
written upon the face of this Security in every particular,  without  alteration
or any change whatsoever.



<PAGE>


                                CONVERSION NOTICE

     The undersigned  holder of this Security hereby  irrevocably  exercises the
option to convert this Security,  or any portion of the principal  amount hereof
(which is an  integral  multiple  of $1,000)  below  designated,  into shares of
Common Stock  (subject to the  limitation  set forth in the second  paragraph of
Section 2(a) of the Security) in accordance with the terms of this Security, and
directs that such shares,  together  with a check in payment for any  fractional
share and any Security  representing any unconverted principal amount hereof, be
delivered to and be registered in the name of the undersigned unless a different
name has been indicated below. If shares of Common Stock or Securities are to be
registered in the name of a Person other than the  undersigned,  the undersigned
will pay all transfer taxes payable with respect thereto. Any amount required to
be paid by the undersigned on account of interest accompanies this Security.

Dated:
      ------------------------------              ------------------------------
                                                           Signature

Number of shares of Common Stock
owned by the holder and its affiliates:
                                       ------------------------------

If  shares  or  Securities  are  to be    If only a portion of the Securities is
registered  in the  name  of a  person    to be converted, please indicate:
other than the  holder,  please  print
such person's name and address:


                                          1.   Principal amount to be converted:

                                               $
- ------------------------------                  ------
           Name

                                          2.   Principal amount and denomination
                                               of     Security      representing
                                               unconverted  principal  amount to
                                               be issued:

- ------------------------------
         Address
                                               Amount: $__________

                                               Denominations: $__________
                                               (any integral multiple of $1,000)
- ------------------------------
Social Security or other Taxpayer
Identification Number, if any



<PAGE>


                                                                        ANNEX II

                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

     (a) Each of the  Company's  Annual  Report on Form 10-K for the year  ended
December 31, 1997, and each report filed by the Company pursuant to the Exchange
Act  after the  filing of such  Annual  Report on Form 10-K  (collectively,  the
"Exchange Act Reports")  conforms in all material respects with the requirements
of the Exchange Act and the rules and regulations of the Securities and Exchange
Commission  thereunder;  and no such  document,  when it was  filed  (or,  if an
amendment  with respect to any such document was filed,  when such amendment was
filed),  contained any untrue statement of a material fact or omitted to state a
material fact required to be stated  therein or necessary to make the statements
therein,  in the light of the  circumstances  under  which they were  made,  not
misleading.

     (b) All the  outstanding  shares of capital  stock of the Company have been
authorized  duly and validly issued and are fully paid,  non-assessable  and not
subject to any preemptive or similar rights;  the Shares initially issuable upon
conversion of the  Convertible  Notes have been duly and validly  authorized and
reserved for issuance out of the  Company's  authorized  and unissued  shares of
Common Stock and, when issued and delivered in accordance with the provisions of
the  Convertible  Notes  will  be  duly  and  validly  issued,  fully  paid  and
non-assessable and will conform to the description of the Common Stock contained
in the Company's Registration Statement on Form 8-A, File No. 0-16132.

     (c) The  Convertible  Notes has been duly  authorized  and, when issued and
delivered pursuant to this Agreement,  will have been duly executed,  issued and
delivered  and will  constitute a valid and legally  binding  obligation  of the
Company;  and the  Registration  Rights  Agreement has been duly authorized and,
when executed and delivered by the parties thereto,  will constitute a valid and
legally  binding  obligation of the Company,  enforceable in accordance with its
terms, subject, as to enforcement, to bankruptcy, insolvency, reorganization and
other laws of general  applicability  relating to or affecting creditors' rights
and to general equity principles.

     (d)  The  execution,  delivery  and  performance  of  this  Agreement,  the
Registration  Rights  Agreement  and the  Convertible  Notes,  compliance by the
Company  with all  provisions  hereof and  thereof and the  consummation  of the
transactions contemplated hereby or thereby and the issuance and delivery of the
Convertible  Notes will not conflict  with or  constitute a breach of any of the
terms or  provisions  of, or a default  under,  the  charter  or  by-laws of the
Company  or any of  its  Subsidiaries,  or any  agreement,  indenture  or  other
instrument to which it or any of its  Subsidiaries  is a party or by which it or
any of its Subsidiaries or their respective  properties are bound, or violate or
conflict with any laws,  administrative  regulations or rulings or court decrees
applicable to the Company, any of its subsidiaries or their respective property;
and, except (i) as required pursuant to the Registration  Rights  Agreement,  or
(ii) for the disclosure  required to be included in the Company's next Quarterly
Report on Form 10-Q, when filed, pursuant to Item 2(c) of Form 10-Q, no consent,
approval,  authorization  or order of or filing or  registration  with, any such
court or governmental agency or body is required for the execution, delivery and
performance of this Agreement, the Registration

                                        1

<PAGE>


Rights  Agreement and the Convertible  Notes by the Company and the consummation
of the transactions contemplated hereby and thereby.

     (e) Except as otherwise set forth in the Exchange Act Reports, there are no
material legal or governmental  proceedings  pending to which the Company or any
of its subsidiaries is a party or of which any of their  respective  property is
the subject which, if determined  adversely to the Company or its  subsidiaries,
might  have a  Material  Adverse  Effect,  and,  to the  best  of the  Company's
knowledge, no such proceedings are threatened or contemplated.

     (f) The Company is not, and the Company covenants that at any time when the
Convertible  Notes  are  outstanding  it will  not be,  an  open-end  investment
company, unit investment trust or face-amount  certificate company that is or is
required  to be  registered  under  Section 8 of the  United  States  Investment
Company Act of 1940, as amended.

     (g) When the  Convertible  Notes are issued and delivered  pursuant to this
Agreement,  the  Convertible  Notes  will not be of the same class  (within  the
meaning of Rule 144A under the Securities  Act of 1933) as securities  which are
listed on a  national  securities  exchange  registered  under  Section 6 of the
Exchange Act or quoted in a U.S. automated inter-dealer quotation system.

     (h) The Company is, and the Company  covenants  that while the  Convertible
Notes are  outstanding  it will  remain,  subject  to Section 13 or 15(d) of the
Exchange Act.

     (i) Neither the Company nor any person  acting on its behalf has offered or
sold the  Convertible  Notes by means of any  general  solicitation  or  general
advertising within the meaning of Rule 502(c) under the Act.

     (j) The Company is a corporation  duly organized,  validly  existing and in
good standing under the laws of its jurisdiction of  incorporation,  and is duly
qualified as a foreign  corporation and is in good standing in each jurisdiction
in which such  qualification is required by law, other than those  jurisdictions
as to which the  failure  to be so  qualified  or in good  standing  could  not,
individually  or in the  aggregate,  reasonably  be  expected to have a Material
Adverse Effect. The Company has the corporate power and authority to own or hold
under lease the  properties it purports to own or hold under lease,  to transact
the business it transacts and proposes to transact,  to execute and deliver this
Agreement and the Other Agreements and the Convertible  Notes and to perform the
provisions hereof and thereof.

     (k) The  Company,  through  its  agent,  Warburg,  Dillon,  Read  LLC,  has
delivered  to each  Purchaser a copy of a Private  Placement  Memorandum,  dated
December  1998 (the  "MEMORANDUM"),  relating to the  transactions  contemplated
hereby.  The "Executive  Summary",  "Investment  Highlights" and "Management and
Directors" sections of the Memorandum, when read together with Exhibits 1, 2 and
3 of the Memorandum,  fairly  describe,  in all material  respects,  the general
nature  of the  business  and  principal  properties  of  the  Company  and  its
Subsidiaries.  This Agreement,  the aforesaid sections of the Memorandum and the
documents,  certificates  or other writings  delivered to you by or on behalf of
the Company pursuant hereto

                                        2

<PAGE>


taken as a whole, do not contain any untrue statement of a material fact or omit
to state  any  material  fact  necessary  to make  the  statements  therein  not
misleading in light of the  circumstances  under which they were made. Except as
disclosed in the  Memorandum or in one of the documents,  certificates  or other
writings identified therein, or in the financial  statements  comprising part of
Exhibits 1, 2 or 3 of the Memorandum,  since September 30, 1998,  there has been
no  change in the  financial  condition,  operations,  business,  properties  or
prospects of the Company or any Subsidiary  except changes that  individually or
in the aggregate  could not  reasonably  be expected to have a Material  Adverse
Effect.  There is no fact known to the Company that could reasonably be expected
to have a Material  Adverse  Effect that has not been set forth herein or in the
Memorandum   (including  the  Exhibits  thereto)  or  in  the  other  documents,
certificates and other writings  delivered to you by or on behalf of the Company
specifically  for use in connection with the transactions  contemplated  hereby.
The projections referred to in the Memorandum in Section 4 were prepared in good
faith,  are based upon  assumptions  that the Company believes are reasonable to
make and, in good faith judgment of the Company,  take into account all Material
information  regarding the matters set forth therein. Such projections represent
a reasonable estimate by the Company of the future financial  performance of the
Company.  The Company does not presently  anticipate any Material deviation from
such  projections  and the  Company  reasonably  believes  that the  results  of
operations  reflected  therein  are  obtainable.  The  statements  of action the
Company  plans to take,  the  prediction  of  potential  sales  and  returns  on
investments  and  similar  statements  regarding  events to occur in the  future
contained in Section 2 of the Memorandum were made in good faith, are based upon
assumptions  that the  Company  believes  are  reasonable  to make and take into
account all Material information  regarding the matters set forth therein.  Such
statements  represent  a  reasonable  estimate  by the  Company  of  the  future
performance of the Company and are not statements of currently  existing  facts.
The Company does not presently anticipate any Material deviation from such plans
or predictions and the Company reasonably believes that the results suggested by
such predictions are obtainable.

     (1) No consent,  approval or authorization  of, or registration,  filing or
declaration with, any Governmental  Authority is required in connection with the
execution,  delivery  or  performance  by the Company of this  Agreement  or the
Convertible Notes.

     (m) (i) the  Company  and its  Subsidiaries  own or possess  all  licenses,
     permits, franchises,  authorizations,  patents, copyrights,  service marks,
     trademarks and trade names, or rights thereto,  that individually or in the
     aggregate are Material,  without known  conflict with the rights of others,
     except for those conflicts that  individually,  or in the aggregate,  would
     not have a Material Adverse Effect;

          (ii) to the best  knowledge of the Company,  no product of the Company
     infringes  in  any  material  respect  any  license,   permit,   franchise,
     authorization,  patent, copyright,  service mark, trademark,  trade name or
     other right owned by any other Person except for those  infringements which
     would  not  individually,  or in the  aggregate,  have a  Material  Adverse
     Effect; and

                                        3

<PAGE>


          (iii) to the  best  knowledge  of the  Company,  there is no  Material
     violation  by  any  Person  of  any  right  of  the  Company  or any of its
     Subsidiaries  with  respect  to  any  patent,   copyright,   service  mark,
     trademark, trade name or other fight owned or used by the Company or any of
     its Subsidiaries.

     (n) (i) The Company and each ERISA Affiliate have operated and administered
     each Plan in compliance  with all applicable laws except for such instances
     of  noncompliance  as have not  resulted  in and  could not  reasonably  be
     expected to result in a Material  Adverse  Effect.  Neither the Company nor
     any ERISA Affiliate has incurred any liability pursuant to Title I or IV of
     ERISA or the  penalty  or excise tax  provisions  of the Code  relating  to
     employee  benefit  plans (as defined in Section 3 of ERISA),  and no event,
     transaction  or condition  has occurred or exists that could  reasonably be
     expected to result in the  incurrence of any such  liability by the Company
     or any  ERISA  Affiliate,  or in the  imposition  of any Lien on any of the
     rights,  properties  or assets of the  Company or any ERISA  Affiliate,  in
     either case pursuant to Title I or IV of ERISA or to such penalty or excise
     tax provisions or to Section 401(a)(29) or 412 of the Code, other than such
     liabilities  or Liens  as would  not be  individually  or in the  aggregate
     Material.

          (ii) The present value of the aggregate benefit liabilities under each
     of the Plans subject to Title IV of ERISA (other than Multiemployer Plans),
     determined  as of the end of such Plan's most  recently  ended plan year on
     the basis of the actuarial  assumptions  specified for funding  purposes in
     such Plan's  most recent  actuarial  valuation  report,  did not exceed the
     aggregate  current  value of the  assets  of such  Plan  allocable  to such
     benefit  liabilities.  The  term  "benefit  liabilities"  has  the  meaning
     specified  in  section  4001 of ERISA and the  terms  "current  value"  and
     "present value" have the meaning specified in section 3 of ERISA.

          (iii)  The  Company  and  its  ERISA   Affiliates  have  not  incurred
     withdrawal  liabilities  (and  are not  subject  to  contingent  withdrawal
     liabilities)   under   section   4201  or  4204  of  ERISA  in  respect  of
     Multiemployer Plans that individually or in the aggregate are Material.

          (iv) The expected  postretirement benefit obligation (determined as of
     the last day of the Company's most recently ended fiscal year in accordance
     with Financial Accounting Standards Board Statement No. 106, without regard
     to liabilities  attributable to continuation  coverage  mandated by section
     4980B of the Code) of the Company and its Subsidiaries is not Material.

          (v) The execution and delivery of this  Agreement and the issuance and
     sale of the  Convertible  Notes  hereunder will not involve any transaction
     that  is  subject  to  the  prohibitions  of  section  406 of  ERISA  or in
     connection  with  which  a  tax  could  be  imposed   pursuant  to  section
     4975(c)(1)(A)-(D)  of the Code.  The  representation  by the Company in the
     first  sentence of this Section  Annex II n(v) is made in reliance upon and
     subject

                                        4

<PAGE>


     to the accuracy of the  representation  made by each Purchaser in Section 3
     of this  Agreement  as to the sources of the funds used to pay the purchase
     price of the Convertible Notes to be purchased by the Purchasers.

     (o) Neither  the  Company  nor anyone  acting on its behalf has offered the
Convertible Notes or any similar  securities for sale to, or solicited any offer
to buy any of the same from,  or otherwise  approached  or negotiated in respect
thereof  with,  any person  other than you,  the Other  Purchasers  and no other
Institutional Investors, each of which has been offered the Convertible Notes at
a private  sale for  investment.  Neither the  Company nor anyone  acting on its
behalf has taken,  or will take,  any action that would  subject the issuance or
sale of the Convertible  Notes to the registration  requirements of Section 5 of
the Securities Act.

     (p) No  part  of the  proceeds  from  the  sale  of the  Convertible  Notes
hereunder  will be used,  directly or  indirectly,  for the purpose of buying or
carrying  any margin  stock  within the meaning of  Regulation U of the Board of
Governors  of the  Federal  Reserve  System (12 CFR 221),  or for the purpose of
buying or carrying or trading in any securities  under such  circumstances as to
involve the Company in a violation of Regulation X of said Board (12 CFR 224) or
to involve any broker or dealer in a violation of Regulation T of said Board (12
CFR 220).  As used in this  Section,  the terms  "margin  stock" and "purpose of
buying or carrying" shall have the meanings  assigned to them in said Regulation
U.

     (q) Neither the sale of the Convertible  Notes by the Company hereunder nor
its use of the proceeds  thereof will violate the Trading with the Enemy Act, as
amended,  or any of the foreign assets control  regulations of the United States
Treasury  Department (31 CFR, Subtitle B, Chapter V, as amended) or any enabling
legislation or executive order relating thereto.

     (r) Neither the Company nor any  Subsidiary  has  knowledge of any claim or
has received any notice of any claim, and neither the Company nor any Subsidiary
has any knowledge of any proceeding that has been  instituted  raising any claim
against the Company or any of its  Subsidiaries or any of their  respective real
properties  now or  formerly  owned,  leased or operated by any of them or other
assets, alleging any damage to the environment or violation of any Environmental
Laws,  except,  in each case, such as could not reasonably be expected to result
in a Material Adverse Effect. Except as otherwise disclosed to you in writing,

          (i) neither the Company nor any  Subsidiary has knowledge of any facts
     which is reasonably likely to give rise to any claim, public or private, of
     violation  of  Environmental  Laws or damage to the  environment  emanating
     from, occurring on or in any way related to real properties now or formerly
     owned,  leased or  operated by the  Company or any  Subsidiary  or to their
     respective  assets or the use thereof,  except, in each case, such as could
     not reasonably be expected to result in a Material Adverse Effect;

          (ii)  neither the Company nor any of its  Subsidiaries  has stored any
     Hazardous  Materials on real  properties now or formerly  owned,  leased or
     operated by the Company

                                        5

<PAGE>


     or any  Subsidiary  and has not  disposed of any  Hazardous  Materials in a
     manner contrary to any Environmental  Laws, in each case in any manner that
     could reasonably be expected to result in a Material Adverse Effect; and

          (iii)  all  buildings  on all real  properties  now  owned,  leased or
     operated by the Company or any of its  Subsidiaries  are in compliance with
     applicable Environmental Laws, except where the failure to comply could not
     reasonably be expected to result in a Material Adverse Effect.

     (s) The Company  has (i)  initiated  a review and  assessment  of all areas
within its and each of its  Subsidiaries'  business  and  operations  (including
those  affected by  suppliers,  vendors and  customers)  that could be adversely
affected  by  the  "Year  2000  Problem"   (that  is,  the  risk  that  computer
applications  used by the  Company  or any of its  Subsidiaries  (or  suppliers,
vendors  and  customers)  may  be  unable  to  recognize  and  perform  properly
date-sensitive  functions  involving  certain  dates prior to and any date after
December 31, 1999),  (ii)  developed a plan and timeline for addressing the Year
2000  Problem on a timely  basis,  and (iii) to date,  implemented  that plan in
accordance with that  timetable.  Based on the foregoing,  the Company  believes
that  its  computer  applications  that  are  material  to  its  or  any  of its
Subsidiaries'  business and operations are reasonably expected on a timely basis
to be able to perform properly date-sensitive functions for all dates before and
after January 1, 2000 (that is, be "Year 2000 compliant"),  except to the extent
that a failure  to do so could  not  reasonably  be  expected  to have  Material
Adverse Effect. The Company is not aware that any of its suppliers,  vendors and
customers'  computer  applications  that are Material to the Company's or any of
its Subsidiaries'  business and operations are not expected on a timely basis to
be Year 2000 compliant.  The Company has requested a certificate from suppliers,
vendors and customers certifying that such Person is Year 2000 compliant.  As of
the date hereof, the Company has not received all of such certificates.

     All  representations  and  warranties  contained  herein shall  survive the
execution and delivery of this Note Purchase  Agreement,  the Convertible  Notes
and the Registration Rights Agreement, the purchase or transfer by a holder of a
Convertible  Note or any portion thereof or interest  therein and the payment of
any  Convertible  Note and may be  relied  upon by any  subsequent  holder  of a
Convertible  Note  regardless  of any  investigation  made at any  time by or on
behalf  of you  or any  other  holder  of a  Convertible  Note.  All  statements
contained in any  certificate or other  instrument  delivered by or on behalf of
the  Company   pursuant  to  this  Note  Purchase   Agreement  shall  be  deemed
representations   and  warranties  of  the  Company  under  this  Note  Purchase
Agreement.  Subject to the preceding sentence, this Note Purchase Agreement, the
Convertible  Notes, and the  Registration  Rights  Agreement,  embody the entire
agreement and understanding  between you and the Company and supersede all prior
agreements and understandings relating to the subject matter hereof.

                                        6

<PAGE>


                                                                       ANNEX III

                           OPINION OF COMPANY COUNSEL

     (a) The  Company  has been duly  incorporated,  is  validly  existing  as a
corporation in good standing under the laws of its jurisdiction of incorporation
and has the corporate  power and authority  required to carry on its business as
described  in the  Exchange  Act  Reports  and to own,  lease  and  operate  its
properties.

     (b) All the  outstanding  shares of Common Stock have been duly  authorized
and  validly  issued and are fully paid,  non-assessable  and not subject to any
preemptive or similar rights.

     (c) The Shares initially  issuable upon conversion of the Convertible Notes
have  been duly  authorized  and  reserved  for  issuance  and when  issued  and
delivered upon  conversion in accordance  with the provisions of the Convertible
Notes, will have been validly issued and will be fully paid and  non-assessable,
and the  issuance  of such Shares is not  subject to any  preemptive  or similar
rights.

     (d) This Note  Purchase  Agreement has been duly  authorized,  executed and
delivered by the Company and is enforceable in accordance with its terms.

     (e) The Convertible Notes have been duly authorized,  executed,  issued and
delivered,  and  constitutes  the valid and legally  binding  obligation  of the
Company  enforceable  in  accordance  with its  terms,  subject  to  bankruptcy,
insolvency, fraudulent transfer, reorganization,  moratorium and similar laws of
general applicability  relating to or affecting creditors' rights and to general
equity principles.

     (f) The Registration  Rights  Agreement has been duly authorized,  executed
and  delivered  by the  Company  and  constitutes  a valid and  legally  binding
agreement of the Company,  enforceable in accordance with its terms,  subject to
bankruptcy,  insolvency,  fraudulent  transfer,  reorganization,  moratorium and
similar laws of general applicability relating to or affecting creditors' rights
and to general  equity  principles;  provided  that such counsel need express no
opinion with respect to Section 6 of such Agreement.

     (g) The  authorized  capital  stock of the  Company,  including  the Common
Stock,  conforms as to legal matters to the description thereof contained in the
Company's Registration Statement on Form 8-A, File No. 0-16132.

     (h) Except (i) as required  pursuant to the Registration  Rights Agreement,
or (ii)  for the  disclosure  required  to be  included  in the  Company's  next
Quarterly  Report on Form 10-Q, when filed,  pursuant to Item 2(c) of Form 10-Q,
no consent, approval,  authorization or order of or filing or registration with,
any court or governmental agency or body is required for the execution, delivery
and performance of this Agreement,  the  Registration  Rights  Agreement and the
Convertible  Notes  by the  Company  and the  consummation  of the  transactions
contemplated by this Agreement and thereby.

     (i)  The  execution,  delivery  and  performance  of  this  Agreement,  the
Registration  Rights  Agreement  and  the  Convertible  Notes  by  the  Company,
compliance by the Company with all the

                                       1

<PAGE>


provisions   hereof  and  thereof  and  the  consummation  of  the  transactions
contemplated hereby and thereby will not conflict with or constitute a breach of
any of the terms or provisions of, or a default under, the charter or by-laws of
the Company or any agreement, indenture or other instrument to which the Company
is a party or by which the Company or its  properties  are bound,  or violate or
conflict with any laws,  administrative  regulations or rulings or court decrees
applicable  to the  Company or its  properties  in any case which is  reasonably
likely to have a Material Adverse Effect.

     (j)  The  Company  is not and is not  controlled  by a  company  that is an
open-end  investment company,  unit investment trust or face-amount  certificate
company that is or is required to be  registered  under  Section 8 of the United
States Investment Company Act of 1940, as amended.

     (k) Assuming  that the proceeds are used in  accordance  with the Officers'
Certificate,  no part of the proceeds of the sale of the Convertible  Notes will
be used  directly  or  indirectly  to  purchase,  acquire  or carry any  "margin
security" or "margin  stock" as such terms are used in  Regulation U, X and T of
the Board of Governors of the Federal Reserve System 12 C.F.R. Parts 221,224 and
220 respectively.

                          ['33 Act and '39 Act opinion]

                                  [litigation]


                                        2

<PAGE>


                                   SCHEDULE I
                                   Cover Page

<TABLE>
<CAPTION>
          Payee                                             Amount                    No.
          -----                                             ------                    ---
<S>                                                       <C>                         <C>
John Hancock Mutual Life Insurance                        $2,100,000                  R-1
Company

John Hancock Mutual Life Insurance                        $2,000,000                  R-2
Company

John Hancock Mutual Life Insurance                          $200,000                  R-3
Company

John Hancock Variable Life Insurance                        $200,000                  R-4
Company

John Hancock Mutual Life Insurance                          $500,000                  R-5
Company

Signature lA (Cayman), Ltd.                                 $500,000                  R-6
(nominee: Barnett & Co.)

Signature 3 Limited                                       $2,000,000                  R-7
(nominee: Hare & Co.)

Hancock Mezzanine Partners L.P.                           $7,500,000                  R-8
</TABLE>



<PAGE>


                                   SCHEDULE I
                   JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY

     $2,100,000 GENERAL ACCOUNT
     $2,000,000 GUARANTEED BENEFIT SUB ACCOUNT
     $200,000 SEPARATE ACCOUNT 12

1.   All payments on account of the  Convertible  Notes or other  obligations in
     accordance with the provisions  thereof shall be made by bank wire transfer
     of immediately  available funds for credit,  not later than 12 noon, Boston
     time, to:

         BankBoston
         ABA No. 011000390
         Boston, Massachusetts 02110
         Account of:      John Hancock Mutual Life Insurance Company
                          Private Placement Collection Account

         Account Number: 541-55417
         On Order of: Celgene Corporation [PPN No.]o
         Celgene Corporation 9.00% Senior Convertible Notes due January 20, 2004

2.   Contemporaneous with the above wire transfer, advice setting forth:

          (1)  the full name, interest rate and maturity date of the Convertible
               Notes or other obligations;
          (2)  allocation  of payment  between  principal  and  interest and any
               special payment; and
          (3)  name and address of Bank (or  Trustee)  from which wire  transfer
               was sent shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager

                                     1 of 12

<PAGE>


                     Investment Accounting Division, B-3
          Fax: 617-572-0628

4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention:    Bond and Corporate Finance Group, T-57
          Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention:    Investment Law Division, T-50
          Fax: 617-572-9268

6.   All securities shall be registered in the name of: John Hancock Mutual Life
     Insurance Company

7.   Tax I.D. No. 04-1414660


                                     2 of 12

<PAGE>


                  JOHN HANCOCK VARIABLE LIFE INSURANCE COMPANY
                                    $200,000

1.   All payments on account of the  Convertible  Notes or other  obligations in
     accordance with the provisions  thereof shall be made by bank wire transfer
     of immediately  available funds for credit,  not later than 12 noon, Boston
     time, to:

         BankBoston
         ABA No. 011000390
         Boston, Massachusetts 02110
         Account of:       John Hancock Mutual Life Insurance Company
                           Private Placement Collection Account

         Account Number: 541-55417
         On Order of: Celgene Corporation [PPN No.]
         Celgene Corporation 9.00% Senior Convertible Notes due January 20, 2004

2.   Contemporaneous with the above wire transfer, advice setting forth:

          (1)  the full name, interest rate and maturity date of the Convertible
               Notes or other obligations;
          (2)  allocation  of payment  between  principal  and  interest and any
               special payment; and
          (3)  name and address of Bank (or  Trustee)  from which wire  transfer
               was sent shall be delivered or fixed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628


                                     3 of 12

<PAGE>


4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Bond and Corporate Finance Group, T-57
          Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention:    Investment Law Division, T-50
          Fax: 617-572-9268

6.   All  securities  shall be registered in the name of: John Hancock  Variable
     Life Insurance Company

7.   Tax I.D. No. 04-2664016




                                    4 of 12

<PAGE>


                   JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY
                                    $500,000
                               SEPARATE ACCOUNT 18

1.   All payments on account of the  Convertible  Notes or other  obligations in
     accordance with the provisions  thereof shall be made by bank wire transfer
     of immediately  available funds for credit,  not later than 12 noon, Boston
     time, to:

         Investors Bank & Trust Company
         Boston, Massachusetts 02110 ABA No. 011001438
         Account Number: 79650-9107
         for further credit to Separate Account 18, Account 99266
         On Order of: Celgene Corporation [PPN No.]
         Celgene Corporation 9.00% Senior Convertible Notes due January 20, 2004

2.   Contemporaneous with the above wire transfer, advice setting forth:

          (1)  the full name, interest rate and maturity date of the Convertible
               Notes or other obligations;
          (2)  allocation  of payment  between  principal  and  interest and any
               special payment; and
          (3)  name and address of Bank (or  Trustee)  from which wire  transfer
               was sent shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628


                                     5 of 12

<PAGE>


4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention:    Bond and Corporate Finance Group, T-57
          Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention:    Investment Law Division, T-50
          Fax: 617-572-9268

6.   All securities shall be registered in the name of: John Hancock Mutual Life
     Insurance Company

7.   Tax I.D. No. 04-1414660





                                     6 of 12


<PAGE>


                           SIGNATURE lA (CAYMAN), LTD.
                                    $500,000

1.   All payments on account of the  Convertible  Notes or other  obligations in
     accordance with the provisions  thereof shall be made by bank wire transfer
     of immediately  available funds for credit,  not later than 12 noon, Boston
     time, to:

          Bankers Trust Company
          ABA #021-001-033 Acct. #99-911-145
          For further credit to: Bankers Trust Company, as Indenture Trustee for
               Signature lA (Cayman), Ltd., Account #98016

2.   Contemporaneous with the above wire transfer, advice setting forth:

          (1)  the full name, interest rate and maturity date of the Convertible
               Notes or other obligations;
          (2)  allocation  of payment  between  principal  and  interest and any
               special payment; and
          (3)  name and address of Bank (or  Trustee)  from which wire  transfer
               was sent, shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          Company, Portfolio Advisor
          200 Clarendon Street
          Boston, MA 02117
          Attention: George H. Braun
                     Bond and Corporate Finance Group, T-57
          Fax: 617-572-1605

          with a copy to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          Company, Portfolio Advisor
          200 Clarendon Street
          Boston, MA 02117

                                     7 of 12


<PAGE>


          Attention: George H. Braun
                     Bond and Corporate Finance Group, T-57
          Fax: 617-572-1605

          with a copy to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          Company, Portfolio Advisor
          200 Clarendon Street
          Boston, MA 02117
          Attention: George H. Braun
                     Bond and Corporate Finance Group, T-57
          Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Investment Law Division, T-50
          Fax: 617-572-9268

6.   Execution documents shall be executed as follows:

          SIGNATURE lA (CAYMAN), LTD.
          By: John Hancock Mutual Life Insurance
                   Company, Portfolio Advisor

          By:
             ----------------------------------------
          Title:
                -------------------------------------
                  [authorized John Hancock Officer]

7.   All securities shall be registered in the name of: BARNETT & CO.


                                     8 of 12

<PAGE>


                         SIGNATURE 3 LIMITED $2,000,000

1.   All payments on account of the  Convertible  Notes or other  obligations in
     accordance with the provisions  thereof shall be made by bank wire transfer
     of immediately  available funds for credit,  not later than 12 noon, Boston
     time, to:

         Investors Bank & Trust Company
         Boston, Massachusetts 02110
         ABA No. 011001438
         Account Number: 796509107
         for further credit to Signature 3 Limited, Account 99292
         On Order of: Celgene Corporation [PPN No.]
         Celgene Corporation 9.00% Senior Convertible Notes due January 20, 2004

2.   Contemporaneous with the above wire transfer, advice setting forth:

          (1)  the full name, interest rate and maturity date of the Convertible
               Notes or other obligations;
          (2)  allocation  of payment  between  principal  and  interest and any
               special payment; and
          (3)  name and address of Bank (or  Trustee)  from which wire  transfer
               was sent shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street

                                     9 of 12


<PAGE>


          Boston, MA 02117
          Attention:    Bond and Corporate Finance Group, T-57
          Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Investment Law Division, T-50
          Fax: 617-572-9268

6.   Execution documents shall be executed as follows:

          Signature 3 Limited

          By: John Hancock Mutual Life Insurance Company,
                   as Portfolio Advisor

          By:
             ----------------------------------------
                   [authorized John Hancock Officer]

7.   All securities shall be registered in the name of: Hare & Co.

8.   Tax I.D. No.: Not Applicable.


                                    10 of 12

<PAGE>


                         HANCOCK MEZZANINE PARTNERS L.P.
                                   $7,500,000

1.   All  payments on account of the Notes or other  obligations  in  accordance
     with  the  provisions  thereof  shall  be  made by bank  wire  transfer  of
     immediately  available  funds for  credit,  not later than 12 noon,  Boston
     time, to:

         Investors Bank & Trust Company
         Boston, Massachusetts 02110
         ABA No. 011001438
         Account Number: 58215013
         for further credit to Hancock Mezzanine Partners L.P., Account 99274
         On Order of: Celgene Corporation [PNN No.]
         Celgene Corporation 9.00% Senior Convertible Notes due January 20, 2004

2.   Contemporaneous with the above wire transfer, advice setting forth:

          (1)  the full name,  interest  rate and maturity  date of the Notes or
               other obligations;
          (2)  allocation  of payment  between  principal  and  interest and any
               special payment; and
          (3)  name and address of bank (or  Trustee)  from which wire  transfer
               was sent shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager
                     Investment Accounting Division, B-3
          Fax: 617-572-0628

4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street


                                    11 of 12

<PAGE>


          Boston, MA 02117
          Attention:    Bond and Corporate Finance Group, T-57
          Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention:    Investment Law Division, T-50
          Fax: 617-572-9268

6.   Execution documents shall be executed as follows:

          Hancock Mezzanine Partners L.P.
          By: Hancock Mezzanine Investments LLC, its General Partner
          By: John Hancock Mutual Life Insurance Company.
                  as Investment Manager

          By:
             ----------------------------------------
                 [authorized John Hancock Officer]

7.   All  securities  shall be  registered  in the name  of:  Hancock  Mezzanine
     Partners L.P.

8.   Tax I.D. No. 04-3428544


                                    12 of 12




                  THIS   SECURITY  AND  THE  COMMON  STOCK   ISSUABLE  UPON  ITS
CONVERSION  HAVE NOT BEEN REGISTERED  UNDER THE U.S.  SECURITIES ACT OF 1933, AS
AMENDED  (THE  "SECURITIES  ACT"),  AND MAY NOT BE  OFFERED,  SOLD,  PLEDGED  OR
OTHERWISE   TRANSFERRED   EXCEPT   PURSUANT  TO  AN  AVAILABLE   EXEMPTION  FROM
REGISTRATION  UNDER THE  SECURITIES  ACT AND IN ACCORDANCE  WITH ALL  APPLICABLE
SECURITIES LAWS OF THE STATES OF THE UNITED STATES AND OTHER JURISDICTIONS.

                               CELGENE CORPORATION

               9.00% SENIOR CONVERTIBLE NOTE DUE JANUARY 20, 2004

PPN No.:                                                              $2,100,000
No. R-1

                  CELGENE CORPORATION, a corporation duly organized and existing
under the laws of Delaware (the "Company") for value  received,  hereby promises
to pay to JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY, or registered assigns, the
principal  sum of TWO MILLION  ONE  HUNDRED  THOUSAND  DOLLARS  ($2,100,000)  on
January 20, 2004 and to pay interest thereon, from January 20, 1999, or from the
most  recent  interest  payment  date to which  interest  has been  paid or duly
provided for,  semiannually  on January 20 and July 20 in each year,  commencing
July 20, 1999,  at the rate of 9.00% per annum,  until the  principal  hereof is
due, and at the rate of 11.00% per annum on any overdue  principal  and premium,
if any,  and,  to the extent  permitted  by law, on any  overdue  interest.  The
interest so payable,  and punctually  paid or duly provided for, on any interest
payment  date will be paid to the person in whose name this  Security (or one or
more  predecessor  Securities)  is  registered  at the close of  business on the
regular  record date for such  interest,  which shall be the January 1 or July 1
(whether  or not a  Business  Day),  as the case  may be,  next  preceding  such
interest  payment date.  Payment of the  principal of (and premium,  if any, on)
this Security  shall be made upon the surrender of this Security to the Company,
at its office at 7 Powder Horn  Drive,  Warren,  NJ 07059 (or such other  office
within  the  United  States as shall be  notified  by the  Company to the holder
hereof) (the "Designated Office"), in such coin or currency of the United States
of America as at the time of payment  shall be legal  tender for the  payment of
public and private debts, by transfer to a U.S. dollar account maintained by the
payee with a bank in the United  States of America.  Payment of interest on this
Security shall be made by wire transfer to a U.S.  dollar account  maintained by
the payee  with a bank in the United  States of  America,  provided  that if the
holder shall not have furnished wire  instructions  in writing to the Company no
later than the record date relating to an interest  payment  date,  such payment
may be made by U.S.  dollar check  mailed to the address of the Person  entitled
thereto as such address  shall  appear in the Company  security  register.  This
Security  will rank pari passu with all existing  and future  senior debt of the
Company.


<PAGE>

         This Security is one of the Company's  9.00% Senior  Convertible  Notes
due January 20, 2004,  limited to  $15,000,000.00  aggregate  principal  amount,
issued  pursuant to that certain Note Purchase  Agreement dated January 20, 1999
(such agreements,  as amended,  modified and supplemented from time to time, the
"Note Purchase Agreement") between the Company and the Purchasers named therein,
and  the  holder  hereof  is  entitled  to the  benefits  of the  Note  Purchase
Agreement,  and may  enforce  the  agreements  contained  herein and therein and
exercise the remedies provided for hereby and thereby or otherwise  available in
respect hereof and thereof, all in accordance with the terms hereof and thereof.

                  1. Optional Redemption With Premium.  This Security is subject
to  redemption  upon not less than 30 nor more than 60 days' notice by mail,  at
any time on or after  January 20,  2001,  as a whole or in part,  (in any amount
that is an integral  multiple of $1000) at the  election  of the  Company,  at a
redemption  price of 103% the principal  amount  thereof,  together with accrued
interest to the redemption date, but interest installments whose stated maturity
is on or prior to such  redemption  date will be  payable  to the holder of this
Security,  or one or more  predecessor  Securities,  of  record  at the close of
business on the relevant record dates referred to on the face hereof;  provided,
however,  that the Company  may not redeem this  Security on or prior to January
20,  2002  unless the  Closing  Price of the Common  Stock  exceeds 225 % of the
Conversion Price for each Trading Day in a period of 20 Consecutive Trading Days
commencing not earlier than January 20, 2001. The term "Conversion Price" on any
day shall equal  $1,000  divided by the  Conversion  Rate in effect on each such
day.

                  2. Conversion.  (a) The holder of this Security is entitled at
any time on or after  January  20,  2000 and  before  the close of  business  on
January 20, 2004 (or,  in case this  Security or a portion  hereof is called for
redemption  or the holder  hereof has exercised its right to require the Company
to  repurchase  this  Security  or a portion  hereof,  then in  respect  of this
Security or such portion  hereof,  as the case may be, until and including,  but
(unless the  Company  defaults  in making the  payment  due upon  redemption  or
repurchase,  as the  case  may be) not  after,  the  close  of  business  on the
redemption  date or the  Repurchase  Date,  as the case may be) to convert  this
Security  (or any  portion of the  principal  amount  hereof that is an integral
multiple of $1,000),  into fully paid and nonassessable shares (calculated as to
each  conversion to the nearest 1/100 of a share) of Common Stock of the Company
at the rate of 55.56 shares of Common Stock for each $1,000  principal amount of
Security  (or at the current  adjusted  rate if an  adjustment  has been made as
provided  below) (the  "Conversion  Rate") by surrender of this  Security,  duly
endorsed or assigned to the Company or in blank to the Company at the Designated
Office,  accompanied  by written  notice to the Company  that the holder  hereof
elects to convert  this  Security (or if less than the entire  principal  amount
hereof is to be converted,  specifying the portion hereof to be converted). Upon
surrender  of this  Security  for  conversion,  the holder  will be  entitled to
receive the interest  accruing on the  principal  amount of this  Security  then
being  converted from the interest  payment date next preceding the date of such
conversion to such date of conversion. No payment or adjustment is to be made on
conversion for dividends on the

                                        2


<PAGE>



Common  Stock  issued on  conversion  hereof.  No  fractions  of shares or scrip
representing  fractions of shares will be issued on  conversion,  but instead of
any fractional  interest,  the Company shall pay a cash adjustment,  computed on
the basis of the Closing  Price of the Common  Stock on the date of  conversion,
or, at its option,  the Company  shall round up to the next higher  whole share.
This Security  shall be deemed to have been converted  immediately  prior to the
close of business on the day of surrender  hereof for conversion,  in accordance
with the foregoing provisions, and at such time the rights of the holder hereof,
as a holder hereof,  shall cease,  and the Person or Persons entitled to receive
the Common Stock  issuable on conversion  shall be treated by all Persons as the
holder or holders of such Common Stock at such time. Upon any partial conversion
of this Security,  the Company, at its expense, will forthwith issue and deliver
to,  or  upon  the  order  of the  holder  hereof,  a new  Convertible  Note  or
Convertible Notes in principal amount equal to the unconverted  principal amount
of such surrendered  Convertible  Note, such new Convertible Note or Convertible
Notes to be dated and to bear interest from the date to which  interest has been
paid on such surrendered Convertible Note.

                  As promptly as possible after the conversion of this Security,
in whole or in part,  and in any  event  within  ten (10) days  thereafter,  the
Company,  at its expense,  will issue and deliver a certificate or  certificates
for the number of full shares of Common Stock issuable upon such conversion.

                  (b) The Conversion  Rate shall be subject to adjustments  from
time to time as follows:

                  (1) In case the Company  shall pay or make a dividend or other
         distribution  on any class of capital  stock of the Company  payable in
         shares of Common Stock, the Conversion Rate in effect at the opening of
         business on the day following the Determination  Date for such dividend
         or other  distribution  shall be increased by dividing such  Conversion
         Rate by a fraction of which the numerator shall be the number of shares
         of  Common  Stock   outstanding  at  the  close  of  business  on  such
         Determination  Date and the denominator shall be the sum of such number
         of shares and the total number of shares  constituting such dividend or
         other distribution, such increase to become effective immediately after
         the opening of business on the day following such  Determination  Date.
         For the purposes of this  paragraph (1), the number of shares of Common
         Stock at any time  outstanding  shall not  include  shares  held in the
         treasury of the Company but shall include shares issuable in respect of
         scrip  certificates  issued  in lieu of  fractions  of shares of Common
         Stock.  The Company will not pay any dividend or make any  distribution
         on shares of Common Stock held in the treasury of the Company.

                  (2)  Subject to the last  sentence  of  paragraph  (7) of this
         Section 2(b), in case the Company shall issue rights, options, warrants
         or convertible  securities  entitling the holders  thereof to subscribe
         for or purchase shares of Common Stock at a


<PAGE>



price per share less than the  current  market  price per share  (determined  as
provided  in  paragraph  (8) of this  Section  2(b)) of the Common  Stock on the
Determination Date for such  distribution,  the Conversion Rate in effect at the
opening of business  on the day  following  such  Determination  Date,  shall be
increased by dividing such  Conversion Rate by a fraction of which the numerator
shall be the  number  of  shares of  Common  Stock  outstanding  at the close of
business on such  Determination  Date plus the number of shares of Common  Stock
which the  aggregate  amount  received by the Company  upon the issuance of such
rights,  options,  warrants or convertible  securities plus the aggregate amount
receivable  by the Company  upon the  exercise  or  conversion  of such  rights,
options,  warrants or  convertible  securities  would  purchase at such  current
market price and the  denominator  shall be the number of shares of Common Stock
outstanding at the close of business on such  Determination Date plus the number
of shares of Common Stock so offered for subscription or purchase, such increase
to  become  effective  immediately  after the  opening  of  business  on the day
following such Determination  Date provided,  that no such adjustment need to be
made in the case of the granting by the Company to employees or directors of the
Company or consultants to the Company of Common Stock and/or options to purchase
Common Stock and the issuance of Common Stock upon the exercise of such options.
For the purposes of this  paragraph (2), the number of shares of Common Stock at
any time  outstanding  shall not  include  shares  held in the  treasury  of the
Company  but shall  include  shares  issuable  in respect of scrip  certificates
issued in lieu of  fractions  of shares of Common  Stock.  The Company  will not
issue any rights,  options,  warrants or  convertible  securities  in respect of
shares of Common Stock held in the treasury of the Company.

         (3) In case outstanding shares of Common Stock shall each be subdivided
into a greater number of shares of Common Stock,  the Conversion  Rate in effect
at the  opening  of  business  on the day  following  the day  upon  which  such
subdivision   becomes  effective  shall  be  proportionately   increased,   and,
conversely,  in case  outstanding  shares of Common Stock shall each be combined
into a smaller number of shares of Common Stock,  the Conversion  Rate in effect
at the  opening  of  business  on the day  following  the day  upon  which  such
combination becomes effective shall be proportionately reduced, such increase or
reduction, as the case may be, to become effective immediately after the opening
of  business  on the day  following  the day  upon  which  such  subdivision  or
combination becomes effective.

         (4) Subject to the last sentence of paragraph (7) of this Section 2(b),
in case the Company shall, by dividend or otherwise, distribute evidences of its
indebtedness, shares of any class of capital stock, or other property (including
securities,  but  excluding  (i) any rights,  options,  warrants or  convertible
security  referred to in paragraph (2) of this Section 2(b) (ii) any dividend or
distribution  paid  exclusively  in cash,  (iii) any  dividend  or  distribution
referred  to in  paragraph  (1) of this  Section  2(b) and (iv)  any  merger  or
consolidation to which Section 2(h) applies),

                                        4


<PAGE>



the  Conversion  Rate shall be  adjusted  so that the same shall  equal the rate
determined by dividing the Conversion  Rate in effect  immediately  prior to the
close of business on the Determination  Date for such distribution by a fraction
of which the numerator  shall be the current market price per share  (determined
as provided in paragraph  (8) of this Section  2(b)) of the Common Stock on such
Determination  Date less the then fair market value (as determined in good faith
by the Board of Directors  of the Company) of the portion of the assets,  shares
or evidences of  indebtedness  so distributed  applicable to one share of Common
Stock and the  denominator  shall be such current  market price per share of the
Common Stock,  such  adjustment  to become  effective  immediately  prior to the
opening of business on the day following such Determination Date provided,  that
no such adjustment  need be made in the case of an underwritten  public offering
of Common  Stock in which the shares of Common Stock are sold to the public at a
price per share  equal to or in excess of 95% of the  market  price per share of
the  Common  Stock as of the date of the  pricing  of such  underwritten  public
offering.  If the Board of  Directors  determines  the fair market  value of any
distribution  for purposes of this  paragraph  (4) by reference to the actual or
when issued trading market for any securities  comprising such distribution,  it
must in doing so consider the prices in such market over the same period used in
computing the current  market price per share  pursuant to paragraph (8) of this
Section 2(b).

         (5) In case the Company  shall,  by dividend or otherwise,  make a Cash
Distribution,  then,  and in each  such  case,  immediately  after  the close of
business on the Determination  Date for such Cash  Distribution,  the Conversion
Rate shall be  adjusted  so that the same  shall  equal the rate  determined  by
dividing  the  Conversion  Rate in  effect  immediately  prior  to the  close of
business on such  Determination  Date by a fraction  (a) the  numerator of which
shall be equal to the current market price per share  (determined as provided in
paragraph  (8) of this Section  2(b)) of the Common Stock on such  Determination
Date  less an  amount  equal to the  quotient  of (1) the  amount  of such  Cash
Distribution  divided by (2) the number of shares of Common Stock outstanding on
such  Determination  Date and (b) the denominator of which shall be equal to the
current market price per share  (determined as provided in paragraph (8) of this
Section 2(b)) of the Common Stock on such Determination Date.

         (6) In case the Company or any Subsidiary shall make an Excess Purchase
Payment,  then,  and in each such  case,  immediately  prior to the  opening  of
business  on the day after the tender  offer in  respect  of which  such  Excess
Purchase Payment is to be made expires, the Conversion Rate shall be adjusted so
that the same shall equal the rate determined by dividing the Conversion Rate in
effect  immediately prior to the close of business on the Determination Date for
such tender offer by a fraction (a) the numerator of which shall be equal to the
current market price per share  (determined as provided in paragraph (8) of this
Section  2(b)) of the  Common  Stock on such  Determination  Date less an amount
equal to the quotient of (A) the Excess Purchase


<PAGE>



Payment  divided  by (B) the  number  of  shares  of  Common  Stock  outstanding
(including any tendered shares) as of the Determination  Date less the number of
all shares validly tendered and not withdrawn as of the  Determination  Date and
(b) the  denominator  of which  shall be equal to the current  market  price per
share  (determined  as provided in paragraph  (8) of this  Section  2(b)) of the
Common Stock as of such Determination Date.

         (7) The  reclassification  of Common Stock into  securities  other than
Common Stock (other than any reclassification  upon a consolidation or merger to
which Section 2(h)  applies)  shall be deemed to involve (a) a  distribution  of
such securities  other than Common Stock to all holders of Common Stock (and the
effective date of such reclassification  shall be deemed to be the Determination
Date),  and (b) a subdivision or combination,  as the case may be, of the number
of shares of Common Stock outstanding immediately prior to such reclassification
into the number of shares of Common  Stock  outstanding  immediately  thereafter
(and the effective date of such reclassification  shall be deemed to be "the day
upon  which  such  subdivision  becomes  effective"  or "the day upon which such
combination becomes effective", as the case may be, and "the day upon which such
subdivision or combination  becomes  effective"  within the meaning of paragraph
(3) of this Section 2(b)). Rights,  options,  warrants or convertible securities
issued by the Company entitling the holders thereof to subscribe for or purchase
shares  of  Common  Stock,  which  rights,  options,   warrants  or  convertible
securities  (i) are deemed to be  transferred  with such shares of Common Stock,
(ii) are not  exercisable  and  (iii)  are also  issued  in  respect  of  future
issuances of Common  Stock,  in each case in clauses (i) through (iii) until the
occurrence of a specified event or events ("Trigger Event"),  shall for purposes
of this Section 2(b) not be deemed  issued until the  occurrence of the earliest
Trigger Event.

         (8)  Except  as  otherwise  provided  in  the  last  sentence  of  this
subsection  (8) of  Section  2(b)  for  the  purpose  of any  computation  under
paragraphs  (2),  (4), (5) or (6) of this Section 2(b) the current  market price
per share of Common Stock on any date shall be  calculated by the Company and be
deemed  to be the  average  of  the  daily  Closing  Prices  for  the  five  (5)
consecutive  Trading Days selected by the Company  commencing  not more than ten
(10) Trading Days before,  and ending not later than,  the earlier of the day in
question  and the day  before  the "ex date" with  respect  to the  issuance  or
distribution  requiring such  computation.  For purposes of this paragraph,  the
term "ex date",  when used with respect to any issuance or  distribution,  means
the first date on which the Common  Stock trades  regular way in the  applicable
securities market or on the applicable  securities exchange without the right to
receive such issuance or distribution.  The current market price with respect to
any option  issued to any employee or director of the Company or  consultant  to
the Company  shall be the fair market value on the date of grant  determined  by
reference  to the market  price on the day of the grant of such option or to the
market price at the close of business on the Trading Day  immediately  preceding
such grant.

                                        6

<PAGE>



                  (9) No  adjustment  in the  Conversion  Rate shall be required
         unless such  adjustment  (plus any  adjustments  not previously made by
         reason of this  paragraph (9)) would require an increase or decrease of
         at  least  one  percent  in such  rate;  provided,  however,  that  any
         adjustments  which by reason of this  paragraph (9) are not required to
         be made  shall  be  carried  forward  and  taken  into  account  in any
         subsequent  adjustment.  All calculations under this Section 2 shall be
         made to the nearest cent or to the nearest one-hundredth of a share, as
         the case may be.

                  (10) The Company  may make such  increases  in the  Conversion
         Rate,  for the remaining term of the Securities or any shorter term, in
         addition to those  required by  paragraphs  (1), (2), (3), (4), (5) and
         (6) of this  Section  2(b) as it  considers to be advisable in order to
         avoid or  diminish  any income  tax to any  holders of shares of Common
         Stock  resulting from any dividend or distribution of stock or issuance
         of rights,  options,  warrants or convertible securities to purchase or
         subscribe  for stock or from any event  treated  as such for income tax
         purposes.

                  (c)  Whenever the  Conversion  Rate is adjusted as provided in
Section  2(b),  the  Company  shall  compute  the  adjusted  Conversion  Rate in
accordance  with Section 2(b) and shall prepare a certificate  (the  "Conversion
Rate Certificate") signed by the Senior Financial Officer of the Company setting
forth the adjusted  Conversion  Rate and showing in reasonable  detail the facts
upon which such adjustment is based, and shall promptly deliver such certificate
to the holder of this Security.  If the holders of the Convertible Notes and the
Company cannot agree in writing as to the adjusted Conversion Rate in accordance
with Section 2(b),  the holders of the  Convertible  Notes and the Company shall
determine  the  adjusted  Conversion  Rate  in  accordance  with  the  following
procedure.  The  holders of the  Convertible  Notes and the  Company  shall each
appoint one  registered  securities  broker,  licensed with the  Securities  and
Exchange  Commission to sell  securities to the public,  which broker shall be a
senior vice  president,  managing  director or equivalent of a major  securities
brokerage company with offices in New York, New York. Each of such brokers shall
have no less than ten (10) years experience in such field, shall be unaffiliated
with,  and their employer  securities  brokerage  company shall be  unaffiliated
with,  the holders of the  Convertible  Notes and the Company and shall not have
previously participated in any underwriting of the Company's Common Stock in any
public  offering  or  provided  any  Material  investment  banking or  corporate
advisory  services to the Company.  The holders of the Convertible Notes and the
Company shall make their appointments  promptly and, in any event, within thirty
(30) days from the date of the  Conversion  Rate  Certificate.  The two  brokers
shall meet and shall be  instructed  to render a  determination  of the adjusted
Conversion Rate to the holders of the  Convertible  Notes and the Company within
sixty  (60)  days of the date of the  Conversion  Rate  Certificate.  If the two
brokers  cannot  agree,   then  each  broker  shall  render  their   independent
determination  and the two brokers shall  simultaneously  therewith  provide the
name of a third broker  acceptable  to the two brokers  meeting the criteria set
forth above.  The third broker shall be instructed to render a determination  of
the adjusted Conversion Rate within thirty (30) days of his or her


<PAGE>



appointment.  The two closest  determinations  of the adjusted  Conversion  Rate
shall be averaged and shall constitute the adjusted  Conversion Rate. If the two
brokers cannot agree upon a third broker,  the selection of a third broker shall
be submitted to binding arbitration in New York, New York under the rules of the
American Arbitration  Association.  In the event that the difference between the
Company's calculation of the adjusted Conversion Rate and the calculation of the
adjusted  Conversion  Rate  determined by the foregoing  process is five percent
(5%) or greater then the costs and  expenses of the brokers and any  arbitration
shall be paid by and be the obligation of the Company and in the event that such
difference is less than five percent (5%) the holders of the  Convertible  Notes
(as a group) shall each pay its pro rata share of 50% of such costs and expenses
and the Company shall pay 50% of such costs and expenses.

                  (d) In case:

                  (1) the Company shall declare a dividend or other distribution
         on its Common Stock payable (i) otherwise  than  exclusively in cash or
         (ii) exclusively in cash in an amount that would require any adjustment
         pursuant to Section 2(b); or

                  (2) the Company shall authorize the granting to the holders of
         its Common Stock of rights, options, warrants or convertible securities
         to subscribe  for or purchase any shares of capital  stock of any class
         or of any other rights; or

                  (3)  of  any  reclassification  of  the  Common  Stock  of the
         Company, or of any consolidation, merger or share exchange to which the
         Company is a party and for which  approval of any  shareholders  of the
         Company is required,  or of the conveyance,  sale, transfer or lease of
         all or substantially all of the assets of the Company; or

                  (4) of the voluntary or involuntary  dissolution,  liquidation
         or winding up of the Company; or

                  (5) the  Company  or any  Subsidiary  shall  commence a tender
         offer  for all or a  portion  of the  Company's  outstanding  shares of
         Common Stock (or shall amend any such tender offer);

then the Company shall cause to be delivered to the holder of this Security,  at
least 20 days (or 10 days in any case  specified  in  clause  (1) or (2)  above)
prior  to the  applicable  record,  expiration  or  effective  date  hereinafter
specified,  a notice  stating  (x) the date on which a record is to be taken for
the  purpose  of such  dividend,  distribution,  rights,  options,  warrants  or
convertible  securities or, if a record is not to be taken, the date as of which
the  holders  of  Common  Stock  of  record  to be  entitled  to such  dividend,
distribution, rights, options,


<PAGE>



                  warrants or convertible  securities are to be determined,  (y)
                  the date on which the right to make tenders  under such tender
                  offer expires or (z) the date on which such  reclassification,
                  consolidation,  merger, share exchange, conveyance,  transfer,
                  sale,  lease,  dissolution,   liquidation  or  winding  up  is
                  expected to become  effective,  and the date as of which it is
                  expected  that  holders  of Common  Stock of  record  shall be
                  entitled  to  exchange   their  shares  of  Common  Stock  for
                  securities,  cash or  other  property  deliverable  upon  such
                  reclassification,   consolidation,   merger,  share  exchange,
                  conveyance, transfer, sale, lease, dissolution, liquidation or
                  winding  up.  Neither  the failure to give such notice nor any
                  defect  therein  shall  affect the legality or validity of the
                  proceedings  described  in  clauses  (1)  through  (5) of this
                  Section 2(d).

                                    (e) The Company  shall at all times  reserve
                  and keep available,  free from preemptive  rights,  out of its
                  authorized  but  unissued  Common  Stock,  for the  purpose of
                  effecting the  conversion of the Security,  the full number of
                  shares of Common Stock then  issuable  upon the  conversion of
                  this Security.

                                    (f) Except as provided in the next sentence,
                  the Company  will pay any and all taxes and duties that may be
                  payable  in  respect  of the  issue or  delivery  of shares of
                  Common Stock on conversion of this Security. The Company shall
                  not, however,  be required to pay any tax or duty which may be
                  payable in respect of any  transfer  involved in the issue and
                  delivery  of shares of Common  Stock in a name other than that
                  of the holder of this Security,  and no such issue or delivery
                  shall be made  unless  and until the  Person  requesting  such
                  issue has paid to the  Company  the  amount of any such tax or
                  duty, or has  established to the  satisfaction  of the Company
                  that such tax or duty has been paid.

                                    (g) The  Company  agrees  that all shares of
                  Common Stock which may be  delivered  upon  conversion  of the
                  Security,  upon such delivery,  will have been duly authorized
                  and  validly  issued and will be fully paid and  nonassessable
                  (and  shall be  issued  out of the  Company's  authorized  but
                  unissued  Common Stock) and,  except as provided in the second
                  sentence  of Section  2(f),  the  Company  will pay all taxes,
                  liens and charges with respect to the issue thereof.

                                    (h)  In  case  of any  consolidation  of the
                  Company with any other Person,  any merger of the Company into
                  another  Person or of another  Person into the Company  (other
                  than a merger  which does not result in any  reclassification,
                  conversion,  exchange or cancellation of outstanding shares of
                  Common Stock of the Company) or any conveyance, sale, transfer
                  or lease of all or  substantially  all of the  properties  and
                  assets of the Company, the Person formed by such consolidation
                  or  resulting   from  such  merger  or  which   acquires  such
                  properties  and assets,  as the case may be, shall execute and
                  deliver  to  the  holder  of  this  Security  a   supplemental
                  agreement providing that such holder has the right, during the
                  period this  Security  shall be  convertible  as  specified in
                  Section  2(a), to convert this Security only into the kind and
                  amount of securities,  cash and other property receivable upon
                  such  consolidation,  merger,  conveyance,  sale,  transfer or
                  lease (including any Common Stock

                                        9


<PAGE>



                  retainable)  by a holder  of the  number  of  shares of Common
                  Stock of the Company into which this Security  might have been
                  converted  immediately  prior to such  consolidation,  merger,
                  conveyance,  sale, transfer or lease,  assuming such holder of
                  Common Stock of the Company (i) is not a Person with which the
                  Company  consolidated,  into which the Company merged or which
                  merged  into the  Company or to which such  conveyance,  sale,
                  transfer or lease was made, as the case may be (a "Constituent
                  Person"),  or an  Affiliate of a  Constituent  Person and (ii)
                  failed to exercise its rights of  election,  if any, as to the
                  kind  or  amount  of  securities,   cash  and  other  property
                  receivable upon such consolidation,  merger, conveyance, sale,
                  transfer  or lease  (provided  that if the kind or  amount  of
                  securities,  cash and  other  property  receivable  upon  such
                  consolidation, merger, conveyance, sale, transfer, or lease is
                  not the same for each  share of  Common  Stock of the  Company
                  held  immediately   prior  to  such   consolidation,   merger,
                  conveyance,   sale,   transfer  or  lease  by  others  than  a
                  Constituent Person or an Affiliate of a Constituent Person and
                  in  respect of which such  rights of  election  shall not have
                  been exercised ("Non-electing Share"), then for the purpose of
                  this Section 2(h) the kind and amount of securities,  cash and
                  other property  receivable  upon such  consolidation,  merger,
                  conveyance,  sale,  transfer  or lease by the  holders of each
                  Non- electing  Share shall be deemed to be the kind and amount
                  so  receivable  per share by a plurality  of the  Non-electing
                  Shares).   Such  supplemental   agreement  shall  provide  for
                  adjustments which, for events subsequent to the effective date
                  of such supplemental agreement,  shall be as nearly equivalent
                  as may be practicable to the adjustments  provided for in this
                  Section 2. The above  provisions  of this  Section  2(h) shall
                  similarly   apply  to  successive   consolidations,   mergers,
                  conveyances,  sales,  transfers or leases.  In this paragraph,
                  "securities of the kind receivable"  upon such  consolidation,
                  merger,  conveyance,  transfer,  sale or lease by a holder  of
                  Common Stock means securities  that,  among other things,  are
                  registered and freely  transferable  under the Securities Act,
                  and  listed  and  approved  for  quotation  in all  securities
                  markets, in each case to the same extent as such securities so
                  receivable by a holder of Common Stock.

                                    (i)  The   Company   (i)  will   effect  all
                  registrations   with,   and  obtain  all   approvals  by,  all
                  governmental  authorities  that  may be  necessary  under  any
                  United States  Federal or state law  (including the Securities
                  Act, the Exchange Act and state  securities and Blue Sky laws)
                  for the shares of Common Stock  issuable  upon  conversion  of
                  this Security to be lawfully  issued and delivered as provided
                  herein,  and thereafter  publicly traded (if permissible under
                  the Securities Act) and qualified or listed as contemplated by
                  clause (ii) (it being understood that the Company shall not be
                  required to register the Common Stock  issuable on  conversion
                  hereof  under  the  Securities  Act,  except  pursuant  to the
                  Registration  Rights  Agreement  between  the  Company and the
                  initial  holder  of this  Security);  and (ii)  will  list the
                  shares of Common  Stock  required  to be issued and  delivered
                  upon  conversion  of  Securities,  prior to such  issuance  or
                  delivery,  on  each  national  securities  exchange  on  which
                  outstanding  Common  Stock is  listed or quoted at the time of
                  such  delivery,  or if the Common  Stock is not then listed on
                  any  securities  exchange,  to qualify  the  Common  Stock for
                  quotation  on  the  Nasdaq   National  Market  or  such  other
                  inter-dealer  quotation  system,  if any,  on which the Common
                  Stock is then quoted.

                                       10


<PAGE>



                  (i) For purposes  hereof:  (references  to Sections shall mean
Sections of this Security unless otherwise specified)

                  "Affiliate"  of any  specified  Person  means any other Person
directly or indirectly  controlling or controlled by or under direct or indirect
common control with such specified Person.  For the purposes of this definition,
"control",  when used with respect to any specified  Person,  means the power to
direct the  management  and  policies of such  Person,  directly or  indirectly,
whether  through the ownership of voting  securities,  by contract or otherwise;
and the terms  "controlling" and "controlled"  have meanings  correlative to the
foregoing.

                  "Business  Day" means any day other than a Saturday,  a Sunday
or other day which shall be in Boston,  Massachusetts or New York, New York or a
legal holiday or a day on which commercial banks in Boston, Massachusetts or New
York, New York are required or authorized to be closed.

                  "Cash  Distribution"  means the distribution by the Company to
holders of its  Common  Stock of cash,  other than any cash that is  distributed
upon a merger or  consolidation  to which  Section  2(h) applies or as part of a
distribution referred to in paragraph (4) of Section 2(b).

                  "Change of Control" is defined in Section 3(f)(2).

                  "Closing"  is  defined  in  Section  1 of  the  Note  Purchase
Agreement.

                  "Closing Price" means, with respect to the Common Stock of the
Company,  for any day,  the  reported  last sale  price per share on the  Nasdaq
National  Market,  or, if the  Common  Stock is not  admitted  to trading on the
Nasdaq  National  Market,  on the  principal  national  securities  exchange  or
inter-dealer quotation system on which the Common Stock is listed or admitted to
trading,  or if not admitted to trading on the Nasdaq National Market, or listed
or  admitted to trading on any  national  securities  exchange  or  inter-dealer
quotation  system,  the average of the closing bid and asked prices per share in
the  over-the-counter  market as furnished by any New York Stock Exchange member
firm selected from time to time by the Company for that purpose.

                  "Code"  means the Internal  Revenue  Code of 1986,  as amended
from time to time, and the rules and  regulations  promulgated  thereunder  from
time to time.

                  "Common  Stock"  means the  Common  Stock,  par value $.01 per
share,  of the Company  authorized at the date of this  instrument as originally
executed.  Subject  to the  provisions  of  Section  2(h),  shares  issuable  on
conversion or  repurchase  of this Security  shall include only shares of Common
Stock or shares of any class or  classes  of  common  stock  resulting  from any
reclassification or reclassifications thereof; provided, however, that if at

                                       11


<PAGE>



any time  there  shall be more  than one such  resulting  class,  the  shares so
issuable  on  conversion  of this  Security  shall  include  shares  of all such
classes,  and  the  shares  of  each  such  class  then  so  issuable  shall  be
substantially  in the proportion  which the total number of shares of such class
resulting from all such reclassifications bears to the total number of shares of
all such classes resulting from all such reclassifications.

                  "Convertible  Note(s)"shall  mean one or more of the Company's
9.00% Senior Convertible Notes due January 20, 2004.

                  "Conversion Price" is defined in Section 1.

                  "Conversion Rate" is defined in Section 2(a).

                  "Default"  means an  event  or  condition  the  occurrence  or
existence  of which  would,  with the  lapse of time or the  giving of notice or
both, become an Event of Default.

                  "Designated Office" is defined in the Preamble.

                  "Determination Date" means, in the case of a dividend or other
distribution, including the issuance of rights, options, warrants or convertible
securities, to the date fixed for the determination of those entitled to receive
such dividend or other distribution, and in the case of a tender offer, the last
time that tenders could have been made pursuant to such tender offer.

                  "Environmental Laws" means any and all Federal,  state, local,
and foreign statutes, laws, regulations,  ordinances,  rules, judgments, orders,
decrees,   permits,   licenses,   written  agreements  or  written  governmental
restrictions  relating to pollution and the protection of the environment or the
release of any  materials  into the  environment,  including  but not limited to
those related to hazardous substances or wastes, air emissions and discharges to
waste or public systems.

                  "ERISA" means the Employee  Retirement  Income Security Act of
1974, as amended from time to time,  and the rules and  regulations  promulgated
thereunder from time to time in effect.

                  "ERISA  Affiliate" means any trade or business (whether or not
incorporated)  that is treated as a single  employer  together  with the Company
under section 414 of the Code.

                  "Excess Purchase Payment" means the product of (A) the excess,
if any, of (i) the amount of cash plus the fair market value (as  determined  in
good faith by the Company's  Board of  Directors) of any non-cash  consideration
required to be paid with respect to one share of Common Stock  acquired or to be
acquired in a tender offer made by the Company

                                       12


<PAGE>



or any Subsidiary of the Company for all or any portion of the Common Stock over
(ii) the current  market price per share as of the last time that tenders  could
have been  made  pursuant  to such  tender  offer  and (B) the  number of shares
validly  tendered and not withdrawn as of the  Determination  Date in respect of
such tender offer.

                  "Event of Default" is defined in the preamble to Section 4.

                  "Exchange Act" shall mean the Securities Exchange Act of 1934,
as amended,  or any successor Federal statute,  and the rules and regulations of
the Securities and Exchange Commission promulgated  thereunder,  all as the same
shall be in effect from time to time.

                  "GAAP" means generally  accepted  accounting  principles as in
effect from time to time in the United States of America.

                  "Hazardous  Materials" means any and all pollutants,  toxic or
hazardous  wastes or any other  substances that might pose a hazard to health or
safety, the remediation of which may be required or the generation, manufacture,
refining, production,  processing, treatment, storage, handling, transportation,
transfer, use, disposal, release, discharge, spillage, seepage, or filtration of
which is restricted, prohibited or penalized by any applicable Environmental Law
(including, without limitation,  asbestos, urea formaldehyde foam insulation and
polychlorinated biphenyls).

                  "holder"  means,  with  respect to this  Security or any other
Convertible  Note,  the Person in whose name it is  registered  in the  register
maintained by the Company pursuant to Section 6(d).

                  "Lien" means, with respect to any Person, any mortgage,  lien,
pledge, charge, security interest or other encumbrance, or any interest or title
of any vendor,  lessor, lender or other secured party to or of such Person under
any  conditional  sale or other title  retention  agreement or Capital Lease (as
defined by GAAP),  upon or with  respect to any property or asset of such Person
(including in the case of stock, stockholder agreements, voting trust agreements
and all similar arrangements).

                 "Make-Whole Amount" is defined in Section 4(g).

                  "Material"   means  material  in  relation  to  the  business,
operations,  affairs,  financial condition,  assets, properties, or prospects of
the Company and its Subsidiaries taken as a whole.

                  "Material  Adverse Effect" means a material  adverse effect on
(a) the business,  operations,  affairs, financial condition, assets, properties
or prospects of the Company and its  Subsidiaries  taken as a whole,  or (b) the
ability of the  Company  to  perform  its  obligations  under the Note  Purchase
Agreement,  the Registration  Rights Agreement and the Convertible Notes, or (c)
the validity or enforceability of this Agreement or the Convertible Notes.

                                       13


<PAGE>



                  "Multiemployer  Plan" means any Plan that is a  "multiemployer
plan" (as such term is defined in section 4001(a)(3) of ERISA).

                  "Note Purchase Agreement" is defined in the Preamble.

                  "PBGC" means the Pension Benefit Guaranty Corporation referred
to and defined in ERISA or any successor thereto.

                  "Person"  means  an  individual,   partnership,   corporation,
limited liability company, association, trust, unincorporated organization, or a
government or agency or political subdivision thereof.

                  "Plan" means an "employee benefit plan" (as defined in section
3(3) of ERISA) that is or, within the preceding five years, has been established
or  maintained,  or to which  contributions  are or, within the  preceding  five
years,  have been  made or  required  to be made,  by the  Company  or any ERISA
Affiliate or with respect to which the Company or any ERISA  Affiliate  may have
any liability.

                  "Purchaser(s)"  JOHN HANCOCK  MUTUAL LIFE  INSURANCE  COMPANY;
JOHN HANCOCK  VARIABLE  LIFE  INSURANCE  COMPANY;  SIGNATURE  lA (CAYMAN),  LTD;
SIGNATURE 3 LIMITED; and HANCOCK MEZZANINE PARTNERS L.P.

                  "Registration  Rights Agreement" means the Registration Rights
Agreement dated as of the date hereof among the Purchasers and the Company.

                  "Repurchase Date" is defined in Section 3(a).

                  "Repurchase Price" is defined in Section 3(a).

                  "Responsible  Officer" means any Senior Financial  Officer and
any  other  senior   officer  of  the  Company  with   responsibility   for  the
administration  of the  relevant  covenants  in  this  Security  or in the  Note
Purchase Agreement.

                  "Securities  Act" shall mean the  Securities  Act of 1933,  as
amended, or any successor Federal statute,  and the rules and regulations of the
Securities and Exchange Commission promulgated thereunder, all as the same shall
be in effect from time to time.

                  "Senior Financial  Officer" means the chief financial officer,
principal accounting officer, treasurer or comptroller of the Company.

                  "Subsidiary"   means,  as  to  any  Person,  any  corporation,
association or other business  entity in which such Person or one or more of its
Subsidiaries or such Person and one or

                                       14

<PAGE>

more of its Subsidiaries owns sufficient equity or voting interests to enable it
or them (as a group)  ordinarily,  in the absence of  contingencies,  to elect a
majority of the  directors  (or Persons  performing  similar  functions) of such
entity,  and any partnership or joint venture if more than a 50% interest in the
profits  or  capital  thereof  is  owned  by such  Person  or one or more of its
Subsidiaries  or such Person and one or more of its  Subsidiaries  (unless  such
partnership  can and does  ordinarily  take major business  actions  without the
prior  approval of such Person or one or more of its  Subsidiaries).  Unless the
context  otherwise  clearly  requires,  any  reference  to a  "Subsidiary"  is a
reference to a Subsidiary of the Company.

                  "Trading  Day" means (i) if the Common  Stock is  admitted  to
trading  on  the  Nasdaq  National  Market  or any  other  system  of  automated
dissemination  of quotations of securities  prices, a day on which trades may be
effected through such system; (ii) if the Common Stock is listed or admitted for
trading  on the  New  York  Stock  Exchange  or any  other  national  securities
exchange,  a day on which such  exchange is open for  business;  or (iii) if the
Common Stock is not admitted to trading on the Nasdaq  National Market or listed
or admitted for trading on any national  securities exchange or any other system
of automated dissemination of quotation of securities prices, a day on which the
Common Stock is traded regular way in the over-the-counter  market and for which
a closing bid and a closing asked price for the Common Stock are available.

                  3. Right to Require Repurchase. (a) In the event that a Change
in Control shall occur,  then the holder of this Security  shall have the right,
at such  holder's  option,  to require the Company to  repurchase,  and upon the
exercise of such right the  Company  shall  repurchase,  this  Security,  or any
portion of the  principal  amount hereof that is equal to $1,000 or any integral
multiple  thereof,  on the date (the  "Repurchase  Date")  that is  thirty  (30)
Trading  Days after the date on which the Company  gives  notice  thereof to the
holder of this  Security,  at a purchase  price  equal to 100% of the  principal
amount  of  this  Security  to be  repurchased  plus  interest  accrued  to  the
Repurchase Date (the "Repurchase Price"):  provided,  however, that installments
of  interest  on this  Security  whose  stated  maturity  is on or  prior to the
Repurchase Date shall be payable to the holder of this Security,  or one or more
predecessor Securities, registered as such on the relevant Record Date according
to their terms. At the option of the Company,  the Repurchase  Price may be paid
in cash or subject to the fulfillment by the Company of the conditions set forth
in each of Section 5 and Section 6 and subject to the  limitations  set forth in
each of Section 5 and  Section 6, by  delivery  of shares of Common  Stock or in
common stock of any Person which  succeeds the Company up to a maximum amount of
ten percent  (10%) of the then  issued and  outstanding  Common  Stock or common
stock of such Person  following any Change in Control,  provided,  however,  the
cash plus the fair market value of such shares shall equal the Repurchase Price.
The Company  agrees to give the holder of this Security  notice of any Change in
Control,  by facsimile  transmission  confirmed in writing by overnight  courier
service, promptly and in any event within two (2) Trading Days of the occurrence
thereof.

                                       15
<PAGE>



                  (b) To exercise a repurchase  right,  the holder shall deliver
to the Company on or before the 10th Trading Day prior to the  Repurchase  Date,
together with this  Security,  written  notice of the holder's  exercise of such
right, which notice shall set forth the name of the holder, the number of shares
of Common  Stock then owned by such  holder and its  affiliates,  the  principal
amount of this  Security  to be  repurchased  (and,  if this  Security  is to be
repurchased  in  part,  the  portion  of  the  principal  amount  thereof  to be
repurchased  and the name of the person in which the  portion  thereof to remain
outstanding  after such  repurchase is to be registered) and a statement that an
election to exercise  the  repurchase  right is being made  thereby  and, in the
event  that  the  Repurchase  Price  shall  be paid in  whole  or in part by the
delivery of shares,  as provided above, the name or names (and the addresses) in
which the certificates for shares shall be issued.  Such written notice shall be
irrevocable,  except that the right of the holder to convert  this  Security (or
the  portion  hereof  with  respect  to  which  the  repurchase  right  is being
exercised) shall continue until the close of business on the Repurchase Date (or
if the  Company  elects to pay the  Repurchase  Price by  delivery  of shares as
provided  above,  until the close of business  on the  Trading  Day  immediately
preceding the first delivery of shares with respect thereto).

                  (c) In the event a  repurchase  right  shall be  exercised  in
accordance  with the terms hereof,  the Company shall pay or cause to be paid to
the holder the Repurchase Price in cash or shares,  as provided above,  together
with accrued and unpaid interest to the Repurchase Date; provided, however, that
installments of interest that mature on or prior to the Repurchase Date shall be
payable in cash,  to the holders of this  Security,  or one or more  predecessor
Securities,  registered as such at the close of business on the relevant regular
record date.

                  (d) If this Security (or portion  thereof) is surrendered  for
repurchase and is not so paid on or prior to the Repurchase  Date. the principal
amount of this Security (or such portion hereof, as the case maybe) shall, until
paid,  bear  interest  to the  extent  permitted  by  applicable  law  from  the
Repurchase Date at eleven percent (11%) per annum, and shall remain  convertible
into Common Stock until the principal of this Security (or portion  thereof,  as
the case may be) shall have been paid or duly provided for.

                  (e) If this  Security is to be  repurchased  only in part,  it
shall be  surrendered  to the Company at the  Designated  Office  (with,  if the
Company so requires,  due endorsement by, or a written instrument of transfer in
form  satisfactory  to the Company duly  executed  by, the holder  hereof or his
attorney  duly  authorized  in writing),  and the Company shall execute and make
available for delivery to the holder without service  charge,  a new Security or
Securities,  containing  identical terms and  conditions,  each in an authorized
denomination  in  aggregate  principal  amount  equal to and in exchange for the
unrepurchased portion of the principal of the Security so surrendered.

                  (f)      For purposes of this Section 3.

                  (1)  the  term  "beneficial  owner"  shall  be  determined  in
accordance with Rule 13d-3 promulgated by the Securities and Exchange Commission
pursuant to the Exchange Act; and

                                       16


<PAGE>


                  (2) a "Change in Control"  shall be deemed to have occurred at
the time, after the original issuance of this Security, of:

                  (i) the  acquisition  by any Person of  beneficial  ownership,
         directly or indirectly, through a purchase, merger or other acquisition
         transaction  or series of  transactions,  of shares of capital stock of
         the Company  entitling such Person to exercise 50% or more of the total
         voting power of all shares of capital stock of the Company  entitled to
         vote generally in the election of directors (any shares of voting stock
         of  which  such  Person  is the  beneficial  owner  that  are not  then
         outstanding  being deemed  outstanding for purposes of calculating such
         percentage)  other  than any such  acquisition  by the  Company  or any
         employee benefit plan of the Company; or

                  (ii) any  consolidation or merger of the Company with or into,
         any  other  Person,  any  merger  of  another  Person  with or into the
         Company, or any conveyance,  transfer, sale, lease or other disposition
         of all or  substantially  all of the  assets of the  Company to another
         Person (other than (a) any such  transaction  (x) which does not result
         in  any  reclassification,  conversion,  exchange  or  cancellation  of
         outstanding shares of Common Stock and (y) pursuant to which holders of
         Common Stock immediately prior to such transaction have the entitlement
         to exercise,  directly or  indirectly,  50% or more of the total voting
         power of all shares of capital stock  entitled to vote generally in the
         election of directors of the continuing or surviving Person immediately
         after such  transaction  and (b) any merger which is effected solely to
         change the  jurisdiction of incorporation of the Company and results in
         a  reclassification,  conversion or exchange of  outstanding  shares of
         Common Stock into solely shares of common stock,

                  4. Events of Default.  (a) "Event of Default",  wherever  used
herein,  means any one of the  following  events  (whatever  the reason for such
Event of  Default  and  whether  it shall be  voluntary  or  involuntary,  or be
effected by operation of law or pursuant to any judgment, decree or order of any
court or any order,  rule or regulation of any  administrative  or  governmental
body):

                  (1) (A) default in the payment of any principal or premium, if
         any, upon this Security when the same becomes due and payable,  whether
         at  maturity or at a date fixed for  prepayment  or by  declaration  or
         otherwise  or (B)  default  in the  payment of any  interest  upon this
         Security  when it becomes  due and  payable,  and  continuance  of such
         default for a period of five (5) days; or

                  (2)  default  by  the  Company  in  the   performance  of  its
         obligations  in  respect of any  conversion  of this  Security  (or any
         portion hereof) in accordance with Section 2; or

                  (3)  failure by the  Company to give any notice of a Change of
         Control required to be delivered in accordance with Section 3(a); or

                  (4) default in the  performance,  or breach,  of any  material
         covenant  or  warranty  of the  Company  herein,  in the Note  Purchase
         Agreement, or in the Registration

                                       17


<PAGE>



         Rights  Agreements  (other than a covenant or warranty a default in the
         performance or breach of which is specifically  dealt with elsewhere in
         this  Section  4(a)) and  continuance  of such  default or breach for a
         period  of 30 days  after the  earlier  to occur  of(A)  the  Company's
         obtaining  knowledge  of such  default or (B) the  Company's  receiving
         written notice specifying such default or breach and requiring it to be
         remedied  and  stating  that  such  notice  is a  "Notice  of  Default"
         hereunder; or

                  (5) any  representation  or warranty  made in writing by or on
         behalf of the  Company or by any officer of the  Company  furnished  in
         connection  with the  transactions  contemplated  hereby proves to have
         been false or incorrect in any material respect on the date as of which
         made; or

                  (6) a final  judgment  or  judgments  for the payment of money
         aggregating  in excess of $250,000 are rendered  against one or more of
         the Company and its Subsidiaries and which judgments are not, within 60
         days after entry thereof, bonded,  discharged or stayed pending appeal,
         or are not  discharged  within 60 days  after tile  expiration  of such
         stay; or

                  (7) a  default  under  all3,  bond,  debenture,  note or other
         evidence of  indebtedness  for money borrowed by the Company,  or under
         any agreement,  mortgage, indenture or instrument under which there may
         be  issued  or  by  which  there  may  be  secured  or  evidenced   any
         indebtedness for money borrowed by the Company. with a principal amount
         then outstanding in excess of $1,000,000, whether such indebtedness now
         exists or shall hereafter be created,  which default shall constitute a
         failure to pay the principal of such  indebtedness  (in whole or in any
         part  greater  than  $1,000,0003  when due and  payable  or shall  have
         resulted in such  indebtedness  (in whole or in any part  greater  than
         $1,000.0003  becoming or being  declared  due and payable  prior to the
         date on which it would otherwise have become due and payable; or

                  (8) if(i) any Plan other than a Multiemployer  Plan shall fail
to satisfy the minimum funding  standards of ERISA or the Code for any plan year
or part thereof or a waiver of such  standards or extension of any  amortization
period is sought or  granted  under  section  412 of the Code,  (ii) a notice of
intent to terminate any Plan other than a Multiemployer  Plan shall have been or
is  reasonably  expected  to be  filed  with the  PBGC or the  PBGC  shall  have
instituted  proceedings  under  ERISA  section  4042 to  terminate  or appoint a
trustee to administer any Plan other than a Multiemployer Plan or the PBGC shall
have  notified  the  Company  or any ERISA  Affiliate  that a Plan  other than a
Multiemployer  Plan may  become a  subject  of any such  proceedings,  (iii) the
aggregate  "amount of  unfunded  benefit  liabilities"  (within  the  meaning of
section  4001(a)(183 of ERISA) under all Plans other than a Multiemployer  Plan,
determined in accordance with Title IV of ERISA, shall exceed $250,000, (iv) the
Company or any ERISA Affiliate shall have incurred or is reasonably  expected to
incur any liability  pursuant to Title I or IV of ERISA or the penalty or excise
tax provisions of the Code relating to employee  benefit plans,  (v) the Company
or any  ERISA  Affiliate  withdraws  from any  Multiemployer  Plan,  or (vi) the
Company or any  Subsidiary  establishes or amends any employee  welfare  benefit
plan that  provides  post-employment  wealthier  benefits in a manner that would
increase the liability of the

                                       18
<PAGE>



                  Company or any  Subsidiary  thereunder;  and any such event or
                  events  described  in clauses (i) through  (vi) above,  either
                  individually  or together with any other such event or events,
                  could  reasonably  be  expected  to  have a  Material  Adverse
                  Effect. (As used in this Section 4(a)(8),  the terms "employee
                  benefit plan" and "employee  welfare  benefit plan" shall have
                  the respective meanings assigned to such terms in Section 3 of
                  ERISA.); or

                                    (9) if, as a result of any Change of Control
                           or any other  consolidation or merger, the holding by
                           the  Purchasers  or any  assignees  thereof  of  this
                           Security or the holding of any Common Stock or common
                           stock of any Person succeeding the Company, issued to
                           the   Purchasers  or  any  assignees   thereof  after
                           conversion of this Security  would  constitute,  with
                           respect to any Plan (other than a Multiemployer Plan)
                           a  prohibited  transaction  which  would  violate the
                           prohibitions  of section  406 of ERISA or which would
                           subject  any  "disqualified  person"  (as  defined in
                           section  4975(e)(2) of the Code) to a tax pursuant to
                           section 4975(c)(1)(A)-(D) of the Code; or

                                    (10)   the   entry   by   a   court   having
                           jurisdiction  in the premises of(A) a decree or order
                           for  relief  in   respect   of  the   Company  in  an
                           involuntary  case or proceeding  under any applicable
                           Federal    or    State    bankruptcy,     insolvency,
                           reorganization  or other  similar law or (B) a decree
                           or  order   adjudging   the  Company  a  bankrupt  or
                           insolvent,  or approving as properly filed a petition
                           seeking  reorganization,  arrangement,  adjustment or
                           composition of or in respect of the Company under any
                           applicable  Federal or State  law,  or  appointing  a
                           custodian, receiver,  liquidator,  assignee, trustee,
                           sequestrator or other similar official of the Company
                           or of  any  substantial  part  of  its  property,  or
                           ordering  the  winding  up  or   liquidation  of  its
                           affairs,  and the  continuance  of any such decree or
                           order for  relief or any such  other  decree or order
                           unstayed and in effect for a period of 60 consecutive
                           days; or

                                    (11) the  commencement  by the  Company of a
                           voluntary  case or  proceeding  under any  applicable
                           Federal    or    State    bankruptcy,     insolvency,
                           reorganization  or other  similar law or of any other
                           case or  proceeding  to be  adjudicated a bankrupt or
                           insolvent,  or the  consent  by it to the  entry of a
                           decree or order for relief in respect of the  Company
                           in  an  involuntary  case  or  proceeding  under  any
                           applicable  Federal or State bankruptcy,  insolvency,
                           reorganization   or  other  similar  law  or  to  the
                           commencement  of any bankruptcy or insolvency case or
                           proceeding  against  it,  or  the  filing  by it of a
                           petition or answer or consent seeking  reorganization
                           or similar  relief  under any  applicable  Federal or
                           State law, or the consent by it to the filing of such
                           petition   or  to  the   appointment   of  or  taking
                           possession  by  a  custodian,  receiver,  liquidator,
                           assignee,  trustee,  sequestrator  or  other  similar
                           official of the Company or of any substantial part of
                           its  property,  or the making by it of an  assignment
                           for the benefit of creditors, or not paying its debts
                           as they become due or the  admission by it in writing
                           of its  inability to pay its debts  generally as they
                           become due, or the taking of corporate  action by the
                           Company in furtherance of any such action.

                                    (b) If an Event of  Default  (other  than an
                  Event of Default  specified  in Section  4(a)(l0) or 4(a)(11))
                  occurs and is  continuing,  then in every such case the holder
                  of this  Security may declare the  principal  hereof to be due
                  and payable immediately, by a notice in

                                       19
<PAGE>



                  writing to the  Company,  and upon any such  declaration  such
                  principal  and  all  accrued   interest  hereon  shall  become
                  immediately  due  and  payable  without  presentment,  demand,
                  protest or other  notice of any kind,  all of which are hereby
                  expressly  waived,  and the Company shall  forthwith  upon any
                  such  acceleration  pay to the holder of this Security (i) the
                  entire principal of and interest accrued on this Security, and
                  (ii) in addition,  to the extent  permitted by applicable law,
                  an  amount  equal  to the Make  Whole  Amount,  as  liquidated
                  damages and not as a penalty; and, in

                  case of the occurrence of an Event of Default of the character
                  described in  subdivisions  4(a)(10) or 4(a)(11) the principal
                  of and  accrued  interest on this  Security,  ipso facto shall
                  become  immediately due and payable without any declaration or
                  other  act  of  the  holder  of  this   Security  and  without
                  presentment,  demand, protest or other notice of any kind, all
                  of which are hereby  expressly  waived,  and the Company shall
                  forthwith upon any such acceleration pay to the holder of this
                  Security (x) the entire  principal of and interest  accrued on
                  this Security and (y) in addition, if such Event of Default is
                  "Voluntary" (as hereinafter  defined), to the extent permitted
                  by applicable  law, an amount equal to the Make-Whole  Amount,
                  as liquidated damages and not as a penalty.

                           For purposes of this section 4(a),  "Voluntary" shall
                  mean  an  Event  of  Default  of the  character  described  in
                  subdivisions  4(a)(l 0) or 4(a)(11 ) which shall have been (x)
                  procured by the Company or any officer, director,  stockholder
                  or  Affiliate  of the Company or (y)  primarily  the result of
                  action or inaction by the Company or by any officer, director,
                  stockholder or Affiliate of the Company.

                                    (c) In case any one or more of the Events of
                  Default  specified  in section 4(a) shall have  occurred,  and
                  irrespective  of whether this  Security has become or has been
                  declared  immediately  due and payable under section 4(a), the
                  holder of this Security may proceed to protect and enforce its
                  rights  either by suit in equity or by action at law, or both.
                  The Company  stipulates that the remedies at law of the holder
                  of this  Security  in the event of any  Default or  threatened
                  Default by the  Company in the  performance  of or  compliance
                  width any  covenant or agreement  in this  Security,  the Note
                  Purchase  Agreement or the  Registration  Rights Agreement are
                  not and will not be adequate and that,  to the fullest  extent
                  permitted by law, such terms may be specifically enforced by a
                  decree for the  specific  performance  thereof,  whether by an
                  injunction against a violation thereof or otherwise.

                                    (d) No remedy  conferred  in this  Security,
                  the  Note  Purchase  Agreement  or  the  Registration   Rights
                  Agreement is intended to be exclusive of any other remedy, and
                  each and every such remedy shall be cumulative and shall be in
                  addition to every other remedy given  hereunder or  thereunder
                  or now or hereafter existing at law or in equity or by statute
                  or otherwise.

                                    (e) No course of dealing between the Company
                  and any of its  Subsidiaries,  on the one hand, and the holder
                  of this Security,  on the other hand, and no delay by any such
                  holder in  exercising  any rights  hereunder or under the Note
                  Purchase Agreement or the Registration  Rights Agreement shall
                  operate as a waiver of any rights of such holder.

                                       20
<PAGE>



                  (f) In case any one or more of the Events of Default specified
in section 4(a) shall have occurred, all amounts to be applied to the prepayment
or payment of this Security  shall be applied,  after the payment of all related
costs and expenses incurred by the holder of this Security  (including,  without
limitation,  compensation  to any and all  trustees,  liquidators,  receivers or
similar officials and reasonable fees, expenses and disbursements of counsel) in
such order of priority as is determined by the holder of this Security.

                  (g) The term "Make-Whole  Amount" means,  with respect to this
Security,  an amount equal to the excess, if any, of the Discounted Value of the
Remaining  Scheduled  Payments  with  respect  to the Called  Principal  of this
Security over the amount of such Called Principal,  provided that the Make-Whole
Amount may in no event be less than zero.  For the purposes of  determining  the
Make-Whole Amount, the following terms have the following meanings:

                  "Called  Principal" means, with respect to this Security,  the
         principal  of this  Security  that  has  become  or is  declared  to be
         immediately due and payable pursuant to Section 4(b).

                  "Discounted Value" means, with respect to the Called Principal
         of this  Security,  the amount  obtained by  discounting  all Remaining
         Scheduled  Payments  with respect to such Called  Principal  from their
         respective  scheduled due dates to the Settlement  Date with respect to
         such Called Principal,  in accordance with accepted  financial practice
         and at a discount factor (applied on the same periodic basis as that on
         which interest on this Security is payable)  equal to the  Reinvestment
         Yield with respect to such Called Principal.

                  "Reinvestment   Yield"  means,  with  respect  to  the  Called
         Principal of this Security, 150 basis points over the yield to maturity
         implied by (i) the  yields  reported,  as of 10:00 A.M.  (New York City
         time) on the second  Business Day  preceding the  Settlement  Date with
         respect to such Called Principal,  on the display  designated as "PX-I"
         of the Bloomberg  Financial Markets Services Screen for actively traded
         U.S.  Treasury  securities  having a  maturity  equal to the  Remaining
         Average Life of such Called  Principal as of such  Settlement  Date, or
         (ii) if such  yields  are not  reported  as of such time or the  yields
         reported as of such time are not  ascertainable,  the Treasury Constant
         Maturity  Series  Yields  reported,  for the  latest day for which such
         yields have been so reported as of the second  Business  Day  preceding
         the Settlement Date with respect to such Called  Principal,  in Federal
         Reserve  Statistical  Release H.15 (519) (or any  comparable  successor
         publication)  for actively  traded U.S.  Treasury  securities  having a
         constant  maturity  equal to the Remaining  Average Life of such Called
         Principal  as of such  Settlement  Date.  Such  implied  yield  will be
         determined,   if  necessary,  by  (a)  converting  U.S.  Treasury  bill
         quotations  to  bond-equivalent  yields  in  accordance  with  accepted
         financial  practice  and (b)  interpolating  linearly  between  (1) the
         actively traded U.S. Treasury security with the duration closest to and
         greater than the  Remaining  Average  Life and (2) the actively  traded
         U.S.  Treasury  security with the duration closest to and less than the
         Remaining Average Life.

                                       21
<PAGE>



                  "Remaining  Average  Life"  means,  with respect to any Called
         Principal,  the number of years (calculated to the nearest  one-twelfth
         year) obtained by dividing (i) such Called  Principal into (ii) the sum
         of the products obtained by multiplying (a) the principal  component of
         each Remaining  Scheduled Payment with respect to such Called Principal
         by (b) the number of years (calculated to the nearest one-twelfth year)
         that will  elapse  between  the  Settlement  Date with  respect to such
         Called Principal and the scheduled due date of such Remaining Scheduled
         Payment.

                  "Remaining  Scheduled  Payment"  means,  with  respect  to the
         Called  Principal  of  this  Security,  all  payments  of  such  Called
         Principal and interest  thereon that would be due after the  Settlement
         Date with respect to such Called Principal if no payment of such Called
         Principal  were made prior to its scheduled due date,  provided that if
         such Settlement  Date is not a date on which interest  payments are due
         to be made  under the terms of this  Security,  then the  amount of the
         next  succeeding  scheduled  interest  payment  will be  reduced by the
         amount of interest accrued to such Settlement Date.

                  "Settlement  Date" means, with respect to the Called Principal
         of this Security, the date on which such Called Principal or has become
         or is declared to be  immediately  due and payable  pursuant to Section
         4(b).

                  5.  Consolidation.  Merger,  Etc.  (a) The  Company  shall not
consolidate  with or merge into any other  Person or,  directly  or  indirectly,
convey,  transfer,  sell or lease all or substantially all of its properties and
assets to any Person, and the Company shall not permit any Person to consolidate
with or merge into the Company or,  directly or  indirectly,  convey,  transfer,
sell or lease  all or  substantially  all of its  properties  and  assets to the
Company, unless:

                  (1) in case the Company shall  consolidate  with or merge into
         another Person or convey,  transfer, sell or lease all or substantially
         all of its  properties  and assets to any Person,  the Person formed by
         such  consolidation  or into which the  Company is merged or the Person
         which acquires by conveyance, transfer or sale, or which leases, all or
         substantially  all the  properties and assets of the Company shall be a
         corporation,  limited liability company, partnership or trust, shall be
         organized and validly  existing  under the laws of the United States of
         America,  any State  thereof  or the  District  of  Columbia  and shall
         expressly assume,  by an agreement  supplemental  hereto,  executed and
         delivered to the holder of this  Security in form  satisfactory  to the
         holder,  the due and punctual  payment of the principal of(and premium,
         if any) and interest on this Security and the performance or observance
         of every  covenant  of this  Security  on the part of the Company to be
         performed or observed,  including the conversion rights provided herein
         (which shall thereafter relate to common stock of such successor,  on a
         basis reasonably  designed to preserve the economic value to the holder
         of this Security of such conversion rights);

                  (2)  immediately  after giving effect to such  transaction and
         treating any indebtedness which becomes an obligation of the Company or
         a Subsidiary of the Company as a result of such  transaction  as having
         been  incurred by the Company or such  Subsidiary of the Company at the
         time of such transaction, no Event of Default, and no

                                       22

<PAGE>

         event  which,  after  notice or lapse of time or both,  would become an
Event of Default, shall have happened and be continuing;

                  (3) the Company has  delivered to the holder of this  Security
         an  officers'  certificate  stating  that such  consolidation,  merger,
         conveyance, transfer, sale or lease and, if a supplemental agreement is
         required  in  connection  with  such  transaction,   such  supplemental
         agreement,  comply with this Section and that all conditions  precedent
         herein  provided for relating to such  transaction  have been  complied
         with; and

                  (4) counsel for the  Company  has  delivered  to the holder of
         this  Security  an  opinion  of  such  counsel  with  respect  to  such
         consolidation,  merger,  conveyance,  transfer, sale or lease, and if a
         supplemental agreement is required in connection with such transaction,
         such  supplemental  agreement,  which  opinion  shall  be,  in form and
         substance, reasonably acceptable to such holder and its counsel.

                  (b) Upon any  consolidation  of the Company with, or merger of
the Company into, any other Person or any conveyance, transfer, sale or lease of
all  or  substantially  all of the  properties  and  assets  of the  Company  in
accordance with Section 5(a), the successor Person formed by such  consolidation
or into which the Company is merged or to which such conveyance,  transfer, sale
or lease is made shall  succeed to, and be  substituted  for,  and may  exercise
every right and power of, the Company  under this  Security with the same effect
as if  such  successor  Person  had  been  named  as  the  Company  herein,  and
thereafter,  except  in the case of a lease,  the  predecessor  Person  shall be
relieved o fall obligations and covenants under this Security.

                  6. Payment in Stock.  (a) The Company may elect to pay some or
all of the  Repurchase  Price by delivery of shares of Common Stock or shares of
common stock in any Person  succeeding the Company,  if and only if, each of the
following  conditions shall be satisfied  (without limiting any other conditions
contained herein):

                  (1) Any such payment shall be made in five equal installments,
on each of the five  consecutive  Trading Days ending on and including the third
Trading Day immediately preceding the date when any cash payment would otherwise
be due, and the shares of Common Stock or common stock of any Person  succeeding
the Company  deliverable in payment of each such  installment  shall have a fair
market  value as of the  date of such  installment  of not less  than 20% of the
amount of such payment due  hereunder  which is payable in shares of stock.  For
purposes  of this  Section 6, the fair  market  value of shares of Common  Stock
shall be equal to 95% of the Closing Price for the immediately preceding Trading
Day;

                  (2) In the event any shares of Common Stock or common stock of
any  Person  succeeding  the  Company  to be issued in respect of any amount due
hereunder  require  registration  under any Federal  securities  law before such
shares  may be  freely  transferrable  without  being  subject  to any  transfer
restrictions under the Securities Act of 1933 upon

                                       23

<PAGE>

issuance,  such  registration  shall have been  completed  and shall have become
effective prior to the date of the first such installment;

                  (3) In the event any shares of Common Stock or common stock of
any  Person  succeeding  the  Company  to be issued in respect of any amount due
hereunder require  registration  with or approval of any governmental  authority
under any State law or any other  Federal  law before such shares may be validly
issued or delivered upon issuance or transferred freely, such registration shall
have been  completed or have become  effective and such approval shall have been
obtained, in each case, prior to the date of the first such installment;

                  (4) The shares of Common  Stock or common  stock of any Person
succeeding the Company deliverable in payment of such amount due hereunder shall
have been approved for quotation in the Nasdaq National Market immediately prior
to the date of the  first  such  installment  or,  if at the time its  shares of
Common Stock or shares of common stock of any Person  succeeding the Company are
listed or admitted for trading on any national securities  exchange,  the shares
of  Common  Stock or common  stock in any  Person  succeeding  the  Company  and
deliverable shall have been so listed or admitted for trading.

                  (5) All shares of Common  Stock or common  stock of any Person
succeeding  the  Company  deliverable  in payment of such  amount due  hereunder
shall, upon issue, be duly and validly issued and fully paid and  non-assessable
and free of any preemptive rights;

                  (6) In respect of each such payment  date,  the Company  shall
have given the holder of this Security not less than 10 nor more than 15 Trading
Days' notice of its  election to effect  payment in respect of such payment date
by  delivery of shares of Common  Stock;  provided  that any such  notice  shall
accompany the Company's notice of a Change of Control relating thereto; and

                  (7) The  Company  shall  deliver,  or cause to be  delivered a
certificate  from the Person  succeeding  the Company which  states,  that after
giving effect to any Change of Control that the holding by the Purchasers or any
assignees thereof of this Security, or the holding of any Common Stock or common
stock of any Person  succeeding  the Company  after  conversion of this Security
would  not  constitute  a  prohibited   transaction   which  would  violate  the
prohibition  of section  406 of ERISA or which would  subject any  "disqualified
person"  (as  defined in section  4975(e)(2)  of the Code) to a tax  pursuant to
section 4975 (c)(1)(A)-(D) of the Code.

                  If all of the  conditions  set forth in this  Section 6(a) are
not satisfied in accordance with the terms hereof, any such amount due hereunder
shall be paid by the Company only in cash.

                  (b) Any issuance of shares of Common Stock or shares of common
stock of any Person  succeeding  the Company in respect of any  installment  due
hereunder  pursuant  to this  Section 6 shall be  deemed  to have been  effected
immediately prior to the close of

                                       24

<PAGE>

                  business on the date of delivery of such  installment  and the
                  person or persons in whose  name or names any  certificate  or
                  certificates for shares of Common Stock shall be issuable upon
                  such delivery  shall be deemed to have become on such date the
                  holder or holders of record of the shares represented thereby;
                  provided,  however,  that in case any installment shall be due
                  on a date when the stock  transfer  books of the Company shall
                  be  closed,  the  person or persons in whose name or names the
                  certificate or  certificates  for such shares are to be issued
                  shall be deemed to have  become the  record  holder or holders
                  thereof  for all  purposes  at the  opening of business on the
                  next  succeeding  day on which such stock  transfer  books are
                  open. No payment or adjustment  shall be made for dividends or
                  distributions  on any Common  Stock  issued  pursuant  to this
                  Section 6 declared prior to the relevant delivery date; and

                                    (c)   Any    issuance    and   delivery   of
                  certificates  for  shares of common  stock or shares of common
                  stock of any Person  succeeding  the Company  pursuant to this
                  Section 6 shall be made  without  charge to the holder of this
                  Security  for  such  certificates  or for  any  tax or duty in
                  respect of the  issuance or delivery of such  certificates  or
                  the securities represented thereby.

                                    7. Other.  (a) No provision of this Security
shall alter or impair the  obligation  of the  Company,  which is  absolute  and
unconditional,  to pay the principal of,  premium,  if any, and interest on this
Security  in cash at the times,  places and rate,  and in the coin or  currency,
herein prescribed or to convert this Security as herein provided.

                                    (b) The  Company  will give  prompt  written
                  notice to the holder of Security of any change in the location
                  of the Designated Office.

                                    (c)  The   transfer  of  this   Security  is
                  registrable  on the  Security  Register  of the  Company  upon
                  surrender of this Security for registration of transfer at the
                  Designated  Office,  duly  endorsed  by, or  accompanied  by a
                  written  instrument  of transfer in form  satisfactory  to the
                  Company duly  executed  by, the holder  hereof or his attorney
                  duly  authorized  in writing,  and  thereupon  one or more new
                  Securities,  of  authorized  denominations  and for  the  same
                  aggregate  principal amount,  will be issued to the designated
                  transferee or  transferees.  Such Securities are issuable only
                  in registered form without coupons in  denominations of $1,000
                  and any integral multiple thereof.  No service charge shall be
                  made for any such  registration  of transfer,  but the Company
                  may require  payment of a sum sufficient to recover any tax or
                  other  governmental  charge  payable in connection  therewith.
                  Prior to due presentation of this Security for registration of
                  transfer,  the  Company and any agent of the Company may treat
                  the Person in whose name this  Security is  registered  as the
                  owner thereof for all  purposes,  whether or not this Security
                  be  overdue,  and neither the Company nor any such agent shall
                  be affected by notice to the contrary.

                                    (d) The Company shall keep at the Designated
                  Office a register for the  registration  and  registration  of
                  transfers of Convertible  Notes.  The name and address of each
                  holder of one or more Convertible Notes, each transfer thereof
                  and the name and  address  of each  transferee  of one or more
                  Convertible Notes shall be registered in such register.  Prior
                  to due presentment for registration of transfer, the Person in
                  whose name any Convertible Note

                                       25
<PAGE>

shall be registered  shall be deemed and treated as the owner and holder thereof
for all purposes hereof,  and the Company shall not be affected by any notice or
knowledge to the contrary. The Company shall give to any holder of a Convertible
Note  promptly upon request  therefor,  a complete and correct copy of the names
and addresses of all registered holders of Convertible Notes.

                  (e) Upon surrender of any  Convertible  Note at the Designated
Office for  registration of transfer or exchange (and in the case of a surrender
for  registration  of  transfer,  duly  endorsed  or  accompanied  by a  written
instrument  of  transfer  duly  executed  by  the  registered   holder  of  such
Convertible  Note or his attorney duly  authorized in writing and accompanied by
the address  for notices of each  transferee  of such  Convertible  Note or part
thereof),  the Company  shall  execute and  deliver,  at the  Company's  expense
(except as provided below),  one or more new Convertible  Notes (as requested by
the holder thereof) in exchange therefor, in an aggregate principal amount equal
to the unpaid  principal amount of the surrendered  Convertible  Note. Each such
new Convertible  Note shall be payable to such Person as such holder may request
and  shall  be  substantially  in the  form  of this  Security.  Each  such  new
Convertible  Note  shall  be  dated  and  bear  interest  from the date to which
interest shall have been paid on the surrendered  Convertible  Note or dated the
date of the  surrendered  Convertible  Note if no interest  shall have been paid
thereon.  The Company may require payment of a sum sufficient to cover any stamp
tax or  governmental  charge  imposed in respect  of any such  transfer  of this
Security.  Convertible  Notes shall not be transferred in  denominations of less
than $100,000, provided that if necessary to enable the registration of transfer
by a holder of its entire holding of Convertible Notes, one Convertible Note may
be in a denomination of less than $100,000. Any transferee, by its acceptance of
a Convertible Note registered in its name (or the name of its nominee), shall be
deemed  to have  made the  representation  set  forth in  Section  3 of the Note
Purchase Agreement.

                  (f)  Upon  receipt  by  the  Company  of  evidence  reasonably
satisfactory  to it of the  ownership  of and the loss,  theft,  destruction  or
mutilation of this Security  (which evidence shall be notice from such holder of
such ownership and such loss, theft, destruction or mutilation), and

                  (i) in the case of loss,  theft or  destruction,  of indemnity
         reasonably  satisfactory  to it  (provided  that if the  holder of this
         Security  is, or is a  nominee  for,  an  original  holder  or  another
         institutional  investor  holder of this  Security,  such  Person's  own
         unsecured  agreement of indemnity shall be deemed to be  satisfactory),
         or

                  (ii)  in  the  case  of   mutilation,   upon   surrender   and
         cancellation thereof,

the Company at its own expense shall execute and deliver, in lieu thereof, a new
Convertible  Note,  dated and bearing  interest from the date to which  interest
shall have been paid on such lost,  stolen,  destroyed or mutilated  Convertible
Note or dated the date of such lost, stolen,  destroyed or mutilated Convertible
Note if no interest shall have been paid thereon.

                                       26
<PAGE>


                  (g)  This  Security  shall be  governed  by and  construed  in
accordance with the laws of the State of New York, United States of America.

                  (h) So long as you or your  nominee  shall be  holder  of this
Security and  notwithstanding  anything in this  Security to the  contrary,  the
Company  will pay all sums  becoming due  hereunder  for  principal,  Make-Whole
Amount, if any, and interest by the method and at the address specified for such
purpose below your name in Schedule I of the Note Purchase Agreement, or by such
other method provided in the Preamble or at such other address as you shall have
from time to time specified to the Company in writing for such purpose,  without
the  presentation  or surrender of this Security,  or the making of any notation
hereon,  except that upon written request of the Company made  concurrently with
or  reasonably  promptly  after  payment  in full of this  Security,  you  shall
surrender  this Security for  cancellation,  reasonably  promptly after any such
request to the  Company  at its  principal  executive  office or at the place of
payment most  recently  designated  by the  Company.  Prior to any sale or other
disposition of this Security you will, at your election,  either endorse thereon
the amount of  principal  paid  thereon and the last date to which  interest has
been paid  thereon or surrender  this  Security to the Company in exchange for a
new Convertible  Note pursuant to the terms hereof.  The Company will afford the
benefits of this  Section to any  institutional  investor  that is the direct or
indirect transferee of this Security.

                     [END OF PAGE - SIGNATURE PAGE FOLLOWS]


                                       27

<PAGE>



                  Signature  Page of 9.00% Senior  Convertible  Note due January
20, 2004

                  1N WITNESS WHEREOF, the Company has caused this Security to be
         duly executed under its corporate seal.

         Dated: January 20, 1999
                                                            CELGENE CORPORATION

                                                               Name:
                                                               Title:
                    Attest:




<PAGE>



                                        ELECTION OF HOLDER TO REQUIRE REPURCHASE

                         1.  Pursuant  to  Section  3(a) of this  Security,  the
               undersigned  hereby  elects  to  have  all or a  portion  of this
               Security repurchased by the Company.

                         2. The  undersigned  hereby  directs the Company to pay
       [choose  one] (a) it or (b) Name: ; address:  ; Social  Security or Other
       Taxpayer  Identification  Number, if any: , an amount in cash or equal to
       100% of the principal amount to be repurchased (as set forth below), plus
       interest accrued to the Repurchase Date, as provided herein.

                                                     Dated:


                                   Signature

        Number of shares of Common Stock owned by the holder and its affiliates:

        Principal amount to be repurchased (an integral multiple of $1,000):

        Remaining  principal  amount  following such  repurchase  (not less than
        $1,000):

        NOTICE:  The signature to the foregoing  Election must correspond to the
        name as  written  upon the face of this  Security  in every  particular,
        without alteration or any change whatsoever.


<PAGE>



                                CONVERSION NOTICE

                  The  undersigned  holder of this Security  hereby  irrevocably
exercises the option to convert this  Security,  or any portion of the principal
amount hereof (which is an integral multiple of $1,000) below  designated,  into
shares  of Common  Stock  (subject  to the  limitation  set forth in the  second
paragraph of Section 2(a) of the Security) in accordance  with the terms of this
Security, and directs that such shares, together with a check in payment for any
fractional share and any Security  representing any unconverted principal amount
hereof, be delivered to and be registered in the name of the undersigned  unless
a  different  name has been  indicated  below.  If  shares  of  Common  Stock or
Securities  are  to be  registered  in the  name  of a  Person  other  than  the
undersigned,  the  undersigned  will pay all transfer taxes payable with respect
thereto.  Any  amount  required  to be paid by the  undersigned  on  account  of
interest accompanies this Security.

Dated:
                                    Signature

Number of shares of Common Stock owned by the holder and its affiliates:

If  shares  or  Securities  are to be  registered  in If only a  portion  of the
Securities  is to be the name of a person  other  than  the  holder,  converted,
please indicate: please print such person's name and address:

                               1.       Principal amount to be converted:

                                               $
           Name

                               2.       Principal amount and denomination
                                        of Security representing unconverted
                                        principal amount to be issued:

         Address

                                  Amount: $

                                  Denominations: $
                                  (any integral multiple of $1,000)

Social Security or other Taxpayer
Identification Number, if any



                                                                   EXHIBIT 10.24

                          REGISTRATION RIGHTS AGREEMENT

     REGISTRATION RIGHTS AGREEMENT, dated as of January 20, 1999, by and between
Celgene Corporation,  a Delaware  corporation (the "Company"),  and John Hancock
Mutual Life Insurance  Company,  John Hancock  Variable Life Insurance  Company,
Signature lA (Cayman) Ltd.,  Signature 3 Limited and Hancock Mezzanine  Partners
L.P. (collectively,  the "Purchasers" and singly, each "Purchaser") entered into
in  connection  with the  issuance  of a  Convertible  Note due January 20, 2004
convertible  into  shares of Common  Stock,  par value  $.01 per share  ("Common
Stock") of the Company.

     1. Certain Definitions.

     For purposes of this  Registration  Rights  Agreement,  the following terms
shall have the following respective meanings:

     (a) "Commission" shall mean the Securities and Exchange Commission,  or any
other  federal  agency  at  the  time  administering  the  Exchange  Act  or the
Securities Act, whichever is the relevant statute for the particular purpose.

     (b) Convertible Note" shall mean the Convertible Note due January 20, 2004,
of the Company to be issued and sold to the Purchaser,  and any Convertible Note
issued in exchange therefor or in lieu thereof.

     (c) "Effective  Time" shall mean the date on which the Commission  declares
the Shelf Registration  effective or on which the Shelf  Registration  otherwise
becomes effective.

     (d) "Exchange Act" shall mean the  Securities  Exchange Act of 1934, or any
successor thereto and the rules and regulations promulgated  thereunder,  as the
same shall be amended from time to time.

     (e)  "Issue  Date"  shall  mean  the date on  which a  Convertible  Note is
initially issued.

     (f) The term "person" shall mean a corporation,  association,  partnership,
organization,  business, individual, government or political subdivision thereof
or governmental agency.

     (g)  "Registration  Expenses"  shall have the meaning  assigned  thereto in
Section 4 hereof.

     (h)  "Securities  Act"  shall  mean  the  Securities  Act of  1933,  or any
successor thereto and the rules and regulations promulgated  thereunder,  as the
same shall be amended from time to time.

<PAGE>


     (i) "Shares" means the shares of Common Stock issuable upon exercise of the
Convertible Note.

     (j) "Shelf Registration" shall have the meaning assigned thereto in Section
2 hereof.

     In addition,  capitalized  terms not defined  herein shall have the meaning
ascribed in the Convertible Note.

     2. Shelf Registration of Shares.

     (a) Not later than  January  20,  2000,  the  Company  shall file under the
Securities Act a "shelf"  registration  statement providing for the registration
of, and the sale on a  continuous  or delayed  basis by the  Purchasers  of, all
shares issuable upon conversion of the Convertible  Notes,  pursuant to Rule 415
under the  Securities  Act  and/or any  similar  rule that may be adopted by the
Commission  (the  "Shelf  Registration").  The  Company  agrees  to use its best
efforts to cause the Shelf  Registration  to become or be declared  effective no
later than 45  calendar  days after the  filing  thereof  and to keep such Shelf
Registration continuously effective for a period ending on the earliest to occur
of (i) the  second  anniversary  of the Issue  Date,  (ii)  notification  to the
Company by each Purchaser that it has sold all Shares  issuable upon  conversion
of the  Convertible  Notes so owned by it, or (iii) such time as the  Purchasers
may sell all of such shares  pursuant to Rule 144(k) under the  Securities  Act.
The Company  further agrees,  if necessary,  to supplement or make amendments to
the Shelf  Registration,  if required by the rules,  regulations or instructions
applicable  to  the  registration  form  used  by the  Company  for  such  Shelf
Registration  or by the Securities Act or rules and  regulations  thereunder for
shelf  registration,  and the Company agrees to furnish to each Purchaser copies
of any such  supplement  or amendment  prior to its being used and/or filed with
the Commission,  and will not file any such supplement or amendment to which any
Purchaser reasonably objects.

     (b) Notwithstanding the foregoing, following the effectiveness of the Shelf
Registration,  the Company many, at any time,  suspend the effectiveness of such
Shelf Registration for up to 60 days, as appropriate (a "Suspension Period"), by
giving notice to each  Purchaser,  if the Company shall have determined that the
Company may be required to disclose any  material  corporate  development  which
disclosure  may  jeopardize a material  transaction or otherwise have a material
adverse effect on the Company. The Company will use its best efforts to minimize
the length of any Suspension Period. Notwithstanding the foregoing, no more than
one  Suspension  Period may occur within any 180 day period,  and no  Suspension
Period  shall be  effective  at any time the  Company  or any  affiliate  of the
Company is publicly  selling  shares of the capital stock of the Company  (other
than  pursuant  to a  registration  statement  on the  Securities  and  Exchange
Commission  Form  S-8).  The  period  of any  such  suspension  of  registration
statement  shall be added to the period of time the  Company  agrees to keep the
Shelf Registration  effective as provided in Section 2(a). Each Purchaser agrees
that, upon receipt of any notice from the Company of a Suspension  Period,  such
Purchaser shall forthwith discontinue disposition of shares covered by the Shelf
Registration  until such Purchaser (i) is advised in writing by the Company that
the use of the



                                       2
<PAGE>



applicable prospectus may be resumed, (ii) has received copies of a supplemental
or amended  prospectus,  if  applicable,  and (iii) has  received  copies of any
additional  or  supplemental  filings  which are  incorporation  or deemed to be
incorporated by reference in such prospectus.

     3. Registration Procedures.

     (a) In connection  with any  obligation of the Company to register  Shares,
the Company shall use its best efforts to effect or cause such  registration  to
permit the sale of the Shares by the Purchasers in accordance  with the intended
method  or  methods  of  distribution   thereof   described  in  the  applicable
registration statement.  In connection therewith,  the Company shall, within the
time specified in Section 2 above:

     (i) prepare and file with the  Commission a  registration  statement on any
form which may be utilized by the Company and which shall permit the disposition
of the Shares in  accordance  with the intended  method or methods  thereof,  as
specified in writing by each Purchaser;

     (ii) comply with the  provisions of the  Securities Act with respect to the
disposition  of all of the Shares  covered  by such  registration  statement  in
accordance with the intended  methods of disposition by each Purchaser set forth
in such registration statements;

     (iii) provide (A) each  Purchaser,  (B) the  underwriters  (which term, for
purposes of these  Registration  Rights,  shall include a person deemed to be an
underwriter  within the meaning of Section 2(11) of the Securities Act), if any,
thereof,  (C) the sales or placement  agent, if any,  therefor,  (D) counsel for
such  underwriters or agent,  and (E) counsel for the Purchasers the opportunity
to  participate  in  the  preparation  of  such  registration  statement,   each
prospectus included therein or filed with the Commission,  and each amendment or
supplement thereto;

     (iv) for a  reasonable  period  prior to the  filing  of such  registration
statement,  and  throughout  the  period  specified  in  Section 2 hereof,  make
available for inspection by the parties  referred to in Section  3(a)(iii) above
who shall certify to the Company that they have a current  intention to sell the
Shares  pursuant  to  the  registration   statement  such  financial  and  other
information  and books  and  records  of the  Company,  and cause the  officers,
employees,  counsel and independent  certified public accountants of the Company
to respond to such inquiries,  as shall be reasonably necessary, in the judgment
of the respective  counsel referred to in such Section,  to conduct a reasonable
investigation  within the meaning of Section 11 of the Securities Act; provided,
however,  that each such party shall be required to maintain in  confidence  and
not to disclose to any other person any  information or records  provided by the
Company and clearly marked or otherwise adequately  identified by the Company as
being confidential  until such time as (A) such information  becomes a matter of
public record (whether by virtue of its inclusion in



                                       3
<PAGE>


such registration statement or otherwise),  or (B) such person shall be required
so to disclose such  information  pursuant to the subpoena or order of any court
or other governmental agency or body having jurisdiction over the matter or over
such party  (subject  to the  requirements  of such  order,  and only after such
person  shall  have  given  the  Company  prompt  prior  written  notice of such
requirement),  or (C)  such  information  is  required  to be set  forth in such
registration  statement or the prospectus included therein or in an amendment to
such registration  statement or an amendment or supplement to such prospectus in
order that such registration statement,  prospectus, amendment or supplement, as
the case may be, does not contain an untrue statement of a material fact or omit
to state therein a material  fact required to be stated  therein or necessary to
make the statements therein not misleading;

     (v) promptly notify each Purchaser,  the sales or placement  agent, if any,
therefor and the  managing  underwriter  or  underwriters,  if any,  thereof and
confirm  such advice in writing,  (A) when such  registration  statement  or the
prospectus  included  therein  or any  prospectus  amendment  or  supplement  or
post-effective  amendment has been filed, and, with respect to such registration
statement or any post-effective  amendment,  when the same has become effective,
(B) of any  comments  by the  Commission  and  by  the  Blue  Sky or  securities
commissioner  or regulator  of any state with respect  thereto or any request by
the Commission for amendments or supplements to such  registration  statement or
prospectus or for additional information,  (C) of the issuance by the Commission
of any stop order suspending the effectiveness of such registration statement or
the initiation or overt threatening of any proceedings for that purpose,  (D) if
at any time the  representations  and warranties of the Company  contemplated by
Section 5 hereof cease to be true and correct in all material  respects,  (E) of
the receipt by the Company of any notification with respect to the suspension of
the  qualification  of the Shares for sale in any jurisdiction or the initiation
or overt threatening of any proceeding for such purpose, or (F) at any time when
a  prospectus  is required to be  delivered  under the  Securities  Act, if such
registration  statement,  prospectus,  prospectus  amendment  or  supplement  or
post-effective  amendment,  or any document  incorporated by reference in any of
the foregoing, contains an untrue statement of a material fact or omits to state
any  material  fact  required  to be stated  therein  or  necessary  to make the
statements therein not misleading in light of the circumstances then existing;

     (vi) use its best efforts to obtain the withdrawal of any order  suspending
the effectiveness of such registration statement or any post-effective amendment
thereto at the earliest practicable date;

     (vii)  if  requested  by any  managing  underwriter  or  underwriters,  any
placement or sales agent or any Purchaser,  promptly incorporate in a prospectus
supplement or  post-effective  amendment such  information as is required by the
applicable   rules  and   regulations  of  the  Commission  that  such  managing
underwriter  or  underwriters,  such agent or such  Purchaser  specify should be
included therein


                                       4
<PAGE>


relating to the terms of the sale of such Shares, including, without limitation,
information with respect to the number of Shares being sold by such Purchaser or
agent or to any underwriters,  the name and description of such Purchaser, agent
or underwriter,  the offering price of such Shares and any discount,  commission
or other compensation  payable in respect thereof, the purchase price being paid
therefor  by such  underwriters  and  with  respect  to any  other  terms of the
offering  of the  Shares  to be sold  by  such  Purchaser  or  agent  or to such
underwriters;  and make all required  filings of such  prospectus  supplement or
post-effective  amendment  promptly  after  notification  of the  matters  to be
incorporated in such prospectus supplement or post-effective amendment;

     (viii) furnish to each  Purchaser,  each placement or sales agent,  if any,
therefor, each underwriter,  if any, thereof and the respective counsel referred
to in Section  3(a)(iii) a copy of such  registration  statement  in the form in
which it became effective,  each such amendment and supplement  thereto (in each
case  including  all exhibits  thereto and documents  incorporated  by reference
therein)  and such number of copies of such  registration  statement  (excluding
exhibits  thereto  and  documents   incorporated  by  reference  therein  unless
specifically so requested by any Purchaser,  agent or  underwriter,  as the case
may be) and of the prospectus included in such registration statement (including
each preliminary prospectus and any summary prospectus),  in conformity with the
requirements of the Securities Act, and such other documents,  as any Purchaser,
agent,  if any,  and  underwriter,  if any, may  reasonably  request in order to
facilitate the offering and  disposition of the Shares owned by such  Purchaser,
offered or sold by such agent or underwritten by such  underwriter and to permit
such  Purchaser,  agent and  underwriter  to  satisfy  the  prospectus  delivery
requirements  of the Securities  Act; and the Company hereby consents to the use
of such prospectus  (including such preliminary and summary  prospectus) and any
amendment  or  supplement  thereto  by any  Purchaser  and by any such agent and
underwriter,  in each case in the form most  recently  provided to such party by
the Company,  in connection  with the offering and sale of the Shares covered by
the  prospectus  (including  such  preliminary  and summary  prospectus)  or any
supplement or amendment thereto;

     (ix) use its best  efforts  to (A)  register  or  qualify  the Shares to be
included in such  registration  statement under such securities laws or blue sky
laws of such  jurisdictions as each Purchaser and each placement or sales agent,
if any, therefor and underwriter,  if any, thereof shall reasonably request, (B)
keep such registrations or qualifications in effect and comply with such laws so
as to permit the  continuance  of  offers,  sales and  dealings  therein in such
jurisdictions  during the respective  periods such  registration  statements are
required  to remain  effective  under  Section 2 above and for so long as may be
necessary to enable each  Purchaser or any agent or  underwriter to complete its
distribution of Shares pursuant to such registration  statement and (C) take any
and all other actions as may be reasonably necessary or advisable to enable each
Purchaser, agent, if any, and underwriter, if any, to


                                       5
<PAGE>


consummate  the  disposition  in such  jurisdictions  of such Shares;  provided,
however,  that the  Company  shall not be required  for any such  purpose to (I)
qualify  as a  foreign  corporation  in any  jurisdiction  wherein  it would not
otherwise  be  required  to qualify  but for the  requirements  of this  Section
3(a)(ix) or (II) consent to general service of process in any such jurisdiction;

     (x) use its  best  efforts  to  obtain  the  consent  or  approval  of each
governmental agency or authority,  whether federal, state or local, which may be
required to effect the Shelf  Registration or the offering or sale in connection
therewith or to enable the Purchaser to offer,  or to consummate the disposition
of, its Shares;

     (xi) cooperate with each Purchaser and the managing  underwriters,  if any,
to  facilitate  the  timely   preparation  and  delivery  of  any   certificates
representing   Shares  to  be  sold,  which   certificates   shall  be  printed,
lithographed or engraved,  or produced by any  combination of such methods,  and
which shall not, once sold under the Shelf  Registration,  bear any  restrictive
legends; and, in the case of an underwritten offering,  enable such Shares to be
in such denominations and registered in such names as the managing  underwriters
may request at least two business days prior to any sale of the Shares;

     (xii) enter into one or more underwriting  agreements,  engagement letters,
agency  agreements or similar  agreements,  as appropriate,  including  (without
limitation)  customary  provisions relating to indemnification and contribution,
and take such other  actions in  connections  therewith as any  Purchaser  shall
reasonably  request in order to expedite or facilitate  the  disposition  of the
Shares;

     (xiii)  notify each  Purchaser in writing of any proposal by the Company to
amend or waive any provision of these  Registration  Rights  pursuant to Section
7(g) hereof and of any amendment or waiver effected  pursuant  thereto,  each of
which  notices  shall  contain the text of the  amendment or waiver  proposed or
effected, as the case may be;

     (xiv) in the event that any broker-dealer registered under the Exchange Act
shall  underwrite  any  Shares or  participate  as a member  of an  underwriting
syndicate or selling group or "assist in the  distribution"  (within the meaning
of the Rules of Fair  Practice  and the By-Laws of the National  Association  of
Securities  Dealers,  Inc.  ("NASD"))  thereof,  whether  as an  underwriter,  a
placement or sales agent or a broker or dealer in respect thereof, or otherwise,
assist such  broker-dealer  in complying with the requirements of such Rules and
By-Laws,  including,  without limitation,  by providing such information to such
broker-dealer as may be required in order for such  broker-dealer to comply with
the requirements of the Rules of Fair Practice of the NASD;


                                       6
<PAGE>



     (xv) comply with all applicable  rules and  regulations of the  Commission,
and make generally  available to its security holders as soon as practicable but
in any event not later than  eighteen  months after the  effective  date of such
registration  statement, an earning statement of the Company and in subsidiaries
complying with Section 11 (a) of the Securities Act (including, at the option of
the Company, Rule 158 thereunder); and

     (xvi) use its best  efforts to have the Shares  approved for trading on the
Nasdaq National Market.

     (b) In the event that the Company  would be  required,  pursuant to Section
3(a)(v)(F)  above,  to notify each  Purchaser,  the placement or sales agent, if
any, therefor and the managing underwriters,  if any, thereof, the Company shall
without delay prepare and furnish to each Purchaser,  to each placement or sales
agent, if any, and to each underwriter, if any, a reasonable number of copies of
a  prospectus   supplemented  or  amended  in  form  and  substance   reasonably
satisfactory to them, so that, as thereafter  delivered to purchasers of Shares,
such prospectus shall not contain an untrue statement of a material fact or omit
to state a material fact required to be stated  therein or necessary to make the
statements  therein not misleading in light of the circumstances  then existing.
Each Purchaser  agrees that upon receipt of any notice from the Company pursuant
to Section  3(a)(v)(F)  hereof,  such Purchaser shall forthwith  discontinue the
disposition of Shares pursuant to the registration  statement applicable to such
Shares  until such  Purchaser  shall  have  received  copies of such  amended or
supplemented prospectus, and if so directed by the Company, such Purchaser shall
deliver  to the  Company  (at the  Company's  expense)  all  copies,  other than
permanent  file copies,  then in such  Purchaser's  possession of the prospectus
covering such Shares at the time of receipt of such notice.

     (c) The Company may require any  Purchaser  to furnish to the Company  such
information  regarding such Purchaser and such  Purchaser's  intended  method of
distribution  of the  Shares as the  Company  may from  time to time  reasonably
request in writing,  but only to the extent that such information is required in
order to comply with the  Securities  Act. Each  Purchaser  agrees to notify the
Company as promptly as  practicable  of any  inaccuracy or change in information
previously  furnished by such  Purchaser to the Company or of the  occurrence of
any event in either  case as a result of which any  prospectus  relating to such
registration  contains or would  contain an untrue  statement of a material fact
regarding such Purchaser or such Purchaser's  intended method of distribution of
such Shares or omits to state any material fact regarding such Purchaser or such
Purchaser's intended method of distribution of such Shares required to be stated
therein or necessary to make the  statements  therein not misleading in light of
the  circumstances  then  existing,  and  promptly to furnish to the Company any
additional  information  required to correct and update any previously furnished
information or required so that such prospectus shall not contain,  with respect
to such Purchaser or the  distribution of such Shares,  an untrue statement of a
material fact or omit to state a material fact required to be stated  therein or
necessary  to make  the  statements  therein  not  misleading  in  light  of the
circumstances  then  existing.  Each Purchaser  agrees that upon  delivering any
notice to the Company  pursuant  to this  Section  3(c),  such  Purchaser  shall
forthwith  discontinue the  disposition of Shares  pursuant to the  registration
statement applicable to such Shares until such


                                       7
<PAGE>


Purchaser shall have received copies of such amended or supplemented prospectus,
and if so directed by the Company,  such Purchaser  shall deliver to the Company
(at the Company's expense) all copies,  other than permanent file copies then in
such Purchaser's  possession of the prospectus  covering such Shares at the time
of receipt of such notice.

     4. Registration Expenses.

     The  Company  agrees to bear and to pay or cause to be paid  promptly  upon
request being made therefor all expenses  incident to the Company's  performance
of or  compliance  with these  Registration  Rights as they  relate to the Shelf
Registration,  including,  without  limitation,  (i) all Commission and any NASD
registration  and  filing  fees and  expenses,  (ii) all  fees and  expenses  in
connection with the  qualification of the Shares for offering and sale under the
State  securities  and blue sky laws  referred  to in Section  3(a)(ix)  hereof,
including  reasonable  fees and  disbursements  of counsel for the  placement or
sales agent or underwriters in connection  with such  qualifications,  (iii) all
fees and expenses in  connection  with the approval for trading of the Shares on
the Nasdaq  National  Market,  (iv) all  expenses  relating to the  preparation,
printing,  distribution and reproduction of each registration statement required
to be  filed  hereunder,  each  prospectus  included  therein  or  prepared  for
distribution pursuant hereto, each amendment or supplement to the foregoing, the
certificates  representing  the Shares and all other documents  relating hereto,
(v) internal expenses (including,  without limitation, all salaries and expenses
of the Company's officers and employees  performing legal or accounting duties),
and (vi) fees,  disbursements and expenses of counsel and independent  certified
public  accountants  of the Company  (including  the expenses of any opinions or
"cold  comfort"  letters  required  by  or  incident  to  such  performance  and
compliance)  (collectively,  the "Registration  Expenses").  Notwithstanding the
foregoing,  such  Purchaser  shall  pay all  agency  fees  and  commissions  and
underwriting  discounts and  commissions  attributable to the sale of the Shares
and the fees and  disbursements  of any  counsel  or other  advisors  or experts
retained by such Purchaser in connection with the sale of its shares.

     5. Representations and Warranties.

     The Company represents and warrants to, and agrees with, each
Purchaser that:

     (a)  Each  registration  statement  covering  Shares  and  each  prospectus
(including any preliminary or summary prospectus) contained therein or furnished
pursuant to Section  3(a)(viii) hereof and any further amendments or supplements
to any such registration  statement or prospectus,  when it becomes effective or
is  filed  with the  Commission,  as the  case  may be,  and,  in the case of an
underwritten  offering  of  Shares,  at  the  time  of  the  closing  under  the
underwriting agreement relating thereto will conform in all material respects to
the requirements of the Securities Act, and will not contain an untrue statement
of a  material  fact or omit to state a  material  fact  required  to be  stated
therein or necessary to make the statements  therein not misleading;  and at all
times subsequent to the Effective Time when a prospectus would be required to be
delivered  under the  Securities  Act, other than from (i) such time as a notice
has been give to such Purchaser  pursuant to Section 3(a)(v)F) hereof until (ii)
such  time as the  Company  furnishes  an  amended  or  supplemented  prospectus
pursuant to Section  3(b) hereof,  each such  registration  statement,  and each
prospectus


                                       8
<PAGE>


(including any summary  prospectus)  contained therein or furnished  pursuant to
Section 3(a)(viii) hereof, as then amended or supplemented,  will conform in all
material  respects  to the  requirements  of the  Securities  Act,  and will not
contain an untrue  statement of a material fact or omit to state a material fact
required to be stated  therein or necessary to make the  statements  therein not
misleading in the light of the circumstances then existing;  provided,  however,
that this  representation  and  warranty  shall not apply to any  statements  or
omissions made in reliance upon and in conformity with information  furnished in
writing to the Company by such Purchaser expressly for use therein.

     (b) Any documents  incorporated by reference in any prospectus  referred to
in Section  5(a)  hereof,  when they become or became  effective  or are or were
filed with the Commission, or if amended, when amended, as the case may be, will
conform  or  conformed  in all  material  respects  to the  requirements  of the
Exchange  Act,  and none of such  documents  will contain or contained an untrue
statement  of a material  fact or will omit or omitted to state a material  fact
required to be stated  therein or necessary to make the  statements  therein not
misleading;  provided,  however, that this representation and warranty shall not
apply to any  statements  or omissions  made in reliance  upon and in conformity
with information furnished in writing to the Company by such Purchaser expressly
for use therein.

     6. Indemnification.


     (a)  Indemnification  by the  Company.  Upon  the  registration  of  Shares
pursuant to Section 2 hereof,  and in  consideration  of the  agreements  of the
Purchasers  contained herein, and as an inducement to the Purchasers to purchase
the Convertible Notes, the Company shall, and it hereby agrees to, indemnify and
hold harmless each Purchaser and each person who  participates as a placement or
sales agent or as an  underwriter in any offering or sale of such Shares against
any losses,  claims,  damages or  liabilities,  joint or several,  to which such
Purchaser  or any  such  agent or  underwriter  may  become  subject  under  the
Securities  Act or  otherwise,  insofar  as  such  losses,  claims,  damages  or
liabilities  (or actions in respect  thereof)  arise out of or are based upon an
untrue statement or alleged untrue statement of a material fact contained in any
registration  statement  under  which  such  Shares  were  registered  under the
Securities  Act,  or any  preliminary,  final or  summary  prospectus  contained
therein or furnished by the Company to such Purchaser, agent or underwriter,  or
any  amendment  or  supplement  thereto,  or arise out of or are based  upon the
omission or alleged  omission to state  therein a material  fact  required to be
stated therein or necessary to make the statements  therein not misleading,  and
the Company shall, and it hereby agrees to, reimburse such Purchaser, such agent
and such underwriter for any legal or other expenses reasonably incurred by them
in connection with  investigating  or defending any such action or claim as such
expenses are incurred;  provided,  however, that the Company shall not be liable
to any such  Person in any such case to the extent  that any such  loss,  claim,
damage  or  liability  arises  out of or is based  upon an untrue  statement  or
alleged  untrue   statement  or  omission  or  alleged  omission  made  in  such
registration statement or preliminary, final or summary prospectus, or amendment
or  supplement  in reliance  upon and in  conformity  with  written  information
furnished  to the Company by such Person  expressly  for use  therein;  provided
further,  however,  that the  Company  shall not be liable to any such Person if
such Person failed to deliver a prospectus in the form most recently provided by
the Company (including any amendments or supplements thereto previously provided
by the


                                       9
<PAGE>



Company),  in any such  case to the  extent  that any  loss,  claim,  damage  or
liability  arises out of or is based  upon an untrue  statement  or an  omission
which was corrected in such most recently  furnished  prospectus  (including any
such amendments or supplements).

     (b)  Indemnification by the Purchaser and any Agents and Underwriters.  The
Company may require,  as a condition to including any Shares in any registration
statement   filed  pursuant  to  Section  2  hereof  and  to  entering  into  an
underwriting  agreement,  if any, with respect  thereto,  that the Company shall
have  received  an  undertaking   reasonably   satisfactory   to  it  from  each
participating  Purchaser and from each  underwriter,  if any,  named in any such
underwriting  agreement,  severally and not jointly or jointly and severally, to
(i) indemnify and hold harmless the Company against any losses,  claims, damages
or liabilities to which the Company may become subject, under the Securities Act
or otherwise, insofar as such losses, claims, damages or liabilities (or actions
in  respect  thereof')  arise out of or are based  upon an untrue  statement  or
alleged  untrue  statement of a material  fact  contained  in such  registration
statement, or any preliminary,  final or summary prospectus contained therein or
furnished  by the  Company  to  any  Purchaser,  agent  or  underwriter,  or any
amendment or supplement  thereto, or arise out of or are based upon the omission
or alleged  omission  to state  therein a material  fact  required  to be stated
therein or necessary to make the statements therein not misleading, in each case
to the extent,  but only to the extent,  that such untrue  statement  or alleged
untrue  statement or omission or alleged  omission was made in reliance upon and
in  conformity  with  written  information  furnished  to the  Company  by  such
Purchaser or  underwriter  expressly  for use therein,  and (ii)  reimburse  the
Company for any legal or other  expenses  reasonably  incurred by the Company in
connection  with  investigating  or  defending  any such action or claim as such
expenses  are  incurred.  Notwithstanding  the  above,  the  obligation  of such
Purchaser for indemnity  shall be limited to an amount equal to the net proceeds
received by such Purchaser in the applicable underwriting.

     (c) Notices of Claims,  Etc. Promptly after receipt by an indemnified party
under  subsection (a) or (b) above of written notice of the  commencement of any
action,  such  indemnified  party shall,  if a claim in respect thereof is to be
made against an indemnifying party pursuant to the indemnification provisions of
or contemplated by this Section 6, notify such indemnifying  party in writing of
the commencement of such action;  but the omission so to notify the indemnifying
party  shall  not  relieve  it  from  any  liability  which  it may  have to any
indemnified  party  other  than  under  the  indemnification  provisions  of  or
contemplated  by Section 6(a) or 6(b)  hereof.  In case any such action shall be
brought against any indemnified party and it shall notify an indemnifying  party
of the  commencement  thereof,  such  indemnifying  party  shall be  entitled to
participate  therein  and, to the extent that it shall  wish,  jointly  with any
other indemnifying party similarly notified, to assume the defense thereof, with
counsel  satisfactory to such indemnified  party (who shall not, except with the
consent of the indemnified  party, be counsel to the indemnifying  party),  and,
after  notice  from  the  indemnifying  party to such  indemnified  party of its
election so to assume the defense thereof,  such indemnifying party shall not be
liable to such indemnified  party for any legal expenses of other counsel or any
other expenses, in each case subsequently incurred by such indemnified party, in
connection with the defense thereof other than reasonable costs of investigation
unless, in the case of an indemnification  obligation arising under Section (a),
(i) the employment of such additional  counsel has been authorized in writing by
the Company in connection with defending such action,


                                       10
<PAGE>


or (ii) the Company and the  Purchaser  are advised by such  additional  counsel
that the Purchaser has available  defenses  involving a potential  conflict with
the  interests  of the Company,  in which  event,  the fees and expenses of such
additional  counsel shall be borne by the Company.  No indemnifying  party shall
consent to entry of any judgment or enter into any settlement of a claim against
an indemnified party without the consent of the indemnified party which does not
include as an unconditional term thereof the giving by the claimant or plaintiff
to such  indemnified  party of an  unconditional  release from all  liability in
respect to such claim or litigation.

     (d)  Contribution.  Each party hereto  agrees  that,  if for any reason the
indemnification  provisions  contemplated  by Section  6(a) or Section  6(b) are
unavailable to or insufficient to hold harmless an indemnified  party in respect
of any losses,  claims,  damages or liabilities (or actions in respect  thereof)
referred to therein, then each indemnifying party shall contribute to the amount
paid or payable by such  indemnified  party as a result of such losses,  claims,
damages or liabilities (or actions in respect  thereof) in such proportion as is
appropriate to reflect the relative  benefits  received by indemnified  party on
the one hand and the  indemnifying  party on the other from any  offering of the
Shares.  If,  however,  the  allocation  provided by the  immediately  preceding
sentence is not permitted by applicable law or if the  indemnified  party failed
to give the notice required under subsection (c) above,  then each  indemnifying
party shall contribute to such amount paid or payable by such indemnified  party
in such proportion as is appropriate to reflect not only such relative  benefits
but also the relative fault of the indemnifying  party and the indemnified party
in connection  with the  statements or omissions  which resulted in such losses,
claims,  damages or liabilities (or actions in respect thereof),  as well as any
other relevant equitable  considerations.  The relative benefits received by the
Company on the one hand and each Purchaser on the other shall be deemed to be in
the same  proportion as the total  purchase  price  received by the Company upon
issuance of the  Convertible  Note bears to the difference  between the proceeds
from the offering of the Shares  received by such  Purchaser  and such  purchase
price. The relative fault of such indemnifying party and indemnified party shall
be determined by reference to, among other things, whether the untrue or alleged
untrue  statement of a material fact or omission or alleged  omission to state a
material fact relates to information  supplied by such indemnifying  party or by
such indemnified party, and the parties' relative intent,  knowledge,  access to
information  and  opportunity  to correct or prevent such statement or omission.
The  parties   hereto  agree  that  it  would  not  be  just  and  equitable  if
contributions  pursuant  to  this  Section  6(d)  were  determined  by pro  rata
allocation  (even if any Purchaser or any agents or  underwriters or all of them
were  treated  as one  entity  for  such  purpose)  or by any  other  method  of
allocation which does not take account of the equitable  considerations referred
to in this Section 6(d). The amount paid or payable by an indemnified party as a
result of the losses,  claims,  damages,  or liabilities  (or actions in respect
thereof) referred to above shall be deemed to include any legal or other fees or
expenses  reasonably  incurred  by such  indemnified  party in  connection  with
investigating  or  defending  any such  action  or  claim.  Notwithstanding  the
provisions of this Section  6(d),  no Purchaser  shall be required to contribute
any amounts in excess of the amount by which the dollar  amount of the  proceeds
received by such  Purchaser  from the sale of any Shares  (after  deducting  any
fees,  discounts and commissions  applicable  thereto) exceeds the amount of any
damages which such  Purchaser  has  otherwise  been required to pay by reason of
such untrue or alleged untrue statement or omission or alleged omission,  and no
underwriter  shall be required to contribute  any amount in excess of the amount
by


                                       11
<PAGE>



which the total price at which the Shares  underwritten by it and distributed to
the public were  offered to the public  exceeds the amount of any damages  which
such  underwriter has otherwise been required to pay by reason of such untrue or
alleged untrue  statement or omission or alleged  omission.  No person guilty of
fraudulent  misrepresentation  (within  the  meaning  of  Section  11 (f) of the
Securities  Act) shall be  entitled  to  contribute  from any person who was not
guilty of such fraudulent  misrepresentation.  Any underwriters'  obligations in
this Section 6(d) to contribute  shall be several in proportion to the principal
amount of Shares underwritten by them and not joint.

     (e) The  obligations  of the  Company  under  this  Section  6 shall  be in
addition to any liability which the Company may otherwise have and shall extend,
upon the same terms and  conditions,  to each  officer,  director and partner of
each  Purchaser,  any agent and any  underwriter  and each  person,  if any, who
controls such  Purchaser or any agent or  underwriter  within the meaning of the
Securities  Act;  and the  obligations  of each  Purchaser  and any  agents  and
underwriters  contemplated  by  this  Section  6  shall  be in  addition  to any
liability which such Purchaser or any such agent or  underwriter,  respectively,
may otherwise have and shall extend, upon the same terms and conditions, to each
officer and director of the Company (including any person who, with his consent,
is named in any  registration  statement  as about to become a  director  of the
Company) and to each person, if any, who controls the Company within the meaning
of the Securities Act.

     7. Miscellaneous

     (a) No Inconsistent Agreements. The Company represents, warrants, covenants
and agrees that it has not  granted,  and shall not grant,  registration  rights
with respect to Shares or any other  securities  which would  conflict  with the
terms contained in these Registration Rights.


     (b) Specific Performance.  The parties hereto acknowledge that there may be
no adequate  remedy at law if any party fails to perform any of its  obligations
hereunder and that each party may be irreparably harmed by any such failure, and
accordingly  agree that each party,  in addition to any other remedy to which it
may be  entitled  at law or in  equity,  shall be  entitled  to compel  specific
performance of the obligations of any other party under the Registration  Rights
in accordance with the terms and conditions of these Registration Rights, in any
court of the United States or any State thereof having jurisdiction.

     (c) Notices. Any notice or other communication  required or permitted to be
given hereunder  shall be deemed  effectively  given when personally  delivered,
telexed,  transmitted by facsimile or mailed by pre-paid  certified mail, return
receipt  requested,  or by  telephone  when  confirmed  in writing by one of the
preceding methods addressed as follows (as applicable):

     If to the Company, to:


     Celgene Corporation
     7 Powder Horn Drive
     Warren, NJ 07059


                                       12
<PAGE>



     Attention:  John W. Jackson
     Telephone  Number:  (732)  271-1001
     Facsimile Transmission Number: (732) 805-3931

     with a copy to:

     Proskauer Rose LLP
     1585 Broadway
     New York, NY 10036

     Attention: Robert A. Cantone, Esq.
     Telephone Number: (212) 969-3000
     Facsimile Transmission Number: (212) 969-2900

     If to Purchasers,  to the Person designated by Purchaser and at the address
     as set forth on Schedule I in the Note  Purchase  Agreement  dated the date
     hereof between the Purchasers and the Company

     with a copy to:

     Choate, Hall & Stewart
     Exchange Place
     53 State Street
     Boston, MA 02109

     Attention: Frank B. Porter, Jr.
     Telephone Number: (617) 248-5000
     Facsimile Transmission Number: (617) 248-4000

or to such other  address or number and to the attention of such other person as
either party may designate by written notice to the other party. Notice shall be
effective upon actual receipt.

     (d) Survival.  The  respective  indemnities,  agreements,  representations,
warranties and each other  provision set forth in these  Registration  Rights or
made  pursuant  hereto shall remain in full force and effect  regardless  of any
investigation  (or statement as to the results  thereof) made by or on behalf of
each Purchaser, any director, officer or partner of such Purchaser, any agent or
underwriter  or any director,  officer or partner  thereof,  or any  controlling
person of any of the  foregoing  and shall survive the transfer of the Shares by
such Purchaser.

     (e) Law  Governing.  These  Registration  Rights  shall be  governed by and
construed in accordance with the laws of the State of New York.

     (f)  Headings.  The  descriptive  headings  of  the  several  Sections  and
paragraphs of these  Registration  Rights are inserted for convenience  only, do
not constitute a part of these



                                       13
<PAGE>


Registration   Rights  and  shall  not   affect  in  any  way  the   meaning  or
interpretation of these Registration Rights.

     (g) Entire Agreement;  Amendments.  These Registration Rights and the other
writings  referred  to herein or  delivered  pursuant  hereto  which form a part
hereof  contain  the entire  understanding  of the parties  with  respect to its
subject matter.  These  Registration  Rights  supersede all prior agreements and
understandings  between the parties  with respect to its subject  matter.  These
Registration  Rights  may be  amended  and the  observance  of any term of these
Registration  Rights may be waived (either generally or in a particular instance
and either  retroactively or  prospectively)  only be a written  instrument duly
executed by the Company and each Purchaser.


     (h)  Assignment.   In  connection  with  any  permitted   transfer  of  the
Convertible  Note or any portion thereof in a principal  amount of not less than
$100,000  any  Purchaser  may  assign its  rights  hereunder  in respect of such
Convertible Note to the transferee.  Upon such assignment the transferee  shall,
insofar as the transferred  Convertible Notes are concerned,  be entitled to all
of the rights,  and be subject to all of the  obligations,  of a Purchaser under
these  Registration  Rights, and all references to such "Purchaser" herein shall
thereafter be deemed to refer to the Purchaser, or such transferee,  or both, as
the circumstances warrant.

     (i)   Counterparts.   This   agreement  may  be  executed  by  the  parties
counterparts,  each of which  shall be  deemed to be an  original,  but all such
respective counterparts shall together constitute one and the same instrument.

     [the remainder of this page is intentionally left blank]




                                       14
<PAGE>


                 Signature Page of Registration Rights Agreement

            Agreed to and accepted as of the date referred to above,

CELGENE CORPORATION

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------

     JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------

     JOHN HANCOCK VARIABLE LIFE INSURANCE COMPANY

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------

     SIGNATURE 1 A (CAYMAN), LTD.
     By: John Hancock Mutual Life Insurance
              Company, Portfolio Advisor

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------

<PAGE>


                 Signature Page of Registration Rights Agreement

            Agreed to and accepted as of the date referred to above,

     CELGENE CORPORATION

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------


     JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------

     JOHN HANCOCK VARIABLE LIFE INSURANCE COMPANY

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------

     SIGNATURE lA (CAYMAN), LTD.
     By: John Hancock Mutual Life Insurance
           Company, Portfolio Advisor

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------



<PAGE>



                 Signature Page of Registration Rights Agreement

            Agreed to and accepted as of the date referred to above.


     CELGENE CORPORATION

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:
           --------------------------------

     JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title: Senior Investment Officer
           --------------------------------

     JOHN HANCOCK VARIABLE LIFE INSURANCE COMPANY

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title: Senior Investment Officer
           --------------------------------

     SIGNATURE lA (CAYMAN), LTD.
     By: John Hancock Mutual Life Insurance
     Company, Portfolio Advisor

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title: Senior Investment Officer
           --------------------------------


<PAGE>

            Signature Page of Registration Rights Agreement Continued

Signature 3 Limited
By: John Hancock Mutual Life Insurance Company,
         as Portfolio Advisor

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title:  Senior Investment Officer
           --------------------------------

Hancock Mezzanine Partners L.P.
By: Hancock Mezzanine Investments LLC, its General Partner
By: John Hancock Mutual Life Insurance Company.
                  as Investment Manager

     By:
        -----------------------------------
     Name:
          ---------------------------------
     Title: Senior Investment Officer
           --------------------------------





                                                                   EXHIBIT 10.25
                                                                  CONFORMED COPY

                             NOTE PURCHASE AGREEMENT


                                                                    July 6, 1999

To the Purchasers
listed on attached
Schedule I

Dear Sirs:

     CELGENE  CORPORATION (the "Company") wishes to confirm its arrangement with
the  Purchasers  named on Schedule I to this  Agreement  (the  "Purchasers"  and
singly each  "Purchaser")  in  connection  with the issuance to the  Purchasers,
against payment in immediately  available funds of the purchase price of 100% of
the principal  amount thereof,  of one or more senior  convertible  notes in the
form attached hereto as Exhibit A (collectively  the "Convertible  Notes") in an
aggregate principal amount of $15,000,000 and convertible initially into 789,474
fully paid and  non-assessable  shares (each a "Share") of the Company's  Common
Stock, par value $.01 per share (the "Common  Stock"),  subject to adjustment as
set forth in the Convertible Notes.

     Simultaneously  with the issuance of the Convertible Notes pursuant to this
Agreement,  the Company and the  Purchasers  have  entered  into a  Registration
Rights  Agreement,   dated  as  of  the  date  hereof(the  "Registration  Rights
Agreement"),  pursuant to which the  Company  has agreed to register  the Shares
under certain circumstances.  Any capitalized term not defined herein shall have
the meaning ascribed to such term in the Convertible Notes.

     1. AGREEMENT TO ISSUE AND ACCEPT. On the basis of the  representations  and
warranties  made by the  Company  to  induce  the  Purchasers  to  purchase  the
Convertible Notes and subject to the terms and conditions set forth herein,  the
Company will issue to each  Purchaser,  and each  Purchaser will accept from the
Company,  the Convertible Notes in the principal amount specified  opposite such
Purchaser's  name on Schedule I attached hereto at the purchase price of 100% of
the principal  amount thereof  against payment of the  above-specified  purchase
price  therefor.  The closing (the  "Closing") of the issuance and acceptance of
the Convertible  Notes against such payment shall take place on the date hereof,
at which time the Company shall deliver to each Purchaser the Convertible Notes,
against  delivery by each  Purchaser of a wire transfer of the purchase price to
the Company's account at PNC Bank New Jersey Trust, ABA No.  031000053,  benefit
Account  No.  8511074024,  for  further  credit to Account  No.  42432012020943,
Celgene Corporation, Attn: Lisa Goldhammer,  Telephone No. (732) 220-3112. If at
the  Closing  the  Company  shall fail to tender the  Convertible  Notes to each
Purchaser  as provided in this Section 1 or any of the  conditions  specified in
Section


<PAGE>


     2.  REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company hereby makes
the  representations  and  warranties  set  forth  on  Annex  II  hereto  to the
Purchasers.

     3.  AGREEMENTS OF PURCHASER.  Each Purchaser  covenants and agrees with the
Company that:

     (a) Such Purchaser will not offer, sell,  assign,  hypothecate or otherwise
transfer the Convertible Notes except (i) pursuant to an effective  registration
statement  under the  Securities  Act of 1933 (the "Act"),  (ii) to a person you
reasonably believe to be an "accredited investor" within the meaning of Rule 501
under the Act,  pursuant  to an  available  exemption  under the Act or (iii) in
offshore  transactions  within the meaning and meeting the  requirements of Rule
903 under the Act.

     (b) Such Purchaser will not offer, sell,  assign,  hypothecate or otherwise
transfer any Shares issued upon conversion of the  Convertible  Notes except (i)
pursuant to an effective  registration statement under the Act; (ii) to a person
you reasonably believe to be an "accredited investor" within the meaning of Rule
501 under the Act, pursuant to an available  exemption under the Act or (iii) in
an offshore  transaction within the meaning and meeting the requirements of Rule
903 under the Act.

     (c) Such Purchaser is an "accredited  investor"  within the meaning of Rule
501 under the Act.

     (d)  During the  period  that the  Company  is  prohibited  from  making an
optional  redemption  under  Section  1 of the  Convertible  Note,  so long as a
Purchaser holds a Convertible  Note, such Purchaser shall not undertake any form
of short sale,  derivative or other transaction which has the effect of taking a
"short  position" in the Common  Stock of the Company to hedge such  Purchaser's
investment in the Company, provided, however, that no affiliate of any Purchaser
shall be  subject  to the  provisions  of this  subsection  3(d).  The  covenant
contained in this Section 3(d) shall be,  subject to the  limitations  contained
herein, binding on any holder of a Convertible Note.

     (e) Each Purchaser represents that at least one of the following statements
is an accurate representation as to each source of funds (a "Source") to be used
by such  Purchaser  to pay the  purchase  price of the  Convertible  Notes to be
purchased by it hereunder:

     (i) the Source is an "insurance company general account" within the meaning
of Department of Labor Prohibited  Transaction  Exemption  ("PTE") 95-60 (issued
July 12, 1995) and there is no employee benefit plan,  treating as a single plan
all plans,  maintained by the same employer (or affiliate  thereof as defined in
Section  V(a)(1) of PTE 95-60) or employee  organization,  with respect to which
the amount of the general  account  reserves and  liabilities  for all contracts
held by or on  behalf  of such  plan  exceeds  ten  percent  (10%) of the  total
reserves and liabilities of such general account  (exclusive of separate account
liabilities) plus surplus,  as set forth in the NAIC Annual Statement filed with
such Purchaser's state of domicile; or



                                       2
<PAGE>



     (ii) the Source is either (a) an insurance company pooled separate account,
within the meaning of  Prohibited  Transaction  Exemption  CPTE")  90-1  (issued
January 29, 1990), or (b) a bank collective  investment fund, within the meaning
of the PTE 91-38 (issued July 12, 1991) and, except as you have disclosed to the
Company in writing  pursuant to this paragraph (ii), no employee benefit plan or
group  of  plans  maintained  by the  same  employer  or  employee  organization
beneficially  owns more than 10% of all assets allocated to such pooled separate
account or collective investment fund; or

     (iii) the Source  constitutes  assets of an  "investment  fund" (within the
meaning of Part V of the QPAM  Exemption)  managed by a "qualified  professional
asset manager" or "QPAM" (within the meaning of Part V of the QPAM  'Exemption),
no employee  benefit  plan's assets that are included in such  investment  fund,
when combined with the assets of all other employee benefit plans established or
maintained  by the same  employer  or by an  affiliate  (within  the  meaning of
Section  V(c)(1) of the QPAM Exemption) of such employer or by the same employee
organization  and managed by such QPAM,  exceed 20% of the total  client  assets
managed by such QPAM,  the conditions of Part I(c) and (g) of the QPAM Exemption
are  satisfied,  neither the QPAM nor a person  controlling or controlled by the
QPAM  (applying  the  definition  of  "control"  in  Section  V(e)  of the  QPAM
Exemption)  owns a 5 % or more  interest in the Company and (a) the  identity of
such QPAM and (b) the names of all  employee  benefit  plans  whose  assets  are
included in such  investment  fund have been disclosed to the Company in writing
pursuant to this paragraph (iii); or

     (iv) the Source is a governmental plan; or

     (v) the Source is one or more employee benefit plans, or a separate account
or trust fund comprised of one or more employee benefit plans, each of which has
been identified to the Company in writing pursuant to this paragraph (e); or

     (vi) the Source does not include assets of any employee benefit plan, other
than a plan exempt from the coverage of ERISA.

As used in this Section 3(e), the terms "employee  benefit plan",  "governmental
plan",  "party in interest" and  "separate  account"  shall have the  respective
meanings assigned to such terms in Section 3 of ERISA.

Prior to any holder of this Security  transferring this Security,  the holder of
this  Security  shall  provide  a  certificate  from  such  proposed  subsequent
transferee   wherein  such  proposed   subsequent   transferee  shall  make  the
representations made in this Section 3(e) and shall  simultaneously  deliver any
disclosure letter required under Section 3(e)(iii). Such subsequent transferee's
failure to deliver such a certificate  shall not relieve the Company from any of
the terms, covenants or conditions of this Security.



                                       3
<PAGE>



     4.  AGREEMENTS OF THE COMPANY.  From and after the date of this  Agreement,
and thereafter so long as any of the Convertible Notes remain  outstanding,  the
Company  will duly  perform and  observe,  for the benefit of the holders of the
Convertible Notes, each and all of the covenants and agreements  hereinafter set
forth:

     (a) The Company shall deliver to each holder of a Convertible Note:

     i.  Quarterly  Statements -- upon the earlier of (x) when the Company files
its Form 10-Q with the  Securities  and Exchange  Commission for a fiscal period
and (y) 50 days after the end of each  quarterly  fiscal  period in each  fiscal
year of the Company  (other than the last  quarterly  fiscal period of each such
fiscal year), duplicate copies of,

     (1) a consolidated  balance sheet of the Company and its Subsidiaries as at
the end of such quarter, and

     (2) consolidated  statements of income, changes in shareholders' equity and
cash flows of the Company  and its  Subsidiaries,  for such  quarter and (in the
case of the second and third quarters) for the portion of the fiscal year ending
with such quarter,

setting forth in each case in comparative form the figures for the corresponding
periods in the  previous  fiscal year,  all in  reasonable  detail,  prepared in
accordance with GAAP applicable to quarterly financial statements generally, and
certified by a Senior Financial  Officer as fairly  presenting,  in all material
respects,  the financial  position of the companies  being reported on and their
results of operations and cash flows, subject to changes resulting from year-end
adjustments,  provided that delivery  within the time period  specified above of
copies of the  Company's  Quarterly  Report on Form 10-Q  prepared in compliance
with the  requirements  therefor  and filed  with the  Securities  and  Exchange
Commission shall be deemed to satisfy the requirements of this Section 4(a)(i);

     ii. Annual  Statements -- upon the earlier of(x) when the Company files its
Form 10-K with the  Securities  and Exchange  Commission for a fiscal period and
(y) 105 days after the end of each fiscal year of the Company,  duplicate copies
of,

     (1) a consolidated balance sheet of the Company and its Subsidiaries, as at
the end of such year, and

     (2) consolidated  statements of income, changes in shareholders' equity and
cash flows of the Company and its Subsidiaries, for such year,

setting  forth in each case in  comparative  form the figures  for the  previous
fiscal year,  all in reasonable  detail,  prepared in accordance  with GAAP, and
accompanied


                                       4
<PAGE>


     (A) by an opinion thereon of independent  certified  public  accountants of
recognized  national  standing,  which  opinion  shall state that  suchfinancial
statements present fairly, in all material  respects,  the financial position of
the companies being reported upon and their results of operations and cash flows
and have been prepared in conformity with GAAP, and that the examination of such
accountants  in  connection  with  such  financial  statements  has been made in
accordance  with  generally  accepted  auditing  standards,  and that such audit
provides a reasonable basis for such opinion in the circumstances, and

     (B) a certificate of such accountants  stating that they have reviewed this
Agreement and stating further whether,  in making their audit,  they have become
aware of any  condition or event that then  constitutes a Default or an Event of
Default,  and, if they are aware that any such  condition  or event then exists,
specifying the nature and period of the existence  thereof (it being  understood
that such  accountants  shall not be liable,  directly  or  indirectly,  for any
failure to obtain  knowledge  of any  Default or Event of  Default  unless  such
accountants  should  have  obtained  knowledge  thereof  in  making  an audit in
accordance with generally  accepted  auditing  standards or did not make such an
audit),

provided  that the  delivery  within  the  time  period  specified  above of the
Company's  Annual  Report on Form 10-K for such fiscal year  (together  with the
Company's annual report to shareholders, if any, prepared pursuant to Rule 14a-3
under the Exchange Act) prepared in accordance  with the  requirements  therefor
and  filed  with the  Securities  and  Exchange  Commission,  together  with the
accountant's  certificate  described  in clause  (B)  above,  shall be deemed to
satisfy the requirements of this Section 4(a)(ii);

     iii. SEC and Other Reports -- promptly upon their becoming  available,  one
copy of (i) each financial statement,  report, notice or proxy statement sent by
the Company or any Subsidiary to public securities holders  generally,  and (ii)
each regular or periodic  report,  each  registration  statement that shall have
become  effective  (without  exhibits  except  as  expressly  requested  by such
holder),  and each prospectus and all amendments thereto filed by the Company or
any  Subsidiary  with the  Securities  and Exchange  Commission and of all press
releases and statements in the nature  thereof made  available  generally by the
Company  or any  Subsidiary  to the  public  concerning  developments  that  are
Material;

     iv.  Notice of Default or Event of  Default --  promptly,  and in any event
within five days after a Responsible  Officer becoming aware of the existence of
any Default or Event of Default or that any Person has given any notice or taken
any action with respect to a claimed default under any of the Convertible  Notes
or that any Person has given any  notice or taken any action  with  respect to a
claimed default of the type referred to in Section


                                       5
<PAGE>



4(a)(7) of the  Convertible  Notes, a written  notice  specifying the nature and
period of existence thereof and what action the Company is taking or proposes to
take with respect thereto;

     v. ERISA  Matters --  promptly,  and in any event  within five days after a
Responsible  Officer  becoming aware of any of the  following,  a written notice
setting forth the nature thereof and the action,  if any, that the Company or an
ERISA Affiliate proposes to take with respect thereto:

     (1) with respect to any Plan, any reportable  event,  as defined in section
4043(c) of ERISA and the  regulations  thereunder,  for which notice thereof has
not been waived pursuant to such regulations as in effect on the date hereof; or

     (2) the taking by the PBGC of steps to institute, or the threatening by the
PBGC of the  institution  of,  proceedings  under  section 4042 of ERISA for the
termination of, or the appointment of a trustee to administer,  any Plan, or the
receipt by the Company or any ERISA  Affiliate of a notice from a  Multiemployer
Plan  that  such  action  has  been  taken  by the  PBGC  with  respect  to such
Multiemployer Plan; or

     (3) any event, transaction or condition that could result in the incurrence
of any liability by the Company or any ERISA Affiliate pursuant to Title I or IV
of ERISA or the  penalty  or  excise  tax  provisions  of the Code  relating  to
employee  benefit plans,  or in the imposition of any Lien on any of the rights,
properties or assets of the Company or any ERISA  Affiliate  pursuant to Title I
or IV of ERISA or such penalty or excise tax  provisions,  if such  liability or
Lien,  taken  together with any other such  liabilities  or Liens then existing,
could reasonably be expected to have a Material Adverse Effect;

     vi.  Notices from  Governmental  Authority  --  promptly,  and in any event
within  thirty days of receipt  thereof,  copies of any notice to the Company or
any Subsidiary from any Federal or state Governmental  Authority relating to any
order,  ruling,  statute or other law or  regulation  that could  reasonably  be
expected to have a Material Adverse Effect; and

     vii. Requested Information -- with reasonable  promptness,  such other data
and  information  relating  to  the  business,  operations,  affairs,  financial
condition,  assets or  properties of the Company or any of its  Subsidiaries  or
relating to the ability of the Company to perform its obligations  hereunder and
under the Convertible Notes as from time to time may be reasonably  requested by
any such holder of Convertible Notes.

     (b) The  Company  shall  permit  the  representatives  of each.  holder  of
Convertible
Notes:


                                       6
<PAGE>



     i. No Default -- if no Default  or Event of  Default  then  exists,  at the
expense of such holder and upon reasonable prior notice to the Company, to visit
the principal executive office of the Company, to discuss the affairs,  finances
and accounts of the Company and its  Subsidiaries  with the Company's  officers,
and (with the consent of the Company,  which  consent  will not be  unreasonably
withheld)  its  independent  public  accountants,  and (with the  consent of the
Company,  which  consent will not be  unreasonably  withheld) to visit the other
offices  and  properties  of the  Company  and  each  Subsidiary,  all  at  such
reasonable times and as often as may be reasonably requested in writing; and

     ii. Default -- if a Default or Event of Default then exists, at the expense
of the  Company to visit and inspect  any of the  offices or  properties  of the
Company or any  Subsidiary,  to examine all their  respective  books of account,
records, reports and other papers, to make copies and extracts therefrom, and to
discuss their  respective  affairs,  finances and accounts with their respective
officers and independent  public  accountants (and by this provision the Company
authorizes said accountants to discuss the affairs, finances and accounts of the
Company  and  its  Subsidiaries),  all at  such  times  and as  often  as may be
requested.

     (c) The Company will and will cause each of its Subsidiaries to comply with
all laws,  ordinances or governmental rules or regulations to which each of them
is subject, including,  without limitation,  Environmental Laws, and will obtain
and maintain in effect all licenses, certificates, permits, franchises and other
governmental  authorizations  necessary  to the  ownership  of their  respective
properties or to the conduct of their respective businesses, in each case to the
extent  necessary to ensure that  non-compliance  with such laws,  ordinances or
governmental  rules or  regulations  or failures to obtain or maintain in effect
such  licenses,   certificates,   permits,  franchises  and  other  governmental
authorizations  could  not,  individually  or in the  aggregate,  reasonably  be
expected to have a Material Adverse Effect.

     (d) The Company will and will cause each of its  Subsidiaries  to maintain,
with financially sound and reputable  insurers,  insurance with respect to their
respective  properties and businesses against such casualties and contingencies,
of  such  types,  on such  terms  and in such  amounts  (including  deductibles,
co-insurance  and  self-insurance,  if adequate  reserves  are  maintained  with
respect  thereto)  as is  customary  in the  case  of  entities  of  established
reputations engaged in the same or a similar business and similarly situated.

     (e) The Company  will and will cause each of its  Subsidiaries  to maintain
and keep, or cause to be maintained  and kept,  their  respective  properties in
good repair, working order and condition (other than ordinary wear and tear), so
that the business carried on in connection  therewith may be properly  conducted
at all times,  provided  that this Section  shall not prevent the Company or any
Subsidiary  from  discontinuing  the operation and the maintenance of any of its
properties  if such  discontinuance  is desirable in the conduct of its business
and the Company has concluded that such discontinuance  could not,  individually
or in the aggregate, reasonably be expected to have a Material Adverse Effect.



                                       7
<PAGE>



     (f) The Company  will and will cause each of its  Subsidiaries  to file all
tax returns  required to be filed in any  jurisdiction  and to pay and discharge
all taxes  shown to be due and  payable  on such  returns  and all other  taxes,
assessments,  governmental  charges,  or levies  imposed on them or any of their
properties,  assets,  income  or  franchises,  to  the  extent  such  taxes  and
assessments  have become due and payable and before they have become  delinquent
and all  claims for which sums have  become due and  payable  that have or might
become a Lien on properties or assets of the Company or any Subsidiary, provided
that neither the Company nor any Subsidiary  need pay any such tax or assessment
or claims if (i) the amount,  applicability  or validity thereof is contested by
the  Company  or  such  Subsidiary  on a  timely  basis  in  good  faith  and in
appropriate  proceedings,  and  the  Company  or a  Subsidiary  has  established
adequate  reserves  therefor in accordance with GAAP on the books of the Company
or such  Subsidiary or (ii) the nonpayment of all such taxes and  assessments in
the  aggregate  could not  reasonably  be  expected  to have a Material  Adverse
Effect.

     (g) The  Company  will at all  times  preserve  and keep in full  force and
effect its corporate existence.  The Company will at all times preserve and keep
in full force and effect the  corporate  existence  of each of its  Subsidiaries
(unless  merged into the Company or a Subsidiary)  and all rights and franchises
of the Company and its  Subsidiaries  unless,  in the good faith judgment of the
Company,  the  termination  of or failure to preserve and keep in full force and
effect such corporate existence,  right or franchise could not,  individually or
in the aggregate, have a Material Adverse Effect.

     (h) The Company will  promptly  notify the holders in the event the Company
discovers or determines that any computer  application  (including  those of its
suppliers,  vendors  and  customers)  that  is  Material  to  its  or any of its
Subsidiaries' business and operations will not be Year 2000 compliant, except to
the extent that such failure could not reasonably be expected to have a Material
Adverse Effect.

     (i) The Company will not and will not permit any  Subsidiary  to enter into
directly or indirectly any transaction or Material group of related transactions
(including  without  limitation  the  purchase,   lease,  sale  or  exchange  of
properties  of any kind or the  rendering  of any  service)  with any  Affiliate
(other than the Company or another  Subsidiary),  except in the ordinary  course
and  pursuant  to  the  reasonable   requirements   of  the  Company's  or  such
Subsidiary's  business  and upon  terms  determined  by the  Company's  Board of
Directors,  in its good faith judgment,  to be fair and reasonable  terms and no
less favorable to the Company or such  Subsidiary  than would be obtainable in a
comparable transaction with a Person not an Affiliate.

     5. CONDITIONS. The obligations of the Purchasers under this Agreement shall
be subject to the condition  that all  representations  and warranties and other
statements  of the Company  herein are true and correct at and as of the closing
of the  purchase  and sale of the  Convertible  Notes,  the  condition  that the
Company shall have performed all of its obligations  hereunder theretofore to be
performed, and the following additional conditions:



                                       8
<PAGE>


     (a)  Counsel  for the  Company  specified  in Annex III  hereto  shall have
furnished to you its written  opinion,  dated the date of such closing,  in form
and substance  satisfactory to each Purchaser,  to the effect set forth in Annex
III hereto.

     (b) On the date of such closing,  the Company shall have  furnished to each
Purchaser such appropriate  further  information,  certificates and documents as
such Purchaser may reasonably request.

     (c) The  representations  and  warranties of the Company in this  Agreement
shall be correct when made and at the time of the Closing.

     (d) The Company shall have  performed and complied with all  agreements and
conditions contained in this Agreement required to be performed or complied with
by it prior to or at the Closing and after  giving  effect to the issue and sale
of the Convertible Notes, no Default or Event of Default shall have occurred and
be continuing.

     (e) The  Company  shall  have  delivered  to each  Purchaser  an  Officer's
Certificate,  dated  the date of the  Closing,  certifying  that the  conditions
specified in Sections 5(c), 5(d) and 5(k) have been fulfilled.

     (f) The  Company  shall have  delivered  to each  Purchaser  a  certificate
certifying  as  to  the  resolutions   attached   thereto  and  other  corporate
proceedings  relating  to  the  authorization,  execution  and  delivery  of the
Convertible Notes and the Agreements.

     (g) On the date of the Closing the  purchase of  Convertible  Notes by each
Purchaser   shall  (i)  be  permitted  by  the  laws  and  regulations  of  each
jurisdiction to which such Purchaser is subject,  without recourse to provisions
(such as Section  1405(a)(8) of the New York Insurance Law)  permitting  limited
investments by insurance  companies  without  restriction as to the character of
the  particular  investment,  (ii) not violate any  applicable law or regulation
(including,  without limitation,  Regulation U, T or X of the Board of Governors
of the Federal  Reserve System) and (iii) not Subject such Purchaser to any tax,
penalty or  liability  under or pursuant to any  applicable  law or  regulation,
which law or  regulation  was not in effect on the date hereof.  If requested by
any  Purchaser,  such  Purchaser  shall have  received an Officer's  Certificate
certifying as to such matters of fact as such Purchaser may  reasonably  specify
to enable such Purchaser to determine whether such purchase is so permitted.

     (h) The Company shall sell the entire  principal  amount of the Convertible
Notes scheduled to be sold at the Closing as specified in Schedule I hereto.

     (i) Without limiting the provisions of Section 6(f), the Company shall have
paid on or  before  the  Closing  the fees,  charges  and  disbursements  of the
Purchasers' special counsel.



                                       9
<PAGE>



     (j) A Private  Placement  number  issued by Standard & Poor's CUSIP Service
Bureau (in  cooperation  with the  Securities  Valuation  Office of the National
Association  of  Insurance  Commissioners)  shall  have  been  obtained  for the
Convertible Notes.

     (k) The Company shall not have changed its jurisdiction of incorporation or
been a party to any merger or consolidation  and shall not have succeeded to all
or any  substantial  part of the  liabilities  of any other entity,  at any time
following  the date of the most  recently  filed  Exchange  Act Report  (defined
below).

     (1) All corporate and other proceedings in connection with the transactions
contemplated  by this  Agreement and all documents and  instruments  incident to
such  transactions  shall be  satisfactory  to each  Purchaser  and its  special
counsel, and each Purchaser and its special counsel shall have received all such
counterpart  originals or  certified  or other copies of such  documents as such
Purchaser or it may reasonably request.

     6. MISCELLANEOUS.

     (a) This  Agreement  shall be binding upon, and inure solely to the benefit
of, the  Purchasers  and the Company and the  respective  successors and assigns
thereof,  and no other person shall acquire or have any right under or by virtue
of this Agreement.  No purchaser of the Convertible Notes from a Purchaser shall
be deemed a successor or assign by reason merely of such purchase.

     (b) Any notice or other  communication  required or  permitted  to be given
hereunder shall be deemed effectively given when personally delivered,  telexed,
transmitted by facsimile or mailed by pre-paid  certified  mail,  return receipt
requested,  or by telephone  when  confirmed in writing by one of the  preceding
methods addressed as follows (as applicable):

     If to the Company, to:

     Celgene Corporation
     7 Powder Horn Drive
     Warren, NJ 07059

     Attention: John W. Jackson
     Telephone Number: (732) 271-1001
     Facsimile Transmission Number: (732) 805-3931

     with a copy to:

     Proskauer Rose LLP
     1585 Broadway
     New York, NY 10036



                                       10
<PAGE>



     Attention: Robert A. Cantone, Esq.
     Telephone Number: (212) 969-3000
     Facsimile Transmission Number: (212) 969-2900

     If to Purchaser:
     at the address and to the Person appearing on Schedule I to this Agreement

     with a copy to:

     Choate, Hall & Stewart
     Exchange Place
     53 State Street
     Boston, MA 02109

     Attention: Frank B. Porter, Jr.
     Telephone Number: (617) 248-5000
     Facsimile Transmission Number: (617) 248-4000

or to such other  address or number and to the attention of such other person as
either party may designate by written notice to the other party. Notice shall be
effective upon actual receipt.

     (c) THIS  AGREEMENT  SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE  WITH
THE LAWS OF THE STATE OF NEW YORK.

     (d) Time shall be of the essence in the performance of this Agreement.

     (e) This  Agreement may be executed by the parties  hereto in any number of
counterparts,  each of which  shall be  deemed to be an  original,  but all such
respective counterparts shall together constitute one and the same instrument.

     (f) Whether or not the  transactions  contemplated  hereby are consummated,
the Company will pay all costs and  expenses  (including  reasonable  attorneys'
fees of a special counsel) incurred by each Purchaser or holder of a Convertible
Note in connection with such transactions and in connection with any amendments,
waivers or consents  under or in respect of this  Agreement  or the  Convertible
Notes  (whether or not such  amendment,  waiver or consent  becomes  effective),
including,  without limitation: (3) the costs and expenses incurred in enforcing
or  defending  (or  determining  whether or how to enforce or defend) any rights
under this Agreement or the  Convertible  Notes or in responding to any subpoena
or other legal  process or informal  investigative  demand  issued in connection
with this Agreement or the Convertible  Notes, or by reason of being a holder of
any  Convertible  Note,  and (b) the costs  and  expenses,  including  financial
advisors' fees,  incurred in connection with the insolvency or bankruptcy of the
Company or any Subsidiary or in connection with any work-out or restructuring of
the


                                       11
<PAGE>



transactions  contemplated hereby and by the Convertible Notes. The Company will
pay, and will save each  Purchaser and each other holder of a  Convertible  Note
harmless from,  all claims in respect of any fees,  costs or expenses if any, of
brokers and finders (other than those retained by you).

     (g)  Anything in this  Agreement or the  Convertible  Notes to the contrary
notwithstanding, any payment of principal of or Make-Whole Amount or interest on
any  Convertible  Note that is due on a date other than a Business  Day shall be
made on the next succeeding  Business Day without  including the additional days
elapsed in the  computation  of the  interest  payable  on such next  succeeding
Business Day.

     (h) This  Agreement  and the  Convertible  Notes  may be  amended,  and the
observance of any term hereof or of the Convertible  Notes may be waived (either
retroactively or prospectively), with (and only with) the written consent of the
Company and each of the holders.

     (i) From time to time hereafter,  the Company will execute and deliver,  or
will cause to be executed and delivered,  such additional agreements,  documents
and instruments and will take all such other actions as any holder or holders of
the Convertible Notes may reasonably request

                                  [END OF PAGE]



                                       12
<PAGE>



for the purpose of implementing or effectuating the provisions contained herein,
in the Convertible Notes or in the Registration Rights Agreement.

                                           Very truly yours,

                                           CELGENE CORPORATION

                                           By: /s/Robert J. Hugin
                                              --------------------------------
                                             Name: Robert J. Hugin
                                             Title: Senior Voice President & CFO

Accepted as of the date hereof:


JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY
By:

By:    /s/ Stephen J. Blewitt
  ---------------------------------------
Name:      Stephen J. Blewitt
     ------------------------------------
Title:     Senior Investment Officer
     ------------------------------------


JOHN HANCOCK VARIABLE LIFE INSURANCE COMPANY
By:

By:    /s/ Stephen J. Blewitt
  ---------------------------------------
Name:      Stephen J. Blewitt
     ------------------------------------
Title:     Senior Investment Officer
     ------------------------------------


By:    /s/ Stephen J. Blewitt
  ---------------------------------------
Name:      Stephen J. Blewitt
     ------------------------------------
Title:     Senior Investment Officer
     ------------------------------------



                                       13
<PAGE>



                                   SCHEDULE I

                   JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY


     $3,500,000 GENERAL ACCOUNT
     $6,000,000 GUARANTEED BENEFIT SUB ACCOUNT
     $200,000 SEPARATE ACCOUNT 12

1.   All payments on account of the  Convertible  Notes or other  obligations in
     accordance with the provisions  thereof shall be made by bank wire transfer
     of immediately  available funds for credit,  not later than 12 noon, Boston
     time, to:

     BankBoston
     ABA No. 011000390
     Boston, Massachusetts 02110
     Account of: John Hancock Mutual Life Insurance  Company
                 Private  Placement Collection Account
     Account Number:  541-55417
     On Order of: Celgene Corporation (PPN: 151020 A@3)
     Celgene Corporation 9.00% Senior Convertible Notes due June 30, 2004

2.   Contemporaneous with the above wire transfer, advice setting forth:

     (1)  the full name,  interest  rate and  maturity  date of the  Convertible
          Notes  or  other  obligations;

     (2)  allocation of payment  between  principal and interest and any special
          payment; and

     (3)  name and address of Bank (or  Trustee)  from which wire  transfer  was
          sent shall be delivered or faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Manager
                Investment Accounting Division, B-3
     Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Manager

                                     1 of 6


<PAGE>


                       Investment Accounting Division, B-3
     Fax: 617-572-0628

4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Bond and Corporate Finance Group, T-57
     Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Investment Law Division, T-50
     Fax: 617-572-9268

6.   All securities shall be registered in the name of: John Hancock Mutual Life
     Insurance Company

7.   Tax I.D. No. 04-1414660


                                     2 of 6


<PAGE>



                   JOHN HANCOCK VARIABLE HFE INSURANCE COMPANY
                                    $300,000

1.   All payments on account of the  Convertible  Notes or other  obligations in
     accordance with the provisions  thereof shall be made by bank wire transfer
     of immediately  available funds for credit,  not later than 12 noon, Boston
     time, to:

     BankBoston
     ABA No. 011000390
     Boston, Massachusetts 02110
     Account of: John Hancock Mutual Life Insurance Company
                 Private Placement Collection Account
     Account Number: 541-55417
     On Order of: Celgene Corporation (PPN: 151020 A@ 3)
     Celgene Corporation 9.00% Senior Convertible Notes due June 30, 2004

2.   Contemporaneous with the above wire transfer, advice setting forth:

     (1)  the full  name,  interest  rate  and maturity date of the Convertible
          Notes or other obligations;

     (2)  allocation  of  payment  between  principal   and   interest  and  any
          special payment; and

     (3)  name and address of Bank (or Trustee) from  which  wire  transfer  was
          sent shall be delivered or faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Manager
                Investment Accounting Division, B-3
     Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Manager
                Investment Accounting Division, B-3
     Fax: 617-572-0628

                                     3 of 6


<PAGE>

4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Bond and Corporate Finance Group, T-57
     Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Investment Law Division, T-50
     Fax: 617-572-9268

6.   All  securities  shall be registered in the name of: John Hancock  Variable
     Life Insurance Company

7.   Tax I.D. No. 04-2664016


                                     4 of 6


<PAGE>


                         HANCOCK MEZZANINE PARTNERS L.P.
                                   $5,000,000

1.   All payments on account of the  Convertible  Notes or other  obligations in
     accordance with the provisions  thereof shall be made by bank wire transfer
     of immediately  available funds for credit,  not later than 12 noon, Boston
     time, to:

          Investors Bank & Trust Company
          Boston, Massachusetts 02110
          ABA No. 011001438
          Account Number: 58215013
          for further credit to Hancock Mezzanine Partners L.P., Account 99274
          On Order of: Celgene Corporation (PPN: 151020 A@ 3)
          Celgene Corporation 9.00% Senior Convertible Notes due June 30, 2004

2.   Contemporaneous with the above wire transfer, advice setting forth:

          (1)  the full  name,  interest  rate  and  maturity  date of the Notes
               or other obligations;

          (2)  allocation  of payment  between  principal  and  interest and any
               special payment; and

          (3)  name and address of bank (or  Trustee)  from which wire  transfer
               was sent shall be delivered or faxed and mailed to:

          John Hancock Mutual Life Insurance Company
          200 Clarendon Street
          Boston, MA 02117
          Attention: Manager Investment Accounting Division, B-3
          Fax: 617-572-0628

3.   All notices with respect to  prepayments,  both scheduled and  unscheduled,
     whether  partial or in full,  and notice of maturity  shall be delivered or
     faxed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Manager
                Investment Accounting Division, B-3
     Fax: 617-572-0628

4.   All other  communications  which  shall  include,  but not be  limited  to,
     financial   statements  and   certificates  of  compliance  with  financial
     covenants, shall be delivered or faxed and mailed to:

                                     5 of 6


<PAGE>


     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
     Attention: Bond and Corporate Finance Group, T-57
     Fax: 617-572-1605

5.   A copy of any  notices  relating  to change in  issuer's  name,  address or
     principal  place of business or  location of  collateral  and a copy of any
     legal opinions shall be delivered or fixed and mailed to:

     John Hancock Mutual Life Insurance Company
     200 Clarendon Street
     Boston, MA 02117
          Attention: Investment Law Division, T-50
          Fax: 617-572-9268

6.   Execution documents shall be executed as follows:

          Hancock Mezzanine Partners L.P.
          By: Hancock Mezzanine Investments LLC, its General Partner
          By: John Hancock Mutual Life Insurance Company. as Investment Manager

          By:
             -------------------------------------
               [authorized John Hancock Officer]

7.   All  securities  shall be  registered  in the name  of:  Hancock  Mezzanine
     Partners L.P.

8.   Tax I.D. No. 04-3428544







                                     6 of 6


<PAGE>

                                    EXHIBIT A


     THIS SECURITY AND THE COMMON STOCK  ISSUABLE UPON ITS  CONVERSION  HAVE NOT
BEEN  REGISTERED  UNDER  THE  U.S.  SECURITIES  ACT OF  1933,  AS  AMENDED  (THE
"SECURITIES  ACT"),  AND  MAY  NOT  BE  OFFERED,   SOLD,  PLEDGED  OR  OTHERWISE
TRANSFERRED  EXCEPT PURSUANT TO AN AVAILABLE  EXEMPTION FROM REGISTRATION  UNDER
THE SECURITIES ACT AND IN ACCORDANCE WITH ALL APPLICABLE  SECURITIES LAWS OF THE
STATES OF THE UNITED STATES AND OTHER JURISDICTIONS.

                               CELGENE CORPORATION

                      9.00% SENIOR CONVERTIBLE NOTE DUE JUNE --, 2004

PPN No.:
No. R-                                                             $
                                                                    ----------

     CELGENE  CORPORATION,  a corporation  duly organized and existing under the
laws of Delaware (the "Company") for value  received,  hereby promises to pay to
or registered  assigns, the principal sum of Dollars ($.   )on June, 2004 and to
pay interest thereon, from , 1999, or from the most recent interest payment date
to which interest has been paid or duly provided for, semi-annually on June ----
and December   in each year, commencing December ---,1999,  at the rate of 9.00%
per  annum,  until the  principal  hereof is due,  and at the rate of 11.00% per
annum on any overdue principal and premium, if any, and, to the extent permitted
by law, on any overdue interest. The interest so payable, and punctually paid or
duly  provided  for, on any interest  payment date will be paid to the person in
whose name this Security (or one or more  predecessor  Securities) is registered
at the close of  business on the regular  record date for such  interest,  which
shall be the June 1 or December 1 (whether or not a Business  Day),  as the case
may be, next  preceding  such interest  payment  date.  Payment of the principal
of(and  premium,  if any, on) this Security  shall be made upon the surrender of
this Security to the Company,  at its office at 7 Powder Horn Drive,  Warren, NJ
07059 (or such other office within the United States as shall be notified by the
Company  to the  holder  hereof)  (the  "Designated  Office"),  in such  coin or
currency  of the United  States of  America  as at the time of payment  shall be
legal tender for the payment of public and private debts,  by transfer to a U.S.
dollar  account  maintained  by the payee  with a bank in the  United  States of
America.  Payment of interest on this Security shall be made by wire transfer to
a U.S.  dollar account  maintained by the payee with a bank in the United States
of  America,  provided  that  if  the  holder  shall  not  have  furnished  wire
instructions in writing to the Company no later than the record date relating to
an interest  payment date,  such payment may be made by U.S. dollar check mailed
to the address of the Person entitled thereto as such address shall appear


<PAGE>


     This Security is one of the Company's  9.00% Senior  Convertible  Notes due
June 30, 2004,  limited to $15,000,000.00  aggregate  principal  amount,  issued
pursuant  to that  certain  Note  Purchase  Agreement  dated  July 6, 1999 (such
agreements,  as amended,  modified and supplemented from time to time, the "Note
Purchase  Agreement") between the Company and the Purchasers named therein,  and
the holder  hereof is entitled to the benefits of the Note  Purchase  Agreement,
and may enforce the  agreements  contained  herein and therein and  exercise the
remedies  provided  for hereby and  thereby or  otherwise  available  in respect
hereof and thereof, all in accordance with the terms hereof and thereof.

     1. Optional Redemption With Premium. This Security is subject to redemption
upon not less than 30 nor more than 60 days'  notice by mail,  at any time on or
after July 6, 2001,  as a whole or in part,  (in any amount  that is an integral
multiple of $1000) at the election of the Company, at a redemption price of 103%
the principal  amount thereof,  together with accrued interest to the redemption
date,  but interest  installments  whose stated  maturity is on or prior to such
redemption  date will be payable to the holder of this Security,  or one or more
predecessor  Securities,  of  record at the close of  business  on the  relevant
record dates referred to on the face hereof; provided, however, that the Company
may not redeem  this  Security  on or prior to July 6, 2002  unless the  Closing
Price of the Common Stock exceeds 225% of the Conversion  Price for each Trading
Day in a period of 20 Consecutive  Trading Days commencing not earlier than July
6, 2001.  The term  "Conversion  Price" on any day shall equal $1,000 divided by
the Conversion Rate in effect on each such day.

     2.  Conversion.  (a) The holder of this Security is entitled at any time on
or after July 6, 2000 and before the close of  business on June 30, 2004 (or, in
case this  Security or a portion  hereof is called for  redemption or the holder
hereof  has  exercised  its right to require  the  Company  to  repurchase  this
Security or a portion  hereof,  then in respect of this Security or such portion
hereof,  as the case may be,  until  and  including,  but  (unless  the  Company
defaults in making the payment due upon  redemption or  repurchase,  as the case
may  be)  not  after,  the  close  of  business  on the  redemption  date or the
Repurchase Date, as the case may be) to convert this Security (or any portion of
the principal amount hereof that is an integral multiple of $1,000),  into fully
paid and nonassessable  shares  (calculated as to each conversion to the nearest
1/100 of a share) of Common  Stock of the Company at the rate of 52.63 shares of
Common  Stock for each $1,000  principal  amount of Security  (or at the current
adjusted rate if an adjustment has been made as provided below) (the "Conversion
Rate") by surrender of this  Security,  duly endorsed or assigned to the Company
or in blank to the  Company at the  Designated  Office,  accompanied  by written
notice to the Company that the holder hereof elects to convert this Security (or
if less than the entire principal  amount hereof is to be converted,  specifying
the  portion  hereof to be  converted).  Upon  surrender  of this  Security  for
conversion,  the holder will be entitled to receive the interest accruing on the
principal amount of this Security then being converted from the interest payment
date next preceding the date of such  conversion to such date of conversion.  No
payment or adjustment  is to be made on  conversion  for dividends on the Common
Stock issued on conversion  hereof. No fractions of shares or scrip representing
fractions of shares will be issued on conversion,  but instead of any fractional
interest, the Company shall pay a cash adjustment,


                                       2

<PAGE>



computed  on the basis of the Closing  Price of the Common  Stock on the date of
conversion,  or, at its option,  the  Company  shall round up to the next higher
whole share.  This Security shall be deemed to have been  converted  immediately
prior to the close of business on the day of surrender hereof for conversion, in
accordance  with the  foregoing  provisions,  and at such time the rights of the
holder  hereof,  as a holder  hereof,  shall  cease,  and the  Person or Persons
entitled to receive the Common Stock issuable on conversion  shall be treated by
all Persons as the holder or holders of such Common Stock at such time. Upon any
partial conversion of this Security, the Company, at its expense, will forthwith
issue and deliver to, or upon the order of the holder hereof,  a new Convertible
Note or Convertible Notes in principal amount equal to the unconverted principal
amount  of such  surrendered  Convertible  Note,  such new  Convertible  Note or
Convertible  Notes  to be  dated  and to bear  interest  from  the date to which
interest has been paid on such surrendered Convertible Note.

     As promptly as possible after the conversion of this Security,  in whole or
in part, and in any event within ten (10) days thereafter,  the Company,  at its
expense,  will issue and deliver a certificate or certificates for the number of
full shares of Common Stock issuable upon such conversion.

     (b) The Conversion  Rate shall be subject to adjustments  from time to time
as follows:

     (1) In case the Company shall pay or make a dividend or other  distribution
on any class of capital stock of the Company  payable in shares of Common Stock,
the  Conversion  Rate in effect at the opening of business on the day  following
the  Determination  Date  for  such  dividend  or  other  distribution  shall be
increased by dividing such  Conversion Rate by a fraction of which the numerator
shall be the  number  of  shares of  Common  Stock  outstanding  at the close of
business on such Determination Date and the denominator shall be the sum of such
number of shares and the total number of shares  constituting  such  dividend or
other  distribution,  such increase to become  effective  immediately  after the
opening of  business  on the day  following  such  Determination  Date.  For the
purposes of this paragraph (1), the number of shares of Common Stock at any time
outstanding  shall not include  shares  held in the  treasury of the Company but
shall include shares issuable in respect of scrip certificates issued in lieu of
fractions  of shares of Common  Stock.  The Company will not pay any dividend or
make any  distribution  on shares of Common  Stock held in the  treasury  of the
Company.

     (2) Subject to the last  sentence of paragraph (7) of this Section 2(b), in
case the Company shall issue rights, options, warrants or convertible securities
entitling  the holders  thereof to  subscribe  for or purchase  shares of Common
Stock at a price  per  share  less  than the  current  market  price  per  share
(determined  as provided in paragraph  (8) of this  Section  2(b)) of the Common
Stock on the Determination  Date for such  distribution,  the Conversion Rate in
effect at the opening of business on the day following such Determination  Date,
shall be increased by dividing such Conversion Rate by a fraction of


                                       3

<PAGE>



which the numerator shall be the number of shares of Common Stock outstanding at
the close of  business on such  Determination  Date plus the number of shares of
Common  Stock  which the  aggregate  amount  received  by the  Company  upon the
issuance of such rights,  options,  warrants or convertible  securities plus the
aggregate  amount  receivable  by the Company upon the exercise or conversion of
such rights, options,  warrants or convertible securities would purchase at such
current market price and the denominator shall be the number of shares of Common
Stock outstanding at the close of business on such  Determination  Date plus the
number of shares of Common Stock so offered for  subscription or purchase,  such
increase to become  effective  immediately  after the opening of business on the
day following such Determination Date provided,  that no such adjustment need to
be made in the case of the  granting by the Company to employees or directors of
the Company or  consultants  to the Company of Common  Stock  and/or  options to
purchase Common Stock and the issuance of Common Stock upon the exercise of such
options.  For the purposes of this paragraph (2), the number of shares of Common
Stock at any time  outstanding  shall not include shares held in the treasury of
the Company but shall include shares  issuable in respect of scrip  certificates
issued in lieu of  fractions  of shares of Common  Stock.  The Company  will not
issue any rights,  options,  warrants or  convertible  securities  in respect of
shares of Common Stock held in the treasury of the Company.

     (3) In case  outstanding  shares of Common  Stock shall each be  subdivided
into a greater number of shares of Common Stock,  the Conversion  Rate in effect
at the  opening  of  business  on the day  following  the day  upon  which  such
subdivision   becomes  effective  shall  be  proportionately   increased,   and,
conversely,  in case  outstanding  shares of Common Stock shall each be combined
into a smaller number of shares of Common Stock,  the Conversion  Rate in effect
at the  opening  of  business  on the day  following  the day  upon  which  such
combination becomes effective shall be proportionately reduced, such increase or
reduction, as the case may be, to become effective immediately after the opening
of  business  on the day  following  the day  upon  which  such  subdivision  or
combination becomes effective.

     (4) Subject to the last  sentence of paragraph (7) of this Section 2(b), in
case the Company shall,  by dividend or otherwise,  distribute  evidences of its
indebtedness, shares of any class of capital stock, or other property (including
securities,  but  excluding  (i) any rights,  options,  warrants or  convertible
security  referred to in paragraph (2) of this Section 2(b) (ii) any dividend or
distribution  paid  exclusively  in cash,  (iii) any  dividend  or  distribution
referred  to in  paragraph  (1) of this  Section  2(b) and (iv)  any  merger  or
consolidation  to which  Section 2(h)  applies),  the  Conversion  Rate shall be
adjusted  so that the same  shall  equal the rate  determined  by  dividing  the
Conversion  Rate in effect  immediately  prior to the close of  business  on the
Determination  Date for such  distribution  by a fraction of which the numerator
shall be the current market price per share (determined as provided in paragraph
(8) of this Section  2(b)) of the Common Stock on such  Determination  Date less
the then  fair  market  value  (as  determined  in good  faith  by the  Board of
Directors of the Company) of the portion of the assets, shares or evidences of


                                        4


<PAGE>


indebtedness  so  distributed  applicable  to one share of Common  Stock and the
denominator  shall be such current  market price per share of the Common  Stock,
such adjustment to become effective immediately prior to the opening of business
on the day following such Determination  Date provided,  that no such adjustment
need be made in the case of an  underwritten  public offering of Common Stock in
which the  shares of  Common  Stock are sold to the  public at a price per share
equal to or in excess of 95% of the market  price per share of the Common  Stock
as of the date of the pricing of such underwritten public offering. If the Board
of Directors  determines the fair market value of any  distribution for purposes
of this  paragraph (4) by reference to the actual or when issued  trading market
for any securities  comprising such  distribution,  it must in doing so consider
the prices in such market over the same  period  used in  computing  the current
market price per share pursuant to paragraph (8) of this Section 2(b).

     (5) In case the  Company  shall,  by  dividend  or  otherwise,  make a Cash
Distribution,  then,  and in each  such  case,  immediately  after  the close of
business on the Determination  Date for such Cash  Distribution,  the Conversion
Rate shall be  adjusted  so that the same  shall  equal the rate  determined  by
dividing  the  Conversion  Rate in  effect  immediately  prior  to the  close of
business on such  Determination  Date by a fraction  (a) the  numerator of which
shall be equal to the current market price per share  (determined as provided in
paragraph  (8) of this Section  2(b)) of the Common Stock on such  Determination
Date  less an  amount  equal to the  quotient  of(l)  the  amount  of such  Cash
Distribution  divided by (2) the number of shares of Common Stock outstanding on
such  Determination  Date and (b) the denominator of which shall be equal to the
current market price per share  (determined as provided in paragraph (8) of this
Section 2(b)) of the Common Stock on such Determination Date.

     (6) In case the  Company or any  Subsidiary  shall make an Excess  Purchase
Payment,  then,  and in each such  case,  immediately  prior to the  opening  of
business  on the day after the tender  offer in  respect  of which  such  Excess
Purchase Payment is to be made expires, the Conversion Rate shall be adjusted so
that the same shall equal the rate determined by dividing the Conversion Rate in
effect  immediately prior to the close of business on the Determination Date for
such tender offer by a fraction (a) the numerator of which shall be equal to the
current market price per share  (determined as provided in paragraph (8) of this
Section  2(b)) of the  Common  Stock on such  Determination  Date less an amount
equal to the  quotient  of (A) the Excess  Purchase  Payment  divided by (B) the
number of shares of Common Stock outstanding  (including any tendered shares) as
of the Determination Date less the number of all shares validly tendered and not
withdrawn as of the Determination Date and (b) the denominator of which shall be
equal to the current market price per share (determined as provided in paragraph
(8) of this Section 2(b)) of the Common Stock as of such Determination Date.

     (7) The  reclassification of Common Stock into securities other than Common
Stock (other than any  reclassification  upon a consolidation or merger to which
Section 2(h)

                                        5


<PAGE>



applies) shall be deemed to involve (a) a distribution of such securities  other
than Common Stock to all holders of Common Stock (and the effective date of such
reclassification  shall  be  deemed  to be the  Determination  Date),  and (b) a
subdivision  or  combination,  as the case may be,  of the  number  of shares of
Common Stock  outstanding  immediately prior to such  reclassification  into the
number of shares of Common Stock  outstanding  immediately  thereafter  (and the
effective  date of such  reclassification  shall be  deemed  to be "the day upon
which  such  subdivision   becomes  effective"  or  "the  day  upon  which  such
combination becomes effective", as the case may be, and "the day upon which such
subdivision or combination  becomes  effective"  within the meaning of paragraph
(3) of this Section 2(b)). Rights,  options,  warrants or convertible securities
issued by the Company entitling the holders thereof to subscribe for or purchase
shares  of  Common  Stock,  which  rights,  options,   warrants  or  convertible
securities  (i) are deemed to be  transferred  with such shares of Common Stock,
(ii) are not  exercisable  and  (iii)  are also  issued  in  respect  of  future
issuances of Common  Stock,  in each case in clauses (i) through (iii) until the
occurrence of a specified event or events ("Trigger Event"),  shall for purposes
of this Section 2(b) not be deemed  issued until the  occurrence of the earliest
Trigger Event.

     (8) Except as otherwise  provided in the last  sentence of this  subsection
(8) of Section 2(b) for the purpose of any  computation  under  paragraphs  (2),
(4),  (5) or (6) of this  Section  2(b) the  current  market  price per share of
Common Stock on any date shall be  calculated by the Company and be deemed to be
the average of the daily  Closing  Prices for the five (5)  consecutive  Trading
Days  selected by the Company  commencing  not more than ten (10)  Trading  Days
before,  and ending not later than,  the earlier of the day in question  and the
day before the "ex date" with respect to the issuance or distribution  requiring
such computation.  For purposes of this paragraph, the term "ex date", when used
with respect to any issuance or distribution,  means the first date on which the
Common Stock trades  regular way in the applicable  securities  market or on the
applicable  securities  exchange  without the fight to receive such  issuance or
distribution.  The current market price with respect to any option issued to any
employee or director of the Company or  consultant  to the Company  shall be the
fair market  value on the date of grant  determined  by  reference to the market
price on the day of the grant of such option or to the market price at the close
of business on the Trading Day immediately preceding such grant.

     (9) No  adjustment  in the  Conversion  Rate shall be required  unless such
adjustment (plus any adjustments not previously made by reason of this paragraph
(9)) would require an increase or decrease of at least one percent in such rate;
provided,  however,  that any adjustments  which by reason of this paragraph (9)
are not  required to be made shall be carried  forward and taken into account in
any subsequent  adjustment.  All calculations under this Section 2 shall be made
to the nearest cent or to the nearest  one-hundredth of a share, as the case may
be.

     (10) The Company may make such  increases in the  Conversion  Rate, for the
remaining  term of the  Securities  or any  shorter  term,  in addition to those
required by

                                        6


<PAGE>



paragraphs  (1), (2), (3), (4), (5) and (6) of this Section 2(b) as it considers
to be  advisable  in order to avoid or diminish any income tax to any holders of
shares of Common Stock  resulting from any dividend or  distribution of stock or
issuance of rights,  options,  warrants or convertible securities to purchase or
subscribe for stock or from any event treated as such for income tax purposes.

     (c) Whenever the  Conversion  Rate is adjusted as provided in Section 2(b),
the Company  shall  compute the  adjusted  Conversion  Rate in  accordance  with
Section 2(b) and shall prepare a certificate (the "Conversion Rate Certificate")
signed by the Senior Financial Officer of the Company setting forth the adjusted
Conversion  Rate and  showing  in  reasonable  detail  the facts upon which such
adjustment is based,  and shall promptly  deliver such certificate to the holder
of this Security. If the holders of the Convertible Notes and the Company cannot
agree in writing as to the adjusted  Conversion  Rate in accordance with Section
2(b), the holders of the  Convertible  Notes and the Company shall determine the
adjusted Conversion Rate in accordance with the following procedure. The holders
of the  Convertible  Notes and the Company  shall each  appoint  one  registered
securities broker,  licensed with the Securities and Exchange Commission to sell
securities  to the  public,  which  broker  shall  be a senior  vice  president,
managing  director or equivalent of a major  securities  brokerage  company with
offices in New York, New York.  Each of such brokers shall have no less than ten
(10) years  experience  in such field,  shall be  unaffiliated  with,  and their
employer securities brokerage company shall be unaffiliated with, the holders of
the Convertible Notes and the Company and shall not have previously participated
in any  underwriting  of the  Company's  Common Stock in any public  offering or
provided any Material  investment  banking or corporate advisory services to the
Company.  The holders of the Convertible  Notes and the Company shall make their
appointments  promptly and, in any event,  within thirty (30) days from the date
of the  Conversion  Rate  Certificate.  The two brokers  shall meet and shall be
instructed  to render a  determination  of the adjusted  Conversion  Rate to the
holders of the  Convertible  Notes and the Company within sixty (60) days of the
date of the Conversion Rate  Certificate.  If the two brokers cannot agree, then
each broker  shall render their  independent  determination  and the two brokers
shall simultaneously  therewith provide the name of a third broker acceptable to
the two brokers meeting the criteria set forth above.  The third broker shall be
instructed  to render a  determination  of the adjusted  Conversion  Rate within
thirty (30) days of his or her appointment.  The two closest  determinations  of
the adjusted Conversion Rate shall be averaged mad shall constitute the adjusted
Conversion  Rate.  If the two  brokers  cannot  agree upon a third  broker,  the
selection of a third broker  shaI1 be  submitted to binding  arbitration  in New
York, New York under the rules of the American Arbitration  Association.  In the
event that the  difference  between the  Company's  calculation  of the adjusted
Conversion Rate and the  calculation of the adjusted  Conversion Rate determined
by the  foregoing  process is five  percent  (5%) or greater  then the costs and
expenses  of the  brokers  and  any  arbitration  shall  be  paid  by and be the
obligation  of the  Company and in the event that such  difference  is less than
five percent (5O/o) the holders of the Convertible Notes (as a group) shall each
pay its pro rata share of 50% of such costs and expenses  and the Company  shall
pay 50% of such costs and expenses.

     (d) In case:


                                        7


<PAGE>



     (1) the  Company  shall  declare a dividend  or other  distribution  on its
Common Stock payable (i) otherwise than  exclusively in cash or (ii) exclusively
in cash in an amount that would require any adjustment pursuant to Section 2(b);
or

     (2) the Company  shall  authorize the granting to the holders of its Common
Stock of rights, options, warrants or convertible securities to subscribe for or
purchase any shares of capital stock of any class or of any other rights; or

     (3) of any  reclassification  of the Common Stock of the Company, or of any
consolidation,  merger or share exchange to which the Company is a party and for
which  approval  of any  shareholders  of the  Company  is  required,  or of the
conveyance, sale, transfer or lease of all or substantially all of the assets of
the Company; or

     (4) of the voluntary or involuntary dissolution,  liquidation or winding up
of the Company; or

     (5) the Company or any Subsidiary  shall commence a tender offer for all or
a portion of the  Company's  outstanding  shares of Common Stock (or shall amend
any such tender offer);

then the Company shall cause to be delivered to the holder of this Security,  at
least 20 days (or 10 days in any case  specified  in  clause  (1) or (2)  above)
prior  to the  applicable  record,  expiration  or  effective  date  hereinafter
specified,  a notice  stating  (x) the date on which a record is to be taken for
the  purpose  of such  dividend,  distribution,  rights,  options,  warrants  or
convertible  securities or, if a record is not to be taken, the date as of which
the  holders  of  Common  Stock  of  record  to be  entitled  to such  dividend,
distribution,  rights,  options,  warrants or  convertible  securities are to be
determined,  (y) the date on which the right to make  tenders  under such tender
offer  expires  or (z) the date on which such  reclassification,  consolidation,
merger,  share  exchange,   conveyance,   transfer,  sale,  lease,  dissolution,
liquidation  or winding up is expected to become  effective,  and the dale as 0f
which it is expected that holders of Common Stock of record shall be entitled to
exchange  their shares of Common Stock for  securities,  cash or other  property
deliverable upon such reclassification,  consolidation,  merger, share exchange,
conveyance,  transfer,  sale,  lease,  dissolution,  liquidation  or winding up.
Neither the failure to give such notice nor any defect  therein shall affect the
legality or validity of the proceedings  described in clauses (1) through (5) of
this Section 2(d).

     (e) The Company  shall at all times reserve and keep  available,  free from
preemptive  rights,  out of its  authorized but unissued  Common Stock,  for the
purpose of effecting the  conversion of the Security,  the full number of shares
of Common Stock then issuable upon the conversion of this Security.

                                        8


<PAGE>



     (f) Except as provided in the next  sentence,  the Company will pay any and
all taxes and duties  that may be payable in respect of the issue or delivery of
shares of Common Stock on  conversion of this  Security.  The Company shall not,
however,  be  required to pay any tax or duty which may be payable in respect of
any  transfer  involved in the issue and delivery of shares of Common Stock in a
name  other  than that of the  holder  of this  Security,  and no such  issue or
delivery  shall be made  unless and until the Person  requesting  such issue has
paid to the Company the amount of any such tax or duty,  or has  established  to
the satisfaction of the Company that such tax or duty has been paid.

     (g) The  Company  agrees  that all  shares  of  Common  Stock  which may be
delivered upon  conversion of the Security,  upon such delivery,  will have been
duly authorized and validly issued and will be fully paid and nonassessable (and
shall be issued out of the Company's  authorized but unissued Common Stock) and,
except as provided in the second  sentence of Section  2(0, the Company will pay
all taxes, liens and charges with respect to the issue thereof.

     (h) In case of any consolidation of the Company with any other Person,  any
merger of the Company into another  Person or of another Person into the Company
(other than a merger which does not result in any reclassification,  conversion,
exchange or cancellation  of outstanding  shares of Common Stock of the Company)
or any conveyance,  sale,  transfer or lease of all or substantially  all of the
properties and assets of the Company, the Person formed by such consolidation or
resulting from such merger or which acquires such properties and assets,  as the
case may be,  shall  execute  and  deliver  to the  holder  of this  Security  a
supplemental  agreement  providing  that such  holder has the right,  during the
period this  Security  shall be  convertible  as specified in Section  2(a),  to
convert  this  Security  only into the kind and amount of  securities,  cash and
other property receivable upon such  consolidation,  merger,  conveyance,  sale,
transfer or lease  (including  any Common Stock  retainable)  by a holder of the
number of shares of Common Stock of the Company into which this  Security  might
have been converted immediately prior to such consolidation, merger, conveyance,
sale, transfer or lease, assuming such holder of Common Stock of the Company (i)
is not a Person  with which the  Company  consolidated,  into which the  Company
merged or which  merged  into the  Company  or to which such  conveyance,  sale,
transfer or lease was made, as the case may be (a "Constituent  Person"),  or an
Affiliate  of a  Constituent  Person and (ii) failed to  exercise  its fights of
election,  if any,  as to the kind or  amount  of  securities,  cash  and  other
property receivable upon such consolidation,  merger, conveyance, sale, transfer
or lease  (provided  that if the kind or  amount of  securities,  cash and other
property receivable upon such consolidation, merger, conveyance, sale, transfer,
or lease is not the same for each  share of  Common  Stock of the  Company  held
immediately prior to such consolidation,  merger, conveyance,  sale, transfer or
lease by others  than a  Constituent  Person or an  Affiliate  of a  Constituent
Person  and in  respect of which  such  fights of  election  shall not have been
exercised  ("Non-electing Share"), then for the purpose of this Section 2(h) the
kind and amount of  securities,  cash and other  property  receivable  upon such
consolidation,  merger,  conveyance,  sale,  transfer or lease by the holders of
each Non-electing  Share shall be deemed to be the kind and amount so receivable
per  share  by a  plurality  of  the  Non-electing  Shares).  Such  supplemental
agreement  shall provide for  adjustments  which,  for events  subsequent to the
effective date of such


                                       9

<PAGE>



supplemental  agreement,  shall be as nearly equivalent as may be practicable to
the  adjustments  provided for in this Section 2. The above  provisions  of this
Section  2(h)  shall  similarly  apply to  successive  consolidations,  mergers,
conveyances,  sales, transfers or leases. In this paragraph,  "securities of the
kind receivable" upon such consolidation,  merger, conveyance, transfer, sale or
lease by a holder of Common Stock means securities that, among other things, are
registered  and freely  transferable  under the  Securities  Act, and listed and
approved  for  quotation  in all  securities  markets,  in each case to the same
extent as such securities so receivable by a holder of Common Stock.

     (i) The  Company  (i) will effect all  registrations  with,  and obtain all
approvals  by, all  governmental  authorities  that may be  necessary  under any
United States Federal or state law  (including the Securities  Act, the Exchange
Act arid  state  securities  and Blue Sky laws) for the  shares of Common  Stock
issuable upon conversion of this Security to be lawfully issued and delivered as
provided  herein,  and  thereafter  publicly  traded (if  permissible  under the
Securities Act) and qualified or listed as contemplated by clause (ii) (it being
understood  that the Company  shall not be required to register the Common Stock
issuable on conversion  hereof under the Securities  Act, except pursuant to the
Registration Rights Agreement between the Company and the initial holder of this
Security);  and (ii) will list the shares of Common Stock  required to be issued
and delivered upon conversion of Securities, prior to such issuance or delivery,
on each national securities exchange on which outstanding Common Stock is listed
or  quoted  at the time of such  delivery,  or if the  Common  Stock is not then
listed On any securities exchange,  to qualify the Common Stock for quotation on
the Nasdaq National Market or such other inter-dealer  quotation system, if any,
on which the Common Stock is then quoted.

     (j) For purposes  hereof:  (references  to Sections  shall mean Sections of
this Security unless otherwise specified)

     "Affiliate"  of any  specified  Person means any other  Person  directly or
indirectly  controlling  or  controlled  by or under  direct or indirect  common
control  with  such  specified  Person.  For the  purposes  of this  definition,
"control",  when used with respect to any specified  Person,  means the power to
direct the  management  and  policies of such  Person,  directly or  indirectly,
whether  through the ownership of voting  securities,  by contract or otherwise;
and the terms  "controlling" and "controlled"  have meanings  correlative to the
foregoing.

     "Business  Day" means any day other than a Saturday,  a Sunday or other day
which shall be in Boston, Massachusetts or New York, New York or a legal holiday
or a day on which  commercial  banks in Boston,  Massachusetts  or New York, New
York are required or authorized to be closed.

     "Cash Distribution" means the distribution by the Company to holders of its
Common Stock of cash,  other than any cash that is distributed  upon a merger or
consolidation  to  which  Section  2(h)  applies  or as part  of a  distribution
referred to in paragraph (4) of Section 2(b).

                                       10


<PAGE>



     "Change of Control" is defined in Section 3(0(2).

     "Closing" is defined in Section 1 of the Note Purchase Agreement.

     "Closing Price" means, with respect to the Common Stock of the Company, for
any day, the reported last sale price per share on the Nasdaq  National  Market,
or, if the Common  Stock is not  admitted  to  trading  on the  Nasdaq  National
Market, on the principal national securities exchange or inter-dealer  quotation
system on which the Common  Stock is listed or admitted  to  trading,  or if not
admitted  to trading on the Nasdaq  National  Market,  or listed or  admitted to
trading on any national  securities  exchange or inter-dealer  quotation system,
the   average  of  the   closing   bid  and  asked   prices  per  share  in  the
over-the-counter  market as furnished by any New York Stock Exchange member firm
selected from time to time by the Company for that purpose.

     "Code"  means the Internal  Revenue  Code of 1986,  as amended from time to
time, and the rules and regulations promulgated thereunder from time to time.

     "Common  Stock" means the Common  Stock,  par value $.01 per share,  of the
Company  authorized  at the  date of this  instrument  as  originally  executed.
Subject to the  provisions  of Section  2(h),  shares  issuable on conversion or
repurchase of this Security  shall include only shares of Common Stock or shares
of any class or classes of common stock resulting from any  reclassification  or
reclassifications thereof; provided, however, that if at any time there shall be
more than one such resulting class, the shares so issuable on conversion of this
Security shall include  shares of all such classes,  and the shares of each such
class then so issuable shall be  substantially in the proportion which the total
number of shares of such class resulting from all such  reclassifications  bears
to the  total  number  of shares  of all such  classes  resulting  from all such
reclassifications.

     "Convertible  Note(s)"shall  mean one or more of the Company's 9.00% Senior
Convertible Notes due June ---, 2004.

     "Conversion Price" is defined in Section 1.

     "Conversion Rate" is defined in Section 2(a).

     "Default"  means an event or condition the occurrence or existence of which
would,  with the lapse of time or the giving of notice or both,  become an Event
of Default.

     "Designated Office" is defined in the Preamble.

     "Determination   Date"   means,   in  the  case  of  a  dividend  or  other
distribution, including the issuance of rights, options, warrants or convertible
securities, to the date fixed for the determination of those entitled to receive
such dividend or other distribution, and in the case of a tender offer, the last
time that tenders could have been made pursuant to such tender offer.

                                       11


<PAGE>



     "Environmental  Laws" means any and all Federal,  state, local, and foreign
statutes,  laws, regulations,  ordinances,  rules,  judgments,  orders, decrees,
permits,  licenses,  written  agreements  or written  governmental  restrictions
relating to pollution and the  protection of the  environment  or the release of
any materials into the  environment,  including but not limited to those related
to hazardous  substances or wastes,  air  emissions  and  discharges to waste or
public systems.

     "ERISA"  means the Employee  Retirement  Income  Security  Act of 1974,  as
amended from time to time, and the rules and regulations  promulgated thereunder
from time to time in effect.

     "ERISA Affiliate" means any trade or business (whether or not incorporated)
that is treated as a single employer together with the Company under section 414
of the Code.

     "Excess Purchase  Payment" means the product of (A) the excess,  if any, of
(i) the amount of cash plus the fair market value (as  determined  in good faith
by the Company's Board of Directors) of any non-cash  consideration  required to
be paid with respect to one share of Common Stock  acquired or to be acquired in
a tender offer made by the Company or any  Subsidiary  of the Company for all or
any portion of the Common Stock over (ii) the current  market price per share as
of the last time that tenders could have been made pursuant to such tender offer
and (B) the  number of  shares  validly  tendered  and not  withdrawn  as of the
Determination Date in respect of such tender offer.

     "Event of Default" is defined in the preamble to Section 4.

     "Exchange Act" shall mean the Securities  Exchange Act of 1934, as amended,
or  any  successor  Federal  statute,  and  the  rules  and  regulations  of the
Securities and Exchange Commission promulgated thereunder, all as the same shall
be in effect from time to time.

     "GAAP" means  generally  accepted  accounting  principles as in effect from
time to time in the United States of America.

     "Hazardous  Materials"  means any and all  pollutants,  toxic or  hazardous
wastes or any other substances that might pose a hazard to health or safety, the
remediation of which may be required or the generation,  manufacture,  refining,
production, processing, treatment, storage, handling, transportation,  transfer,
use, disposal, release, discharge,  spillage, seepage, or filtration of which is
restricted,   prohibited  or  penalized  by  any  applicable  Environmental  Law
(including, without limitation,  asbestos, urea formaldehyde foam insulation and
polychlorinated biphenyls).

     "holder"  means,  with  respect to this  Security or any other  Convertible
Note,  the Person in whose name it is registered  in the register  maintained by
the Company pursuant to Section 6(d).

                                       12


<PAGE>



     "Lien"  means,  with respect to any Person,  any  mortgage,  lien,  pledge,
charge, security interest or other encumbrance,  or any interest or title of any
vendor,  lessor,  lender or other  secured  party to or of such Person under any
conditional sale or other title retention agreement or Capital Lease (as defined
by  GAAP),  upon or  with  respect  to any  property  or  asset  of such  Person
(including in the case of stock, stockholder agreements, voting trust agreements
and all similar arrangements).

     "Make-Whole Amount" is defined in Section 4(g).

     "Material" means material in relation to the business, operations, affairs,
financial  condition,  assets,  properties,  or prospects of the Company and its
Subsidiaries taken as a whole.

     "Material  Adverse  Effect"  means a  material  adverse  effect  on (a) the
business,  operations,  affairs,  financial  condition,  assets,  properties  or
prospects  of the  Company  and its  Subsidiaries  taken as a whole,  or (b) the
ability of the  Company  to  perform  its  obligations  under the Note  Purchase
Agreement,  the Registration  Rights Agreement and the Convertible Notes, or (c)
the validity or enforceability of this Agreement or the Convertible Notes.

     "Multiemployer Plan" means any Plan that is a "multiemployer plan" (as such
term is defined in section 4001(a)(3) of ERISA).

     "Note Purchase Agreement" is defined in the Preamble.

     "PBGC"  means the  Pension  Benefit  Guaranty  Corporation  referred to and
defined in ERISA or any successor thereto.

     "Person" means an individual,  partnership,  corporation, limited liability
company,  association,  trust, unincorporated  organization,  or a government or
agency or political subdivision thereof.

     "Plan"  means an  "employee  benefit  plan" (as defined in section  3(3) of
ERISA) that is or,  within the preceding  five years,  has been  established  or
maintained,  or to which  contributions are or, within the preceding five years,
have been made or required to be made, by the Company or any ERISA  Affiliate or
with respect to which the Company or any ERISA Affiliate may have any liability.

     "Purchaser(s)"  JOHN HANCOCK  MUTUAL LIFE INSURANCE  COMPANY;  JOHN HANCOCK
VARIABLE LIFE INSURANCE COMPANY and HANCOCK MEZZANINE PARTNERS

     "Registration  Rights  Agreement" means the  Registration  Rights Agreement
dated as of the date hereof among the Purchasers and the Company.


                                       13


<PAGE>



     "Repurchase Date" is defined in Section 3(a).

     "Repurchase Price" is defined in Section 3(a).

     "Responsible  Officer"  means any Senior  Financial  Officer  and any other
senior officer of the Company with  responsibility for the administration of the
relevant covenants in this Security or in the Note Purchase Agreement.

     "Securities Act" shall mean the Securities Act of 1933, as amended,  or any
successor  Federal statute,  and the rules and regulations of the Securities and
Exchange Commission promulgated  thereunder,  all as the same shall be in effect
from time to time.

     "Senior  Financial  Officer" means the chief financial  officer,  principal
accounting officer, treasurer or comptroller of the Company.

     "Subsidiary" means, as to any Person, any corporation, association or other
business entity in which such Person or one or more of its  Subsidiaries or such
Person  and one or more of its  Subsidiaries  owns  sufficient  equity or voting
interests  to  enable  it or them (as a group)  ordinarily,  in the  absence  of
contingencies,  to elect a majority  of the  directors  (or  Persons  performing
similar  functions) of such entity, and any partnership or joint venture if more
than a 50% interest in the profits or capital thereof is owned by such Person or
one or  more  of its  Subsidiaries  or  such  Person  and  one  or  more  of its
Subsidiaries  (unless  such  partnership  can and  does  ordinarily  take  major
business actions without the prior approval of such Person or one or more of its
Subsidiaries). Unless the context otherwise clearly requires, any reference to a
"Subsidiary" is a reference to a Subsidiary of the Company.

     "Trading  Day" means (i) if the Common  Stock is admitted to trading on the
Nasdaq  National  Market  or any  other  system of  automated  dissemination  of
quotations of securities  prices,  a day on which trades may be effected through
such  system;  (ii) if the Common Stock is listed or admitted for trading on the
New York Stock  Exchange or any other  national  securities  exchange,  a day on
which such  exchange is open for  business;  or (iii) if the Common Stock is not
admitted  to trading on the Nasdaq  National  Market or listed or  admitted  for
trading on any  national  securities  exchange or any other  system of automated
dissemination of quotation of securities prices, a day on which the Common Stock
is traded regular way in the over-the-counter market and for which a closing bid
and a closing asked price for the Common Stock are available.

     3. Right to Require  Repurchase.  (a) In the event that a Change in Control
shall  occur,  then the holder of this  Security  shall have the right,  at such
holder's option, to require the Company to repurchase,  and upon the exercise of
such fight the Company shall  repurchase,  this Security,  or any portion of the
principal  amount  hereof  that is  equal to  $1,000  or any  integral  multiple
thereof,  on the date (the  "Repurchase  Date") that is thirty (30) Trading Days
after the date on which the Company  gives notice  thereof to the holder of this
Security,  at a purchase  price  equal to 100% of the  principal  amount of this
Security to be repurchased plus interest accrued to

                                       14


<PAGE>



the  Repurchase  Date  (the  "Repurchase  Price");   provided,   however,   that
installments  of interest on this Security whose stated  maturity is on or prior
to the Repurchase  Date shall be payable to the holder of this Security,  or one
or more predecessor  Securities,  registered as such on the relevant Record Date
according to their terms. At the option of the Company, the Repurchase Price may
be paid in cash or subject to the  fulfillment  by the Company of the conditions
set forth in each of Section 5 and Section 6 and subject to the  limitations set
forth in each of Section 5 and Section 6, by delivery of shares of Common  Stock
or in common  stock of any Person  which  succeeds  the  Company up to a maximum
amount often  percent (10%) of the then issued and  outstanding  Common Stock or
common stock of such Person following any Change in Control, provided,  however,
the cash plus the fair market  value of such shares  shall equal the  Repurchase
Price.  The  Company  agrees to give the holder of this  Security  notice of any
Change in Control, by facsimile  transmission  confirmed in writing by overnight
courier  service,  promptly  and in any event within two (2) Trading Days of the
occurrence thereof.

     (b) To exercise a repurchase right, the holder shall deliver to the Company
on or before the 10th Trading Day prior to the  Repurchase  Date,  together with
this  Security,  written  notice of the holder's  exercise of such right,  which
notice  shall set forth the name of the  holder,  the number of shares of Common
Stock then owned by such holder and its affiliates, the principal amount of this
Security to be repurchased  (and, if this Security is to be repurchased in part,
the portion of the principal  amount thereof to be  repurchased  and the name of
the  person in which  the  portion  thereof  to remain  outstanding  after  such
repurchase is to be registered) and a statement that an election to exercise the
repurchase  right is being made  thereby  and, in the event that the  Repurchase
Price shall be paid in whole or in part by the  delivery of shares,  as provided
above,  the name or names  (and the  addresses)  in which the  certificates  for
shares shall be issued.  Such written notice shall be  irrevocable,  except that
the fight of the holder to convert  this  Security  (or the portion  hereof with
respect to which the repurchase  right is being  exercised) shall continue until
the close of business on the  Repurchase  Date (or if the Company  elects to pay
the Repurchase Price by delivery of shares as provided above, until the close of
business on the Trading Day  immediately  preceding the first delivery of shares
with respect thereto).

     (c) In the event a repurchase  right shall be exercised in accordance  with
the terms  hereof,  the Company  shall pay or cause to be paid to the holder the
Repurchase Price in cash or shares, as provided above, together with accrued and
unpaid interest to the Repurchase Date; provided,  however, that installments of
interest  that  mature on or prior to the  Repurchase  Date  shall be payable in
cash, to the holders of this Security,  or one or more  predecessor  Securities,
registered as such at the close of business on the relevant regular record date.

     (d) If this Security (or portion thereof) is surrendered for repurchase and
is not so paid on or prior to the Repurchase  Date, the principal amount of this
Security (or such portion  hereof,  as the case may be) shall,  until paid, bear
interest to the extent  permitted by applicable law from the Repurchase  Date at
eleven percent (11%) per annum,  and shall remain  convertible into Common Stock
until the  principal of this Security (or portion  thereof,  as the case may be)
shall have been paid or duly provided for.


                                       15


<PAGE>



     (e) If this  Security  is to be  repurchased  only in  part,  it  shall  be
surrendered  to the Company at the  Designated  Office (with,  if the Company so
requires,  due  endorsement  by, or a written  instrument  of  transfer  in form
satisfactory  to the Company duly executed by, the holder hereof or his attorney
duly  authorized in writing),  and the Company shall execute and make  available
for delivery to the holder without service charge, a new Security or Securities,
containing identical terms and conditions, each in an authorized denomination in
aggregate  principal  amount  equal  to and in  exchange  for the  unrepurchased
portion of the principal of the Security so surrendered.

     (f) For purposes of this Section 3.

     (1) the term "beneficial owner" shall be determined in accordance with Rule
13d-3  promulgated  by the Securities  and Exchange  Commission  pursuant to the
Exchange Act; and

     (2) a "Change in  Control"  shall be deemed to have  occurred  at the time,
after the original issuance of this Security, of:

     (i) the  acquisition  by any Person of  beneficial  ownership,  directly or
indirectly,  through a  purchase,  merger or other  acquisition  transaction  or
series of transactions, of shares of capital stock of the Company entitling such
Person  to  exercise  50% or more of the  total  voting  power of all  shares of
capital  stock of the Company  entitled  to vote  generally  in the  election of
directors  (any shares of voting  stock of which such  Person is the  beneficial
owner that are not then  outstanding  being deemed  outstanding  for purposes of
calculating such  percentage)  other than any such acquisition by the Company or
any employee benefit plan of the Company; or

     (ii) any  consolidation  or merger of the Company  with or into,  any other
Person,  any  merger  of  another  Person  with  or  into  the  Company,  or any
conveyance,  transfer,  sale, lease or other disposition of all or substantially
all of the  assets of the  Company to another  Person  (other  than (a) any such
transaction  (x)  which  does not  result in any  reclassification,  conversion,
exchange or cancellation of outstanding  shares of Common Stock and (y) pursuant
to which holders of Common Stock  immediately prior to such transaction have the
entitlement to exercise, directly or indirectly, 50% or more of the total voting
power of all shares of capital stock  entitled to vote generally in the election
of  directors  of the  continuing  or surviving  Person  immediately  after such
transaction  and  (b)  any  merger  which  is  effected  solely  to  change  the
jurisdiction of incorporation of the Company and results in a  reclassification,
conversion or exchange of outstanding  shares of Common Stock into solely shares
of common stock,

     4. Events of Default.  (a) "Event of Default",  wherever used herein, means
any one of the following  events  (whatever the reason for such Event of Default
and whether it shall be voluntary or  involuntary or be effected by operation of
law or pursuant to any judgment,

                                       16


<PAGE>



decree  or  order  of  any  court  or  any  order,  rule  or  regulation  of any
administrative or governmental body):

     (1) (A) default in the payment of any  principal or premium,  if any,  upon
this Security when the same becomes due and payable, whether at maturity or at a
date fixed for  prepayment or by  declaration or otherwise or (B) default in the
payment of any interest upon this Security when it becomes due and payable,  and
continuance of such default for a period of five (5) days; or

     (2) default by the Company in the performance of its obligations in respect
of any  conversion of this Security (or any portion  hereof) in accordance  with
Section 2; or

     (3)  failure  by the  Company  to give any  notice of a Change  of  Control
required to be delivered in accordance with Section 3(a); or

     (4) default in the  performance,  or breach,  of any  material  covenant or
warranty  of the  Company  herein,  in the Note  Purchase  Agreement,  or in the
Registration  Rights  Agreements (other than a covenant or warranty a default in
the performance or breach of which is specifically  dealt with elsewhere in this
Section 4(a)) and  continuance of such default or breach for a period of 30 days
after the  earlier to occur  of(A) the  Company's  obtaining  knowledge  of such
default or (B) the Company's receiving written notice specifying such default or
breach and requiring it to be remedied and stating that such notice is a "Notice
of Default" hereunder; or

     (5) any  representation  or warranty made in writing by or on behalf of the
Company or by any  officer  of the  Company  furnished  in  connection  with the
transactions  contemplated  hereby proves to have been false or incorrect in any
material respect on the date as of which made; or

     (6) a final  judgment or judgments for the payment of money  aggregating in
excess of  $250,000  are  rendered  against  one or more of the  Company and its
Subsidiaries  and which  judgments are not,  within 60 days after entry thereof,
bonded,  discharged or stayed pending  appeal,  or are not discharged  within 60
days after the expiration of such stay; or

     (7) a  default  under  any  bond,  debenture,  note or  other  evidence  of
indebtedness  for  money  borrowed  by the  Company,  or  under  any  agreement,
mortgage,  indenture or  instrument  under which there may be issued or by which
there may be secured or evidenced  any  indebtedness  for money  borrowed by the
Company,  with a principal  amount  then  outstanding  in excess of  $1,000,000,
whether  such  indebtedness  now exists or shall  hereafter  be  created,  which
default shall constitute a failure to pay the principal of such indebtedness (in
whole or in any part greater than $1,000,000) when due and payable or shall have
resulted in such  indebtedness (in whole or in any part greater than $1,000,000)
becoming or being  declared due and payable  prior to the date on which it would
otherwise have become due and payable; or

                                       17


<PAGE>



     (8) if (i) any Plan other than a  Multiemployer  Plan shall fail to satisfy
the  minimum  funding  standards  of ERISA or the Code for any plan year or part
thereof or a waiver of such standards or extension of any amortization period is
sought or  granted  under  section  412 of the Code,  (ii) a notice of intent to
terminate  any Plan  other  than a  Multiemployer  Plan  shall  have  been or is
reasonably  expected to be filed with the PBGC or the PBGC shall have instituted
proceedings  under  ERISA  section  4042 to  terminate  or  appoint a trustee to
administer  any Plan  other  than a  Multiemployer  Plan or the PBGC  shall have
notified  the  Company  or  any  ERISA  Affiliate  that  a  Plan  other  than  a
Multiemployer  Plan may  become a  subject  of any such  proceedings,  (iii) the
aggregate  "amount of  unfunded  benefit  liabilities"  (within  the  meaning of
section  4001(a)(18) of ERISA) under all Plans other than a Multiemployer  Plan,
determined in accordance with Title IV of ERISA, shall exceed $250,000, (iv) the
Company or any ERISA Affiliate shall have incurred or is reasonably  expected to
incur any liability  pursuant to Title I or IV of ERISA or the penalty or excise
tax provisions of the Code relating to employee  benefit plans,  (v) the Company
or any  ERISA  Affiliate  withdraws  from any  Multiemployer  Plan,  or (vi) the
Company or any  Subsidiary  establishes or amends any employee  welfare  benefit
plan that  provides  post-employment  welfare  benefits  in a manner  that would
increase the liability of the Company or any Subsidiary thereunder; and any such
event or events described in clauses (i) through (vi) above, either individually
or together with any other such event or events, could reasonably be expected to
have a Material  Adverse  Effect.  (As used in this Section  4(a)(8),  the terms
"employee  benefit  plan" and  "employee  welfare  benefit  plan" shall have the
respective meanings assigned to such terms in Section 3 of ERISA.); or

     (9) if, as a result of any Change of Control or any other  consolidation or
merger,  the holding by the Purchasers or any assignees thereof of this Security
or the holding of any Common Stock or common stock of any Person  succeeding the
Company,  issued to the Purchasers or any assignees  thereof after conversion of
this  Security  would  constitute,  with  respect  to  any  Plan  (other  than a
Multiemployer   Plan)  a  prohibited   transaction   which  would   violate  the
prohibitions  of section 406 of ERISA or which would  subject any  "disqualified
person"  (as  defined in section  4975(e)(2)  of the Code) to a tax  pursuant to
section 4975 (c)(1)(A)-(D) of the Code; or

     (10) the entry by a court  having  jurisdiction  in the  premises  of (A) a
decree or order for relief in respect of the Company in an  involuntary  case or
proceeding  under  any  applicable  Federal  or  State  bankruptcy,  insolvency,
reorganization  or other  similar  law or (B) a decree  or order  adjudging  the
Company a bankrupt or  insolvent,  or  approving  as  properly  filed a petition
seeking reorganization,  arrangement, adjustment or composition of or in respect
of the  Company  under any  applicable  Federal or State law,  or  appointing  a
custodian,  receiver,  liquidator,  assignee,  trustee,  sequestrator  or  other
similar official of the Company or of any substantial  part of its property,  or
ordering the winding up or  liquidation of its affairs,  and the  continuance of
any such decree or order for relief or any such other  decree or order  unstayed
and in effect for a period of 60 consecutive days; or

                                       18


<PAGE>



          (11) the commencement by the Company of a voluntary case or proceeding
     under   any   applicable   Federal   or   State   bankruptcy,   insolvency,
     reorganization  or other  similar law or of any other case or proceeding to
     be  adjudicated a bankrupt or insolvent,  or the consent by it to the entry
     of a decree or order for relief in respect of the Company in an involuntary
     case or  proceeding  under  any  applicable  Federal  or State  bankruptcy,
     insolvency,  reorganization  or other similar law or to the commencement of
     any bankruptcy or insolvency  case or proceeding  against it, or the filing
     by it of a petition or answer or consent seeking  reorganization or similar
     relief under any  applicable  Federal or State law, or the consent by it to
     the filing of such petition or to the  appointment of or taking  possession
     by a custodian,  receiver,  liquidator,  assignee, trustee, sequestrator or
     other  similar  official of the Company or of any  substantial  part of its
     property,  or  the  making  by it of  an  assignment  for  the  benefit  of
     creditors,  or not paying its debts as they become due or the  admission by
     it in writing of its  inability  to pay its debts  generally as they become
     due, or the taking of corporate action by the Company in furtherance of any
     such action.

     (b) If an Event of Default  (other  than an Event of Default  specified  in
Section 4(a)(10) or 4(a)(11)) occurs and is continuing,  then in every such case
the holder of this  Security  may  declare  the  principal  hereof to be due and
payable  immediately,  by a notice in writing to the Company,  and upon any such
declaration  such  principal  and  all  accrued  interest  hereon  shall  become
immediately due and payable without presentment, demand, protest or other notice
of any kind,  all of which are hereby  expressly  waived,  and the Company shall
forthwith upon any such  acceleration pay to the holder of this Security (i) the
entire principal of and interest accrued on this Security, and (ii) in addition,
to the extent  permitted  by  applicable  law, an amount equal to the Make Whole
Amount,  as  liquidated  damages  and  not as a  penalty;  and,  in  case of the
occurrence  of an Event of Default of the  character  described in  subdivisions
4(a)(10) or 4(a)(11)  the  principal of and accrued  interest on this  Security,
ipso facto shall become  immediately  due and payable without any declaration or
other act of the  holder  of this  Security  and  without  presentment,  demand,
protest or other notice of any kind, all of which are hereby  expressly  waived,
and the Company shall forthwith upon any such  acceleration pay to the holder of
this Security (x) the entire  principal of and interest accrued on this Security
and (y) in addition,  if such Event of Default is  "Voluntary"  (as  hereinafter
defined),  to the extent  permitted  by  applicable  law, an amount equal to the
Make-Whole Amount, as liquidated damages and not as a penalty.

     For  purposes  of this  section  4(a),  "Voluntary"  shall mean an Event of
Default of the character  described in  subdivisions  4(a)(10) or 4(a)(11) which
shall  have  been  (x)  procured  by  the  Company  or  any  officer,  director,
stockholder or Affiliate of the Company or (y) primarily the result of action or
inaction by the Company or by any officer, director, stockholder or Affiliate of
the Company.

     (c) In case any one or more of the Events of Default  specified  in section
4(a) shall have occurred,  and  irrespective of whether this Security has become
or has been declared  immediately due and payable under section 4(a), the holder
of this Security may proceed to protect and enforce its rights either by suit in
equity or by action at law, or both. The Company stipulates that the remedies at
law of the holder of this  Security  in the event of any  Default or  threatened
Default by the Company in the  performance of or compliance with any covenant or
agreement in

                                       19


<PAGE>



this Security,  the Note Purchase Agreement or the Registration Rights Agreement
are not and will not be adequate and that,  to the fullest  extent  permitted by
law,  such  terms may be  specifically  enforced  by a decree  for the  specific
performance  thereof,  whether by an injunction  against a violation  thereof or
otherwise.

     (d) No remedy  conferred in this Security,  the Note Purchase  Agreement or
the  Registration  Rights  Agreement  is intended to be  exclusive  of any other
remedy,  and each and every  such  remedy  shall be  cumulative  and shall be in
addition to every other remedy given hereunder or thereunder or now or hereafter
existing at law or in equity or by statute or otherwise.

     (e) No course of dealing  between the Company and any of its  Subsidiaries,
on the one hand,  and the holder of this  Security,  on the other  hand,  and no
delay by any such holder in  exercising  any rights  hereunder or under the Note
Purchase  Agreement or the  Registration  Rights  Agreement  shall  operate as a
waiver of any rights of such holder.

     (f) In case any one or more of the Events of Default  specified  in section
4(a) shall have occurred, all amounts to be applied to the prepayment or payment
of this  Security  shall be applied,  after the payment of all related costs and
expenses incurred by the holder of this Security (including, without limitation,
compensation  to  any  and  all  trustees,  liquidators,  receivers  or  similar
officials and reasonable  fees,  expenses and  disbursements of counsel) in such
order of priority as is determined by the holder of this Security.

     (g) The term "Make-Whole  Amount" means, with respect to this Security,  an
amount equal to the excess,  if any, of the  Discounted  Value of the  Remaining
Scheduled  Payments  with respect to the Called  Principal of this Security over
the amount of such Called Principal,  provided that the Make-Whole Amount may in
no event be less than zero.  For the  purposes  of  determining  the  Make-Whole
Amount, the following terms have the following meanings:

     "Called  Principal" means, with respect to this Security,  the principal of
this Security that has become or is declared to be  immediately  due and payable
pursuant to Section 4(b).

     "Discounted  Value"  means,  with  respect to the Called  Principal of this
Security,  the amount obtained by discounting all Remaining  Scheduled  Payments
with respect to such Called Principal from their respective  scheduled due dates
to the Settlement Date with respect to such Called Principal, in accordance with
accepted  financial  practice  and at a  discount  factor  (applied  on the same
periodic  basis as that on which  interest on this Security is payable) equal to
the Reinvestment Yield with respect to such Called Principal.

     "Reinvestment  Yield" means,  with respect to the Called  Principal of this
Security,  150 basis points over the yield to maturity implied by (i) the yields
reported,  as of 10:00  A.M.  (New York City time) on the  second  Business  Day
preceding  the  Settlement  Date with respect to such Called  Principal,  on the
display designated as "PX-I" of the Bloomberg  Financial Markets Services Screen
for actively  traded U.S.  Treasury  securities  having a maturity  equal to the
Remaining Average Life of such Called Principal as of such

                                       20


<PAGE>



Settlement  Date, or (ii) if such yields are not reported as of such time or the
yields  reported as of such time are not  ascertainable,  the Treasury  Constant
Maturity Series Yields  reported,  for the latest day for which such yields have
been so reported as of the second  Business Day  preceding the  Settlement  Date
with respect to such Called Principal, in Federal Reserve Statistical Release H.
15 (519) (or any  comparable  successor  publication)  for actively  traded U.S.
Treasury  securities  having a constant  maturity equal to the Remaining Average
Life of such Called  Principal as of such  Settlement  Date.  Such implied yield
will  be  determined,  if  necessary,  by  (a)  converting  U.S.  Treasury  bill
quotations  to  bond-equivalent  yields in accordance  with  accepted  financial
practice and (b)  interpolating  linearly  between (1) the actively  traded U.S.
Treasury  security  with the duration  closest to and greater than the Remaining
Average  Life  and (2) the  actively  traded  U.S.  Treasury  security  with the
duration closest to and less than the Remaining Average Life.

     "Remaining  Average Life" means, with respect to any Called Principal,  the
number  of years  (calculated  to the  nearest  one-twelfth  year)  obtained  by
dividing (i) such Called Principal into (ii) the sum of the products obtained by
multiplying (a) the principal component of each Remaining Scheduled Payment with
respect to such Called  Principal by (b) the number of years  (calculated to the
nearest  one-twelfth  year) that will elapse  between the  Settlement  Date with
respect to such Called  Principal and the  scheduled due date of such  Remaining
Scheduled Payment.

     "Remaining  Scheduled  Payment" means, with respect to the Called Principal
of this  Security,  all payments of such Called  Principal and interest  thereon
that  would be due  after  the  Settlement  Date  with  respect  to such  Called
Principal  if no  payment  of such  Called  Principal  were  made  prior  to its
scheduled due date, provided that if such Settlement Date is not a date on which
interest payments are due to be made under the terms of this Security,  then the
amount of the next succeeding  scheduled interest payment will be reduced by the
amount of interest accrued to such Settlement Date.

     "Settlement  Date"  means,  with  respect to the Called  Principal  of this
Security,  the date on which such Called  Principal or has become or is declared
to be immediately due and payable pursuant to Section 4(b).

     5.  Consolidation,  Merger, Etc. (a) The Company shall not consolidate with
or merge into any other Person or,  directly or  indirectly,  convey,  transfer,
sell or lease  all or  substantially  all of its  properties  and  assets to any
Person, and the Company shall not permit any Person to consolidate with or merge
into the Company or, directly or indirectly, convey, transfer, sell or lease all
or substantially all of its properties and assets to the Company, unless:

     (1) in case the Company shall consolidate with or merge into another Person
or convey,  transfer,  sell or lease all or substantially  all of its properties
and assets to any Person,  the Person formed by such consolidation or into which
the Company is merged or the Person which  acquires by  conveyance,  transfer or
sale, or which leases, all or substantially all the properties and assets of the
Company shall be a corporation, limited

                                       21


<PAGE>



liability company, partnership or trust, shall be organized and validly existing
under  the laws of the  United  States of  America,  any  State  thereof  or the
District of Columbia and shall expressly  assume,  by an agreement  supplemental
hereto,  executed  and  delivered  to  the  holder  of  this  Security  in  form
satisfactory to the holder, the due and punctual payment of the principal of(and
premium, if any) and interest on this Security and the performance or observance
of every covenant of this Security on the part of the Company to be performed or
observed,   including  the  conversion   rights  provided  herein  (which  shall
thereafter  relate  to common  stock of such  successor,  on a basis  reasonably
designed to preserve the economic  value to the holder of this  Security of such
conversion rights);

     (2)  immediately  after giving effect to such  transaction and treating any
indebtedness  which  becomes an obligation of the Company or a Subsidiary of the
Company as a result of such  transaction  as having been incurred by the Company
or such Subsidiary of the Company at the time of such  transaction,  no Event of
Default, and no event which, after notice or lapse of time or both, would become
an Event of Default, shall have happened and be continuing;

     (3) the Company has  delivered to the holder of this  Security an officers'
certificate stating that such consolidation,  merger, conveyance, transfer, sale
or lease and, if a  supplemental  agreement is required in connection  with such
transaction,  such supplemental agreement, comply with this Section and that all
conditions  precedent herein provided for relating to such transaction have been
complied with; and

     (4) counsel for the Company has delivered to the holder of this Security an
opinion of such counsel with respect to such consolidation,  merger, conveyance,
transfer,  sale  or  lease,  and if a  supplemental  agreement  is  required  in
connection with such  transaction,  such supplemental  agreement,  which opinion
shall be, in form and  substance,  reasonably  acceptable to such holder and its
counsel.

     (b) Upon any  consolidation  of the Company  with, or merger of the Company
into,  any other  Person or any  conveyance,  transfer,  sale or lease of all or
substantially all of the properties and assets of the Company in accordance with
Section 5(a), the successor  Person formed by such  consolidation  or into which
the Company is merged or to which such  conveyance,  transfer,  sale or lease is
made shall succeed to, and be substituted  for, and may exercise every right and
power of,  the  Company  under  this  Security  with the same  effect as if such
successor Person had been named as the Company herein, and thereafter, except in
the case of a lease, the predecessor Person shall be relieved of all obligations
and covenants under this Security.

     6.  Payment in Stock.  (a) The  Company may elect to pay some or all of the
Repurchase Price by delivery of shares of Common Stock or shares of common stock
in any Person  succeeding  the  Company,  if and only if, each of the  following
conditions shall be satisfied  (without limiting any other conditions  contained
herein):

     (1) Any such payment shall be made in five equal  installments,  on each of
the five consecutive  Trading Days ending on and including the third Trading Day
immediately preceding

                                       22


<PAGE>



the date when any cash payment would  otherwise be due, and the shares of Common
Stock or common  stock of any  Person  succeeding  the  Company  deliverable  in
payment of each such  installment  shall have a fair market value as of the date
of such  installment  of not less  than 20% of the  amount of such  payment  due
hereunder  which is payable in shares of stock.  For purposes of this Section 6,
the fair  market  value of shares of Common  Stock  shall be equal to 95% of the
Closing Price for the immediately preceding Trading Day;

     (2) In the event any shares of Common  Stock or common  stock of any Person
succeeding  the  Company to be issued in  respect  of any  amount due  hereunder
require  registration under any Federal securities law before such shares may be
freely transferable without being subject to any transfer restrictions under the
Securities  Act of  1933  upon  issuance,  such  registration  shall  have  been
completed  and shall have become  effective  prior to the date of the first such
installment;

     (3) In the event any shares of Common  Stock or common  stock of any Person
succeeding  the  Company to be issued in  respect  of any  amount due  hereunder
require  registration  with or approval of any governmental  authority under any
State law or any other  Federal law before such shares may be validly  issued or
delivered upon issuance or transferred freely, such registration shall have been
completed or have become  effective and such approval  shall have been obtained,
in each case, prior to the date of the first such installment;

     (4) The shares of Common Stock or common stock of any Person succeeding the
Company  deliverable  in payment of such  amount due  hereunder  shall have been
approved for quotation in the Nasdaq  National Market  immediately  prior to the
date of the first such installment or, if at the time its shares of Common Stock
or shares of common  stock of any Person  succeeding  the  Company are listed or
admitted for trading on any national securities  exchange,  the shares of Common
Stock or common stock in any Person succeeding the Company and deliverable shall
have been so listed or admitted for trading.

     (5) All shares of Common Stock or common stock of any Person succeeding the
Company  deliverable in payment of such amount due hereunder shall,  upon issue,
be duly and  validly  issued and fully paid and  non-assessable  and free of any
preemptive rights;

     (6) In respect of each such payment date,  the Company shall have given the
holder of this  Security not less than 10 nor more than 15 Trading  Days' notice
of its election to effect payment in respect of such payment date by delivery of
shares of Common  Stock;  provided  that any such  notice  shall  accompany  the
Company's notice of a Change of Control relating thereto; and

     (7) The Company shall deliver,  or cause to be delivered a certificate from
the Person succeeding the Company which states,  that after giving effect to any
Change of Control that the holding by the Purchasers or any assignees thereof of
this Security,  or the holding of any Common Stock or common stock of any Person
succeeding the Company after  conversion of this Security would not constitute a
prohibited transaction which would violate the prohibition of

                                       23


<PAGE>



section  406 of ERISA or which  would  subject  any  "disqualified  person"  (as
defined in section  4975(e)(2)  of the Code) to a tax  pursuant to section  4975
(c)(1)(A)-(D) of the Code.

     If all of the  conditions  set forth in this Section 6(a) are not satisfied
in accordance with the terms hereof, any such amount due hereunder shall be paid
by the Company only in cash.

     (b) Any issuance of shares of Common Stock or shares of common stock of any
Person  succeeding  the  Company  in respect of any  installment  due  hereunder
pursuant  to this  Section 6 shall be deemed to have been  effected  immediately
prior to the close of business on the date of delivery of such  installment  and
the person or persons in whose name or names any certificate or certificates for
shares of Common Stock shall be issuable upon such  delivery  shall be deemed to
have  become  on such  date the  holder  or  holders  of  record  of the  shares
represented thereby;  provided,  however,  that in case any installment shall be
due on a date when the stock transfer books of the Company shall be closed,  the
person or persons in whose name or names the  certificate  or  certificates  for
such shares are to be issued shall be deemed to have become the record holder or
holders  thereof  for all  purposes  at the  opening  of  business  on the  next
succeeding  day on which  such  stock  transfer  books are open.  No  payment or
adjustment  shall be made for  dividends  or  distributions  on any Common Stock
issued pursuant to this Section 6 declared prior to the relevant  delivery date;
and

     (c) Any issuance and delivery of certificates for shares of common stock or
shares of common  stock of any Person  succeeding  the Company  pursuant to this
Section 6 shall be made without  charge to the holder of this  Security for such
certificates  or for any tax or duty in respect of the  issuance  or delivery of
such certificates or the securities represented thereby.

     7.  Other.  (a) No  provision  of this  Security  shall alter or impair the
obligation  of the  Company,  which is absolute  and  unconditional,  to pay the
principal  of,  premium,  if any, and  interest on this  Security in cash at the
times,  places and rate,  and in the coin or currency,  herein  prescribed or to
convert this Security as herein provided.

     (b) The Company will give prompt  written  notice to the holder of Security
of any change in the location of the Designated Office.

     (c) The transfer of this Security is registrable  on the Security  Register
of the Company upon surrender of this Security for  registration  of transfer at
the Designated Office,  duly endorsed by, or accompanied by a written instrument
of transfer in form  satisfactory  to the Company  duly  executed by, the holder
hereof or his attorney duly authorized in writing, and thereupon one or more new
Securities,  of authorized  denominations  and for the same aggregate  principal
amount,  will be  issued  to the  designated  transferee  or  transferees.  Such
Securities are issuable only in registered form without coupons in denominations
of $1,000 and any integral multiple thereof. No service charge shall be made for
any such registration of transfer,  but the Company may require payment of a sum
sufficient to recover any tax or other governmental charge payable in connection
therewith.  Prior to due  presentation  of this  Security  for  registration  of
transfer, the Company and any agent of the Company may treat the Person in whose
name this

                                       24


<PAGE>


Security is registered  as the owner  thereof for all  purposes,  whether or not
this  Security be  overdue,  and neither the Company nor any such agent shall be
affected by notice to the contrary.

     (d) The  Company  shall keep at the  Designated  Office a register  for the
registration  and  registration of transfers of Convertible  Notes. The name and
address of each holder of one or more Convertible  Notes,  each transfer thereof
and the name and address of each  transferee  of one or more  Convertible  Notes
shall be registered in such register.  Prior to due presentment for registration
of transfer,  the Person in whose name any Convertible  Note shall be registered
shall be deemed and  treated as the owner and holder  thereof  for all  purposes
hereof,  and the Company shall not be affected by any notice or knowledge to the
contrary.  The Company shall give to any holder of a  Convertible  Note promptly
upon request therefor, a complete and correct copy of the names and addresses of
all registered holders of Convertible Notes.

     (e) Upon surrender of any  Convertible  Note at the  Designated  Office for
registration  of  transfer  or  exchange  (and in the  case of a  surrender  for
registration of transfer,  duly endorsed or accompanied by a written  instrument
of transfer duly executed by the registered  holder of such  Convertible Note or
his  attorney  duly  authorized  in writing and  accompanied  by the address for
notices  of each  transferee  of such  Convertible  Note or part  thereof),  the
Company shall execute and deliver,  at the Company's expense (except as provided
below),  one or more new Convertible  Notes (as requested by the holder thereof)
in exchange  therefor,  in an  aggregate  principal  amount  equal to the unpaid
principal amount of the surrendered  Convertible Note. Each such new Convertible
Note shall be payable to such  Person as such  holder may  request  and shall be
substantially in the form of this Security. Each such new Convertible Note shall
be dated and bear interest from the date to which  interest shall have been paid
on the  surrendered  Convertible  Note or  dated  the  date  of the  surrendered
Convertible  Note if no interest  shall have been paid thereon.  The Company may
require  payment  of a sum  sufficient  to cover any  stamp tax or  governmental
charge  imposed in respect of any such  transfer of this  Security.  Convertible
Notes shall not be transferred in denominations of less than $100,000,  provided
that if  necessary  to enable the  registration  of  transfer by a holder of its
entire  holding  of  Convertible  Notes,  one  Convertible  Note  may  be  in  a
denomination  of less than  $100,000.  Any  transferee,  by its  acceptance of a
Convertible  Note registered in its name (or the name of its nominee),  shall be
deemed  to have  made the  representation  set  forth in  Section  3 of the Note
Purchase Agreement.

     (f) Upon receipt by the Company of evidence  reasonably  satisfactory to it
of the  ownership of and the loss,  theft,  destruction  or  mutilation  of this
Security  (which evidence shall be notice from such holder of such ownership and
such loss, theft, destruction or mutilation), and

     (i) in the case of loss,  theft or  destruction,  of  indemnity  reasonably
satisfactory  to it  (provided  that if the holder of this  Security is, or is a
nominee for, an original holder or another institutional investor holder of this
Security,  such Person's own unsecured agreement of indemnity shall be deemed to
be satisfactory), or

     (ii) in the case of mutilation, upon surrender and cancellation thereof,


                                       25


<PAGE>



the Company at its own expense shall execute and deliver, in lieu thereof, a new
Convertible  Note.  dated and bearing  interest from the date to which  interest
shall have been paid on such lost,  stolen.  destroyed or mutilated  Convertible
Note or dated the date of such lost, stolen,  destroyed or mutilated Convertible
Note if no interest shall have been paid thereon.

     (G) THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE
LAWS OF THE STATE OF NEW YORK, UNITED STATES OF AMERICA.

     (h) So long as you or your  nominee  shall be holder of this  Security  and
notwithstanding  anything in this Security to the contrary, the Company will pay
all sums becoming due hereunder for principal,  Make-Whole  Amount,  if any, and
interest by the method and at the address  specified for such purpose below your
name in  Schedule I of the Note  Purchase  Agreement,  or by such  other  method
provided in the Preamble or at such other address as you shall have from time to
time  specified  to the  Company  in  writing  for  such  purpose,  without  the
presentation  or  surrender  of this  Security,  or the  making of any  notation
hereon,  except that upon written request of the Company made  concurrently with
or  reasonably  promptly  after  payment  in full of this  Security,  you  shall
surrender  this Security for  cancellation,  reasonably  promptly after any such
request to the  Company  at its  principal  executive  office or at the place of
payment most  recently  designated  by the  Company.  Prior to any sale or other
disposition of this Security you will, at your election,  either endorse thereon
the amount of  principal  paid  thereon and the last date to which  interest has
been paid  thereon or surrender  this  Security to the Company in exchange for a
new Convertible  Note pursuant to the terms hereof.  The Company will afford the
benefits of this  Section to any  institutional  investor  that is the direct or
indirect transferee of this Security.

                     [END OF PAGE - SIGNATURE PAGE FOLLOWS]


                                       26


<PAGE>



     1N WITNESS  WHEREOF,  the  Company  has  caused  this  Security  to be duly
executed under its corporate seal.

Dated:          ,1999
                                                     CELGENE CORPORATION


                                                     By:
                                                        ----------------------
                                                        Name:
                                                        Title:
Attest:


- -----------------------------------
Name:
Title:




                                       27



                                                                   EXHIBIT 10.26

     THIS SECURITY AND THE COMMON STOCK  ISSUABLE UPON ITS  CONVERSION  HAVE NOT
BEEN  REGISTERED  UNDER  THE  U.S.  SECURITIES  ACT OF  1933,  AS  AMENDED  (THE
"SECURITIES  ACT"),  AND  MAY  NOT  BE  OFFERED,   SOLD,  PLEDGED  OR  OTHERWISE
TRANSFERRED  EXCEPT PURSUANT TO AN AVAILABLE  EXEMPTION FROM REGISTRATION  UNDER
THE SECURITIES ACT AND IN ACCORDANCE WITH ALL APPLICABLE  SECURITIES LAWS OF THE
STATES OF THE UNITED STATES AND OTHER JURISDICTIONS.

                               CELGENE CORPORATION

                 9.00% SENIOR CONVERTIBLE NOTE DUE JUNE 30, 2004

PPN No.: 151020 A@ 3                                                  $3,500,000
No. R-1                                                             July 6, 1999

     CELGENE  CORPORATION,  a corporation  duly organized and existing under the
laws of Delaware (the "Company") for value  received,  hereby promises to pay to
John Hancock Mutual Life Insurance Company, or registered assigns, the principal
sum of Three Million Five Hundred Thousand Dollars ($3,500,000) on June 30, 2004
and to pay interest thereon, from July 6, 1999, or from the most recent interest
payment date to which interest has been paid or duly provided for, semi-annually
on June 30 and December 31 in each year,  commencing  December 31, 1999,  at the
rate of 9.00% per annum,  until the principal  hereof is due, and at the rate of
11.00% per annum on any  overdue  principal  and  premium,  if any,  and, to the
extent permitted by law, on any overdue interest.  The interest so payable,  and
punctually paid or duly provided for, on any interest  payment date will be paid
to  the  person  in  whose  name  this  Security  (or  one or  more  predecessor
Securities)  is registered  at the close of business on the regular  record date
for such  interest,  which  shall be the June 1 or  December 1 (whether or not a
Business Day), as the case may be, next  preceding  such interest  payment date.
Payment of the  principal of (and premium,  if any, on) this  Security  shall be
made upon the  surrender  of this  Security to the  Company,  at its office at 7
Powder  Horn Drive,  Warren,  NJ 07059 (or such other  office  within the United
States  as  shall  be  notified  by the  Company  to  the  holder  hereof)  (the
"Designated  Office"),  in such coin or currency of the United States of America
as at the time of payment  shall be legal  tender for the  payment of public and
private debts, by transfer to a U.S. dollar account maintained by the payee with
a bank in the United  States of America.  Payment of  interest on this  Security
shall be made by wire transfer to a U.S. dollar account  maintained by the payee
with a bank in the United  States of America,  provided that if the holder shall
not have furnished wire instructions in writing to the Company no later than the
record date relating to an interest  payment  date,  such payment may be made by
U.S. dollar check mailed to the address of the Person  entitled  thereto as such
address shall appear in the Company security  register.  This Security will rank
pari passu with all existing and future senior debt of the Company.


<PAGE>



     This Security is one of the Company's  9.00% Senior  Convertible  Notes due
June 30, 2004,  limited to $15,000,000.00  aggregate  principal  amount,  issued
pursuant  to that  certain  Note  Purchase  Agreement  dated  July 6, 1999 (such
agreements,  as amended,  modified and supplemented from time to time, the "Note
Purchase  Agreement") between the Company and the Purchasers named therein,  and
the holder  hereof is entitled to the benefits of the Note  Purchase  Agreement,
and may enforce the  agreements  contained  herein and therein and  exercise the
remedies  provided  for hereby and  thereby or  otherwise  available  in respect
hereof and thereof, all in accordance with the terms hereof and thereof.

     1. Optional Redemption With Premium. This Security is subject to redemption
upon not less than 30 nor more than 60 days'  notice by mail,  at any time on or
after July 6, 2001,  as a whole or in part,  (in any amount  that is an integral
multiple of $1000) at the election of the Company, at a redemption price of 103%
the principal  amount thereof,  together with accrued interest to the redemption
date,  but interest  installments  whose stated  maturity is on or prior to such
redemption  date will be payable to the holder of this Security,  or one or more
predecessor  Securities,  of  record at the close of  business  on the  relevant
record dates referred to on the face hereof; provided, however, that the Company
may not redeem  this  Security  on or prior to July 6, 2002  unless the  Closing
Price of the Common Stock exceeds 225% of the Conversion  Price for each Trading
Day in a period of 20 Consecutive  Trading Days commencing not earlier than July
6, 2001.  The term  "Conversion  Price" on any day shall equal $1,000 divided by
the Conversion Rate in effect on each such day.

     2.  Conversion.  (a) The holder of this Security is entitled at any time on
or after July 6, 2000 and before the close of  business on June 30, 2004 (or, in
case this  Security or a portion  hereof is called for  redemption or the holder
hereof  has  exercised  its fight to require  the  Company  to  repurchase  this
Security or a portion  hereof,  then in respect of this Security or such portion
hereof,  as the case may be,  until  and  including,  but  (unless  the  Company
defaults in making the payment due upon  redemption or  repurchase,  as the case
may  be)  not  after,  the  close  of  business  on the  redemption  date or the
Repurchase Date, as the case may be) to convert this Security (or any portion of
the principal amount hereof that is an integral multiple of $1,000),  into fully
paid and nonassessable  shares  (calculated as to each conversion to the nearest
1/100 of a share) of Common  Stock of the Company at the rate of 52.63 shares of
Common  Stock for each $1,000  principal  amount of Security  (or at the current
adjusted rate if an adjustment has been made as provided below) (the "Conversion
Rate") by surrender of this  Security,  duly endorsed or assigned to the Company
or in blank to the  Company at the  Designated  Office,  accompanied  by written
notice to the Company that the holder hereof elects to convert this Security (or
if less than the entire principal  amount hereof is to be converted,  specifying
the  portion  hereof to be  converted).  Upon  surrender  of this  Security  for
conversion,  the holder will be entitled to receive the interest accruing on the
principal amount of this Security then being converted from the interest payment
date next preceding the date of such  conversion to such date of conversion.  No
payment or adjustment  is to be made on  conversion  for dividends on the Common
Stock issued on conversion  hereof. No fractions of shares or scrip representing
fractions of shares will be issued on conversion,  but instead of any fractional
interest, the Company shall pay a cash adjustment,

                                        2


<PAGE>



computed  on the basis of the Closing  Price of the Common  Stock on the date of
conversion,  or, at its option,  the  Company  shall round up to the next higher
whole share.  This Security shall be deemed to have been  converted  immediately
prior to the close of business on the day of surrender hereof for conversion, in
accordance  with the  foregoing  provisions,  and at such time the rights of the
holder  hereof,  as a holder  hereof,  shall  cease,  and the  Person or Persons
entitled to receive the Common Stock issuable on conversion  shall be treated by
all Persons as the holder or holders of such Common Stock at such time. Upon any
partial conversion of this Security, the Company, at its expense, will forthwith
issue and deliver to, or upon the order of the holder hereof,  a new Convertible
Note or Convertible Notes in principal amount equal to the unconverted principal
amount  of such  surrendered  Convertible  Note,  such new  Convertible  Note or
Convertible  Notes  to be  dated  and to bear  interest  from  the date to which
interest has been paid on such surrendered Convertible Note.

     As promptly as possible after the conversion of this Security,  in whole or
in part, and in any event within ten (10) days thereafter,  the Company,  at its
expense,  will issue and deliver a certificate or certificates for the number of
full shares of Common Stock issuable upon such conversion.

     (b) The Conversion  Rate shall be subject to adjustments  from time to time
as follows:

     (1) In case the Company shall pay or make a dividend or other  distribution
on any class of capital stock of the Company  payable in shares of Common Stock,
the  Conversion  Rate in effect at the opening of business on the day  following
the  Determination  Date  for  such  dividend  or  other  distribution  shall be
increased by dividing such  Conversion Rate by a fraction of which the numerator
shall be the  number  of  shares of  Common  Stock  outstanding  at the close of
business on such Determination Date and the denominator shall be the sum of such
number of shares and the total number of shares  constituting  such  dividend or
other  distribution,  such increase to become  effective  immediately  after the
opening of  business  on the day  following  such  Determination  Date.  For the
purposes of this paragraph (1), the number of shares of Common Stock at any time
outstanding  shall not include  shares  held in the  treasury of the Company but
shall include shares issuable in respect of scrip certificates issued in lieu of
fractions  of shares of Common  Stock.  The Company will not pay any dividend or
make any  distribution  on shares of Common  Stock held in the  treasury  of the
Company.

     (2) Subject to the last  sentence of paragraph (7) of this Section 2(b), in
case the Company shall issue rights, options, warrants or convertible securities
entitling  the holders  thereof to  subscribe  for or purchase  shares of Common
Stock at a price  per  share  less  than the  current  market  price  per  share
(determined  as provided in paragraph  (8) of this  Section  2(o)) of the Common
Stock on the Determination  Date for such  distribution,  the Conversion Rate in
effect at the opening of business on the day following such Determination  Date,
shall be increased by dividing such Conversion Rate by a fraction of

                                        3


<PAGE>



which the numerator shall be the number of shares of Common Stock outstanding at
the close of  business on such  Determination  Date plus the number of shares of
Common  Stock  which the  aggregate  amount  received  by the  Company  upon the
issuance of such rights,  options,  warrants or convertible  securities plus the
aggregate  amount  receivable  by the Company upon the exercise or conversion of
such rights, options,  warrants or convertible securities would purchase at such
current market price and the denominator shall be the number of shares of Common
Stock outstanding at the close of business on such  Determination  Date plus the
number of shares of Common Stock so offered for  subscription or purchase,  such
increase to become  effective  immediately  after the opening of business on the
day following such Determination Date provided,  that no such adjustment need to
be made in the case of the  granting by the Company to employees or directors of
the Company or  consultants  to the Company of Common  Stock  and/or  options to
purchase Common Stock and the issuance of Common Stock upon the exercise of such
options.  For the purposes of this paragraph (2), the number of shares of Common
Stock at any time  outstanding  shall not include shares held in the treasury of
the Company but shall include shares  issuable in respect of scrip  certificates
issued in lieu of  fractions  of shares of Common  Stock.  The Company  will not
issue any rights,  options,  warrants or  convertible  securities  in respect of
shares of Common Stock held in the treasury of the Company.

     (3) In case  outstanding  shares of Common  Stock shall each be  subdivided
into a greater number of shares of Common Stock,  the Conversion  Rate in effect
at the  opening  of  business  on the day  following  the day  upon  which  such
subdivision   becomes  effective  shall  be  proportionately   increased,   and,
conversely,  in case  outstanding  shares of Common Stock shall each be combined
into a smaller number of shares of Common Stock,  the Conversion  Rate in effect
at the  opening  of  business  on the day  following  the day  upon  which  such
combination becomes effective shall be proportionately reduced, such increase or
reduction, as the case may be, to become effective immediately after the opening
of  business  on the day  following  the day  upon  which  such  subdivision  or
combination becomes effective.

     (4) Subject to the last  sentence of paragraph (7) of this Section 2(b), in
case the Company shall,  by dividend or otherwise,  distribute  evidences of its
indebtedness, shares of any class of capital stock, or other property (including
securities,  but  excluding  (i) any rights,  options,  warrants or  convertible
security  referred to in paragraph (2) of this Section 2(b) (ii) any dividend or
distribution  paid  exclusively  in cash,  (iii) any  dividend  or  distribution
referred  to in  paragraph  (1) of this  Section  2(b) and (iv)  any  merger  or
consolidation  to which  Section 2(h)  applies),  the  Conversion  Rate shall be
adjusted  so that the same  shall  equal the rate  determined  by  dividing  the
Conversion  Rate in effect  immediately  prior to the close of  business  on the
Determination  Date for such  distribution  by a fraction of which the numerator
shall be the current market price per share (determined as provided in paragraph
(8) of this Section  2(b)) of the Common Stock on such  Determination  Date less
the then  fair  market  value  (as  determined  in good  faith  by the  Board of
Directors of the Company) of the portion of the assets, shares or evidences of

                                        4


<PAGE>



indebtedness  so  distributed  applicable  to one share of Common  Stock and the
denominator  shall be such current  market price per share of the Common  Stock,
such adjustment to become effective immediately prior to the opening of business
on the day following such Determination  Date provided,  that no such adjustment
need be made in the case of an  underwritten  public offering of Common Stock in
which the  shares of  Common  Stock are sold to the  public at a price per share
equal to or in excess of 95% of the market  price per share of the Common  Stock
as of the date of the pricing of such underwritten public offering. If the Board
of Directors  determines the fair market value of any  distribution for purposes
of this  paragraph (4) by reference to the actual or when issued  trading market
for any securities  comprising such  distribution,  it must in doing so consider
the prices in such market over the same  period  used in  computing  the current
market price per share pursuant to paragraph (8) of this Section 2(b).

     (5) In case the  Company  shall,  by  dividend  or  otherwise,  make a Cash
Distribution,  then,  and in each  such  case,  immediately  after  the close of
business on the Determination  Date for such Cash  Distribution,  the Conversion
Rate shall be  adjusted  so that the same  shall  equal the rate  determined  by
dividing  the  Conversion  Rate in  effect  immediately  prior  to the  close of
business on such  Determination  Date by a fraction  (a) the  numerator of which
shall be equal to the current market price per share  (determined as provided in
paragraph  (8) of this Section  2(b)) of the Common Stock on such  Determination
Date  less an  amount  equal to the  quotient  of(l)  the  amount  of such  Cash
Distribution  divided by (2) the number of shares of Common Stock outstanding on
such  Determination  Date and (b) the denominator of which shall be equal to the
current market price per share  (determined as provided in paragraph (8) of this
Section 2(b)) of the Common Stock on such Determination Date.

     (6) In case the  Company or any  Subsidiary  shall make an Excess  Purchase
Payment,  then,  and in each such  case,  immediately  prior to the  opening  of
business  on the day after the tender  offer in  respect  of which  such  Excess
Purchase Payment is to be made expires, the Conversion Rate shall be adjusted so
that the same shall equal the rate determined by dividing the Conversion Rate in
effect  immediately prior to the close of business on the Determination Date for
such tender offer by a fraction (a) the numerator of which shall be equal to the
current market price per share  (determined as provided in paragraph (8) of this
Section  2(b)) of the  Common  Stock on such  Determination  Date less an amount
equal to the  quotient  of (A) the Excess  Purchase  Payment  divided by (B) the
number of shares of Common Stock outstanding  (including any tendered shares) as
of the Determination Date less the number of all shares validly tendered and not
withdrawn as of the Determination  Date and (b)the denominator of which shall be
equal to the current market price per share (determined as provided in paragraph
(8) of this Section 2(b)) of the Common Stock as of such Determination Date.

     (7) The  reclassification of Common Stock into securities other than Common
Stock (other than any  reclassification  upon a consolidation or merger to which
Section 2(h)

                                        5


<PAGE>



applies) shall be deemed to involve (a) a distribution of such securities  other
than Common Stock to all holders of Common Stock (and the effective date of such
reclassification  shall  be  deemed  to be the  Determination  Date),  and (b) a
subdivision  or  combination,  as the case may be,  of the  number  of shares of
Common Stock  outstanding  immediately prior to such  reclassification  into the
number of shares of Common Stock  outstanding  immediately  thereafter  (and the
effective  date of such  reclassification  shall be  deemed  to be "the day upon
which  such  subdivision   becomes  effective"  or  "the  day  upon  which  such
combination becomes effective", as the case may be, and "the day upon which such
subdivision or combination  becomes  effective"  within the meaning of paragraph
(3) of this Section 2(b)). Rights,  options,  warrants or convertible securities
issued by the Company entitling the holders thereof to subscribe for or purchase
shares  of  Common  Stock,  which  rights,  options,   warrants  or  convertible
securities  (i) are deemed to be  transferred  with such shares of Common Stock,
(ii) are not  exercisable  and  (iii)  are also  issued  in  respect  of  future
issuances of Common  Stock,  in each case in clauses (i) through (iii) until the
occurrence of a specified event or events ("Trigger Event"),  shall for purposes
of this Section 2(b) not be deemed  issued until the  occurrence of the earliest
Trigger Event.

     (8) Except as otherwise  provided in the last  sentence of this  subsection
(8) of Section 2(0) for the purpose of any  computation  under  paragraphs  (2),
(4),  (5) or (6) of this  Section  2(b) the  current  market  price per share of
Common Stock on any date shall be  calculated by the Company and be deemed to be
the average of the daily  Closing  Prices for the five (5)  consecutive  Trading
Days  selected by the Company  commencing  not more than ten (10)  Trading  Days
before,  and ending not later than,  the earlier of the day in question  and the
day before the "ex date" with respect to the issuance or distribution  requiring
such computation.  For purposes of this paragraph, the term "ex date", when used
with respect to any issuance or distribution,  means the first date on which the
Common Stock trades  regular way in the applicable  securities  market or on the
applicable  securities  exchange  without the fight to receive such  issuance or
distribution.  The current market price with respect to any option issued to any
employee or director of the Company or  consultant  to the Company  shall be the
fair market  value on the date of grant  determined  by  reference to the market
price on the day of the grant of such option or to the market price at the close
of business on the Trading Day immediately preceding such grant.

     (9) No  adjustment  in the  Conversion  Rate shall be required  unless such
adjustment (plus any adjustments not previously made by reason of this paragraph
(9)) would require an increase or decrease of at least one percent in such rate;
provided,  however,  that any adjustments  which by reason of this paragraph (9)
are not  required to be made shall be carried  forward and taken into account in
any subsequent  adjustment.  All calculations under this Section 2 shall be made
to the nearest cent or to the nearest  one-hundredth of a share, as the case may
be.

     (10) The Company may make such  increases in the  Conversion  Rate, for the
remaining  term of the  Securities  or any  shorter  term,  in addition to those
required by


<PAGE>



     paragraphs  (1),  (2),  (3),  (4),  (5) and (6) of this  Section 2(b) as it
     considers  to be  advisable in order to avoid or diminish any income tax to
     any  holders  of shares of Common  Stock  resulting  from any  dividend  or
     distribution  of  stock  or  issuance  of  rights,  options,   warrants  or
     convertible securities to purchase or subscribe for stock or from any event
     treated as such for income tax purposes.

     (c) Whenever the  Conversion  Rate is adjusted as provided in Section 2(b),
the Company  shall  compute the  adjusted  Conversion  Rate in  accordance  with
Section 2(b) and shall prepare a certificate (the "Conversion Rate Certificate")
signed by the Senior Financial Officer of the Company setting forth the adjusted
Conversion  Rate and  showing  in  reasonable  detail  the facts upon which such
adjustment is based,  and shall promptly  deliver such certificate to the holder
of this Security. If the holders of the Convertible Notes and the Company cannot
agree in writing as to the adjusted  Conversion  Rate in accordance with Section
2(b), the holders of the  Convertible  Notes and the Company shall determine the
adjusted Conversion Rate in accordance with the following procedure. The holders
of the  Convertible  Notes and the Company  shall each  appoint  one  registered
securities broker,  licensed with the Securities and Exchange Commission to sell
securities  to the  public,  which  broker  shall  be a senior  vice  president,
managing  director or equivalent of a major  securities  brokerage  company with
offices in New York, New York.  Each of such brokers shall have no less than ten
(10) years  experience  in such field,  shall be  unaffiliated  with,  and their
employer securities brokerage company shall be unaffiliated with, the holders of
the Convertible Notes and the Company and shall not have previously participated
in any  underwriting  of the  Company's  Common Stock in any public  offering or
provided any Material  investment  banking or corporate advisory services to the
Company.  The holders of the Convertible  Notes and the Company shall make their
appointments  promptly and, in any event,  within thirty (30) days from the date
of the  Conversion  Rate  Certificate.  The two brokers  shall meet and shall be
instructed  to render a  determination  of the adjusted  Conversion  Rate to the
holders of the  Convertible  Notes and the Company within sixty (60) days of the
date of the Conversion Rate  Certificate.  If the two brokers cannot agree, then
each broker  shall render their  independent  determination  and the two brokers
shall simultaneously  therewith provide the name of a third broker acceptable to
the two brokers meeting the criteria set forth above.  The third broker shall be
instructed  to render a  determination  of the adjusted  Conversion  Rate within
thirty (30) days of his or her appointment.  The two closest  determinations  of
the adjusted Conversion Rate shall be averaged and shall constitute the adjusted
Conversion  Rate.  If the two  brokers  cannot  agree upon a third  broker,  the
selection of a third broker  shall be  submitted to binding  arbitration  in New
York, New York under the rules of the American Arbitration  Association.  In the
event that the  difference  between the  Company's  calculation  of the adjusted
Conversion Rate and the  calculation of the adjusted  Conversion Rate determined
by the  foregoing  process is five  percent  (5%) or greater  then the costs and
expenses  of the  brokers  and  any  arbitration  shall  be  paid  by and be the
obligation  of the  Company and in the event that such  difference  is less than
five percent (5%) the holders of the  Convertible  Notes (as a group) shall each
pay its pro rata share of 50% of such costs and expenses  and the Company  shall
pay 50% of such costs and expenses.

     (d) In case:


                                       7

<PAGE>



     (1) the  Company  shall  declare a dividend  or other  distribution  on its
Common Stock payable (i) otherwise than  exclusively in cash or (ii) exclusively
in cash in an amount that would require any adjustment pursuant to Section 2(b);
or

     (2) the Company  shall  authorize the granting to the holders of its Common
Stock of rights, options, warrants or convertible securities to subscribe for or
purchase any shares of capital stock of any class or of any other rights; or

     (3) of any  reclassification  of the Common Stock of the Company, or of any
consolidation,  merger or share exchange to which the Company is a party and for
which  approval  of any  shareholders  of the  Company  is  required,  or of the
conveyance, sale, transfer or lease of all or substantially all of the assets of
the Company; or

     (4) of the voluntary or involuntary dissolution,  liquidation or winding up
of the Company; or

     (5) the Company or any Subsidiary  shall commence a tender offer for all or
a portion of the  Company's  outstanding  shares of Common Stock (or shall amend
any such tender offer);

then the Company shall cause to be delivered to the holder of this Security,  at
least 20 days (or 10 days in any case  specified  in  clause  (1) or (2)  above)
prior  to the  applicable  record,  expiration  or  effective  date  hereinafter
specified,  a notice  stating  (x) the date on which a record is to be taken for
the  purpose  of such  dividend,  distribution,  rights,  options,  warrants  or
convertible  securities or, if a record is not to be taken, the date as of which
the  holders  of  Common  Stock  of  record  to be  entitled  to such  dividend,
distribution,  rights,  options,  warrants or  convertible  securities are to be
determined,  (y) the date on which the right to make  tenders  under such tender
offer  expires  or (z) the date on which such  reclassification,  consolidation,
merger,  share  exchange,   conveyance,   transfer,  sale,  lease,  dissolution,
liquidation  or winding up is expected to become  effective,  and the date as of
which it is expected that holders of Common Stock of record shall be entitled to
exchange  their shares of Common Stock for  securities,  cash or other  property
deliverable upon such reclassification,  consolidation,  merger, share exchange,
conveyance,  transfer,  sale,  lease,  dissolution,  liquidation  or winding up.
Neither the failure to give such notice nor any defect  therein shall affect the
legality or validity of the proceedings  described in clauses (1) through (5) of
this Section 2(d).

     (e) The Company  shall at all times reserve and keep  available,  free from
preemptive  rights,  out of its  authorized but unissued  Common Stock,  for the
purpose of effecting the  conversion of the Security,  the full number of shares
of Common Stock then issuable upon the conversion of this Security.


                                       8

<PAGE>



     (f) Except as provided in the next  sentence,  the Company will pay any and
all taxes and duties  that may be payable in respect of the issue or delivery of
shares of Common Stock on  conversion of this  Security.  The Company shall not,
however,  be  required to pay any tax or duty which may be payable in respect of
any  transfer  involved in the issue and delivery of shares of Common Stock in a
name  other  than that of the  holder  of this  Security,  and no such  issue or
delivery  shall be made  unless and until the Person  requesting  such issue has
paid to the Company the amount of any such tax or duty,  or has  established  to
the satisfaction of the Company that such tax or duty has been paid.

     (g) The  Company  agrees  that all  shares  of  Common  Stock  which may be
delivered upon  conversion of the Security,  upon such delivery,  will have been
duly authorized and validly issued and will be fully paid and nonassessable (and
shall be issued out of the Company's  authorized but unissued Common Stock) and,
except as provided in the second  sentence of Section 2(f), the Company will pay
all taxes, liens and charges with respect to the issue thereof.

     (h) In case of any consolidation of the Company with any other Person,  any
merger of the Company into another  Person or of another Person into the Company
(other than a merger which does not result in any reclassification,  conversion,
exchange or cancellation  of outstanding  shares of Common Stock of the Company)
or any conveyance,  sale,  transfer or lease of all or substantially  all of the
properties and assets of the Company, the Person formed by such consolidation or
resulting from such merger or which acquires such properties and assets,  as the
case may be,  shall  execute  and  deliver  to the  holder  of this  Security  a
supplemental  agreement  providing  that such  holder has the right,  during the
period this  Security  shall be  convertible  as specified in Section  2(a),  to
convert  this  Security  only into the kind and amount of  securities,  cash and
other property receivable upon such  consolidation,  merger,  conveyance,  sale,
transfer or lease  (including  any Common Stock  retainable)  by a holder of the
number of shares of Common Stock of the Company into which this  Security  might
have been converted immediately prior to such consolidation, merger, conveyance,
sale, transfer or lease, assuming such holder of Common Stock of the Company (i)
is not a Person  with which the  Company  consolidated,  into which the  Company
merged or which  merged  into the  Company  or to which such  conveyance,  sale,
transfer or lease was made, as the case may be (a "Constituent  Person"),  or an
Affiliate  of a  Constituent  Person and (ii) failed to  exercise  its rights of
election,  if any,  as to the kind or  amount  of  securities,  cash  and  other
property receivable upon such consolidation,  merger, conveyance, sale, transfer
or lease  (provided  that if the kind or  amount of  securities,  cash and other
property receivable upon such consolidation, merger, conveyance, sale, transfer,
or lease is not the same for each  share of  Common  Stock of the  Company  held
immediately prior to such consolidation,  merger, conveyance,  sale, transfer or
lease by others  than a  Constituent  Person or an  Affiliate  of a  Constituent
Person  and in  respect of which  such  rights of  election  shall not have been
exercised  ("Non-electing Share"), then for the purpose of this Section 2(h) the
kind and amount of  securities,  cash and other  property  receivable  upon such
consolidation,  merger,  conveyance,  sale,  transfer or lease by the holders of
each Non-electing  Share shall be deemed to be the kind and amount so receivable
per  share  by a  plurality  of  the  Non-electing  Shares).  Such  supplemental
agreement  shall provide for  adjustments  which,  for events  subsequent to the
effective date of such


                                       9

<PAGE>



supplemental  agreement,  shall be as nearly equivalent as may be practicable to
the  adjustments  provided for in this Section 2. The above  provisions  of this
Section  2(h)  shall  similarly  apply to  successive  consolidations,  mergers,
conveyances,  sales, transfers or leases. In this paragraph,  "securities of the
kind receivable" upon such consolidation,  merger, conveyance, transfer, sale or
lease by a holder of Common Stock means securities that, among other things, are
registered  and freely  transferable  under the  Securities  Act, and listed and
approved  for  quotation  in all  securities  markets,  in each case to the same
extent as such securities so receivable by a holder of Common Stock.

     (i) The  Company  (i) will effect all  registrations  with,  and obtain all
approvals  by, all  governmental  authorities  that may be  necessary  under any
United States Federal or state law  (including the Securities  Act, the Exchange
Act and  state  securities  and Blue Sky laws)  for the  shares of Common  Stock
issuable upon conversion of this Security to be lawfully issued and delivered as
provided  herein,  and  thereafter  publicly  traded (if  permissible  under the
Securities Act) and qualified or listed as contemplated by clause (ii) (it being
understood  that the Company  shall not be required to register the Common Stock
issuable on conversion  hereof under the Securities  Act, except pursuant to the
Registration Rights Agreement between the Company and the initial holder of this
Security);  and (ii) will list the shares of Common Stock  required to be issued
and delivered upon conversion of Securities, prior to such issuance or delivery,
on each national securities exchange on which outstanding Common Stock is listed
or  quoted  at the time of such  delivery,  or if the  Common  Stock is not then
listed on any securities exchange,  to qualify the Common Stock for quotation on
the Nasdaq National Market or such other inter-dealer  quotation system, if any,
on which the Common Stock is then quoted.

     (j) For purposes  hereof:  (references  to Sections  shall mean Sections of
this Security unless otherwise specified)

     "Affiliate"  of any  specified  Person means any other  Person  directly or
indirectly  controlling  or  controlled  by or under  direct or indirect  common
control  with  such  specified  Person.  For the  purposes  of this  definition,
"control",  when used with respect to any specified  Person,  means the power to
direct the  management  and  policies of such  Person,  directly or  indirectly,
whether  through the ownership of voting  securities,  by contract or otherwise;
and the terms  "controlling" and "controlled"  have meanings  correlative to the
foregoing.

     "Business  Day" means any day other than a Saturday,  a Sunday or other day
which shall be in Boston, Massachusetts or New York, New York or a legal holiday
or a day on which  commercial  banks in Boston,  Massachusetts  or New York, New
York are required or authorized to be closed.

     "Cash Distribution" means the distribution by the Company to holders of its
Common Stock of cash,  other than any cash that is distributed  upon a merger or
consolidation  to  which  Section  2(h)  applies  or as part  of a  distribution
referred to in paragraph (4) of Section 2(b).

                                       10


<PAGE>


     "Change of Control" is defined in Section 3(f)(2).

     "Closing" is defined in Section 1 of the Note Purchase Agreement.

     "Closing Price" means, with respect to the Common Stock of the Company, for
any day, the reported last sale price per share on the Nasdaq  National  Market,
or, if the Common  Stock is not  admitted  to  trading  on the  Nasdaq  National
Market, on the principal national securities exchange or inter-dealer  quotation
system on which the Common  Stock is listed or admitted  to  trading,  or if not
admitted  to trading on the Nasdaq  National  Market,  or listed or  admitted to
trading on any national  securities  exchange or inter-dealer  quotation system,
the   average  of  the   closing   bid  and  asked   prices  per  share  in  the
over-the-counter  market as furnished by any New York Stock Exchange member from
selected from time to time by the Company for that purpose.

     "Code"  means the Internal  Revenue  Code of 1986,  as amended from time to
time, and the rules and regulations promulgated thereunder from time to time.

     "Common  Stock" means the Common  Stock,  par value $.01 per share,  of the
Company  authorized  at the  date of this  instrument  as  originally  executed.
Subject to the  provisions  of Section  20a),  shares  issuable on conversion or
repurchase of this Security  shall include only shares of Common Stock or shares
of any class or classes of common stock resulting from any  reclassification  or
reclassifications thereof; provided, however, that if at any time there shall be
more than one such resulting class, the shares so issuable on conversion of this
Security shall include  shares of all such classes,  and the shares of each such
class then so issuable shall be  substantially in the proportion which the total
number of shares of such class resulting from all such  reclassifications  bears
to the  total  number  of shares  of all such  classes  resulting  from all such
reclassifications.

     "Convertible  Note(s)"shall  mean one or more of the Company's 9.00% Senior
Convertible Notes due June 30, 2004.

     "Conversion Price" is defined in Section 1.

     "Conversion Rate" is defined in Section 2(a).

     "Default"  means an event or condition the occurrence or existence of which
would,  with the lapse of time or the giving of notice or both,  become an Event
of Default.

     "Designated Office" is defined in the Preamble.

     "Determination   Date"   means,   in  the  case  of  a  dividend  or  other
distribution, including the issuance of rights, options, warrants or convertible
securities, to the date fixed for the determination of those entitled to receive
such dividend or other distribution, and in the case of a tender offer, the last
time that tenders could have been made pursuant to such tender offer.

                                       11


<PAGE>



     "Environmental  Laws" means any and all Federal,  state, local, and foreign
statutes,  laws, regulations,  ordinances,  rules,  judgments,  orders, decrees,
permits,  licenses,  written  agreements  or written  governmental  restrictions
relating to pollution and the  protection of the  environment  or the release of
any materials into the  environment,  including but not limited to those related
to hazardous  substances or wastes,  air  emissions  and  discharges to waste or
public systems.

     "ERISA"  means the Employee  Retirement  Income  Security  Act of 1974,  as
amended from time to time, and the rules and regulations  promulgated thereunder
from time to time in effect.

     "ERISA Affiliate" means any trade or business (whether or not incorporated)
that is treated as a single employer together with the Company under section 414
of the Code.

     "Excess Purchase Payment" means the product of(A) the excess, if any, of(i)
the amount of cash plus the fair market  value (as  determined  in good faith by
the Company's Board of Directors) of any non-cash  consideration  required to be
paid with respect to one share of Common  Stock  acquired or to be acquired in a
tender offer made by the Company or any Subsidiary of the Company for all or any
portion of the Common  Stock over (ii) the current  market price per share as of
the last time that  tenders  could have been made  pursuant to such tender offer
and (B) the  number of  shares  validly  tendered  and not  withdrawn  as of the
Determination Date in respect of such tender offer.

     "Event of Default" is defined in the preamble to Section 4.

     "Exchange Act" shall mean the Securities  Exchange Act of 1934, as amended,
or  any  successor  Federal  statute,  and  the  rules  and  regulations  of the
Securities and Exchange Commission promulgated thereunder, all as the same shall
be in effect from time to time.

     "GAAP" means  generally  accepted  accounting  principles as in effect from
time to time in the United States of America.

     "Hazardous  Materials"  means any and all  pollutants,  toxic or  hazardous
wastes or any other substances that might pose a hazard to health or safety, the
remediate, on of which may be required or the generation, manufacture, refining,
production, processing, treatment, storage, handling, transportation,  transfer,
use, disposal, release, discharge,  spillage, seepage, or filtration of which is
restricted,   prohibited  or  penalized  by  any  applicable  Environmental  Law
(including, without limitation,  asbestos, urea formaldehyde foam insulation and
polychlorinated biphenyls).

     "holder"  means,  with  respect to this  Security or any other  Convertible
Note,  the Person in whose name it is registered  in the register  maintained by
the Company pursuant to Section 6(d).



                                       12


<PAGE>



     "Lien"  means,  with respect to any Person,  any  mortgage,  lien,  pledge,
charge, security interest or other encumbrance,  or any interest or title of any
vendor,  lessor,  lender or other  secured  party to or of such Person under any
conditional sale or other title retention agreement or Capital Lease (as defined
by  GAAP),  upon or  with  respect  to any  property  or  asset  of such  Person
(including in the case of stock, stockholder agreements, voting trust agreements
and all similar arrangements).

     "Make-Whole Amount" is defined in Section 4(g).

     "Material" means material in relation to the business, operations, affairs,
financial  condition,  assets,  properties,  or prospects of the Company and its
Subsidiaries taken as a whole.

     "Material  Adverse  Effect"  means a  material  adverse  effect  on (a) the
business,  operations,  affairs,  financial  condition,  assets,  properties  or
prospects  of the  Company  and its  Subsidiaries  taken as a whole,  or (b) the
ability of the  Company  to  perform  its  obligations  under the Note  Purchase
Agreement,  the Registration  Rights Agreement and the Convertible Notes, or (c)
the validity or enforceability of this Agreement or the Convertible Notes.

     "Multiemployer Plan" means any Plan that is a "multiemployer plan" (as such
term is defined in section 4001(a)(3) of ERISA).

     "Note Purchase Agreement" is defined in the Preamble.

     "PBGC"  means the  Pension  Benefit  Guaranty  Corporation  referred to and
defined in ERISA or any successor thereto.

     "Person" means an individual,  partnership,  corporation, limited liability
company,  association,  trust, unincorporated  organization,  or a government or
agency or political subdivision thereof.

     "Plan"  means an  "employee  benefit  plan" (as defined in section  3(3) of
ERISA) that is or,  within the preceding  five years,  has been  established  or
maintained,  or to which  contributions are or, within the preceding five years,
have been made or required to be made, by the Company or any ERISA  Affiliate or
with respect to which the Company or any ERISA Affiliate may have any liability.

     "Purchaser(s)"  JOHN HANCOCK  MUTUAL LIFE INSURANCE  COMPANY;  JOHN HANCOCK
VARIABLE LIFE INSURANCE COMPANY and HANCOCK MEZZANINE PARTNERS

     "Registration  Rights  Agreement" means the  Registration  Rights Agreement
dated as of the date hereof among the Purchasers and the Company.

                                       13


<PAGE>



     "Repurchase Date" is defined in Section 3(a).

     "Repurchase Price" is defined in Section 3(a).

     "Responsible  Officer"  means any Senior  Financial  Officer  and any other
senior officer of the Company with  responsibility for the administration of the
relevant covenants in this Security or in the Note Purchase Agreement.

     "Securities Act" shall mean the Securities Act of 1933, as amended,  or any
successor  Federal statute,  and the rules and regulations of the Securities and
Exchange Commission promulgated  thereunder,  all as the same shall be in effect
from time to time.

     "Senior  Financial  Officer" means the chief financial  officer,  principal
accounting officer, treasurer or comptroller of the Company.

     "Subsidiary" means, as to any Person, any corporation, association or other
business entity in which such Person or one or more of its  Subsidiaries or such
Person  and one or more of its  Subsidiaries  owns  sufficient  equity or voting
interests  to  enable  it or them (as a group)  ordinarily,  in the  absence  of
contingencies,  to elect a majority  of the  directors  (or  Persons  performing
similar  functions) of such entity, and any partnership or joint venture if more
than a 50% interest in the profits or capital thereof is owned by such Person or
one or  more  of its  Subsidiaries  or  such  Person  and  one  or  more  of its
Subsidiaries  (unless  such  partnership  can and  does  ordinarily  take  major
business actions without the prior approval of such Person or one or more of its
Subsidiaries). Unless the context otherwise clearly requires, any reference to a
"Subsidiary" is a reference to a Subsidiary of the Company.

     "Trading  Day" means (i) if the Common  Stock is admitted to trading on the
Nasdaq  National  Market  or any  other  system of  automated  dissemination  of
quotations of securities  prices,  a day on which trades may be effected through
such  system;  (ii) if the Common Stock is listed or admitted for trading on the
New York Stock  Exchange or any other  national  securities  exchange,  a day on
which such  exchange is open for  business;  or (iii) if the Common Stock is not
admitted  to trading on the Nasdaq  National  Market or listed or  admitted  for
trading on any  national  securities  exchange or any other  system of automated
dissemination of quotation of securities prices, a day on which the Common Stock
is traded regular way in the over-the-counter market and for which a closing bid
and a closing asked price for the Common Stock are available.

     3. Right to Require  Repurchase.  (a) In the event that a Change in Control
shall  occur,  then the holder of this  Security  shall have the right,  at such
holder's option, to require the Company to repurchase,  and upon the exercise of
such right the Company shall  repurchase,  this Security,  or any portion of the
principal  amount  hereof  that is  equal to  $1,000  or any  integral  multiple
thereof,  on the date (the  "Repurchase  Date") that is thirty (30) Trading Days
after the date on which the Company  gives notice  thereof to the holder of this
Security,  at a purchase  price  equal to 100% of the  principal  amount of this
Security to be repurchased plus interest accrued to

                                       14


<PAGE>



the  Repurchase  Date  (the  "Repurchase  Price");   provided,   however,   that
installments  of interest on this Security whose stated  maturity is on or prior
to the Repurchase  Date shall be payable to the holder of this Security,  or one
or more predecessor  Securities,  registered as such on the relevant Record Date
according to their terms. At the option of the Company, the Repurchase Price may
be paid in cash or subject to the  fulfillment  by the Company of the conditions
set forth in each of Section 5 and Section 6 and subject to the  limitations set
forth in each of Section 5 and Section 6, by delivery of shares of Common  Stock
or in common  stock of any Person  which  succeeds  the  Company up to a maximum
amount often  percent (10%) of the then issued and  outstanding  Common Stock or
common stock of such Person following any Change in Control, provided,  however,
the cash plus the fair market  value of such shares  shall equal the  Repurchase
Price.  The  Company  agrees to give the holder of this  Security  notice of any
Change in Control, by facsimile  transmission  confirmed in writing by overnight
courier  service,  promptly  and in any event within two (2) Trading Days of the
occurrence thereof.

     (b) To exercise a repurchase right, the holder shall deliver to the Company
on or before the 10th Trading Day prior to the  Repurchase  Date,  together with
this  Security,  written  notice of the holder's  exercise of such right,  which
notice  shall set forth the name of the  holder,  the number of shares of Common
Stock then owned by such holder and its affiliates, the principal amount of this
Security to be repurchased  (and, if this Security is to be repurchased in part,
the portion of the principal  amount thereof to be  repurchased  and the name of
the  person in which  the  portion  thereof  to remain  outstanding  after  such
repurchase is to be registered) and a statement that an election to exercise the
repurchase  right is being made  thereby  and, in the event that the  Repurchase
Price shall be paid in whole or in pan by the  delivery  of shares,  as provided
above,  the name or names  (and the  addresses)  in which the  certificates  for
shares shall be issued.  Such written notice shall be  irrevocable,  except that
the right of the holder to convert  this  Security  (or the portion  hereof with
respect to which the repurchase  fight is being  exercised) shall continue until
the close of business on the  Repurchase  Date (or if the Company  elects to pay
the Repurchase Price by delivery of shares as provided above, until the close of
business on the Trading Day  immediately  preceding the first delivery of shares
with respect thereto).

     (c) In the event a repurchase  right shall be exercised in accordance  with
the terms  hereof,  the Company  shall pay or cause to be paid to the holder the
Repurchase Price in cash or shares, as provided above, together with accrued and
unpaid interest to the Repurchase Date; provided,  however, that installments of
interest  that  mature on or prior to the  Repurchase  Date  shall be payable in
cash, to the holders of this Security,  or one or more  predecessor  Securities,
registered as such at the close of business on the relevant regular record date.

     (d) If this Security (or portion thereof) is surrendered for repurchase and
is not so paid on or prior to the Repurchase  Date, the principal amount of this
Security (or such portion  hereof,  as the case may be) shall,  until paid, bear
interest to the extent  permitted by applicable law from the Repurchase  Date at
eleven percent (11%) per annum,  and shall remain  convertible into Common Stock
until the  principal of this Security (or portion  thereof,  as the case may be)
shall have been paid or duly provided for.

                                       15


<PAGE>



     (e) If this  Security  is to be  repurchased  only in  part,  it  shall  be
surrendered  to the Company at the  Designated  Office (with,  if the Company so
requires,  due  endorsement  by, or a written  instrument  of  transfer  in form
satisfactory  to the Company duly executed by, the holder hereof or his attorney
duly  authorized in writing),  and the Company shall execute and make  available
for delivery to the holder without service charge, a new Security or Securities,
containing identical terms and conditions, each in an authorized denomination in
aggregate  principal  amount  equal  to and in  exchange  for the  unrepurchased
portion of the principal of the Security so surrendered.

     (f) For purposes of this Section 3.

     (1) the term "beneficial owner" shall be determined in accordance with Rule
13d-3  promulgated  by the Securities  and Exchange  Commission  pursuant to the
Exchange Act; and

     (2) a "Change in  Control"  shall be deemed to have  occurred  at the time,
after the original issuance of this Security, of:

     (i) the  acquisition  by any Person of  beneficial  ownership,  directly or
indirectly,  through a  purchase,  merger or other  acquisition  transaction  or
series of transactions, of shares of capital stock of the Company entitling such
Person  to  exercise  50% or more of the  total  voting  power of all  shares of
capital  stock of the Company  entitled  to vote  generally  in the  election of
directors  (any shares of voting  stock of which such  Person is the  beneficial
owner that are not then  outstanding  being deemed  outstanding  for purposes of
calculating such  percentage)  other than any such acquisition by the Company or
any employee benefit plan of the Company; or

     (ii) any  consolidation  or merger of the Company  with or into,  any other
Person,  any  merger  of  another  Person  with  or  into  the  Company,  or any
conveyance,  transfer,  sale, lease or other disposition of all or substantially
all of the  assets of the  Company to another  Person  (other  than (a) any such
transaction  (x)  which  does not  result in any  reclassification,  conversion,
exchange or cancellation of outstanding  shares of Common Stock and (y) pursuant
to which holders of Common Stock  immediately prior to such transaction have the
entitlement to exercise, directly or indirectly, 50% or more of the total voting
power of all shares of capital stock  entitled to vote generally in the election
of  directors  of the  continuing  or surviving  Person  immediately  after such
transaction  and  (b)  any  merger  which  is  effected  solely  to  change  the
jurisdiction of incorporation of the Company and results in a  reclassification,
conversion or exchange of outstanding  shares of Common Stock into solely shares
of common stock,

     4. Events of Default.  (a) "Event of Default",  wherever used herein, means
any one of the following  events  (whatever the reason for such Event of Default
and whether it shall be voluntary or  involuntary or be effected by operation of
law or pursuant to any judgment,

                                       16


<PAGE>


decree  or  order  of  any  court  or  any  order,  rule  or  regulation  of any
administrative or governmental body):

     (1) (A) default in the payment of any  principal or premium,  if any,  upon
this Security when the same becomes due and payable, whether at maturity or at a
date fixed for  prepayment or by  declaration or otherwise or (B) default in the
payment of any interest upon this Security when it becomes due and payable,  and
continuance of such default for a period of five (5) days; or

     (2) default by the Company in the performance of its obligations in respect
of any  conversion of this Security (or any portion  hereof) in accordance  with
Section 2; or

     (3)  failure  by the  Company  to give any  notice of a Change  of  Control
required to be delivered in accordance with Section 3(a); or

     (4) default in the  performance,  or breach,  of any  material  covenant or
warranty  of the  Company  herein,  in the Note  Purchase  Agreement,  or in the
Registration  Rights  Agreements (other than a covenant or warranty a default in
the performance or breach of which is specifically  dealt with elsewhere in this
Section 4(a)) and  continuance of such default or breach for a period of 30 days
after the  earlier to occur  of(A) the  Company's  obtaining  knowledge  of such
default or (B) the Company's receiving written notice specifying such default or
breach and requiring it to be remedied and stating that such notice is a "Notice
of Default" hereunder; or

     (5) any  representation  or warranty made in writing by or on behalf of the
Company or by any  officer  of the  Company  furnished  in  connection  with the
transactions  contemplated  hereby proves to have been false or incorrect in any
material respect on the date as of which made; or

     (6) a final  judgment or judgments for the payment of money  aggregating in
excess of  $250,000  are  rendered  against  one or more of the  Company and its
Subsidiaries  and which  judgments are not,  within 60 days after entry thereof,
bonded,  discharged or stayed pending  appeal,  or are not discharged  within 60
days after the expiration of such stay; or

     (7) a  default  under  any  bond,  debenture,  note or  other  evidence  of
indebtedness  for  money  borrowed  by the  Company,  or  under  any  agreement,
mortgage,  indenture or  instrument  under which there may be issued or by which
there may be secured or evidenced  any  indebtedness  for money  borrowed by the
Company,  with a principal  amount  then  outstanding  in excess of  $1,000,000,
whether  such  indebtedness  now exists or shall  hereafter  be  created,  which
default shall constitute a failure to pay the principal of such indebtedness (in
whole or in any pan greater than  $1,000,000) when due and payable or shall have
resulted in such  indebtedness (in whole or in any part greater than $1,000,000)
becoming or being  declared due and payable  prior to the date on which it would
otherwise have become due and payable; or

                                       17


<PAGE>



         (8)  if(i) any Plan  other  than a  Multiemployer  Plan  shall  fail to
satisfy the minimum funding  standards of ERISA or the Code for any plan year or
part thereof or a waiver of such  standards  or  extension  of any  amortization
period is sought or  granted  under  section  412 of the Code,  (ii) a notice of
intent to terminate any Plan other than a Multiemployer  Plan shall have been or
is  reasonably  expected  to be  filed  with the  PBGC or the  PBGC  shall  have
instituted  proceedings  under  ERISA  section  4042 to  terminate  or appoint a
trustee to administer any Plan other than a Multiemployer Plan or the PBGC shall
have  notified  the  Company  or any ERISA  Affiliate  that a Plan  other than a
Multiemployer  Plan may  become a  subject  of any such  proceedings,  (iii) the
aggregate  "amount of  unfunded  benefit  liabilities"  (within  the  meaning of
section  4001(a)(18) of ERISA) under all Plans other than a Multiemployer  Plan,
determined in accordance with Title IV of ERISA, shall exceed $250,000, (iv) the
Company or any ERISA Affiliate shall have incurred or is reasonably  expected to
incur any liability  pursuant to Title I or IV of ERISA or the penalty or excise
tax provisions of the Code relating to employee  benefit plans,  (v) the Company
or any  ERISA  Affiliate  withdraws  from any  Multiemployer  Plan,  or (vi) the
Company or any  Subsidiary  establishes or amends any employee  welfare  benefit
plan that  provides  post-employment  welfare  benefits  in a manner  that would
increase the liability of the Company or any Subsidiary thereunder; and any such
event or events described in clauses (i) through (vi) above, either individually
or together with any other such event or events, could reasonably be expected to
have a Material  Adverse  Effect.  (As used in this Section  4(a)(8),  the terms
"employee  benefit  plan" and  "employee  welfare  benefit  plan" shall have the
respective meanings assigned to such terms in Section 3 of ERISA.); or

         (9) if, as a result of any Change of Control or any other consolidation
or  merger,  the  holding by the  Purchasers  or any  assignees  thereof of this
Security  or the  holding  of any  Common  Stock or common  stock of any  Person
succeeding the Company,  issued to the Purchasers or any assignees thereof after
conversion of this Security  would  constitute,  with respect to any Plan (other
than a  Multiemployer  Plan) a prohibited  transaction  which would  violate the
prohibitions  of section 406 of ERISA or which would  subject any  "disqualified
person"  (as  defined in section  4975(e)(2)  of the Code) to a tax  pursuant to
section 4975(c)(1)(A)-(D) of the Code; or

         (10) the entry by a court having  jurisdiction in the premises of (A) a
decree or order for relief in respect of the Company in an  involuntary  case or
proceeding  under  any  applicable  Federal  or  State  bankruptcy,  insolvency,
reorganization  or other  similar  law or (B) a decree  or order  adjudging  the
Company a bankrupt or  insolvent,  or  approving  as  properly  filed a petition
seeking reorganization,  arrangement, adjustment or composition of or in respect
of the  Company  under any  applicable  Federal or State law,  or  appointing  a
custodian,  receiver,  liquidator,  assignee,  trustee,  sequestrator  or  other
similar official of the Company or of any substantial  part of its property,  or
ordering the winding up or  liquidation of its affairs,  and the  continuance of
any such decree or order for relief or any such other  decree or order  unstayed
and in effect for a period of 60 consecutive days; or

                                       18


<PAGE>



     (11) the  commencement  by the  Company of a voluntary  case or  proceeding
under any applicable Federal or State bankruptcy, insolvency,  reorganization or
other  similar  law or of any  other  case or  proceeding  to be  adjudicated  a
bankrupt  or  insolvent,  or the consent by it to the entry of a decree or order
for relief in respect of the Company in an involuntary  case or proceeding under
any applicable Federal or State bankruptcy, insolvency,  reorganization or other
similar law or to the  commencement  of any  bankruptcy  or  insolvency  case or
proceeding  against  it, or the filing by it of a petition  or answer or consent
seeking  reorganization or similar relief under any applicable  Federal or State
law, or the consent by it to the filing of such  petition or to the  appointment
of or taking possession by a custodian, receiver, liquidator, assignee, trustee,
sequestrator or other similar official of the Company or of any substantial part
of its  property,  or the  making  by it of an  assignment  for the  benefit  of
creditors,  or not paying its debts as they become due or the admission by it in
writing of its  inability to pay its debts  generally as they become due, or the
taking of corporate action by the Company in furtherance of any such action.

     b) If an Event of  Default  (other  than an Event of Default  specified  in
Section 4(a)(10) or 4(a)(11)) occurs and is continuing,  then in every such case
the holder of this  Security  may  declare  the  principal  hereof to be due and
payable  immediately,  by a notice in writing to the Company,  and upon any such
declaration  such  principal  and  all  accrued  interest  hereon  shall  become
immediately due and payable without presentment, demand, protest or other notice
of any kind,  all of which are hereby  expressly  waived,  and the Company shall
forthwith upon any such  acceleration pay to the holder of this Security (i) the
entire principal of and interest accrued on this Security, and (ii) in addition,
to the extent  permitted  by  applicable  law, an amount equal to the Make Whole
Amount,  as  liquidated  damages  and  not as a  penalty;  and,  in  case of the
occurrence  of an Event of Default of the  character  described in  subdivisions
4(a)(10) or 4(a)(11)  the  principal of and accrued  interest on this  Security,
ipso facto shall become  immediately  due and payable without any declaration or
other act of the  holder  of this  Security  and  without  presentment,  demand,
protest or other notice of any kind, all of which are hereby  expressly  waived,
and the Company shall forthwith upon any such  acceleration pay to the holder of
this Security (x) the entire  principal of and interest accrued on this Security
and (y) in addition,  if such Event of Default is  "Voluntary"  (as  hereinafter
defined),  to the extent  permitted  by  applicable  law, an amount equal to the
Make-Whole Amount, as liquidated damages and not as a penalty.

     For  purposes  of this  section  4(a),  "Voluntary"  shall mean an Event of
Default of the character  described in  subdivisions  4(a)(10) or 4(a)(11) which
shall  have  been  (X)  procured  by  the  Company  or  any  officer,  director,
stockholder or Affiliate of the Company or (y) primarily the result of action or
inaction by the Company or by any officer, director, stockholder or Affiliate of
the Company.

     (c) In case any one or more of the Events of Default  specified  in section
4(a) shall have occurred,  and  irrespective of whether this Security has become
or has been declared  immediately due and payable under section 4(a), the holder
of this Security may proceed to protect and enforce its rights either by suit in
equity or by action at law, or both. The Company stipulates that the remedies at
law of the holder of this  Security  in the event of any  Default or  threatened
Default by the Company in the  performance of or compliance with any covenant or
agreement in

                                       19


<PAGE>



this Security,  the Note Purchase Agreement or the Registration Rights Agreement
are not and will not be adequate and that,  to the fullest  extent  permitted by
law,  such  terms may be  specifically  enforced  by a decree  for the  specific
performance  thereof,  whether by an injunction  against a violation  thereof or
otherwise.

     (d) No remedy  conferred in this Security,  the Note Purchase  Agreement or
the  Registration  Rights  Agreement  is intended to be  exclusive  of any other
remedy,  and each and every  such  remedy  shall be  cumulative  and shall be in
addition to every other remedy given hereunder or thereunder or now or hereafter
existing at law or in equity or by statute or otherwise.

     (e) No course of dealing  between the Company and any of its  Subsidiaries,
on the one hand,  and the holder of this  Security,  on the other  hand,  and no
delay by any such holder in  exercising  any rights  hereunder or under the Note
Purchase  Agreement or the  Registration  Rights  Agreement  shall  operate as a
waiver of any rights of such holder.

     (f) In case any one or more of the Events of Default  specified  in section
4(a) shall have occurred, all amounts to be applied to the prepayment or payment
of this  Security  shall be applied,  after the payment of all related costs and
expenses incurred by the holder of this Security (including, without limitation,
compensation  to  any  and  all  trustees,  liquidators,  receivers  or  similar
officials and reasonable  fees,  expenses and  disbursements of counsel) in such
order of priority as is determined by the holder of this Security.

     (g) The term "Make-Whole  Amount" means, with respect to this Security,  an
amount equal to the excess,  if any, of the  Discounted  Value of the  Remaining
Scheduled  Payments  with respect to the Called  Principal of this Security over
the amount of such Called Principal,  provided that the Make-Whole Amount may in
no event be less than zero.  For the  purposes  of  determining  the  Make-Whole
Amount, the following terms have the following meanings:

     "Called  Principal" means, with respect to this Security,  the principal of
this Security that has become or is declared to be  immediately  due and payable
pursuant to Section 4(b).

     "Discounted  Value"  means,  with  respect to the Called  Principal of this
Security,  the amount obtained by discounting all Remaining  Scheduled  Payments
with respect to such Called Principal from their respective  scheduled due dates
to the Settlement Date with respect to such Called Principal, in accordance with
accepted  financial  practice  and at a  discount  factor  (applied  on the same
periodic  basis as that on which  interest on this Security is payable) equal to
the Reinvestment Yield with respect to such Called Principal.

     "Reinvestment  Yield" means,  with respect to the Called  Principal of this
Security,  150 basis points over the yield to maturity implied by (i) the yields
reported,  as of 10:00  A.M.  (New York City time) on the  second  Business  Day
preceding  the  Settlement  Date with respect to such Called  Principal,  on the
display designated as "PX-I" of the Bloomberg  Financial Markets Services Screen
for actively  traded U.S.  Treasury  securities  having a maturity  equal to the
Remaining Average Life of such Called Principal as of such

                                       20


<PAGE>



Settlement  Date, or (ii) if such yields are not reported as of such time or the
yields  reported as of such time are not  ascertainable,  the Treasury  Constant
Maturity Series Yields  reported,  for the latest day for which such yields have
been so reported as of the second  Business Day  preceding the  Settlement  Date
with respect to such Called Principal, in Federal Reserve Statistical Release H.
15 (519) (or any  comparable  successor  publication)  for actively  traded U.S.
Treasury  securities  having a constant  maturity equal to the Remaining Average
Life of such Called  Principal as of such  Settlement  Date.  Such implied yield
will  be  determined,  if  necessary,  by  (a)  converting  U.S.  Treasury  bill
quotations  to  bond-equivalent  yields in accordance  with  accepted  financial
practice and (b)  interpolating  linearly  between (1) the actively  traded U.S.
Treasury  security  with the duration  closest to and greater than the Remaining
Average  Life  and (2) the  actively  traded  U.S.  Treasury  security  with the
duration closest to and less than the Remaining Average Life.

"Remaining Average Life" means, with respect to any Called Principal, the number
of years  (calculated to the nearest  one-twelfth year) obtained by dividing (i)
such Called Principal into (ii) the sum of the products  obtained by multiplying
(a) the principal  component of each Remaining Scheduled Payment with respect to
such  Called  Principal  by (b) the number of years  (calculated  to the nearest
one-twelfth  year) that will elapse between the Settlement  Date with respect to
such Called  Principal and the scheduled  due date of such  Remaining  Scheduled
Payment.

"Remaining  Scheduled  Payment" means,  with respect to the Called  Principal of
this Security,  all payments of such Called  Principal and interest thereon that
would be due after the Settlement Date with respect to such Called  Principal if
no payment of such Called  Principal  were made prior to its scheduled due date,
provided that if such Settlement  Date is not a date on which interest  payments
are due to be made under the terms of this Security, then the amount of the next
succeeding  scheduled interest payment will be reduced by the amount of interest
accrued to such Settlement Date.

     "Settlement  Date"  means,  with  respect to the Called  Principal  of this
Security,  the date on which such Called  Principal or has become or is declared
to be immediately due and payable pursuant to Section 4(b).

     5.  Consolidation,  Merger, Etc. (a) The Company shall not consolidate with
or merge into any other Person or,  directly or  indirectly,  convey,  transfer,
sell or lease  all or  substantially  all of its  properties  and  assets to any
Person, and the Company shall not permit any Person to consolidate with or merge
into the Company or, directly or indirectly, convey, transfer, sell or lease all
or substantially all of its properties and assets to the Company, unless:

     (1) in case the Company shall consolidate with or merge into another Person
or convey,  transfer,  sell or lease all or substantially  all of its properties
and assets to any Person,  the Person formed by such consolidation or into which
the Company is merged or the Person which  acquires by  conveyance,  transfer or
sale, or which leases, all or substantially all the properties and assets of the
Company shall be a corporation, limited


                                       21


<PAGE>



liability company, partnership or trust, shall be organized and validly existing
under  the laws of the  United  States of  America,  any  State  thereof  or the
District of Columbia and shall expressly  assume,  by an agreement  supplemental
hereto,  executed  and  delivered  to  the  holder  of  this  Security  in  form
satisfactory  to the holder,  the due and punctual  payment of the  principal of
(and  premium,  if any) and  interest on this  Security and the  performance  or
observance  of every  covenant of this Security on the part of the Company to be
performed or observed,  including the conversion  rights  provided herein (which
shall thereafter relate to common stock of such successor, on a basis reasonably
designed to preserve the economic  value to the holder of this  Security of such
conversion rights);

     (2)  immediately  after giving effect to such  transaction and treating any
indebtedness  which  becomes an obligation of the Company or a Subsidiary of the
Company as a result of such  transaction  as having been incurred by the Company
or such Subsidiary of the Company at the time of such  transaction,  no Event of
Default, and no event which, after notice or lapse of time or both, would become
an Event of Default, shall have happened and be continuing;

     (3) the Company has  delivered to the holder of this  Security an officers'
certificate stating that such consolidation,  merger, conveyance, transfer, sale
or lease and, if a  supplemental  agreement is required in connection  with such
transaction,  such supplemental agreement, comply with this Section and that all
conditions  precedent herein provided for relating to such transaction have been
complied with; and

     (4) counsel for the Company has delivered to the holder of this Security an
opinion of such counsel with respect to such consolidation,  merger, conveyance,
transfer,  sale  or  lease,  and if a  supplemental  agreement  is  required  in
connection with such  transaction,  such supplemental  agreement,  which opinion
shall be, in form and  substance,  reasonably  acceptable to such holder and its
counsel.

     (b) Upon any  consolidation  of the Company  with, or merger of the Company
into,  any other  Person or any  conveyance,  transfer,  sale or lease of all or
substantially all of the properties and assets of the Company in accordance with
Section 5(a), the successor  Person formed by such  consolidation  or into which
the Company is merged or to which such  conveyance,  transfer,  sale or lease is
made shall succeed to, and be substituted  for, and may exercise every right and
power of,  the  Company  under  this  Security  with the same  effect as if such
successor Person had been named as the Company herein, and thereafter, except in
the case of a lease, the predecessor Person shall be relieved of all obligations
and covenants under this Security.

     6.  payment in Stock.  (a) The  Company may elect to pay some or all of the
Repurchase Price by delivery of shares of Common Stock or shares of common stock
in any Person  succeeding  the  Company,  if and only if, each of the  following
conditions shall be satisfied  (without limiting any other conditions  contained
herein):

     (1) Any such payment shall be made in five equal  installments,  on each of
the five consecutive  Trading Days ending on and including the third Trading Day
immediately preceding

                                       22


<PAGE>



the date when any cash payment would  otherwise be due, and the shares of Common
Stock or common  stock of any  Person  succeeding  the  Company  deliverable  in
payment of each such  installment  shall have a fair market value as of the date
of such  installment  of not less  than 20% of the  amount of such  payment  due
hereunder  which is payable in shares of stock.  For purposes of this Section 6,
the fair  market  value of shares of Common  Stock  shall be equal to 95% of the
Closing Price for the immediately preceding Trading Day;

     (2) In the event any shares of Common  Stock or common  stock of any Person
succeeding  the  Company to be issued in  respect  of any  amount due  hereunder
require  registration under any Federal securities law before such shares may be
freely transferable without being subject to any transfer restrictions under the
Securities  Act of  1933  upon  issuance,  such  registration  shall  have  been
completed  and shall have become  effective  prior to the date of the first such
installment;

     (3) In the event any shares of Common  Stock or common  stock of any Person
succeeding  the  Company to be issued in  respect  of any  amount due  hereunder
require  registration  with or approval of any governmental  authority under any
State law or any other  Federal law before such shares may be validly  issued or
delivered upon issuance or transferred freely, such registration shall have been
completed or have become  effective and such approval  shall have been obtained,
in each case, prior to the date of the first such installment;

     (4) The shares of Common Stock or common stock of any Person succeeding the
Company  deliverable  in payment of such  amount due  hereunder  shall have been
approved for quotation in the Nasdaq  National Market  immediately  prior to the
date of the first such installment or, if at the time its shares of Common Stock
or shares of common  stock of any Person  succeeding  the  Company are listed or
admitted for trading on any national securities  exchange,  the shares of Common
Stock or common stock in any Person succeeding the Company and deliverable shall
have been so listed or admitted for trading.

     (5) All shares of Common Stock or common stock of any Person succeeding the
Company  deliverable in payment of such amount due hereunder shall,  upon issue,
be duly and  validly  issued and fully paid and  non-assessable  and free of any
preemptive rights;

     (6) In respect of each such payment date,  the Company shall have given the
holder of this  Security not less than 10 nor more than 15 Trading  Days' notice
of its election to effect payment in respect of such payment date by delivery of
shares of Common  Stock;  provided  that any such  notice  shall  accompany  the
Company's notice of a Change of Control relating thereto; and

     (7) The Company shall deliver,  or cause to be delivered a certificate from
the Person succeeding the Company which states,  that after giving effect to any
Change of Control that the holding by the Purchasers or any assignees thereof of
this Security,  or the holding of any Common Stock or common stock of any Person
succeeding the Company after  conversion of this Security would not constitute a
prohibited transaction which would violate the prohibition of

                                       23


<PAGE>


section  406 of ERISA or which  would  subject  any  "disqualified  person"  (as
defined in section  4975(e)(2)  of the Code) to a tax  pursuant to section  4975
(c)(1)(A)-(D) of the Code.

     If all of the  conditions  set forth in this Section 6(a) are not satisfied
in accordance with the terms hereof, any such amount due hereunder shall be paid
by the Company only in cash.

     (b) Any issuance of shares of Common Stock or shares of common stock of any
Person  succeeding  the  Company  in respect of any  installment  due  hereunder
pursuant  to this  Section 6 shall be deemed to have been  effected  immediately
prior to the close of business on the date of delivery of such  installment  and
the person or persons in whose name or names any certificate or certificates for
shares of Common Stock shall be issuable upon such  delivery  shall be deemed to
have  become  on such  date the  holder  or  holders  of  record  of the  shares
represented thereby;  provided,  however,  that in case any installment shall be
due on a date when the stock transfer books of the Company shall be closed,  the
person or persons in whose name or names the  certificate  or  certificates  for
such shares are to be issued shall be deemed to have become the record holder or
holders  thereof  for all  purposes  at the  opening  of  business  on the  next
succeeding  day on which  such  stock  transfer  books are open.  No  payment or
adjustment  shall be made for  dividends  or  distributions  on any Common Stock
issued pursuant to this Section 6 declared prior to the relevant  delivery date;
and

     (c) Any issuance and delivery of certificates for shares of common stock or
shares of common  stock of any Person  succeeding  the Company  pursuant to this
Section 6 shall be made without  charge to the holder of this  Security for such
certificates  or for any tax or duty in respect of the  issuance  or delivery of
such certificates or the securities represented thereby.

     7.  Other.  (a) No  provision  of this  Security  shall alter or impair the
obligation  of the  Company,  which is absolute  and  unconditional,  to pay the
principal  of,  premium,  if any, and  interest on this  Security in cash at the
times,  places and rate,  and in the coin or currency,  herein  prescribed or to
convert this Security as herein provided.

     (b) The Company will give prompt  written  notice to the holder of Security
of any change in the location of the Designated Office.

     (c) The transfer of this Security is registrable  on the Security  Register
of the Company upon surrender of this Security for  registration  of transfer at
the Designated Office,  duly endorsed by, or accompanied by a written instrument
of transfer in form  satisfactory  to the Company  duly  executed by, the holder
hereof or his attorney duly authorized in writing, and thereupon one or more new
Securities,  of authorized  denominations  and for the same aggregate  principal
amount,  will be  issued  to the  designated  transferee  or  transferees.  Such
Securities are issuable only in registered form without coupons in denominations
of $1,000 and any integral multiple thereof. No service Charge shall be made for
any such registration of transfer,  but the Company may require payment of a sum
sufficient to recover any tax or other governmental charge payable in connection
therewith.  Prior to due  presentation  of this  Security  for  registration  of
transfer, the Company and any agent of the Company may treat the Person in whose
name this

                                       24


<PAGE>



Security is registered  as the owner  thereof for all  purposes,  whether or not
this  Security be  overdue,  and neither the Company nor any such agent shall be
affected by notice to the contrary.

     (d) The  Company  shall keep at the  Designated  Office a register  for the
registration  and  registration of transfers of Convertible  Notes. The name and
address of each holder of one or more Convertible  Notes,  each transfer thereof
and the name and address of each  transferee  of one or more  Convertible  Notes
shall be registered in such register.  Prior to due presentment for registration
of transfer,  the Person in whose name any Convertible  Note shall be registered
shall be deemed and  treated as the owner and holder  thereof  for all  purposes
hereof,  and the Company Shall not be affected by any notice or knowledge to the
contrary.  The Company shall give to any holder of a  Convertible  Note promptly
upon request therefor, a complete and correct copy of the names and addresses of
all registered holders of Convertible Notes.

     (e) Upon surrender of any  Convertible  Note at the  Designated  Office for
registration  of  transfer  or  exchange  (and in the  case of a  surrender  for
registration of transfer,  duly endorsed or accompanied by a written  instrument
of transfer duly executed by the registered  holder of such  Convertible Note or
his  attorney  duly  authorized  in writing and  accompanied  by the address for
notices  of each  transferee  of such  Convertible  Note or part  thereof),  the
Company shall execute and deliver,  at the Company's expense (except as provided
below),  one or more new Convertible  Notes (as requested by the holder thereof)
in exchange  therefor,  in an  aggregate  principal  amount  equal to the unpaid
principal amount of the surrendered  Convertible Note. Each such new Convertible
Note shall be payable to such  Person as such  holder may  request  and shall be
substantially in the form of this Security. Each such new Convertible Note shall
be dated and bear interest from the date to which  interest shall have been paid
on the  surrendered  Convertible  Note or  dated  the  date  of the  surrendered
Convertible  Note if no interest  shall have been paid thereon.  The Company may
require  payment  of a sum  sufficient  to cover any  stamp tax or  governmental
charge  imposed in respect of any such  transfer of this  Security.  Convertible
Notes shall not be transferred in denominations of less than $100,000,  provided
that if  necessary  to enable the  registration  of  transfer by a holder of its
entire  holding  of  Convertible  Notes,  one  Convertible  Note  may  be  in  a
denomination  of less than  $100,000.  Any  transferee,  by its  acceptance of a
Convertible  Note registered in its name (or the name of its nominee),  shall be
deemed  to have  made the  representation  set  forth in  Section  3 of the Note
Purchase Agreement.

     (f) Upon receipt by the Company of evidence  reasonably  satisfactory to it
of the  ownership of and the loss,  theft,  destruction  or  mutilation  of this
Security  (which evidence shall be notice from such holder of such ownership and
such loss, theft, destruction or mutilation), and

     (i) in the case of loss,  theft or  destruction,  of  indemnity  reasonably
satisfactory  to it  (provided  that if the holder of this  Security is, or is a
nominee for, an original holder or another institutional investor holder of this
Security,  such Person's own unsecured agreement of indemnity shall be deemed to
be satisfactory), or

     (ii) in the case of mutilation, upon surrender and cancellation thereof,

                                       25


<PAGE>



the Company at its own expense shall execute and deliver, in lieu thereof, a new
Convertible  Note,  dated and bearing  interest from the date to which  interest
shall have been paid on such lost,  stolen,  destroyed or mutilated  Convertible
Note or dated the date of such lost, stolen,  destroyed or mutilated Convertible
Note if no interest shall have been paid thereon.

     (G) THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE
LAWS OF THE STATE OF NEW YORK, UNITED STATES OF AMERICA.

     (h) So long as you or your  nominee  shall be holder of this  Security  and
notwithstanding  anything in this Security to the contrary, the Company will pay
all sums becoming due hereunder for principal,  Make-Whole  Amount,  if any, and
interest by the method and at the address  specified for such purpose below your
name in  Schedule I of the Note  Purchase  Agreement,  or by such  other  method
provided in the Preamble or at such other address as you shall have from time to
time  specified  to the  Company  in  writing  for  such  purpose,  without  the
presentation  or  surrender  of this  Security,  or the  making of any  notation
hereon,  except that upon written request of the Company made  concurrently with
or  reasonably  promptly  after  payment  in full of this  Security,  you  shall
surrender  this Security for  cancellation,  reasonably  promptly after any such
request to the  Company  at its  principal  executive  office or at the place of
payment most  recently  designated  by the  Company.  Prior to any sale or other
disposition of this Security you will, at your election,  either endorse thereon
the amount of  principal  paid  thereon and the last date to which  interest has
been paid  thereon or surrender  this  Security to the Company in exchange for a
new Convertible  Note pursuant to the terms hereof.  The Company will afford the
benefits of this  Section to any  institutional  investor  that is the direct or
indirect transferee of this Security.

                     [END OF PAGE - SIGNATURE PAGE FOLLOWS]


                                       26


<PAGE>



     IN WITNESS  WHEREOF.  the  Company  has  caused  this  Security  to be duly
executed under its corporate seal.

Dated:   July 6,            ,1999
      ---------------------

                                            CELGENE CORPORATION


                                            By:
                                               --------------------------
                                               Name:  Robert J. Hugin
                                               Title: Senior Vice President CFO
Attest

- ------------------------------
Name:  Sanford Kaston
Title: Treasurer; CIO


                                       27


<PAGE>



                    ELECTION OF HOLDER TO REQUIRE REPURCHASE

     1. Pursuant to Section 3(a) of this Security, the undersigned hereby elects
to have all or a portion of this Security repurchased by the Company.

     2. The undersigned hereby directs the Company to pay [choose one] (a) it or
(b) Name: ; address: ; Social Security or Other Taxpayer  Identification Number,
if any:  , an  amount  in cash or equal to 100% of the  principal  amount  to be
repurchased (as set forth below),  plus interest accrued to the Repurchase Date,
as provided herein.



<PAGE>



                                CONVERSION NOTICE

     The undersigned  holder of this Security hereby  irrevocably  exercises the
option to convert this Security,  or any portion of the principal  amount hereof
(which is an  integral  multiple  of $1,000)  below  designated,  into shares of
Common Stock  (subject to the  limitation  set forth in the second  paragraph of
Section 2(a) of the Security) in accordance with the terms of this Security, and
directs that such shares,  together  with a check in payment for any  fractional
share and any Security  representing any unconverted principal amount hereof, be
delivered to and be registered in the name of the undersigned unless a different
name has been indicated below. If shares of Common Stock or Securities are to be
registered in the name of a Person other than the  undersigned,  the undersigned
will pay all transfer taxes payable with respect thereto. Any amount required to
be paid by the undersigned on account of interest accompanies this Security.

Dated:
      ---------------------------                    -------------------------
                                                      Signature



                                                                   EXHIBIT 10.27

                          REGISTRATION RIGHTS AGREEMENT

     REGISTRATION  RIGHTS  AGREEMENT,  dated as of July 6, 1999,  by and between
Celgene Corporation,  a Delaware  corporation (the "Company"),  and John Hancock
Mutual Life Insurance Company, John Hancock Variable Life Insurance Company, and
Hancock Mezzanine Partners L.P. (collectively, the "Purchasers" and singly, each
"Purchaser")  entered into in connection with the issuance of a Convertible Note
due June 30, 2004  convertible  into shares of Common Stock,  par value $.01 per
share ("Common Stock") of the Company.

     1. Certain Definitions.

     For purposes of this  Registration  Rights  Agreement,  the following terms
shall have the following respective meanings:

     (a) "Commission" shall mean the Securities and Exchange Commission,  or any
other  federal  agency  at  the  time  administering  the  Exchange  Act  or the
Securities Act, whichever is the relevant statute for the particular purpose.

     (b) Convertible Note" shall mean the Convertible Note due June 30, 2004, of
the Company to be issued and sold to the  Purchaser,  and any  Convertible  Note
issued in exchange therefor or in lieu thereof.

     (c) "Effective  Time" shall mean the date on which the Commission  declares
the Shelf Registration  effective or on which the Shelf  Registration  otherwise
becomes effective.

     (d) "Exchange Act" shall mean the  Securities  Exchange Act of 1934, or any
successor thereto and the rules and regulations promulgated  thereunder,  as the
same shall be amended from time to time.

     (e)  "Issue  Date"  shall  mean  the date on  which a  Convertible  Note is
initially issued.

     (f) The term "person" shall mean a corporation,  association,  partnership,
organization,  business, individual, government or political subdivision thereof
or governmental agency.

     (g)  ";Registration  Expenses" shall have the meaning  assigned  thereto in
Section 4 hereof.

     (h)  ".Securities  Act"  shall  mean the  Securities  Act of  1933,  or any
successor thereto and the rules and regulations promulgated  thereunder,  as the
same shall be amended from time to time.


<PAGE>


     (i) "Shares" means the shares of Common Stock issuable upon exercise of the
Convertible Note.

     (j) "Shelf Registration" shall have the meaning assigned thereto in Section
2 hereof.

     In addition,  capitalized  terms not defined  herein shall have the meaning
ascribed in the Convertible Note.

     2. Shelf Registration of Shares.

     (a) Not  later  than  July 6,  2000,  the  Company  shall  file  under  the
Securities Act a "shelf"  registration  statement providing for the registration
of, and the sale on a  continuous  or delayed  basis by the  Purchasers  of, all
shares issuable upon conversion of the Convertible  Notes,  pursuant to Rule 415
under the  Securities  Act  and/or any  similar  rule that may be adopted by the
Commission  (the  "Shelf  Registration").  The  Company  agrees  to use its best
efforts to cause the Shelf  Registration  to become or be declared  effective no
later than 45  calendar  days after the  filing  thereof  and to keep such Shelf
Registration continuously effective for a period ending on the earliest to occur
of (i) the  second  anniversary  of the Issue  Date,  (ii)  notification  to the
Company by each Purchaser that it has sold all Shares  issuable upon  conversion
of the  Convertible  Notes so owned by it, or (iii) such time as the  Purchasers
may sell all of such shares  pursuant to Rule 144(k) under the  Securities  Act.
The Company  further agrees,  if necessary,  to supplement or make amendments to
the Shelf  Registration,  if required by the rules,  regulations or instructions
applicable  to  the  registration  form  used  by the  Company  for  such  Shelf
Registration  or by the Securities Act or rules and  regulations  thereunder for
shelf  registration,  and the Company agrees to furnish to each Purchaser copies
of any such  supplement  or amendment  prior to its being used and/or filed with
the Commission,  and will not file any such supplement or amendment to which any
Purchaser reasonably objects.

     (b) Notwithstanding the foregoing, following the effectiveness of the Shelf
Registration,  the Company many, at any time,  suspend the effectiveness of such
Shelf Registration for up to 60 days, as appropriate (a "Suspension Period"), by
giving notice to each  Purchaser,  if the Company shall have determined that the
Company may be required to disclose any  material  corporate  development  which
disclosure  may  jeopardize a material  transaction or otherwise have a material
adverse effect on the Company. The Company will use its best efforts to minimize
the length of any Suspension Period. Notwithstanding the foregoing, no more than
one  Suspension  Period may occur within any 180 day period,  and no  Suspension
Period  shall be  effective  at any time the  Company  or any  affiliate  of the
Company is publicly  selling  shares of the capital stock of the Company  (other
than  pursuant  to a  registration  statement  on the  Securities  and  Exchange
Commission  Form  S-8).  The  period  of any  such  suspension  of  registration
statement  shall be added to the period of time the  Company  agrees to keep the
Shelf Registration  effective as provided in Section 2(a). Each Purchaser agrees
that, upon receipt of any notice from the Company of a Suspension  Period,  such
Purchaser shall forthwith discontinue disposition of shares covered by the Shelf
Registration  until such Purchaser (i) is advised in writing by the Company that
the use of the

                                        2


<PAGE>



applicable prospectus may be resumed, (ii) has received copies of a supplemental
or amended  prospectus,  if  applicable,  and (iii) has  received  copies of any
additional  or  supplemental  filings  which are  incorporation  or deemed to be
incorporated by reference in such prospectus.

     3. Registration Procedures.

     (a) In connection  with any  obligation of the Company to register  Shares,
the Company shall use its best efforts to effect or cause such  registration  to
permit the sale of the Shares by the Purchasers in accordance  with the intended
method  or  methods  of  distribution   thereof   described  in  the  applicable
registration statement.  In connection therewith,  the Company shall, within the
time specified in Section 2 above:

     (i) prepare and file with the  Commission a  registration  statement on any
form which may be utilized by the Company and which shall permit the disposition
of the Shares in  accordance  with the intended  method or methods  thereof,  as
specified in writing by each Purchaser;

     (ii) comply with the  provisions of the  Securities Act with respect to the
disposition  of all of the Shares  covered  by such  registration  statement  in
accordance with the intended  methods of disposition by each Purchaser set forth
in such registration statements;

     (iii) provide (A) each  Purchaser,  (B) the  underwriters  (which term, for
purposes of these  Registration  Rights,  shall include a person deemed to be an
underwriter  within the meaning of Section 2(11) of the Securities Act), if any,
thereof,  (C) the sales or placement  agent, if any,  therefor,  (D) counsel for
such  underwriters or agent,  and (E) counsel for the Purchasers the opportunity
to  participate  in  the  preparation  of  such  registration  statement,   each
prospectus included therein or filed with the Commission,  and each amendment or
supplement thereto;

     (iv) for a  reasonable  period  prior to the  filing  of such  registration
statement,  and  throughout  the  period  specified  in  Section 2 hereof,  make
available for inspection by the parties  referred to in Section  3(a)(iii) above
who shall certify to the Company that they have a current  intention to sell the
Shares  pursuant  to  the  registration   statement  such  financial  and  other
information  and books  and  records  of the  Company,  and cause the  officers,
employees,  counsel and independent  certified public accountants of the Company
to respond to such inquiries,  as shall be reasonably necessary, in the judgment
of the respective  counsel referred to in such Section,  to conduct a reasonable
investigation  within the meaning of Section 11 of the Securities Act; provided,
however,  that each such party shall be required to maintain in  confidence  and
not to disclose to any other person any  information or records  provided by the
Company and clearly marked or otherwise adequately  identified by the Company as
being confidential  until such time as (A) such information  becomes a matter of
public record (whether by virtue of its inclusion in

                                        3


<PAGE>



such registration statement or otherwise),  or (B) such person shall be required
so to disclose such  information  pursuant to the subpoena or order of any court
or other governmental agency or body having jurisdiction over the matter or over
such party  (subject  to the  requirements  of such  order,  and only after such
person  shall  have  given  the  Company  prompt  prior  written  notice of such
requirement),  or (C) such  information  is  required  to be set  forth in .such
registration  statement or the prospectus included therein or in an amendment to
such registration  statement or an amendment or supplement to such prospectus in
order that such registration statement,  prospectus, amendment or supplement, as
the case may be, does not contain an untrue statement of a material fact or omit
to state therein a material  fact required to be stated  therein or necessary to
make the statements therein not misleading;

     (v) promptly notify each Purchaser,  the sales or placement  agent, if any,
therefor and the  managing  underwriter  or  underwriters,  if any,  thereof and
confirm  such advice in writing,  (A) when such  registration  statement  or the
prospectus  included  therein  or any  prospectus  amendment  or  supplement  or
post-effective  amendment has been filed, and, with respect to such registration
statement or any post-effective  amendment,  when the same has become effective,
(B) of any  comments  by the  Commission  and  by  the  Blue  Sky or  securities
commissioner  or regulator  of any state with respect  thereto or any request by
the Commission for amendments or supplements to such  registration  statement or
prospectus or for additional information,  (C) of the issuance by the Commission
of any stop order suspending the effectiveness of such registration statement or
the initiation or overt threatening of any proceedings for that purpose,  (D) if
at any time the  representations  and warranties of the Company  contemplated by
Section 5 hereof cease to be true and correct in all material  respects,  (E) of
the receipt by the Company of any notification with respect to the suspension of
the  qualification  of the Shares for sale in any jurisdiction or the initiation
or overt threatening of any proceeding for such purpose, or (F) at any time when
a  prospectus  is required to be  delivered  under the  Securities  Act, if such
registration  statement,  prospectus,  prospectus  amendment  or  supplement  or
post-effective  amendment,  or any document  incorporated by reference in any of
the foregoing, contains an untrue statement of a material fact or omits to state
any  material  fact  required  to be stated  therein  or  necessary  to make the
statements therein not misleading in light of the circumstances then existing;

     (vi) use its best efforts to obtain the withdrawal of any order  suspending
the effectiveness of such registration statement or any post-effective amendment
thereto at the earliest practicable date;

     (vii)  if  requested  by any  managing  underwriter  or  underwriters,  any
placement or sales agent or any Purchaser,  promptly incorporate in a prospectus
supplement or  post-effective  amendment such  information as is required by the
applicable   rules  and   regulations  of  the  Commission  that  such  managing
underwriter  or  underwriters,  such agent or such  Purchaser  specify should be
included therein


                                      4

<PAGE>



relating to the terms of the sale of such Shares, including, without limitation,
information with respect to the number of Shares being sold by such Purchaser or
agent or to any underwriters,  the name and description of such Purchaser, agent
or underwriter,  the offering price of such Shares and any discount,  commission
or other compensation  payable in respect thereof, the purchase price being paid
therefor  by such  underwriters  and  with  respect  to any  other  terms of the
offering  of the  Shares  to be sold  by  such  Purchaser  or  agent  or to such
underwriters;  and make all required  filings of such  prospectus  supplement or
post-effective  amendment  promptly  after  notification  of the  matters  to be
incorporated in such prospectus supplement or post-effective amendment;

     (viii) furnish to each  Purchaser,  each placement or sales agent,  if any,
therefor, each underwriter,  if any, thereof and the respective counsel referred
to in Section  3(a)(iii) a copy of such  registration  statement  in the form in
which it became effective,  each such amendment and supplement  thereto (in each
case  including  all exhibits  thereto and documents  incorporated  by reference
therein)  and such number of copies of such  registration  statement  (excluding
exhibits  thereto  and  documents   incorporated  by  reference  therein  unless
specifically so requested by any Purchaser,  agent or  underwriter,  as the case
may be) and of the prospectus included in such registration statement (including
each preliminary prospectus and any summary prospectus),  in conformity with the
requirements of the Securities Act, and such other documents,  as any Purchaser,
agent,  if any,  and  underwriter,  if any, may  reasonably  request in order to
facilitate the offering and  disposition of the Shares owned by such  Purchaser,
offered or sold by such agent or underwritten by such  underwriter and to permit
such  Purchaser,  agent and  underwriter  to  satisfy  the  prospectus  delivery
requirements  of the Securities  Act; and the Company hereby consents to the use
of such prospectus  (including such preliminary and summary  prospectus) and any
amendment  or  supplement  thereto  by any  Purchaser  and by any such agent and
underwriter,  in each case in the form most  recently  provided to such party by
the Company,  in connection  with the offering and sale of the Shares covered by
the  prospectus  (including  such  preliminary  and summary  prospectus)  or any
supplement or amendment thereto;

     (ix) use its best  efforts  to (A)  register  or  qualify  the Shares to be
included in such  registration  statement under such securities laws or blue sky
laws of such  jurisdictions as each Purchaser and each placement or sales agent,
if any, therefor and underwriter,  if any, thereof shall reasonably request, (B)
keep such registrations or qualifications in effect and comply with such laws so
as to permit the  continuance  of  offers,  sales and  dealings  therein in such
jurisdictions  during the respective  periods such  registration  statements are
required  to remain  effective  under  Section 2 above and for so long as may be
necessary to enable each  Purchaser or any agent or  underwriter to complete its
distribution of Shares pursuant to such registration  statement and (C) take any
and all other actions as may be reasonably necessary or advisable to enable each
Purchaser, agent, if any, and underwriter, if any, to

                                       5
<PAGE>


consummate  the  disposition  in such  jurisdictions  of such Shares;  provided,
however,  that the  Company  shall not be required  for any such  purpose to (I)
qualify  as a  foreign  corporation  in any  jurisdiction  wherein  it would not
otherwise  be  required  to qualify  but for the  requirements  of this  Section
3(a)(ix) or (II) consent to general service of process in any such jurisdiction;

     (x) use its  best  efforts  to  obtain  the  consent  or  approval  of each
governmental agency or authority,  whether federal, state or local, which may be
required to effect the Shelf  Registration or the offering or sale in connection
therewith or to enable the Purchaser to offer,  or to consummate the disposition
of, its Shares;

     (xi) cooperate with each Purchaser and the managing  underwriters,  if any,
to  facilitate  the  timely   preparation  and  delivery  of  any   certificates
representing   Shares  to  be  sold,  which   certificates   shall  be  printed,
lithographed or engraved,  or produced by any  combination of such methods,  and
which shall not, once sold under the Shelf  Registration,  bear any  restrictive
legends; and, in the case of an underwritten offering,  enable such Shares to be
in such denominations and registered in such names as the managing  underwriters
may request at least two business days prior to any sale of the Shares;

     (xii) enter into one or more underwriting  agreements,  engagement letters,
agency  agreements or similar  agreements,  as appropriate,  including  (without
limitation)  customary  provisions relating to indemnification and contribution,
and take such other  actions in  connections  therewith as any  Purchaser  shall
reasonably  request in order to expedite or facilitate  the  disposition  of the
Shares;

     (xiii)  notify each  Purchaser in writing of any proposal by the Company to
amend or waive any provision of these  Registration  Rights  pursuant to Section
7(g) hereof and of any amendment or waiver effected  pursuant  thereto,  each of
which  notices  shall  contain the text of the  amendment or waiver  proposed or
effected, as the case may be;

     (xiv) in the event that any broker-dealer registered under the Exchange Act
shall  underwrite  any  Shares or  participate  as a member  of an  underwriting
syndicate or selling group or "assist in the  distribution"  (within the meaning
of the Rules of Fair  Practice  and the By-Laws of the National  Association  of
Securities  Dealers,  Inc.  ("NASD"))  thereof,  whether  as an  underwriter,  a
placement or sales agent or a broker or dealer in respect thereof, or otherwise,
assist such  broker-dealer  in complying with the requirements of such Rules and
By-Laws,  including,  without limitation,  by providing such information to such
broker-dealer as may be required in order for such  broker-dealer to comply with
the requirements of the Rules of Fair Practice of the NASD;

                                       6

<PAGE>



     (xv) comply with all applicable  rules and  regulations of the  Commission,
and make generally  available to its security holders as soon as practicable but
in any event not later than  eighteen  months after the  effective  date of such
registration  statement, an earning statement of the Company and in subsidiaries
complying with Section 11(a) of the Securities Act (including,  at the option of
the Company, Rule 158 thereunder); and

     (xvi) use its best  efforts to have the Shares  approved for trading on the
Nasdaq National Market.

     (b) In the event that the Company  would be  required,  pursuant to Section
3(a)(v)(F)  above,  to notify each  Purchaser,  the placement or sales agent, if
any, therefor and the managing underwriters,  if any, thereof, the Company shall
without delay prepare and furnish to each Purchaser,  to each placement or sales
agent, if any, and to each underwriter, if any, a reasonable number of copies of
a  prospectus   supplemented  or  amended  in  form  and  substance   reasonably
satisfactory to them, so that, as thereafter  delivered to purchasers of Shares,
such prospectus shall not contain an untrue statement of a material fact or omit
to state a material fact required to be stated  therein or necessary to make the
statements  therein not misleading in light of the circumstances  then existing.
Each Purchaser  agrees that upon receipt of any notice from the Company pursuant
to Section  3(a)(v)(F)  hereof,  such Purchaser shall forthwith  discontinue the
disposition of Shares pursuant to the registration  statement applicable to such
Shares  until such  Purchaser  shall  have  received  copies of such  amended or
supplemented prospectus, and if so directed by the Company, such Purchaser shall
deliver  to the  Company  (at the  Company's  expense)  all  copies,  other than
permanent  file copies,  then in such  Purchaser's  possession of the prospectus
covering such Shares at the time of receipt of such notice.

     (c) The Company may require any  Purchaser  to furnish to the Company  such
information  regarding such Purchaser and such  Purchaser's  intended  method of
distribution  of the  Shares as the  Company  may from  time to time  reasonably
request in writing,  but only to the extent that such information is required in
order to comply with the  Securities  Act. Each  Purchaser  agrees to notify the
Company as promptly as  practicable  of any  inaccuracy or change in information
previously  furnished by such  Purchaser to the Company or of the  occurrence of
any event in either  case as a result of which any  prospectus  relating to such
registration  contains or would  contain an untrue  statement of a material fact
regarding such Purchaser or such Purchaser's  intended method of distribution of
such Shares or omits to state any material fact regarding such Purchaser or such
Purchaser's intended method of distribution of such Shares required to be stated
therein or necessary to make the  statements  therein not misleading in light of
the  circumstances  then  existing,  and  promptly to furnish to the Company any
additional  information  required to correct and update any previously furnished
information or required so that such prospectus shall not contain,  with respect
to such Purchaser or the  distribution of such Shares,  an untrue statement of a
material fact or omit to state a material fact required to be stated  therein or
necessary  to make  the  statements  therein  not  misleading  in  light  of the
circumstances  then  existing.  Each Purchaser  agrees that upon  delivering any
notice to the Company  pursuant  to this  Section  3(c),  such  Purchaser  shall
forthwith  discontinue the  disposition of Shares  pursuant to the  registration
statement applicable to such Shares until such


                                       7

<PAGE>



Purchaser shall have received copies of such amended or supplemented prospectus,
and if so directed by the Company,  such Purchaser  shall deliver to the Company
(at the Company's expense) all copies,  other than permanent file copies then in
such Purchaser's  possession of the prospectus  covering such Shares at the time
of receipt of such notice.

     4. Registration Expenses.

     The  Company  agrees to bear and to pay or cause to be paid  promptly  upon
request being made therefor all expenses  incident to the Company's  performance
of or  compliance  with these  Registration  Rights as they  relate to the Shelf
Registration,  including,  without  limitation,  (i) all Commission and any NASD
registration  and  filing  fees and  expenses,  (ii) all  fees and  expenses  in
connection with the  qualification of the Shares for offering and sale under the
State  securities  and blue sky laws  referred  to in Section  3(a)(ix)  hereof,
including  reasonable  fees and  disbursements  of counsel for the  placement or
sales agent or underwriters in connection  with such  qualifications,  (iii) all
fees and expenses in  connection  with the approval for trading of the Shares on
the Nasdaq  National  Market,  (iv) all  expenses  relating to the  preparation,
printing,  distribution and reproduction of each registration statement required
to be  filed  hereunder,  each  prospectus  included  therein  or  prepared  for
distribution pursuant hereto, each amendment or supplement to the foregoing, the
certificates  representing  the Shares and all other documents  relating hereto,
(v) internal expenses (including,  without limitation, all salaries and expenses
of the Company's officers and employees  performing legal or accounting duties),
and (vi) fees,  disbursements and expenses of counsel and independent  certified
public  accountants  of the Company  (including  the expenses of any opinions or
"cold  comfort"  letters  required  by  or  incident  to  such  performance  and
compliance)  (collectively,  the "Registration  Expenses").  Notwithstanding the
foregoing,  such  Purchaser  shall  pay all  agency  fees  and  commissions  and
underwriting  discounts and  commissions  attributable to the sale of the Shares
and the fees and  disbursements  of any  counsel  or other  advisors  or experts
retained by such Purchaser in connection with the sale of its shares.

     5. Representations and Warranties.

     The Company  represents  and warrants to, and agrees with,  each  Purchaser
that:

     (a)  Each  registration  statement  covering  Shares  and  each  prospectus
(including any preliminary or summary prospectus) contained therein or furnished
pursuant to Section  3(a)(viii) hereof and any further amendments or supplements
to any such registration  statement or prospectus,  when it becomes effective or
is  filed  with the  Commission,  as the  case  may be,  and,  in the case of an
underwritten  offering  of  Shares,  at  the  time  of  the  closing  under  the
underwriting agreement relating thereto will conform in all material respects to
the requirements of the Securities Act, and will not contain an untrue statement
of a  material  fact or omit to state a  material  fact  required  to be  stated
therein or necessary to make the statements  therein not misleading;  and at all
times subsequent to the Effective Time when a prospectus would be required to be
delivered  under the  Securities  Act, other than from (i) such time as a notice
has been give to such Purchaser  pursuant to Section 3(a)(v)F) hereof until (ii)
such  time as the  Company  furnishes  an  amended  or  supplemented  prospectus
pursuant to Section  3(b) hereof,  each such  registration  statement,  and each
prospectus

                                       8
<PAGE>



(including any summary  prospectus)  contained therein or furnished  pursuant to
Section 3(a)(viii) hereof, as then amended or supplemented,  will conform in all
material  respects  to the  requirements  of the  Securities  Act,  and will not
contain an untrue  statement of a material fact or omit to state a material fact
required to be stated  therein or necessary to make the  statements  therein not
misleading in the light of the circumstances then existing;  provided,  however,
that this  representation  and  warranty  shall not apply to any  statements  or
omissions made in reliance upon and in conformity with information  furnished in
writing to the Company by such Purchaser expressly for use therein.

     (b) Any documents  incorporated by reference in any prospectus  referred to
in Section  5(a)  hereof,  when they become or became  effective  or are or were
filed with the Commission, or if amended, when amended, as the case may be, will
conform  or  conformed  in all  material  respects  to the  requirements  of the
Exchange  Act,  and none of such  documents  will contain or contained an untrue
statement  of a material  fact or will omit or omitted to state a material  fact
required to be stated  therein or necessary to make the  statements  therein not
misleading;  provided,  however, that this representation and warranty shall not
apply to any  statements  or omissions  made in reliance  upon and in conformity
with information furnished in writing to the Company by such Purchaser expressly
for use therein.

     6. Indemnification.

     (a)  Indemnification  by the  Company.  Upon  the  registration  of  Shares
pursuant to Section 2 hereof,  and in  consideration  of the  agreements  of the
Purchasers  contained herein, and as an inducement to the Purchasers to purchase
the Convertible Notes, the Company shall, and it hereby agrees to, indemnify and
hold harmless each Purchaser and each person who  participates as a placement or
sales agent or as an  underwriter in any offering or sale of such Shares against
any losses,  claims,  damages or  liabilities,  joint or several,  to which such
Purchaser  or any  such  agent or  underwriter  may  become  subject  under  the
Securities  Act or  otherwise,  insofar  as  such  losses,  claims,  damages  or
liabilities  (or actions in respect  thereof)  arise out of or are based upon an
untrue statement or alleged untrue statement of a material fact contained in any
registration  statement  under  which  such  Shares  were  registered  under the
Securities  Act,  or any  preliminary,  final or  summary  prospectus  contained
therein or furnished by the Company to such Purchaser, agent or underwriter,  or
any  amendment  or  supplement  thereto,  or arise out of or are based  upon the
omission or alleged  omission to state  therein a material  fact  required to be
stated therein or necessary to make the statements  therein not misleading,  and
the Company shall, and it hereby agrees to, reimburse such Purchaser, such agent
and such underwriter for any legal or other expenses reasonably incurred by them
in connection with  investigating  or defending any such action or claim as such
expenses are incurred;  provided,  however, that the Company shall not be liable
to any such  Person in any such case to the extent  that any such  loss,  claim,
damage  or  liability  arises  out of or is based  upon an untrue  statement  or
alleged  untrue   statement  or  omission  or  alleged  omission  made  in  such
registration statement or preliminary, final or summary prospectus, or amendment
or  supplement  in reliance  upon and in  conformity  with  written  information
furnished  to the Company by such Person  expressly  for use  therein;  provided
further,  however,  that the  Company  shall not be liable to any such Person if
such Person failed to deliver a prospectus in the form most recently provided by
the Company (including any amendments or supplements thereto previously provided
by the

                                        9


<PAGE>



Company),  in any such  case to the  extent  that any  loss,  claim,  damage  or
liability  arises out of or is based  upon an untrue  statement  or an  omission
which was corrected in such most recently  furnished  prospectus  (including any
such amendments or supplements).

     (b)  Indemnification by the Purchaser and any Agents and Underwriters.  The
Company may require,  as a condition to including any Shares in any registration
statement   filed  pursuant  to  Section  2  hereof  and  to  entering  into  an
underwriting  agreement,  if any, with respect  thereto,  that the Company shall
have  received  an  undertaking   reasonably   satisfactory   to  it  from  each
participating  Purchaser and from each  underwriter,  if any,  named in any such
underwriting  agreement,  severally and not jointly or jointly and severally, to
(i) indemnify and hold harmless the Company against any losses,  claims, damages
or liabilities to which the Company may become subject, under the Securities Act
or otherwise, insofar as such losses, claims, damages or liabilities (or actions
in  respect  thereof)  arise out of or are based  upon an  untrue  statement  or
alleged  untrue  statement of a material  fact  contained  in such  registration
statement, or any preliminary,  final or summary prospectus contained therein or
furnished  by the  Company  to  any  Purchaser,  agent  or  underwriter,  or any
amendment or supplement  thereto, or arise out of or are based upon the omission
or alleged  omission  to state  therein a material  fact  required  to be stated
therein or necessary to make the statements therein not misleading, in each case
to the extent,  but only to the extent,  that such untrue  statement  or alleged
untrue  statement or omission or alleged  omission was made in reliance upon and
in  conformity  with  written  information  furnished  to the  Company  by  such
Purchaser or  underwriter  expressly  for use therein,  and (ii)  reimburse  the
Company for any legal or other  expenses  reasonably  incurred by the Company in
connection  with  investigating  or  defending  any such action or claim as such
expenses  are  incurred.  Notwithstanding  the  above,  the  obligation  of such
Purchaser for indemnity  shall be limited to an amount equal to the net proceeds
received by such Purchaser in the applicable underwriting.

     (c) Notices of Claims,  Etc. Promptly after receipt by an indemnified party
under  subsection (a) or (b) above of written notice of the  commencement of any
action,  such  indemnified  party shall,  if a claim in respect thereof is to be
made against an indemnifying party pursuant to the indemnification provisions of
or contemplated by this Section 6, notify such indemnifying  party in writing of
the commencement of such action;  but the omission so to notify the indemnifying
party  shall  not  relieve  it  from  any  liability  which  it may  have to any
indemnified  party  other  than  under  the  indemnification  provisions  of  or
contemplated  by Section 6(a) or 6(b)  hereof.  In case any such action shall be
brought against any indemnified party and it shall notify an indemnifying  party
of the  commencement  thereof,  such  indemnifying  party  shall be  entitled to
participate  therein  and, to the extent that it shall  wish,  jointly  with any
other indemnifying party similarly notified, to assume the defense thereof, with
counsel  satisfactory to such indemnified  party (who shall not, except with the
consent of the indemnified  party, be counsel to the indemnifying  party),  and,
after  notice  from  the  indemnifying  party to such  indemnified  party of its
election so to assume the defense thereof,  such indemnifying party shall not be
liable to such indemnified  party for any legal expenses of other counsel or any
other expenses, in each case subsequently incurred by such indemnified party, in
connection with the defense thereof other than reasonable costs of investigation
unless, in the case of an indemnification  obligation arising under Section (a),
(i) the employment of such additional  counsel has been authorized in writing by
the Company in connection with defending such action,

                                       10


<PAGE>



or (ii) the Company and the  Purchaser  are advised by such  additional  counsel
that the Purchaser has available  defenses  involving a potential  conflict with
the  interests  of the Company,  in which  event,  the fees and expenses of such
additional  counsel shall be borne by the Company.  No indemnifying  party shall
consent to entry of any judgment or enter into any settlement of a claim against
an indemnified party without the consent of the indemnified party which does not
include as an unconditional term thereof the giving by the claimant or plaintiff
to such  indemnified  party of an  unconditional  release from all  liability in
respect to such claim or litigation.

     (d)  Contribution.  Each party hereto  agrees  that,  if for any reason the
indemnification  provisions  contemplated  by Section  6(a) or Section  6Co) are
unavailable to or insufficient to hold harmless an indemnified  party in respect
of any losses,  claims,  damages or liabilities (or actions in respect  thereof)
referred to therein, then each indemnifying party shall contribute to the amount
paid or payable by such  indemnified  party as a result of such losses,  claims,
damages or liabilities (or actions in respect  thereof) in such proportion as is
appropriate to reflect the relative  benefits  received by indemnified  party on
the one hand and the  indemnifying  party on the other from any  offering of the
Shares.  If,  however,  the  allocation  provided by the  immediately  preceding
sentence is not permitted by applicable law or if the  indemnified  party failed
to give the notice required under subsection (c) above,  then each  indemnifying
party shall contribute to such amount paid or payable by such indemnified  party
in such proportion as is appropriate to reflect not only such relative  benefits
but also the relative fault of the indemnifying  party and the indemnified party
in connection  with the  statements or omissions  which resulted in such losses,
claims,  damages or liabilities (or actions in respect thereof),  as well as any
other relevant equitable  considerations.  The relative benefits received by the
Company on the one hand and each Purchaser on the other shall be deemed to be in
the same  proportion as the total  purchase  price  received by the Company upon
issuance of the  Convertible  Note bears to the difference  between the proceeds
from the offering of the Shares  received by such  Purchaser  and such  purchase
price. The relative fault of such indemnifying party and indemnified party shall
be determined by reference to, among other things, whether the untrue or alleged
untrue  statement of a material fact or omission or alleged  omission to state a
material fact relates to information  supplied by such indemnifying  party or by
such indemnified party, and the parties' relative intent,  knowledge,  access to
information  and  opportunity  to correct or prevent such statement or omission.
The  parties   hereto  agree  that  it  would  not  be  just  and  equitable  if
contributions  pursuant  to  this  Section  6(d)  were  determined  by pro  rata
allocation  (even if any Purchaser or any agents or  underwriters or all of them
were  treated  as one  entity  for  such  purpose)  or by any  other  method  of
allocation which does not take account of the equitable  considerations referred
to in this Section 6(d). The amount paid or payable by an indemnified party as a
result of the losses,  claims,  damages,  or liabilities  (or actions in respect
thereof) referred to above shall be deemed to include any legal or other fees or
expenses  reasonably  incurred  by such  indemnified  party in  connection  with
investigating  or  defending  any such  action  or  claim.  Notwithstanding  the
provisions of this Section  6(d),  no Purchaser  shall be required to contribute
any amounts in excess of the amount by which the dollar  amount of the  proceeds
received by such  Purchaser  from the sale of any Shares  (after  deducting  any
fees,  discounts and commissions  applicable  thereto) exceeds the amount of any
damages which such  Purchaser  has  otherwise  been required to pay by reason of
such untrue or alleged untrue statement or omission or alleged omission,  and no
underwriter  shall be required to contribute  any amount in excess of the amount
by

                                       11


<PAGE>



which the total price at which the Shares  underwritten by it and distributed to
the public were  offered to the public  exceeds the amount of any damages  which
such  underwriter has otherwise been required to pay by reason of such untrue or
alleged untrue  statement or omission or alleged  omission.  No person guilty of
fraudulent  misrepresentation  (within  the  meaning  of  Section  11 (f) of the
Securities  Act) shall be  entitled  to  contribute  from any person who was not
guilty of such fraudulent  misrepresentation.  Any underwriters'  obligations in
this Section 6(d) to contribute  shall be several in proportion to the principal
amount of Shares underwritten by them and not joint.

     (e) The  obligations  of the  Company  under  this  Section  6 shall  be in
addition to any liability  which the Company may otherwise have and shall emend,
upon the same terms and  conditions,  to each  officer,  director and partner of
each  Purchaser,  any agent and any  underwriter  and each  person,  if any, who
controls such  Purchaser or any agent or  underwriter  within the meaning of the
Securities  Act;  and the  obligations  of each  Purchaser  and any  agents  and
underwriters  contemplated  by  this  Section  6  shall  be in  addition  to any
liability which such Purchaser or any such agent or  underwriter,  respectively,
may otherwise have and shall extend, upon the same terms and conditions, to each
officer and director of the Company (including any person who, with his consent,
is named in any  registration  statement  as about to become a  director  of the
Company) and to each person, if any, who controls the Company within the meaning
of the Securities Act.

     7. Miscellaneous

     (a) No Inconsistent Agreements. The Company represents, warrants, covenants
and agrees that it has not  granted,  and shall not grant,  registration  rights
with respect to Shares or any other  securities  which would  conflict  with the
terms contained in these Registration Rights.

     (b) Specific Performance.  The parties hereto acknowledge that there may be
no adequate  remedy at law if any party fails to perform any of its  obligations
hereunder and that each party may be irreparably harmed by any such failure, and
accordingly  agree that each party,  in addition to any other remedy to which it
may be  entitled  at law or in  equity,  shall be  entitled  to compel  specific
performance of the obligations of any other party under the Registration  Rights
in accordance with the terms and conditions of these Registration Rights, in any
court of the United States or any State thereof having jurisdiction.

     (c) Notices. Any notice or other communication  required or permitted to be
given hereunder  shall be deemed  effectively  given when personally  delivered,
telexed,  transmitted by facsimile or mailed by pre-paid  certified mail, return
receipt  requested,  or by  telephone  when  confirmed  in writing by one of the
preceding methods addressed as follows (as applicable):

                  If to the Company, to:

                  Celgene Corporation
                  7 Powder Horn Drive
                  Warren, NJ 07059

                                       12


<PAGE>



                  Attention: John W. Jackson
                  Telephone Number: (732) 271-1001
                  Facsimile Transmission Number: (732) 805-3931

                  with a copy to:

                  Proskauer Rose LLP
                  1585 Broadway
                  New York, NY 10036

                  Attention: Robert A. Cantone, Esq.
                  Telephone Number: (212) 969-3000
                  Facsimile Transmission Number: (212) 969-2900

                  If to Purchasers, to the Person designated by Purchaser and at
                  the  address as set forth on  Schedule I in the Note  Purchase
                  Agreement dated the date hereof between the Purchasers and the
                  Company

                  with a copy to:

                  Choate, Hall & Stewart
                  Exchange Place
                  53 State Street
                  Boston, MA 02109

                  Attention: Frank B. Porter, Jr.
                  Telephone Number: (617) 248-5000
                  Facsimile Transmission Number: (617) 248-4000

or to such other  address or number and to the attention of such other person as
either party may designate by written notice to the other party. Notice shall be
effective upon actual receipt.

     (d) Survival.  The  respective  indemnities,  agreements,  representations,
warranties and each other  provision set forth in these  Registration  Rights or
made  pursuant  hereto shall remain in full force and effect  regardless  of any
investigation  (or statement as to the results  thereof) made by or on behalf of
each Purchaser, any director, officer or partner of such Purchaser, any agent or
underwriter  or any director,  officer or partner  thereof,  or any  controlling
person of any of the  foregoing  and shall survive the transfer of the Shares by
such Purchaser.

     (e) Law  Governing.  These  Registration  Rights  shall be  governed by and
construed in accordance with the laws of the State of New York.

     (f)  Headings.  The  descriptive  headings  of  the  several  Sections  and
paragraphs of these  Registration  Rights are inserted for convenience  only, do
not constitute a part of these

                                       13


<PAGE>



Registration   Rights  and  shall  not   affect  in  any  way  the   meaning  or
interpretation of these Registration Rights.

     (g) Entire Agreement;  Amendments.  These Registration Rights and the other
writings  referred  to herein or  delivered  pursuant  hereto  which form a part
hereof  contain  the entire  understanding  of the parties  with  respect to its
subject matter.  These  Registration  Rights  supersede all prior agreements and
understandings  between the parties  with respect to its subject  matter.  These
Registration  Rights  may be  amended  and the  observance  of any term of these
Registration  Rights may be waived (either generally or in a particular instance
and either  retroactively or  prospectively)  only be a written  instrument duly
executed by the Company and each Purchaser.

     (h)  Assignment.   In  connection  with  any  permitted   transfer  of  the
Convertible  Note or any portion thereof in a principal  amount of not less than
$100,000  any  Purchaser  may  assign its  rights  hereunder  in respect of such
Convertible Note to the transferee.  Upon such assignment the transferee  shall,
insofar as the transferred  Convertible Notes are concerned,  be entitled to all
of the rights,  and be subject to all of the  obligations,  of a Purchaser under
these  Registration  Rights, and all references to such "Purchaser" herein shall
thereafter be deemed to refer to the Purchaser, or such transferee,  or both, as
the circumstances warrant.

     (i)   Counterparts.   This   agreement  may  be  executed  by  the  parties
counterparts,  each of which  shall be  deemed to be an  original,  but all such
respective counterparts shall together constitute one and the same instrument.

            [the remainder of this page is intentionally left blank]


                                       14


<PAGE>



                [Signature Page of Registration Rights Agreement]

  Agreed to and accepted as of the date referred to above.

CELGENE CORPORATION

By:
   ---------------------------------
Name: Robert J. Hugin
     -------------------------------
Title: Senior Vice President & CFO
      ------------------------------

JOHN HANCOCK MUTUAL LIFE INSURANCE COMPANY

By:
   ---------------------------------
Name:. Stephen J. Blewitt
     -------------------------------
Title: Senior Investment Officer
      ------------------------------

JOHN HANCOCK VARIABLE LIFE INSURANCE COMPANY

By:
   ---------------------------------
Name:   Stephen J. Blewitt
     -------------------------------
Title:  Senior Investment Officer
      ------------------------------

HANCOCK MEZZANINE PARTNERS L.P.
By: Hancock Mezzanine Investments LLC, its General Partner
By: John Hancock Mutual Life Insurance Company.
                                    as Investment Manager

By:
   ---------------------------------
Name:  Stephen J. Blewitt
    --------------------------------
Title: Senior Investment Officer
     -------------------------------
Exchange.3019985.2

                                                     15



                                                                    EXHIBIT 23.1

                              Accountants' Consent
The Board of Directors
Celgene Corporation:

We consent to  incorporation  by reference in the  registration  statements (No.
333-70083,  33-21462,  33-38296,  33-62510 and  333-91977)  on Form S-8 and (No.
333-02517,  333-32115, 333-38861, 333-52963, 333-87197, 333-93759 and 333-94915)
on Form S-3 of Celgene  Corporation of our report dated January 27, 2000, except
as to note 14, which is as of February 16,  2000,  relating to the  consolidated
balance sheets of Celgene Corporation and subsidiary as of December 31, 1998 and
1999,  and  the  related  consolidated  statements  of  operations,  changes  in
stockholders'  equity,  and cash  flows for each of the years in the  three-year
period ended December 31, 1999, and the related  schedule,  which report appears
in the December 31, 1999 Annual Report on Form 10-K of Celgene Corporation.


                                                            KPMG LLP

Short Hills, New Jersey
March 30, 2000



<TABLE> <S> <C>


<ARTICLE>                     5
<CIK>                         0000816284
<NAME>                        CELGENE CORPORATION
<MULTIPLIER>                                   1,000
<CURRENCY>                                     U.S. DOLLARS

<S>                             <C>
<PERIOD-TYPE>                   YEAR
<FISCAL-YEAR-END>                              DEC-31-1999
<PERIOD-START>                                 JAN-01-1999
<PERIOD-END>                                   DEC-31-1999
<EXCHANGE-RATE>                                          1
<CASH>                                          15,255,422
<SECURITIES>                                     4,271,221
<RECEIVABLES>                                    5,049,909
<ALLOWANCES>                                       121,437
<INVENTORY>                                      2,456,059
<CURRENT-ASSETS>                                   895,602
<PP&E>                                          10,979,837
<DEPRECIATION>                                   8,643,595
<TOTAL-ASSETS>                                  32,333,670
<CURRENT-LIABILITIES>                            9,300,337
<BONDS>                                         38,494,795
                                    0
                                              0
<COMMON>                                           177,036
<OTHER-SE>                                     (15,886,423)
<TOTAL-LIABILITY-AND-EQUITY>                    32,333,670
<SALES>                                         24,052,124
<TOTAL-REVENUES>                                26,209,624
<CGS>                                            2,982,713
<TOTAL-COSTS>                                   48,864,644
<OTHER-EXPENSES>                                         0
<LOSS-PROVISION>                                         0
<INTEREST-EXPENSE>                               2,838,480
<INCOME-PRETAX>                                (24,799,110)
<INCOME-TAX>                                     3,017,910
<INCOME-CONTINUING>                            (21,781,200)
<DISCONTINUED>                                           0
<EXTRAORDINARY>                                          0
<CHANGES>                                                0
<NET-INCOME>                                   (21,781,200)
<EPS-BASIC>                                          (1.28)
<EPS-DILUTED>                                        (1.28)



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