ADVANCED POLYMER SYSTEMS INC /DE/
11-K, 1997-03-31
PLASTIC MATERIALS, SYNTH RESINS & NONVULCAN ELASTOMERS
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549



                                    Form 11-K


(Mark One)

( X )    Annual report pursuant to Section 15(d) of the Securities Exchange Act
         of 1934 (Fee Required)
         For the fiscal year ended December 31, 1996 or
                                   -----------------


(  )     Transition report pursuant to Section 15(d) of the Securities Exchange
         Act of 1934 (No Fee Required)         
         For the transition period from ____ to ____


Commission File Number 0-16109








                         ADVANCED POLYMER SYSTEMS, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN











                         ADVANCED POLYMER SYSTEMS, INC.
                                3696 Haven Avenue
                         Redwood City, California 94063
                            Telephone: (415) 366-2626


<PAGE>



Financial Statement and Exhibits
<TABLE>
                                                   ADVANCED POLYMER SYSTEMS, INC.
                                                SALARY REDUCTION PROFIT SHARING PLAN

                                                  STATEMENT OF FINANCIAL CONDITION
                                                        at December 31, 1996
<CAPTION>
                              Nationwide    Nationwide                                Nationwide       Warburg   
                                American          Bond     Templeton      Fidelity     Twentieth        Pincus   
                                Balanced       Fund of       Foreign      Magellan       Century      Emerging   
                                    Fund       America          Fund          Fund        Growth        Growth   
                              ----------    ----------    ----------    ----------    ----------    ----------   
<S>                           <C>           <C>           <C>           <C>           <C>           <C>          
ASSETS:

Cash account                  $        0    $        0    $        0    $        0    $        0    $        0   
Investments, at market           393,452       182,926             0       241,543       617,549             0   
Participant loans                      0             0             0             0             0             0   
Contributions receivable           4,066         1,721         1,832         5,118        5 ,930         1,205   
                              ----------    ----------    ----------    ----------    ----------    ----------   


TOTAL ASSETS                  $  397,518    $  184,647    $    1,832    $  246,661    $  623,479    $    1,205   
                              ==========    ==========    ==========    ==========    ==========    ==========   
                              
LIABILITIES:

Distribution payable          $        0    $        0    $        0    $        0    $        0    $        0   
                              ----------    ----------    ----------    ----------    ----------    ----------   

TOTAL LIABILITIES                      0             0             0             0             0             0   

PLAN EQUITY:

Salary reduction accounts        332,016       154,357             0       195,405       522,137             0   
Employer matching accounts        65,502        30,290         1,832        51,256       101,342         1,205   
                              ----------    ----------    ----------    ----------    ----------    ----------   


    TOTAL EQUITY                 397,518       184,647         1,832       246,661       623,479         1,205   

TOTAL LIABILITIES
    AND EQUITY                $  397,518    $  184,647    $    1,832    $  246,661    $  623,479    $    1,205   
                              ==========    ==========    ==========    ==========    ==========    ==========   
</TABLE>

                            Nationwide                                          
                              Guaranty           APS                       Total
                           and Savings        Common   Participant           All
                                  Fund         Stock         Loans         Funds
                            ----------    ----------    ----------    ----------
                                                                                
ASSETS:                                                                         
                                                                                
Cash account                $    5,887    $        0    $        0    $    5,887
Investments, at market         390,911        67,489             0     1,893,870
Participant loans                    0             0        11,128        11,128
Contributions receivable         3,787         1,378             0        25,037
                            ----------    ----------    ----------    ----------
                                                                                
                                                                                
TOTAL ASSETS                $  400,585    $   68,867    $   11,128    $1,935,922
                            ==========    ==========    ==========    ==========
                                                                                
LIABILITIES:                                                                    
                                                                                
Distribution payable        $        0    $        0    $        0    $        0
                            ----------    ----------    ----------    ----------
                                                                                
TOTAL LIABILITIES                    0             0             0             0
                                                                                
PLAN EQUITY:                                                                    
                                                                                
Salary reduction accounts      323,798        55,454        11,128     1,594,295
Employer matching accounts      76,787        13,413             0       341,627
                            ----------    ----------    ----------    ----------
                                                                                
                                                                                
    TOTAL EQUITY               400,585        68,867        11,128     1,935,922
                                                                                
TOTAL LIABILITIES                                                               
    AND EQUITY              $  400,585    $   68,867    $   11,128    $1,935,922
                            ==========    ==========    ==========    ==========
                                                                                
See accompanying notes.

<PAGE>

Financial Statement and Exhibits
<TABLE>


                                                   ADVANCED POLYMER SYSTEMS, INC.
                                                SALARY REDUCTION PROFIT SHARING PLAN

                                                  STATEMENT OF FINANCIAL CONDITION
                                                        at December 31, 1995
<CAPTION>

                              Nationwide  Nationwide              Nationwide    Nationwide
                                American        Bond    Fidelity   Twentieth      Guaranty         APS                      Total
                                Balanced     Fund of    Magellan     Century   and Savings      Common   Participant          All
                                    Fund     America        Fund      Growth          Fund       Stock         Loans        Funds
                           ------------- ----------- ----------- -------------------------------------  ------------  -----------
<S>                             <C>         <C>         <C>         <C>           <C>          <C>            <C>      <C>       
ASSETS:

Cash account                          $0          $0          $0          $0        $7,114          $0            $0       $7,114
Investments, at market           293,031     156,631     122,349     491,553       352,975      33,808             0    1,450,347
Participant loans                      0           0           0           0             0           0         6,531        6,531
Contributions receivable           3,458       2,570       8,911       6,582         5,583       1,254             0       28,358
                                --------    --------    --------    --------      --------     -------        ------   ----------
TOTAL ASSETS                    $296,489    $159,201    $131,260    $498,135      $365,672     $35,062        $6,531   $1,492,350
                                ========    ========    ========    ========      ========     =======        ======   ==========


LIABILITIES:

Distributions payable                 $0          $0          $0          $0            $0          $0            $0           $0
                                --------    --------    --------    --------      --------     -------        ------   ----------

TOTAL LIABILITIES                     $0          $0          $0          $0            $0          $0            $0           $0


PLAN EQUITY:

Salary reduction accounts        250,543     135,232     104,974     420,447       301,560      28,418         6,531    1,247,705
Employer matching accounts        45,946      23,969      26,286      77,688        64,112       6,644             0      244,645
                                --------    --------    --------    --------      --------     -------        ------   ----------
                             
TOTAL EQUITY                     296,489     159,201     131,260     498,135       365,672      35,062         6,531    1,492,350

TOTAL LIABILITIES
    AND EQUITY                  $296,489    $159,201    $131,260    $498,135      $365,672     $35,062        $6,531   $1,492,350
                                ========    ========    ========    ========      ========     =======        ======   ==========
<FN>
See accompanying notes.
</FN>
</TABLE>


<PAGE>

<TABLE>


                                                   ADVANCED POLYMER SYSTEMS, INC.

                                                SALARY REDUCTION PROFIT SHARING PLAN

                                           STATEMENT OF INCOME AND CHANGES IN PLAN EQUITY
                                                for the year ended December 31, 1996
<CAPTION>

                                   Nationwide      Nationwide                                     Nationwide 
                                     American            Bond       Templeton       Fidelity       Twentieth 
                                     Balanced         Fund of         Foreign       Magellan         Century 
                                         Fund         America            Fund           Fund          Growth 
                                  -----------     -----------     -----------    -----------     ----------- 
<S>                               <C>             <C>             <C>            <C>             <C>
Investment income:
    Interest and dividends        $         0     $         0     $         0    $         0     $         0 
                                  -----------     -----------     -----------    -----------     ----------- 


    Total investment income                 0               0               0              0               0 
                                  -----------     -----------     -----------    -----------     ----------- 


Net realized and unrealized
gains on investments                   37,966           8,749               0         19,348          68,997          
                                  -----------     -----------     -----------    -----------     ----------- 


Contributions:
    Employee                           53,948          23,696               0         88,164          77,480 
    Employer                           16,724           7,582           1,832         27,347          24,837 
    Rollovers                           5,058              14               0          4,936          11,964 
                                  -----------     -----------     -----------    -----------     ----------- 

                                                                                                             

    Total contributions                75,730          31,292           1,832        120,447         114,281 
                                  -----------     -----------     -----------    -----------     ----------- 

Withdrawals, transfers and
    distributions:
    Member accounts
      withdrawn &
      distributed                     (14,487)        (10,488)              0        (23,534)        (56,696)
    Member accounts
      transferred-in (out)              1,820          (4,107)              0           (860)         (1,238)
                                  -----------     -----------     -----------    -----------     ----------- 

                                                                                                             
Net withdrawals, transfers and
    distributions                     (12,667)        (14,595)              0        (24,394)        (57,934)
                                  -----------     -----------     -----------    -----------     ----------- 


Net increase in plan equity
                                      101,029          25,446           1,832        115,401         125,344 

Plan equity:
    Beginning of the year             296,489         159,201               0        131,260         498,135 
                                  -----------     -----------     -----------    -----------     ----------- 

    End of the year               $   397,518     $   184,647     $     1,832    $   246,661     $   623,479 
                                  ===========     ===========     ===========    ===========     =========== 

</TABLE>
<TABLE>
<CAPTION>


                                      Warburg      Nationwide                                                  
                                       Pincus        Guaranty            APS                           Total 
                                     Emerging     and Savings          Common    Participant             All 
                                       Growth            Fund           Stock          Loans           Funds 
                                  -----------     -----------     -----------    -----------     ----------- 
<S>                              <C>             <C>             <C>             <C>             <C>        
Investment income:
 Interest and dividends          $         0     $    19,981     $         0     $       781     $    20,762
                                 -----------     -----------     -----------     -----------     -----------
    Total investment income                0          19,981               0             781          20,762
                                 -----------     -----------     -----------     -----------     -----------
                                                                                                               
Net realized and unrealized                                                                                    
gains on investments                       0               0          13,150               0         148,210   
                                 -----------     -----------     -----------     -----------     -----------   
Contributions:                                                                                              
    Employee                               0          61,207          16,439               0         320,934   
    Employer                           1,205          20,393           5,511               0         105,431   
    Rollovers                              0           2,873               0               0          24,845   
                                 -----------     -----------     -----------     -----------     -----------   
     Total contributions               1,205          84,473          21,950               0         451,210
                                 -----------     -----------     -----------     -----------     -----------   
                                                                                                               
Withdrawals, transfers and                                                                                     
    distributions:                                                                                             
    Member accounts                                                                                            
      withdrawn &                                                                                              
      distributions                        0         (66,590)         (4,815)              0        (176,610)  
    Member accounts                                                                                            
      transferred-in (out)                 0          (2,951)          3,520           3,816               0   
                                 -----------     -----------     -----------     -----------     -----------   
Net withdrawals, transfers and
 distributions                             0         (69,541)         (1,295)          3,816        (176,610)  
                                 -----------     -----------     -----------     -----------     -----------  
Net increase in plan equity            1,205          34,913          33,805           4,597         443,572   
                                                                                                               
Plan equity:                                                                                                   
    Beginning of the year                  0         365,672          35,062           6,531       1,492,350   
                                 -----------     -----------     -----------     -----------     -----------   
                                                                                                               
    End of the year              $     1,205     $   400,585     $    68,867     $    11,128     $ 1,935,922   
                                 ===========     ===========     ===========     ===========     ===========   
                                    
<FN>
See accompanying notes                 
</FN>
</TABLE>
                               
<PAGE>

<TABLE>

                                                   ADVANCED POLYMER SYSTEMS, INC.
                                                SALARY REDUCTION PROFIT SHARING PLAN

                                           STATEMENT OF INCOME AND CHANGES IN PLAN EQUITY
                                                for the year ended December 31, 1995

<CAPTION>

                              Nationwide  Nationwide              Nationwide    Nationwide
                                American        Bond    Fidelity   Twentieth      Guaranty         APS                      Total
                                Balanced     Fund of    Magellan     Century   and Savings      Common   Participant          All
                                    Fund     America        Fund      Growth          Fund       Stock         Loans        Funds
                              ----------   ---------  ----------  ----------    ----------  ----------  ------------   ----------

<S>                             <C>         <C>         <C>         <C>           <C>          <C>             <C>     <C>       
Investment income:
    Interest and dividends            $0          $0          $0          $0       $18,162          $0          $753      $18,915
                              ----------   ---------  ----------  ----------    ----------  ----------  ------------   ----------
                          
    Total investment income            0           0           0           0        18,162           0           753       18,915
                              ----------   ---------  ----------  ----------    ----------  ----------  ------------   ----------
                          
Net realized and unrealized
gains on investments              46,387      21,690      26,872      71,238             0       5,247             0      171,434
                              ----------   ---------  ----------  ----------    ----------  ----------  ------------   ----------
                          
Contributions:
    Employee                      43,172      19,728      57,220      61,994        66,221      11,399             0      259,734
    Employer                      12,777       7,237      20,869      21,815        22,760       4,036             0       89,494
    Rollovers                      3,458       3,270       2,417      18,285        16,689           0             0       44,119
                              ----------   ---------  ----------  ----------    ----------  ----------  ------------   ----------
                          
    Total contributions           59,407      30,235      80,506     102,094       105,670      15,435             0      393,347
                              ----------   ---------  ----------  ----------    ----------  ----------  ------------   ----------
                          
Withdrawals, transfers and
    distributions:
    Member accounts
      withdrawn & distributed    (12,848)    (20,558)     (7,413)    (57,690)      (22,723)     (2,885)            0     (124,117)
    Member accounts
      transferred-in (out)         8,919      (9,411)      7,923     (18,312)       20,840      (5,629)       (4,330)           0
                              ----------   ---------  ----------  ----------    ----------  ----------  ------------   ----------
                          
Net withdrawals, transfers and
    distributions                 (3,929)    (29,969)        510     (76,002)       (1,883)     (8,514)       (4,330)    (124,117)
                              ----------   ---------  ----------  ----------    ----------  ----------   -----------   ----------

Net increase (decrease) in plan
    equity                       101,865      21,956     107,888      97,330       121,949      12,168        (3,577)     459,579

Plan equity:
    Beginning of the year        194,624     137,245      23,372     400,805       243,723      22,894        10,108    1,032,771
                              ----------    --------   ---------    --------    ----------  ----------   -----------  -----------

    End of the year             $296,489    $159,201    $131,260    $498,135      $365,672     $35,062        $6,531   $1,492,350
                               =========    ========   =========    ========    ==========   =========   ===========  ===========
<FN>

See accompanying notes.
</FN>
</TABLE>

<PAGE>

<TABLE>

                                                   ADVANCED POLYMER SYSTEMS, INC.
                                                SALARY REDUCTION PROFIT SHARING PLAN

                                           STATEMENT OF INCOME AND CHANGES IN PLAN EQUITY
                                                for the year ended December 31, 1994

<CAPTION>

                                  Nationwide    Nationwide                 Nationwide    Nationwide
                                    American          Bond      Fidelity    Twentieth      Guaranty
                                    Balanced       Fund of      Magellan      Century   and Savings
                                        Fund       America          Fund       Growth          Fund
                                 -----------   -----------   -----------  -----------   -----------
<S>                              <C>           <C>           <C>          <C>           <C>        
Investment income:
    Interest and dividends       $         0   $         0   $         0  $         0   $    11,201
                                 -----------   -----------   -----------  -----------   -----------

    Total investment income                0             0             0            0        11,201
                                 -----------   -----------   -----------  -----------   -----------

Net realized and unrealized
gains (losses) on investments         (3,954)       (8,797)          449       (8,297)            0
                                 -----------   -----------   -----------  -----------   -----------


Contributions:
    Employee                          47,870        22,930         7,831       81,238        54,366
    Employer                          11,858         6,741         1,396       20,285        12,505
    Rollovers                              0             0             0            0             0
                                 -----------   -----------   -----------  -----------   -----------

    Total contributions               59,728        29,671         9,227      101,523        66,871
                                 -----------   -----------   -----------  -----------   -----------

Withdrawals, transfers and
    distributions:
    Member accounts
      withdrawn                     (133,785)      (31,598)            0     (217,652)      (92,441)
    Distributions                          0             0             0            0        (2,005)
    Member accounts
      transferred-in (out)           (27,892)       18,819        13,696      (43,724)       45,804
                                 -----------   -----------   -----------  -----------   -----------

Net withdrawals, transfers and
    distributions                   (161,677)      (12,779)       13,696     (261,376)      (48,642)
                                 -----------   -----------   -----------  -----------   -----------

Net increase (decrease) in plan
    equity                          (105,903)        8,095        23,372     (168,150)       29,430

Plan equity:
    Beginning of the year            300,527       129,150             0      568,955       214,293
                                 -----------   -----------   -----------  -----------   -----------

    End of the year              $   194,624   $   137,245   $    23,372  $   400,805   $   243,723
                                 ===========   ===========   ===========  ===========   ===========
</TABLE>




                                                                           
                                           APS                       Total 
                                        Common   Participant           All 
                                         Stock         Loans         Funds 
                                   -----------   -----------   ----------- 
                                                                           
Investment income:                                                         
    Interest and dividends         $         0   $       966   $    12,167 
                                   -----------   -----------   ----------- 
                                                                           
    Total investment income                  0           966        12,167 
                                   -----------   -----------   ----------- 
                                                                           
Net realized and unrealized                                                
gains (losses) on investments           (3,460)            0       (24,059)
                                   -----------   -----------   ----------- 
                                                                           
                                                                           
Contributions:                                                             
    Employee                             9,375             0       223,610 
    Employer                             2,381             0        55,166 
    Rollovers                                0             0             0 
                                   -----------   -----------   ----------- 
                                                                           
    Total contributions                 11,756             0       278,776 
                                   -----------   -----------   ----------- 
                                                                           
Withdrawals, transfers and                                                 
    distributions:                                                         
    Member accounts                                                        
      withdrawn                        (21,528)            0      (497,004)
    Distributions                            0             0        (2,005)
    Member accounts                                                        
      transferred-in (out)              (3,149)       (3,554)            0 
                                   -----------   -----------   ----------- 
                                                                           
Net withdrawals, transfers and                                             
    distributions                      (24,677)       (3,554)     (499,009)
                                   -----------   -----------   ----------- 
                                                                           
Net increase (decrease) in plan                                            
    equity                             (16,381)       (2,588)     (232,125)
                                                                           
Plan equity:                                                               
    Beginning of the year               39,275        12,696     1,264,896 
                                   -----------   -----------   ----------- 
                                                                           
    End of the year                $    22,894   $    10,108   $ 1,032,771 
                                   ===========   ===========   =========== 

See accompanying notes.

<PAGE>

                         ADVANCED POLYMER SYSTEMS, INC.

                      SALARY REDUCTION PROFIT SHARING PLAN
                          Notes to Financial Statements
                        December 31, 1996, 1995 and 1994


1.  DESCRIPTION OF THE PLAN

          The following description of the Advanced Polymer Systems, Inc. Salary
Reduction  Profit  Sharing Plan (the "401(k) Plan" or the "Plan")  provides only
general  information.  Members should refer to the 401(k) Plan document for more
complete information.

          (a) General

          The  401(k)  Plan  is a  defined  contribution  plan  covering  active
employees of Advanced  Polymer  Systems,  Inc.  ("APS" or the "Company") and its
subsidiaries.  Any employee who is at least 21 years old is eligible to become a
voluntary member of the 401(k) Plan immediately upon employment.

          The  401(k)  Plan  is  subject  to  the  provisions  of  the  Employee
Retirement Income Security Act of 1974 ("ERISA").

          (b) Contributions - Employee

          Eligible  domestic  employees may  contribute up to 15% of their total
compensation  for each calendar  year,  limited to $9,500 in 1996, and $9,240 in
1995 and 1994 (the "Employee Contribution").

          (c) Contributions - Employer

          For the 1994 Plan year, the Company made matching  contributions equal
to 50% of each  member's  Employee  Contribution  during  the Plan  year up to a
maximum amount equal to the lesser of 1.5% of each member's annual compensation,
or $1,000 per calendar year (the "Employer Matching Contribution").  The Company
may also contribute  additional  discretionary  amounts as it may determine (the
"Employer Discretionary Contribution").  No Employer Discretionary Contributions
have been made to the Plan  since its  inception.  Beginning  with the 1995 Plan
year,  the Plan  document  was amended to change the maximum  Employer  Matching
Contribution to 3% of the participants'  annual gross  compensation,  limited to
$4,500.

          (d) Members' Accounts

          The  Company  maintains  separate  Employee   Contribution   accounts,
Employer Matching Contribution accounts and Employer Discretionary  Contribution
accounts for each member. Contributions are credited to the member accounts each
bi-weekly  payroll period.

          In 1994,  the plan  trustees  added the Fidelity  Magellan Fund to the
investment options offered to the participants. In 1996, the plan trustees added
the Warburg Pincus  Emerging  Growth Fund and the Templeton  Foreign Fund to the
investment  options offered to the participants.  Each member may elect from the
following investment options for his/her Employee Contribution accounts:

          Company Common Stock:

The  Common  Stock of APS will be  purchased  by the  401(k)  Plan's  investment
manager for the member in a market  transaction at the then current market price
as quoted on the NASDAQ National Market System.  Each member may elect to invest
up to 10% of his/her Employee  Contributions and Employer Matching Contributions
in this option.

<PAGE>

          Warburg Pincus Emerging Growth:

A mutual fund seeking  capital  appreciation  by  investing  primarily in common
stock of small and  medium  size  companies  that  show  positive  earnings  and
prospects of achieving significant gains in a relatively short time period.

          Templeton Foreign:

A mutual fund seeking  capital growth by investing in stock and debt  securities
of companies and governments outside of the United States.

          Fidelity Magellan Fund:

A mutual fund seeking capital growth by investing primarily in common stocks and
securities  convertible into common stock of domestic and foreign  multinational
issuers of all sizes.

          Nationwide Twentieth Century Growth:

A mutual fund seeking  capital  growth by investing  primarily in common  stocks
that are considered by fund management to have better-than-average prospects for
appreciation.

          Nationwide American Balanced Fund:

A mutual fund seeking conversion of capital, current income and long-term growth
of both  capital  and income  through  investments  in  stocks,  bonds and other
fixed-income securities.

          Nationwide Bond Fund of America:

A mutual fund seeking to provide  shareholders as high a level of current income
as is  consistent  with the  preservation  of capital by investing  primarily in
bonds such as marketable corporate debt securities,  U.S. Government securities,
mortgage related securities and cash or money market instruments.

          Nationwide Guaranty and Savings Fund:

Money market funds invested in short-term  securities  with a guaranteed rate of
5.85% in 1996, 6.1% in 1995 and 5.6% in 1994.

          Members may change their investment  options at specified dates during
the Plan year as set forth in the 401(k) Plan document. Income from the selected
investments of 401(k) Plan assets is allocated  quarterly in the proportion that
each member's  investment option balance bears to the cumulative balance of each
investment option.

          (e) Vesting

          The 401(k) Plan provides that the allocated contribution and income of
both the Employee  Contribution  account and the Employer Matching  Contribution
account are immediately and fully vested.  Employer Discretionary  Contributions
become  vested  over a  period  of 6 years  in  accordance  with  the  following
schedule:

<PAGE>

                       Years of Service                        Vested Percentage
                       ----------------                        -----------------
                       Less than 1                                    0%
                       1                                             10%
                       2                                             20%
                       3                                             40%
                       4                                             60%
                       5                                             80%
                       6 or more                                    100%


          (f) Withdrawal of Member Accounts

          The full  amounts  in a  member's  accounts,  other  than the  amounts
constituting  Employer  Discretionary  Contributions,  will be distributed  upon
retirement (at 62 years of age or if later, the employee's fifth  anniversary of
employment with the Company), death, or permanent disability of the member.

          If a member's  employment with the Company  terminates prior to normal
retirement (as defined above) for any reason other than death or disability, the
participant  will be entitled to a  distribution  equal to the vested portion of
his/her accounts.

          Members  should refer to the 401(k) Plan  document for a more complete
description of procedures and calculations for the withdrawal of accounts.

          (g) Trustees

          The  401(k)  Plan  is  administered  by  the  Company.  A  Trustee  is
responsible  for investing  the assets of the Plan which are held in Trust.  The
current  trustee is  Michael  O'Connell,  Chief  Financial  Officer of  Advanced
Polymer Systems, Inc.

          The Trustee  has  retained  CMG  Consulting,  Inc.  ("CMG") to provide
recordkeeping  services to the 401(k) Plan.  CMG also invests Plan assets in the
various mutual funds offered by Nationwide Life Insurance.

          Members of the Board of Directors and employees of the Company serving
as Trustees  receive no additional  compensation for services in connection with
the administration of the 401(k) Plan.

          (h) Participant Loans

          Participants are allowed to borrow from the Plan assets. The Plan will
allow a  participant  to borrow up to the lesser of 50% of his/her  vested  Plan
balance  or  $50,000.  The loan,  secured  by the  vested  Plan  balance  of the
participant,  is  repayable in  installments  over a period up to 5 years at the
prime rate plus 2%. The term of the loan can be  extended  for more than 5 years
if the loan is used to purchase the principal dwelling of the participant.


2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

          (a) Investment Valuation

          The value of  investments  is based upon quoted  market  values on the
last business day of the year.

          (b) Security Transactions and Investment Income

          Securities  transactions  are  recorded  on a trade  date  basis.  The
difference between cost and market value of investments at the beginning and end
of the period is reported as  unrealized  appreciation  or  depreciation  in the
market value of investments using the average cost method.

<PAGE>

          (c) Expenses of the 401(k) Plan

          Reasonable  fees  and  expenses  incurred  in  the  establishment  and
administration  of the 401(k) Plan,  and reasonable  compensation  of attorneys,
accountants,  investment  managers,  actuaries,  consultants  or expenses of the
Trustees  or any agent of the  Trustees if not  employed by the Company  will be
paid out of the assets of the 401(k) Plan, except to the extent that the Company
pays such expenses directly.  For the three-year period ended December 31, 1996,
all such expenses were paid by the Company.

          (d) Forfeited Funds

          If a Participant  terminates  employment  with APS prior to completing
six  years  of  service,   the  unvested  portion  of  such  member's   Employer
Discretionary  Contribution  account will be forfeited and  allocated  among the
remaining participants in the 401(k) Plan.


          (e) Basis of Accounting

          The  financial  statements  are  prepared  on  the  accrual  basis  of
accounting.


          (f)  Use of Estimates


          The  preparation of financial  statements in conformity with generally
accepted accounting principles requires the plan administrator to make estimates
and assumptions that affect the amounts reported in the financial statements and
related  notes to financial  statements.  Changes in such  estimates  may affect
amounts reported in future periods.


3. INVESTMENTS

          Investments  of the 401(k) Plan at market  value as of December 31 are
summarized as follows:

                                        1996                      1995
                                        ----                      ----

Nationwide American Balanced Fund     $393,452                  $293,031
Nationwide Bond Fund of America        182,926                   156,631
Fidelity Magellan Fund                 241,543                   122,349
Nationwide Twentieth Century Growth    617,549                   491,553
Nationwide Guaranty and Savings Fund   390,911                   352,975
APS Common Stock                        67,489                    33,808


<PAGE>


          Investment  option  elections  of the  members of the  401(k)  Plan at
December 31 are summarized as follows:

                                                   Number of Participants
                                                  1996                1995
                                                  ----                ----
Nationwide American Balanced Fund                   46                  40
Nationwide Bond Fund of America                     28                  29
Fidelity Magellan Fund                              44                  33
Nationwide Twentieth Century Growth                 53                  49
Nationwide Guaranty and Savings Fund                43                  43
APS Common Stock                                    48                  39


4. INCOME TAXES

          APS  received a  favorable  determination  from the  Internal  Revenue
Service  ("IRS")  stating that the 401(k) Plan is qualified under Section 401 of
the Internal Revenue Code ("Code") as amended, and is exempt from federal income
taxation under Section 501 of the Code. Accordingly, the financial statements do
not  contain a  provision  for income  taxes.  The  continued  qualification  is
dependent on the Plan's future operation.

          Members  do  not  become  subject  to  income  taxes  as a  result  of
participation  in the  401(k)  Plan until  assets in the  members' accounts  are
distributed. Under certain circumstances, a distribution from the 401(k) Plan is
subject to income tax as ordinary income.


5. PLAN TERMINATION

          Although it has not  expressed  any intent to do so, APS has the right
to  terminate  the 401(k)  Plan at any time.  In the event of  termination,  all
accounts  will become fully  vested,  and all net assets will be  allocated  and
distributed to the members based on their respective account balances.

<PAGE>


6. SCHEDULE OF MARKETABLE SECURITIES

          Marketable  Securities  of the 401(k)  Plan at  December  31, 1996 and
1995, inclusive of contributions receivable, consisted of the following:

                                                                          Market
 Units                 Description                  Cost                  Value
- ------                 -----------               --------                 ------

1996
- ----
 181,182  Nationwide American Balanced Fund      $274,841              $397,518
  85,433  Nationwide Bond Fund of America         140,188               184,647
   1,346  Templeton Foreign Fund                    1,832                 1,832
 123,698  Fidelity Magellan Fund                  199,992               246,661
 145,470  Nationwide Twentieth Century Growth     435,146               623,479
 349,325  Nationwide Guaranty and Savings Fund    332,773               400,585
   1,033  Warburg Pincus Emerging Growth            1,205                 1,205
   9,032  APS Common Stock                         52,524                68,867
                                               ----------           -----------
                                               $1,438,501            $1,924,794

1995
- ----
 153,015  Nationwide American Balanced Fund      $211,711              $296,489
  78,610  Nationwide Bond Fund of America         123,491               159,201
  73,602  Fidelity Magellan Fund                  103,939               131,260
 133,760  Nationwide Twentieth Century Growth     378,666               498,135
 337,790  Nationwide Guaranty and Savings Fund    317,841               365,672
   6,375  APS Common Stock                         31,869                35,062
                                               ----------           -----------
                                               $1,167,517            $1,485,819

<PAGE>



                          INDEPENDENT AUDITORS' REPORT



The Board of Directors and Shareholders of Advanced  Polymer  Systems,  Inc. and
the Trustees and  Participants  in the Advanced  Polymer  Systems,  Inc.  Salary
Reduction Profit Sharing Plan:

          We have audited the accompanying  statements of financial condition of
the Advanced  Polymer  Systems,  Inc. Salary Reduction Profit Sharing Plan as of
December 31, 1996 and 1995, and the related  statements of income and changes in
Plan equity for each of the years in the  three-year  period ended  December 31,
1996.  These  financial   statements  are  the   responsibility  of  the  Plan's
management.  Our  responsibility  is to express  an  opinion on these  financial
statements based on our audits.

          We conducted our audits in accordance with generally accepted auditing
standards.  Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement.  An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements.  An audit also includes
assessing the  accounting  principles  used and  significant  estimates  made by
management,  as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.

          In our opinion,  the  financial  statements  referred to above present
fairly, in all material respects, the financial position of the Advanced Polymer
Systems,  Inc. Salary  Reduction Profit Sharing Plan as of December 31, 1996 and
1995,  and the results of its operations and its changes in Plan equity for each
of the years in the  three-year  period ended  December 31, 1996,  in conformity
with generally accepted accounting principles.



                                                           KPMG Peat Marwick LLP


San Francisco, California
March 5, 1997


<PAGE>


Exhibits.

          23 Consent of Independent Certified Public Accountants


SIGNATURES

          Pursuant to the  requirements of the Securities  Exchange Act of 1934,
the trustees (or other  persons who  administer  the plan) have duly caused this
annual report to be signed by the undersigned thereunto duly authorized.

                         Advanced Polymer Systems, Inc.
                      Salary Reduction Profit Sharing Plan
                      ------------------------------------






Date:     March 26, 1997                            /s/ Michael O'Connell
          ----------------                          -------------------------
                                                    Michael O'Connell
                                                    Trustee


<PAGE>


                                  EXHIBIT INDEX


                             Form 11-K Annual Report


                         ADVANCED POLYMER SYSTEMS, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

23 Consent of Independent Public Accountants






EXHIBIT 23
CONSENT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS

The Board of Directors and Shareholders of Advanced  Polymer  Systems,  Inc. and
the Trustees and  Participants  in the Advanced  Polymer  Systems,  Inc.  Salary
Reduction Profit Sharing Plan:


We consent to  incorporation  by reference in the  Registration  Statement  (No.
33-29084) on Form S-8 of the Advanced  Polymer  Systems,  Inc. Salary  Reduction
Profit Sharing Plan of our report dated March 5, 1997 relating to the statements
of financial  condition of the Advanced Polymer  Systems,  Inc. Salary Reduction
Profit Sharing Plan as of December 31, 1996 and 1995 and the related  statements
of income  and  changes in Plan  equity for each of the years in the  three-year
period ended  December 31, 1996,  which report  appears in the December 31, 1996
annual  report  on Form  11-K  of the  Advanced  Polymer  Systems,  Inc.  Salary
Reduction Profit Sharing Plan.



                                                           KPMG Peat Marwick LLP



San Francisco, California
March 26, 1997



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