COLUMBIA LABORATORIES INC
SC 13D/A, 1998-10-07
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 AMENDMENT NO. 2
                                       to
                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934

                           Columbia Laboratories, Inc.
                                (Name of Issuer)

                          Common Stock, $.01 par value
                         (Title of Class of Securities)


                                    197779101
                                 (CUSIP Number)


                              James J. Apostolakis
                    c/o Lexington Shipping and Trading Corp.
                          950 Third Avenue, 27th Floor
                            New York, New York 10022
                                 (212) 588-1900
                     (Name, Address and Telephone Number of
                      Person Authorized to Receive Notices
                               and Communications)


                                 October 2, 1998
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box: [ ]


<PAGE>


                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  James J. Apostolakis

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF,WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

         NUMBER                 7)     SOLE VOTING POWER
         OF                            815,400 (See Item 5)
         SHARES         
         BENEFICIALLY           8)     SHARED VOTING POWER
         OWNED BY                      Not Applicable
         EACH           
         REPORTING              9)     SOLE DISPOSITIVE POWER
         PERSON                        815,400 (See Item 5)
         WITH           
                                10)    SHARED DISPOSITIVE POWER
                                       Not Applicable
                        
11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  815,400 (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  2.8%

14)      TYPE OF REPORTING PERSON
                  IN
- --------------------------------------------------------------------------------


                                      -2-

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  David Ray

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

         NUMBER                  7)     SOLE VOTING POWER
         OF                             185,000
         SHARES         
         BENEFICIALLY            8)     SHARED VOTING POWER
         OWNED BY                       Not Applicable
         EACH           
         REPORTING               9)     SOLE DISPOSITIVE POWER
         PERSON                         185,000
         WITH           
                                 10)    SHARED DISPOSITIVE POWER
                                        Not Applicable
                        
11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  185,000

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  0.6%

14)      TYPE OF REPORTING PERSON
                  IN
- --------------------------------------------------------------------------------


                                      -3-

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Bernard Marden

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

         NUMBER                  7)     SOLE VOTING POWER
         OF                             423,700
         SHARES         
         BENEFICIALLY            8)     SHARED VOTING POWER
         OWNED BY                       Not Applicable
         EACH           
         REPORTING               9)     SOLE DISPOSITIVE POWER
         PERSON                         423,700
         WITH           
                                 10)    SHARED DISPOSITIVE POWER
                                        Not Applicable
                        
11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  423,700

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  1.5 %

14)      TYPE OF REPORTING PERSON
                  IN


- --------------------------------------------------------------------------------


                                      -4-

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Anthony R. Campbell

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

              WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

         NUMBER                  7)     SOLE VOTING POWER
         OF                             1,344,000 (See Item 5)
         SHARES         
         BENEFICIALLY            8)     SHARED VOTING POWER
         OWNED BY                       Not Applicable
         EACH           
         REPORTING               9)     SOLE DISPOSITIVE POWER
         PERSON                         1,344,000 (See Item 5)
         WITH           
                                 10)    SHARED DISPOSITIVE POWER
                                        Not Applicable
                        
11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  1,344,000  (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  4.7%

14)      TYPE OF REPORTING PERSON
                  IN
- --------------------------------------------------------------------------------


                                      -5-

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Christopher Castroviejo

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    [X]

                                                                     (b)    [ ]

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     [ ]

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

         NUMBER                  7)     SOLE VOTING POWER
         OF                             0 (See Item 5)
         SHARES         
         BENEFICIALLY            8)     SHARED VOTING POWER
         OWNED BY                       Not Applicable
         EACH           
         REPORTING               9)     SOLE DISPOSITIVE POWER
         PERSON                         0 (See Item 5)
         WITH           
                                 10)    SHARED DISPOSITIVE POWER
                                        Not Applicable
                        
11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  0 (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                             [ ]

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  0%

14)      TYPE OF REPORTING PERSON
                  IN
- --------------------------------------------------------------------------------


                                      -6-

<PAGE>

                                  SCHEDULE 13D


ITEM 1 OF THE SCHEDULE  13D,  "SECURITY  AND ISSUER," IS AMENDED AND RESTATED IN
ITS ENTIRETY AS FOLLOWS:

         This Statement  amends the Schedule 13D dated July 16, 1998, as amended
by Amendment No. 1 filed on July 23, 1998 (the "Schedule  13D"),  filed by James
J.  Apostolakis  and the other Reporting  Persons named therein  relating to the
Common Stock,  $.01 par value (the "Common  Stock"),  of Columbia  Laboratories,
Inc., a Delaware corporation (the "Company"). Notwithstanding this Amendment No.
2, the  Schedule  13D speaks as of this  date.  Capitalized  terms  used  herein
without definition have the meanings assigned to them in the Schedule 13D.

ITEM 2 (A) - (C) OF THE SCHEDULE 13D,  "IDENTITY AND  BACKGROUND," IS AMENDED TO
AMEND AND RESTATE THE SECOND PARAGRAPH THEREOF IN ITS ENTIRETY AS FOLLOWS:

         An  aggregate  of  3,912,800  Shares  of  Common  Stock,   representing
approximately 13.6% of the shares of outstanding Common Stock, were beneficially
owned  by the  members  of the  group  described  in Item 4,  consisting  of the
Reporting  Persons  together  with Mr.  David  Knott  (who has filed a  separate
Schedule 13D), as of October 6, 1998.

ITEM 2 (A) - (C) OF THE SCHEDULE 13D IS FURTHER AMENDED TO ADD THE FOLLOWING:

         The  Reporting  Persons  and Mr.  Knott have  formed The  Committee  to
Improve Shareholder Value of Columbia  Laboratories (the "Committee"),  of which
they are presently the sole members.

ITEM 3 OF THE SCHEDULE 13D, "SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION,"
IS AMENDED TO AMEND AND RESTATE THE FIRST  SENTENCE  THEREOF IN ITS  ENTIRETY AS
FOLLOWS:

         As of  October  6, 1998 the  Reporting  Persons  beneficially  owned an
aggregate of 2,768,100 shares of Common Stock, all of which were acquired on the
open  market  over the course of time at  then-current  prices for an  aggregate
consideration of approximately $32,231,294.

ITEM 4 OF  SCHEDULE  13D,  "PURPOSE  OF  TRANSACTION,"  IS  AMENDED  TO ADD  THE
FOLLOWING:

         During the latter part of the summer,  certain of the Reporting Persons
and Mr. Knott had further  conversations  with the Company's  senior  management
regarding immediate steps to address  shareholder  concerns over the collapse of
the  Company's  stock  price  and  the  perceived   ineffectiveness  of  current
management.

         Unfortunately,  efforts  to  pursue  those  discussions  have  not been
productive.


                                      - 7 -

<PAGE>

         Accordingly,  on October 2, 1998, the Committee formed by the Reporting
Persons and Mr. Knott wrote to the Board of  Directors of the Company,  and each
Director  individually,  to call their urgent attention to these matters. A copy
of that letter is attached as Exhibit 2 to this Amendment No. 2.

         The  Reporting  Persons are hopeful that the Company's  Directors  will
respond  constructively to their letter of October 2. In the absence of a prompt
and  positive  response,  however,  their  letter to the Board has  reserved the
alternative  of taking other  actions with  respect to the Company,  including,
without limitation,  going to court to demand that the Company schedule and hold
a 1998 annual meeting of shareholders as required by Delaware law and seeking to
nominate candidates to the Company's Board of Directors at such a meeting.

         No 1998 annual meeting of the Company's shareholders has been announced
and to the knowledge of the Reporting Persons no such meeting is scheduled.  Any
action with respect to a future shareholders meeting,  including any decision to
seek to nominate  candidates to the  Company's  Board or to take other action in
that regard,  would be pursued only in connection with such a meeting and in the
context of the circumstances  then obtaining,  and in compliance with applicable
rules of the Securities and Exchange Commission.

ITEM 5 (A) AND (C) OF THE SCHEDULE 13D,  "INTEREST IN SECURITIES OF THE ISSUER,"
ARE AMENDED AND RESTATED IN THEIR ENTIRETY AS FOLLOWS:

         (a) An  aggregate  of 3,912,800  Shares of Common  Stock,  representing
approximately 13.6% of the shares of outstanding Common Stock, were beneficially
owned  by the  members  of the  group  described  in Item 4,  consisting  of the
Reporting  Persons  together  with Mr.  David  Knott  (who has filed a  separate
Schedule 13D), as of October 6, 1998.

         The Reporting Persons included in this Schedule 13D beneficially own an
aggregate of 2,768,100 shares of Common Stock,  representing  approximately 9.7%
of the shares of the outstanding Common Stock./1/

         The  additional  1,144,700  shares of  Common  Stock,  representing  an
additional  approximately  4.0% of the shares of the  outstanding  Common Stock,
were beneficially owned by David Knott as of October 6, 1998 including 1,007,100
shares  reported in a Schedule 13D separately  filed and an aggregate of 137,600
shares of Common Stock purchased since that filing.

- -------- 
/1/ Based upon  28,684,687  shares of Common Stock reported by the Company to be
outstanding as of July 31, 1998.


                                      - 8 -

<PAGE>

         The  following  table sets  forth the number of shares of Common  Stock
beneficially  owned by each of the  Reporting  Persons as of October 6, 1998 and
the percentage of the outstanding Common Stock such ownership represents. Item 2
sets forth the  entities  which own Common Stock of which Mr.  Apostolakis,  Mr.
Campbell or Mr. Castroviejo may be deemed beneficial owners.


                                                                  Percentage of
Reporting                                       Shares of          Outstanding
Person                                        Common Stock        Common Stock
- ------                                        ------------        ------------

Mr. Apostolakis                                815,400/2/            2.8

Mr. Ray                                        185,000               0.6

Mr. Marden                                     423,700               1.5

Mr. Campbell                                 1,344,000               4.7


Mr. Castroviejo/3/                                   0                 0

         The  following  table sets  forth the number of shares of Common  Stock
owned by the Apostolakis Entities as of October 6, 1998.

                                                                 Percentage of
Apostolakis                                  Shares of            Outstanding
Entity                                      Common Stock          Common Stock
- ------                                      ------------          ------------

Lexington Corp.                                48,000                  0.2

Bradmar Corp.                                  57,850                  0.2

Bradford Inc.                                  34,000                  0.1

Pension Plans                                  17,625                  0.06

         Additionally,  Mr.  Apostolakis  individually  owns  657,925  shares of
Common Stock, representing approximately 2.3% of the outstanding Common Stock.

- --------
/2/ Not including certain non-qualified options, not presently  exercisable,  to
purchase 50,000 shares at a price of $11.625 granted on February 2, 1998.

/3/ Through his position as a general partner of TC Management, the sole general
partner of Windsor LP, Mr.  Castroviejo may also be deemed to  beneficially  own
shares of Common Stock, owned by Windsor LP, as to which he disclaims beneficial
ownership. The above table reflects only Mr. Castroviejo's position as president
of the manager of  International  Parallax  and general  partner of Parallax LP.
(see Item 2).


                                      - 9 -

<PAGE>

         The  following  table sets  forth the number of shares of Common  Stock
owned by the Campbell Entities as of October 6, 1998.


                                                                  Percentage of
Campbell                                       Shares of           Outstanding
Entity                                       Common Stock         Common Stock
- ------                                       ------------         ------------

TC Management/4/                               1,246,500               4.3

Windsor LP                                     1,185,500               4.1

TC Managed Account                                86,000                .3

         Additionally,  Mr. Campbell  individually  owns 42,500 shares of Common
Stock, and a trust estate for the benefit of Mr. Campbell's children owns 30,000
shares  of  Common  Stock  (as  to  which  Mr.  Campbell  disclaims   beneficial
ownership),  representing an aggregate of  approximately  .3% of the outstanding
Common Stock.

         The  following  table sets  forth the number of shares of Common  Stock
owned by the Castroviejo Entities as of October 6, 1998/5/.

                                                                 Percentage of
Castroviejo                                 Shares of             Outstanding
Entity                                    Common Stock           Common Stock
- ------                                    ------------           ------------

International Parallax                          0                      0

Parallax LP                                     0                      0

         Mr. Castroviejo and the Castroviejo Entities no longer hold
any shares of Common Stock as of October 6, 1998.

         (c) Except as set forth on  Schedule I annexed  hereto,  the  Reporting
Persons,  Apostolakis Entities,  Campbell Entities and Castroviejo Entities have
not effected any  transactions  in the Common Stock during the past 60 days. All
such transactions were effected in the open market.

- --------
/4/ TC  Management,  as general  partner  of  Windsor  LP and  manager of the TC
Managed Account,  may be deemed to beneficially own the shares directly owned by
Windsor LP and the TC Managed Account.

/5/  Formerly  International  Parallax  owned  15,000  shares of  Common  Stock,
representing approximately .05% of the outstanding Common Stock, and Parallax LP
owned 315,000  shares of Common Stock,  representing  approximately  1.1% of the
outstanding Common Stock. The shares held by International Parallax and Parallax
LP were inadvertently interchanged in Schedule 13D/A Amendment No. 1.


                                     - 10 -

<PAGE>

ITEM 7 OF SCHEDULE  13D,  "MATERIAL TO BE FILED AS  EXHIBITS," IS AMENDED TO ADD
THE FOLLOWING ITEM:

         Exhibit 2-            Letter  to  the  Board  of  Directors  of the
                               Company dated October 2, 1998.


                                     - 11 -

<PAGE>

                                   SIGNATURES


         After  reasonable  inquiry and to the best  knowledge and belief of the
undersigned,  the  undersigned  certify that the  information  set forth in this
Statement is true, complete and correct.


Dated:  October 6, 1998


                                                     /s/ James J. Apostolakis
                                                     --------------------------
                                                     Name:  James J. Apostolakis



                                                    /s/ David Ray
                                                    ---------------------------
                                                    Name:  David Ray


                                                    /s/ Bernard Marden
                                                    ---------------------------
                                                    Name:  Bernard Marden



                                                    /s/ Anthony R. Campbell
                                                    ---------------------------
                                                    Name: Anthony R. Campbell



                                                   /s/ Christopher Castroviejo
                                                   ----------------------------
                                                   Name: Christopher Castroviejo


                                     - 12 -

<PAGE>

SCHEDULE I IS AMENDED AND RESTATED IN ITS ENTIRETY AS FOLLOWS:


                                                    SCHEDULE I


                                              TRANSACTIONS IN COMMON
                                       STOCK OF COLUMBIA LABORATORIES, INC.
                                           DURING THE PRECEDING 60 DAYS



SHARES SOLD BY JAMES J. APOSTOLAKIS:

                                                 NUMBER OF
                                                  SHARES
DATE                                               SOLD               TOTAL COST
- ----                                               ----               ----------

8/14/98                                              3,800               $20,900
8/24/98                                             15,200                76,000
8/25/98                                             35,600               178,000
8/27/98                                             16,000                66,000
8/28/98                                             15,000                48,750


SHARES PURCHASED BY JAMES J. APOSTOLAKIS:

                                                 NUMBER OF
                                                  SHARES
DATE                                             PURCHASED           TOTAL COST
- ----                                             ---------           ----------

9/28/98                                               2,000               $7,750
10/1/98                                               2,000                6,750
10/2/98                                               3,000                9,180
10/5/98                                               6,000               17,625
10/6/98                                               6,300               17,325


SHARES PURCHASED BY BRADMAR CORP.:

                                                 NUMBER OF
                                                  SHARES
DATE                                             PURCHASED            TOTAL COST
- ----                                             ---------            ----------

9/23/98                                              10,000              $40,625
9/22/98                                               4,000               16,250
9/1/98                                               10,000               33,750


                                     - 13 -

<PAGE>



SHARES SOLD BY LEXINGTON CORP.:

                                               NUMBER OF
                                                SHARES
DATE                                              SOLD              TOTAL COST
- ----                                              ----              ----------

8/28/98                                           5,000              $16,250
8/27/98                                           2,000                8,125


SHARES PURCHASED BY LEXINGTON CORP.:

                                               NUMBER OF
                                                  SHARES
DATE                                            PURCHASED             TOTAL COST
- ----                                            ---------             ----------

10/1/98                                               2,000            $6,750
10/2/98                                               1,000             3,060
10/5/98                                               1,000             2,937.50
10/6/98                                               2,400             6,900

SHARES SOLD BY BRADFORD INC.:

                                                 NUMBER OF
                                                  SHARES
DATE                                                SOLD              TOTAL COST
- ----                                                ----              ----------

8/28/98                                           5,000                 $16,250


SHARES PURCHASED BY WINDSOR LP:

                                                  NUMBER OF
                                                   SHARES
DATE                                              PURCHASED         TOTAL COST
- ----                                              ---------         ----------
                                     
8/17/98                                            7,500             $39,837
8/19/98                                           10,000              58,950
8/21/98                                           10,000              52,150
8/24/98                                            8,000              41,137
8/26/98                                            5,000              24,075
8/26/98                                            7,500              34,350
9/30/98                                           10,000              38,125
10/6/98                                           25,000              73,750
                                     
                               
SHARES SOLD BY WINDSOR LP:

                                                  NUMBER OF
                                                   SHARES
DATE                                                 SOLD           TOTAL COST
- ----                                                 ----           ----------
                                        
8/18/98                                            4,500            $23,607
8/18/98                                            3,000             15,919


                                     - 14 -

<PAGE>


SHARES SOLD BY MR. CAMPBELL:

                                            NUMBER OF
                                             SHARES
DATE                                           SOLD                   TOTAL COST
- ----                                           ----                   ----------

8/12/98                                      2,500                     $15,475
8/26/98                                      5,000                      21,575


SHARES SOLD BY PARALLAX LP:

                                           NUMBER OF
                                            SHARES
DATE                                          SOLD                   TOTAL COST
- ----                                          ----                   ----------

9/1/98                                     265,000                    $703,946
9/3/98                                      10,000                      38,124
9/8/98                                      30,000                     116,546


SHARES SOLD BY INTERNATIONAL PARALLAX:

                                            NUMBER OF
                                             SHARES
DATE                                           SOLD                 TOTAL COST
- ----                                           ----                 ----------

9/1/98                                       15,000                 $43,913
9/23/98                                      10,000                  40,099


SHARES PURCHASED BY MR. RAY:

                                            NUMBER OF
                                             SHARES
DATE                                        PURCHASED              TOTAL COST

9/2/98                                        10,000                $38,706
9/2/98                                        10,000                 39,375


                                     - 15 -


                                    EXHIBIT 2

                      THE COMMITTEE TO IMPROVE SHAREHOLDER
                         VALUE OF COLUMBIA LABORATORIES
                            c/o Knott Partners, L.P.
                             485 Underhill Boulevard
                                Syosset, NY 11791


                                 October 2, 1998


Board of Directors
Columbia Laboratories, Inc.
2665 South Bayshore Drive
Miami, Florida  33133

Ladies and Gentlemen:

         Our Committee has been formed by several  significant  shareholders  of
the Company who have  developed  very serious  concerns with many aspects of the
Company's affairs.  Since members of the Committee publicly filed a statement on
Schedule 13D last July, we have been  contacted by many other  shareholders  who
appear to share our sense of outrage  over the collapse of the  Company's  stock
price and the perceived ineffectiveness of current management.

         For  months,  members of the  Committee  have sought to pursue a dialog
with the Company's senior management  regarding immediate steps to address these
concerns and improve the Company's business and financial  situation,  enhancing
value for all of its shareholders.

         Unfortunately,  our efforts to pursue those  discussions  have not been
productive,  and to our great  disappointment  we have found  senior  management
entirely  unprepared  to focus on the  Company's  most  serious  problems  or to
discuss with open minds  constructive  action to address the Company's  pressing
difficulties.  We write now in an effort to call the  urgent  attention  of each
Director to these vital matters.

         In the absence of a prompt and positive  response,  we must reluctantly
conclude that further  communication  with senior  management will be fruitless,
and that shareholders wishing to assist the Company and protect their investment
must take other action.  We expect that action to include,  without  limitation,
going to court to demand that


<PAGE>


Board of Directors
October 2, 1998
Page 2



the Company  schedule and hold a 1998 annual meeting of shareholders as required
by Delaware law and nominating qualified candidates for election to the Board at
such a meeting.

         We have repeatedly  attempted to explore shareholder concerns in detail
with the  Company's  senior  management.  Among  the most  significant  of those
concerns are the following:

         Stock Price and Shareholder  Value. The Committee  understands that the
Company's Common Stock is reported to be one of the ten worst performing  public
stocks  during  the past  year.  In fact,  over the last  twelve  months,  since
September 30, 1997, the Company's Common Stock has lost almost 80% of its value,
declining from $19 1/8 to $3 1/4 per share, and recently traded as low as $2 3/8
per share. We believe that this decline is attributable to bad management rather
than the inherent  potential of the Company and its  business.  Immediate  steps
must be taken to restore investor  confidence,  management  accountability,  and
credibility in the financial  community,  including  addressing the other issues
discussed in detail below.

         Management Compensation.  Despite the Company's disastrous performance,
over the last three years the three  senior  officers  of the Company  have been
given salary  increases  which have almost  doubled their base salaries and been
granted stock options to acquire a total of 1,350,000  shares.  These  excessive
and unjustified compensation increases include salary increases to $300,000 from
$167,500 per year, and a grant of 450,000 options,  for the Company's  part-time
Chief  Operating  Officer,  who  apparently  spends little time on the Company's
affairs.  Even after  entering a new  four-year  employment  agreement  with the
Company in April 1997, this officer evidently went back to the Company just five
months later,  in September  1997, for a further salary increase of $100,000 per
year.  The level of last year's option grants to each member of the  ineffective
senior  management  group is at least ten times  that of the grant to the senior
scientific officer directly responsible for key product development,  while that
individual  received a total  salary  increase  of only 10% over the  three-year
period  during  which  senior  management  salaries  increased  by almost  100%.
Moreover, as the Company's stock price has fallen and its shareholders have lost
tremendous  value,  the  exercise  price  of stock  options  granted  to  senior
management has been unilaterally  lowered for the benefit of those officers.  We
believe  that   management   compensation   should  be  based  on   demonstrated
performance, and that option grants should be


<PAGE>


Board of Directors
October 2, 1998
Page 3

designed to give  management an interest in the Company which coincides with the
interests of its shareholders.

         Corporate Expense. After repeated demands from members of our Committee
and a public Schedule 13D filing  expressing our concern,  management  belatedly
announced a new plan to reduce research and  development  expense by $5 million.
Whether those measures will be  successfully  implemented by present  management
remains  uncertain.  In any event,  the  Company  continues  to be  burdened  by
exceptional and unnecessary  corporate overhead,  travel and entertainment,  and
other expenses. For example,  apartments are maintained at the Company's expense
in New York City and Paris, France. The Committee  understands that the New York
apartment  is often  utilized by relatives of senior  management  (while  senior
management  members  themselves choose to spend additional Company money staying
in expensive hotels when visiting the city), and that the Paris apartment serves
as the personal  residence of the Company's  Chairman and his family.  Moreover,
the Company  unnecessarily  spends more than $107,000 per year in rent alone, in
addition to undisclosed  salaries and other expenses,  maintaining an office and
support staff in the Miami,  Florida area (where it has limited  operations) for
the convenience of its Chief Executive Officer and Chief Operating Officer,  who
are  engaged  in  local  business  activities  unrelated  to the  Company.  Such
decentralized   operations   would  be  wasteful  and   inefficient   under  any
circumstances. For an enterprise in the Company's dire financial condition, they
are simply indefensible.  We believe that the Miami area office should be closed
and  the  Company's  American  operations  consolidated  in  a  single  location
convenient   to  the  focus  of  its   important   business   relations  in  the
pharmaceutical industry.

         Management  Credibility.   We  have  repeatedly  stressed  that  senior
management is perceived by elements of the business and  financial  community as
lacking  candor  and  credibility.  The  individual  nominally  serving as Chief
Operating Officer, whose primary stated responsibility is investor relations and
corporate communications,  has apparently done little or nothing in that regard,
leaving this important task to the Chairman. While the Chairman may be qualified
to serve as the Company's most senior scientific officer, we believe that he has
been  completely  ineffective in his other role. In fact, it seems that repeated
misjudgments and failure to meet announced  business  expectations  have all but
destroyed  management's   credibility  with  the  financial  community.   Senior
management  has been  consistently  wrong and failed to meet their own estimates
and  projections  regarding  such vital  matters as timing of product  launches,
timing of product  reorders,  product  revenues,  product  positioning,  product
competition, product acceptance, product labeling and


<PAGE>

Board of Directors
October 2, 1998
Page 4

side effects,  and earnings.  Because of their  disillusionment  and frustration
with senior  management,  we understand  that financial  analysts who previously
followed the Company's stock no longer do so, further crippling efforts to raise
capital,  attract  investor  interest  and  maintain  a  stable  market  for the
Company's stock. Responsibility for the Company's crucial investor relations and
corporate  communication functions must be effectively  re-allocated,  either to
qualified individuals within the Company or outsiders.

         Management  Performance.  The  Chief  Operating  Officer,  left with no
apparent duties with the Company after relinquishing responsibility for investor
relations  to the  Chairman,  is still  employed  at great  expense  despite the
Company's past assurances  that his departure was imminent.  The Company's Chief
Executive  Officer is perceived as devoting  insufficient time and energy to the
Company's affairs and being  inaccessible to investors,  while pursuing numerous
unrelated business activities.  In connection with one such venture, he borrowed
money against the Company's  stock and was ultimately  compelled to sell 182,000
shares.   Meanwhile,   in  the  Chief  Executive   Officer's   primary  area  of
responsibility  for the Company,  over-the-counter  products,  results have been
disastrous.  The Chairman  should  return his focus to product  development  and
scientific  matters.  The Chief Executive  Officer and Chief  Operating  Officer
should be replaced  with  qualified  individuals  who can address the  Company's
business problems and regain the confidence of the financial community.

         Board Composition and Conduct. Despite the Company's pressing problems,
the Board of  Directors  met only three  times  during the last  fiscal  year --
sometimes by telephone.  In addition, we believe that the Company suffers from a
lack of additional independent Directors capable of bringing a range of business
experience,  objectivity and judgment to bear on the Company's  affairs.  Of the
eight present Directors,  four are Company officers,  one is a close relative of
an officer,  and others have business or personal ties to Company  officers.  We
believe  that the Board must be  re-aligned  to  protect  the  interests  of the
shareholders.

         Financial  Management.  Senior management has repeatedly  permitted the
Company  to   confront   severe   cash   shortages   and  been  forced  to  make
disadvantageous  arrangements under pressure to prevent the Company from running
out of money  altogether.  In addition,  it appears that senior  management  has
expended  millions of dollars on work toward an AIDS drug in which they now seem
to have  lost  interest.  We  believe  that  this lack of  planning  and  fiscal
responsibility has discouraged serious investors from acquiring


<PAGE>

Board of Directors
October 2, 1998
Page 5

and holding the Company's  stock.  New measures must be  implemented  to restore
fiscal responsibility.

         Product  Introduction and Marketing.  We believe that senior management
has  failed to  effectively  coordinate  and  monitor  the  introduction  of the
Company's  important  new  products.  In our view,  the  Company's  business was
seriously  damaged  by  mishandling  the  significant  relationships  with  Lake
Pharmaceuticals and Warner-Lambert.  We also believe that management  mishandled
negotiations for the  introduction and marketing of Crinone,  its most promising
new product, by the Wyeth-Ayerst Laboratories division of American Home Products
Corporation  and failed to monitor the timing of that  process.  We believe that
the potential for the Company's  products  remains very promising.  However,  it
appears  to us  that  management  failure  has  prevented  the  Company  and its
shareholders from receiving the benefit of the introduction of these products.

         Shareholder  Meetings and Corporate  Governance.  Senior management has
still not scheduled the 1998 annual  meeting of  shareholders,  more than a year
after the last meeting was held. As stated,  the  Committee  intends to apply to
Delaware  Chancery  Court  for an  order  that a  shareholders  meeting  be held
promptly as required by Section 211 of the Delaware General Corporation Law. The
failure to schedule a 1998 annual meeting,  forcing  shareholders to go to court
in order to exercise their franchise as the owners of the corporation,  reflects
senior management's  indifference to ordinary standards of corporate  governance
and the legitimate interests of all shareholders.

         We believe that it is imperative  that the Board take immediate  action
to address the Company's situation, including the following:

         o        Remove and  replace the  Company's  inactive  and  ineffective
                  senior officers including the Chief Executive  Officer,  Chief
                  Operating Officer and Chief Financial Officer,  bringing in an
                  experienced pharmaceutical industry executive. If necessary, a
                  recognized executive search firm should be retained
                  to assist in this process.

         o        Revise    management    compensation    and    implement    an
                  incentive-based system which rewards management dedication and
                  demonstrable performance.


<PAGE>

Board of Directors
October 2, 1998
Page 6

         o        Undertake  a detailed  review of the  Company's  expenses  and
                  develop a  responsible  budget for a business in the Company's
                  position.  Close the Company's unnecessary and expensive Miami
                  area office and consolidate  American operations in a location
                  convenient to the focus of the pharmaceutical industry.

         o        Restore   credibility   with  the   financial   community   by
                  identifying qualified  individuals,  whether inside or outside
                  the  organization,   to  deal  with  investor   relations  and
                  corporate communications.

         o        Require full Board meetings at least  monthly.  Add additional
                  independent  directors to bring  perspective,  experience  and
                  objective  oversight  to bear  on the  Company's  affairs  and
                  demand management accountability.

         o        Immediately schedule an annual meeting of the Company's 
                  shareholders as provided by Delaware law.

         o        Engage investment  bankers to consider and report to the Board
                  regarding  strategic  alternatives and prospects for enhancing
                  shareholder value, including a merger or sale of the Company.

         The  Committee  and, we  believe,  many other  shareholders  are deeply
concerned by these and other  serious  issues  facing the Company.  We urge each
Board  member to take the time to consider  our  concerns.  We would be happy to
meet with any members of the Board to discuss these matters and we invite you to
contact us, through Mr. David Knott at 516-364-0303, for that purpose.

                                            Very truly yours,


                                            The Committee to Improve Shareholder
                                            Value of Columbia Laboratories




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