COLUMBIA LABORATORIES INC
SC 13D/A, 1998-07-23
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 AMENDMENT NO.1
                                       to
                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934

                           Columbia Laboratories, Inc.
                                (Name of Issuer)

                          Common Stock, $.01 par value
                         (Title of Class of Securities)


                                    197779101
                                 (CUSIP Number)


                              James J. Apostolakis
                    c/o Lexington Shipping and Trading Corp.
                          950 Third Avenue, 27th Floor
                            New York, New York 10022
                                 (212) 588-1900
                     (Name, Address and Telephone Number of
                      Person Authorized to Receive Notices
                               and Communications)


                                   July 16, 1998
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box: [ ]

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  James J. Apostolakis

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF,WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      863,800 (See Item 5)
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         863,800 (See Item 5)
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  863,800 (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  3.0 %

14)      TYPE OF REPORTING PERSON
                  IN
- --------------------------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  David Ray

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      165,000
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         165,000
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  165,000

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  0.6 %

14)      TYPE OF REPORTING PERSON
                  IN
- --------------------------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Bernard Marden

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      423,700
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         423,700
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  423,700

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  1.5 %

14)      TYPE OF REPORTING PERSON
                  IN


- --------------------------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Anthony R. Campbell

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

              PF, WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      1,267,000 (See Item 5)
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         1,267,000 (See Item 5)
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  1,267,000  (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  4.4 %

14)      TYPE OF REPORTING PERSON
                  IN
- --------------------------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Christopher Castroviejo

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      330,000 (See Item 5)
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         330,000 (See Item 5)
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  330,000 (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  1.1 %

14)      TYPE OF REPORTING PERSON
                  IN
- --------------------------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D

ITEM 1. SECURITY AND ISSUER.

         This  Statement  amends  the  Schedule  13D  dated  July 16,  1998 (the
"Schedule 13D") filed by James J.  Apostolakis  and the other Reporting  Persons
named therein relating to the Common Stock, $.01 par value (the "Common Stock"),
of  Columbia  Laboratories,   Inc.,  a  Delaware  corporation  (the  "Company").
Notwithstanding  this  Amendment No. 1, the Schedule 13D speaks as of this date.
Capitalized  terms used herein without  definition have the meanings assigned to
them in the Schedule 13D.

ITEM 2 OF THE SCHEDULE 13D,  "IDENTITY AND BACKGROUND," IS AMENDED AND RESTATED
IN ITS ENTIRETY AS FOLLOWS:

         (a) - (c) This statement is being filed by James J. Apostolakis,  David
Ray, Bernard Marden,  Anthony R. Campbell and Christopher  Castroviejo,  who are
collectively referred to as the "Reporting Persons."

         An  aggregate  of  4,061,600  Shares  of  Common  Stock,   representing
approximately 14.2% of the shares of outstanding Common Stock, were beneficially
owned  by the  members  of the  group  described  in Item 4,  consisting  of the
Reporting  Persons  together  with Mr.  David  Knott  (who has filed a  separate
Schedule 13D), as of July 16, 1998.

         Mr. Apostolakis is the president, sole director and sole shareholder of
Lexington Shipping and Trading Corporation,  a Delaware corporation  ("Lexington
Corp."),  Bradmar  Trading  Corporation,  a  New  Jersey  corporation  ("Bradmar
Corp."), and Bradford Shipping,  Inc., a Delaware corporation ("Bradford Inc.").
Additionally,  Mr.  Apostolakis  is custodian for three pension plans  ("Pension
Plans"). Lexington Corp., Bradmar Corp., Bradford Inc. and the Pension Plans are
collectively referred to as the "Apostolakis Entities."

         Mr. Ray is presently employed as a real estate owner.

         Mr. Marden's present principal occupation is private investor.

         Mr.  Campbell is the managing  general  partner of TC  Management  ("TC
Management"),  a  general  partnership,  which is the sole  general  partner  of
Windsor  Partners  LP  ("Windsor  LP"),  a  Delaware  limited  partnership.   TC
Management  also  manages a managed  account  which holds shares of Common Stock
(the "TC Managed Account"). TC Management, Windsor LP and the TC Managed Account
are collectively referred to as the "Campbell Entities."

         Mr.  Castroviejo  is the  president  of the  manager  of  International
Parallax, a British Virgin Islands corporation  ("International  Parallax"), and
Mr.   Castroviejo  is  general  partner  of  Parallax  LP,  a  Delaware  limited
partnership  ("Parallax  LP").   International  Parallax  and  Parallax  LP  are
collectively referred to as the "Castroviejo  Entities." Mr. Castroviejo is also
a general partner, without management responsibility, of TC Management, the sole
general partner of Windsor LP.


<PAGE>

         The business address and the address of the principal  executive office
of Mr.  Apostolakis  is c/o  Lexington  Shipping  and Trading  Corp.,  950 Third
Avenue, 27th Floor, New York, New York 10022.

         The business address and the address of the principal  executive office
of Mr. Ray is c/o Bannister's Wharf Co., Newport, Rhode Island 02840.

         The business address and the address of the principal  executive office
of Mr. Marden is 1290 South Ocean Blvd, Palm Beach, Florida 33480.

         The business address and the address of the principal  executive office
of Mr. Campbell and Mr. Castroviejo is c/o TC Management, 237 Park Avenue, Suite
800, New York, New York 10017.

         (d) - (e) During the last five years,  none of the  Reporting  Persons,
and, to the best  knowledge of the Reporting  Persons,  none of the  Apostolakis
Entities,  Campbell  Entities or Castroviejo  Entities,  has been convicted in a
criminal proceeding  (excluding traffic violations and similar  misdemeanors) or
has been a party to a civil proceeding of a judicial or  administrative  body of
competent jurisdiction and as a result of such proceeding was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or state securities laws or finding
any violation with respect to such laws.

         (f) Each natural  person  identified in this Item 2 is a citizen of the
United States.


ITEM 3 OF THE SCHEDULE 13D, "SOURCE AND AMOUNT OF FUNDS OR OTHER
CONSIDERATION," IS AMENDED AND RESTATED IN ITS ENTIRETY AS
FOLLOWS:

         As of July  16,  1998  the  Reporting  Persons  beneficially  owned  an
aggregate of 3,054,500 shares of Common Stock, all of which were acquired in the
open market over the course of time at then-current  market prices for aggregate
consideration  of  approximately  $33,500,000.00  The costs of the  purchases by
Apostolakis Entities, Campbell Entities and Castroviejo Entities were funded out
of working capital,  which may, at any given time,  include margin loans made by
brokerage firms in the ordinary  course of business.  The costs of the purchases
made by the  individual  Reporting  Persons  were funded out of personal  funds,
which may, at any given time,  include  margin loans made by brokerage  firms in
the ordinary course of business.

ITEM 5 (A) AND (B) OF THE SCHEDULE 13D,  "INTEREST IN SECURITIES OF THE ISSUER."
ARE AMENDED AND RESTATED IN THEIR ENTIRETY AS FOLLOWS:


<PAGE>

         (a) An aggregate of 4,061,600  Shares  of  Common  Stock,  representing
approximately 14.2% of the shares of outstanding Common Stock, were beneficially
owned  by the  members  of the  group  described  in Item 4,  consisting  of the
Reporting  Persons  together  with Mr.  David  Knott  (who has filed a  separate
Schedule 13D), as of July 16, 1998.

         The Reporting Persons included in this Schedule 13D beneficially own an
aggregate of 3,054,500 shares of Common Stock, representing  approximately 10.6%
of the shares of the outstanding Common Stock./1/

         The additional  1,007,100 shares of Common Stock  beneficially owned by
David Knott,  representing an additional approximately 3.5% of the shares of the
outstanding common Stock, are reported in a Schedule 13D separately filed.

         The  following  table sets  forth the number of shares of Common  Stock
beneficially  owned  by each of the  Reporting  Persons  and  percentage  of the
outstanding  Common  Stock  such  ownership  represents.  Item 2 sets  forth the
entities which own Common Stock of which Mr.  Apostolakis,  Mr.  Campbell or Mr.
Castroviejo may be deemed beneficial owners.

                                                               Percentage of
Reporting                            Shares of                  Outstanding
Person                             Common Stock                Common Stock
- ------                             ------------                ------------

Mr. Apostolakis                       868,800/2/                    3.0

Mr. Ray                               165,000                       0.6

Mr. Marden                            423,700                       1.5

Mr. Campbell                        1,267,000                       4.4

Mr. Castroviejo/3/                    330,000                       1.1


         The  following  table sets  forth the number of shares of Common  Stock
owned by the Apostolakis Entities.

                                                               Percentage of
Apostolakis                  Shares of                          Outstanding
Entity                      Common Stock                       Common Stock
- ------                      ------------                       ------------


Lexington Corp.                48,600                               0.2

Bradmar Corp.                  36,850                               0.1

Bradford Inc.                  36,500                               0.1

Pension Plans                  17,625                               0.06


- --------
/1/ Based upon  28,684,687  shares of Common Stock reported by the Company to be
outstanding as of April 30, 1998.

/2/ Not including certain non-qualified options, not presently  exercisable,  to
purchase 50,000 shares at a price of $11.625 granted on February 2, 1998.

/3/ Through his position as a general partner, without management reponsibility,
of TC Management, the sole general partner of Windsor LP, and manager for the TC
Managed Account,  Mr.  Castroviejo may also be deemed to beneficially own shares
of Common Stock owned by Windsor LP and the TC Managed  Account,  as to which he
disclaims beneficial ownership.  The above table reflects only Mr. Castroviejo's
position as  president  of the  manager of  International  Parallax  and general
partner of Parallax LP. (See Item 2.)


<PAGE>

Additionally,  Mr. Apostolakis individually owns 724,225 shares of Common Stock,
representing approximately 2.5% of the outstanding Common Stock.

         The  following  table sets  forth the number of shares of Common  Stock
owned by the Campbell Entities.

                                                                 Percentage of
Campbell                           Shares of                      Outstanding
Entity                             Common Stock                  Common Stock
- ---------                          ------------                  ------------

TC Management/4/                   1,186,000                         4.1

Windsor LP                         1,100,000                         3.8

TC Managed Account                    86,000                          .3


         Additionally,  Mr. Campbell  individually  owns 51,000 shares of Common
Stock, and a trust estate for the benefit of Mr. Campbell's children owns 30,000
shares  of  Common  Stock  (as  to  which  Mr.  Campbell  disclaims   beneficial
ownership),  representing an aggregate of  approximately  .3% of the outstanding
Common Stock.

         The  following  table sets  forth the number of shares of Common  Stock
owned by the Castroviejo Entities.

                                                                   Percentage of
Castroviejo                      Shares of                         Outstanding
Entity                           Common Stock                      Common Stock
- ---------                        ------------                      ------------

International Parallax            315,000                              1.1

Parallax LP                        15,000                              0.05


         (b) By reason of his position as sole officer, director and shareholder
of  Lexington  Corp.,  Bradford  Inc., and Bradmar  Corp. (see  Item 2), and his
position as custodian for the Pension Plans,  Mr.  Apostolakis  may be deemed to
possess the power to vote and dispose of the shares of Common Stock beneficially
owned by the Apostolakis Entities.  Pursuant to Rule 13d-4 promulgated under the
Securities Act of 1934, as amended (the 


- -------- 
/4/ TC  Management,  as general  partner  of  Windsor  LP and  manager of the TC
Managed Account,  may be deemed to beneficially own the shares directly owned by
Windsor LP and the TC Managed Account


<PAGE>

"Securities  Exchange Act"), Mr. Apostolakis  disclaims  beneficial ownership of
such shares.

         By reason of his position as managing general partner of TC Management,
the general  partner of Windsor LP and manager for the Managed Account (see Item
2), Mr.  Campbell  may be deemed to possess the power to vote and dispose of the
shares of Common Stock beneficially owned by the Campbell Entities.  Pursuant to
Rule 13d-4 promulgated under the Securities Exchange Act, Mr. Campbell disclaims
beneficial ownership of such shares.

         By reason of his position as a general  partner of TC  Management,  the
general  partner  of  Windsor  LP,  his  position  of  president  of  manager of
International  Parallax and his position of general  partner of Parallax LP, Mr.
Castroviejo may be deemed to possess the power to vote and dispose of the shares
of Common Stock  beneficially owned by the Campbell Entities and the Castroviejo
Entities.  Pursuant to Rule 13d-4 promulgated under the Securities Exchange Act,
Mr. Castroviejo disclaims beneficial ownership of such shares.


ITEM  6  OF  THE  SCHEDULE  13D,  "CONTRACTS,  ARRANGEMENTS,  UNDERSTANDINGS  OR
RELATIONSHIPS  WITH RESPECT TO  SECURITIES OF THE ISSUER," IS AMENDED TO ADD THE
FOLLOWING NEW PARAGRAPH AT THE END THEREOF:

         Pursuant  to  the  rules  of the  Securities  and  Exchange  Commission
relating to the filing of Statements on Schedule 13D, the Reporting Persons have
executed an Agreement of Joint Filing with respect to this  Schedule  13D. It is
also understood that the Reporting Persons and Mr. Knott would share the cost of
legal counsel in this connection. (See Item 4.)


<PAGE>

                                   SIGNATURES


         After  reasonable  inquiry and to the best  knowledge and belief of the
undersigned,  the  undersigned  certify that the  information  set forth in this
Statement is true, complete and correct.


Dated:  July 23, 1998



                                                     /s/ James J. Apostolakis
                                                     --------------------------
                                                     Name:  James J. Apostolakis



                                                    /s/ David Ray
                                                    ---------------------------
                                                    Name:  David Ray


                                                    /s/ Bernard Marden
                                                    ---------------------------
                                                    Name:  Bernard Marden



                                                    /s/ Anthony R. Campbell
                                                    ---------------------------
                                                    Name: Anthony R. Campbell



                                                   /s/ Christopher Castroviejo
                                                   ----------------------------
                                                   Name: Christopher Castroviejo


<PAGE>

SCHEDULE I IS AMENDED AND RESTATED IN ITS ENTIRETY AS FOLLOWS:


                                                                      SCHEDULE I

                             TRANSACTIONS IN COMMON
                      STOCK OF COLUMBIA LABORATORIES, INC.
                          DURING THE PRECEDING 60 DAYS


Shares Purchased by James J. Apostolakis./6/

                                    Number of
                                    Shares
Date                                Purchased                    Total Cost
- ----                                ---------                    ----------

5/27/98                                  4,200                    $35,265.00
7/8/98                                   1,000                     $5,120.00
7/9/98                                   1,100                     $6,946.00
7/13/98                                  1,200                     $8,172.00

Shares Purchased by Lexington Corp.

                                    Number of
                                    Shares
Date                                Purchased                    Total Cost
- ----                                ---------                    ----------

7/13/98                                 3,000                     $20,430.00

Shares Purchased by Bradmar Corp.

                                    Number of
                                    Shares
Date                                Purchased                    Total Cost
- ----                                ---------                    ----------

7/10/98                                 2,000                     $14,500.00


Shares Purchased by Bernard Marden./7/

                                    Number of
                                    Shares
Date                                Purchased                    Total Cost
- ----                                ---------                    ----------

7/10/98                                55,400                    $387,800.00


Shares Purchased by Windsor Partners

                                    Number of
                                    Shares
Date                                Purchased                   Total Cost
- ----                                ---------                   ----------

6/16/98                                15,000                   $ 89,650.00
6/18/98                                 8,000                   $ 48,325.00
6/18/98                                52,700                   $305,685.00
7/7/98                                  2,700                   $ 14,699.50
7/14/98                                 8,000                   $ 53,665.00
7/14/98                                 2,000                   $ 13,645.00
7/14/98                                 3,500                   $ 25,242.50
                                   

Shares Sold by Windsor Partners

                                    Number of
                                    Shares
Date                                Sold                        Total Cost
- ----                                ---------                   ----------

6/17/98                                 8,100                   $ 48,605.11
6/17/98                                 6,900                   $ 41,404.35


- --------
/6/ In  addition  to the  listed  purchases,  on June 16,  1998 Mr.  Apostolakis
purchased 200 call options at $5.00 on the open market at a price of $1.625.

/7/ In addition to the listed purchases,  on June 18, 1998 Mr. Ray purchased 200
call options at $7.50 on the open market for a price of $.75.



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