COLUMBIA LABORATORIES INC
SC 13D/A, 1998-11-09
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 AMENDMENT NO. 3
                                       to
                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934

                           Columbia Laboratories, Inc.
                           ---------------------------
                                (Name of Issuer)

                          Common Stock, $.01 par value
                          ----------------------------
                         (Title of Class of Securities)


                                    197779101
                                    ---------
                                 (CUSIP Number)


                              James J. Apostolakis
                    c/o Lexington Shipping and Trading Corp.
                          950 Third Avenue, 27th Floor
                            New York, New York 10022
                                 (212) 588-1900
                                 --------------
                     (Name, Address and Telephone Number of
                      Person Authorized to Receive Notices
                               and Communications)


                                November 4, 1998
                                ----------------
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box: |_|






<PAGE>

<TABLE>
<CAPTION>

                                         SCHEDULE 13D
CUSIP No. 197779101                      
- -------------------                      
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               James J. Apostolakis
- -------------------------------------------------------------------------------------------------
<S>                                                                   <C>    

2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                          (a)|X| *

                                                                                  (b)|_|

          * Disclaimed
- -------------------------------------------------------------------------------------------------
3)      SEC USE ONLY

- -------------------------------------------------------------------------------------------------
4)      SOURCE OF FUNDS

               PF,WC
- -------------------------------------------------------------------------------------------------
5)      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
        TO ITEMS 2(d) OR 2(e)                                                                                              

- -------------------------------------------------------------------------------------------------
6)      CITIZENSHIP OR PLACE OF ORGANIZATION

               United States
- -------------------------------------------------------------------------------------------------
                         7)    SOLE VOTING POWER 
                               926,000 (See Item 5)
        NUMBER                                                                                        
                         ------------------------------------------------------------------------
        OF               8)    SHARED VOTING POWER
        SHARES                 Not Applicable
        BENEFICIALLY                                                                                                   
                         ------------------------------------------------------------------------
        OWNED BY         9)    SOLE DISPOSITIVE POWER
        EACH                   926,000 (See Item 5)
        REPORTING                                                                                                     
                         ------------------------------------------------------------------------
        PERSON           10)   SHARED DISPOSITIVE POWER
        WITH                   Not Applicable

- -------------------------------------------------------------------------------------------------
11)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               926,000 (See Item 5)
- -------------------------------------------------------------------------------------------------
12)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
        SHARES                                                                       |_|
- -------------------------------------------------------------------------------------------------
13)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
               3.2 %
- -------------------------------------------------------------------------------------------------
14)     TYPE OF REPORTING PERSON
               IN
- -------------------------------------------------------------------------------------------------




<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101                       
- -------------------                       
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               David Ray
- -------------------------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                          (a)|X| *

                                                                                  (b)|_|
          *Disclaimed                                                                                                          
- -------------------------------------------------------------------------------------------------
3)      SEC USE ONLY

- -------------------------------------------------------------------------------------------------
4)      SOURCE OF FUNDS

               PF
- -------------------------------------------------------------------------------------------------
5)      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
        TO ITEMS 2(d) OR 2(e)                                                        |_|           
- -------------------------------------------------------------------------------------------------
6)      CITIZENSHIP OR PLACE OF ORGANIZATION

               United States
- -------------------------------------------------------------------------------------------------
                         7)    SOLE VOTING POWER
                               214,000
        NUMBER                                                                                                         
                         ------------------------------------------------------------------------
        OF               8)    SHARED VOTING POWER
        SHARES                 Not Applicable
        BENEFICIALLY                                                                                                   
                         ------------------------------------------------------------------------
        OWNED BY         9)    SOLE DISPOSITIVE POWER
        EACH                   214,000
        REPORTING                                                                                                     
                         ------------------------------------------------------------------------
        PERSON           10)   SHARED DISPOSITIVE POWER
        WITH                   Not Applicable

- -------------------------------------------------------------------------------------------------
11)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               214,000
- -------------------------------------------------------------------------------------------------
12)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
        SHARES                                                                    |_|
- -------------------------------------------------------------------------------------------------
13)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
               0.7 %
- -------------------------------------------------------------------------------------------------
14)     TYPE OF REPORTING PERSON
               IN
- -------------------------------------------------------------------------------------------------




<PAGE>

                                         SCHEDULE 13D
CUSIP No. 197779101  
- -------------------  
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               Bernard Marden
- -------------------------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                          (a)|X| *

                                                                                  (b)|_|
          *Disclaimed
- -------------------------------------------------------------------------------------------------
3)      SEC USE ONLY

- -------------------------------------------------------------------------------------------------
4)      SOURCE OF FUNDS

               PF
- -------------------------------------------------------------------------------------------------
5)      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
        TO ITEMS 2(d) OR 2(e)                                                        |_|                                      
- -------------------------------------------------------------------------------------------------
6)      CITIZENSHIP OR PLACE OF ORGANIZATION

               United States
- -------------------------------------------------------------------------------------------------
                         7)    SOLE VOTING POWER
                               473,700
        NUMBER                                                                                                         
                         ------------------------------------------------------------------------
        OF               8)    SHARED VOTING POWER
        SHARES                 Not Applicable
        BENEFICIALLY                                                                                                   
                         ------------------------------------------------------------------------
        OWNED BY         9)    SOLE DISPOSITIVE POWER
        EACH                   473,700
        REPORTING                                                                                                     
                         ------------------------------------------------------------------------
        PERSON           10)   SHARED DISPOSITIVE POWER
        WITH                   Not Applicable

- -------------------------------------------------------------------------------------------------
11)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               473,700
- -------------------------------------------------------------------------------------------------
12)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
        SHARES                                                                    |_|
- -------------------------------------------------------------------------------------------------
13)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
               1.7 %
- -------------------------------------------------------------------------------------------------
14)     TYPE OF REPORTING PERSON
               IN
- -------------------------------------------------------------------------------------------------




<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101                       
- -------------------                       
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               Christopher Castroviejo
- -------------------------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                          (a)|X| *

                                                                                  (b)|_|
          *Disclaimed
- -------------------------------------------------------------------------------------------------
3)      SEC USE ONLY

- -------------------------------------------------------------------------------------------------
4)      SOURCE OF FUNDS

               WC
- -------------------------------------------------------------------------------------------------
5)      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
        TO ITEMS 2(d) OR 2(e)                                                        |_|                                      
- -------------------------------------------------------------------------------------------------
6)      CITIZENSHIP OR PLACE OF ORGANIZATION

               United States
- -------------------------------------------------------------------------------------------------
                         7)    SOLE VOTING POWER 0 (See Item 5)
        NUMBER                                                                                                         
                         ------------------------------------------------------------------------
        OF               8)    SHARED VOTING POWER
        SHARES                 Not Applicable
        BENEFICIALLY                                                                                                   
                         ------------------------------------------------------------------------
        OWNED BY         9)    SOLE DISPOSITIVE POWER
        EACH                   0 (See Item 5)
        REPORTING                                                                                                     
                         ------------------------------------------------------------------------
        PERSON           10)   SHARED DISPOSITIVE POWER
        WITH                   Not Applicable

- -------------------------------------------------------------------------------------------------
11)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               0 (See Item 5)
- -------------------------------------------------------------------------------------------------
12)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
        SHARES                                                                       |_|
- -------------------------------------------------------------------------------------------------
13)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
               0 %
- -------------------------------------------------------------------------------------------------
14)     TYPE OF REPORTING PERSON
               IN
- -------------------------------------------------------------------------------------------------


</TABLE>


<PAGE>

                                  Schedule 13D
                                  ------------


Item 1 of the Schedule  13D,  "Security  and Issuer," is amended and restated in
its entirety as follows:

               This  Statement  amends the Schedule 13D dated July 16, 1998,  as
amended by Amendment  No. 1 filed on July 23, 1998 and by Amendment  No. 2 filed
on October 6, 1998 (the "Schedule  13D"),  filed by James J. Apostolakis and the
other  Reporting  Persons named therein  relating to the Common Stock,  $.01 par
value  (the  "Common  Stock"),  of  Columbia  Laboratories,   Inc.,  a  Delaware
corporation (the "Company").  Notwithstanding this Amendment No. 3, the Schedule
13D speaks as of this date.  Capitalized  terms used herein  without  definition
have the meanings  assigned to them in the Schedule 13D,  except for  "Reporting
Persons," as explained below.

               In each  case,  the  filing of the  Schedule  13D and  Amendments
thereto does not constitute an admission that the Reporting Persons constitute a
"group" for purposes of the Securities  Exchange Act of 1934, as amended, or the
rules promulgated  thereunder or for any other purpose  whatsoever.  Each of the
Reporting Persons expressly disclaims  beneficial  ownership of any Common Stock
beneficially owned by any of the other Reporting Persons or any other person.

               Although  included in the prior  Schedule 13D filing,  Anthony R.
Campbell  will file a  separate  Schedule  13D  which  reflects  his  beneficial
ownership  and the  beneficial  ownership  of the  Campbell  Entities  of Common
Shares.  All  references  to the  "Reporting  Persons"  shall include all of the
previous persons filing this Schedule 13D except for Mr. Campbell.

Item 2 (a) - (c) of the Schedule 13D,  "Identity and  Background," is amended to
amend and restate the second paragraph thereof in
its entirety as follows:

               An aggregate of 4,315,100  shares of common  stock,  representing
approximately  15% of the shares of outstanding  Common Stock, were beneficially
owned by the various  Reporting  Persons  included in this Schedule 13D together
with Mr.  Anthony R.  Campbell  (who has filed a separate  schedule 13D) and Mr.
David Knott (who has filed a separate Schedule 13D), as of November 4, 1998.

Item 3 of the Schedule 13D, "Source and Amount of Funds or other Consideration,"
is amended to amend and restate the first
sentence thereof in its entirety as follows:

               As  of  November  4,  1998,   the   various   Reporting   Persons
beneficially  owned an  aggregate of 1,613,700  shares of Common  Stock,  all of
which were acquired on the open market over the




<PAGE>

course  of  time  at  then-current  prices  for an  aggregate  consideration  of
approximately $32,845,499.

Items 5 (a) and (c) of the Schedule 13D, "Interest in Securities of the Issuer,"
are amended and restated in their entirety as follows:

               (a)  An   aggregate  of   4,315,100   shares  of  Common   Stock,
representing  approximately 15% of the shares of outstanding  Common Stock, were
beneficially  owned by the various  Reporting  Persons included in this Schedule
13D together with Mr.  Anthony R.  Campbell  (who has filed a separate  Schedule
13D) and Mr. David Knott (who has filed a separate Schedule 13D), as of November
4, 1998.

               The  various  Reporting  Persons  included in this  Schedule  13D
beneficially own an aggregate of 1,613,700 shares of Common Stock,  representing
approximately 5.6% of the shares of outstanding Common Stock.1

               An additional  1,240,300 shares of Common Stock,  representing an
additional  approximately  4.3% of the shares of the  outstanding  Common Stock,
were  beneficially  owned  by David  Knott  as of  November  4,  1998  including
1,155,500 shares reported in a Schedule 13D separately filed and an aggregate of
84,800 shares of Common Stock purchased since that filing.

               An additional  1,461,100 shares of Common Stock,  representing an
additional  approximately  5.1% of the shares of outstanding  Common Stock, were
beneficially owned by Anthony R. Campbell as of November 4, 1998,  reported in a
Schedule 13D separately filed.

               The  following  table  sets  forth the number of shares of Common
Stock beneficially owned by each of the Reporting Persons as of November 4, 1998
and the percentage of the  outstanding  Common Stock such ownership  represents.
Item 2 sets forth the entities  which own Common Stock of which Mr.  Apostolakis
or Mr.
Castroviejo may be deemed beneficial owners.

                                                                  Percentage of
Reporting                                 Shares of                Outstanding
Person                                  Common Stock              Common Stock
- ------                                  ------------              ------------

Mr. Apostolakis                           926,0002/2/                  3.2

Mr. Ray                                    214,000                     0.7

- ------------------------------
/1/ Based upon  28,684,687 shares of Common Stock reported by the Company to be
outstanding as of July 31, 1998. 

/2/ Not including certain non-qualified  options, not  presently  exercisable,
to  purchase  50,000  shares at a price of $11.625 granted on February 2, 1998.




<PAGE>

Mr. Marden                                 473,700                      1.7

Mr. Castroviejo/3/                            0                          0

        The  following  table sets  forth the  number of shares of Common  Stock
owned by the Apostolakis Entities as of November 4, 1998.

                                                                 Percentage of
Apostolakis                             Shares of                 Outstanding
Entity                                 Common Stock              Common Stock
- ------                                 ------------              ------------

Lexington Corp.                           68,500                      0.2

Bradmar Corp.                             57,850                      0.2

Bradford Inc.                             42,500                      0.1

Pension Plans                             17,625                     0.06

        Additionally, Mr. Apostolakis individually owns 739,525 shares of Common
Stock, representing approximately 2.6% of the outstanding Common Stock.

        The  following  table sets  forth the  number of shares of Common  Stock
owned by the Castroviejo Entities as of November 4, 19984.

                                                                 Percentage of
Castroviejo                              Shares of                Outstanding
Entity                                 Common Stock              Common Stock
- ------                                 ------------              ------------

International Parallax                       0                         0

Parallax LP                                  0                         0

        Mr.  Castroviejo and the Castroviejo  Entities no longer hold any shares
of Common Stock as of November 4, 1998.

        Each of the Reporting Persons expressly disclaims  beneficial  ownership
of any Common Stock  beneficially owned by any of the other Reporting Persons or
any other person.

- -------------------------------
/3/ Through his position as a general partner of TC Management, the sole general
partner of Windsor LP, Mr.  Castroviejo may also be deemed to  beneficially  own
shares of Common Stock, owned by Windsor LP, as to which he disclaims beneficial
ownership. The above table reflects only Mr. Castroviejo's position as president
of the manager of  International  Parallax  and general  partner of Parallax LP.
(see Item 2).

/4/ Formerly   International  Parallax  owned  15,000 shares  of  Common  Stock,
representing approximately .05% of the outstanding Common Stock, and Parallax LP
owned 315,000  shares of Common Stock,  representing  approximately  1.1% of the
outstanding Common Stock. The shares held by International Parallax and Parallax
LP were inadvertently interchanged in Schedule 13D/A Amendment No. 1.




<PAGE>

        (c) Except as set forth on  Schedule  I annexed  hereto,  the  Reporting
Persons,  Apostolakis  Entities and  Castroviejo  Entities have not effected any
transactions in the Common Stock during the past 60 days. All such  transactions
were effected in the open
market.

Item  6  of  Schedule   13D,   "Contracts,   Arrangements,   Understandings   or
Relationships with Respect to Securities of the Issuer," is amended and restated
in its entirety  as follows:  

         Notwithstanding  certain  discussions  with the  Company's  management,
there is no present  understanding between the Reporting Person and the Company.
Except  as  disclosed  herein  in  connection  with  certain  contacts  with the
Company's  senior  management  and  related  matters,  there  are no  contracts,
arrangements,  understandings  or relationships  required to be disclosed herein
with respect to the Company's  securities  between each of the Reporting Persons
and each of Messrs. Campbell or Knott. (See Item 4.)



<PAGE>

                                   SIGNATURES
                                   ----------


               After reasonable  inquiry and to the best knowledge and belief of
the undersigned,  the undersigned certify that the information set forth in this
Statement is true, complete and correct.


Dated:  November 9, 1998



                                                       /s/ James J. Apostolakis
                                                       ------------------------
                                                    Name:  James J. Apostolakis


                                                                  /s/ David Ray
                                                                  -------------
                                                               Name:  David Ray


                                                             /s/ Bernard Marden
                                                             ------------------
                                                          Name:  Bernard Marden


                                                    /s/ Christopher Castroviejo
                                                    ---------------------------
                                                        Christopher Castroviejo




<PAGE>

         SCHEDULE I IS AMENDED AND RESTATED IN ITS ENTIRETY AS FOLLOWS:


                                   SCHEDULE I


                             TRANSACTIONS IN COMMON
                      STOCK OF COLUMBIA LABORATORIES, INC.
                          DURING THE PRECEDING 60 DAYS



Shares Purchased by James J. Apostolakis:

                                    Number of
                                     Shares
Date                                Purchased                       Total Cost
- ----                                ---------                       ----------

9/28/98                               2,000                           $7,750
10/1/98                               2,000                            6,750
10/2/98                               3,000                            9,180
10/5/98                               6,000                           17,625
10/6/98                               6,300                           17,325
10/7/98                               4,000                           12,215
10/8/98                               7,000                           18,730
10/9/98                               7,000                           18,730
10/12/98                              2,000                            5,428
10/13/98                              2,200                            5,574.50
10/15/98                              4,000                           10,955
10/20/98                              6,000                           21,055
10/21/98                              3,400                           12,225
10/26/98                             10,000                           38,755
10/27/98                              5,000                           18,317.50
10/28/98                              8,000                          26,4678.50
10/29/98                             15,000                           48,880
11/2/98                               8,000                           29,360



Shares Purchased by Bradford Inc.:

                                    Number of
                                     Shares
Date                                Purchased                       Total Cost
- ----                                ---------                       ----------

10/7/98                               1,000                           $3,065
10/12/98                              1,000                         2,752.50
10/15/98                              2,000                            5,500
10/20/98                              2,000                            7,375
10/27/98                              1,000                         3,752.50
10/29/98                              1,500                            4,950








<PAGE>

Shares Purchased by Lexington Corp.:

                                    Number of
                                     Shares
Date                                Purchased                     Total Cost
- ----                                ---------                     ----------

10/1/98                               2,000                          $6,750
10/2/98                               1,000                           3,060
10/5/98                               1,000                           2,937.50
10/6/98                               2,400                           6,900
10/12/98                              1,000                           2,752.50
10/13/98                              1,000                           2,565
10/15/98                              2,000                           5,500
10/20/98                              3,000                          11,217.50
10/21/98                              1,000                           3,627.50
10/26/98                              2,000                           7,375.50
10/27/98                              2,000                           7,500
10/28/98                              2,000                           6,875
10/29/98                              4,000                          13,205
11/2/98                               2,500                           9,500

Shares Sold by Parallax LP:

                                    Number of
                                     Shares
Date                                   Sold                         Total Cost
- ----                                ----------                      ----------

9/8/98                               30,000                         $116,546


Shares Sold by International Parallax:

                                    Number of
                                     Shares
Date                                   Sold                         Total Cost
- ----                                 ---------                      -----------

9/23/98                               10,000                          $40,099


Shares Purchased by Mr. Ray:

                                    Number of
                                     Shares
Date                                Purchased                        Total Cost
- ----                                ---------                        ----------

10/9/98                               1,000                            $2,750
10/26/98                             24,100                            85,600
10/27/98                              3,900                            13,650



<PAGE>

Shares Purchased by Mr. Marden:

                                    Number of
                                     Shares
Date                                Purchased                       Total Cost
- ----                                ---------                       ----------

10/16/98                              50,000                         $150,000




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