HANCOCK JOHN SERIES INC
24F-2NT, 1996-10-29
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 24F-2
                        Annual Notice of Securities Sold
                             Pursuant to Rule 24f-2

            Read instructions at end of Form before preparing Form.
                             Please print or type.

- --------------------------------------------------------------------------------
1.   Name and address of issuer:

          John Hancock Series Inc.

- --------------------------------------------------------------------------------
2.   Name of each series or class of funds for which this notice is filed:

          John Hancock High Yield Tax-Free Fund

- --------------------------------------------------------------------------------
3.   Investment Company Act File Number:

          811-5254

     Securities Act File Number:

          33-16048

- --------------------------------------------------------------------------------
4.   Last day of fiscal year for which this notice is filed

          August 31, 1996

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5.   Check box if this notice is being filed more than 180 days after the close
     of the issuer's fiscal year for purposes of reporting securities sold after
     the close of the fiscal year but before termination of the issuer's 24f-2
     declaration:

                                                  [  ]

- --------------------------------------------------------------------------------
6.   Date of termination of issuer's declaration under rule 24f-2 (a)(1), if
     applicable (see Instruction A.6):

          N/A

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7.   Number and amount of securities of the same class or series which had been
     registered under the Securities Act of 1933 other than pursuant to rule
     24f-2 in a prior fiscal year, but which remained unsold at the beginning of
     the fiscal year:

                     0 shares
          $          0

- --------------------------------------------------------------------------------
8.   Number and amount of securities registered during the fiscal year other
     than pursuant to rule 24f-2:

                     0 shares
          $          0

- --------------------------------------------------------------------------------
9.   Number and aggregate sales price of securities sold during the fiscal year:

             3,529,868 shares
          $ 33,369,896

- --------------------------------------------------------------------------------
10.  Number and aggregate sales price of securities sold during the fiscal year
     in reliance upon registration pursuant to rule 24f-2:

             3,529,868 shares
          $ 33,369,896

- --------------------------------------------------------------------------------


                                   Page 1 of 2
<PAGE>

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11.  Number and aggregate sales price of securities issued during the fiscal
     year in connection with dividend reinvestment plans, if applicable (see
     Instruction B.7):

               309,610 shares
          $  2,906,344

- --------------------------------------------------------------------------------
12.  Calculation of registration fee:

     (i)    Aggregate sale price of securities sold during the 
            fiscal year in reliance on rule 24f-2 
            (from Item 10):                                        $  33,369,896
                                                                   -------------

     (ii)   Aggregate price of shares issued in connection 
            with dividend reinvestment plans (from Item 11,
            if applicable):                                        +   2,906,344
                                                                   -------------

     (iii)  Aggregate price of shares redeemed or repurchased 
            during the fiscal year (if applicable):                -  28,612,244
                                                                   -------------

     (iv)   Aggregate price of shares redeemed or repurchased 
            and previously applied as a reduction to filing 
            fees pursuant to rule 24e-2 (if applicable):           +           0
                                                                   -------------

     (v)    Net aggregate price of securities sold and issued 
            during the fiscal year in reliance on rule 24f-2 
            [line (i), plus line (ii), less line (iii), 
            plus line (iv)] (if applicable):                           7,663,996
                                                                   -------------

     (vi)   Multiplier prescribed by Section 6(b) of the 
            Securities Act of 1933 or other applicable law 
            or regulation (see Instruction C.6):                   x      1/3300
                                                                   -------------

     (vii)  Fee due [line (i) or line (v) multiplied by 
            line(vi)]:                                             $       2,322
                                                                   =============

Instruction: Issuers should complete lines (ii), (iii), (iv) and (v) only if the
             form is being filed within 60 days after the close of the issuer's 
             fiscal year.                              See Instruction C.3.

- --------------------------------------------------------------------------------

13.  Check box if fees are being remitted to the Commission's lockbox depository
     as described in section 3a of the Commission's Rules of Informal and Other
     Procedures (17 CFR 202.3a).

                                                  [X]

     Date of mailing or wire transfer of filing fees to the Commission's lockbox
     depository:

     October 24, 1996
- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------
                                   SIGNATURES

     This report has been signed below by the following persons on behalf of the
     issuer and in the capacities and on the dates indicated:

     By (Signature and Title)*  /s/ Paul L. Aries
                                -------------------------------------------
                                Paul L. Aries        Assistant Treasurer
                                -------------------------------------------

     Date: October 29, 1996

  * Please print the name and title of the signing officer below the signature.

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                                  Page 2 of 2


October 25, 1996


John Hancock Series, Inc.
101 Huntington Avenue
Boston, MA  02199

Re:  Rule 24f-2 Notice for John Hancock Series, Inc.
     for John Hancock High Yield Tax-Free Fund
     (File Nos. 33-16048; 811-5754) (0000819300)

Ladies and Gentlemen:

In connection with the filing of a Notice pursuant to Rule 24f-2 under the
Investment Company Act of 1940, as amended, making definite the registration
under the Securities Act of 1933 of 3,529,868 shares of the John Hancock High
Yield Tax-Free Fund series of John Hancock Series, Inc. sold in reliance upon
said Rule 24f-2 during the fiscal year ended August 31, 1996, it is the opinion
of the undersigned that such shares were legally issued, fully paid and
nonassessable.

Sincerely,

JOHN HANCOCK ADVISERS, INC.

/s/ Theresa Apruzzese

Theresa Apruzzese
Assistant Secretary
Member of Massachusetts Bar



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