COLUMBIA LABORATORIES INC
SC 13D, 1998-07-17
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934

                           Columbia Laboratories, Inc.
                                (Name of Issuer)

                          Common Stock, $.01 par value
                         (Title of Class of Securities)


                                    197779101
                                 (CUSIP Number)


                              James J. Apostolakis
                    c/o Lexington Shipping and Trading Corp.
                          950 Third Avenue, 27th Floor
                            New York, New York 10022
                                 (212) 588-1900
                     (Name, Address and Telephone Number of
                      Person Authorized to Receive Notices
                               and Communications)


                                  July 6, 1998
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box: |_|










<PAGE>



                                  SCHEDULE 13D
CUSIP No. 197779101                                                        
- -------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  James J. Apostolakis

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)    |X|

                                                                   (b)    |_|

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF,WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                               |_|

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      863,800 (See Item 5)
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         863,800 (See Item 5)
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  863,800 (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                         |_|

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  3.0 %

14)      TYPE OF REPORTING PERSON
                  IN
- ----------------------------------------------------------------


<PAGE>

                                                   SCHEDULE 13D
CUSIP No. 197779101                                                      
- -------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  David Ray

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP           (a)    |X|

                                                                    (b)    |_|

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                     |_|

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      165,000
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         165,000
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  165,000

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                            |_|

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  0.6 %

14)      TYPE OF REPORTING PERSON
                  IN
- -------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101                                          
- -------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Bernard Marden

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)    |X|

                                                                   (b)    |_|

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  PF

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                  |_|

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      423,700
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         423,700
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  423,700

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                          |_|

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  1.5 %

14)      TYPE OF REPORTING PERSON
                  IN
- ----------------------------------------------------------------


<PAGE>


                                  SCHEDULE 13D
CUSIP No. 197779101
- -------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Anthony R. Campbell

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)    |X|

                                                                   (b)    |_|

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                    |_|

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      1,086,500 (See Item 5)
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         1,086,500 (See Item 5)
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  1,086,500  (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                           |_|

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  3.8 %

14)      TYPE OF REPORTING PERSON
                  IN



<PAGE>


                                  SCHEDULE 13D
CUSIP No. 197779101                                      
- -------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Christopher Castroviejo

2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)    |X|

                                                                     (b)    |_|

3)       SEC USE ONLY


4)       SOURCE OF FUNDS

                  WC

5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(D) OR 2(E)                                   |_|

6)       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

                               7)     SOLE VOTING POWER
                                      330,000 (See Item 5)
         NUMBER
         OF                    8)     SHARED VOTING POWER
         SHARES                       Not Applicable
         BENEFICIALLY
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         330,000 (See Item 5)
         REPORTING
         PERSON                10)    SHARED DISPOSITIVE POWER
         WITH                         Not Applicable

11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  330,000 (See Item 5)

12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                       |_|

13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  1.1 %

14)      TYPE OF REPORTING PERSON
                  IN



<PAGE>

                                  SCHEDULE 13D


ITEM 1.           SECURITY AND ISSUER.

                  This  Statement on Schedule 13D (the  "Statement")  relates to
the Common Stock, $.01 par value (the "Common Stock"), of Columbia Laboratories,
Inc., a Delaware corporation (the "Company"). The principal executive offices of
the Company are located at 2665 South Bayshore Drive, Miami, Florida, 33133.

ITEM 2.           IDENTITY AND BACKGROUND.

                  (a)  -  (c)  This   statement  is  being  filed  by  James  J.
Apostolakis,  David Ray,  Bernard  Marden,  Anthony R. Campbell and  Christopher
Castroviejo, who are collectively referred to as the "Reporting Persons."

                  Mr.  Apostolakis  is the  president,  sole  director  and sole
shareholder  of  Lexington   Shipping  and  Trading   Corporation,   a  Delaware
corporation  ("Lexington  Corp."),  Bradmar  Trading  Corporation,  a New Jersey
corporation   ("Bradmar  Corp."),  and  Bradford  Shipping,   Inc.,  a  Delaware
corporation ("Bradford Inc."). Additionally, Mr. Apostolakis custodian for three
pension plans ("Pension Plans").  Lexington Corp., Bradmar Corp.,  Bradford Inc.
and  the  Pension  Plans  are  collectively  referred  to  as  the  "Apostolakis
Entities."

                  Mr. Ray is presently employed as a real estate owner.

                  Mr. Marden's present principal occupation is private investor.

                  Mr. Campbell is the managing  general partner of TC Management
("TC Management"),  a general partnership,  which is the sole general partner of
Windsor  Partners  LP  ("Windsor  LP"),  a  Delaware  limited  partnership.   TC
Management  and  Windsor  LP  are  collectively  referred  to as  the  "Campbell
Entities."

                  Mr.   Castroviejo   is  the   president   of  the  manager  of
International  Paralax,  a British  Virgin Islands  corporation  ("International
Paralax"),  and Mr.  Castroviejo  is general  partner of Paralax  LP, a Delaware
limited  partnership  ("Paralax LP").  International  Paralax and Paralax LP are
collectively referred to as the "Castroviejo  Entities." Mr. Castroviejo is also
a general partner, without management responsibility, of TC Management, the sole
general partner of Windsor LP.

                  The  business   address  and  the  address  of  the  principal
executive office of Mr. Apostolakis is c/o Lexington Shipping and Trading Corp.,
950 Third Avenue, 27th Floor, New York, New York 10022.


<PAGE>

                  The  business   address  and  the  address  of  the  principal
executive office of Mr. Ray is c/o Bannister's Wharf Co., Newport,  Rhode Island
02840.

                  The  business   address  and  the  address  of  the  principal
executive  office of Mr.  Marden is 1290 South Ocean Blvd,  Palm Beach,  Florida
33480.

                  The  business   address  and  the  address  of  the  principal
executive office of Mr. Campbell and Mr.  Castroviejo is c/o TC Management,  237
Park Avenue, Suite 800, New York, New York 10017.

                  (d) - (e) During the last five  years,  none of the  Reporting
Persons,  and,  to the best  knowledge  of the  Reporting  Persons,  none of the
Apostolakis  Entities,  Campbell  Entities  or  Castroviejo  Entities,  has been
convicted in a criminal  proceeding  (excluding  traffic  violations and similar
misdemeanors)  or has  been a  party  to a civil  proceeding  of a  judicial  or
administrative body of competent jurisdiction and as a result of such proceeding
was or is  subject  to a  judgment,  decree  or  final  order  enjoining  future
violations  of, or prohibiting  or mandating  activities  subject to, Federal or
state securities laws or finding any violation with respect to such laws.

                  (f) Each natural person identified in this Item 2 is a citizen
of the United States.



ITEM 3.           SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

                  As of July 14, 1998 the Reporting Persons  beneficially  owned
an aggregate of 2,873,700  shares of Common Stock, all of which were acquired on
the open market.  The costs of the purchases by Apostolakis  Entities,  Campbell
Entities and Castroviejo Entities were funded out of working capital, which may,
at any given time,  include margin loans made by brokerage firms in the ordinary
course of business.  The costs of the purchases made by the individual Reporting
Persons were funded out of personal funds, which may, at any given time, include
margin loans made by brokerage firms in the ordinary course of business.

ITEM 4.           PURPOSE OF TRANSACTION.

                  Each of the Reporting Persons+ or their affiliated entities is
a  substantial  and  long-time  shareholder  of the  Company.  Their  respective
acquisitions of Common Stock were originally made for investment purposes.

                  Over the  course of time,  certain  of the  Reporting  Persons
individually  have  expressed  to the  Company's  senior  executives  their very
serious  concerns with many aspects of the Company's  affairs,  including  among
other  things   management's   repeated  failure  to  meet  announced   business
expectations,

<PAGE>

enormous  increases in senior management  compensation,  the dramatic decline in
the  trading  price of the  Company's  Common  Stock,  and  reports  that senior
management is perceived by elements of the business and  financial  community as
lacking candor and credibility.

                  On July 6, 1998 Messrs. Apostolakis, Campbell, Castroviejo and
Knott met to share their  respective  views about the  Company's  situation  and
discuss what steps, if any, might be taken to further communicate those views to
the Company's  management and seek solutions to the Company's problems.  In view
of the issues  discussed at that meeting,  the matters on which the participants
concurred,  and the actions taken thereafter  (including the understanding  that
these persons and their  affiliates would share the cost of common legal counsel
in this connection), Messrs. Apostolakis, Campbell, Castroviejo and Knott may be
deemed to have formed a "group" for purposes of the  applicable  rules under the
Securities  Exchange Act, which is the occasion for filing the present  Schedule
13D. Subsequent  discussions with Messrs. Marden and Ray, who concurred with the
views of the others, led to their addition as Reporting Persons.

                  Following   the  July  6  meeting,   a  series  of   telephone
conversations were initiated among one or more of Messrs. Apostolakis,  Campbell
and Knott and one or both of the Company's Chairman and the Company's President.

                  As a  result  of  those  discussions,  the  Reporting  Persons
believed that an  understanding in principle had been reached with the Company's
senior  management  regarding  certain  immediate  steps to address  shareholder
concerns.  Those steps  included  (i) seeking to identify and employ in a senior
executive  capacity  an  individual  from  outside the  Company  with  extensive
pharmaceutical  industry  experience;  (ii) reducing recent  increases in senior
management  compensation  and basing  future  compensation  on  improvements  in
performance;   (iii)  finalizing  the  previously  indicated  departure  of  the
Company's  chief  operating  officer;  (iv)  re-allocating   responsibility  for
investor relations and  communications  with the financial  community,  possibly
with outside assistance;  and (v) reconfiguring the Company's Board of Directors
to retain four incumbent directors and, as the Reporting Persons understood,  to
add four new directors including Mr. Apostolakis.

                  At a  meeting  on  July  15 at  which  the  Reporting  Persons
expected to begin  implementing the foregoing  understanding  in principle,  the
Company's  Chairman,  while  apparently  still in agreement  with the first four
items noted  above,  maintained  that he had not agreed to the fifth  item,  and
proposed  a  significantly  different  Board  configuration  in which  incumbent
directors  would  continue to  constitute  a majority.  In the judgment of those
Reporting  Persons in attendance at that meeting,  the  Chairman's  proposal was
insufficient  to address the  Company's  situation and  inconsistent  with their
understanding of the parties' prior discussions.  Limited further communications
have not changed this view.


<PAGE>


                  The  Reporting   Persons  have   indicated  to  the  Company's
management that in the absence of an agreement  regarding  appropriate  steps to
address  the  Company's  problems,  they are  prepared  to seek  changes  in the
Company's  Board of  Directors  by other  means.  This  would  include,  without
limitation,  the  nomination of candidates for election to the Board at the next
meeting of the Company's shareholders.

                  Based on, among other things, the value of the Company's major
products,  Crinone and Replens,  its patented bio- adhesive  delivery system and
its extensive product pipeline, the Reporting Persons believe that the Company's
Common Stock is severely undervalued in the market. The Reporting Persons expect
that any  directors  who may be added to the Board  through  their efforts would
actively explore and pursue  alternatives to enhance  shareholder  value,  which
could  include a possible sale of the Company or other  extraordinary  corporate
transaction,  and would  retain  investment  bankers or other  advisers for that
purpose.

                  At any time, the Reporting  Persons may have  discussions with
investment  banking  firms or other  parties in an effort to identify  and fully
assess and evaluate potential  opportunities to realize and maximize shareholder
value.


ITEM 5.           INTEREST IN SECURITIES OF THE ISSUER.

                  (a)  The  Reporting  Persons  included  in this  Schedule  13D
beneficially own an aggregate of 2,873,900 shares of Common Stock,  representing
approximately 10.0% of the shares of the outstanding Common Stock./1/

                  Together   with  the   1,007,100   shares  of   Common   Stock
beneficially  owned by David  Knott as  reported  in a Schedule  13D  separately
filed,  the  members  of the  group  described  in  Item 4  beneficially  own an
aggregate of 13.5% of the shares of outstanding Common Stock.

                  The following  table sets forth the number of shares of Common
Stock  beneficially owned by each of the Reporting Persons and percentage of the
outstanding  Common  Stock  such  ownership  represents.  Item 2 sets  forth the
entities in which Mr. Campbell, Mr. Castroviejo and Mr. Apostolakis beneficially
own Common Stock.

- --------

/1/ Based upon  28,684,687  shares of Common Stock reported by the Company to be
outstanding as of April 30, 1998.


<PAGE>

<TABLE>
<CAPTION>

                                                                                           Percentage of
Reporting                                                 Shares of                         Outstanding
Person                                                  Common Stock                       Common Stock
- ------                                                  ------------                       ------------



<S>                                                       <C>                                   <C>
Mr. Apostolakis                                            868,800/2/                           3.0

Mr. Ray                                                    165,000                              0.6

Mr. Marden                                                 423,700                              1.5

Mr. Campbell                                              1,086,500                             3.8

Mr. Castroviejo/3/                                          330,000                             1.1

         The  following  table sets  forth the number of shares of Common  Stock
owned by the Apostolakis Entities.

                                                                                           Percentage of
Apostolakis                                              Shares of                          Outstanding
Entity                                                  Common Stock                       Common Stock

Lexington Corp.                                            48,600                               0.2

Bradmar Corp.                                              36,850                               0.1

Bradford Inc.                                              36,500                               0.1

Pension Plans                                              17,625                              0.06

</TABLE>

Additionally,  Mr. Apostolakis individually owns 724,225 shares of Common Stock,
representing approximately 2.5% of the outstanding Common Stock.

         The  following  table sets  forth the number of shares of Common  Stock
owned by the Campbell Entities.

<TABLE>
<CAPTION>
                                                                                           Percentage of
Campbell                                                  Shares of                         Outstanding
Entity/4/                                                 Common Stock                       Common Stock
- ---------                                                 ------------                       ------------

<S>                                                       <C>                                   <C>
TC Management                                             1,086,500                             3.8

Windsor LP                                                1,086,500                             3.8

</TABLE>
- --------

/2/ Not including certain non-qualified options, not presently  exercisable,  to
purchase 50,000 shares at a price of $11.625 granted on February 2, 1998.

/3/ Through his position as a general partner of TC Management, the sole general
partner of Windsor LP, Mr.  Castroviejo may also be deemed to  beneficially  own
shares of Common Stock, owned by Windsor LP, as to which he disclaims beneficial
ownership. The above table reflects only Mr. Castroviejo's position as president
of the manager of  International  Parallax  and general  partner of Parallax LP.
(see Item 2).

/4/  TC  Management,  as  general  partner  of  Windsor  LP,  may be  deemed  to
beneficially own the shares which Windsor LP directly owns.


<PAGE>

         The  following  table sets  forth the number of shares of Common  Stock
owned by the Castroviejo Entities.

<TABLE>
<CAPTION>
                                                                                           Percentage of
Castroviejo                                               Shares of                         Outstanding
Entity/5/                                                 Common Stock                       Common Stock
- ---------                                                 ------------                       ------------

<S>                                                        <C>                                  <C>
International Parallax                                     315,000                              1.1

Parallax LP                                                15,000                              0.05

</TABLE>

                  (b) By reason of his  position as sole  officer,  director and
shareholder of Lexington  Corp.,  Bradford Inc., and Bradmar  Corp.(see Item 2),
and his position as custodian  for the Pension  Plans,  Mr.  Apostolakis  may be
deemed to possess  the power to vote and  dispose of the shares of Common  Stock
beneficially  owned  by  the  Apostolakis  Entities.   Pursuant  to  Rule  13d-4
promulgated  under the  Securities  Act of 1934,  as  amended  (the  "Securities
Exchange Act"), Mr. Apostolakis disclaims beneficial ownership of such shares.

                  By reason of his  position as managing  general  partner of TC
Management,  the general  partner of Windsor LP (see Item 2) Mr. Campbell may be
deemed to possess  the power to vote and  dispose of the shares of Common  Stock
beneficially owned by the Campbell Entities.  Pursuant to Rule 13d-4 promulgated
under the Securities Exchange Act, Mr. Campbell disclaims  beneficial  ownership
of such shares.

                  By reason of his position as general partner of TC Management,
the general  partner of Windsor  LP, his  position  of  president  of manager of
International  Paralax and his  position  of general  partner of Paralax LP, Mr.
Castroviejo may be deemed to possess the power to vote and dispose of the shares
of Common Stock  beneficially owned by the Campbell Entities and the Castroviejo
Entities.  Pursuant to Rule 13d-4 promulgated under the Securities Exchange Act,
Mr. Castroviejo disclaims beneficial ownership of such shares.

                  (c)  Except as set forth on  Schedule  I annexed  hereto,  the
Reporting  Persons,  Apostolakis  Entities,  Campbell  Entities and  Castroviejo
Entities have not effected any  transactions in the Common Stock during the past
60 days. All such transactions were effected in the open market.

                  (d) Not applicable.

                  (e) Not applicable.

- --------

/5/ Mr.  Castroviejo  is also a general  partner of TC  Management,  the general
partner of Windsor LP. He may be deemed to beneficially  own the shares which TC
Management, Windsor LP and the Castroviejo Entities directly own.


<PAGE>

ITEM 6.           CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR
                  RELATIONSHIPS WITH RESPECT TO SECURITIES OF THE ISSUER.

                  Notwithstanding   certain   discussions   with  the  Company's
management,  there is no present understanding between the Reporting Persons and
the Company. (See item 4.)

ITEM 7.           MATERIAL TO BE FILED AS EXHIBITS.

                  Exhibit 1 -     Agreement of joint filing
                                  pursuant to Rule 13d(1)-f
                                  promulgated under the
                                  Securities Exchange Act of
                                  1934, as amended.


<PAGE>

                                   SIGNATURES


                  After reasonable  inquiry and to the best knowledge and belief
of the  undersigned,  the undersigned  certify that the information set forth in
this Statement is true, complete and correct.


Dated:  July 16, 1998



                                                 /s/ James J. Apostolakis
                                                 ------------------------
                                                 Name: James J. Apostolakis


                                                 /s/ David Ray
                                                 -------------
                                                 Name:  David Ray


                                                 /s/ Bernard Marden
                                                 ------------------
                                                 Name:  Bernard Marden



                                                 /s/ Anthony R. Campbell
                                                 -----------------------
                                                 Name: Tony Campbell



                                                 /s/ Christopher Castroviejo
                                                 ---------------------------
                                                 Name: Christopher Castroviejo


<PAGE>

                                                                      SCHEDULE I

                             TRANSACTIONS IN COMMON
                      STOCK OF COLUMBIA LABORATORIES, INC.
                          DURING THE PRECEDING 60 DAYS

Shares Purchased by James J. Apostolakis./6/

                                    Number of
                                    Shares
Date                                Purchased                    Total Cost
- ----                                ---------                    ----------

5/27/98                                  4200                     $35,265.00
7/8/98                                   1000                      $5,120.00
7/9/98                                   1100                      $6,946.00
7/13/98                                  1200                      $8,172.00

Shares Purchased by Lexington Corp.

                                    Number of
                                    Shares
Date                                Purchased                    Total Cost
- ----                                ---------                    ----------

7/13/98                                48,600                       $20,430

Shares Purchased by Bradmar Corp.

                                    Number of
                                    Shares
Date                                Purchased                    Total Cost
- ----                                ---------                    ----------

7/10/98                                  2000                     $14,500.00


Shares Purchased by Bernard Marden./7/

                                    Number of
                                    Shares
Date                                Purchased                    Total Cost
- ----                                ---------                    ----------

7/10/98                            55,400                        $387,800.00



- --------

/6/ In  addition  to the  listed  purchases,  on June 16,  1998 Mr.  Apostolakis
purchased 200 call options at $5.00 on the open market at a price of $1.625.

/7/ In addition to the listed purchases,  on June 18, 1998 Mr. Ray purchased 200
call options at $7.50 on the open market for a price of $.75.


<PAGE>


                                    EXHIBIT 1

                            Agreement of Joint Filing


                  Pursuant to 13d-1(f) promulgated under the Securities Exchange
Act of 1934, as amended,  the undersigned  persons hereby agree to file with the
Securities   and  Exchange   Commission  the  Statement  on  Schedule  13D  (the
"Statement")  to which this Agreement is attached as an exhibit,  and agree that
such Statement, as so filed, is filed on behalf of each of them.

                  IN  WITNESS  WHEREOF,   the  undersigned  have  executed  this
Agreement.


Dated:  July 16, 1998



                                                     /s/ James J. Apostolakis
                                                     ------------------------
                                                     Name:  James J. Apostolakis



                                                    /s/ David Ray
                                                    -------------
                                                    Name:  David Ray


                                                    /s/ Bernard Marden
                                                    ------------------
                                                    Name:  Bernard Marden



                                                    /s/ Anthony R. Campbell
                                                    -----------------------
                                                    Name: Tony Campbell



                                                   /s/ Christopher Castroviejo
                                                   ---------------------------
                                                   Name: Christopher Castroviejo




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