ADVANCED POLYMER SYSTEMS INC /DE/
DEFA14A, 1999-04-22
PLASTIC MATERIALS, SYNTH RESINS & NONVULCAN ELASTOMERS
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                         SCHEDULE 14A

             INFORMATION REQUIRED IN PROXY STATEMENT
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                 Advanced Polymer Systems, Inc.
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           [Advanced Polymer Systems, Inc. logo]

                   123 Saginaw Drive
                 Redwood City, CA 94063

                      NEWS RELEASE
                      ------------

Contacts:
LAUREN FELICE                               GORDON SANGSTER
Investor Relations                               Controller
Ruder-Finn                                   (650) 366-2626
(212) 593-6370

        ADVANCED POLYMER SYSTEMS RECEIVES NOTICE FROM 2%
     STOCKHOLDER OF INTENT TO NOMINATE ALTERNATE BOARD SLATE

Redwood City, CA, April 22, 1999 - Advanced Polymer Systems, 
Inc. (Nasdaq: APOS) today announced that it has received a 
notice of intent to submit director nominations at its 1999 
Annual Meeting of Stockholders in opposition to the 
Company's nominees.

The notice was given by Providence Investors, LLC of New 
York, which states that it and Herbert Denton, its president 
and one of its nominees, together own 397,100 shares of the 
Company's common stock (approximately 2% of the 
outstanding).  The notice named seven other nominees and 
their share ownership, as disclosed in the notice, 
represents approximately 0.2% of the outstanding.

The Board of Directors of Advanced Polymer Systems currently 
consists of eight members.  Each member serves for a one-
year term and is not elected by cumulative voting.

The Board of Directors of Advanced Polymer Systems will 
review the notice in due course.  The Company noted that it 
has not yet set a date for its 1999 Annual Meeting of 
stockholders and that its stockholders are not being asked 
at this time to give any proxies or take any other action 
with respect to the meeting.

CERTAIN INFORMATION CONCERNING PARTICIPANTS

The following individuals, all of whom are directors of 
Advanced Polymer Systems, Inc., may be deemed participants 
in the solicitation of proxies on behalf of the Company's 
Board of Directors: John J. Meakem, Jr. (Chairman of the 
Board, Chief Executive Officer and President of the 
Company); Carl Ehmann, M.D., F.A.C.P. (Director of Reckitt & 
Colman, plc.); Jorge Heller, Ph.D. (Professor); Peter 
Riepenhausen (Business Consultant); Toby Rosenblatt 
(President, The Glen Ellen Company; Vice President; Founders 
Investments, Ltd.); Gregory H. Turnbull (Business 
Consultant); Charles Anthony Wainwright (Chairman, McKinney 
& Silver), and; Dennis Winger (Senior Vice President, Chief 
Financial Officer and Treasurer, Perkin-Elmer).

None of the Company's directors beneficially owns more than 
one percent of the Company's common stock, other than Mr. 
Meakem, who beneficially owns 4.4% of the Company's common 
stock (including 654,247 shares subject to stock options 
exercisable within 60 days of April 22, 1999) and Mr. 
Rosenblatt, who beneficially owns 1.3 % of the Company's 
common stock (including 75,000 shares subject to stock 
options exercisable within 60 days of April 22, 1999).  The 
preceding share ownership numbers are as of April 22, 1999.

Advanced Polymer Systems, is a leader in polymer-based 
delivery systems and related technologies used primarily in 
ethical and over-the-counter (OTC) pharmaceuticals and 
personal care products.  The company's Microsponge(R) and 
Polytrap(R) systems, which deliver active ingredients to the 
skin, now play an integral role in almost 100 personal care 
products sold worldwide.  New products and technologies 
under development include site-specific systems for 
delivering oral medications to the lower gastrointestinal 
tract, and bioerodible microspheres and polymers for oral or 
implantable drug delivery.



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