SOMATOGEN INC
DEF 14A, 1997-09-11
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE> 1

September 14, 1997



DEAR STOCKHOLDER:

You are  cordially  invited  to attend the Annual  Meeting  of  Stockholders  of
Somatogen,  Inc. (the  "Company") to be held on the 28th day of October 1997, at
10:00 A.M. MDT, at the Broker Inn, 555 Thirtieth Street, Boulder, Colorado.

At this year's Annual Meeting,  you will be asked to elect seven  directors,  to
amend the Company's  Non-Employee  Director  Stock Option Plan and to ratify the
appointment of the Company's  independent  accountants for fiscal year 1998. The
accompanying Notice of Meeting and Proxy Statement describe these proposals. The
Board of Directors has approved the proposals  described in the Proxy  Statement
and recommends a vote "FOR" each proposal.

In addition  to the formal  business to be  transacted,  management  will make a
presentation  on  developments  of the past year and  respond  to  comments  and
questions of general interest to stockholders.

It is important  that your shares be represented  and voted,  whether or not you
plan to attend the Annual  Meeting.  Therefore,  please sign,  date and promptly
mail the enclosed proxy in the prepaid envelope provided.

Sincerely,




Andre de Bruin
Chairman of the Board, President
and Chief Executive Officer




<PAGE> 2


NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD ON OCTOBER 28, 1997

TO THE STOCKHOLDERS OF SOMATOGEN, INC.:

NOTICE IS HEREBY GIVEN that the Annual  Meeting of  Stockholders  of  Somatogen,
Inc., a Delaware corporation (the "Company"),  will be held on Tuesday,  October
28, 1997, at 10:00 A.M. MDT, at the Broker Inn, 555 Thirtieth  Street,  Boulder,
Colorado, for the following purposes:
         1.       To elect seven directors to hold office until the next annual
                  meeting of stockholders;
         2.       To approve an amendment to the Company's Non-Employee Director
                  Stock  Option  Plan  ("Directors'   Plan"),  to  increase  the
                  aggregate  number of shares of  Common  Stock  authorized  for
                  issuance  under the  Directors'  Plan by  200,000  shares,  to
                  increase  the   non-discretionary   option  grants  under  the
                  Directors'  Plan,  to  accelerate  the  vesting  of  options
                  granted  under the  Directors'  Plan upon  certain  changes in
                  control  of the  Company,  and  to  incorporate  a  directors'
                  deferred fee option grant feature;
         3.       To ratify the selection of Price Waterhouse LLP as independent
                  accountants of the Company for the fiscal year ending June 30,
                  1998; and
         4.       To transact  such other  business as may properly  come before
                  the meeting or any adjournment or postponement thereof.

The foregoing  items of business are more fully described in the Proxy Statement
accompanying this Notice.

The Board of  Directors  has fixed the close of business on September 3, 1997 as
the record date for the determination of stockholders  entitled to notice of and
to  vote  at  this  Annual  Meeting  and at  any  continuation,  adjournment  or
postponement thereof.

                                             By Order of the Board of Directors


                                             James C.T. Linfield,
                                             Secretary
Boulder, Colorado
September 14, 1997

ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.  WHETHER
OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE,  DATE, SIGN AND RETURN
THE   ENCLOSED   PROXY  AS   PROMPTLY  AS  POSSIBLE  IN  ORDER  TO  ENSURE  YOUR
REPRESENTATION  AT THE MEETING.  A RETURN ENVELOPE IS ENCLOSED FOR THAT PURPOSE.
EVEN IF YOU HAVE  VOTED YOUR  PROXY,  YOU MAY STILL VOTE IN PERSON IF YOU ATTEND
THE MEETING.  PLEASE NOTE, HOWEVER,  THAT IF YOUR SHARES ARE HELD OF RECORD BY A
BROKER,  BANK OR OTHER  NOMINEE AND YOU WISH TO ATTEND AND VOTE AT THE  MEETING,
YOU MUST BRING TO THE MEETING A PROXY ISSUED IN YOUR NAME FROM THE BROKER,  BANK
OR OTHER NOMINEE. ADDITIONALLY, IN ORDER TO VOTE AT THE MEETING, YOU MUST OBTAIN
FROM THE RECORD HOLDER A PROXY ISSUED IN YOUR NAME.


<PAGE> 3


                                 SOMATOGEN, INC.
                         2545 Central Avenue, Suite FD1
                          Boulder, Colorado 80301-2857

                                 PROXY STATEMENT

                 INFORMATION CONCERNING SOLICITATION AND VOTING

General

The enclosed  proxy is solicited on behalf of the Board of Directors (the "Board
of Directors" or the "Board") of Somatogen,  Inc., a Delaware  corporation  (the
"Company"), for use at the Annual Meeting of Stockholders to be held on Tuesday,
October  28,  1997,  at  10:00  A.M.  MDT,  (the  "Annual  Meeting"),  or at any
continuation,  adjournment or postponement  thereof,  for the purposes set forth
herein and in the accompanying Notice of Annual Meeting. The Annual Meeting will
be held at the Broker Inn, 555 Thirtieth Street, Boulder, Colorado.

Solicitation

The Company  will bear the entire  cost of  solicitation  of proxies,  including
preparation,  assembly  and mailing of this proxy  statement,  the proxy and any
additional  information  furnished  to  stockholders.   Copies  of  solicitation
materials  will  be  furnished  to  banks,  brokerage  houses,  fiduciaries  and
custodians  holding shares of the Company's Common Stock (the "Common Stock") in
their names which are  beneficially  owned by others to forward the solicitation
materials  to  such  beneficial   owners.  The  Company  may  reimburse  persons
representing  beneficial  owners for their costs of forwarding the  solicitation
material to such beneficial owners. Original solicitation of proxies by mail may
be supplemented by telephone,  telegram,  or personal solicitation by directors,
officers  or other  regular  employees  of the  Company,  or,  at the  Company's
request,  Beacon Hill Partners,  Inc. No additional compensation will be paid to
directors,  officers or other regular  employees for such  services,  but Beacon
Hill  Partners,  Inc.  will be paid its  customary  fee,  estimated  to be about
$3,000, if it renders solicitation services.

This  proxy  statement  and  accompanying  proxy card will be mailed on or about
September 14, 1997, to all stockholders entitled to vote at the Annual Meeting.

Voting Rights and Outstanding Shares

Only  holders of record of Common Stock at the close of business on September 3,
1997 will be  entitled  to notice of and to vote at the Annual  Meeting.  At the
close of business on  September 3, 1997 there were  outstanding  and entitled to
vote  20,870,621  shares of Common Stock.  Each holder of record on such date is
entitled  to one vote for each share held on all matters to be voted upon at the
Annual Meeting.

All votes will be  tabulated  by the  inspector  of election  appointed  for the
meeting,   who  will  separately   tabulate   affirmative  and  negative  votes,
abstentions  and  broker  non-votes.  Abstentions  will be counted  towards  the
tabulation  of votes cast on proposals  presented to the  stockholders  and will
have the same effect as negative votes.  Broker  non-votes are counted towards a
quorum, but are not counted for any purpose in determining  whether a matter has
been approved.


<PAGE> 4


Revocability of Proxies

Any person giving a proxy pursuant to this  solicitation has the power to revoke
it at any  time  before  it is  voted.  It may be  revoked  by  filing  with the
Secretary of the Company at the Company's principal executive office, Somatogen,
Inc., 2545 Central Avenue, Suite FD1, Boulder,  Colorado  80301-2857,  a written
notice of revocation or a duly executed proxy bearing a later date, or it may be
revoked by attending the meeting and voting in person. Attendance at the meeting
will not, by itself, revoke a proxy.

Stockholder Proposals

Proposals of  stockholders  that are  intended to be presented at the  Company's
1998 Annual Meeting of Stockholders (the "1998 Annual Meeting") must be received
by the  Company no later than May 14,  1998 in order to be included in the proxy
statement and proxy relating to the 1998 Annual Meeting.

                                   PROPOSAL 1

                              ELECTION OF DIRECTORS

The Company's Restated Certificate of Incorporation and By-laws provide that the
authorized number of directors shall be determined by resolution of the Board of
Directors.  The  resolution  currently  in effect  provides for a Board of seven
members.

Vacancies on the Board may be filled by a majority of the  remaining  directors,
unless such directors  determine to submit such matter for a stockholder vote. A
director elected by the Board to fill a vacancy  (including a vacancy created by
an increase in size of the Board of  Directors)  will serve for the remainder of
the full term of the  director for which the vacancy was created or occurred and
until such director's successor shall have been elected and qualified.

There are seven nominees for the seven Board positions  authorized by resolution
of the  Board of  Directors.  If  elected  at the  Annual  Meeting,  each of the
nominees  would  serve  until  the 1998  Annual  Meeting  and  until  his or her
successor  shall have been  elected  and  qualified,  or until  such  director's
earlier death,  resignation or removal. Each nominee listed below is currently a
director of the Company.

Directors are elected by a plurality of the votes cast. Proxies may not vote for
more  than the  number  of  candidates  which  have  been  nominated.  It is the
intention of the persons named in the enclosed proxy, unless authorization to do
so is  withheld,  to vote the proxies  received by them for the  election of the
seven nominees named below. If, prior to the Annual Meeting,  any nominee should
become  unavailable  for election,  an event which is not now anticipated by the
Board, the proxies will be voted for the election of such substitute  nominee or
nominees as the Board of Directors may propose.

MANAGEMENT RECOMMENDS A VOTE IN FAVOR OF EACH NOMINEE.


<PAGE> 5


Nominees

The names of the  nominees  and  certain  information  about  them are set forth
below:

Name                       Age    Principal Occupation

Andre de Bruin              50    Chairman of the Board, President and
                                  Chief Executive Officer

Carlos A. Ferrer            43    General Partner of Ferrer Freeman Thompson &
                                  Co., the General Partner and Management
                                  Company of Health Care Capital Partners, L.P.

Bernadine Healy, M.D.       51    Dean of the College of Medicine and Professor
                                  of Internal Medicine at The Ohio State
                                  University

Gene I. Miller (1) (2)      55    General Partner of Miller & LaHaye, L.P.,
                                  the General Partner of Peregrine Ventures II

George B.Rathmann, Ph.D.(1) 69    Chairman of the Board, Chief Executive Officer
                                  and President of ICOS Corporation

Jack W. Schuler (2)         56    Chairman of the Board of Stericycle, Inc.,
                                  Chairman of the Board of Ventana Medical
                                  Systems, Inc.

Ralph Snyderman, M.D.       57    Chancellor for Health Affairs and Dean of the
                                  School of Medicine at the Duke University
                                  Medical Center

(1) Member of the Compensation Committee
(2) Member of the Audit Committee

Nominees for Election as Director

ANDRE DE BRUIN
Mr. de Bruin was appointed  President and Chief  Executive  Officer in July 1994
and  appointed to the Board of Directors in August 1994.  He also was  appointed
Chairman of the Board in January 1996.  From 1989 until June 1994,  Mr. de Bruin
was Chairman,  President  and Chief  Executive  Officer of  Boehringer  Mannheim
Corporation,  Indianapolis,  Indiana,  a  U.S. subsidiary  of  Corange  Ltd.,  a
private, global healthcare corporation. Mr. de Bruin also serves on the Board of
Directors  of  Diametrics  Medical,  Inc.  and is Vice  Chairman of the Board of
Directors of Quidel Corporation.


<PAGE> 6


CARLOS A. FERRER
Mr.  Ferrer  became a director in July 1996.  Since  October 1995, he has been a
General  Partner of Ferrer  Freeman  Thompson & Co.,  the  General  Partner  and
Management Company of Health Care Capital Partners,  L.P., a private equity fund
investing  exclusively in the Health Care industry.  Previously,  Mr. Ferrer was
Managing Director and Head of Global Health Care Investment  Banking at CS First
Boston Inc.  where he was employed  since July 1978. Mr. Ferrer is a Director of
Gensia Sicor,  Inc.,  Americaid,  Inc., and Chairman of the Board of Trustees of
the Cancer Research Institute, a not-for-profit research institution.

BERNADINE HEALY
Dr. Healy  became a director in March 1996.  She has been Dean of the College of
Medicine and Public Health, and Professor of Internal Medicine at The Ohio State
University  since October 1995 and Senior  Policy  Advisor at the Page Center of
the Cleveland  Clinic  Foundation since July 1994. Dr. Healy was the Director of
the National Institute of Health (NIH) from April 1991 to June 1993. Immediately
prior to her  appointment  at the NIH,  Dr.  Healy was  Chairman of the Research
Institute of the Cleveland Clinic  Foundation from September 1985 to April 1991,
and was a staff member of the Clinic's  Department of Cardiology.  From February
1984 to September  1985, Dr. Healy was Deputy  Director of the Office of Science
and Technology Policy at the White House and Chairman of the White House Cabinet
Working Group on Biotechnology.  She additionally  served as a member of several
advisory  groups,  including the Councils of the National Heart,  Lung and Blood
Institute, and President of the American Heart Association.  Dr. Healy serves on
the Board of Directors of Medtronic, Inc., National City Corporation, Karrington
Health, Inc. and Invacare Corporation.

GENE I. MILLER
Mr. Miller  became a director in October 1988. He has been a General  Partner of
Miller and LaHaye,  L.P. ("M&L"),  the General Partner of Peregrine Ventures II,
L.P., a private  venture capital firm  ("Peregrine"),  since 1984 and, from 1981
until  1984,  Mr.  Miller was a General  Partner of  Peregrine  Associates,  the
General  Partner of Peregrine  Ventures,  a private  venture  capital firm.  Mr.
Miller currently serves on the Board of Digital Transmission  Systems,  Inc. and
Raytel Medical Corporation.

GEORGE B. RATHMANN
Dr.  Rathmann  became a director in June 1989.  He is currently  Chairman of the
Board,   Chief  Executive   Officer  and  President  of  ICOS   Corporation,   a
biotechnology  company  which he  founded  in July  1990.  He is also  currently
Chairman  Emeritus  of Amgen Inc.,  a  biopharmaceutical  company.  From 1981 to
October 1988, Dr. Rathmann  served as President and Chief  Executive  Officer of
Amgen and from February 1986 to July 1990 as Chairman of the Board of Amgen. Dr.
Rathmann currently serves on the Board of Hedral Therapeutics, Inc.


<PAGE> 7



JACK W. SCHULER
Mr.  Schuler has been a director since June 1991. He is Chairman of the Board of
Stericycle,  Inc., a company that  processes,  sterilizes  and recycles  medical
waste,  since January 1990. Mr. Schuler is also Chairman of the Board of Ventana
Medical   Systems,    Inc.,   a   company   that   develops   and   manufactures
instruments/reagents  that automate  immunohistochemistry,  since November 1995.
From  1972  to  1989,  Mr.  Schuler  was  employed  by  Abbott  Laboratories,  a
pharmaceutical  company,  and served as President and Chief Operating Officer of
Abbott from 1987 to 1989 and on the Abbott Board of Directors from 1985 to 1989.
Mr. Schuler is a member of the Board of Directors of Chiron, Inc. and Medtronic,
Inc.

RALPH SNYDERMAN
Dr. Snyderman became a director in March 1989. He has been Chancellor for Health
Affairs and Dean of the School of Medicine at the Duke University Medical Center
since May 1989 and was formerly  Senior Vice  President of Medical  Research and
Development at Genentech, Inc. from January 1987 to May 1989. Dr. Snyderman also
serves on the Board of Directors of Proctor and Gamble, Inc.


Board Committees and Meetings

During  the  fiscal  year  ended  June 30,  1997  ("fiscal  1997")  the Board of
Directors held four meetings.  The Board of Directors has an Audit Committee and
a Compensation Committee.

The Audit  Committee meets with the Company's  independent  accountants at least
annually  to review the results of the annual  audit and  discuss the  financial
statements;  recommends to the Board the independent accountants to be retained;
and receives and considers the independent accountants' comments as to controls,
adequacy of staff and management  performance  and procedures in connection with
audit  and  financial   controls.   The  Audit  Committee  is  composed  of  two
non-employee  directors:  Messrs.  Miller and Schuler.  The  Committee met twice
during fiscal 1997.

The  Compensation  Committee  makes  recommendations   concerning  salaries  and
incentive compensation,  awards stock options to employees and consultants under
the  Company's  stock option plans and performs such other  functions  regarding
compensation as the Board may delegate.  The Compensation  Committee is composed
of two non-employee  directors:  Mr. Miller and Dr. Rathmann.  The Committee met
twice during fiscal 1997.

During fiscal 1997, each director attended each of the meetings of the Board and
the committees on which he or she served.




<PAGE>  8


                                   PROPOSAL 2

               APPROVAL OF NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN

In July 1993, the Company  adopted its  Non-Employee  Director Stock Option Plan
(the  "Directors'  Plan"),  under which 150,000 shares of Common Stock have been
reserved for issuance.  In October 1995, the stockholders  approved an amendment
to the  Directors'  Plan to increase  the  aggregate  number of shares of Common
Stock  authorized  for issuance  under such plan by 120,000  shares.  Options to
purchase 172,876 shares are outstanding under the Directors' Plan and 90,456 are
available for future option grants. In July 1997, the Board adopted an amendment
to the Directors' Plan which is subject to stockholder  approval. In addition to
clarifying  certain  provisions of the Directors' Plan, the amendment  increases
the number of shares of Common Stock  available  for grant under the  Directors'
Plan from 270,000 to 470,000 shares,  provides a directors'  deferred fee option
grant  attribute,  provides for acceleration of vesting in the event of a change
in control of the Company, and increases  non-discretionary  stock option grants
to cover 15,000  shares upon initial  appointment  to the Board and annual stock
option grants  thereafter at no less than 7,500 and no more than 15,000  shares,
respectively, as determined by the terms of the Directors' Plan.

The Board adopted the amendment to the  Directors'  Plan in order to provide its
current non-employee directors, together with any non-employee directors who may
in the future serve on the Board,  with  additional  incentives to exert maximum
efforts for the success of the Company.

Stockholders  are  requested  in this  Proposal to approve the  amendment to the
Director's Plan. The affirmative vote of the holders of a majority of the shares
represented  and entitled to vote at the meeting will be required to approve the
Directors' Plan.

MANAGEMENT RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 2.

The essential features of the Directors' Plan are outlined below.

General

The Directors' Plan provides for  non-discretionary  grants of stock options to
purchase shares of the Company's  Common Stock. The Directors' Plan also permits
non-employee directors to defer the receipt of fees in cash and receive  future
payment  of  those  fees in the  form of  discounted  stock  options,  with  the
aggregate discount equal to the amount of the fee  deferral,  to  acquire  the
Company's Common Stock.  Options granted under the Directors' Plan are intended
not to qualify as incentive  stock options  within the meaning of Section 422 of
the Internal Revenue Code of 1986, as amended (the "Code").  See "Federal Income
Tax  Information"  below for a discussion of the tax  treatment of  nonstatutory
stock options.


<PAGE> 9



Purpose

The Company,  by means of the Directors'  Plan,  seeks to retain the services of
persons now serving as  non-employee  directors  to the  Company,  to secure and
retain the  services  of persons  capable  of  serving in such  capacity  and to
provide  incentives for such persons to exert maximum efforts for the success of
the Company.  All  non-employee  directors are eligible to receive options under
the Directors' Plan.

Administration

The Directors' Plan is administered by the Board of Directors. The Board has the
power to  construe  and  interpret  the  Directors'  Plan and is  authorized  to
delegate  administration of such plan to a committee  composed of not fewer than
two  members of the Board (the  "Committee").  The Board of  Directors  does not
presently  contemplate  delegating  administration of the Directors' Plan to any
committee of the Board of Directors.

As used herein with respect to the  Directors  Plan,  the "Board"  refers to the
Committee as well as to the Board of Directors itself.

Eligibility

Only non-employee directors of the Company are eligible to receive options under
the Directors'  Plan. A non-employee  director is defined in the Directors' Plan
as a member of the Board of  Directors  who is not  otherwise an employee of the
Company.  Six of the Company's seven current directors (all except Mr. de Bruin)
are eligible to participate in the Directors' Plan.

Stock Subject to the Directors' Plan

An aggregate of 470,000 shares of Common Stock have been authorized for issuance
under the Directors'  Plan,  subject to  stockholder  approval of Proposal 2. If
options  granted under the Directors'  Plan expire without having been exercised
in full,  the  stock  not  purchased  pursuant  to such  options  again  becomes
available for issuance under the Directors' Plan.

Non-Discretionary Option Grants

The following is a description of the terms of  non-discretionary  option grants
under the Directors' Plan.

Initial Grant. On the date of initial election to the Board,  each  non-employee
director is granted a stock option to purchase  15,000  shares of Common  Stock,
subject to stockholder approval of Proposal 2.

<PAGE> 10

Annual Grant. Subject to stockholder approval of Proposal 2, on the date of each
Annual Meeting of Stockholders of each year,  commencing on the date of the 1998
Annual Meeting, each non-employee director who is then a member of the Company's
Board of  Directors  will  receive  an  option  to  purchase  a number of shares
determined by the following  formula:  7,500 times a fraction,  the numerator of
which is $20 and the  denominator  of which is the  closing  sales  price of the
Company's  Common Stock on such date.  The minimum  annual  option grant will be
7,500 shares and the maximum annual option grant will be 15,000 shares.

Option  Exercise.  Non-discretionary  stock  option  grants  become  exercisable
("vest") in equal quarterly  installments  over a period of three years, so long
as the optionee continues to serve as a director of the Company, and, subject to
stockholder approval of Proposal 2, become fully vested in the event of a change
in control of the Company.  As defined  under the  Directors'  Plan, a change in
control  occurs if (i) any  person (as such term is used in  Sections  23(d) and
14(d)(2) of the Securities and Exchange Act of 1934 (the "Exchange Act"),  other
than the Company,  is or becomes the beneficial  owner (as defined in Rule 13D-3
under the Exchange Act), directly or indirectly,  of 50% or more of the combined
voting power of the outstanding  shares of capital stock of the Company entitled
to vote  generally in the election of directors  (calculated as provided in Rule
13d-3(d) under the Exchange Act in the case of rights to acquire capital stock),
whether by means of a tender offer or exchange offer,  Transaction or otherwise;
or (ii) the Board or the  stockholders of the Company  approve a Transaction.  A
"Transaction"  is: (a) any  consolidation  or merger of the Company other than a
merger solely to effect a reincorporation or a merger of the Company as to which
stockholder  approval is not required  pursuant to Sections 251(f) or 253 of the
Delaware  General  Corporation  Law; or (b) any sale,  lease,  exchange or other
transfer (in one transaction or a series of related transactions) of 50% or more
of the assets of the  Company;  or (c) the  adoption of any plan or proposal for
the liquidation or dissolution of the Company.

Exercise  Price:  Payment.  The exercise  price of all  non-discretionary  stock
options granted under the Directors' Plan is the fair market value of the Common
Stock on the date on which the option is granted.  The exercise price of options
granted must be paid in cash at the time the option is exercised.

Term.  Non-discretionary  option grants under the Directors'  Plan have terms of
six years.  An option may be exercised  following  termination of the optionee's
service as a non-employee director of the Company only for that number of shares
for  which it was  exercisable  on the  date of  termination  of such  services.
Subject to the maximum  six-year  term,  options  remain  exercisable  for three
months following termination of service as a director (twelve months in the case
of termination because of disability or death).

Non-Employee Director Fee Deferral Option Grants

Subject to stockholder approval of Proposal 2, non-employee  directors may elect
to defer their fees  otherwise  payable in cash,  in return for stock options to
purchase  Common Stock at an aggregate  discount  from current fair market value
equal to the deferred fee amount.

Deferred Election.  Elections to defer fees must be filed with the Company prior
to the Annual Meeting.  Options granted pursuant to a fee deferral election will
be granted on the date of the Annual Meeting.  The elections apply to fees which
will be earned  during the year  immediately  following  the date of grant.  The
deferral  election shall be irrevocable until the Annual Meeting of Stockholders
of the following year.


<PAGE> 11



Number of Shares.  The number of shares of Common  Stock  subject to each option
shall be equal to A/(Bx66-2/3%), where A is the fee deferral amount and B is the
fair market value per share of Common Stock on the date of grant.  The number of
shares shall be rounded down to the nearest whole number.

Exercise  Price.  The exercise  price of each option  granted  pursuant to a fee
deferral  election shall be 33-1/3% of the fair market value of the Common Stock
subject  to such  option on the date such  option is  granted.  For  example,  a
director  anticipates  receipt of meeting  fees  totaling  $5,000.  The director
elects to defer all of those fees.  If the fair market value of a share of stock
is $6.00 then the director  will  receive an option to purchase  1,250 shares of
common stock at an exercise  price of $2.00 per share.  Note that the  aggregate
discount  purchase  price for the option is $5,000 which is the equal to the fee
deferral amount.

Vesting Term. Such options become  exercisable in installments on each date that
director  fees would have been  payable in cash had no  deferral  election  been
made,  and shall  terminate  on the  earlier  of (i) six years from the date the
option was granted,  or, (ii) three years  following  termination  of his or her
relationship as a director. The terms of deferred fee option grants as set forth
in  the  Directors'  Plan  provide  for  options  to  become  fully  vested  and
exercisable  in the event of a change in control of the  Company or in the event
the non-employee director dies or becomes disabled.

Adjustment Provisions

If there are any changes made to the shares of Common  Stock  (whether by reason
of merger, consolidation,  reorganization,  recapitalization,  stock dividend in
excess of ten percent  (10%) at any single  time,  stock split,  combination  of
shares,  exchange  of  shares,  change in  corporate  structure  or  otherwise),
appropriate  adjustments  shall be made in:  (i) the  number of shares of Common
Stock  theretofore  made subject to stock options,  and in the purchase price of
such shares;  and (ii) the aggregate  number of shares which may be made subject
to stock options.

<PAGE> 12

Restrictions on Transfer

Under the  Directors'  Plan,  an option may not be  transferred  by the optionee
other than by will or by laws of  descent  and  distribution  or  pursuant  to a
(qualified)  domestic  relations order.  During the lifetime of an optionee,  an
option  may be  exercised  only by the  optionee,  or by his  guardian  or legal
representative.

Effect of Certain Corporate Events

If the Company or its stockholders enter into an agreement to dispose of all, or
substantially all, of the assets or outstanding  capital stock of the Company by
means of a sale or  liquidation,  or a merger  or  reorganization  in which  the
Company is not the surviving corporation, the Committee shall have the power and
discretion  to  prescribe  the  terms and  conditions  for the  exercise  of, or
modification of, the stock options granted under the plan.

Duration, Amendment and Termination

The Board may alter,  amend,  suspend or discontinue  the Directors' Plan at any
time.  However,  no  such  action  will  be  effective  unless  approved  by the
stockholders of the Company where such approval is required to conform to Nasdaq
or exchange listing requirements.

Federal Income Tax Information

The  following  is a summary  of the effect of federal  income  taxation  on the
optionee and the Company with respect to the grant and exercise of options under
the Directors' Plan.

Stock options  granted under the  Directors'  Plan are subject to federal income
tax treatment  pursuant to rules governing  options that are not incentive stock
options.

Options granted under the Directors' Plan are nonstatutory options. There are no
tax consequences to the optionee or the Company  resulting from the nonstatutory
stock option grant. Upon exercise of a nonstatutory  stock option,  the optionee
generally will recognize ordinary income for tax purposes measured by the excess
of the then fair market value of the shares over the option  price.  At the time
the optionee  recognizes  ordinary income due to the exercise of the option, the
Company  generally will be entitled to a business expense deduction equal to the
taxable ordinary income realized by the optionee.  Upon resale of such shares by
the optionee,  any difference between the sales price and the exercise price, to
the extent not recognized as ordinary income as provided  above,  generally will
be treated as capital gain or loss,  and will qualify for mid-term  capital gain
or loss  treatment  if the shares  have been held for more than one year and for
long-term  capital gain or loss  treatment if the shares have been held for more
than 18 months.


<PAGE> 13




                                   PROPOSAL 3

              RATIFICATION OF SELECTION OF INDEPENDENT ACCOUNTANTS

The Board of  Directors  has  selected  Price  Waterhouse  LLP as the  Company's
independent accountants for the fiscal year ending June 30, 1998 and has further
directed that  management  submit the selection of independent  accountants  for
ratification by the stockholders at the Annual Meeting. Representatives of Price
Waterhouse  LLP are expected to be present at the Annual  Meeting,  will have an
opportunity  to make a  statement  if they so desire  and will be  available  to
respond to appropriate questions.

Stockholder  ratification  of  the  selection  of  Price  Waterhouse  LLP as the
Company's  independent  accountants is not required by the Company's  By-laws or
otherwise.  However,  the Board is submitting the selection of Price  Waterhouse
LLP to the stockholders for ratification as a matter of good corporate practice.
If the  stockholders  fail to ratify the selection,  the Audit Committee and the
Board will reconsider  whether or not to retain that firm. Even if the selection
is ratified,  the Audit  Committee and the Board in their  discretion may direct
the  appointment of a different  independent  accounting firm at any time during
the year if they  determine  that such a change would be in the best interest of
the Company and its stockholders.

The affirmative vote of the holders of a majority of the shares  represented and
entitled to vote at the meeting  will be  required  to ratify the  selection  of
Price Waterhouse LLP.

MANAGEMENT RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 3.




<PAGE> 14



                    SECURITY OWNERSHIP OF DIRECTORS, OFFICERS
                          AND CERTAIN BENEFICIAL OWNERS

The  following  table  sets  forth  certain  information   regarding  beneficial
ownership  of the  Company's  Common  Stock,  as of July  31,  1997 by (i)  each
director of the  Company;  (ii) each Named  Executive  Officer  (as  hereinafter
defined);  (iii) all executive  officers and directors as a group;  and (iv) all
those known by the Company to be beneficial  owners of more than five percent of
its Common Stock.

<TABLE>
<CAPTION>
                                                                                              Percentage
                                                                                             Beneficially
                                                                     Number of Shares (1)      Owned(2)
<S>                                                                        <C>                   <C>

     Eli Lilly and Company.............................................    2,954,104             14.2%
         Lilly Corporate Center
         Indianapolis, Indiana  46285

     Zesiger Capital Group LLC.........................................    1,067,400              5.1
         320 Park Avenue
         New York, NY  10022

     Gene Miller (3)...................................................      460,616              2.2

     Jack W. Schuler (4)...............................................      258,419              1.2

     Andre de Bruin ...................................................      223,602              1.1

     Bernadine Healy...................................................       11,323               *

     Carlos A. Ferrer..................................................       17,369               *

     George B. Rathmann (5)............................................       76,464               *

     Ralph Snyderman...................................................       97,339               *

     Robert F. Caspari.................................................       51,236               *

     J. William Freytag................................................       68,418               *

     Richard J. Gorczynski.............................................       47,920               *

     Timothy D. Hoogheem...............................................       85,413               *

     All directors and executive officers as a group
     (14 persons) (2), (3)-(6).........................................    1,483,565              6.9

</TABLE>
- ----------------

*    Less than one percent


<PAGE> 15



(1)   This table is based upon information  supplied by officers,  directors and
      principal  stockholders.  Unless  otherwise  indicated in the footnotes to
      this table and subject to community  property laws where applicable,  each
      of the  stockholders  named in this table has sole  voting and  investment
      power  with  respect  to  the  shares  indicated  as  beneficially  owned.
      Percentage  of  ownership  is based on  20,870,621  shares of Common Stock
      outstanding as of July 31, 1997 adjusted as required by rules  promulgated
      by the Securities and Exchange Commission ("SEC").

(2)   Shares of  Common  Stock  subject  to  options  currently  exercisable  or
      exercisable  within 60 days of July 31, 1997, are deemed  outstanding  for
      computing the percentage of the person or entity  holding such  securities
      but are not  outstanding  for computing the percentage of any other person
      or entity.  Except as  indicated  by  footnote,  and subject to  community
      property laws where applicable,  the persons named in the table above have
      sole  voting and  investment  power  with  respect to all shares of Common
      Stock shown as beneficially owned by them. Includes an aggregate number of
      shares  that  may be  issuable  upon  exercise  within  60 days  for  each
      individual as follows: Mr. Miller, 26,464; Mr. Schuler, 26,464; Dr. Healy,
      8,323; Dr. Rathmann, 26,464; Dr. Snyderman, 49,589; Mr. Ferrer, 7,369; Mr.
      de  Bruin,  222,538;  Dr.  Caspari,   48,856;  Dr.  Freytag,  52,296;  Dr.
      Gorczynski,  46,609; and Mr. Hoogheem, 82,671; all directors and executive
      officers as a group (14 persons), 648,611.

 (3)  Includes  433,952  shares  held of record by  Peregrine.  Mr.  Miller is a
      General  Partner of M&L,  the General  Partner of  Peregrine.  Mr.  Miller
      shares voting and investment  power with respect to such shares and may be
      deemed to be the beneficial owner of such shares. Also includes 200 shares
      held by Mr. Miller's spouse as to which he disclaims beneficial ownership.

 (4)  Includes  7,000 shares owned by Mr.  Schuler's  spouse and an aggregate of
      600  shares  owned by Mr.  Schuler's  spouse  as joint  tenant  with or as
      custodian for Mr. Schuler's children.

 (5)  Includes  12,500  shares owned by Falcon  Technology  Partners,  a Limited
      Partnership of which Dr. Rathmann is a Limited Partner.

 (6)  Includes 250 shares held by an officer's spouse.


<PAGE> 16


Compliance with Section 16(a) of the Securities Exchange Act of 1934

Section 16(a) of the Exchange Act requires the  Company's  directors and certain
officers, and persons who own more than ten percent of a registered class of the
Company's equity  securities,  to file with the SEC initial reports of ownership
and reports of changes in ownership of Common Stock and other equity  securities
of the Company.  Officers,  directors and greater than ten percent  stockholders
are required by Commission  regulation to furnish the Company with copies of all
Section 16(a) forms they file.

To the  Company's  knowledge,  based  solely on a review  of the  copies of such
reports  furnished  to the  Company and  written  representations  that no other
reports  were  required,  for the fiscal year ended June 30,  1997,  all Section
16(a) filing requirements applicable to its officers, directors and greater than
ten percent beneficial owners were complied with.



                             EXECUTIVE COMPENSATION


Compensation of Directors

During  fiscal  1997,  directors  of the Company who were not  employees  of the
Company were not paid any cash  compensation  for their  service on the Board of
Directors (the "Board") or any committees thereof.  The members of the Board are
eligible for reimbursement of expenses incurred in connection with their service
on the Board. Effective July 22, 1997, non-employee directors of the Company who
are not salaried  officers or  employees  receive a fee of $3,000 for each Board
meeting attended and $1,000 for  participation in each telephonic Board meeting.
For Committee meetings held on non-Board meeting dates,  non-employee  directors
receive  $750 for each  meeting  attended  and  $250 for  participation  in each
telephonic meeting.

Upon appointment to the Board,  non-employee directors are eligible to receive a
stock option grant.  Subject to stockholder approval of Proposal 2, non-employee
directors  will receive a  non-discretionary  option grant of 15,000 shares from
the Directors' Plan upon initial appointment to the Board.

On the date of each Annual Meeting, each non-employee director who is elected as
a director  at such  meeting  will be  automatically  granted a stock  option to
purchase a number of shares of Common Stock determined by multiplying 7,500 by a
fraction,  the numerator of which is $20.00 and the  denominator of which is the
fair  market  value of one share of Common  Stock on such  date.  The  number of
shares subject to each annual stock option grant will not exceed 10,000 and will
not be less than  5,000.  Subject to  stockholder  approval  of  Proposal 2, the
maximum  and  minimum  number of shares  covered  by the  option  grant  will be
increased  to 15,000  and 7,500  shares,  respectively.  The  exercise  price of
non-discretionary options granted under the Directors' Plan is equal to the fair
market  value of the  Company's  Common  Stock on the date of the option  grant.
Non-discretionary  options  granted  under  the  Directors'  Plan  vest in equal
quarterly  installments  over a period of three  years from grant and expire six
years after the date of grant.
<PAGE> 17

On July 22, 1997, in lieu of the non-discretionary option grant which would have
been made on the date of this year's  Annual  Meeting,  the  Company  granted an
option to purchase 15,000 shares of Common Stock to each  non-employee  director
at an exercise price of $4.75 per share,  the fair market value of the Company's
Common  Stock  on the  date  of  grant.  The  options  vest in  equal  quarterly
installments  over a period of three  years and  expire  after  six  years.  The
options were granted under the provisions of the Company's  Amended and Restated
Stock Option Plan (the "Stock Option Plan").

In connection with the Annual Meeting of Stockholders  held on October 31, 1996,
and pursuant to the terms and  provisions of the  Directors'  Plan,  the Company
granted  options  covering  10,000  shares of Common Stock to each  non-employee
director at an exercise price of $10.625, the fair market value of the Company's
Common Stock on the date of grant.

Subject to  stockholder  approval of Proposal 2, the amendment to the Directors'
Plan  provides  that in  addition  to  non-discretionary  stock  option  grants,
non-employee directors may elect to defer the payment of fees for their services
as directors and apply such  deferrals to options with exercise  prices set at a
discount  to market with the  aggregate  amount of such  discounts  equal to the
aggregate  amount of the fees so  deferred.  Non-employee  director fee deferral
options are granted at an aggregate discount which is equal to the aggregate fee
deferral and vest as fees are earned.

As of June 30, 1997, 6,668 options had been exercised under the Directors' Plan.



<PAGE> 18



Compensation of Executive Officers

                             Summary of Compensation

The following table reflects for the fiscal years ending June 30, 1997, 1996 and
1995, certain compensation awarded or paid to, or earned by, the Company's Chief
Executive Officer and its other four most highly compensated  executive officers
at June 30, 1997 (the "Named Executive Officers"):

<TABLE>
<CAPTION>

                           Summary Compensation Table

                                                                                Long-Term
                                                                              Compensation
                                                                                 Awards
                                                                              ------------
                                        Annual Compensation          Other     Securities
                                        -------------------          Annual    Underlying       All Other
                                   Fiscal    Salary     Bonus     Compensation   Options       Compensation
Name and Principal Position         Year      ($)        ($)        ($)  (1)       (#)           ($)  (2)
- ----------------------------        ----    -------     ------      --------     -------       ------------
<S>                                <C>      <C>         <C>         <C>          <C>              <C>

Andre de Bruin                      1997    321,012     47,609             0      30,000           4,900
   Chairman of the Board,           1996    300,000     47,632             0           0           5,053
   President and CEO                1995    300,000     47,621             0     500,000           2,944

Robert F. Caspari, M.D. (3)         1997    219,079          0             0      17,000           4,855
   Senior Vice President of Medical 1996    210,000     25,000         1,031           0           4,620
   and Regulatory Affairs           1995    141,500     25,000       135,189     110,000           4,620

J. William Freytag, Ph.D. (3)       1997    215,993     19,994             0      19,500           4,750
   Senior Vice President of         1996    205,000     20,000             0       5,000           4,750
   Technology and Business          1995    141,900     20,000        96,272     110,000           4,620
   Development

Timothy D. Hoogheem                 1997    180,932          0             0      54,500           5,183
   Senior Vice President of Finance 1996    163,260          0             0       5,000           4,851
   and Administration, Chief        1995    154,000          0             0      10,000           5,064
   Financial Officer and Treasurer

Richard J. Gorczynski, Ph.D. (3)    1997    196,335     30,000        21,932      19,500           4,904
   Vice President of Research and   1996    185,520     30,000         9,368       2,000           4,620
   Development                      1995     96,300     30,000        35,605     100,000           2,783

</TABLE>

- -----------------------------------------
(1) Represents solely relocation expenses reimbursed by Somatogen.

(2)  Represents  solely employer matching  contributions to the Somatogen,  Inc.
     Custom 401(k) Plan (the "401(k) Plan") paid in shares of Common Stock which
     vest over a four-year period commencing as of the employee's hire date.

(3)  Drs.  Freytag,  Caspari and Gorczynski  joined the Company in October 1994,
     October 1994 and December 1994,  respectively.  For fiscal 1995, salary and
     bonus for these officers represent amounts earned from the date they joined
     the Company through June 30, 1995.


<PAGE> 19



                        Stock Option Grants And Exercises

The Company  grants  options to its  executive  officers  under its Stock Option
Plan. As of June 30, 1997,  options to purchase a total of 2,539,691 shares were
outstanding  under the Plan and  options to  purchase  955,937  shares  remained
available for grant thereunder.

The  following  tables  show for the fiscal  year ended June 30,  1997,  certain
information regarding options granted to, exercised by, and held at year-end by,
the Named Executive Officers:

<TABLE>
<CAPTION>

                         Option Grants in Last Fiscal Year
                                   Individual Grants
                                                                               Potential Realizable Value
                                                                                at Assumed Annual Rates
                      Number of       % of Total                                    of Stock Price
                      Securities       Options                                  Appreciation for Option
                      Underlying      Granted to    Exercise                             Term(3)
                       Options       Employees in   Price per                   ------------------------
Name                Granted (#)(1)  Fiscal Year(2)  Share ($)   Expiration Date      5%          10%
- -----               --------------  --------------  ---------   ---------------    ------      ------
<S>                      <C>            <C>         <C>           <C>              <C>        <C>


Andre de Bruin           10,000         1.2%         10.625       10/31/2002       $36,135    $81,978
                         20,000         2.5           5.625       05/02/2003        38,261     86,801

Robert F. Caspari         5,000         0.6          10.625       10/31/2002        18,068     40,989
                         12,000         1.5           5.625       05/02/2003        22,956     52,080

J. William Freytag        7,500         0.9          10.625       10/31/2002        27,101     61,484
                         12,000         1.5           5.625       05/02/2003        22,956     52,080

Timothy D. Hoogheem      35,000         4.4          11.500       07/16/2002       136,888    310,553
                          7,500         0.9          10.625       10/31/2002        27,101     61,484
                         12,000         1.5           5.625       05/02/2003        22,956     52,080

Richard J. Gorczynski     7,500         0.9          10.625       10/31/2002        27,101     61,484
                         12,000         1.5           5.625       05/02/2003        22,956     52,080

</TABLE>

- ----------------------------------

(1)  Options granted in fiscal 1997 have a six-year term and vest quarterly over
     a period of two to five years.

(2)  Based on 802,690 options granted to employees in fiscal 1997.

(3)  The  potential  realizable  value is based on the term of the option at its
     time of grant (six years in the case of the options  listed  above).  It is
     calculated  by  assuming  that  the  stock  price  on  the  date  of  grant
     appreciates  at the  indicated  annual  rate,  compounded  annually for the
     entire term of the option and that the option is exercised  and sold on the
     last  day of its  term  for the  appreciated  stock  price.  These  amounts
     represent  certain assumed rates of  appreciation  only, in accordance with
     the  rules  of the  SEC,  and do not  reflect  the  Company's  estimate  or
     projection of future stock price  performance.  Actual  gains,  if any, are
     dependent on the actual future  performance  of the Company's  Common Stock
     and no gain to the  optionee is possible  unless the stock price  increased
     over the option term, which will benefit all stockholders.

<PAGE> 20

<TABLE>
<CAPTION>

                         Aggregated Option Exercises in
               Last Fiscal Year and Fiscal Year-End Option Values

                                                       Number of Unexercised
                                                       Securities Underlying     Value of Unexercised In-
                                                           Options at              the-Money Options at
                                                        Fiscal Year-End             Fiscal Year-End (2)
                             Shares      Value      --------------------------  ---------------------------
                          Acquired on  Realized     Exercisable  Unexercisable  Exercisable   Unexercisable
      Name                Exercise (#) ($)  (1)         (#)         (#)             ($)            ($)
- ---------------------     ------------ --------    ------------  -------------  -----------   -------------
<S>                           <C>         <C>        <C>          <C>               <C>           <C>

Andre de Bruin                 --          --        218,288      311,712            --           --

Robert F. Caspari              --          --         46,444       80,556            --           --

J. William Freytag             --          --         49,417       85,083            --           --

Timothy D. Hoogheem            --          --         75,542       53,958            --           --

Richard J. Gorczynski          --          --         43,916       77,584            --           --

</TABLE>

- ----------------------------

(1)  Value  realized is based on the fair market value of the  Company's  Common
     Stock on the date of exercise less the exercise price.

(2)  Calculated  on the basis of the closing sale price per share for the Common
     Stock as quoted on The Nasdaq Stock Market of $4.625 on June 30, 1997,
     less the exercise price.


Discretionary Stock Option Grant

In April  1997,  the  Company  reprioritized  its  projects  as a result  of the
termination  of  the  strategic  alliance  with  Eli  Lilly  and  Company.   The
reprioritization of projects resulted in a staff reduction of 67 employees. As a
retention incentive to remaining  employees,  the Compensation  Committee,  at a
regularly  scheduled  meeting held May 2, 1997,  approved a discretionary  stock
option  grant.  Pursuant to the terms of the stock  option grant as set forth by
the Compensation Committee, the options granted to employees vest quarterly over
a two year  period  and  expire  six years  from the date of grant.  Options  to
purchase a total of 307,000  shares of the Company's  Common Stock at $5.625 per
share were granted.

<PAGE> 21

Employment Agreements

On  July  25,  1997,  the  Company   entered  into  agreements  (the  "Retention
Agreements")  with each of the Named  Executive  Officers  and three  other vice
presidents  of  the  Company  (individually,  the  "Executive").  The  Retention
Agreements  provide  that if within  one year of (i) a change in  control of the
Company,  (ii) or a change in the chief  executive  officer  or chief  operating
officer,  (a) the Executive's  employment is terminated without cause or (b) the
Executive voluntarily leaves after any of (i) a reduction in salary or benefits;
(ii)  a  substantial   change  in  the  nature  or  status  of  the  Executive's
responsibilities  or the  assignment  of duties to Executive  inconsistent  with
Executive's  position;  (iii) a relocation of the Company's  principal executive
offices to a location  outside of Boulder County;  (iv) a material breach of any
provision of the  Retention  Agreement  which has not been cured within 30 days;
or,  (v) a failure to assume  the  Retention  Agreement  by a  successor  to the
Company,  the Executive will receive severance  compensation equal to his or her
base salary, any bonus or other incentive  compensation,  including Company paid
health insurance benefits for a period of twelve months. Additionally, any stock
options held by the Executive shall fully vest and become  exercisable and shall
remain  exercisable  for a  period  of (i) 90  days  if the  termination  occurs
following  a change of control in which the  Company's  stock is  exchanged  for
consideration consisting of 75% or more cash; (ii) or twelve months in the event
of  termination  because  of the  Executive's  disability;  (iii)  or two  years
following  a  termination  of  employment  for any other  reason  entitling  the
Executive to severance  pay under the  Retention  Agreement.  Absent a change in
control or change in chief executive officer or appointment of a chief operating
officer, the Retention Agreements expire July 25, 1999. The Retention Agreements
may be  renewed  by written  agreement  of the  Executive  and the  Company  for
successive one year periods.

The Company  entered into an employment  agreement  effective June 24, 1994 with
Andre de Bruin. The employment  agreement provided for a base salary of $300,000
to be reviewed annually, an employment bonus of $142,862 which was paid biweekly
over a three-year period commencing on July 29, 1994 and it provides for a bonus
of up to 50 percent of his base  salary to be awarded at the  discretion  of the
Compensation  Committee.  The employment agreement also provided that if Mr. de
Bruin is terminated  without cause prior to the expiration of the aforementioned
three-year  period,  he would be entitled  to continue to receive the employment
bonus on a monthly  basis until it had been paid in full.  See the  Compensation
Committee  Report  for a  discussion  of  the  other  terms  of Mr.  de  Bruin's
compensation package.

Effective  October 17, 1994,  the Company  entered into an employment  agreement
with Dr.  Freytag.  The  employment  agreement  provides  for a base  salary  of
$205,000 to be reviewed  annually and an employment bonus of $100,000 payable in
equal annual  installments  of $20,000 over five years. In the event Dr. Freytag
voluntarily  terminates his  employment or leaves for cause,  the unpaid portion
will be forfeited.  Based on performance and achievement of mutually agreed upon
goals,  Dr.  Freytag  will be  eligible  to  receive a target  bonus of up to 40
percent  of his  base  salary.  The  Company  reimbursed  Dr.  Freytag  for  his
relocation  and also  provided  him with an interest  free bridge loan which was
repaid in fiscal 1996. If the Company  terminates Dr.  Freytag's  employment for
any reason other than cause or persistent  unsatisfactory  performance,  he will
receive severance compensation in an aggregate amount equal to base salary for a
period of six months. Corporate-paid health insurance will also continue for six
months after the termination date.

At the discretion of the  Compensation  Committee and based on  performance  and
achievement  of mutually  agreed upon goals,  Drs.  Caspari and  Gorczynski  are
eligible to receive target bonuses of up to 40 percent of their  respective base
salaries.

<PAGE> 22

Compensation Committee Report (1)

The  Compensation  Committee  of the Board of  Directors  (the  "Committee")  is
composed  of two  non-employee  directors,  Dr.  Rathmann  and Mr.  Miller.  The
Committee is responsible for setting the Company's  policies  governing employee
compensation and administering the Company's  employee benefit plans,  including
the Stock Option Plan,  the Somatogen,  Inc.  Custom 401(k) Savings Plan and the
Employee Stock Purchase Plan.

The Company's executive compensation programs are designed to attract and retain
executives capable of leading the Company to meet its business objectives and to
motivate them to enhance  long-term  stockholder  value. The Committee  annually
evaluates the performance and determines the compensation of the Chief Executive
Officer and other  executive  officers of the  Company,  based upon a mix of the
achievement  of corporate  goals,  individual  performance  and  comparisons  of
compensation   paid  to   executive   officers   of  other   biotechnology   and
biopharmaceutical  companies.  The competition for experienced  senior executive
officers in the biotechnology and  biopharmaceutical  industries is intense. The
Committee takes into account the compensation  paid by competing  companies from
survey  data to assist it in  determining  the  compensation  paid to  executive
officers of the Company.

The annual  compensation for the Company's  executive officers consists of three
components:  (i) a base salary;  (ii) an annual cash incentive;  and (iii) stock
option grants. Each of these components is described in detail below.

Base Salary:  Base salaries for executive officers are determined in the context
of a review of salaries for similar positions offered by the salary survey data.
According to current  survey data,  the  executive  officers'  base salaries are
currently  set  competitively  between the middle and high-end of the range when
compared to other biotechnology  companies.  The Committee generally reviews and
adjusts each executive officer's base salary on an annual basis.

Annual Cash Incentive  Plan: The annual cash incentive plan  established for the
executive,  management and other key employees to reward  participants for their
contributions to the achievement of Company-wide performance goals was suspended
for fiscal  years 1995,  1996 and 1997.  This plan may be  reestablished  by the
Board in the future.

Stock Option Plan:  The Stock  Option Plan has been  established  to provide all
employees of the Company,  including executive officers,  with an opportunity to
share, along with stockholders of the Company, in the benefits deriving from the
long-term performance of the Company.

- ----------------------
(1)   The material in this report is not  "soliciting  material,"  is not deemed
      filed  with  the SEC and is not to be  incorporated  by  reference  in any
      filing of the Company  under the  Securities  Act of 1933 as amended  (the
      "1933 Act") or the Securities  Exchange Act of 1934, as amended (the "1934
      Act"),  whether made before or after the date hereof and  irrespective  of
      any general incorporation language in any such filing.

<PAGE> 23

Grants of stock  options  have  generally  been granted to new  employees  upon
commencement  of  employment,  and on an annual basis to all eligible  employees
based on evaluations of individual  performance  levels.  Stock options  granted
under the Plan  generally have a four or five-year  vesting  schedule and expire
six to ten  years  from  the date of the  grant.  However,  in  order to  retain
employees  subsequent to the Company's April 1997 staff  reduction,  the Company
granted  options to purchase  307,000 shares of Common Stock at a purchase price
of $5.625 with quarterly  vesting over a period of two years. The exercise price
of  options  granted  under  the  Plan is 100% of the fair  market  value of the
underlying  stock on the date of grant.  In fiscal 1997,  the Committee  granted
options to officers to purchase an aggregate of 189,900  shares of Common Stock.
The Committee also granted options to other eligible employees in the Company to
purchase an aggregate of 612,790  shares of Common  Stock.  Options were awarded
based on  accomplishments  and progress toward targeted  individual  performance
objectives  for fiscal 1996  supporting  the  Company's  strategic  goals and to
retain employees after the April 1997 staff reduction.

In the future,  the Committee plans to continue the formalized stock bonus award
program that rewards  individual  job  performance  at all levels of the Company
commensurate  with  accomplishments  and  progress  toward  specific  individual
performance objectives established to support the Company's strategic goals.

The Company has amended its Stock Option Plan to comply with exclusions  related
to Section 162(m) of the Code relating to the  non-deductibility of compensation
of Named Executive Officers in excess of $1,000,000 per year.

Stock Option Exchange:  The Compensation  Committee,  at its regularly scheduled
meeting on July 16, 1996,  approved a stock option  exchange  plan for employees
who held stock  options at exercise  prices  ranging from $23.00 to $40.50.  The
exchange plan allowed  employees to exchange stock options with exercise  prices
in excess of $22.00 for the same  number of options at the then  current  market
value  of  $11.50.  The new  options  vest  quarterly  over a five  year  period
commencing  September 28, 1996, and have six year terms. Nine employees accepted
the exchange covering an aggregate of 85,000 shares,  including Mr. Hoogheem who
exchanged options to purchase 35,000 shares with an exercise price of $26.75 (of
which  options to  purchase  28,000  shares had  vested) for options to purchase
35,000 at an exercise price of $11.50.

In April 1997, the Board of Directors  approved a stock option exchange plan for
clinical  and  scientific  consultants  who held  stock  options  which had been
granted under the  Company's  Consultants  Stock Option Plan at exercise  prices
ranging  from  $14.25 to $20.125.  The  exchange  plan  allowed  consultants  to
exchange  their stock  options for options to purchase the same number of shares
at an exercise price of $5.625 per share, the fair market value of the Company's
stock on the date of  exchange.  The new  options  vest  quarterly  over two and
one-half  years and have six year terms.  Options to purchase  46,000  shares of
Common Stock were exchanged pursuant to the terms of the exchange offer.
<PAGE> 24

The  following  table shows  certain  information  concerning  the  repricing of
options received by the Named Executive Officers during the last ten years.

<TABLE>
<CAPTION>

                           Ten Year Option Repricings


                                                                                              Length of
                                      Number of      Market                                    Original
                                     Securities     Price of       Exercise                     Option
                                     Underlying     Stock at       Price at                     Term
                                       Options      Time of        Time of        New         Remaining
                                      Repriced     Repricing      Repricing     Exercise      at Date of
Name                    Date             (#)          ($)            ($)        Price ($)     Repricing
- ----                    ----          ---------     --------       --------     ---------     ----------
<S>                   <C>               <C>           <C>            <C>          <C>          <C>

Timothy D. Hoogheem   7/16/96           35,000        11.50          26.75        11.50        1.8 years

</TABLE>

Chief  Executive  Officer  Compensation:  The Committee used the same procedures
described  above for  setting the base  salary and stock  option  awards for the
Chief  Executive  Officer.  During the past  fiscal  year,  the Chief  Executive
Officer's  salary  was  determined  based  on  comparisons  with   biotechnology
companies  as  described  above.  Mr. de Bruin's  base salary was  increased  to
$320,000 in fiscal 1997 from $300,000 for each of the two previous fiscal years.
Mr. de Bruin's  compensation was reviewed in July 1997 and increased to $370,000
per annum. In connection with Mr. de Bruin's June 1994 employment with Somatogen
and pursuant to the terms of Mr. de Bruin's employment  agreement,  Mr. de Bruin
received an  employment  bonus of  $142,862  (paid  bi-weekly  over a three year
period).  The employment  bonus  represented  the portion of earned but unvested
compensation  Mr.  de  Bruin  lost as a result  of  departing  from  his  former
employer.  In  addition  Mr.  de  Bruin  remains  eligible  for a  discretionary
performance  bonus of up to 50 percent of his base  salary  which will be within
the sole  discretion of the Committee and will be based on his  performance  and
his achievement of goals mutually agreed upon by the Committee and Mr. de Bruin.
The Committee has not  specified the terms of Mr. de Bruin's  performance  bonus
and has no plans to specify  such terms  until the  Company  achieves a stronger
financial position.  Consistent with competitive practices in 1994, Mr. de Bruin
was also  granted in 1994,  a stock  option to purchase an  aggregate of 500,000
shares of Common Stock as an incentive for future  performance.  This option was
granted at an exercise  price equal to the fair market value of the common stock
on the date of grant and vests on an annual basis over a  seven-year  period and
has a ten-year term. In recognition of Mr. de Bruin's  leadership,  an option to
purchase 10,000 shares of Common Stock was granted in October 1996 and a further
option to purchase  20,000  additional  shares of Common Stock was granted after
the  Company's  April  1997  staff  reduction.  The Board of  Directors  remains
confident in Mr. de Bruin's  leadership  abilities and is pleased and encouraged
by the Company's progress under Mr. de Bruin.


                                             COMPENSATION COMMITTEE

                                             Dr. George B. Rathmann
                                             Mr. Gene I. Miller


<PAGE> 25



Performance Measurement Comparison (1)

The  following  graph  shows total  stockholder  return of the Nasdaq CRSP Total
Return  Index  for  the  Nasdaq  Stock  Market  (U.S.   Companies)   and  Nasdaq
Pharmaceutical  Index beginning on July 31, 1991, and for the Company  beginning
on August 2, 1991, the date on which the Company's Common Stock commenced public
trading:


                            (GRAPH)



- ---------------------------------

(1)   This Section is not "soliciting  material," is not deemed "filed" with the
      SEC  and is not to be  incorporated  by  reference  in any  filing  of the
      Company  under the 1933 Act or the  Exchange  Act  whether  made before or
      after  the date  hereof  and  irrespective  of any  general  incorporation
      language in any such filing.

*     The total  return on  investment  (change  in  year-end  stock  price plus
      reinvested  dividends) assumes $100 invested on August 2, 1991 (or on July
      31, 1991 as indicated on the above index) in Somatogen,  Inc. Common Stock
      (at the initial  public  offering  price of $19.00 per share),  the Nasdaq
      CRSP Total Return Index for Nasdaq  Stock (U.S.  Companies)  Index and the
      Nasdaq Pharmaceutical Index.


<PAGE> 26




OTHER BUSINESS

The Board of Directors  knows of no other  business  that will be presented  for
consideration  at the Annual  Meeting.  If other  matters are  properly  brought
before the meeting, it is the intention of the persons named in the accompanying
proxy to vote the shares represented  thereby on such matters in accordance with
their best judgment.

                                       By Order of the Board of Directors


                                       James C.T. Linfield
                                       Secretary


September 14, 1997

A copy of the Company's Annual Report to the Securities and Exchange  Commission
on Form 10-K for the fiscal year ended June 30, 1997 is available without charge
upon written request to Secretary,  Somatogen,  Inc., 2545 Central Avenue, Suite
FD1, Boulder, Colorado 80301-2857.



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