ADVANCED POLYMER SYSTEMS INC /DE/
DEF 14A, 1997-04-30
PLASTIC MATERIALS, SYNTH RESINS & NONVULCAN ELASTOMERS
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                            SCHEDULE 14A INFORMATION

           PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                      EXCHANGE ACT OF 1934 (AMENDMENT NO. )

Filed by the Registrant /X/

Filed by a Party other than the registrant /  /

Check the appropriate box:

<TABLE>
<S>                                                <C>
/ / Preliminary Proxy Statement                    / / Confidential, for Use of the Commission
                                                   Only (as permitted by Rule 14a-6(e)(2))
/X/ Definitive Proxy Statement
/ / Definitive Additional Materials
/ / Soliciting Material Pursuant to sec.240.14a-11(c) or sec.240.14a-12
</TABLE>
                ------------------------------------------------
                         ADVANCED POLYMER SYSTEMS, INC.
                ------------------------------------------------
                (Name of Registrant as Specified in Its Charter)

    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

/X/     $125  per  Exchange  Act  Rules  0-11(c)(1)(ii),   or  14a-6(i)(1),   or
        14a-6(i)(2) or Item 22(a)(2) of Schedule 14A.

/ /     $500 per each party to the  controversy  pursuant to  Exchange  Act Rule
        14a-6(i)(3).

/ /     Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
        (1)  Title of each class of securities to which transaction applies:
        (2)  Aggregate number of securities to which transaction applies:
        (3)  Per unit price or other  underlying  value of transaction  computed
             pursuant to  Exchange  Act Rule 0-11 (Set forth the amount on which
             the filing fee is calculated and state how it was determined):
        (4)  Proposed maximum aggregate value of transaction:
        (5)  Total fee paid:

/ /     Fee paid previously with preliminary materials.

/ /     Check box if any part of the fee is offset as provided  by Exchange  Act
        Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
        paid previously.  Identify the previous filing by registration statement
        number, or the Form or Schedule and the date of its filing.
        (1)  Amount Previously Paid:
        (2)  Form, Schedule or Registration Statement No.:
        (3)  Filing Party:
        (4)  Date Filed:



<PAGE>

                        ADVANCED POLYMER SYSTEMS, INC.

                   NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD JUNE 18, 1997


To the Stockholders of Advanced Polymer Systems, Inc.:


     The Annual Meeting of Stockholders of Advanced Polymer  Systems,  Inc. (the
"Company")  will be held at the  Park  Hyatt  Hotel,  333  Battery  Street,  San
Francisco,  California,  on June 18,  1997,  at 10:00 a.m.  local time,  for the
following purposes:

          1. To elect  eight  directors  to hold  office  until the next  annual
     meeting of stockholders and until their successors are elected.

          2. To approve an amendment to the  Company's  1992 Stock Plan to limit
     the number of shares  with  respect to which  options  may be granted to no
     more than 250,000 shares to any one participant in any one-year period.

          3. To approve the Company's 1997 Employee Stock Purchase Plan covering
     400,000 shares issuable under the plan.

          4. To transact  such other  business  as properly  may come before the
     meeting, or any adjournments or postponements of the meeting.

     Only stockholders of record at the close of business on April 23, 1997, are
entitled  to notice of,  and to vote at, the  meeting  and any  adjournments  or
postponements of the meeting.


                              BY ORDER OF THE BOARD OF DIRECTORS,


                              Julian N. Stern, Secretary

Redwood City, California
May 19, 1997

                               -- IMPORTANT --

   WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING IN PERSON, PLEASE SIGN AND
     RETURN THE ENCLOSED PROXY AS SOON AS POSSIBLE IN THE ENCLOSED POSTPAID
                    ENVELOPE. THANK YOU FOR ACTING PROMPTLY.


                                        1


<PAGE>


                        ADVANCED POLYMER SYSTEMS, INC.
                              3696 HAVEN AVENUE
                        REDWOOD CITY, CALIFORNIA 94063
                                (415) 366-2626

                               PROXY STATEMENT


     The enclosed  proxy is  solicited on behalf of the Board of Directors  (the
"Board") of Advanced Polymer Systems, Inc. ("APS" or the "Company"),  a Delaware
corporation.   The  proxy  is  solicited  for  use  at  the  Annual  Meeting  of
Stockholders  (the "Annual Meeting") to be held at 10:00 a.m. local time on June
18,  1997,  at  the  Park  Hyatt  Hotel,  333  Battery  Street,  San  Francisco,
California.  The  approximate  date  on  which  this  proxy  statement  and  the
accompanying notice and proxy are being mailed to stockholders is May 19, 1997.


VOTING

     Only stockholders of record at the close of business on April 23, 1997, are
entitled to notice of, and to vote at, the Annual  Meeting and any  adjournments
or postponements thereof. At the close of business on that date, the Company had
outstanding  18,418,492  shares of its Common Stock, $.01 par value (the "Common
Stock").  Holders of a majority of the outstanding shares of Common Stock of the
Company,  either present in person or by proxy, will constitute a quorum for the
transaction  of  business  at the Annual  Meeting.  Holders of Common  Stock are
entitled  to one vote for each share of Common  Stock held.  In the  election of
directors,  the eight (8) candidates receiving the highest number of affirmative
votes of the shares  present  and voting at the Annual  Meeting  will be elected
directors. An affirmative vote of a majority of the shares present and voting at
the meeting is generally  required for approval of any other items  submitted to
the stockholders for their  consideration.  Abstentions and broker non-votes are
each  included  in the  determination  of  whether  a quorum is  present  at the
meeting. Each is tabulated separately; abstentions are counted in tabulations of
the votes cast on proposals  presented to stockholders  and have the same effect
as negative  votes,  while  broker  non-votes  are not  counted for  purposes of
determining whether a proposal has been approved or not.

REVOCABILITY OF PROXIES

     Any  stockholder  giving a proxy has the power to revoke the proxy prior to
its exercise.  A proxy can be revoked by an  instrument of revocation  delivered
prior to the Annual Meeting to the Secretary of the Company,  by a duly executed
proxy  bearing a later  date or time  than the date or time of the  proxy  being
revoked,  or at the Annual  Meeting if the  stockholder is present and elects to
vote in person. Mere attendance at the Annual Meeting will not serve to revoke a
proxy.

SOLICITATION OF PROXIES

     Solicitation  of  proxies  may be made by  directors,  officers  and  other
employees of the Company by personal interview, telephone, telegraph or telefax.
No  additional  compensation  will  be paid  for any  such  services.  Costs  of
solicitation will be borne by the Company. APS will, upon request, reimburse the
reasonable  charges  and  expenses  of  brokerage  houses or other  nominees  or
fiduciaries  for  forwarding  proxy  materials  to, and  obtaining  authority to
execute proxies from,  beneficial  owners for whose accounts they hold shares of
Common Stock.

                                        1


<PAGE>


                     PROPOSAL ONE--ELECTION OF DIRECTORS

     Eight directors are to be elected to the Board at the Annual Meeting,  each
to serve for a one year term  until the Annual  Meeting to be held in 1998,  and
until his or her  successor  has been  elected and  qualified.  All the nominees
presently  are  directors of APS. It is intended  that proxies  received will be
voted "FOR" the election of the nominees,  unless  marked to the  contrary.  The
Board  has no  reason  to  believe  that any of the  nominees  will be unable or
unwilling  to serve as a director  if  elected.  If any  nominee  should  become
unavailable prior to the election,  the accompanying proxy will be voted for the
election of any nominee who is  designated  by the present Board of Directors to
fill the vacancy.

INFORMATION CONCERNING THE BOARD OF DIRECTORS:

     The  nominees for  Directors  of APS and their ages and  position  with the
Company are as follows:


                                                                 DIRECTOR
          NAME             AGE   POSITION WITH COMPANY            SINCE
- ----------------------    -----  ---------------------------    ----------
John J. Meakem, Jr.        60    Chairman, President and CEO       1991
Carl Ehmann, M.D.(3)       54    Director                          1994
Jorge Heller, Ph.D.(3)     69    Director                          1991
Peter Riepenhausen(2)      60    Director                          1991
Toby Rosenblatt(1)(2)      58    Director                          1983
Gregory H. Turnbull(1)     58    Director                          1986
C. Anthony Wainwright      63    Director                          1996
Dennis Winger(1)           49    Director                          1993

- -----------------
(1) Member of the Finance and Audit Committee of the Board.
(2) Member of the Compensation and Stock Option Committee of the Board.
(3) Member of the Science Oversight Committee of the Board.

     John J. Meakem,  Jr.--chief  executive  officer and  president of APS since
June, 1991,  director since July, 1991; chairman of APS board of directors since
March,  1993;  chairman of Premier,  Inc., a privately  held company,  from 1986
until  its  acquisition  by APS in 1993.  From  1970 to  1986,  Mr.  Meakem  was
corporate  executive  vice  president and president of Combe,  North America and
Combe,  Inc.  Prior to that Mr. Meakem was vice  president of  Richardson-Vicks,
Inc.

     Carl Ehmann, M.D.,  F.A.C.P.--director  of APS since June, 1994. Dr. Ehmann
currently  serves as a  director  of  Reckitt  & Colman  plc.  Formerly,  he was
executive  vice  president-research  and  development of R.J.  Reynolds  Tobacco
Company  where  he also  served  as a  member  of the  executive  and  operating
committee  from 1992 until 1996.  From 1987 until 1992,  he was  Executive  Vice
President of Research and  Development at Johnson & Johnson  Consumer  Products,
Inc.

     Jorge  Heller,  Ph.D.--director  of APS  since  April,  1991 and  executive
director of the APS Research  Institute  since  January,  1994.  Dr.  Heller was
director  of the  controlled  release  and  biomedical  polymers  program at SRI
International until January, 1994, where he was a staff member since 1974. He is
also  adjunct  professor  of  pharmacy  at the  University  of  California,  San
Francisco,  and at the  University  of Utah.  He is  editor  of the  Journal  of
Controlled Release and past president of the Controlled Release Society.

     Peter  Riepenhausen--director of APS since April, 1991. Mr. Riepenhausen is
currently  president  and chief  executive  officer of ReSound  Corporation.  He
serves as a director of Caradon  (Europe)  plc.  and Weru A.G. He served as vice
chairman of the board of directors of The Cooper  Companies,  Inc. from January,
1987 until September,  1989, and from January, 1984 until December,  1986 he was
executive vice president of The Cooper Companies, Inc. Mr. Riepenhausen has also
held  executive  positions  with  Blendax-Werke  R. Schneider GmbH & Co. of West
Germany and Pepsico, Inc.

     Toby  Rosenblatt--director of APS since September,  1983. Mr. Rosenblatt is
president of The Glen Ellen Company and Vice President of Founders  Investments,
Ltd. Both companies are involved in private

                                        2


<PAGE>

investment  activities.  Mr.  Rosenblatt  serves  as  a  director  of  Biosource
Technologies  Inc. and State Street  Research Mutual Funds. He is also a trustee
of numerous civic and educational institutions.

     Gregory H. Turnbull--director of APS since February,  1986. Mr. Turnbull is
currently a self- employed  consultant and a director of Planar Systems.  He was
managing  director of Kemper  Securities from mid-1992 to April,  1993. Prior to
that, he was a partner of Cable & Howse Ventures, a venture capital organization
which he first joined in 1983,  and of which he is  currently a special  limited
partner.


     Charles  Anthony  Wainwright--director  of APS since  November,  1996.  Mr.
Wainwright  is  currently  vice  chairman  of  McKinney  &  Silver,  a  national
advertising agency and a director of the following companies:  Gibson Greetings,
American Woodmark Corp., Del Webb Corp., Caribiner Corp., and All Comm Media. He
was the  chairman of Harris Drury Cohen from 1995 until early 1997 and from 1990
to 1995, he was the chairman of Compton Partners, Saatchi & Saatchi. He was also
the President and Chief Operating Officer of the Bloom Companies from 1980 until
1989.

     Dennis  Winger--director  of  APS  since  February,  1993.  Mr.  Winger  is
currently senior vice president,  finance and administration and chief financial
officer  of  Chiron  Corporation.  He is  also a  member  of  Chiron's  Strategy
Committee.  Prior to  joining  Chiron,  Mr.  Winger  held a series of  financial
positions at The Cooper Companies, Inc., including chief financial officer.

MEETINGS AND COMMITTEES OF THE BOARD

     The Board of  Directors  met 8 times  during  1996.  Each of the  directors
participated in at least 75% of the total number of meetings of the Board and of
the committees of the Board on which each served.

     The Board  has a Finance  and Audit  Committee,  a  Compensation  and Stock
Option  Committee  and a Science  Oversight  Committee.  The  Finance  and Audit
committee,  which met 5 times during the last fiscal year,  consisted of Messrs.
Rosenblatt,  Turnbull  and Winger.  The Finance and Audit  Committee  recommends
engagement  of the  Company's  independent  auditors  and  reviews the scope and
results of the annual independent audit of the Company's books and records.  The
Committee  is also  responsible  for  reviewing  and  evaluating  the  Company's
accounting  principles  and its  system of  internal  accounting  controls,  and
reviewing its plans for providing appropriate financial resources to sustain the
Company's operations.  The Compensation and Stock Option Committee,  which met 3
times during the year,  consisted of Messrs.  Rosenblatt and  Riepenhausen.  The
function of the Compensation and Stock Option Committee is to propose and review
the compensation  policies of the Company and to administer the Company' s stock
option plan. The Science Oversight Committee, which met 5 times during the year,
consisted of Dr. Ehmann and Dr.  Heller.  The function of the Science  Oversight
Committee is to review the Company's research and development activities.

COMPENSATION OF DIRECTORS

     Under the Company's 1992 Stock Option Plan,  each  nonemployee  director of
the  Company is  automatically  granted an option to  acquire  10,000  shares of
Common Stock annually and receives a one-time  automatic grant to acquire 25,000
shares when first  elected as a director.  The Company paid no other  Directors'
fees for the fiscal year ended  December  31,  1996.  Certain  directors  of the
Company have received consulting fees. See "Certain Transactions."

                                        3


<PAGE>

                 COMMON STOCK OWNERSHIP OF CERTAIN BENEFICIAL
                            OWNERS AND MANAGEMENT

     The  following  table sets forth  beneficial  Common Stock  ownership as of
April  23,  1997,  (i) by  each  person  who is  known  by  the  Company  to own
beneficially  more than 5% of the  outstanding  shares of Common Stock,  (ii) by
each  director,  including  nominees,  and each  executive  officer named in the
Summary  Compensation  Table  included in the Proxy  Statement  and (iii) by all
executive officers and directors as a group. Each person has sole investment and
voting power with respect to the shares indicated, subject to community property
laws where  applicable and except as otherwise set forth in the footnotes to the
table.


                                                  NUMBER OF   PERCENT OF
                      NAME                        SHARES(1)    CLASS(1)
- ----------------------------------------------- ----------- ------------
Robert Albus(2) ..............................    388,939         2.1
Carl Ehmann, M.D., F.A.C.P.(3) ...............     50,750         *
Jorge Heller, Ph.D.(4) .......................     80,000         *
John J. Meakem, Jr.(5) .......................    729,043         3.9
Sergio Nacht(6) ..............................    143,705         *
Michael O'Connell(7) .........................    226,837         1.2
Peter Riepenhausen(8) ........................     78,000         *
Les Riley(9) .................................     39,662         *
Toby Rosenblatt(10) ..........................    245,526         1.3
Gregory H. Turnbull(11) ......................     55,000         *
C. Anthony Wainwright(12) ....................      1,000         *
Dennis Winger(13) ............................     55,000         *
Johnson & Johnson Development Corporation  ...  2,155,107        11.7
 One Johnson & Johnson Plaza
 New Brunswick, NJ 08933
Smith Barney Holdings, Inc. ..................  2,871,844        15.6
 388 Greenwich Street
 New York, NY 10013
Officers and Directors as a group (12 persons)  2,093,462        10.5
 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)

- ---------------
   *  Less than one percent.

 (1)  Assumes the exercise of all  outstanding  options and warrants to purchase
      Common Stock held by such person or group to the extent  exercisable on or
      before  June  23,  1997,  and  that no  other  person  has  exercised  any
      outstanding stock options.
 (2)  Includes 187,500 shares underlying presently exercisable stock options.
 (3)  Includes 48,750 shares underlying presently exercisable stock options. 
 (4)  Consists of 80,000 shares underlying presently exercisable stock options.
 (5)  Includes 507,081 shares underlying presently exercisable stock options.
 (6)  Includes 122,500 shares underlying presently exercisable stock options.
 (7)  Includes 226,249 shares underlying presently exercisable stock options.
 (8)  Includes 3,000 shares held as joint tenant with Mr.  Riepenhausen's spouse
      and 75,000 shares underlying presently exercisable stock options.
 (9)  Includes 39,584 shares underlying presently exercisable stock options.
(10)  Includes 55,000 shares underlying presently exercisable stock options.
(11)  Consists of 55,000 shares underlying presently exercisable stock options.
(12)  Mr.  Wainwright  currently has no  exercisable  options,  but holds 25,000
      stock  options  which  will vest over four years from the date on which he
      became a director of the Company.
(13)  Consists of 55,000 shares underlying presently exercisable stock options.


                                        4
<PAGE>

COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT

     Section 16(a) of the Securities Exchange Act of 1934 requires the Company's
officers and directors, as well as any holders of more than 10% of the Company's
Common  Stock,  to file with the  Securities  and  Exchange  Commission  certain
reports of  ownership  and reports of changes in  ownership  of Common Stock and
other equity  securities of the Company.  Based solely on review of such reports
and certain  representations  furnished to it, the Company  believes that during
the fiscal year ended December 31, 1996, except for John J. Meakem,  Jr. who was
delayed in filing a Form 5 reporting a certain  stock option grant and Les Riley
who was delayed in filing his initial report on Form 3, all Section 16(a) filing
requirements applicable to its officers and directors were complied with.


                             EXECUTIVE COMPENSATION
<TABLE>
     The following Summary  Compensation  Table shows the total compensation for
fiscal years 1996, 1995 and 1994 of the chief executive  officer and each of the
other four most highly  compensated  executive  officers  whose salary  exceeded
$100,000 in 1996.

SUMMARY COMPENSATION TABLE

<CAPTION>
                                                                  LONG-TERM
                                                                 COMPENSATION
                                                   ANNUAL       --------------
                                                COMPENSATION        AWARDS
                                              --------------    --------------
                                              SALARY    BONUS      OPTIONS       ALL OTHER
          NAME AND POSITION            YEAR     ($)      ($)         (#)       COMPENSATION(1)
          -----------------            ----   ------    -----        ---       --------------
<S>                                   <C>    <C>       <C>      <C>                <C>
John J. Meakem, Jr.                   1996   324,693        0         0            4,500
 Chairman, President and              1995   310,962        0   150,000            4,500
 Chief Executive Officer              1994   290,122        0    50,000            1,000

Robert Albus                          1996   200,000        0         0            3,000
 Senior Vice President,               1995   200,000        0    25,000            3,082
 President of Premier                 1994   194,790        0         0            1,000

Sergio Nacht, Ph.D.                   1996   172,000        0    10,000            4,480
 Senior Vice President                1995   170,115        0    20,000            4,433
                                      1994   167,727        0    20,000            1,000

Michael O'Connell                     1996   195,962   10,000    40,000            4,500
 Executive Vice President, Chief      1995   182,308        0    30,000            4,500
 Financial and Administrative Officer 1994   172,779        0   100,000            1,000

Les Riley(2)                          1996   190,769   10,000   125,000            3,249
 Senior Vice President                1995         0        0         0                0
                                      1994         0        0         0                0
<FN>
- ------------
(1)   The stated  amounts are Company  matching  contributions  to the  Advanced
      Polymer Systems Salary Reduction Profit Sharing Plan. In 1996, the Company
      made   matching   contributions   equal  to  50%  of  each   participant's
      contribution  during  the plan  year up to a maximum  amount  equal to the
      lesser of 3% of each participant's annual compensation or $4,500.

(2)   Mr. Riley joined the Company in January, 1996 and he was compensated at an
      annual rate of $200,000.
</FN>
</TABLE>

                                        5
<PAGE>


<TABLE>
   The following  table sets forth certain  information  with respect to options
granted during 1996 to the executive officers named in the Summary  Compensation
Table.

STOCK OPTION GRANTS IN 1996

<CAPTION> 
                                                                                    POTENTIAL
                                                                                    REALIZABLE
                                                                                  VALUE AT ASSUMED
                                                                                  ANNUAL RATES OF
                                                                                       STOCK
                                                                                 PRICE APPRECIATION
                                                                                       FOR
                                           INDIVIDUAL GRANTS                      OPTION TERM(1)
                          ---------------------------------------------------    -------------------
                            NUMBER OF
                            SECURITIES    % OF TOTAL
                            UNDERLYING     OPTIONS
                             OPTIONS      GRANTED TO    EXERCISE
                             GRANTED     EMPLOYEES IN    PRICE     EXPIRATION
           NAME               (#)(2)     FISCAL YEAR     ($/SH)       DATE        5% ($)    10% ($)
- ------------------------ ------------   -------------  ----------  ----------    --------  --------
<S>                          <C>            <C>         <C>        <C>          <C>       <C>    
John J. Meakem, Jr. .....          0         0.0           N/A          N/A           0         0
Robert Albus ............          0         0.0           N/A          N/A           0         0
Sergio Nacht, Ph.D. .....     10,000         2.3        $8.125     09/24/06      51,098   129,492
Michael P.J. O'connell ..     40,000         9.2        $6.250     07/24/06     157,224   398,436
Les Riley ...............    100,000        23.1        $6.250     01/10/06     393,059   996,089
Les Riley ...............     25,000         5.8        $8.125     09/24/06     127,744   323,729

<FN>
- ------------
(1)   Potential realizable value is based on an assumption that the price of the
      Common Stock  appreciates at the annual rate shown  (compounded  annually)
      from the date of grant  until  the end of the ten year  option  term.  The
      numbers  are  calculated  based  on the  requirements  promulgated  by the
      Securities  and  Exchange  Commission  ("SEC")  and  do  not  reflect  the
      Company's  estimate of future stock price growth.  

(2)   The options  granted under the Company's  1992 Stock Plan  typically  vest
      over 4 years at 25%  annually.  Payments on exercise,  including any taxes
      the  Company  is  required  to  withhold,  may be made in cash,  by a full
      recourse  promissory  note or by tender of shares.  Options are granted at
      fair market value on the date of grant.
</FN>
</TABLE>

<TABLE>
     The following table sets forth certain  information with respect to options
exercised  during  1996 and the value of options  held at fiscal year end by the
executive officers named in the Summary Compensation Table.

AGGREGATED OPTION EXERCISES IN 1996 AND 1996 YEAR-END OPTION VALUES

<CAPTION>
                                                                                     VALUE OF UNEXERCISED
                                                       NUMBER OF UNEXERCISED         IN-THE-MONEY OPTIONS
                                                     OPTIONS AT 1996 YEAR-END        AT FISCAL YEAR-END(2)
                       SHARES ACQUIRED            ----------------------------- -----------------------------
                         UPON OPTION      VALUE     EXERCISABLE   UNEXERCISABLE   EXERCISABLE   UNEXERCISABLE
          NAME             EXERCISE    REALIZED(1)       (#)            (#)            ($)            ($)
- ---------------------- --------------- ---------- ------------- --------------- ------------- ---------------
<S>                        <C>           <C>          <C>           <C>             <C>           <C>
John J. Meakem, Jr. ....   30,000        107,734      457,081       170,833         886,085       399,478
Robert Albus ...........        0              0      184,375        15,625         306,328        37,109
Sergio Nacht, Ph.D. ....   85,000        260,250      115,230        29,770         186,688        47,375
Michael P.J. O'Connell..        0              0      192,917       107,083         221,249       244,061
Les Riley ..............        0              0        1,563       123,437               0       137,500
<FN>
- ---------------
(1)  Market value of underlying securities at exercise less the exercise  price.
(2)  Market value of underlying securities at fiscal year end minus the exercise
     price of "in-the-money" options.
</FN>
</TABLE>

     APS did not make any awards  during 1996 to any of the  executive  officers
named in the Summary  Compensation  Table  under any  long-term  incentive  plan
providing  compensation  intended to serve as an incentive  for  performance  to
occur over a period longer than one fiscal year, excluding options.

                                        6


<PAGE>



              REPORT OF THE COMPENSATION AND STOCK OPTION COMMITTEE

     The  Compensation and Stock Option Committee of the Board of Directors (the
"Committee") is responsible for establishing compensation policies applicable to
the Company's executive officers and, pursuant to such policies, determining the
compensation  payable  to  the  Company's  chief  executive  officer  and  other
executive officers of the Company.  The committee consists of Peter Riepenhausen
and Toby Rosenblatt, each of whom is a non-employee director of the Company. The
following  report  relates to  compensation  payable to the Company's  executive
officers for the year ended December 31, 1996.

COMPONENTS OF COMPENSATION

     There are three (3)  components  of  compensation  payable to the Company's
executive officers; base salary, equity-based incentive compensation in the form
of stock options and annual incentive  compensation in the form of cash bonuses,
although no incentive bonuses were paid in 1996.

COMPENSATION POLICIES

     The Company's compensation policies for all employees,  including executive
officers,  are  designed  to  provide  targeted  compensation  levels  that  are
competitive  with those of regional high  technology  companies of similar size,
with whom the company must compete in the recruitment of senior  personnel.  The
Committee  also wished to tie  incentive  cash bonuses to the  achievement  of a
pre-established plan and to use stock options to promote equity-ownership in the
Company at levels deemed  appropriate  by the Committee for executive  officers.
The  goals  of the  Committee  are to  align  compensation  with  the  Company's
objectives  and  performance,  and to enable the Company to attract,  retain and
reward  executives who contribute to the long-term  success of the Company.  The
Company does not believe that compensation  payable by it will be subject to the
limitations  on  deductibility  provided  under  Section  162(m) of the Internal
Revenue Code.

     The Committee  retained the services of a compensation  consulting  firm to
provide data regarding  competitive levels of salary compensation and to provide
general guidance to the Committee in evaluating executive compensation.

BASE SALARIES

     The salary component of executive  compensation is based on the executive's
level of  responsibility  for meeting the Company's  objectives and performance,
and  comparison to similar  positions in the Company and  comparable  companies.
Base salaries for executive officers are reviewed and adjusted annually based on
information  regarding  competitive  salaries,   including  salary  survey  data
provided  by  third  parties  regarding  regional  high  technology   companies.
Individual  increases  are  established  by the  Committee  (taking into account
recommendations   of  the  chief  executive   officer   concerning  the  overall
effectiveness of each executive.)

CASH BONUSES

     Incentive cash bonuses are determined based on the Company's achievement of
certain pre-established  performance objectives.  No incentive bonuses were paid
in 1996.

STOCK OPTIONS

     The  Company's  compensation  policies  recognize  the  importance of stock
ownership by senior  executives  and stock  options are an integral part of each
executive's compensation.  The Committee believes that the opportunity for stock
appreciation   through   stock   options  which  vest  over  time  promotes  the
relationship between long-term interests of executive officers and stockholders.
The size of specific grants takes into account the executive  officer's  salary,
number of options  previously  granted,  as well as shares of Common Stock held,
and the contributions to the Company's success.

                                        7


<PAGE>


COMPENSATION PAYABLE TO CHIEF EXECUTIVE OFFICER

     The 1996 salary for Mr. Meakem, the Company's chairman, president and chief
executive officer,  was determined  principally from the terms of his employment
agreement  with the Company dated May 1, 1993.  The  Compensation  Committee and
Board of Directors  increased the base salary of $315,000 to $330,000  effective
May 1, 1996. This increase in base salary  corresponds to the average percentage
increase in salaries payable to all employees.  As of April 23, 1996, Mr. Meakem
holds presently  exercisable  options to purchase 498,748 shares and,  including
options,  beneficially  owns as of that date  720,710  shares  of the  Company's
Common Stock.  

                              Compensation and Stock Option Committee 


                              Peter Riepenhausen  
                              Toby Rosenblatt




                                        8


<PAGE>


                                PERFORMANCE GRAPH

     The rules of the SEC require APS to include in this Proxy  Statement a line
graph  presentation  comparing  cumulative five year stockholder  returns,  on a
dividend  reinvested  basis,  with  broad  based  equity  index and a  published
industry  index.  The  Company  has  selected  the S&P 500  Stock  Index and H&Q
Technology  Stock Index for purposes of the comparison  which appears below. The
graph assumes that $100 was invested in APS stock and each index on December 31,
1991, with all dividends  reinvested.  Past stock performance is not necessarily
indicative of future results.


[The following  descriptive  data is supplied in accordance  with Rule 304(d) of
Regulation S-T]


<TABLE>
<CAPTION>
                               12/91   12/92   12/93   12/94   12/95   12/96   2/97
                             ------- ------- ------- ------- ------- ------- ------
<S>                            <C>     <C>     <C>     <C>     <C>     <C>     <C>
ADVANCED POLYMER SYS INC. ...  100      80      50      42      52      73      77
S&P 500 .....................  100     108     118     120     165     203     217
H&Q TECHNOLOGY ..............  100     115     126     146     219     262     268
</TABLE>

                              CERTAIN TRANSACTIONS

     The Company entered into a three-year  employment agreement with Mr. Meakem
in May 1993. In 1995,  the  employment  agreement was amended to extend the term
for an  additional  three  years and  provide for  automatic  yearly  extensions
thereafter  unless written notice of its intention not to  automatically  extend
the agreement is given by either party. The employment  agreement  provides that
Mr. Meakem may elect to terminate  his  employment  within  stated  periods of a
change in control of the Company (defined to include an acquisition of more than
fifty  percent of the  outstanding  shares of the Company) and receive an amount
equal to his prior twelve months' salary and bonus,  payable over the subsequent
twelve month period.  Mr. Meakem is entitled to receive an amount equal to twice
his prior twelve months'  salary and bonus if the Company  should  terminate his
employment  within  stated  periods  of a change in  control  or if he elects to
terminate his employment  following a change in control if his position with the
Company is reduced in terms of responsibility or indicia of status.

     During  1996,   the  Company  paid  to  Dr.  Jorge  Heller  and  Mr.  Peter
Riepenhausen,  both of whom are directors of the Company for consulting services
in their  fields of  expertise,  the  respective  amounts  of  $127,330  and $0.
Payments for similar services in 1995 were $48,000 and $0, respectively,  and in
1994 were $48,000 and $47,000, respectively.

                                        9


<PAGE>



     The Company has entered into agreements with Biosource  Technologies,  Inc.
("Biosource")  of which Toby  Rosenblatt  is a director and a  stockholder.  All
agreements  between  APS and  Biosource  have  been,  and will  continue  to be,
considered and approved by a vote of the disinterested directors. The agreements
provide  APS with  worldwide  rights  to use and sell  Biosource's  biologically
synthesized  melanin in Microsponge  systems for all sun  protection,  cosmetic,
ethical dermatology and over-the-counter  skin care purposes.  In return, APS is
required to make annual  minimum  purchases of melanin,  and to pay royalties on
sales  of  melanin-Microsponge   products  including  certain  prepayments.  For
estimated  losses on purchase  commitments  and related  inventory,  the Company
accrued  $1,400,000,  $600,000 and $685,000 in 1996, 1995 and 1994 respectively.
During 1994, the Company paid Biosource $263,403 for the supply of melanin.  All
minimum financial commitments under the current agreements have been expensed by
APS.

     In 1996, APS paid Biosource the 1995 minimum purchase commitment by issuing
94,000 shares of APS common stock.

                     PROPOSAL TWO--APPROVAL OF THE AMENDMENT
                        TO THE COMPANY'S 1992 STOCK PLAN

     Section  162(m) of the  Internal  Revenue  Code of 1986,  as  amended  (the
"Code"), enacted in August 1993, limits the deductibility by public companies of
compensation in excess of $1 million per year (subject to some  exemptions) paid
to certain executive  officers  (generally,  the Chief Executive Officer and the
other four most highly compensated executive officers).  As the limit applies in
the year in which the  compensation  is paid,  it could apply to income  derived
from the exercise of certain stock  options,  measured by the spread between the
exercise  price and the fair market  value at the time the option is  exercised.
Options  granted  prior to February  17,  1993 are not subject to the  deduction
limitation under this law.

     "Performance  based"  compensation  is excluded from  compensation  counted
toward  the  $1  million   deduction  limit  if  certain   conditions  are  met.
Compensation  resulting  from the  exercise of stock  options will be treated as
"performance  based" and excluded from the limit on deductibility if among other
things,  the plan under which the options  are granted  specifies  limits on the
number of shares  issuable to any participant in any one year under the plan and
these limits are approved by the issuer's stockholders.

     In order  to  exclude  from the $1  million  deduction  limit  compensation
resulting  from the exercise of options  granted under the Company's  1992 Stock
Plan  (the  "1992  Stock  Plan"),  the Board of  Directors  adopted  subject  to
stockholder  approval an amendment to limit the number of shares with respect to
which  options may be granted  under the 1992 Stock Plan to no more than 250,000
shares to any one participant in any one-year period.

DESCRIPTION OF THE 1992 PLAN

     The following is a general summary of the principal  provisions of the 1992
Stock Plan.  The 1992 Plan  authorizes  the granting of Incentive  Stock Options
("ISOs") to employees  (including  employees who are officers and directors) and
Nonstatutory Options ("NSOs") to officers, directors,  employees and consultants
to purchase  authorized,  but unissued shares of the Company's Common Stock. The
number of shares  reserved for issuance on the exercise of options granted under
the 1992 Plan is 3,250,000.  The 1992 Plan is administered by a committee of the
Board (the  "Administrator")  who determines the terms of options  granted under
the 1992 Plan,  including the exercise  price,  number of shares  subject to the
option,  whether the option is an ISO or an NSO,  and the  schedule  pursuant to
which the option shall become  exercisable.  No option may be granted  under the
1992 Plan after March,  2002,  but  outstanding  options may extend  beyond that
date.

     The 1992 Plan provides for automatic option grants to nonemployee directors
of the Company.  The Company does not pay any  directors  fees for services as a
director,  and  uses  NSOs  as an  alternative  way  to  compensate  nonemployee
directors and to provide  incentives  to them through an equity  interest in the
Company.  Under the 1992 Plan,  a 10 year NSO to purchase  25,000  shares of the
Company's  Common Stock will be granted to each person who is neither an officer
nor an employee of the Company  when such person is first  elected or  appointed
director.  Each such  option  vests at the rate of 25% per year,  so long as the
individual is serving as a director, with full vesting over four years. The 1992
Plan also provides for the grant of a ten year NSO to purchase  10,000 shares of
Common Stock on the date of each annual

                                       10


<PAGE>


meeting  of  stockholders  of the  Company  held  more  than 12  months  after a
nonemployee  director is first  elected or appointed to the Board of  Directors.
These options fully vest one year after the date of grant.

     The exercise  price of each option  granted  under the 1992 Plan must be at
least equal to 100% of the fair market value of the underlying  shares of Common
Stock on the date of grant.  The 1992 Plan  provides that the maximum term of an
option  is  ten  years.  With  respect  to any  participant  then  owning  stock
possessing  more than ten  percent  (10%) of the voting  power of the  Company's
outstanding  capital stock,  the exercise price of any ISO must be at least 110%
of fair market  value of the  underlying  shares of Common  Stock on the date of
grant,  and the term may be no longer than five years. The 1992 Plan permits the
exercise  of  options  for  cash,   a  check,   or  with  the  approval  of  the
Administrator,  tender to the Company of shares of the  Company's  Common  Stock
owned by the  optionee  and having a fair market  value not less than the option
exercise price or delivery of full recourse promissory notes.

     The 1992 Plan limits to $100,000 the value of option stock (measured at the
time of the option grant) with respect to which ISOs granted to any one employee
after 1986 under any Company plan may vest in any calendar year.

     At the time an option  is  exercised,  in whole or in part,  or at any time
thereafter  as  requested  by the  Company,  the  optionee  is  required to make
adequate  provision for federal and state income and employment tax  withholding
obligations  of the Company,  if any,  resulting  from the exercise.  Subject to
certain  limitations,  an optionee  may elect,  subject to the terms of the 1992
Plan and the  approval  of the  Administrator,  to have  shares of Common  Stock
issuable on exercise of the options  withheld or to tender  shares then owned by
the optionee to provide for these taxes.

     Generally,  options  are  exercisable  not upon  grant,  but in  cumulative
increments  over time,  typically  25% per year over four years.  Options may be
exercised  for thirty days after the  optionee  leaves the  Company  and, if the
optionee's  employment is terminated by reason of death or permanent disability,
for one year after the optionee's  death or  disability,  but in either case not
beyond the original term of the option.

     In the event of a merger of the Company,  sale of substantially  all of its
assets or similar  transaction,  the  Administrator  may,  among  other  things,
accelerate the expiration date and the exercisability of all options outstanding
under the 1992 Plan.

     Under the 1992 Plan,  the  Administrator  also may grant to  participants a
direct  right  to  purchase  shares  by  notifying  the  grantee  of the  terms,
conditions and restrictions relating to the purchase right.

     The 1992 Plan  expires in March,  2002,  unless  terminated  earlier by the
Board of Directors.  The Board may at any time terminate or amend the 1992 Plan,
provided that without approval of stockholders  there will be no increase in the
total number of shares  covered by the 1992 Plan.  In any case, no amendment may
adversely  affect any  then-outstanding  option or unexercised  portion  thereof
without the  optionee's  consent unless such amendment is required to enable the
option to qualify as an ISO.

FEDERAL INCOME TAX CONSEQUENCES OF STOCK OPTIONS

     The following  description of federal income tax consequences is based upon
current  statutes,   regulations  and  interpretations   thereof.   Because  the
applicable  rules are  complex  and  because  income tax  consequences  may vary
depending upon the individual  circumstances of each optionee,  optionees should
consult their personal tax advisors concerning federal, state, local and foreign
income tax consequences associated with their participation in the 1992 Plan.

     ISOs  granted  under the 1992 Plan are  intended to  constitute  "incentive
stock  options"  within the meaning of the Section 422 of the Code.  ISOs may be
granted  only to  employees  of the Company  (including  directors  who are also
employees).  An optionee does not recognize taxable income upon either the grant
or  exercise  of an ISO.  However,  the excess of the fair  market  value of the
shares  purchased  upon  exercise  over the option  exercise  price (the "Option
Spread")  is  includible  in the  optionee's  "alternative  minimum  tax income"
("AMTI"),  used to calculate the "alternative minimum tax". The Option Spread is
measured on the date of exercise and is generally includible in AMTI in the year
of exercise.

                                       11


<PAGE>


     If an  optionee  holds the  shares for at least two years from the date the
ISO was granted,  and for at least one year from the date the ISO was exercised,
any long-term  gain from a sale of the shares should be taxable as capital gain.
Under these circumstances,  the Company would not be entitled to a tax deduction
at the  time the ISO is  exercised  or at the  time  the  stock  is sold.  If an
optionee were to dispose of stock acquired  pursuant to an ISO before the end of
the required  holding  periods (a  "Disqualifying  Disposition"),  the amount by
which the market  value of the stock at the time the ISO was  exercised  exceeds
the exercise  price (or, if less, the amount of gain realized on the sale) would
be  taxable  as  ordinary  income,  and the  Company  should  be  entitled  to a
corresponding tax deduction. A gain in a Disqualifying Disposition, in excess of
the amount  required to be recognized  as ordinary  income,  if any,  would be a
capital gain.

     If an optionee pays for option  shares with shares of the Company  acquired
under an ISO or other  qualified  stock option  ("statutory  option  stock") the
tender of shares is a Disqualifying Disposition of the statutory option stock if
the applicable  holding periods respecting those shares have not been satisfied.
If the holding periods with respect to the statutory option stock are satisfied,
or the shares were not acquired under an ISO or other  qualified stock option of
the Company,  then any  appreciation in value of the  surrendered  shares is not
taxed upon surrender.

     An optionee is not taxed upon the grant of an NSO. Generally,  the optionee
will recognize as ordinary income the Option Spread on the date of exercise. The
Company  is  entitled  to a  deduction  equal to the amount of  ordinary  income
recognized by an optionee.  Such income is subject to income tax  withholding by
the Company.

     If shares of Common Stock are delivered in payment of the exercise price of
an NSO, the  appreciation in value of the surrendered  shares is not then taxed.
The use of shares  previously  acquired by exercise of an ISO or other statutory
stock option may be a  Disqualifying  Disposition of those shares,  although the
IRS has announced that it is studying this point.  It is possible,  although the
Company  believes it  unlikely,  that  election by an optionee to have shares of
Common  Stock  withheld  in  satisfaction  of  the  optionee's  withholding  tax
obligations upon exercise of an NSO or  Disqualifying  Disposition of ISO shares
may result in dividend income to the optionee.

                                       12


<PAGE>



     The  following  table  shows the  number of  options  granted  to the named
individuals and groups under the 1992 Stock Plan during 1996.


                                PLAN BENEFITS
                               1992 STOCK PLAN

               NAME AND POSITION                   NUMBER OF OPTIONS(1)
               -----------------                   --------------------

John J. Meakem, Jr. ...........................            0
Chairman, President and Chief Executive Officer

Robert Albus ..................................            0
Senior Vice President, President of Premier

Sergio Nacht, Ph.D. ...........................       10,000
Senior Vice President

Michael O'Connell .............................       40,000
Executive Vice President, Chief Financial and
  Administrative Officer

Les Riley .....................................      125,000
Senior Vice President

Executive Officers as a Group .................      175,000
Non-Executive Director Group ..................       95,000
Non-Executive Officer Employee Group  .........      215,500

- ------------
(1)  All options granted at fair market value on the date of the grant.


PROPOSAL

     At the Annual Meeting,  stockholders  will be asked to approve an amendment
to the  Company's  1992 Stock Plan to limit the number of shares with respect to
which  options  may be  granted  to no  more  than  250,000  shares  to any  one
participant in any one-year  period.  Such approval will require the affirmative
vote of a majority of shares present and voting at the Annual Meeting. Copies of
the 1992 Plan are  available by writing to the Company to the attention of Marea
Fabrique, Investor Relations. The Board of Directors recommends a vote "FOR" the
proposal.

          PROPOSAL THREE--APPROVAL OF 1997 EMPLOYEE STOCK PURCHASE PLAN

     The Board of Directors has approved,  subject to stockholder approval,  the
1997 Employee Stock Purchase Plan ("Purchase  Plan").  The Purchase Plan permits
the Company's  employees to purchase the Company's  Common Stock at a discounted
price.  This plan is designed to encourage  and assist  employees of the Company
and  participating  subsidiaries  to acquire an equity  interest  in the Company
through  the  purchase  of shares of  Company  Common  Stock.  Approximately  77
employees of the Company are eligible to participate in the Purchase Plan.

     The Board of Directors has adopted,  subject to stockholder  approval,  the
Purchase  Plan  covering  400,000  shares  issuable  under the plan.  Management
expects these shares to be sufficient for all stock purchases under the plan for
approximately three years. As of April 23, 1997, no shares had been issued under
the Purchase Plan.

DESCRIPTION OF THE 1997 PLAN


     All employees, including executive officers, customarily employed more than
20 hours  per week  and more  than  five  months  per year by the  Company  or a
participating  subsidiary are eligible to participate in the Purchase Plan as of
the first semi-annual enrollment date following employment.  However,  employees
who hold, directly or through options,  five percent or more of the stock of the
Company  are  not  eligible  to  participate.  Participants  may  elect  to make
contributions up to a maximum of 10% of base

                                       13


<PAGE>



earnings.  Assuming  stockholder  approval of the Purchase  Plan, on October 31,
1997 and  thereafter on the last trading date of April and October,  the Company
applies the funds then in each participant's  account to the purchase of shares.
The cost of each share  purchased is 85% of the lower of the closing  prices for
Common Stock on: (i) the first trading day in the enrollment period in which the
purchase  is made;  and (ii) the  purchase  date.  The length of the  enrollment
period may not exceed a maximum  of 24  months.  Enrollment  dates are the first
business day of May and November  provided  that the first  enrollment  date was
April 30,  1997.  The Board may limit the  maximum  number of shares that may be
purchased by a participant  during any enrollment  period,  and no participant's
right to acquire  shares may accrue at a rate  exceeding  $25,000 of fair market
value of Common Stock  (determined  as the lower of the fair market value on the
first  trading  day in an  enrollment  period  or the fair  market  value on the
purchase date) in any calendar year.

     The Board of Directors  may  administer  the Purchase Plan or the Board may
delegate its  authority to a committee of the Board . The Board of Directors may
amend  or  terminate  the  Purchase  Plan at any  time  and may  provide  for an
adjustment in the purchase price and the number and kind of securities available
under the plan in the event of a reorganization,  recapitalization, stock split,
or other similar event.  However,  amendments  that would increase the number of
shares reserved for purchase, or would otherwise require stockholder approval in
order to comply with certain  federal tax laws,  require  stockholder  approval.
Shares available under the plan may be either  outstanding shares repurchased by
the Company or newly issued shares.

FEDERAL INCOME TAX CONSEQUENCES

     In general,  participants  will not have  taxable  income or loss under the
Purchase Plan until they sell or otherwise  dispose of shares acquired under the
plan (or die holding  such  shares).  If the shares are held,  as of the date of
sale or disposition,  for longer than both: (i) two years after the beginning of
the enrollment period during which the shares were purchased;  and (ii) one year
following purchase, a participant will have taxable ordinary income equal to 15%
of the fair market value of the shares on the first day of either the enrollment
period on purchase  date,  whichever  is lower (but not in excess of the gain on
the sale). Any additional gain from the sale will be long-term capital gain. The
Company is not entitled to an income tax  deduction  if the holding  periods are
satisfied.

     If the  shares  are  disposed  of  before  the  expiration  of  both of the
foregoing  holding periods (a "disqualifying  disposition"),  a participant will
have taxable ordinary income equal to the excess of the fair market value of the
shares  on  the  purchase  date  over  the  purchase  price.  In  addition,  the
participant  will  have  a  taxable  capital  gain  (or  loss)  measured  by the
difference between the sale price and the participant's  purchase price plus the
amount of ordinary income recognized,  which gain (or loss) will be long-term if
the  shares  have been  held as of the date of sale for more than one year.  The
Company is entitled to an income tax  deduction  equal to the amount of ordinary
income recognized by a participant in a disqualifying disposition.

                                       14



<PAGE>

     The  following  table  shows  the  "Dollar  Value"  and  number  of  shares
applicable to the named  individuals  and groups under the 1997  Employee  Stock
Purchase Plan during the year ended December 31, 1997, assuming contributions at
the  maximum  10% of base  earnings  and that  shares of  Common  Stock had been
purchased on the April and October 1997  purchase  dates under the Purchase Plan
at a purchase  price of $6.64,  an amount  which  represents  85% of the closing
price on the first trading date of the first enrollment  period which is assumed
for  purposes of this table to be in November  1996.  The "Dollar  Value" is the
difference  between  the fair  market  value of the Common  Stock on the assumed
first enrollment date of November 1, 1996 and the participant's assumed purchase
price of $6.64 per  share.  The  Purchase  Plan  provides  that no shares may be
purchased  until the plan has been approved by the  stockholders of the Company,
and that the first  purchase will be the first purchase date after such approval
is  obtained.  As a  consequence,  the  information  which  follows  is merely a
presentation of the "Dollar Value" and the number of shares  attributable to the
named  individuals and groups in 1997 based on the assumptions  indicated above,
and does not represent actual purchases.

                               PLAN BENEFITS 1997
                          EMPLOYEE STOCK PURCHASE PLAN

                                                 DOLLAR     NUMBER
               NAME AND POSITION                VALUE ($)  OF SHARES
- ---------------------------------------------- --------- -----------

John J. Meakem, Jr.(1) ........................      $    --      --
Chairman, President and Chief Executive
 Officer

Robert Albus ..................................        3,000    3,012
Senior Vice President and President of Premier

Sergio Nacht ..................................        2,550    2,560
Senior Vice President

Michael O'Connell .............................        2,939    2,951
Executive Vice President, Chief Financial and
 Administrative Officer

Les Riley .....................................        2,862    2,873
Senior Vice President

Executive Officers as a Group .................       11,351   11,396
Non-Executive Director Group (2) ..............          --       --
Non-Executive Officer Employee Group  .........       43,970   44,147

- ------------
(1)  Mr. Meakem is ineligible  to  participate  in this plan since he holds five
     percent or more of the stock of the  Company  directly  and  through  stock
     options outstanding.

(2)  Members of the Board of  Directors are  ineligible to  participate  in this
     plan, unless they are also an employee of the Company.

PROPOSAL


     At the Annual Meeting, the Company's  stockholders will be asked to approve
the  1997  Employee  Stock  Purchase  Plan.   Such  approval  will  require  the
affirmative  vote of a majority  of the shares  present and voting at the Annual
Meeting.  Copies of the 1997  Employee  Stock  Purchase  Plan are  available  by
writing to the Company to the attention of Marea Fabrique,  Investor  Relations.
The Board of Directors recommends a vote "FOR" the proposal.


                         INDEPENDENT PUBLIC ACCOUNTANTS

     The  Board  has  selected  KPMG  Peat  Marwick  LLP as  independent  public
accountants to audit the financial statements of the Company for the fiscal year
ending  December  31,  1997.  KPMG Peat  Marwick LLP has acted as the  Company's
auditors since the Company's  inception in 1983. A  representative  of KPMG Peat
Marwick LLP will be present at the Annual  Meeting and will have an  opportunity
to make a statement if such representative  desires to do so. The representative
of KPMG Peat Marwick LLP also will be  available to respond to questions  raised
during the meeting.

                                       15


<PAGE>



                              FINANCIAL STATEMENTS

     The  Company's  annual  report to  stockholders  for the fiscal  year ended
December 31, 1996,  containing audited consolidated balance sheets as of the end
of each of the past two fiscal  years and  audited  consolidated  statements  of
operations,  shareholders'  equity  and cash  flows  for each of the last  three
fiscal years, is being mailed with this proxy statement to stockholders entitled
to notice of the Annual Meeting.

                  SHAREHOLDER PROPOSALS FOR 1997 ANNUAL MEETING

     Under the applicable rules of the Securities and Exchange Commission, a
stockholder who wishes to submit a proposal for inclusion in the proxy statement
of the Board of Directors for the annual meeting of  stockholders  to be held in
the spring of 1998 must submit such  proposal in writing to the Secretary of the
Company at the Company's  principal  executive offices no later than January 19,
1998.

                                  OTHER MATTERS


     The Board knows of no other  matters  which will be presented to the Annual
Meeting.  If,  however,  any other  matter is properly  presented  at the Annual
Meeting, the proxy solicited by this Proxy Statement will be voted in accordance
with the judgment of the person or persons  holding such proxy. 

                              BY ORDER OF THE BOARD OF DIRECTORS,  



                              Julian N. Stern, Secretary 

Redwood City, California 
May 19, 1997


 YOU ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON. WHETHER OR NOT YOU
        PLAN TO ATTEND THE MEETING, YOU ARE REQUESTED TO SIGN AND RETURN
           THE ACCOMPANYING PROXY IN THE ENCLOSED POSTPAID ENVELOPE.


                                       16
<PAGE>

                         ADVANCED POLYMER SYSTEMS, INC.
                                 1992 STOCK PLAN


         1. Purpose.  The purpose of the Advanced  Polymer  Systems,  Inc., 1992
Stock Plan (the "Plan") is to attract, retain and motivate directors,  officers,
key employees and consultants of Advanced Polymer Systems, Inc. (the "Company"),
and its  subsidiaries  by giving them the opportunity to acquire stock ownership
in the Company.  Grants under this Plan may be either  incentive  stock  options
("ISOs")  intended to satisfy the  requirements  of Section 422 of the  Internal
Revenue Code of 1986, as amended (the  "Code"),  or  nonstatutory  stock options
("NSOs"), and this Plan and any options granted hereunder shall be appropriately
construed  to  conform to such  requirements.  This Plan also  provides  for the
direct sale of shares to eligible participants.

         2.  Effective  Date and  Term of Plan.  This  Plan was  adopted  by the
Company's  Board of Directors  (the  "Board") and became  effective on March 24,
1992. This Plan shall terminate  automatically 10 years after its effective date
unless terminated  earlier by the Board under Section 12. No options or purchase
rights  shall be granted  after  termination  of this Plan but all  options  and
purchase  rights  granted  prior  to  termination  shall  remain  in  effect  in
accordance with their terms.

         3.  Number  and Source of Shares  Subject  to the Plan.  Subject to the
provisions  of Section 10, the total  number of shares of stock with  respect to
which  options or purchase  rights may be granted  under this Plan is  3,250,000
shares of Common Stock, $.01 par value, of the Company (the "Stock"). The shares
covered by any terminated or expired option or purchase right or


<PAGE>


the  unexercised  portion  thereof shall become  available again for grant under
this  Plan.  The shares to be issued  hereunder  upon  exercise  of an option or
purchase right may consist of authorized and unissued shares or treasury shares.

         4.  Administration  of the Plan. The Plan shall be  administered by the
Board, or upon  delegation by the Board,  by a committee  consisting of not less
than  two  directors  (in  either  case,  the  "Administrator").  So long as not
otherwise  required for the Plan to comply with Rule 16b-3 under the  Securities
Exchange   Act  of  1934,   as   amended,   the   Administrator   may   delegate
nondiscretionary  administrative  duties to such  employees  of the Company or a
subsidiary  as it deems  proper.  The  Administrator  may also  make  rules  and
regulations  which it deems  useful to  administer  this Plan.  Any  decision or
action of the  Administrator  in  connection  with this Plan or any  options  or
purchase  rights granted or shares  purchased under this Plan shall be final and
binding.  No member of the Board  shall be liable  for any  decision,  action or
omission  respecting  this Plan,  or any options or purchase  rights  granted or
shares issued under this Plan. 

         5.  Persons  Eligible  to  Participate  in this  Plan.  

             (a) ISOs may be granted  under this Plan only to  employees  of the
Company or any  subsidiary of the Company,  including  employees who may also be
officers or directors of the Company or any subsidiary. NSOs and purchase rights
may be granted to  employees,  including  employees  who may also be officers or
directors,  directors,  consultants and potential employees (in contemplation of
employment) of the Company or any

                                       -2-

<PAGE>



subsidiary. All grants shall be made by the Administrator.  Determination by the
Administrator as to eligibility shall be conclusive.

             (b) Notwithstanding  any other provision of this Plan,  Nonemployee
Directors shall automatically  receive grants under this Plan in accordance with
this Section 5(b).  

                    (i) Subject to the terms and  conditions of this Plan,  when
any  Nonemployee  Director who has not previously  been a member of the Board is
first elected or appointed as a member of the Board,  then on the effective date
of such appointment or election the Company shall grant to such new Non-employee
Director an NSO to purchase 25,000 shares at an exercise price equal to the fair
market value of such shares on the date of such option grant.

                    (ii) Subject to the terms and  conditions  of this Plan,  on
the date of the first  meeting  of the Board  immediately  following  the annual
meeting  of  stockholders  of the  Company  (even if held on the same day as the
meeting of stockholders)  which is held more than 12 months after a Non-employee
Director is first elected or appointed to the Board,  commencing with the annual
meeting of stockholders  held in May 1992 (or, if no annual meeting is held that
month or, in the case of any year  after  1992,  if no  annual  meeting  is held
before the last business day of July of that year, then on the last business day
of July 1992 or of such other July, as the case may be), the Company shall grant
to each Nonemployee  Director then in office an NSO to purchase 10,000 shares at
an exercise  price equal to the fair market  value of such shares on the date of
such option grant.

                                       -3-

<PAGE>



                    (iii)  Subject to the other  provisions  of this Plan,  each
option  granted  pursuant to this  Section 5(b) shall be for a term of 10 years.
Each option granted under Section 5(b)(i) shall become  exercisable with respect
to  one-fourth  of the  number of shares  covered  by such  option on the first,
second,  third and fourth  anniversary  of the date such option was granted,  so
that such option shall be fully exercisable beginning on such fourth anniversary
of the date such option was granted.  Each option granted under Section 5(b)(ii)
shall be fully  exercisable  beginning on the first anniversary of the date such
option  was  granted.  

         6. Grant of Options.  The Administrator  may, in its discretion,  grant
options under this Plan at any time and from time to time before the  expiration
of 10 years  from the  effective  date of this  Plan.  The  Administrator  shall
specify  the date of grant or, if it fails  to,  the date of grant  shall be the
date of the  action  taken by the  Administrator  to grant the option (in either
case, the "Grant Date").  If an ISO is approved in anticipation of employment of
any  employee,  the Grant Date shall be the date the intended  optionee is first
treated as an employee of the Company or any subsidiary for payroll purposes. As
soon as practicable  after the Grant Date, the Company will provide the optionee
a written stock option agreement in the form approved by the Administrator  (the
"Option  Agreement"),  which  designates  the  option  as an ISO or an NSO,  and
identifies  the Grant Date, the number of shares of Stock covered by the option,
the option price and the other terms and conditions of the option.

                                       -4-

<PAGE>



         7. Terms and  Conditions  of Options.  Options  granted under this Plan
shall be subject to the following  terms and conditions and such other terms and
conditions not inconsistent with this Plan as the Administrator may impose:  

             (a)  Exercise of Option.  In order to exercise  all or a portion of
any option  granted  under this Plan, an optionee must remain as an employee (in
the case of an ISO), or as an employee,  officer, director or consultant (in the
case of an NSO) of the Company or a subsidiary  of the Company until the date on
which the option or portion thereof,  becomes  exercisable (the "Vesting Date").
The option  shall be  partially  exercisable  on or after each Vesting Date with
respect to the  percentage  of total shares  covered by the option as set out in
the Option Agreement.

             If an option (or portion  thereof) is not exercised on the earliest
Vesting Date on which it becomes exercisable,  it may be exercised,  in whole or
in part, prior to its expiration date; provided, however, that no option granted
under this Plan may be exercised  more than 10 years from the Grant Date. If, at
the time the Company grants an ISO, the optionee directly or by attribution owns
stock possessing more than 10% of the total combined voting power of all classes
of stock of the Company or any subsidiary, the ISO shall not be exercisable more
than five years after the Grant Date.

             Notwithstanding  any other  provisions  of this Plan, to the extent
required by Section 422 of the Code,  the aggregate  fair market value of Common
Stock first  becoming  exercisable by an optionee in any calendar year under all
ISOs granted to the optionee  together  with all other  incentive  stock options
granted

                                       -5-

<PAGE>



to such optionee  covering  stock of the Company (or any company  which,  at the
time of grant,  was a parent or  subsidiary  of the  Company)  shall not  exceed
$100,000  (or such other  amount as may be in effect from time to time).  If, by
their terms such ISOs and other  incentive  stock options,  when taken together,
would first  become  exercisable  at a rate which would  exceed such limit then,
unless  otherwise  provided in the Option  Agreement,  the portion thereof which
exceeds  such limit  shall be NSOs.  For this  purpose,  value shall be the fair
market value of the Common Stock when the options were granted and options shall
be taken into account in the order in which they were granted.
             
             (b) Option  Price.  The option  price shall be at least 100% of the
fair  market  value of the shares  covered by the option on the Grant  Date,  as
determined  in good  faith by the  Administrator.  If,  at the time the  Company
grants an ISO, the optionee  directly or by  attribution  owns stock  possessing
more than 10% of the total combined  voting power of all classes of stock of the
Company or any  subsidiary,  the option price shall be at least 110% of the fair
market value of the shares  covered by the ISO on the Grant Date  determined  in
the same  manner.  

             (c) Method of Exercise.  To the extent the right to purchase shares
has accrued,  an option (or portion  thereof) may be exercised from time to time
in accordance  with its terms by written notice from the optionee to the Company
stating the number of shares with respect to which the option is being exercised
and accompanied by payment in full of the exercise price of the shares.  Payment
may  be  made  in  cash,  by  check  or,  at  the  absolute  discretion  of  the
Administrator, by delivery of

                                       -6-

<PAGE>



an interest-bearing,  full recourse promissory note or shares of Common Stock of
the Company,  endorsed in favor of the Company or  accompanied by an appropriate
stock  power,  or  by  a  combination  of  the  above,  or  any  other  form  of
consideration  approved by the  Administrator  (including  payment in accordance
with any cashless  exercise  program  permitted by  applicable  law,  including,
without  limitation  Regulation T promulgated by the Federal  Reserve Board,  as
amended from time to time).  Any share  delivered to the Company as payment upon
exercise of an option  shall be valued at the fair  market  value on the date of
exercise of the option determined in good faith by the Administrator.

             (d) Nonassignability of Option Rights.  Except as determined by the
Administrator in its absolute discretion,  no option shall be transferable other
than by will or by the laws of descent and distribution and, during the lifetime
of an optionee,  only the optionee  may exercise an option.  

             (e) Exercise After  Termination or Death.  If, for any reason other
than permanent and total  disability or death, an optionee ceases to be employed
by or to serve as a  consultant  to or a director of the Company or a subsidiary
(if such relationship  forms the sole basis for the option grant),  options held
at the  date of  such  termination  (to  the  extent  then  exercisable)  may be
exercised  in whole or in part at any time within 30 days after the date of such
termination  (but in no event  after the  expiration  date of the  option as set
forth  in  the  Option  Agreement).  Notwithstanding,  if  an  optionee  becomes
permanently and totally  disabled (within the meaning of Section 22(e)(3) of the
Code) or dies while employed by or serving as a

                                       -7-

<PAGE>



consultant  to or director of the Company or a  subsidiary  (or, if the optionee
dies within the period that the option remains  exercisable after termination of
employment, consultancy or directorship),  options then held (to the extent then
exercisable)  may  be  exercised  by  the  optionee,   the  optionee's  personal
representative,  or by the person to whom the option is  transferred  by will or
the laws of descent and distribution in whole or in part, at any time within one
year after the disability or death or any lesser period  specified in the Option
Agreement (but in no event after the expiration  date of the option as set forth
in the Option Agreement).

             (f)  Compliance  with  Securities  Laws.  The Company  shall not be
obligated to issue any shares upon  exercise of an option  unless the shares are
at that time  effectively  registered  or  exempt  from  registration  under the
federal  securities  laws and the offer and sale of the shares are  otherwise in
compliance  with all  applicable  securities  laws.  The  Company  shall have no
obligation to register the shares under the federal  securities  laws or to take
any other  steps  necessary  to enable the  shares to be offered  and sold under
federal or other  securities  laws.  Upon  exercising  all or any  portion of an
option, an optionee may be required to furnish  representations  or undertakings
deemed  appropriate  by the  Company  to enable the offer and sale of the option
shares or  subsequent  transfers  of any  interest  in the shares to comply with
applicable  securities laws. Stock certificates  evidencing shares acquired upon
exercise of options shall bear any legend required by, or useful for purposes of

                                       -8-

<PAGE>



compliance with,  applicable  securities laws, this Plan or the Option Agreement
evidencing the option.

         8.  Purchase Rights.

             (a) Grant. The Administrator may, in its discretion,  permit direct
sales of Common Stock under this Plan at any time before  expiration of 10 years
from the effective  date of this Plan.  Shares may be issued at a price not less
than the fair  market  value on the date of sale,  payable  at the option of the
Administrator  in cash or other  lawful  consideration.  As soon as  practicable
after the grant of a purchase right, the Administrator  shall advise the grantee
in writing of the terms,  conditions  and  restrictions  relating  to the grant,
including the number of shares, the purchase price, the method of payment (which
may include,  in the absolute  discretion of the  Administrator,  delivery of an
interest-bearing,  full  recourse  promissory  note),  the time within which the
purchase right must be exercised, and the repurchase right, if any, available to
the Company. 

             (b) Purchase Agreement.  Each sale of shares pursuant to a purchase
right shall be evidenced by an agreement  between the  purchaser and the Company
in such form and  containing  such terms,  conditions  and  restrictions  as are
approved  by the  Administrator,  which  agreement  need  not be  identical  for
different purchasers.  Stock certificates evidencing shares acquired pursuant to
a purchase  right shall bear any legend  required  by, or useful for purposes of
compliance  with,  applicable  securities  laws,  this  Plan  or  the  agreement
evidencing the purchase right.

                                       -9-

<PAGE>



         9. Payment of Taxes. Regardless of the form of payment,  exercise of an
option may be conditioned on payment in cash, or provision  satisfactory  to the
Administrator  for  payment  to the  Company,  of all local,  state and  federal
withholding  taxes  which,  in the  Administrator's  judgment,  are  payable  in
connection therewith.

         If and to the extent  consented  to by the  Administrator,  in its sole
discretion, an optionee who has exercised an option may make an election to: (a)
tender  previously-owned  shares  of  Stock;  or (b) have  shares of Stock to be
obtained  upon  exercise  of an option  withheld by the Company on behalf of the
optionee,  to pay the amount of tax that the  Administrator,  in its discretion,
determines is required to be withheld by the Company as a result of the exercise
of such option. 

         10.  Adjustment  for  Changes  in  Capitalization.   The  existence  of
outstanding  options shall not affect the Company's right to effect adjustments,
recapitalizations,  reorganizations  or  other  changes  in  its  or  any  other
corporation's  capital structure or business,  any merger or consolidation,  any
issuance of bonds,  debentures,  preferred or prior preference stock ahead of or
affecting the Stock,  the  dissolution  or  liquidation  of the Company's or any
other  corporation's  assets or  business  or any other  corporate  act  whether
similar to the events  described  above or otherwise.  Subject to Section 11, if
the  outstanding  shares of the Stock are  increased  or  decreased in number or
changed into or exchanged  for a different  number or kind of  securities of the
Company   or  any  other   corporation   by   reason   of  a   recapitalization,
reclassification, stock split, combination of shares, stock

                                      -10-

<PAGE>


dividend or other event, the number and kind of securities with respect to which
options may be granted under this Plan,  the number and kind of securities as to
which  outstanding  options  may be  exercised,  and the  option  price at which
outstanding options may be exercised,  may be adjusted in the sole discretion of
the  Administrator  and without regard to any resulting tax  consequences to the
optionee.

         11. Dissolution,  Liquidation, Merger. In the event of a dissolution or
liquidation of the Company,  a merger or  consolidation  in which the Company is
not the  surviving  corporation,  a reverse  merger in which the  Company is the
surviving  corporation  but in which  more than 50% of the  shares of its Common
Stock  outstanding  before  the merger are held,  after the  merger,  by holders
different from those  immediately  prior to the merger, or a sale of over 80% of
the assets of the Company,  the Administrator may, in its discretion,  do one or
more of the following with respect to each outstanding option upon not less than
10 days prior written notice to the optionee:
                 
             (a) accelerate the vesting of such option (subject,  in the case of
ISOs, to the limitation set forth in Section 7(a) of this Plan); 

             (b) cancel such option to the extent then  exercisable upon payment
in cash to the  optionee  of the  amount by which  any cash and the fair  market
value  of  any  other  property  which  the  optionee  would  have  received  as
consideration  for the shares issuable on exercise of the option, if such option
had been exercised before such liquidation, dissolution, merger,

                                      -11-

<PAGE>



consolidation,  reverse merger or sale, exceeds the exercise price thereof;  

             (c) shorten  the period  during  which such option is  exercisable,
provided  such  option  shall  remain  exercisable,   to  the  extent  otherwise
exercisable,  for at least 10 days  after the date the  notice is given;  or 

             (d)  arrange  for new  option  rights  to be  substituted  for such
option,  or for the Company's  obligations as to such option to be assumed by an
employer corporation other than the Company or by a parent or subsidiary of such
employer  corporation.  The  action  described  in this  Section 11 may be taken
without regard to any resulting tax  consequences to the optionee and may differ
with respect to different  options.  

         12. Rights as Shareholder;  Employee.  An optionee shall have no rights
as a shareholder with respect to any shares covered by an option until the stock
certificates  representing  the shares are actually  delivered to the  optionee.
Subject to  Sections 10 and 11, no  adjustment  shall be made for  dividends  or
other rights for which the record date is prior to the date the certificates are
delivered.  The grant of any option  shall not, by itself,  confer on any person
any right or inference of continued  employment by, consultancy to or membership
on the Board of Directors of the Company.

         13. Disqualifying  Dispositions.  If Stock acquired upon exercise of an
Incentive Stock Option is disposed of in a disqualifying  disposition within the
meaning of Section 422 of the Code, the holder of the Stock immediately prior to
the

                                      -12-

<PAGE>



disposition  shall  notify  the  Company in writing of the date and the terms of
such disposition and comply with any other  requirements  imposed by the Company
in order to enable the Company to secure the  related  income tax  deduction  to
which it is entitled.

         14. Termination or Amendment. The Board may amend, alter or discontinue
the Plan or any option  grant,  but no amendment,  alteration or  discontinuance
shall  be  made  which  would  impair  the  rights  of a  participant  under  an
outstanding  option  grant  without the  participant's  consent.  No  amendment,
alteration or discontinuance shall require stockholder approval,  except: (a) an
increase in the total number of shares reserved for issuance under the Plan; (b)
with respect to provisions solely as they relate to Incentive Stock Options,  to
the extent  required for the Plan to comply with Section 422 of the Code; (c) to
the extent required by other  applicable  laws,  regulations or rules; or (d) to
the extent the Board otherwise concludes that stockholder approval is advisable.
         
         15.  Parent  and  Subsidiary.  As  used  in  this  Plan,  "parent"  and
"subsidiary"  mean any  corporation in an unbroken chain of  corporations  which
includes the Company if, at the relevant time,  each of the  corporations  other
than the last  corporation in the chain owns stock  possessing  more than 50% of
the total  combined  voting  power of all  classes  of stock of one of the other
corporations in the chain.
       
         16.  Rule  16b-3.  Notwithstanding  any  provision  of the Plan,  it is
intended  that option  grants  shall  always be granted and  exercised in such a
manner as to conform to the provisions of

                                      -13-

<PAGE>


Rule 16b-3.  Notwithstanding  the foregoing,  it shall be the  responsibility of
persons  subject to Section 16 of the  Exchange  Act,  not of the Company or the
Administrator,  to comply with the  requirements  of Section 16 of the  Exchange
Act; and neither the Company nor the Administrator  shall be liable if this Plan
or any  transaction  under  this  Plan  fails  to  comply  with  the  applicable
conditions  of Rule 16b-3,  or if any such  person  incurs any  liability  under
Section 16 of the Exchange Act.

         17.  Governing  Law. This Plan and the rights of all persons under this
Plan shall be construed in accordance  with and under  applicable  provisions of
the  Internal  Revenue  Code of 1986,  as amended,  and the laws of the State of
California.

         The Board  originally  adopted  this Plan on March  24,  1992,  and the
Company's shareholders approved it on May 19, 1992.

         The Plan was amended to  increase  the number of shares  available  for
grant from  2,500,000  to  3,250,000  on January  11,  1996,  and the  Company's
shareholders approved of such amendment on June 5, 1996.



                                      -14-





<PAGE>


                         ADVANCED POLYMER SYSTEMS, INC.

                        1997 EMPLOYEE STOCK PURCHASE PLAN


         1. PURPOSE.  This Advanced  Polymer  Systems,  Inc. 1997 Employee Stock
Purchase Plan is designed to encourage and assist  employees of Advanced Polymer
Systems,  Inc. and  participating  subsidiaries to acquire an equity interest in
the Company through the purchase of shares of Company common stock.

         2. DEFINITIONS. As used herein, the following definitions shall apply:

                  (a) "Administrator" shall mean the entity, either the Board or
the committee of the Board, responsible for administering this Plan, as provided
in Section 3.

                  (b) "Board"  shall mean the Board of Directors of the Company,
as constituted from time to time.

                  (c) "Code"  shall mean the Internal  Revenue Code of 1986,  as
amended from time to time, and any successor statute.

                  (d) "Company"  shall mean Advanced  Polymer  Systems,  Inc., a
Delaware corporation, and Participating Subsidiaries.

                  (e)  "Common  Stock"  shall  mean the Common  Stock,  $.01 par
value, of the Company.

                  (f) "Employee" shall mean any individual who is an employee of
the Company or a Participating  Subsidiary within the meaning of Section 3401(c)
of the Code and the Treasury Regulations thereunder.

                  (g)  "Enrollment  Date"  shall have the  meaning  set forth in
Section 6.

                  (h) "Fair market  value"  means as of any given date:  (i) the
closing price of the Common Stock on the Nasdaq  National  Market as reported in
the Wall Street Journal;  or (ii) if the Common Stock is no longer quoted on the
Nasdaq National Market, but is listed on an established stock exchange or quoted
on any other established interdealer quotation system, the closing price for the
Common Stock on such exchange or system, as reported in the Wall Street Journal;
or (iii) in the absence of an established  market for the Common Stock, the fair
market  value of the Common Stock as  determined  by the  Administrator  in good
faith.

                  (i) "Lower Price  Enrollment  Date" shall have the meaning set
forth in Section 6.

                  (j)  "Option  Period"  shall  have the  meaning  set  forth in
Section 7(b).

<PAGE>

                  (k)  "Participating  Subsidiary" shall mean a Subsidiary which
has been designated by the Administrator as covered by the Plan.

                  (l) "Plan" shall mean this Advanced Polymer Systems, Inc. 1997
Employee Stock Purchase Plan, as it may be amended from time to time.

                  (m)  "Purchase  Date"  shall  have the  meaning  set  forth in
Section 9(a).

                  (n) "Section" unless the context clearly indicates  otherwise,
shall refer to a Section of this Plan.

                  (o) "Subsidiary" shall mean a "subsidiary  corporation" of the
Company, whether now or hereafter existing, within the meaning of Section 424(f)
of the Code, but only for so long as it is a "subsidiary corporation."

                  (p)  "Trading  Day"  means  any day on which  regular  trading
occurs on any  established  stock  exchange or market system on which the Common
Stock is traded.

         3. ADMINISTRATION.

                  (a) Administrator. The Plan shall be administered by the Board
or, upon  delegation by the Board,  by a committee of the Board (in either case,
the  "Administrator").  In connection with the  administration  of the Plan, the
Administrator  shall have the powers possessed by the Board.  The  Administrator
may act only by a  majority  of its  members.  The  Administrator  may  delegate
administrative  duties to such  employees of the Company as it deems proper,  so
long as such  delegation  is not  otherwise  prohibited  by Rule 16b-3 under the
Securities  Exchange Act of 1934, as amended, or other applicable law. The Board
at any time may terminate the authority  delegated to any committee of the Board
pursuant to this Section 3(a) and revest in the Board the  administration of the
Plan.

                  (b) Administrator  Determinations  Binding.  The Administrator
may adopt,  alter and repeal  administrative  rules,  guidelines  and  practices
governing the Plan and the options  granted under it as it shall deem  advisable
from time to time,  may interpret  the terms and  provisions of the Plan and the
Options granted under it, may correct any defect,  omission or  inconsistency in
the Plan or in any Option; and may otherwise supervise the administration of the
Plan and the Options granted under it. The  Administrator  may establish,  under
guidelines from the Board, limits on the number of shares which may be purchased
by each  participant  on an annual or other  periodic  basis or on the number of
shares which may be purchased on any Purchase  Date.  All decisions  made by the
Administrator  under the Plan  shall be binding on all  persons,  including  the
Company and all participants in the Plan. No member of the Administrator shall

                                       -2-
<PAGE>

be liable  for any action  that he or she has in good  faith  taken or failed to
take with respect to this Plan.

         4. NUMBER OF SHARES.

                  (a) The Company has  reserved  for sale under the Plan 400,000
shares of Common Stock. Shares sold under the Plan may be newly issued shares or
shares  reacquired in private  transactions  or open market  purchases,  but all
shares sold under the Plan,  regardless of source,  shall be counted against the
400,000 share  limitation.  If at any Purchase Date, the shares  available under
the Plan are less than the number all  participants  would otherwise be entitled
to  purchase  on such  date,  purchases  shall  be  reduced  proportionately  to
eliminate  the  deficit.  If, at any  Purchase  Date,  the  shares  which may be
purchased by a participant are restricted on account of a limit on the aggregate
shares which may be purchased per employee, purchases under each option shall be
reduced  proportionately.  Any funds that  cannot be applied to the  purchase of
shares due to such  reductions  shall be  refunded  to  participants  as soon as
administratively feasible.

                  (b) In the  event  of  any  reorganization,  recapitalization,
stock split, reverse stock split, stock dividend, combination of shares, merger,
consolidation,  offering  of  rights,  or other  similar  change in the  capital
structure  of the  Company,  the Board may make such  adjustment,  if any, as it
deems  appropriate  in the  number,  kind,  and  purchase  price  of the  shares
available  for  purchase  under  the Plan and in the  maximum  number  of shares
subject to any option under the Plan.

         5. ELIGIBILITY REQUIREMENTS.

                  (a) Each  Employee of the Company,  except those  described in
the  next  paragraph,  shall  become  eligible  to  participate  in the  Plan in
accordance  with  Section  6 on  the  first  Enrollment  Date  on  or  following
commencement of his or her employment by the Company or following such period of
employment  as  is  designated   by  the   Administrator   from  time  to  time.
Participation in the Plan is entirely voluntary.

                  (b) The following Employees are not eligible to participate in
the Plan:

                           (i) Employees who would,  immediately upon enrollment
in the Plan,  own directly or  indirectly,  or hold options or rights to acquire
stock  possessing,  five percent (5%) or more of the total combined voting power
or  value  of all  classes  of stock of the  Company  or any  subsidiary  of the
Company; and

                           (ii)  Employees who are  customarily  employed by the
Company  fewer than  twenty (20) hours per week or fewer than five (5) months in
any calendar year.


                                       -3-

<PAGE>

         6.  ENROLLMENT.  Any  eligible  employee may enroll or re-enroll in the
Plan each year as of the close of the first trading day of: (a) May and November
of each such year;  or (b) such other  days as may be  established  by the Board
from time to time (the "Enrollment Dates");  provided, that the first Enrollment
Date shall be April 30,  1997.  In order to enroll,  an eligible  employee  must
complete,  sign,  and submit to the Company an enrollment  form.  Any enrollment
form  received  by the  Company  by the  20th  day of  the  month  preceding  an
Enrollment  Date (or by the Enrollment Date in the case of employees hired after
such 20th day or in the case of the first  Enrollment  Date), or such other date
established by the  Administrator  from time to time,  will be effective on that
Enrollment  Date.  In  addition,   the  Administrator  may  re-enroll   existing
participants  in the Plan on any  Enrollment  Date (the "Lower Price  Enrollment
Date") on which the fair market value of the Common Stock is lower than the fair
market value on such participant's  existing  Enrollment Date. A participant may
elect not to  re-enroll  on a Lower  Price  Enrollment  Date by filing a written
statement  with the Company  declaring  such  election  prior to the Lower Price
Enrollment Date.

         7. GRANT OF OPTION ENROLLMENT.

                  (a) Enrollment or  re-enrollment  by a participant in the Plan
on an  Enrollment  Date  will  constitute  the  grant  by  the  Company  to  the
participant  of an option to  purchase  shares of Common  Stock from the Company
under the Plan. Any  participant  whose option expires and who has not withdrawn
from the Plan will  automatically  be  re-enrolled in the Plan and granted a new
option on the Enrollment Date immediately following the date on which the option
expires.

                  (b) Except as provided  in Section  10,  each  option  granted
under the Plan shall have the following terms:

                           (i) the  option  will  have a term of not  more  than
twenty-four  (24) months or such shorter  option period as may be established by
the  Board  from  time  to  time  (the  "Option  Period").  Notwithstanding  the
foregoing,  however,  whether or not all shares have been purchased  thereunder,
the option  will expire on the  earlier to occur of: (A) the  completion  of the
purchase of shares on the last Purchase Date occurring  within  twenty-four (24)
months after the Enrollment Date for such option,  or such shorter option period
as may be established by the Board before an Enrollment  Date for all options to
be granted on such date; or (B) the date on which the  employee's  participation
in the Plan terminates for any reason;

                           (ii)  payment for shares  purchased  under the option
will be made only through payroll withholding in accordance with Section 8;

                           (iii)  purchase of shares upon exercise of the option
will be effected  only on the Purchase  Dates  established  in  accordance  with
Section 9;

                                       -4-

<PAGE>


                           (iv) the option,  if not altered,  amended or revoked
by the Company prior to the relevant  Purchase Date, may be accepted only by (x)
there having been withheld from the  compensation  of the employee in accordance
with the terms of the Plan  amounts  sufficient  to  purchase  the Common  Stock
intended to be purchased  under the option,  and (y) the employee being employed
by the Company and not having  withdrawn from the Plan on the relevant  Purchase
Date.

                           (v) the  price per share  under  the  option  will be
determined as provided in Section 9;

                           (vi) the  maximum  number  of  shares  available  for
purchase under an option for each one percent (1%) of compensation designated by
an employee in accordance with Section 8 will,  unless otherwise  established by
the Board before an Enrollment  Date for all options to be granted on such date,
be determined by dividing  $25,000 by the fair market value of a share of Common
Stock on the  Enrollment  Date,  dividing  the result by the  maximum  number of
percentage  points that an employee may  designate  under  Section 8 at the time
such option is  granted,  and  multiplying  the result by the number of calendar
years included in whole or in part in the period from grant to expiration of the
option;

                           (vii)  the  option  (taken  together  with all  other
options then  outstanding  under this and all other similar stock purchase plans
of the Company and any subsidiary of the Company,  collectively  "Options") will
in no event  give the  participant  the right to  purchase  shares at a rate per
calendar  year which  accrues in excess of $25,000 of fair market  value of such
shares,  less the fair market value of any shares accrued and already  purchased
during such year under Options which have expired or  terminated,  determined at
the applicable Enrollment Dates; and

                           (viii) the option will in all  respects be subject to
the terms and conditions of the Plan, as interpreted by the  Administrator  from
time to time.

         8. PAYROLL AND TAX WITHHOLDING; USE BY COMPANY.

                  (a) Each participant shall elect to have amounts withheld from
his or her compensation  paid by the Company during the Option Period, at a rate
equal to any whole  percentage  up to a maximum of ten  percent  (10%),  or such
lesser  percentage  as the  Board  may  establish  from  time to time  before an
Enrollment  Date.  Compensation  includes  regular salary  payments,  annual and
quarterly  bonuses,  hire-on  bonuses,  cash  recognition  awards,  commissions,
overtime pay, shift premiums,  and elective  contributions by the participant to
qualified  employee  benefit plans,  but excludes all other payments  including,
without limitation,  long-term disability or workers compensation  payments, car
allowances,    employee   referral   bonuses,   relocation   payments,   expense
reimbursements (including but not limited to travel,  entertainment,  and moving
expenses), salary gross-up

                                       -5-
<PAGE>

payments,  and non-cash  recognition  awards.  The participant shall designate a
rate of withholding  in his or her enrollment  form and may elect to increase or
decrease  the rate of  contribution  effective  as of any  Enrollment  Date,  by
delivery to the  Company,  not later than ten (10) days  before such  Enrollment
Date, of a written notice indicating the revised withholding rate.

                  (b)  Payroll  withholdings  shall be  credited  to an  account
maintained  for purposes of the Plan on behalf of each  participant,  as soon as
administratively  feasible after the  withholding  occurs.  The Company shall be
entitled  to use the  withholdings  for any  corporate  purpose,  shall  have no
obligation to pay interest on withholdings to any participant,  and shall not be
obligated to segregate withholdings.

                  (c) Upon  disposition  of shares  acquired  by  exercise of an
option, the participant shall pay, or make provision adequate to the Company for
payment of, all federal,  state, and other tax (and similar)  withholdings  that
the Company determines, in its discretion,  are required due to the disposition,
including any such withholding that the Company  determines in its discretion is
necessary  to allow the  Company to claim tax  deductions  or other  benefits in
connection  with  the  disposition.   A  participant  shall  make  such  similar
provisions  for payment  that the Company  determines,  in its  discretion,  are
required  due to the exercise of an option,  including  such  provisions  as are
necessary  to allow the  Company to claim tax  deductions  or other  benefits in
connection with the exercise of the option.

         9. PURCHASE OF SHARES.

                  (a)  On  the  last  Trading  Day   immediately   preceding  an
Enrollment Date (other than the first Enrollment Date), or on such other days as
may be  established  by the Board from time to time prior to an Enrollment  Date
for all options to be granted on such Enrollment Date (each a "Purchase  Date"),
the Company  shall apply the funds then credited to each  participant's  payroll
withholdings  account to the purchase of whole shares of Common Stock.  The cost
to the participant  for the shares  purchased under any option shall be not less
than eighty-five percent (85%) of the lower of:

                           (i) the fair market  value of the Common Stock on the
Enrollment Date for such option; or

                           (ii) the fair market value of the Common Stock on the
date such option is exercised.

                  (b) Any funds in an amount  less than the cost of one share of
Common Stock left in a participant's  payroll withholdings account on a Purchase
Date  shall be carried  forward  in such  account  for  application  on the next
Purchase Date.

                  (c)  Notwithstanding  the  terms  of  Section  9(a),  no funds
credited to any employee's payroll withholdings account

                                       -6-
<PAGE>

shall be used to  purchase  Common  Stock on any date prior to the date that the
Plan has been approved by the  stockholders of the Company,  as noted in Section
21. If such approval is not  forthcoming  within one year from the date that the
Plan was  approved  by the Board of  Directors,  all amounts  withheld  shall be
distributed to the participants as soon as administratively feasible.

         10.  WITHDRAWAL FROM THE PLAN. A participant may withdraw from the Plan
in full (but not in part) at any time, effective after written notice thereof is
received by the Company. Unless the Administrator elects to permit a withdrawing
participant  to invest funds credited to his or her  withholding  account on the
Purchase Date immediately following notice of withdrawal,  all funds credited to
a participant's  payroll withholdings account shall be distributed to him or her
without  interest  within sixty (60) days after notice of withdrawal is received
by the Company. Any eligible employee who has withdrawn from the Plan may enroll
in the Plan  again on any  subsequent  Enrollment  Date in  accordance  with the
provisions of Section 6.

         11.  TERMINATION OF EMPLOYMENT.  Participation  in the Plan  terminates
immediately  when a  participant  ceases to be  employed  by the Company for any
reason   whatsoever   (including  death  or  disability)  or  otherwise  becomes
ineligible  to  participate  in the Plan. As soon as  administratively  feasible
after  termination,  the  Company  shall  pay to the  participant  or his or her
beneficiary or legal  representative,  all amounts credited to the participant's
payroll withholdings account; provided, however, that if a participant ceases to
be employed by the Company  because of the  commencement  of  employment  with a
Subsidiary  of the Company that is not a  Participating  Subsidiary,  funds then
credited to such participant's  payroll withholdings account shall be applied to
the purchase of whole shares of Common Stock at the next  Purchase  Date and any
funds remaining after such purchase shall be paid to the participant.

         12. DESIGNATION OF BENEFICIARY.

                  (a) Each  participant may designate one or more  beneficiaries
in the  event of death  and may,  in his or her  sole  discretion,  change  such
designation at any time. Any such designation shall be effective upon receipt in
written form by the Company and shall  control over any  disposition  by will or
otherwise.

                  (b) As soon as administratively  feasible after the death of a
participant, amounts credited to his or her account shall be paid in cash to the
designated  beneficiaries or, in the absence of a designation,  to the executor,
administrator,  or other legal representative of the participant's  estate. Such
payment shall relieve the Company of further  liability with respect to the Plan
on  account  of the  deceased  participant.  If more  than  one  beneficiary  is
designated, each beneficiary shall

                                       -7-
<PAGE>

receive an equal portion of the account unless the participant has given express
contrary written instructions.

         13. ASSIGNMENT.

                  (a) The  rights of a  participant  under the Plan shall not be
assignable by such participant, by operation of law or otherwise. No participant
may create a lien on any funds,  securities,  rights,  or other property held by
the  Company for the account of the  participant  under the Plan,  except to the
extent that there has been a designation of beneficiaries in accordance with the
Plan, and except to the extent permitted by the laws of descent and distribution
if beneficiaries have not been designated.

                  (b) A  participant's  right to purchase  shares under the Plan
shall be exercisable only during the  participant's  lifetime and only by him or
her,  except that a participant may direct the Company in the enrollment form to
issue share  certificates  to the participant and his or her spouse in community
property,  to the participant  jointly with one or more other persons with right
of survivorship, or to certain forms of trusts approved by the Administrator.

         14. ADMINISTRATIVE  ASSISTANCE.  If the Administrator in its discretion
so elects, it may retain a brokerage firm, bank, or other financial  institution
to  assist  in  the   purchase  of  shares,   delivery  of  reports,   or  other
administrative  aspects  of the  Plan.  If the  Administrator  so  elects,  each
participant  shall  (unless  prohibited  by the laws of the nation of his or her
employment  or  residence)  be  deemed  upon  enrollment  in the  Plan  to  have
authorized  the  establishment  of an  account  on  his or her  behalf  at  such
institution.  Shares purchased by a participant  under the Plan shall be held in
the account in the name in which the share certificate would otherwise be issued
pursuant to Section 13(b).

         15. COSTS. All costs and expenses  incurred in  administering  the Plan
shall be paid by the  Company,  except that any stamp  duties or transfer  taxes
applicable  to  participation  in the Plan may be charged to the account of such
participant  by the Company.  Any brokerage fees for the purchase of shares by a
participant  shall be paid by the Company,  but brokerage fees for the resale of
shares by a participant shall be borne by the participant.

         16. EQUAL RIGHTS AND  PRIVILEGES.  All  eligible  employees  shall have
equal rights and privileges  with respect to the Plan so that the Plan qualifies
as an "employee  stock  purchase  plan" within the meaning of Section 423 of the
Code and the related  Treasury  Regulations.  Any provision of the Plan which is
inconsistent with Section 423 of the Code shall without further act or amendment
by the  Company or the Board be  reformed  to comply  with the  requirements  of
Section 423. This Section 16 shall take precedence over all other  provisions of
the Plan.

                                       -8-
<PAGE>

         17.  APPLICABLE LAW. The Plan shall be governed by the substantive laws
(excluding the conflict of laws rules) of the State of California.

         18. MODIFICATION AND TERMINATION.

                  (a) The Board may amend,  alter,  or terminate the Plan at any
time,  including  amendments to outstanding  options. No amendment shall require
stockholder approval, except:

                           (i) for an increase in the number of shares  reserved
for purchase under the Plan;

                           (ii) to the  extent  required  for the Plan to comply
with Section 423 of the Code;

                           (iii) to the  extent  required  by  other  applicable
laws, regulations or rules; or

                           (iv) to the extent the Board otherwise concludes that
stockholder approval is advisable.

                  (b) In the event the Plan is  terminated,  the Board may elect
to terminate all  outstanding  options either  immediately or upon completion of
the purchase of shares on the next Purchase Date, or may elect to permit options
to expire in accordance with their terms (and  participation to continue through
such expiration  dates). If the options are terminated prior to expiration,  all
funds  contributed to the Plan that have not been used to purchase  shares shall
be returned to the participants as soon as administratively feasible.

                  (c) In the  event of the sale of all or  substantially  all of
the assets of the  Company,  or the merger of the Company  with or into  another
corporation,  or the  dissolution  or  liquidation  of the Company,  each option
outstanding  under  the  Plan  shall  be  assumed  by  any  purchaser  of all or
substantially  all of the assets of the Company or by a  successor  by merger to
the Company (or the parent company of such purchaser or successor) in compliance
with Section 424 of the Code, unless otherwise provided by the Board in its sole
discretion,  in which event, a Purchase Date shall occur immediately  before the
effective date of such event.

         19.  RIGHTS AS AN  EMPLOYEE.  Nothing in the Plan shall be construed to
give any person  the right to remain in the  employ of the  Company or to affect
the Company's  right to terminate the  employment of any person at any time with
or without cause.

         20. RIGHTS AS A SHAREHOLDER; DELIVERY OF CERTIFICATES. Unless otherwise
determined  by  the  Board,  certificates  evidencing  shares  purchased  on any
Purchase  Date shall be  delivered  to a  participant  only if he or she makes a
written  request  to the  Administrator.  Participants  shall be  treated as the
owners of their shares effective as of the Purchase Date.

                                       -9-

<PAGE>

         21. BOARD AND SHAREHOLDER APPROVAL.  The Plan was approved by the Board
of  Directors  on March 5, 1997,  and by the  holders of a majority of the votes
cast at a duly held shareholders'  meeting on _______________,  1997, at which a
quorum of the voting power of the Company was represented in person or by proxy.




                                      -10-

<PAGE>


                         ADVANCED POLYMER SYSTEMS, INC.
                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 18, 1997

         The  undersigned  hereby  appoints  John J. Meakem,  Jr., and Julian N.
Stern,  or  either  of  them,  each  with  full  power of  substitution,  as the
proxyholder(s)  of the  undersigned  to represent the  undersigned  and vote all
shares of the Common Stock of Advanced  Polymer  Systems,  Inc. (the "Company"),
which the  undersigned  would be entitled to vote if  personally  present at the
annual  meeting of  stockholders  of the  Company at the Park Hyatt  Hotel,  333
Battery Street,  San Francisco,  California at 10:00 a.m. local time on June 18,
1997, and at any adjournments or postponements of such meeting, as follows:

         The  Board of  Directors  recommends  that  you vote FOR the  following
proposals.  This  proxy,  when  properly  executed,  will be voted in the manner
directed. WHEN NO CHOICE IS INDICATED THIS PROXY WILL BE VOTED FOR THE FOLLOWING
PROPOSAL. This proxy may be revoked by the undersigned at any time, prior to the
time it is  voted,  by any of the  means  described  in the  accompanying  proxy
statement.

    [X]  Please mark 
         votes as in
         this example.

PLEASE COMPLETE, DATE AND SIGN THIS PROXY AND RETURN IT PROMPTLY IN THE ENCLOSED
ENVELOPE.

1. To elect as directors,  to hold office until 1998 and until their  successors
are elected, the eight nominees listed below:

Nominees:  Carl Ehmann,  Jorge Heller,  John J. Meakem, Jr., Peter Riepenhausen,
Toby  Rosenblatt,  Gregory H. Turnbull,  Charles  Anthony  Wainwright and Dennis
Winger

                     [ ]    FOR                        [ ]   WITHHELD
                            ALL                              FROM ALL
                         NOMINEES                            NOMINEES



[ ] ________________________________________
    For all nominees except as noted above

2. To approve an amendment to the Company's  1992 Stock Plan to limit the number
of shares with  respect to which  options may be granted to no more than 250,000
shares to any one participant in any one-year period.

                      FOR           AGAINST        ABSTAIN
                      [ ]             [ ]            [ ]
<PAGE>

3. To approve the Company's 1997 Employee  Stock Purchase Plan covering  400,000
shares issuable under the plan.

                      FOR           AGAINST        ABSTAIN
                      [ ]             [ ]            [ ]



4. In their  discretion the  proxyholders  are authorized to transact such other
business  as  properly  may come  before  the  meeting  or any  adjournments  or
postponements  of the meeting.  The Board of  Directors  at present  knows of no
other  business to be  presented  by or on behalf of the Company or the Board of
Directors at the meeting.

     MARK HERE
    FOR ADDRESS    [ ]
    CHANGE AND
    NOTE AT LEFT

Date and sign  exactly as  name(s)  appear(s)  on this  proxy.  If  signing  for
estates,  trusts,  corporations or other  entities,  title or capacity should be
stated. If shares are held jointly, each holder should sign.

Signature: ___________  Date:_________    Signature: ___________  Date:_________





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