AFEM MEDICAL CORP
S-8, 2000-05-10
CONVERTED PAPER & PAPERBOARD PRODS (NO CONTANERS/BOXES)
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<PAGE>   1
       AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 10, 2000
                                                      REGISTRATION NO.    -_____
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                             ----------------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                             ----------------------

                            A-FEM MEDICAL CORPORATION
                     (FORMERLY, ATHENA MEDICAL CORPORATION)
             (Exact name of Registrant as specified in its charter)

                 NEVADA                                33-0202574
    (State or other jurisdiction of                 (I.R.S. Employer
     incorporation or organization)                Identification No.)


                        10180 S.W. NIMBUS AVE., SUITE J5
                             PORTLAND, OREGON 97223
          (Address of Principal Executive Offices, including zip code)

                           ATHENA MEDICAL CORPORATION
         1994 INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN, AS AMENDED

                            A-FEM MEDICAL CORPORATION
                   NON-QUALIFIED STOCK OPTION LETTER AGREEMENT
                            (Full title of the plans)

                                STEVEN T. FRANKEL
                            A-FEM MEDICAL CORPORATION
                        10180 S.W. NIMBUS AVE., SUITE J5
                             PORTLAND, OREGON 97223
                                 (503) 968-8800
 (Name, address and telephone number, including area code, of agent for service)
                             ----------------------
                                    COPY TO:
                               PATRICK J. SIMPSON
                                DANIELLE BENDERLY
                                PERKINS COIE LLP
                       1211 S.W. FIFTH AVENUE, SUITE 1500
                           PORTLAND, OREGON 97204-3715
                             ----------------------

                         CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
                                              PROPOSED MAXIMUM       PROPOSED MAXIMUM       AMOUNT OF
   TITLE OF SECURITIES      AMOUNT TO BE     OFFERING PRICE PER     AGGREGATE OFFERING    REGISTRATION
     TO BE REGISTERED       REGISTERED(1)         SHARE(2)               PRICE(2)              FEE
   -------------------      -------------    ------------------     ------------------    ------------
<S>                         <C>              <C>                    <C>                   <C>
Common Stock, no par
  value per share:

  Athena Medical
    Corporation, 1994       3,300,000                  $2.00             $6,600,000          $1,742.40
    Incentive and
    Non-Qualified Stock
    Option Plan

  A-Fem Medical
    Corporation             1,700,000                  $2.06             $3,502,000            $924.53
    Non-Qualified Stock
    Option Letter
    Agreement
                            ---------                                   -----------          ---------
    Total:                  5,000,000                                   $10,102,000          $2,666.93
                            =========                                   ===========          =========
</TABLE>

(1)  Together with an indeterminate number of additional shares that may be
     necessary to adjust the number of shares reserved for issuance under the
     Athena Medical Corporation 1994 Incentive and Non-Qualified Stock Option
     Plan, and the A-Fem Medical Corporation Non-Qualified Stock Option Letter
     Agreement as the result of any future stock split, stock dividend or
     similar adjustment of the outstanding Common Stock of the Registrant.

(2)  Estimated pursuant to Rule 457(c) under the Securities Act of 1933, as
     amended, solely for the purpose of calculating the registration fee. The
     price per share under the Athena Medical Corporation 1994 Incentive and
     Non-Qualified Stock Option Plan is estimated to be $2.00 based on the
     average of the high and low bid prices reported for the Common Stock on the
     OTC Bulletin Board on May 8, 2000. The price per share under the A-Fem
     Medical Corporation Non-Qualified Stock Option Letter Agreement is $2.06
     based on the exercise price per share under this Plan.


<PAGE>   2


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE

        The following documents are hereby incorporated by reference in this
Registration Statement:

                (a) The Registrant's Annual Report on Form 10-KSB for the fiscal
year ended December 31, 1999 filed with the Securities and Exchange Commission
(the "Commission") on March 30, 2000;

                (b) All other reports filed by the Registrant pursuant to
Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the
"Exchange Act"), since the end of the fiscal year covered by the Form 10-KSB
referred to in (a) above; and

                (c) The description of the Registrant's Common Stock contained
in the Registration Statement on Form S-2 filed with the Commission on May 12,
1999 under Section 12(g) of the Exchange Act.

        All documents filed by the Registrant pursuant to Sections 13(a), 13(c),
14 and 15(d) of the Exchange Act after the date hereof and prior to the filing
of a post-effective amendment that indicates that the securities offered hereby
have been sold or that deregisters the securities covered hereby then remaining
unsold, shall also be deemed to be incorporated by reference into this
Registration Statement and to be a part hereof commencing on the respective
dates on which such documents are filed.

ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS

        The Nevada corporation law provides that a company may indemnify its
officers, directors and employees for liability arising out of certain actions.
The Registrant has included in its Articles of Incorporation and Bylaws
provisions to indemnify its directors and officers to the fullest extent
permitted by Nevada General Corporation Law. Such indemnification may be
available for liabilities arising in connection with this offering. Insofar as
indemnification for liabilities arising under the Securities Act may be
permitted to directors, officers or persons controlling the Registrant pursuant
to such indemnification provisions, the Registrant has been advised that in the
opinion of the Securities and Exchange Commission such indemnification is
against public policy as expressed in the Act and is therefore unenforceable.

        The Registrant has adopted in its Articles of Incorporation a provision
that limits personal liability for breach of the fiduciary duty of its
directors, to the extent provided by Section 78.037 of the Nevada General
Corporation Law. Such provision eliminates the personal liability of directors
for damages occasioned by breach of fiduciary duty, except for liability based
on the director's duty of loyalty to the Registrant, liability for acts or
omissions involving intentional misconduct, fraud or a knowing violation of law,
liability based on payments of improper dividends, and liability for acts
occurring prior to the date such provision was added.

ITEM 8. EXHIBITS

<TABLE>
<CAPTION>
    EXHIBIT
     NUMBER                                        DESCRIPTION
    -------                                        -----------
<S>               <C>
      5.1         Opinion of Perkins Coie LLP regarding legality of the Common Stock being registered

     23.1         Consent of Arthur Andersen LLP

     23.2         Consent of Perkins Coie LLP (included in the opinion filed as Exhibit 5.1)

     99.1         Athena Medical Corporation 1994 Incentive and Non-Qualified Stock Option Plan(1)
</TABLE>


                                      II-1
<PAGE>   3

<TABLE>
<S>               <C>
     99.2         A-Fem Medical Corporation Non-Qualified Stock Option Letter Agreement
</TABLE>

- -----------

(1)  Incorporated by reference to the exhibits to the Registrant's Annual Report
     on Form 10-KSB for the year ended December 31, 1996.

ITEM 9. UNDERTAKINGS

A. The undersigned Registrant hereby undertakes:

        (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement:

                (i) to include any prospectus required by Section 10(a)(3) of
the Securities Act of 1933, as amended (the "Securities Act");

                (ii) to reflect in the prospectus any facts or events arising
after the effective date of this Registration Statement (or the most recent
post-effective amendment thereof) that, individually or in the aggregate,
represent a fundamental change in the information set forth in this Registration
Statement; and

                (iii) to include any material information with respect to the
plan of distribution not previously disclosed in this Registration Statement or
any material change to such information in this Registration Statement;

provided, however, that paragraphs (1)(i) and (1)(ii) above do not apply if the
information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed by the Registrant pursuant to
Section 13 or Section 15(d) of the Exchange Act that are incorporated by
reference in this Registration Statement.

        (2) That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

        (3) To remove from registration by means of a post-effective amendment
any of the securities being registered that remain unsold at the termination of
the offering.

B. The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934, as amended (the "Exchange Act") (and, where
applicable, each filing of an employee benefits plan's annual report pursuant to
Section 15(d) of the Exchange Act) that is incorporated by reference in this
Registration Statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

C. Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Commission such indemnification is
against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or
paid by a director, officer or controlling person of the Registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final
adjudication of such issue.


                                      II-2
<PAGE>   4

                                   SIGNATURES

        Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Portland, State of Oregon, on May 10, 2000.

                                        A-FEM MEDICAL CORPORATION

                                        By: /s/ Steven T. Frankel
                                           ---------------------------------
                                           Steven T. Frankel
                                           President and Chief Executive Officer

                                POWER OF ATTORNEY

        Each person whose individual signature appears below hereby authorizes
and appoints William H. Fleming and Steven T. Frankel, and each of them, with
full power of substitution and resubstitution and full power to act without the
other, as his true and lawful attorney-in-fact and agent to act in his name,
place and stead and to execute in the name and on behalf of each person,
individually and in each capacity stated below, and to file any and all
amendments to this Registration Statement, including any and all post-effective
amendments and amendments thereto, and to file the same, with all exhibits
thereto, and other documents in connection therewith, with the Securities and
Exchange Commission, granting unto said attorneys-in-fact and agents, and each
of them, full power and authority to do and perform each and every act and
thing, ratifying and confirming all that said attorneys-in-fact and agents or
any of them or their and his substitute or substitutes, may lawfully do or cause
to be done by virtue thereof.

        Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed by the following persons in the
capacities indicated on May 10, 2000.

<TABLE>
<CAPTION>
              Signature                                        Title
              ---------                                        -----
<S>                                                <C>
   /s/ William H. Fleming                           Vice Chairman and Secretary
- -----------------------------------
          William H. Fleming

   /s/ James E. Reinmuth                            Chairman and Director
- -----------------------------------
          James E. Reinmuth

   /s/ Steven T. Frankel                            President and Chief Executive Officer
- -----------------------------------                 (principal executive officer)
          Steven T. Frankel

   /s/ James R. Wilson                              Director and Treasurer
- -----------------------------------                 (principal financial officer)
           James R. Wilson

   /s/ Carol A. Scott                               Director
- -----------------------------------
            Carol A. Scott

   /s/ RoseAnna Sevcik                              Director
- -----------------------------------
           RoseAnna Sevcik

   /s/ Merry Disney                                 Director
- -----------------------------------
             Merry Disney

   /s/ Martin L. Harvey                             Controller
- -----------------------------------                 (principal accounting officer)
           Martin L. Harvey
</TABLE>


                                      II-3
<PAGE>   5

                                INDEX TO EXHIBITS

<TABLE>
<CAPTION>
    EXHIBIT                                                                   SEQUENTIALLY
     NUMBER                             DESCRIPTION                          NUMBERED PAGE
     ------                             -----------                          -------------
<S>               <C>
      5.1         Opinion of Perkins Coie LLP regarding legality of the
                  Common Stock being registered

     23.1         Consent of Arthur Andersen LLP

     23.2         Consent of Perkins Coie (included in the opinion filed
                  as Exhibit 5.1)

     99.1         Athena Medical Corporation 1994 Incentive and
                  Non-Qualified Stock Option Plan(1)

     99.2         A-Fem Medical Corporation Non-Qualified Stock Option
                  Letter Agreement
</TABLE>

(1)  Incorporated by reference to the exhibits to the Registrant's Annual Report
     on Form 10-KSB for the year ended December 31, 1996.


<PAGE>   1


                                                                     Exhibit 5.1


                                PERKINS COIE LLP
              A LAW PARTNERSHIP INCLUDING PROFESSIONAL CORPORATIONS
      1211 SOUTHWEST FIFTH AVENUE, SUITE 1500 X PORTLAND, OREGON 97204-3715
                TELEPHONE: 503 727-2000 X FACSIMILE: 503 727-2222

                                                                     May 9, 2000


A-Fem Medical Corporation
10180 SW Nimbus Avenue
Suite J-5
Portland, Oregon  97223

        RE: 5,000,000 SHARES OF COMMON STOCK $.01 OF A-FEM MEDICAL CORPORATION.
            (THE "COMPANY")

Ladies and Gentlemen:

        We have acted as counsel to the Company in connection with the
preparation of a Registration Statement on Form S-8 (the "Registration
Statement") under the Securities Act of 1933, as amended (the "Act"), to be
filed with the Securities and Exchange Commission with respect to an aggregate
of 5,000,000 shares of Common Stock, $.01 par value of the Company (the
"Shares"), that may be issued pursuant to Athena Medical Corporation 1994
Incentive and Non-Qualified Stock Option Plan and the A-Fem Non-Qualified Stock
Option Letter Agreement (together, the "Plans"). We have examined the
Registration Statement and such documents and records of the Company and other
documents as we have deemed necessary for the purpose of this opinion.

        We are of the opinion that the Shares that will be issued upon the
exercise of stock options granted pursuant to the Plans have been duly
authorized and that, upon the receipt of the consideration therefor in
accordance with the terms of the Plans and issuance thereof by the Company, the
Shares will be validly issued, fully paid and nonassessable.

        We hereby consent to the filing of this opinion as Exhibit 5.1 to the
Registration Statement. In giving such consent, we do not admit that we are in
the category of persons whose consent is required under Section 7 of the Act.

                                            Very truly yours,



                                            /s/ PERKINS COIE LLP


<PAGE>   1


                                  EXHIBIT 23.1

                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS



        As independent public accountants, we hereby consent to the
incorporation by reference in this Registration Statement on Form S-8, of our
report dated February 25, 2000, included in A-Fem Medical Corporation's Form
10-KSB for the year ended December 31, 1999, and to all references to our Firm
included in this Registration Statement.

                                            /s/ Arthur Andersen LLP
                                            ------------------------------------



- ----------------
Portland, Oregon
May 9, 2000

<PAGE>   1
                            A-FEM MEDICAL CORPORATION

                   NON-QUALIFIED STOCK OPTION LETTER AGREEMENT


To: Steven Frankel

        The Board of Directors of A-Fem Medical Corporation (the "Company") has
awarded you stock options for the purchase of 1,700,000 shares of the Company's
common stock at an exercise price of $2.06 per share subject to the vesting
schedule set forth below.

1. TERM: The term of the option is ten years from date of grant, unless sooner
terminated.

2. EXERCISE: During your lifetime only you can exercise the option: The personal
representative of your estate or the beneficiary thereof may exercise the option
following your death. To exercise your option, you must deliver to the Company
written notice of your intention to exercise, specifying the number of shares as
to which you desire to exercise the option and the date on which you desire to
complete the transaction, and if required in order to comply with the Securities
Act of 1933, as amended, such written notice must contain a representation that
it is your present intention to acquire the shares for investment and not with a
view to distribution. Unless the Board of Directors determines otherwise, on or
before the date specified for completion of the purchase of shares pursuant to
your option, you must have paid the Company the full purchase price of such
shares in cash (including, with the consent of the Board of Directors, cash that
may be the proceeds of a loan from the Company) or, with the consent of Board of
Directors, in whole or in part, in Common Stock of the Company valued at fair
market value, registered stock, performance units or other contingent awards
nominated in either stock or cash, promissory notes and other forms of
consideration. No shares shall be issued until full payment for the shares has
been made. With the consent of the Board of Directors, you may request the
Company to apply automatically the shares to be received upon the exercise of a
portion of stock option (even though stock certificates have not yet been
issued) to satisfy the purchase price for additional portions of the option.
After exercise of your option, immediately upon notification of the amount due,
if any, you shall pay to the Company in cash amounts necessary to satisfy any
applicable federal, state and local tax withholding requirements. If additional
withholding is or becomes required beyond any amount deposited before delivery
of the certificates, you shall pay such amount to the Company on demand. If you
fail to pay the amount demanded, the Company may withhold that amount from other
amounts payable by the Company to you, including salary, subject to applicable
law. With the consent of the Board of Directors, you may satisfy this
obligation, in whole or in part, by having the Company withhold amounts due or
by delivering to the Company Common Stock shares



                                      -1-
<PAGE>   2

that would satisfy the withholding amount. You may use the Notice of Exercise of
Stock Option in the form attached to this Agreement when you exercise the
option.

3. PAYMENT FOR SHARES: Unless the Board of Directors at any time determines
otherwise, the option may be exercised by the delivery of cash, personal check,
bank certified or cashier's check.

4. TERMINATION: In the event the employment or service of the Optionee with the
Company or a subsidiary terminates for any reason other than because of death,
the option may be exercised at any time prior to the expiration of three years
from the date of termination of the option. Any option may be exercised only if
and to the extent the Optionee was entitled to exercise the option at the date
of such termination. In the event of the termination of employment or service
because of total disability or death, the option may be exercised at any time
prior to the expiration of one year from the date of termination of employment.
To the extent that the option of any deceased Optionee or of any Optionee whose
employment or service terminates is not exercised within the applicable period,
all further rights to purchase shares pursuant to such option shall cease and
terminate.

5. TRANSFER OF OPTION: The option is not transferable except by will or by the
applicable laws of descent and distribution of the state or county of the
optionee's domicile at the time of death or pursuant to a qualified domestic
relations order as defined under the Internal Revenue Code or Title I of the
Employee Income Security Act of 1974, as amended.

6. VESTING: All options shall vest on the 10th anniversary of the grant date. In
addition, vesting shall accelerate and the option shall vest and become
exercisable earlier according to the following schedule:


<TABLE>
<CAPTION>
                                                                                                                  NUMBER OF SHARES
                                 DATE ON AND AFTER WHICH                                                          FOR WHICH OPTION
                                 OPTIONS ARE EXERCISABLE                                                          IS EXERCISABLE
                                 -----------------------                                                          --------------
<S>                                                                                                                   <C>
         Upon appointment as a Director (May 14, 1998) ......................................................          12,500

         Upon the first anniversary of appointment (May 14, 1999) ...........................................          12,500

         Upon the second anniversary of appointment (May 14, 2000) ..........................................          12,500

         Upon the third anniversary of appointment (May 14, 2001) ...........................................          12,500

         Upon appointment as Chief Executive Officer ........................................................         450,000
</TABLE>





                                      -2-
<PAGE>   3


<TABLE>
<S>                                                                                                                   <C>
         Upon completion of raising $6 million or more in equity capital at $2.00 per share or greater ......          25,000

         Upon gaining listing on a major trading market (NYSE, AMEX, NASDAQ) ................................          25,000

         Upon the signing of an agreement with a strategic partner for the Rapid-Sense
         diagnostic that agrees to distribute the product, invest in A-Fem, or fund product development .....         300,000

         Upon signing a strategic partnership for the inSync miniform that
         provides A-Fem revenue through manufacturing, or a royalty, or an
         association to complete the national roll-out of the miniform, or A-Fem
         achieves 65% or more of the U.S. ACV ...............................................................         600,000

         Upon gaining FDA clearance for the PadKit, or if prior to FDA approval,
         gaining a strategic partnership for the PadKit which provides a $1
         million investment in A-Fem ........................................................................          25,000

         Upon achieving a share closing price of $4.00 per share for at least 30 consecutive market days ....         150,000

         Upon achieving a share closing price of $6.00 per share for at least 30 consecutive market days ....          25,000

         Upon achieving a share closing price of $8.00 per share for at least 30 consecutive market days ....          25,000

         Upon achieving a share closing price of $10.00 per share for at least 30 consecutive market days ...          25,000
</TABLE>

7. HOLDING PERIODS

        7.1 SECURITIES AND EXCHANGE ACT SECTION 16

        Shares of Common Stock obtained upon the exercise of a stock option may
not be sold by a person subject to Section 16 of the Exchange Act until six
months after the date the option was granted.



                                      -3-
<PAGE>   4

        7.2 TAXATION OF STOCK OPTIONS

        Tax advice should be obtained when exercising any option and prior to
the disposition of the shares issued upon the exercise of any option.

8. DATE OF GRANT: The date of grant of the option is April 17, 1998.

9. ACCELERATION IN CERTAIN EVENTS: Notwithstanding any other provisions of this
Agreement, all options outstanding under this Agreement shall immediately become
exercisable in full for the remainder of their terms at any time when any one of
the following events has taken place after the date hereof:

        (a) The stockholders of the Company approve one of the following
("Approved Transactions"):

                (i) Any consolidation, merger or plan of exchange, involving the
        Company ("Merger") pursuant to which Common Stock would be converted
        into cash; or

                (ii) Any sale, lease, exchange or other transfer (in one
        transaction or a series of related transactions) of all or substantially
        all of the assets of the Company or the adoption of any plan or proposal
        for the liquidation or dissolution of the Company; or

        (b) A tender or exchange offer, other than one made by the Company, is
made for Common Stock (or securities convertible into Common Stock) and such
offer results in a portion of those securities being purchased and the offeror
after the consummation of the offer is the beneficial owner (as determined
pursuant to Section 13(d) of the Securities Exchange Act of 1934, as amended),
directly or indirectly, of at least 20 percent of the outstanding Common Stock
(an "Offer"); or

        (c) The Company receives a report on Schedule 13D under the Securities
Exchange Act of 1934, as amended, reporting the beneficial ownership by any
person of 20 percent or more of the Company's outstanding Common Stock, except
that if such receipt shall occur during a tender offer or exchange offer by any
person other than the Company or a wholly owned subsidiary of the Company,
acceleration of exercisability shall not take place until the conclusion of such
offer; or

        (d) During any period of 12 months or less, individuals who at the
beginning of such period constituted a majority of the Board of Directors cease
for any reason to constitute a majority thereof unless the nomination or
election of such new Directors was approved by a vote of at least 2/3 of the
Directors then still in office who were Directors at the beginning of such
period.



                                      -4-
<PAGE>   5

        All options that are accelerated pursuant to this Paragraph 9 shall
terminate upon the dissolution of the Company or upon the consummation of any
Merger pursuant to which Common Stock would be converted to cash. The terms used
in this Paragraph 9 and not defined elsewhere in the Agreement shall have the
same meanings as such terms have in the Exchange Act and the rules and
regulations adopted thereunder.

10. APPROVALS: The obligations of the Company under this Agreement are subject
to the approval of state and federal authorities or agencies with jurisdiction
in the matter. The Company will use its best efforts to take steps required by
state or federal law or applicable regulations, including rules and regulations
of the Securities and Exchange Commission and any stock exchange on which the
Company's shares may then be listed, in connection with the grant of options
pursuant to this Agreement. The foregoing notwithstanding, the Company shall not
be obligated to issue or deliver Common Stock pursuant to this Agreement if such
issuance or delivery would violate applicable state or federal securities laws.

11. EMPLOYMENT AND SERVICE RIGHTS: Nothing in this Agreement shall:

                (i) Confer upon any employee the right to be continued in the
        employment of the Company or any subsidiary or interfere in any way with
        the right of the Company or any subsidiary by whom such employee is
        employed to terminate such employee's employment at any time, for any
        reason, with or without cause, or to decrease such employee's
        compensation or benefits; or

                (ii) Confer upon any person engaged by the Company any right to
        be retained or employed by the Company or to the continuation,
        extension, renewal or modification of any compensation, contract or
        arrangement with or by the Company.

12. RIGHTS AS A STOCKHOLDER: As a holder of an option issued pursuant to this
Agreement, you have no rights as a stockholder with respect to any Common Stock
until the date of issue to you of a stock certificate for such shares. Except as
otherwise expressly provided herein, no adjustment shall be made for dividend or
other rights for which the record date occurs prior to the date such stock
certificate is issued.

        THE COMPANY HAS NO OBLIGATION TO REGISTER THE SHARES THAT WOULD BE
ISSUED UPON THE EXERCISE OF YOUR OPTION, AND IF IT NEVER REGISTERS THE SHARES,
YOU WILL NOT BE ABLE TO EXERCISE THE OPTION UNLESS AN EXEMPTION FROM
REGISTRATION IS AVAILABLE. AT THE PRESENT TIME, EXEMPTIONS FROM REGISTRATION
UNDER FEDERAL AND STATE SECURITIES LAWS ARE VERY LIMITED AND MIGHT BE
UNAVAILABLE TO YOU PRIOR TO THE EXPIRATION OF THE OPTION. CONSEQUENTLY, YOU
MIGHT HAVE NO OPPORTUNITY TO



                                      -5-
<PAGE>   6

EXERCISE THE OPTION AND TO RECEIVE SHARES UPON SUCH EXERCISE.

        Please execute the Acceptance and Acknowledgment set forth below on the
enclosed copy of this Agreement and return it to the undersigned.



                                                Very truly yours,

                                                A-FEM MEDICAL CORPORATION


                                                By:
                                                Name:
                                                Its:




                                      -6-
<PAGE>   7

                          ACCEPTANCE AND ACKNOWLEDGMENT


        I, a resident of the State of ____________, accept the stock option
described above, and acknowledge receipt of a copy of this Agreement. I have
read and understand this Agreement. I acknowledge that, except as set forth in
this Agreement, the Company has no obligation to sell or otherwise issue to me
any stock or other equity or ownership interest in the Company.


Dated: _______________



______________________________                  _______________________________
Taxpayer I.D. Number                            Steven Frankel



                                                Address:


        By his or her signature below, the spouse of the Optionee, if such
Optionee is legally married as of the date of his or her execution of this
Agreement, acknowledges that he or she has read this Agreement and is familiar
with the terms and provisions thereof, and agrees to be bound by all the terms
and conditions of this Agreement.

        Dated: _______________



                                                _______________________________
                                                Spouse's Signature


                                                _______________________________
                                                Printed Name


        By his or her signature below, the Optionee represents that he or she is
not legally married as of the date of execution of this Agreement.

        Dated: _______________



                                                _______________________________
                                                Optionee's Signature



                                      -7-
<PAGE>   8

                       NOTICE OF EXERCISE OF STOCK OPTION


To: A-Fem Medical Corporation Board of Directors

        I, a resident of the State of _______________, hereby exercise my stock
option granted by A-Fem Medical Corporation (the "Company") on April 17, 1998,
subject to all the terms and provisions thereof, and notify the Company of my
desire to purchase _______ shares of Common Stock of the Company (the
"Securities") at the exercise price of $2.06 per share which were offered to me
pursuant to said option.

        I hereby represent and warrant that (1) I have been furnished with a
copy of all information which I deem necessary to evaluate the merits and risks
of the purchase of the Securities; (2) I have had the opportunity to ask
questions and receive answers concerning the information received about the
Securities and the Company; and (3) I have been given the opportunity to obtain
any additional information I deem necessary to verify the accuracy of any
information obtained concerning the Securities and the Company.

        I am aware that the Securities have not been registered under the
Federal Securities Act of 1933, as amended (the "Act") or any state securities
laws, pursuant to exemption(s) from registration. I understand that the reliance
by the Company on such exemption(s) is predicated in part upon the truth and
accuracy of the statements by me in this Notice of Exercise.

        I hereby represent and warrant that I am purchasing the Securities for
my own personal account for investment and not with a view to the sale or
distribution of all or any part of the Securities.

        I understand that because the Securities have not been registered under
the Act, I must continue to bear the economic risk of the investment for an
indefinite time and the Securities cannot be sold unless the Securities are
subsequently registered or an exemption from registration is available.

        I agree that I will in no event sell or distribute all or any part of
the Securities unless (1) there is an effective registration statement under the
Act and applicable state securities laws covering any such transaction involving
the Securities or (2) the Company receives an opinion of my legal counsel
(concurred in by legal counsel for the Company) stating that such transaction is
exempt from registration or the Company otherwise satisfies itself that such
transaction is exempt from registration.

        I consent to the placing of a legend on my certificate(s) for the
Securities stating that the Securities have not been registered and setting
forth the restriction on transfer contemplated hereby and to the placing of a
stop transfer order on the books of the



                                      -8-
<PAGE>   9

Company and with any transfer agents against the Securities until the Securities
may be legally resold or distributed.

        I understand that at the present time Rule 144 of the Securities and
Exchange Commission ("SEC") may not be relied on for the resale or distribution
of the Securities by me. I understand that the Company has no obligation to me
to register the Securities with the SEC and has not represented to me that it
will register the Securities.

        I AM ADVISED, PRIOR TO MY PURCHASE OF THE SECURITIES, THAT NEITHER THE
OFFERING OF THE SECURITIES NOR ANY OFFERING MATERIALS HAVE BEEN REVIEWED BY ANY
ADMINISTRATOR UNDER THE SECURITIES ACT OF 1933, THE OREGON SECURITIES LAW OR ANY
OTHER APPLICABLE SECURITIES ACT (THE "ACTS") AND THAT THE SECURITIES HAVE NOT
BEEN REGISTERED UNDER ANY OF THE ACTS AND THEREFORE CANNOT BE RESOLD UNLESS THEY
ARE REGISTERED UNDER THE ACTS OR UNLESS AN EXEMPTION FROM SUCH REGISTRATION IS
AVAILABLE.


        Dated: _______________




______________________________                  _______________________________
Taxpayer I.D. Number                            Steven Frankel

                                                Address




                                      -9-
<PAGE>   10

                                     RECEIPT


        A-Fem Medical Corporation hereby acknowledges receipt from Steven
Frankel in payment for ________ shares of Common Stock of A-Fem Medical
Corporation, a Nevada corporation, of $___________________ in the form of



                        ______  Cash
                        ______
                        ______  Check (personal, cashier's or bank certified)



                                            A-FEM MEDICAL CORPORATION

Date:____________________                   For:_______________________________







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