INSURED MUNICIPALS INCOME TR & IN QU TAX EX TRUST MUL SER 65
497J, 2000-12-28
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                                December 28, 2000



Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549-1004

Attn:  Filing Desk - Stop 1-4

     Re:  Insured Municipals Income Trust and Investors' Quality Tax-Exempt
          Trust, Multi-Series 65
          File No. 33-17110   CIK #821224

Ladies/Gentlemen:

         In accordance with the provisions of Rule 497(j) of Regulation C under
the Securities Act of 1933 (the "Securities Act") this letter serves to certify
that the most recent amendment to the Post-Effective of the subject Registration
Statement on Form S-6 for the above captioned Trust does not differ from that
which would have been filed pursuant to Rule 497(b) of the Securities Act. The
most recent amendment to the Registration Statement was filed electronically
with the commission on December 22, 2000.

                                    Very truly yours,

                                    Van Kampen Funds Inc.


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