IMMUNE RESPONSE CORP
4, 1997-12-09
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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- --------                              UNITED STATES SECURITIES AND EXCHANGE COMMISSION(PRIVATE)        -----------------------------
 FORM 4                                                WASHINGTON, D.C. 20549                                   OMB APPROVAL        
- --------                                                                                               -----------------------------
/ / CHECK THIS BOX IF NO                    STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP                OMB NUMBER:       3235-0287 
    LONGER SUBJECT TO                                                                                   EXPIRES: SEPTEMBER 30, 1998 
    SECTION 16.  FORM 4 OR    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,   ESTIMATED AVERAGE BURDEN    
    FORM 5 OBLIGATIONS MAY       Section 17(a) of the Public Utility Holding Company Act of 1935 or     HOURS PER RESPONSE .... 0.5 
    CONTINUE.  SEE                       Section 30(f) of the Investment Company Act of 1940           -----------------------------
    INSTRUCTION 1(b).
(Print or Type Responses)
- ------------------------------------------------------------------------------------------------------------------------------------
<S><C>
1. Name and Address of Reporting Person*     2. Issuer Name and Ticker or Trading Symbol      6. Relationship of Reporting Person(s)
                                                                                                 to Issuer (Check all applicable)
Glavin              James          B.             The Immune Response Corporation (IMNR)        X  Director             10% Owner
                                                                                               ----                 ----
- ---------------------------------------------------------------------------------------------       Officer (give        Other
    (Last)        (First)        (Middle)    3. IRS or Social Security  4. Statement for       ----          title  ---- (specify
                                                Number of Reporting        Month/Year                        below)       below
                                                Person (Voluntary)                            -----------------  ------------------
4440 143rd Place NE                                                     November 1997
- --------------------------------------------                            --------------------- 7. Individual or Joint/Group Filing
                  (Street)                       ###-##-####            5. If Amendment,          (Check Applicable Line)
                                                                           Date of Original   ---Form filed by One Reportng Person
                                                                           (Month/Year)       ---Form filed by More than One
Bellevue          WA               98007                                                         Reporting Person
- ------------------------------------------------------------------------------------------------------------------------------------
    (City)       (State)            (Zip)        TABLE I - NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
- ------------------------------------------------------------------------------------------------------------------------------------
1. Title of Security               2. Trans-   3. Trans-     4. Securities Acquired (A)    5. Amount of     6. Owner-   7. Nature
   (Instr. 3)                         action      action        or Disposed of (D)            Securities       ship        of In-
                                      Date        Code          (Instr. 3, 4 and 5)           Beneficially     Form:       direct
                                                  (Instr. 8)                                  Owned at         Direct      Bene-
                                     (Month/                                                  End of           (D) or      ficial
                                      Day/     -------------------------------------------    Month            Indirect    Owner-
                                      Year)                               (A) or                               (I)         ship
                                                Code    V       Amount    (D)     Price       (Instr. 3        (Instr. 4) (Instr. 4)
                                                                                              and 4)
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                       11/05/97      S              5,000      D     $11.00        130.527           D
- ------------------------------------------------------------------------------------------------------------------------------------

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- ------------------------------------------------------------------------------------------------------------------------------------
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.                   (Over)
* If the form is filed by more than one reporting person, SEE Instruction 4(b)(v).                                   SEC 1474 (7-97)

                              POTENTIAL PERSONS WHO ARE TO RESPOND TO THE COLLECTION OF INFORMATION 
                              CONTAINED IN THIS FORM ARE NOT REQUIRED TO RESPOND UNLESS THE FORM 
                              DISPLAYS A CURRENTLY VALID OMB CONTROL NUMBER.

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<CAPTION>

FORM 4 (CONTINUED)          TABLE II - DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
                                   (E.G., PUTS, CALLS, WARRANTS, OPTIONS, CONVERTIBLE SECURITIES)

- ------------------------------------------------------------------------------------------------------------------------
(PRIVATE)1. Title of Derivative     2. Conver-   3. Trans-   4. Transac-   5. Number of Deriv-      6. Date Exer-
 Security (Instr. 3)                   sion or      action      tion Code     ative Securities Ac-     cisable and Ex-
                                       Exercise     Date        (Instr. 8)    quired (A) or Dis-       piration Date
                                       Price of    (Month/                    posed of (D)             (Month/Day/
                                       Deriv-       Day/                      (Instr. 3, 4, and 5)     Year)
                                       ative        Year)
                                       Security

                                                                                                    --------------------

                                                                                                     Date      Expira-
                                                             --------------------------------------  Exer-     tion
                                                                                                     cisable   Date
                                                              Code    V        (A)        (D)
<S><C>
- ------------------------------------------------------------------------------------------------------------------------
Right to Buy Common Stock Option      $8.75       05/22/97                                          see below  05/22/07*
- ------------------------------------------------------------------------------------------------------------------------
Right to Buy Common Stock             $3.25       11/23/91                                          see below  11/23/01
         Option**          
- ------------------------------------------------------------------------------------------------------------------------
Right to Buy Common Stock
         Option**                     $3.25       12/15/92                                          see below  12/15/02
- ------------------------------------------------------------------------------------------------------------------------
Right To Buy Common Stock
         Option**                     $3.25       09/19/94                                          see below  09/19/04
- ------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------

<CAPTION>

- ------------------------------------------------------------------------------------------
7. Title and Amount of Under-       8. Price   9. Number     10. Owner-     11. Nature
   lying Securities                    of         of Deriv-      ship           of In-
   (Instr. 3 and 4)                    Deriv-     ative          Form           direct
                                       ative      Securi-        of De-         Bene-
                                       Secur-     ties           rivative       ficial
                                       ity        Bene-          Secu-          Own-
                                       (Instr.    ficially       rity:          ership
                                       5)         Owned          Direct         (Instr. 4)
                                                  at End         (D) or         
                     Amount or                    of             Indi-
       Title         Number of                    Month          rect (I)
                     Shares                       (Instr. 4)     (Instr. 4)
<S><C>
- ------------------------------------------------------------------------------------------
Common Stock          6,250                       6,250           D
- ------------------------------------------------------------------------------------------
Common Stock        135,000                     135,000           D
- ------------------------------------------------------------------------------------------
Common Stock         75,000                      75,000           D
- ------------------------------------------------------------------------------------------
Common Stock         86,250                      86,250           D
- ------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------

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- ------------------------------------------------------------------------------------------
Explanation of Responses:

*  Options vest fully one-year from date of grant.
** Options were repriced on April 19, 1995, with a one-year blackout period, and are exempt pursuant to Rule 16(b)3f. All options 
   vest daily over a four year period beginning on the date of grant.




                                                                                  -----------------------------------  -----------
**Intentional misstatements or omissions of facts constitute                        **Signature of Reporting Person       Date
  Federal Criminal Violations.  SEE 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed.
      If space provided is insufficient, SEE Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained 
in this form are not required to respond unless the form displays a currently 
valid OMB Number.
                                                                                                                              Page 2
                                                                                                                     SEC 1474 (7-97)
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