SOMATOGEN INC
10-Q, 1997-10-28
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                   SECURITIES AND EXCHANGE COMMISSION
                      Washington, D.C. 20549

                            Form 10-Q

                            (Mark one)

   X Quarterly report pursuant to Section 13 or 15(d) of the Securities Exchange
  Act of 1934. For the quarterly period ended September 30,
         1997.

   --  Transition  report  pursuant  to  Section  13 or 15(d) of the  Securities
  Exchange Act of 1934. For the transition period from _______ to _______.

                        Commission File Number
                               0-19423

                           Somatogen, Inc.
          (Exact name of registrant as specified in its charter)


       Delaware                                        84-0991858
(State or other jurisdiction of                     (I.R.S. Employer
 incorporation or organization)                     Identification No.)

2545 Central Ave., Suite FD 1, Boulder, CO             80301-2857
  (Address of principal executive offices)             (Zip Code)

      Registrant's telephone number, including area code: (303) 440-9988

          Securities registered pursuant to Section 12(g) of the Act:

                       Common Stock $.001 par value
                             (Title of Class)

         Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes X  No __

         Indicate  the  number of  shares  outstanding  of each of the  issuer's
classes of common stock, as of the latest practicable date.

Common Stock $.001 par value                               20,873,220
         Class                                  Outstanding at October 22, 1997

There are a total of 11 pages included in this document.


Somatogen,  Inc., the Somatogen logo and Optro are tradenames  and/or trademarks
of the Company.  All other brand names or trademarks appearing in this Form 10-Q
are the property of their respective holders.


<PAGE> 2

                              SOMATOGEN, INC.
                                    INDEX







PART I.  FINANCIAL INFORMATION                                        PAGE NO.

  Consolidated Balance Sheet -
         September 30, 1997 and June 30, 1997                             3

  Consolidated Statement of Operations-
         for the three-month periods ended September 30, 1997
         and 1996 and the period from July 10, 1985 (inception) to
         September 30, 1997                                               4

  Consolidated Statement of Cash Flows -
         for the three-month periods ended September 30, 1997 and
         1996 and the period from July 10, 1985 (inception) to
         September 30, 1997                                               5

  Notes to Consolidated Financial Statements                              6

  Management's Discussion and Analysis of Financial Condition
         and Results of Operations                                       7-9

PART II. OTHER INFORMATION                                               10

SIGNATURES                                                               11





<PAGE> 3

                                SOMATOGEN, INC.
                     (A Corporation in the Development Stage)
                          CONSOLIDATED BALANCE SHEET
               (In thousands, except share and per share amounts)

                                     ASSETS
 <TABLE>
<CAPTION>
                                                                   September 30,         June 30,
                                                                        1997                1997
                                                                    ------------          -------
                                                                     (unaudited)
<S>                                                                 <C>                   <C>

Current assets:
     Cash and cash equivalents                                       $    13,400        $    24,868
     Short-term investments                                               26,982             19,158
     Other receivables                                                       530                483
     Prepaid expenses and other current assets                               513                382
                                                                     -----------        -----------
         Total current assets                                             41,425             44,891

Property and equipment, at cost, net of
       accumulated depreciation and amortization                           3,706              3,842
Assets held for sale                                                       5,787              5,942
Other assets, net                                                          1,368              1,356
                                                                     -----------        -----------
                                                                     $    52,286        $    56,031
                                                                     ===========        ===========

                      LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
     Accounts payable                                                $     1,300        $     1,363
     Accrued payroll                                                         761                543
     Other accrued liabilities                                               563                527
                                                                     -----------        -----------
        Total current liabilities                                          2,624              2,433
                                                                     -----------        -----------
Commitments and contingencies
Stockholders' equity:
     Preferred stock, $.001 par value, 10,000,000 shares
         authorized at September 30, 1997,
         no shares issued or outstanding                                    --                 --
     Common stock, $.001 par value; 35,000,000 shares
         authorized, 20,870,746 and 20,865,362 shares
         issued and outstanding at September 30, 1997 and
         June 30, 1997, respectively                                          21                 21
     Additional paid-in capital                                          205,662            205,652
     Deficit accumulated during the development stage                   (155,862)          (151,888)
     Deferred compensation related to grant of options                      (159)              (187)
                                                                     -----------        -----------
         Total stockholders' equity                                       49,662             53,598
                                                                     -----------        -----------
                                                                     $    52,286        $    56,031
                                                                     ===========        ===========

</TABLE>


                  See accompanying notes to consolidated financial statements.




<PAGE> 4


                                          SOMATOGEN, INC.
                            (A Corporation in the Development Stage)
                              CONSOLIDATED STATEMENT OF OPERATIONS
                        (In thousands, except share and per share amounts)
                                            (Unaudited)
<TABLE>
<CAPTION>

                                                                                                    Period from
                                                            Three-months ended                     July 10, 1985
                                                               September 30,                      (inception) to
                                                          1997                1996              September 30, 1997
                                                          ----                ----              ------------------
<S>                                                  <C>                <C>                     <C>

Revenue:
   Technology disclosure and license fees           $         --        $         --             $       4,904
   Research and development grants
       and contracts                                          --                  --                     1,684
                                                    ------------        ------------             -------------
         Total revenue                                        --                  --                     6,588
                                                    ------------        ------------             -------------
Operating expense:
   Research and development                                3,750               4,881                   125,081
   Reimbursements from Lilly                                  --              (1,669)                  (15,577)
   Reimbursements to Lilly                                    --                 840                     4,483
                                                     -----------        ------------             -------------
   Research and development, net                           3,750               4,052                   113,987
   General, administrative and marketing                     823               1,010                    32,195
   Writedown of manufacturing
       facility assets                                        --                  --                    29,194
                                                     -----------        ------------             -------------
         Total operating expense                           4,573               5,062                   175,376
                                                     -----------        ------------             -------------
   Operating loss                                         (4,573)             (5,062)                 (168,788)

   Interest and other income, net                            599                 685                    17,844
                                                     -----------        ------------             -------------

   Loss from continuing operations                        (3,974)             (4,377)                 (150,944)

Discontinued operations:
   Loss from operations of subsidiary                         --                  --                    (1,225)
   Gain on sale of subsidiary                                 --                  --                       300
                                                    ------------         -----------             -------------
   Net loss                                         $     (3,974)       $     (4,377)            $    (151,869)
                                                    ============         ===========             =============

   Net loss per share                               $      (0.19)       $      (0.21)
                                                    ============        ============
   Shares used in calculating
       per share data                                 20,871,000          20,703,000
                                                    ============        ============
</TABLE>

                 See accompanying notes to consolidated financial statements.



<PAGE> 5

                                           SOMATOGEN, INC.
                                (A Corporation in the Development Stage)
                                  CONSOLIDATED STATEMENT OF CASH FLOWS
                                      (In thousands - unaudited)

<TABLE>
<CAPTION>
                                                                                                      Period from
                                                                         Three-months ended          July 10, 1985
                                                                            September 30,           (inception) to
                                                                         1997           1996       September 30, 1997
                                                                         ----           ----       ------------------
<S>                                                               <C>             <C>              <C>

Cash flows provided by (used in) operating activities:
     Net loss                                                     $    (3,974)    $    (4,377)      $   (151,869)
     Adjustments to reconcile net loss to net cash
         used in operating activities:
         Depreciation and amortization                                    365             400             16,817
         Writedown of manufacturing facility assets                        --              --             29,194
         Other, net                                                        (1)             30              1,212
     Changes in assets and liabilities:
         Receivables                                                      (47)            459               (368)
         Prepaid expenses and other current assets                       (131)            151               (488)
         Accounts payable and accrued liabilities                         191            (466)             2,775
         Other, net                                                        --              --                335
                                                                  -----------     -----------       ------------
           Net cash used in operating activities                       (3,597)         (3,803)          (102,392)
                                                                  -----------     -----------       ------------

Cash flows provided by (used in) investing activities:
     Purchase of short-term investments                               (15,613)         (5,246)          (324,292)
     Proceeds from sale of short-term investments                       7,789          13,479            297,310
     Purchases of property and equipment                                 (154)           (272)           (23,665)
     Proceeds from sale of property and equipment                         145             102              3,455
     Additions to construction-in-progress                                 --              --            (18,956)
     Other, net                                                           (48)            (61)            (9,336)
                                                                  -----------     -----------       ------------
         Net cash provided by (used in) investing activities           (7,881)          8,002            (75,484)
                                                                  -----------     -----------       ------------
Cash flows provided by (used in) financing activities:
     Payments of capital lease obligations and long-
         term debt                                                         --             (80)           (10,467)
     Net proceeds from issuance of stock and warrants                      10              93            198,224
     Other                                                                 --              --              3,519
                                                                  -----------     -----------       ------------
     Net cash provided by financing activities                             10              13            191,276
                                                                  -----------     -----------       ------------
Net increase (decrease) in cash and cash equivalents                  (11,468)          4,212             13,400
Cash and cash equivalents at beginning of period                       24,868          29,541                 --
                                                                  -----------     -----------       ------------
Cash and cash equivalents at end of period                        $    13,400      $   33,753       $     13,400
                                                                  ===========     ===========       ============
Supplemental disclosures of cash flow information:
     Cash paid for interest                                       $         3      $        7       $      2,402
     Capital lease obligations incurred for purchase
         of property and equipment                                         --              --              5,318
     Equipment deposits transferred to net
         property, plant and equipment                                     --              --              3,423
     Net property, plant and equipment transferred
         to assets held for sale                                           --              --              9,541
</TABLE>

                See accompanying notes to consolidated financial statements.


<PAGE> 6


                                    SOMATOGEN, INC.
                      (A Corporation in the Development Stage)
                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                    September 30, 1997
                                       (Unaudited)


Note 1.  Statement of Accounting Presentation

     In the opinion of the  Company,  the  accompanying  unaudited  consolidated
financial  statements  include  all  adjustments   (consisting  only  of  normal
recurring  accruals)  necessary  to  fairly  state  the  Company's  consolidated
financial  position as of  September  30, 1997 and the  consolidated  results of
operations  and of cash flows for the  three-month  periods ended  September 30,
1997 and 1996,  and for the period from July 10, 1985  (inception)  to September
30, 1997. The accompanying  consolidated  financial statements should be read in
conjunction with the consolidated financial statements included in the Company's
Annual Report on Form 10-K for the year ended June 30, 1997. The information set
forth in the  accompanying  consolidated  balance sheet as of June 30, 1997, has
been  derived  from the  audited  consolidated  balance  sheet  included  in the
Company's Annual Report on Form 10-K for the year ended June 30, 1997.

         Interim results are not  necessarily  indicative of the results for the
full year.


Note 2.  Strategic Alliance and Research and Development Arrangement

     In June 1994,  the Company  entered into a global  strategic  alliance (the
"Alliance")  with Eli Lilly and  Company  ("Lilly")  to  co-develop  Optro,  the
Company's lead development  compound. In March 1997, the Company received notice
of Lilly's decision to discontinue its  co-development of Optro. The termination
was effective  May 20, 1997, at which time all rights to Optro  reverted back to
the Company, except the marketing rights to Optro in Scandinavia which Pharmacia
& Upjohn Inc. received under its 1991 agreement with the Company.  In accordance
with the termination provision of the Alliance,  the Company received a one-time
termination  payment of $6,000,000 in May 1997 and in July 1997, the Company and
Lilly executed a revolving  credit agreement which provides that the Company may
borrow up to $8,000,000 from Lilly.

Note 3.  Net Loss Per Share

     Net loss per share is computed using the weighted  average number of shares
of common stock  outstanding.  Common  equivalent  shares from stock options and
warrants are excluded from the computation as their effect is antidilutive.


<PAGE> 7

                               SOMATOGEN, INC.
                     Management's Discussion and Analysis of
                  Financial Condition and Results of Operations


     Except for the  historical  information  contained  herein,  the  following
discussion   contains   forward-looking   statements   that  involve  risks  and
uncertainties.  The Company's actual results could differ  materially from those
discussed  here.  Factors  that could cause or  contribute  to such  differences
include,  but are not  limited to,  those  discussed  in this  section and those
discussed in the  Company's  Annual  Report on Form 10-K for the year ended June
30, 1997.

     Since 1987,  Somatogen has been a development stage Company and has devoted
substantially  all of its efforts and  resources  to  research  and  development
related to its recombinant hemoglobin technology.  No revenue has been generated
by  Somatogen  to date from  commercial  product  sales,  and such sales are not
expected  to  commence  for  several  years,  if at all.  To  achieve  sustained
profitable  operations,  Somatogen must successfully develop,  obtain regulatory
approval for,  manufacture and market its products.  The time-frame necessary to
achieve market success for any individual  product is long and uncertain.  There
can be no assurance  that the Company will be able to achieve  profitability  at
all or on a sustained basis.

     For the period  from its  inception  to  September  30,  1997,  the Company
incurred a cumulative  net loss of  $151,869,000.  The Company  expects to incur
substantial and increasing  operating losses during the remainder of fiscal 1998
and  for  the  next  several  years  as  the  Company's  products  will  require
significant  additional research and development including extensive preclinical
and  clinical  testing,  before the Company will be able to apply for and obtain
approval from the FDA or corresponding  foreign  authorities for any indication,
if at all. There can be no assurance that the Company's research and development
efforts  will  be  successful,   that  any  of  the  Company's   products  under
development,  including  Optro,  will prove to be safe or  effective in clinical
trials,  that the Company will be able to obtain regulatory approval to sell any
products,  that the products can be  manufactured at an acceptable cost and with
appropriate  quality,  or that  any  products,  if and when  approved,  could be
successfully marketed.

Results of Operations

     Revenue

     The Company did not recognize any revenue for the three-month periods ended
September 30, 1997 or 1996.

     Operating Expenses

     Total operating  expense  decreased by 10% to $4,573,000 during the quarter
ended  September  30,  1997 from  $5,062,000  for the  comparable  period in the
previous fiscal year.

     Net research and  development  expense for the quarter ended  September 30,
1997 decreased by 7% to $3,750,000 from $4,052,000 for the comparable  period in
the previous fiscal year. The decrease in net research and  development  expense
was primarily due to lower personnel and laboratory  supply expenses,  partially
offset  by  an  increase  in  clinical  trial  expenditures  and a  decrease  in
reimbursements from Eli Lilly and Company ("Lilly").

<PAGE> 8

     General,  administrative and marketing expense decreased by 19% to $823,000
for the quarter ended  September  30, 1997 from  $1,010,000  for the  comparable
quarter in the previous  fiscal year.  This  decrease was  primarily a result of
decreases in personnel and consulting expenses.

     Interest and Other Income, Net

     Interest and other income, net decreased by 13% to $599,000 for the quarter
ended September 30, 1997 from $685,000 for the quarter ended September 30, 1996.
This decrease was primarily a result of decreased  average  investment  balances
partially  offset by higher  yields on U.S.  government  securities,  high grade
commercial paper and money market funds held by the Company.

     Net Loss

     The net loss for the quarter ended  September 30, 1997 was  $3,974,000  (or
$0.19 per share) compared to $4,377,000 (or $0.21 per share) for the same period
in fiscal 1997.

Liquidity and Capital Resources

     Somatogen's  operations to date have consumed  substantial amounts of cash.
Negative cash flow from  operations is expected to increase during the remainder
of fiscal 1998 compared to the levels  experienced during the three-month period
ended  September  30, 1997,  and to increase in  subsequent  fiscal years as the
clinical  studies for Optro increase in scope and the  preclinical  and clinical
studies of new products are undertaken. Somatogen will need to raise significant
additional  funds in order to fund the Company's  future  operations and capital
expenditures prior to commercialization  of the Company's products.  The Company
has relied primarily on public and private  offerings of equity and cost sharing
and equity  investments  pursuant  to the Lilly  strategic  alliance to fund its
operations and upon equipment leasing arrangements to finance the acquisition of
capital  equipment  for  the  Company's   laboratory  and  pilot   manufacturing
facilities.

     At September 30, 1997 the Company had cash, cash equivalents and short-term
investments of $40,382,000.  The Company's cash, cash equivalents and short-term
investments  decreased  approximately  $3,644,000 during the three-month  period
ended  September  30, 1997.  This  decrease was primarily a result of the use of
cash for operations.

     In  September  1992,  the  Company  commenced  construction  of a  clinical
manufacturing  facility.  The Company had also  acquired land for, and begun the
design of, a larger  commercial  manufacturing  facility.  In  conjunction  with
entering  into the Lilly  strategic  alliance,  an  evaluation  of the Company's
future manufacturing requirements was completed and construction of the clinical
manufacturing  facility was  discontinued.  During the fourth  quarter of fiscal
1994,  the Company  recognized a  non-recurring  charge,  which was  principally
non-cash,   associated  with  the  writedown  of  its  clinical  and  commercial
manufacturing  assets of  $29,200,000.  The  components  of the charge  included
approximately  $21,000,000 for the clinical manufacturing  facility,  $6,000,000
for related manufacturing  equipment and $2,200,000 for engineering design costs
for the proposed commercial manufacturing facility.


<PAGE> 9



     Land and  building  related to  manufacturing  facilities  and the  related
manufacturing  equipment  aggregating  $5,787,000  are classified in Somatogen's
balance  sheet as assets  held for sale.  During the  three-month  period  ended
September 30, 1997, the Company realized approximately $145,000 in proceeds from
the sale of assets held for sale.  The Company  believes the aggregate  carrying
value of all assets held for sale approximates the assets' net realizable value;
however,  the Company  continues  to monitor  estimated  realizable  values on a
quarterly  basis.  There can be no assurances  that the Company will realize the
aggregate carrying value of assets held for sale. Proceeds from such asset sales
are being used for general corporate purposes.

     The Company  historically has leased a significant portion of the equipment
used in its laboratory and pilot manufacturing  facilities.  As of September 30,
1997,  the  Company  had  aggregate  future   operating  lease   obligations  of
approximately  $2,364,000.  The Company spent  $154,000  during the  three-month
period  ended  September  30,  1997 for the  purchase of capital  equipment  and
leasehold improvements.

     The Company's near-term operating  requirements  include increased research
and development expenditures, including costs related to clinical trials and new
product  development and  manufacturing.  The Company's capital spending program
includes  purchases of  additional  equipment  for its research and  development
laboratories and pilot manufacturing  facility.  In subsequent fiscal years, the
Company's operating requirements are expected to include continuing increases in
research and development funding to cover the costs of expanded  preclinical and
clinical studies, expenditures associated with commercial manufacturing, as well
as general, administrative, marketing and distribution expenses.

     In order to meet its  long-term  financing  requirements,  the  Company may
pursue a number of  financing  alternatives,  including  public  and/or  private
offerings  of  securities  and  strategic  alliances.  The Company is  currently
engaged in preliminary  discussions with potential strategic partners.  However,
there  can be no  assurance  that the  Company  will be able to  enter  into any
strategic  relationships  and/or  raise  additional  financing.  There can be no
assurance that any strategic  relationship which the Company may enter into will
be on terms favorable to the Company,  or that any additional  funding which may
become  available  to the Company will be on  acceptable  terms.  The  Company's
ability to raise  additional  financing may be dependent on many factors  beyond
the Company's  control,  including the state of the capital markets and the rate
of progress of the Company's clinical trials. Any additional  financing that the
Company may be able to obtain could result in  substantial  dilution to existing
stockholders.  If adequate funds are not available, the Company will be required
to significantly curtail operations.  Any such action could impact the Company's
research and  development  programs,  including  the  Company's  clinical  trial
program.  Any of these events could  adversely  affect the Company's  ability to
commercialize its products.

     Cash  requirements  for the  Company  may vary  materially  from  those now
planned due to results of research and development, results of clinical testing,
changes  in focus  and  direction  of the  Company's  research  and  development
programs,  manufacturing processes,  competitive and technological advances, the
FDA  regulatory  process,  changes in the Company's  marketing and  distribution
strategy and other factors.



<PAGE> 10

                           PART II. OTHER INFORMATION


Item 6.  Exhibits and Reports on Form 8-K

         a)  Exhibits

             10.77    CB Commercial Real Estate Group, Inc. Exclusive
                      Right-to-Sell Listing Contract, dated September 17, 1997.
             27.1     Financial Data Schedule (submitted to the SEC only in
                      electronic format)



         b)  Reports on Form 8-K

             None


<PAGE> 11


                               SOMATOGEN, INC.
                                 SIGNATURES


     The  financial  information  furnished  herein  has  not  been  audited  by
independent  auditors;  however,  in the opinion of management  all  adjustments
necessary for a fair  presentation  for the three-month  periods ended September
30, 1997 and 1996, have been included.

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned thereunto duly authorized.

Date:    October 27, 1997          SOMATOGEN, INC.


                                   Andre de Bruin
                                   Chairman of the Board, President
                                   and Chief Executive Officer
                                   (Authorized Signatory)



                                   Timothy D. Hoogheem
                                   Senior Vice President of Finance
                                   and Administration, Chief Financial
                                   Officer, Treasurer and Assistant Secretary
                                   (Principal Financial Officer)



                                   Conrad A. McCarty
                                   Corporate Controller
                                   (Principal Accounting Officer)


<TABLE> <S> <C>

<ARTICLE>     5
<LEGEND> THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
 CONSOLIDATED  BALANCE  SHEET AS OF  SEPTEMBER  30,  1997  AND THE  CONSOLIDATED
 STATEMENT OF  OPERATIONS  FOR THE THREE MONTHS ENDED  SEPTEMBER 30, 1997 AND IS
 QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER>  1,000
       
<S>                                  <C>
<PERIOD-TYPE>                        3-MOS
<FISCAL-YEAR-END>                    JUN-30-1998
<PERIOD-END>                         SEP-30-1997
<CASH>                                    13,400
<SECURITIES>                              26,982
<RECEIVABLES>                                530
<ALLOWANCES>                                   0
<INVENTORY>                                    0
<CURRENT-ASSETS>                          41,425
<PP&E>                                    17,903
<DEPRECIATION>                            14,197
<TOTAL-ASSETS>                            52,286
<CURRENT-LIABILITIES>                      2,624
<BONDS>                                        0
<COMMON>                                      21
                          0
                                    0
<OTHER-SE>                                49,641
<TOTAL-LIABILITY-AND-EQUITY>              52,286
<SALES>                                        0
<TOTAL-REVENUES>                               0
<CGS>                                          0
<TOTAL-COSTS>                                  0
<OTHER-EXPENSES>                           3,750
<LOSS-PROVISION>                               0
<INTEREST-EXPENSE>                             3
<INCOME-PRETAX>                           (3,974)
<INCOME-TAX>                                   0
<INCOME-CONTINUING>                       (3,974)
<DISCONTINUED>                                 0
<EXTRAORDINARY>                                0
<CHANGES>                                      0
<NET-INCOME>                              (3,974)
<EPS-PRIMARY>                              (0.19)
<EPS-DILUTED>                                  0
        

</TABLE>




Compensation  charged by real estate brokers is not set by law. Such charges are
established by each real estate broker.

DIFFERENT  BROKERAGE  RELATIONSHIPS  ARE  AVAILABLE  WHICH INCLUDE BUYER AGENCY,
SELLER AGENCY, SUBAGENCY OR TRANSACTION-BROKER.

                    EXCLUSIVE RIGHT-TO-SELL LISTING CONTRACT
                          (FARM AND RANCH/VACANT LAND)
                                 (SELLER AGENCY)

                                                     Denver, Colorado   9/17/97


SOMATOGEN,  INC.  ("Seller") hereby  irrevocably  appoint(s) CB Commercial  Real
Estate  Group,  Inc.,  1050 - 17th Street,  Suite 800,  Denver,  Colorado  80265
("Broker")  as  Seller's  exclusive  agent for the  purposes and under the terms
specified herein, and the parties agree:

     1.  PURPOSE  OF  AGENCY.  The  purpose of this  agency  contract  ("Listing
Contract")  is to engage the  efforts of Broker to  accomplish  the sale of real
property legally described as:

                          Lot 8 Flatiron Industrial Park 5

also known as 2400 - 55th Street,  Boulder,  Colorado  80301, together  with the
following water rights:  None the following  water stock:  None all well rights,
reservoir or storage rights, if any; all pumping or well equipment, if any, the
following  growing crops: None and all items of personal property to be conveyed
pursuant to Section 8 (collectively, the "Property").

     2.  BROKER'S  SERVICES.  Broker is a limited  agent of the  Seller and will
represent only Seller.
         (a)  Broker  shall  promote the interests of the Seller with the utmost
              good faith, loyalty and fidelity,  including, but not limited to:
              (1) Seeking a price and terms which are  acceptable to the Seller,
              except that Broker shall not be obligated to seek additional  
              offers to purchase the Property while the Property is subject to a
              contract for sale;  

<PAGE> 2

              (2)  Presenting  all offers to and from the Seller in a timely  
              manner regardless of whether the Property is subject to a contract
              for sale;
              (3) Disclosing to the Seller adverse material facts actually known
              by the Broker;
              (4) Counseling the Seller as to any material  benefits or risks of
              a  transaction  actually  known by the Broker;  
              (5)  Advising  the Seller to obtain expert advice as to material  
              matters about which the Broker knows but the specifics of which 
              are beyond the expertise of the Broker;
              (6) Accounting in a timely manner for all money and property
              received; and
              (7) Informing  the  Seller  that such  Seller  may be  vicariously
              liable  for the acts of such  Seller's  agent or any  subagent
              when the  Broker is  acting  within  the  scope of the  agency
              relationship;
         (b)  Broker shall not disclose the  following  information  without the
              informed consent of the Seller:  
              (1) That the Seller is willing to accept less than the asking 
              price for the  Property;  
              (2) What the motivating  factors are for the Seller to sell the  
              Property;
              (3) That the Seller  will agree to  financing  terms  other than 
              those offered;  
              (4) Any material information about the Seller unless the
              disclosure is required by law or failure to disclose such
              information would constitute fraud or dishonest dealing; or
              (5) Any  facts or  suspicions  regarding  circumstances  which may
              psychologically   impact  or  stigmatize   any  real  property
              pursuant to Colorado law.
         (c)  Broker  shall  disclose  to  any  prospective  buyer  all  adverse
              material facts actually known by Broker  including but not limited
              to adverse  material facts pertaining to the title to the Property
              and the physical  condition of the Property,  any material defects
              in the  Property,  and any  environmental  hazards  affecting  the
              Property which are required by law to be disclosed.

     3. SALE.  "Sale of the Property" or "Sale" means the voluntary  transfer or
exchange of any interest in the Property or the voluntary  creation of the right
to acquire any interest in the Property.

     4. EFFECT OF THIS LISTING CONTRACT.  By this appointment,  Seller agrees to
conduct all negotiations  for the Sale of the Property only through Broker,  and
to refer to Broker all inquiries  received in any form from real estate brokers,
salespersons,  perspective  buyers,  tenants or any other source during the time
this Listing  Contract is in effect.  Seller  authorizes  Broker to disclose any
facts  about  the  Property.   In  addition,   Seller  agrees  that  any  Broker
compensation which is conditioned upon the Sale of the Property shall be earned
by Broker as set forth herein  without any discount or allowance for any efforts
made by Seller or by any representative of Seller in connection with the Sale of
the Property.

<PAGE> 3

     5. THE LISTING  PERIOD.  Broker's  authority shall begin September 17, 1997
and shall continue through September 17, 1998 ("Listing Period").

     6.  PRICE AND TERMS.  Price: U.S. $3,500,000.00    Terms:  Cash.  Minimum
amount of earnest money deposit - Acceptable to owner.

     7. DEPOSITS. Broker is authorized to accept earnest money deposits pursuant
to a proposed Sale  contract.  Broker is authorized to deliver the earnest money
deposit to the  closing  agent,  if any,  at or before  the  closing of the Sale
contract.

     8. Intentionally omitted from contract.

     9. TITLE AND  ENCUMBRANCES.  Seller  represents to Broker that title to the
Property is solely in Seller's name.  Seller shall deliver to Broker true copies
of all relevant title materials,  lease(s) and survey(s) in Seller's  possession
and shall disclose to Broker all easements,  liens and encumbrances,  if any, on
the Property of which Seller has knowledge.  Seller authorizes the holder of any
obligation  secured by an  encumbrance on the Property to disclose to Broker the
amount owing on said encumbrance and the terms thereof.

         In case of Sale,  Seller agrees to convey,  by a special Warranty deed,
only that title Seller has in the Property.  All monetary  encumbrances (such as
mortgages,  deeds of trust, liens, financing statements) shall be paid by Seller
and released except as Seller and buyer may otherwise agree.  Existing  monetary
encumbrances  are as follows:  none.  The  Property is subject to the  following
leases and tenancies: none.

     10. EVIDENCE OF TITLE. Seller agrees to furnish buyer, at Seller's expense,
a commitment for, and a policy of, title insurance to the Property  certified to
a current date in the amount specified by any Sale contract.

     11. PRORATIONS.  General taxes for the year of closing,  based on the taxes
for the calendar year  immediately  preceding  closing,  rents,  water and sewer
charges,  owner's association dues and interest on continuing loans(s),  if any,
shall be prorated to date of closing.

     12.  POSSESSION.  Possession of the Property shall be delivered to buyer as
follows: upon delivery of deed, subject to leases and tenancies as described in
Section 9.

     13.  MATERIAL  DEFECTS -- BROKER  DISCLOSURES -- INSPECTION.  Seller agrees
that any defects of a material nature (including, but not limited to, structural
defects;  soil  conditions;  violations  of  health,  zoning or  building  laws;
nonconforming  uses and  zoning  variances)  actually  known by Broker  must be
disclosed by Broker to any prospective  buyer.  Seller agrees that any buyer may
have the Property and inclusions inspected.

<PAGE> 4

     14. COMMISSION TO BROKER.
         (a)  Commission.  In consideration of the services to be performed by 
              Broker, Seller agrees to pay Broker as follows:
              (1) Sale Commission: 6% of the gross sales price in U.S. dollars.
         (b)  When Earned. Such commission shall be earned upon the happening of
              any of the  following:  
              (1) Any Sale of the  Property  within  the Listing Period by
                  Seller, by Broker or by any other person;
              (2) Intentionally omitted from contract.
              (3) Any Sale of the Property within 90 calendar days subsequent to
                  the  expiration of the Listing Period  ("Holdover  Period") to
                  anyone  with  whom  Broker   negotiated  and  whose  name  was
                  submitted,  in writing, to Seller by Broker during the Listing
                  Period (including any extensions thereof).
         (c)  When Applicable and Payable.  The commission obligation shall 
              apply to a Sale made during the  Listing  Period or made during 
              any  extension  of such original or extended term. The commission 
              described in subsection (a)(1) shall be payable at the time of the
              closing of the Sale as contemplated by subsection (b)(1) or
              (b)(3).

     15.   LIMITATION  ON  BROKER'S   COMPENSATION.   Broker  shall  not  accept
compensation  from the buyer, the buyer's agent, or any entity  participating in
or providing services for the Sale without the written consent of Seller.

     16. OTHER BROKERS, ASSISTANCE -- MULTIPLE LISTING SERVICE.
         (a) Broker shall seek  assistance  from and offer  compensation  to the
             following brokers outside of the listing company:
              (1) Intentionally omitted from contract.
              (2) Brokers representing the buyer ("Buyer Agents"), (Buyer Agents
                  representing  the buyer  owe  duties  of  utmost  good  faith,
                  loyalty and fidelity to buyer only.  Seller is not vicariously
                  liable  for the  acts of  Buyer  Agents).  Broker  will  offer
                  compensation  to  Buyer  Agents  as  follows:   50%  of  total
                  commission.
              (3) Brokers assisting the buyer in the transactions but not acting
                  as agents ("Transaction-Brokers").  (Transaction-Brokers  must
                  exercise reasonable skill and care for the parties.  Seller is
                  not vicariously  liable for the acts of  Transaction-Broker).
                  Broker  will  offer  compensation  to   Transaction-Broker  as
                  follows:  50% of total commission.  
          (b)  Broker will not submit the Property to a multiple listing 
               service.

<PAGE> 5

     17. IN-COMPANY DUAL AGENCY AND TRANSACTION-BROKER. If a written Dual Agency
Addendum or  Transaction-Broker  Addendum  is signed by Seller,  Broker may show
Property to buyers represented or assisted by Broker.

     18.  FORFEITURE OF PAYMENTS.  In the event of a forfeiture of payments made
by a buyer,  the sums  received  shall be divided  between  Broker  and  Seller,
one-half thereof to Broker, but not to exceed the commission agreed upon herein,
and the balance to Seller.

     19. COST OF SERVICES; REIMBURSEMENT.  Unless otherwise specified in Section
28,  Broker  shall  bear all  expenses  incurred  by Broker,  if any,  to market
Property and to compensate  cooperating  brokers, if any. Broker will not obtain
or order any other  products or services  unless Seller agrees in writing to pay
for them  promptly  when  due.  Unless  otherwise  agreed,  Broker  shall not be
obligated  to advance  funds for the  benefit  of Seller in order to  complete a
closing (Examples:  surveys, radon tests, soil tests, title reports, engineering
studies).  Seller shall  reimburse  Broker for payments  made by Broker for such
other products or services authorized by Seller.

     20.  MAINTENANCE  OF THE  PROPERTY.  Seller agrees that Broker shall not be
responsible  for  maintenance  of the  Property  nor shall  Broker be liable for
damage of any kind occurring to the Property, unless such damage shall be caused
by the negligence of Broker.

     21. OTHER SELLERS. Seller acknowledges that Broker may have agreements with
other sellers to market and sell their properties.

     22.  NONDISCRIMINATION.  The parties agree not to  discriminate  unlawfully
against any prospective  buyer because of the race,  creed,  color, sex, marital
status, national origin, familial status, physical or mental handicap,  religion
or ancestry of such person.

     23.  RECOMMENDATION  OF LEGAL  COUNSEL.  By signing this  document,  Seller
acknowledges  that Broker has advised  that this  document has  important  legal
consequences  and has  recommended  consultation  with  legal  and tax or  other
counsel, before signing this contract.

     24. ALTERNATIVE DISPUTE RESOLUTION: MEDIATION. If a dispute arises relating
to this  contract,  and is not  resolved,  the parties  involved in such dispute
(Disputants)  shall  first  proceed  in good  faith  to  submit  the  matter  to
mediation.  The Disputants will jointly appoint an acceptable  mediator and will
share equally in the cost of such mediation.  In the event the entire dispute is
not resolved  within  thirty (30)  calendar  days from the date  written  notice
requesting  mediation is sent by one Disputant to the other(s),  the  mediation,
unless otherwise agreed, shall terminate.  This section shall not alter any date
in this contract, unless otherwise agreed.

<PAGE> 6

     25. ATTORNEY FEES. In case of arbitration or litigation  between Seller and
Broker  in their  respective  capacities,  the  parties  agree  that  costs  and
reasonable attorney fees shall be awarded to the prevailing party.

     26.  MODIFICATION OF THIS LISTING CONTRACT.  No subsequent  modification of
any of the  terms of this  Listing  Contract  shall be valid,  binding  upon the
parties, or enforceable unless made in writing and signed by the parties.

     27.  ENTIRE  AGREEMENT.   This  listing  Contract  constitutes  the  entire
agreement  between the parties  relating  to the subject  hereof,  and any prior
agreements  pertaining  thereto,  whether oral or written,  have been merged and
integrated into this Listing Contract.

     28. ADDITIONAL  PROVISIONS:  (The language of these additional  provisions,
Sections  29 and  30,  has  not  been  approved  by  the  Colorado  Real  Estate
Commission.)

     29. If any of the following parties enters into a purchase contract for the
subject  property  within  the  first  45 days of this  Exclusive  Right to Sell
Agreement,  then "No broker fee will be due."  Broker  shall be due one  quarter
(1/4) of the fee stated herein should one of the following  parties enter into a
purchase  contract during the second 45 days and 100% after 90 days of listing.
These parties are:

         1)   Flatiron Park Company or any of its Agents - Larry Frey
         2)   WW Reynolds Company
         3)   Boulder County

     30.  If the  Property  is sold as part of a  contract  to the  sale of 5600
Flatiron  Parkway  ("CMF-1") by Binswanger,  a Broker retained by the Seller for
the purpose of selling CMF-1,  then  Binswanger  shall be entitled to 50% of the
total commission.

     31.  COPIES OF  AGREEMENT.  This  Listing  Contract is executed in multiple
copies and Seller  acknowledges  receipt  of one copy of this  Listing  Contract
signed by Broker.

     32. COUNTERPARTS. If more than one person is named as a Seller herein, this
Listing  Contract  may be  executed by each  Seller  individually  and when each
Seller has executed a copy of this Listing  Contract such copies taken  together
shall be deemed to be a full and complete contract between the parties.

Accepted:  CB Commercial Real Estate Group,  Inc.       Somatogen, Inc.
           --------------------------------------       ---------------
           Broker                                       Seller

By:        Stan S. O'Dell                               Timothy D. Hoogheem
Address:   1050 - 17th Street, Suite 800                2545 Central Avenue
           Denver, Colorado  80265                      Suite FD1
Phone:     (303) 628-7400                               Boulder, Colorado 80301
                                                        (303) 440-9988




<PAGE> 7



                              DUAL AGENCY ADDENDUM
                          (For In-Company Transactions)


1. AMENDMENT TO AGENCY CONTRACT:  This Dual Agency Addendum is part of a Listing
Contract  dated  September 17, 1997 between the broker named below and its sales
agents  ("Broker") and the undersigned Buyer or Seller. If this addendum is used
with a lease or rental transaction,  the word "Seller" shall mean "Landlord" and
the word "Buyer" shall mean "Tenant". This Addendum will control in the event of
any conflict with the contract to which it is attached.

2. LIMITATION ON BROKER'S AGENCY  OBLIGATIONS.  When acting as the agent for one
party (either Buyer or Seller),  Broker has duties and obligations which include
utmost good faith, loyalty and fidelity to that one principal.  If the principal
consents, however, Broker may act as a Dual Agent when both the Seller and Buyer
have an agency  relationship  with the same  real  estate  company  ("In-Company
Transaction").  A Dual  Agent is a broker  engaged  as a limited  agent for both
Seller and Buyer.  Dual agency creates a conflict of interest  because  Broker's
duties and  obligations of  confidentiality,  full disclosure and loyalty to one
party  conflict  with  those same  duties to the other.  Seller and Buyer may be
vicariously liable for acts of a Dual Agent.

     a. If this  addendum  is  signed  by  Seller,  Broker  will act only as the
exclusive agent for Seller when the Property is shown to a prospective buyer who
has a working  relationship with another licensed real estate company,  but will
act only as a Dual Agent in an In-Company Transaction.

     b. If this  addendum  is  signed  by  Buyer,  Broker  will  act only as the
exclusive  agent for Buyer when  showing  properties  that are not  listed  with
Broker, but will act only as a Dual Agent in an In- Company Transaction.

The remaining  provisions of this addendum describe  significant changes to the
obligations of Broker when acting as a Dual Agent in an In-Company Transaction.

3. MATTERS THAT CAN BE DISCLOSED BY A DUAL AGENT. Except as set forth in Section
4, Broker,  when acting as a Dual Agent,  may disclose  any  information  to one
party that Broker gains from the other party if the  information  is relevant to
the transaction or party.

<PAGE> 8

4. MATTERS THAT CANNOT BE  DISCLOSED BY A DUAL AGENT.  Broker,  when acting as a
Dual Agent,  shall not  disclose  the  following  information  without the prior
consent of Seller and Buyer.
     a. That Buyer is willing to pay more than the purchase  price  offered for
the  property;  
     b. That  Seller is willing to accept  less than the asking price for the 
property;  
     c. What the motivating  factors are for any party buying or  selling  the
property;  
     d. That  Seller or Buyer will agree to financing  terms other than those  
offered;  
     e. Any  material  information about the other party unless either:
        (1) the disclosure is required by law,
        (2) the  disclosure  pertains to adverse  material  facts about Buyer's
            financial ability to perform the terms of the transaction,
        (3) the disclosure pertains to Buyer's intent to occupy the property as
            a principal residence, or (4) failure to disclose such information
            would constitute fraud or dishonest dealing.

5.  ADDITIONAL  PROVISIONS.  Notwithstanding  any  provision  contained  in  the
Agreement,  Somatogen  will  not  be  obligated  to  pay  to CB  Commercial  any
commission,  fee or any other  compensation  including,  but not  limited to the
Commission  Fee,  pursuant to the Listing  Contract or  otherwise,  if Somatogen
sells, leases,  conveys, or in any other way transfers the Property to any party
that was introduced to Somatogen through an entity or individual (such entity or
individual,  an "Investment  Bank") that has a written  agreement with Somatogen
which  obligates  Somatogen to pay a fee to such  Investment  Bank in connection
with a transaction involving Somatogen.


Accepted:    Somatogen, Inc..

Seller:   Timothy D. Hoogheem                        Date:   9/17/97


Broker:  CB Commercial Real Estate Group, Inc.

By:  Stan S. O'Dell                                  Date:   9/18/97




<PAGE> 9



                                   ADDENDUM A
                                       TO
                    EXCLUSIVE RIGHT-TO-SELL LISTING CONTRACT
                                      DATED
                               SEPTEMBER 17, 1997
                                     between
                           SOMATOGEN, INC. ("SELLER")
                                       and
                CB COMMERCIAL REAL ESTATE GROUP, INC. ("BROKER")
                            (the "Listing Contract")


     THIS  ADDENDUM  A (this "Addendum")  is  attached  to and made  part of the
above-referenced Listing Contract. In the event of the existence of any conflict
between the terms set forth in the Listing  Contract  and the terms set forth in
this Addendum,  the terms set forth in this Addendum  shall control.  As used in
this Addendum,  the term "Listing  Contract" shall mean the Listing  Contract as
amended and supplemented by this Addendum.

     1. Price and Terms.  The price for the  Property  set forth in Section 6 of
this  Listing  Contract,  and the other terms for the sale of the  Property  set
forth in Sections 6 through 12 of this Listing  Contract,  are provided  only as
guidelines  to be used by Broker  in  presenting  the  Property  to  prospective
purchasers. Seller reserves the right to change such price and any of such terms
at any time and from time to time.  Seller shall have no  obligation to sell the
Property,  or to enter into any contract for the sale of the  Property,  at such
price or upon any of such terms.

     2. Commission Earned Upon Closing. No commission shall be earned by Broker,
and no commission  shall be payable by Seller,  except upon the  consummation of
the closing of the sale by Seller of the Property in  accordance  with the terms
set forth in this Listing  Contract.  No commission  shall be payable under this
Listing  Contract  unless  and until  the  closing  of the sale of the  Property
occurs,  without  regard to the  reason why a closing  failed to occur.  Without
limiting the generality of the foregoing,  no commission shall be payable in the
event that:  (i) Seller fails to acquire the  Property,  (ii) Seller  refuses or
fails to enter into a contract for sale with any  purchaser,  regardless  of the
terms provided in such contract, (iii) Seller fails or refuses to close the sale
of the Property which Seller has contracted to sell,  regardless of whether such
failure constitutes a breach by Seller under such contract,  or (iv) the closing
of a sale of the Property  fails to occur for any other reason,  including  both
reasons  which are in the  control  of Seller and  reasons  which are not in the
control of Seller.

<PAGE> 10

     3.  Determination  of Co-ops:  Indemnity.  Broker shall be responsible  for
determining  whether any other broker, salesman, or agent is entitled to a co-op
commission  or  other  compensation  on any  sale of the  Property  for  which a
commission is payable to Broker under the terms of this Listing Contract. Broker
shall  indemnify,  defend and hold harmless  Seller from and against any and all
claims for co-op commissions or other compensation  payable to any other broker,
salesman or agent as a result of the Property  hereunder;  provided  that Broker
does not hereby  indemnify  Seller against any claims for  commissions, fees, or
other compensation  payable to any other broker, salesman, or agent arising from
the sale of the  Property to the extent such claims are based upon any  specific
agreement or undertaking made by Seller outside of this Listing Agreement.

     4.  As  Is  Sale.  Broker  shall  market  the  Property  "As  Is,"  without
representation or warranty of any kind from Seller as to any matter whatsoever.

     5. Termination. Seller may terminate this Listing Contract at any time, for
any  reason or no reason,  upon 15 days  written  notice to  Broker,  subject to
Section 14(b)(3) of this Listing Contract.

     6. No  Assignment.  Neither  party hereto shall be permitted to assign this
Listing Contract without the prior written consent of the other party hereto.

     7. Governing Law. The validity and effect of this Listing Contract shall be
determined in accordance with the laws of the State of Colorado.

     8. Facsimile.  Facsimile  signatures are acceptable to and binding upon all
parties to this Listing Contract.




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