SOMATOGEN INC
10-K/A, 1996-11-26
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE 1>
SOMATOGEN, INC.
_____________________________________________________________________________

                  SECURITIES AND EXCHANGE COMMISSION
                       Washington, D.C. 20549

                              FORM 10-K/A

     /X/   ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF
                 THE SECURITIES EXCHANGE ACT OF 1934

               For the fiscal year ended June 30, 1996  
                    Commission file number 0-19423

                                 OR

     / /  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF 
                  THE SECURITIES EXCHANGE ACT OF 1934
        For the transition period from __________ to____________

                             Somatogen, Inc.
           (Exact name of registrant as specified in its charter)

                 Delaware                           84-0991858
        (State or other jurisdiction of          (I.R.S. Employer
         incorporation or organization)          Identification No.)

         2545 Central Ave., Boulder, CO                 80301
   (Address of principal executive offices)           (Zip Code)

   Registrant's telephone number, including area code (303) 440-9988

      Securities registered pursuant to Section 12(g) of the Act:

                          Common Stock $.001 par value
                                (Title of Class)

     Indicate by check mark whether the registrant (1) has filed all 
reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such 
shorter period that the registrant was required to file such 
reports), and (2) has been subject to such filing requirements 
for the past 90 days. Yes /X/  No / /
















<PAGE>  2
SOMATOGEN, INC.


     Indicate by checkmark if disclosure of delinquent filers pursuant
to Item 405 of Regulation S-K is not contained herein, and will not 
be contained, to the best of registrant's knowledge, in definitive 
proxy or information statements incorporated by reference in Part 
III of this form 10-K or any amendment to this Form 10-K. [X]

     The approximate aggregate market value of voting stock held by 
nonaffiliates of the registrant is $188,035,287 as of November 21,
1996.*

                              20,713,024
(Number of shares of Common Stock outstanding as of November 21, 1996)


*Excludes 3,681,197 shares of Common Stock held by Directors and 
Officers and Stockholders whose beneficial ownership exceeds ten 
percent of the shares outstanding at November 21, 1996.  Exclusion of 
shares held by any person should not be construed to indicate that 
such person possesses the power, direct or indirect, to direct or 
cause the direction of the management or policies of the registrant, 
or that such person is controlled by or under common control with 
the registrant.


































<PAGE>  3
SOMATOGEN, INC.

PART IV

Item 14.  Exhibits, Financial Statement Schedules and Reports on Form 
- -------   8-K

(a-1) Financial Statements

The following consolidated financial statements of the registrant were 
filed as Appendix F to the Company's Annual Report on Form 10-K for
the year ended June 30, 1996 as originally filed with the Commission on 
September 5, 1996 and incorporated herein by reference thereto:

                                                              Page
Report of Price Waterhouse LLP, Independent Accountants        55

Report of Ernst & Young LLP, Independent Auditors              56

Consolidated Balance Sheet at June 30, 1996 and 1995           57

Consolidated Statement of Operations for each of the three
years in the period ended June 30, 1996 and for the period 
from July 10,1985 (inception) to June 30, 1996                 59

Consolidated Statement of Stockholders' Equity for the period
from July 10, 1985 (inception) to June 30, 1996                61

Consolidated Statement of Cash Flows for each of the three
years in the period ended June 30, 1996 and for the period 
from July 10, 1985 (inception) to June 30, 1996                64

Notes to Consolidated Financial Statements                     67

(a-2) The exhibits to the Annual Report on Form 10-K for the year
ended June 30, 1996 as originally filed with the Commission on 
September 5, 1996 and incorporated herein by reference thereto are 
listed under item 14(c) below.

The following management compensatory plans and arrangements were 
filed as required as exhibits to the Annual Report on Form 
10-K for the year ended June 30, 1996 as originally filed with the 
Commission on September 5, 1996 and incorporated herein by reference 
thereto pursuant to Item 14(c):















<PAGE 4>
SOMATOGEN, INC.


Exhibit
Number  Description
- ------  -----------------
10.2    Registrant's Stock Option Plan as amended (the "Plan"). (1)
10.3    Form of Incentive Stock Option under the Plan. (2)
10.4    Form of Nonstatutory Stock Option under the Plan. (2)
10.25   Registrant's Employee Stock Purchase Plan and related offering
        document. (2)
10.40   Non-Employee Director Stock Option Plan. (3)
10.63   Consultants Stock Option Plan. (4)
10.69   Amendment to the Somatogen, Inc. Amended and Restated Stock
        Option Plan. (5)

(1)  Previously filed with the Commission as an exhibit to the 
     Company's Registration Statement on Form S-1 (File No. 33-48789) 
     and incorporated by reference thereto.

(2)  Previously filed with the Commission as an exhibit to the 
     Company's Registration Statement on Form S-1 (File No. 33-41229) 
     and incorporated by reference thereto.

(3)  Previously filed with the Commission as an exhibit to the
     Company's Annual Report on Form 10-K for the year ended June 30, 
     1993 and incorporated herein by reference thereto.

(4)  Previously filed with the Commission as an exhibit to the 
     Company's Annual Report on Form 10-K for the year ended June 30,
     1995 and incorporated herein by reference thereto.

(5)  Previously filed as an exhibit to the Company's Annual Report on
     Form 10-K for the year ended June 30, 1996 as originally filed 
     with the Commission on September 5, 1996 and incorporated herein 
     by reference thereto.

(b)  Reports on Form 8-K

     The registrant did not file any Reports on Form 8-K during the 
     last quarter of fiscal 1996.

(c)  Exhibits
















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SOMATOGEN, INC.

Exhibit 
Numbers   Description
- -------   -----------
  3.1     Amended and Restated Certificate of Incorporation.(1)
  3.3     Bylaws.(1)
  4.1     Reference is made to Exhibits 3.1 and 3.3.(1)
  4.2     Amended and Restated Registration Agreement between the 
          Registrant and the parties named therein, dated as of 
          March 28, 1990, as amended.(1)
  4.3     Reference is made to Exhibit 10.8.(1)
  4.4     Amendment to the Amended and Restated Registration Agreement, 
          dated as of   June 14, 1991, between the Registrant and the 
          parties named therein.(1)
  4.5     Specimen Common Stock certificate.(1)
 10.1     Form of Indemnification Agreement entered into between the 
          Registrant and its directors and officers with related 
          schedule.(2)
 10.2     Registrant's Stock Option Plan as amended (the "Plan").(2)
 10.3     Form of Incentive Stock Option under the Plan.(1)
 10.4     Form of Nonstatutory Stock Option under the Plan.(1)
 10.6     Purchase Agreement between the Registrant and parties named 
          therein, dated as of October 28, 1988.(1)
 10.7     Series B Preferred Stock Purchase Agreement between the 
          Registrant and the parties named therein, dated as of 
          March 28, 1990.(1)
 10.8     Amendment to Series B Preferred Stock Purchase Agreement, 
          dated as of February 22, 1991, between the Registrant and the 
          parties named therein.(1)
 10.9     Amendment to Preferred  Stock Purchase Agreements, dated as 
          of June 14, 1991, between the Registrant and the parties 
          named therein.(1)
 10.19    Lease Agreement between the Registrant and 2545 Central 
          Avenue Partnership ("Central"), dated as of April 13, 1990, 
          as amended.(2)
 10.20    Lease Agreement between the Registrant and Central, dated as 
          of September 21, 1990.(1)
 10.21    Master Lease and Warrant Agreement between the Registrant and 
          Pacific, as the assignee of Equitec, dated as of March 31, 
          1989.(1)
 10.22    Master Lease and Warrant Agreement between the Registrant and 
          Pacific, dated as of May 2, 1990.(1)
 10.23    Master Lease Agreement between the Registrant and Dominion, 
          dated as of June 29, 1990.(1)
 10.25    Registrant's Employee Stock Purchase Plan and related 
          offering document.(1)












<PAGE 6>
SOMATOGEN, INC.

 10.26    Master Lease Agreement between the Registrant and General 
          Electric Capital Corporation, dated as of March 19, 1992, and 
          accompanying Letter of Credit, as amended, dated as of 
          March 30, 1992, and Promissory Note, Master Security 
          Agreement, and Cross Collateral Agreement, dated as of 
          May 22, 1992.(2)
 10.27    Lease/Option Agreement between the Registrant and the parties 
          named therein, dated as of November 26, 1991, as amended 
          (with certain confidential information in brackets  
          deleted).(2)
 10.28    Purchase Agreement between the Registrant and the parties 
          named therein, dated as of November 26, 1991, as amended 
          (with certain confidential information in brackets 
          deleted).(2)
 10.29    Engineering, Procurement and Validation Service Agreement for 
          Commercial Manufacturing Facility No. 1 between the 
          Registrant and Fluor Daniel, Inc., dated as of April 1, 1992 
          (with certain confidential information in brackets 
          deleted).(2)
 10.30    Engineering, Procurement and Validation Services Agreement 
          for Commercial Manufacturing Facility No. 2 between the 
          Registrant and Fluor Daniel, Inc., dated as of April 1, 1992 
          (with certain confidential information in brackets 
          deleted).(2)
 10.31    Form of warrant with related schedule.(2)
 10.33    Letter agreement dated July 9, 1992 between the Registrant 
          and General Electric Capital Corporation, amending the Master
          Lease Agreement between the Registrant and General Electric 
          Capital Corporation, dated as of March 19, 1992.(2)
 10.34    Lease Agreement between the Registrant and Central, dated as 
          of November 25, 1991.(3)
 10.35    Deed of Trust Note to Flatiron Industrial Park Co. and 
          related Warranty Deed dated September 2, 1992.(3)
 10.36    Water and Wastewater Service Agreement between the City of 
          Boulder and the Company dated as of September 28, 1992.(4)
 10.38    Construction Management Services Agreement for Commercial 
          Manufacturing Facility No. 1 between the Company and Fluor 
          Daniel, Inc., dated as of August 1, 1992 (with certain 
          confidential information deleted) and related letter 
          agreement dated December 1, 1992 (with certain confidential 
          information deleted).(5)
 10.39    Letter agreement dated October 9, 1992 between the Company 
          and Comdisco Electronics Group regarding lease financing 
          commitment.(5)













<PAGE 7>
SOMATOGEN, INC.

 10.40    Non-Employee Director Stock Option Plan.(6)
 10.41    Master lease agreement dated April 28, 1993 between 
          Registrant and BancBoston. (6)
 10.42    Amendment to the Engineering Procurement and Validation 
          Services Agreement for Commercial Manufacturing Facility 
          No.1, between the Company and Fluor Daniel, Inc., dated as of 
          April 1, 1994 (with certain confidential information in 
          brackets deleted). (7)
 10.43    Amendment to the Construction Management Services Agreement 
          for Commercial Manufacturing Facility No. 1 between the 
          Company and Fluor Daniel, Inc., dated as of April 1, 1994 
          (with certain confidential information in brackets 
          deleted).(7)
 10.44    Agreement dated June 24, 1994, among Somatogen, Inc., Eli 
          Lilly and Company, and Lilly Industries Limited (with certain
          confidential information in brackets deleted). (8)
 10.45    Amendment dated June 24, 1994, among Somatogen, Inc., Eli 
          Lilly and Company and Lilly Industries Limited. (8)
 10.46    Stock Purchase Agreement between Somatogen, Inc., Eli Lilly 
          and Company and Lilly Industries Limited. (8)
 10.47    Form of Severance Agreement entered into between the 
          Registrant and certain of its Executive Officers with Related 
          Schedule. (8)
 10.48    Key Employee Agreement for Andre de Bruin, dated July 13, 
          1994. (10)
 10.49    Letter of Employment for J. W. Freytag, dated September 28, 
          1994. (10)
 10.50    Letter of Employment for Robert F. Caspari, dated October 14,
          1994. (10)
 10.51    Letter of Employment Richard J. Gorczynski, dated 
          November 14, 1994. (10)
 10.52    Promissory Note of J. William Freytag for the benefit of the 
          Registrant, dated November 21, 1994. (10)
 10.53    Promissory Note of Robert F. Caspari for the benefit of the 
          Registrant dated December 14, 1994. (10)
 10.54    Consulting Agreement for Charles H. Scoggin, dated 
          January 18, 1995. (10)
 10.55    Lease Agreement dated February 14, 1995 with Central for
          portion of 2545 Central Avenue, Boulder, Colorado. (11)
 10.56    Lease Agreement dated February 14, 1995 with Central 
          for 2590 Central Avenue, Boulder, Colorado. (11)
 10.57    Lease Agreement dated February 14, 1995 with Central 
          for 5797 Central Avenue, Boulder, 
          Colorado. (11)













<PAGE 8>
SOMATOGEN, INC.


 10.58    Lease Renewal Amendment dated December 29, 1994 to the Master
          Lease Agreement with General Electric Capital Corporation 
          dated March 19, 1992. (11)
 10.59    Lease Renewal Contract dated December 29, 1994 with Ellco 
          Leasing Corporation. (11)
 10.60    Exclusive Agency Agreement dated March 30, 1995 with  
          Binswanger Chesterton. (11)
 10.61    Promissory Note of Richard Gorczynski for the benefit of 
          the Registrant dated July 13, 1995. (12)
 10.62    Consulting Agreement with Ralph Snyderman, M.D., dated 
          October 24, 1994. (12)
 10.63    Consultants Stock Option Plan. (12)
 10.64    Stock Purchase Agreement between Somatogen, Inc. and Eli 
          Lilly and Company, dated as of September 18, 1995. (13)
 10.65    Amendment No. 1 to the Stock Purchase Agreement between 
          Somatogen, Inc. and Eli Lilly and Company dated June 29, 
          1994. (13)
 10.66    Amendment No. 3 to the Agreement between Somatogen, Inc. 
          and Eli Lilly and Company dated June 24, 1994, and 
          subsequently amended on June 24, 1994 and May 4, 1995 (with 
          certain confidential information in brackets deleted). (13)
 10.67    Promissory Note of Fiona Wood for the benefit of the 
          Registrant dated July 30, 1996.  (14)
 10.68    Amendment dated July 1, 1996 to Exclusive Agency Agreement 
          with Binswanger Chesterton.  (15)
 10.69    Amendment to the Somatogen, Inc. Amended and Restated Stock 
          Option Plan.  (16)
 16.1     Letter Re: Change in Certifying Accountant. (9)
 23.1     Consent of Price Waterhouse LLP, Independent Accountants. 
          (17)
 23.2     Consent of Ernst & Young LLP, Independent Auditors. (17)
 24.1     Power of Attorney.  Reference is made to page 33 of the
          Company's Annual Report on Form 10-K for the year ended 
          June 30, 1996 as originally filed with the Commission 
          September 5, 1996 and incorporated herein by reference 
          thereto.




















<PAGE 9>
SOMATOGEN, INC.



(1)  Previously filed with the Commission as an exhibit to the 
     Company's Registration Statement on Form S-1 (File No. 33-41229)
     and incorporated herein by reference thereto.

(2)  Previously filed with the Commission as an exhibit to the 
     Company's Registration Statement on Form S-1 (File No. 33-48789)
     and incorporated herein by reference thereto.

(3)  Previously filed with the Commission as an exhibit to the 
     Company's Annual Report on Form 10-K for the year ended June 30,
     1992 and incorporated herein by reference thereto.

(4)  Previously filed as an exhibit to the Company's Quarterly Report
     on Form 10-Q for the quarter ended September 30, 1992 and 
     incorporated herein by reference thereto.

(5)  Previously filed as an exhibit to the Company's Quarterly Report
     on Form 10-Q for the quarter ended December 31, 1992 and 
     incorporated herein by reference thereto.

(6)  Previously filed with the Commission as an exhibit to the 
     Company's Annual Report on Form 10-K for the year ended June 30,
     1993 and incorporated herein by reference thereto.

(7)  Previously filed as an exhibit to the Company's Quarterly Report
     on Form 10-Q for the quarter ended March 31, 1994 and 
     incorporated herein by reference thereto.

(8)  Previously filed as an exhibit to the Company's Annual Report on 
     Form 10-K for the year ended June 30, 1994 and incorporated herein
     by reference thereto.

(9)  Previously filed as an exhibit to the Company's Form 8-K filed on
     August 24, 1994 and incorporated herein by reference thereto.

(10) Previously filed as an exhibit to the Company's Quarterly Report 
     on Form 10-Q for the quarter ended December 31, 1994 and 
     incorporated herein by reference thereto.

(11) Previously filed as an exhibit to the Company's Quarterly Report
     on Form 10-Q for the quarter ended March 31, 1995 and 
     incorporated herein by reference thereto.













<PAGE 10>
SOMATOGEN, INC.



(12) Previously filed as an exhibit to the Company's Annual Report on 
     Form 10-K for the year ended June 30, 1995 and incorporated herein
     by reference thereto.

(13) Previously filed with the Commission as an exhibit to Amendment 
     No. 1 to Schedule 13D filed by Eli Lilly and Company (File No.
     5-42128) on November 9, 1995 and incorporated herein by reference 
     thereto.

(14) Previously filed with the Commission as exhibit 10.64 to the 
     Company's Annual Report on Form 10-K for the year ended June 30, 
     1996 and incorporated herein by reference thereto.

(15) Previously filed with the Commission as exhibit 10.65 to the 
     Company's Annual Report on Form 10-K for the year ended June 30, 
     1996 and incorporated herein by reference thereto.

(16) Previously filed with the Commission as an exhibit to the 
     Company's S-8 Registration Statement on November 7, 1996 and 
     incorporated herein by reference thereto.

(17) Previously filed as an exhibit to the Company's Annual Report on 
     Form 10-K for the year ended June 30, 1996 as originally filed 
     with the Commission on September 5, 1996 and incorporated herein 
     by reference thereto.






























<PAGE 11>
SOMATOGEN, INC.


SIGNATURES

     Pursuant to the requirements of Section 13 or 15(d) of the 
Securities Exchange Act of 1934, the Registrant has duly caused this 
Form 10-K/A to be signed on its behalf by the undersigned, thereunto 
duly authorized on the 26th day of November 1996.

                                          SOMATOGEN, INC.


                                      By: Timothy D. Hoogheem
                                        ----------------------
                                  Senior Vice President of Finance
                                and Administration, CFO and Treasurer
                                    (Principal financial officer)






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