<PAGE> 1
(LOGO JOHN HANCOCK FUNDS)
________________________________________________________________________________
101 Huntington Avenue
Boston, Massachusetts 02199-7603
December 21, 1995
John Hancock Advisers, Inc.
United States Securities and Exchange Commission
OFICS Filer Support
SEC Operations Center
6432 General Green Way
Alexandria, Virginia. 22312-2413
Re: Rule 24f-2 Notice for
John Hancock Series Inc.
Registration Nos. 33-16048, 811-5254
Account No. 0000819300
CIK: 819300
Dear Gentlemen:
The purpose of this letter is to notify the Commission within two (2)
months of the end of the Registrant's Fiscal Year of the number of
Registrant's shares sold during the last fiscal year which are to be
registered pursuant to Rule 24f-2 and to pay the appropriate registration
fee.
The information required by the above referenced rule is as follows:
Fiscal Year: November 1, 1994 to October 31, 1995
<TABLE>
<S> <C>
Number of Shares previously
Registered Other than
Pursuant to Rule 24f-2
Remaining Unsold at
Beginning of Fiscal Year: 0
Number of Shares registered
During Fiscal Year other than
Pursuant to Rule 24f-2: 0
Number of Shares Sold During
Fiscal Year: 358,366,411
Number of Shares previously
Registered Other than
Pursuant to Rule 24f-2
Remaining Unsold at
End of Fiscal Year: 0
Number of Shares Reinvested During
Fiscal Year: 4,456,905
</TABLE>
______________________________________________________________ JOHN HANCOCK(R)
John Hancock Advisers, Inc. - John Hancock Funds, Inc.* - FINANCIAL SERVICES
John Hancock Investor Services Corporation - John Hancock
Advisers International, Ltd. - NM Capital Management, Inc. -
Sovereign Asset Management Corporation
*Member of National Association of Securities Dealers, Inc.
<PAGE> 2
United States Securities and Exchange Commission
John Hancock Series Inc.
December 21, 1995
Page Two
Number of Shares Sold During
Fiscal Year Pursuant to
Rule 24f-2: 362,823,316
Attached to this Rule 24f-2 Notice, and made part hereof, is an opinion of
counsel indicating that the Securities, the Registration of which the notice
makes definite in number, were legally issued, fully paid and non-assessable by
the Registrant.
In accordance with subsection (c) of Rule 24f-2, a registration fee for John
Hancock Series, Inc. of $165,674 is due to the Securities and Exchange
Commission. The fee computation is based upon the following:
<TABLE>
<S> <C>
(1) Aggregate Sales Price of Shares
Sold During the Fiscal Year in Reliance
Upon the 24f-2 Declaration (Based
on aggregate sale price for
all shares sold of $1,320,940,627 less
aggregate sale price of shares
registered pursuant to Rule 24e-2
of None) $1,320,940,627
(2) Aggregate Reinvestment Price
of Shares Reinvested During
the Fiscal Year 24,147,405
Reduced By
(1) Aggregate Redemption Price
of Shares Redeemed During
the Fiscal Year and, (864,634,500)
(2) Aggregate Redemption
Price of Redeemed Shares
Previously Applied by
Fund Pursuant to Rule
24e-2 (a) Filings Made Pursuant
to Section 24(e)(1) of Investment
Company Act of 1940 $ 0
--------------
Net sales applicable for fee $ 480,453,532
Computation of fee / 2900
--------------
Fee $ 165,673.63
--------------
</TABLE>
<PAGE> 3
United States Securities and Exchange Commission
John Hancock Series Inc.
December 21, 1995
Page Three
Any questions regarding this matter should be addressed to William H. King,
Associate Treasurer, John Hancock Advisers, Inc., 101 Huntington Avenue,
8th floor, Boston, MA 02199-7603, (617) 375-1668.
Very truly yours,
/s/ William H. King
-----------------------
William H. King
Associate Treasurer
<PAGE> 4
(LOGO JOHN HANCOCK FUNDS)
________________________________________________________________________________
101 Huntington Avenue
Boston, Massachusetts 02199-7603
John Hancock Advisers, Inc.
December 21, 1995
John Hancock Series, Inc.
101 Huntington Avenue
Boston, MA 02199
Re: Rule 24f-2 Notice for John Hancock Series, Inc.
(File Nos. 33-16048; 811-5254) (0000819300)
Ladies and Gentlemen:
In connection with the filing of a Notice pursuant to Rule 24f-2 under the
Investment Company Act of 1940, as amended, making definite the registration
under the Securities Act of 1933 of 362,823,316 shares of the John Hancock
Series, Inc. (the "Registrant") sold in reliance upon said Rule 24f-2 during
the fiscal year ended October 31, 1995, it is the opinion of the undersigned
that such shares were legally issued, fully paid and nonassessable.
Sincerely,
JOHN HANCOCK ADVISERS, INC.
/s/ Alfred P. Ouellette
--------------------------------
Alfred P. Ouellette
Assistant Secretary
Member of Massachusetts and New Hampshire Bars
_____________________________________________________________ JOHN HANCOCK(R)
John Hancock Advisers, Inc. - John Hancock Funds, Inc.* - FINANCIAL SERVICES
John Hancock Investor Services Corporation - John Hancock
Advisers International, Ltd. - NM Capital Management, Inc. -
Sovereign Asset Management Corporation
*Member of National Association of Securities Dealers, Inc.
