<PAGE> PAGE 1
000 A000000 06/30/99
000 C000000 819930
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 3.0.a
000 J000000 U
001 A000000 T. ROWE PRICE SCIENCE & TECHNOLOGY FUND, INC.
001 B000000 811-5299
001 C000000 4103452000
002 A000000 100 EAST PRATT STREET
002 B000000 BALTIMORE
002 C000000 MD
002 D010000 21202
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
007 C010200 2
007 C010300 3
007 C010400 4
007 C010500 5
007 C010600 6
007 C010700 7
007 C010800 8
007 C010900 9
007 C011000 10
008 A000001 T. ROWE PRICE ASSOCIATES, INC.
008 B000001 A
008 C000001 801-856
008 D010001 BALTIMORE
008 D020001 MD
008 D030001 21202
011 A000001 T. ROWE PRICE INVESTMENT SERVICES, INC.
011 B000001 8-25130
011 C010001 BALTIMORE
011 C020001 MD
011 C030001 21202
012 A000001 T. ROWE PRICE SERVICES, INC.
012 B000001 84-1079
012 C010001 BALTIMORE
012 C020001 MD
012 C030001 21202
013 A000001 PRICEWATERHOUSECOOPERS LLP
013 B010001 BALTIMORE
013 B020001 MD
<PAGE> PAGE 2
013 B030001 21202
014 A000001 T. ROWE PRICE INVESTMENT SERVICES, INC.
014 B000001 8-25130
015 A000001 STATE STREET BANK AND TRUST COMPANY
015 B000001 C
015 C010001 BOSTON
015 C020001 MA
015 C030001 02101
015 E010001 X
018 000000 Y
019 A000000 Y
019 B000000 88
019 C000000 TROWEPRICE
020 A000001 GOLDMAN SACHS
020 B000001 13-5108880
020 C000001 259
020 A000002 MORGAN STANLEY
020 B000002 13-2655998
020 C000002 234
020 A000003 SALOMON SMITH BARNEY
020 B000003 11-2418191
020 C000003 192
020 A000004 INSTINET
020 B000004 13-3443395
020 C000004 186
020 A000005 BEAR STEARNS
020 B000005 13-3299429
020 C000005 181
020 A000006 DONALDSON LUFKIN & JENRETTE
020 B000006 13-2741729
020 C000006 161
020 A000007 MERRILL LYNCH
020 B000007 13-5674085
020 C000007 138
020 A000008 DRESDNER KLEINWORTH BENSON
020 B000008 13-3894311
020 C000008 131
020 A000009 C.S. FIRST BOSTON
020 B000009 13-5659485
020 C000009 110
020 A000010 AUTRANET
020 B000010 13-2961507
020 C000010 103
021 000000 3139
022 A000001 MORGAN STANLEY
022 B000001 13-2655998
022 C000001 396555
022 D000001 337289
022 A000002 C.S. FIRST BOSTON
022 B000002 13-5659485
022 C000002 240058
<PAGE> PAGE 3
022 D000002 351734
022 A000003 GOLDMAN SACHS
022 B000003 13-5108880
022 C000003 344683
022 D000003 233509
022 A000004 MERRILL LYNCH
022 B000004 13-5674085
022 C000004 325911
022 D000004 212454
022 A000005 SALOMON SMITH BARNEY
022 B000005 11-2418191
022 C000005 326158
022 D000005 154147
022 A000006 DONALDSON LUFKIN & JENRETTE
022 B000006 13-2741729
022 C000006 190152
022 D000006 155372
022 A000007 DEUTSCHE BANK SECURITIES
022 B000007 13-2730828
022 C000007 84701
022 D000007 88161
022 A000008 LEHMAN BROTHERS
022 B000008 13-2518466
022 C000008 115379
022 D000008 52064
022 A000009 J.P. MORGAN
022 B000009 13-3224016
022 C000009 60599
022 D000009 103751
022 A000010 PAINE WEBBER
022 B000010 13-2638166
022 C000010 123725
022 D000010 28081
023 C000000 2837139
023 D000000 2496658
024 000000 N
025 D000001 0
025 D000002 0
025 D000003 0
025 D000004 0
025 D000005 0
025 D000006 0
025 D000007 0
025 D000008 0
026 A000000 N
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
<PAGE> PAGE 4
026 G020000 N
026 H000000 Y
027 000000 Y
028 A010000 303140
028 A020000 0
028 A030000 0
028 A040000 178328
028 B010000 252250
028 B020000 0
028 B030000 0
028 B040000 141729
028 C010000 212944
028 C020000 0
028 C030000 0
028 C040000 153308
028 D010000 308946
028 D020000 0
028 D030000 0
028 D040000 153619
028 E010000 188905
028 E020000 0
028 E030000 0
028 E040000 107433
028 F010000 191175
028 F020000 0
028 F030000 0
028 F040000 99082
028 G010000 1457360
028 G020000 0
028 G030000 0
028 G040000 833499
028 H000000 0
029 000000 N
030 A000000 0
030 B000000 0.00
030 C000000 0.00
031 A000000 0
031 B000000 0
032 000000 0
033 000000 0
034 000000 N
035 000000 0
036 B000000 0
037 000000 N
038 000000 0
039 000000 N
040 000000 N
042 A000000 0
042 B000000 0
042 C000000 0
042 D000000 0
<PAGE> PAGE 5
042 E000000 0
042 F000000 0
042 G000000 0
042 H000000 0
043 000000 0
044 000000 0
045 000000 Y
046 000000 N
047 000000 N
048 000000 0.000
048 A010000 0
048 A020000 0.000
048 B010000 0
048 B020000 0.000
048 C010000 0
048 C020000 0.000
048 D010000 0
048 D020000 0.000
048 E010000 0
048 E020000 0.000
048 F010000 0
048 F020000 0.000
048 G010000 0
048 G020000 0.000
048 H010000 0
048 H020000 0.000
048 I010000 0
048 I020000 0.000
048 J010000 0
048 J020000 0.000
048 K010000 0
048 K020000 0.000
049 000000 N
050 000000 N
051 000000 N
052 000000 Y
053 A000000 N
054 A000000 Y
054 B000000 N
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
<PAGE> PAGE 6
054 O000000 Y
055 A000000 N
055 B000000 N
056 000000 Y
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 Y
060 B000000 Y
061 000000 2500
062 A000000 N
062 B000000 0.0
062 C000000 0.0
062 D000000 0.0
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 0.0
062 P000000 0.0
062 Q000000 0.0
062 R000000 0.0
063 A000000 0
063 B000000 0.0
066 A000000 Y
066 B000000 N
066 C000000 N
066 D000000 Y
066 E000000 N
066 F000000 N
066 G000000 N
067 000000 N
068 A000000 N
068 B000000 N
069 000000 N
070 A010000 Y
070 A020000 N
070 B010000 Y
070 B020000 N
070 C010000 N
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 N
070 E020000 N
<PAGE> PAGE 7
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 N
070 K010000 Y
070 K020000 Y
070 L010000 Y
070 L020000 Y
070 M010000 Y
070 M020000 Y
070 N010000 Y
070 N020000 N
070 O010000 Y
070 O020000 N
070 P010000 Y
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 N
070 R020000 N
071 A000000 4484495
071 B000000 4034270
071 C000000 5120579
071 D000000 79
072 A000000 6
072 B000000 12767
072 C000000 2448
072 D000000 0
072 E000000 0
072 F000000 18539
072 G000000 0
072 H000000 0
072 I000000 5794
072 J000000 77
072 K000000 87
072 L000000 247
072 M000000 9
072 N000000 171
072 O000000 0
072 P000000 0
072 Q000000 39
072 R000000 9
072 S000000 1
072 T000000 0
072 U000000 0
<PAGE> PAGE 8
072 V000000 0
072 W000000 31
072 X000000 25004
072 Y000000 0
072 Z000000 -9789
072AA000000 1095639
072BB000000 0
072CC010000 463303
072CC020000 0
072DD010000 0
072DD020000 0
072EE000000 0
073 A010000 0.0000
073 A020000 0.0000
073 B000000 0.0000
073 C000000 0.0000
074 A000000 0
074 B000000 0
074 C000000 321056
074 D000000 0
074 E000000 0
074 F000000 6610316
074 G000000 0
074 H000000 0
074 I000000 0
074 J000000 11728
074 K000000 0
074 L000000 22295
074 M000000 0
074 N000000 6965395
074 O000000 77975
074 P000000 887
074 Q000000 0
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 16966
074 S000000 0
074 T000000 6869567
074 U010000 139401
074 U020000 0
074 V010000 49.28
074 V020000 0.00
074 W000000 0.0000
074 X000000 257611
074 Y000000 0
075 A000000 0
075 B000000 5591020
076 000000 0.00
077 A000000 N
078 000000 N
<PAGE> PAGE 9
SIGNATURE HENRY H. HOPKINS
TITLE VICE PRESIDENT
WARNING: THE EDGAR SYSTEM ENCOUNTERED ERROR(S) WHILE PROCESSING THIS SCHEDULE.
<TABLE> <S> <C>
<ARTICLE> 6
<CIK> 0000819930
<NAME> T. ROWE PRICE SCIENCE & TECHNOLOGY FUND
<S> <C>
<PERIOD-TYPE> 6-MOS
<FISCAL-YEAR-END> DEC-31-1999
<PERIOD-END> JUN-30-1999
<INVESTMENTS-AT-COST> 4893586
<INVESTMENTS-AT-VALUE> 6931372
<RECEIVABLES> 34023
<ASSETS-OTHER> 0
<OTHER-ITEMS-ASSETS> 0
<TOTAL-ASSETS> 6965395
<PAYABLE-FOR-SECURITIES> 77975
<SENIOR-LONG-TERM-DEBT> 0
<OTHER-ITEMS-LIABILITIES> 17853
<TOTAL-LIABILITIES> 95828
<SENIOR-EQUITY> 0
<PAID-IN-CAPITAL-COMMON> 3695178
<SHARES-COMMON-STOCK> 139401
<SHARES-COMMON-PRIOR> 124640
<ACCUMULATED-NII-CURRENT> 0
<OVERDISTRIBUTION-NII> 9789
<ACCUMULATED-NET-GAINS> 1146394
<OVERDISTRIBUTION-GAINS> 0
<ACCUM-APPREC-OR-DEPREC> 2037784
<NET-ASSETS> 6869567
<DIVIDEND-INCOME> 2448
<INTEREST-INCOME> 12767
<OTHER-INCOME> 0
<EXPENSES-NET> 25004
<NET-INVESTMENT-INCOME> (9789)
<REALIZED-GAINS-CURRENT> 1095639
<APPREC-INCREASE-CURRENT> 463303
<NET-CHANGE-FROM-OPS> 1549153
<EQUALIZATION> 0
<DISTRIBUTIONS-OF-INCOME> 0
<DISTRIBUTIONS-OF-GAINS> 0
<DISTRIBUTIONS-OTHER> 0
<NUMBER-OF-SHARES-SOLD> 34736
<NUMBER-OF-SHARES-REDEEMED> (19975)
<SHARES-REINVESTED> 0
<NET-CHANGE-IN-ASSETS> 2174014
<ACCUMULATED-NII-PRIOR> 0
<ACCUMULATED-GAINS-PRIOR> 50755
<OVERDISTRIB-NII-PRIOR> 0
<OVERDIST-NET-GAINS-PRIOR> 0
<GROSS-ADVISORY-FEES> 18539
<INTEREST-EXPENSE> 0
<GROSS-EXPENSE> 25016
<AVERAGE-NET-ASSETS> 5591020
<PER-SHARE-NAV-BEGIN> 37.67
<PER-SHARE-NII> (0.07)
<PER-SHARE-GAIN-APPREC> 11.68
<PER-SHARE-DIVIDEND> 0
<PER-SHARE-DISTRIBUTIONS> 0
<RETURNS-OF-CAPITAL> 0
<PER-SHARE-NAV-END> 49.28
<EXPENSE-RATIO> 0.9
[AVG-DEBT-OUTSTANDING] 0
[AVG-DEBT-PER-SHARE] 0
</TABLE>
