COLUMBIA LABORATORIES INC
SC 13D/A, 1998-12-16
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 FINAL AMENDMENT

                                (AMENDMENT NO. 4)
                                       to
                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934

                           Columbia Laboratories, Inc.
                           ---------------------------
                                (Name of Issuer)

                          Common Stock, $.01 par value
                          ----------------------------
                         (Title of Class of Securities)


                                    197779101
                                    ---------
                                 (CUSIP Number)


                              James J. Apostolakis
                    c/o Lexington Shipping and Trading Corp.
                          950 Third Avenue, 27th Floor
                            New York, New York 10022
                                 (212) 588-1900
                                 --------------
                     (Name, Address and Telephone Number of
                      Person Authorized to Receive Notices
                               and Communications)


                                December 14, 1998
                                -----------------
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box: |_|


<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101                      
- -------------------                      
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               James J. Apostolakis
- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a)  |X| *

                                                                      (b)  |_|
          * Disclaimed                                                   
- --------------------------------------------------------------------------------
3)      SEC USE ONLY

- --------------------------------------------------------------------------------
4)      SOURCE OF FUNDS

               PF,WC
- --------------------------------------------------------------------------------
5)      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
        TO ITEMS 2(d) OR 2(e)                                              |_|

- --------------------------------------------------------------------------------
6)      CITIZENSHIP OR PLACE OF ORGANIZATION

               United States
- --------------------------------------------------------------------------------
                         7)    SOLE VOTING POWER 
                               935,900 (See Item 5)

        NUMBER           -------------------------------------------------------
        OF               8)    SHARED VOTING POWER
        SHARES                 Not Applicable
        BENEFICIALLY     

                         -------------------------------------------------------
        OWNED BY         9)    SOLE DISPOSITIVE POWER
        EACH                   935,900 (See Item 5)
        REPORTING        

                         -------------------------------------------------------
        PERSON           10)   SHARED DISPOSITIVE POWER
        WITH                   Not Applicable

- --------------------------------------------------------------------------------
11)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               935,900 (See Item 5)

- --------------------------------------------------------------------------------
12)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
        SHARES                                                             |_|

- --------------------------------------------------------------------------------
13)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
               3.3%

- --------------------------------------------------------------------------------
14)     TYPE OF REPORTING PERSON
               IN
- ----------------------------------------------------------------



                                      - 2 -




<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101                       
- -------------------                       
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               David Ray

- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a)  |X| *

                                                                      (b)  |_|
          *Disclaimed
- --------------------------------------------------------------------------------
3)      SEC USE ONLY

- --------------------------------------------------------------------------------
4)      SOURCE OF FUNDS

               PF
- --------------------------------------------------------------------------------
5)      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
        TO ITEMS 2(d) OR 2(e)                                              |_|

- --------------------------------------------------------------------------------
6)      CITIZENSHIP OR PLACE OF ORGANIZATION

               United States
- --------------------------------------------------------------------------------

                         7)    SOLE VOTING POWER
                               214,000
        NUMBER           

                         -------------------------------------------------------
        OF               8)    SHARED VOTING POWER
        SHARES                 Not Applicable
        BENEFICIALLY     

                         -------------------------------------------------------
        OWNED BY         9)    SOLE DISPOSITIVE POWER
        EACH                   214,000
        REPORTING        

                         -------------------------------------------------------
        PERSON           10)   SHARED DISPOSITIVE POWER
        WITH                   Not Applicable

- --------------------------------------------------------------------------------
11)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               214,000

- --------------------------------------------------------------------------------
12)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
        SHARES                                                             |_|

- --------------------------------------------------------------------------------
13)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
               0.7%

- --------------------------------------------------------------------------------
14)     TYPE OF REPORTING PERSON
               IN
- -------------------------------------------------------------


                                      - 3 -




<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101  
- -------------------  
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               Bernard Marden

- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a)  |X| *

                                                                      (b)  |_|
          *Disclaimed

- --------------------------------------------------------------------------------
3)      SEC USE ONLY

- --------------------------------------------------------------------------------
4)      SOURCE OF FUNDS

               PF

- --------------------------------------------------------------------------------
5)      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
        TO ITEMS 2(d) OR 2(e)                                              |_|

- --------------------------------------------------------------------------------
6)      CITIZENSHIP OR PLACE OF ORGANIZATION

               United States

                         7)    SOLE VOTING POWER
                               375,000
        NUMBER           

                         -------------------------------------------------------
        OF               8)    SHARED VOTING POWER
        SHARES                 Not Applicable
        BENEFICIALLY     

                         -------------------------------------------------------
        OWNED BY         9)    SOLE DISPOSITIVE POWER
        EACH                   375,000
        REPORTING        

                         -------------------------------------------------------
        PERSON           10)   SHARED DISPOSITIVE POWER
        WITH                   Not Applicable

- --------------------------------------------------------------------------------
11)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               375,000

- --------------------------------------------------------------------------------
12)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
        SHARES                                                             |_|

- --------------------------------------------------------------------------------
13)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
               1.3 %

- --------------------------------------------------------------------------------
14)     TYPE OF REPORTING PERSON
               IN
- ----------------------------------------------------------------



                                      - 4 -




<PAGE>

                                  SCHEDULE 13D
CUSIP No. 197779101                       
- -------------------                       
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               Christopher Castroviejo

- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a)  |X| *

                                                                      (b)  |_|
          *Disclaimed

- --------------------------------------------------------------------------------
3)      SEC USE ONLY


- --------------------------------------------------------------------------------
4)      SOURCE OF FUNDS

               WC

- --------------------------------------------------------------------------------
5)      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
        TO ITEMS 2(d) OR 2(e)                                              |_|

- --------------------------------------------------------------------------------
6)      CITIZENSHIP OR PLACE OF ORGANIZATION

               United States

                         7)    SOLE VOTING POWER 
                               0 (See Item 5)
        NUMBER           
                         -------------------------------------------------------
        OF               8)    SHARED VOTING POWER
        SHARES                 Not Applicable
        BENEFICIALLY     

                         -------------------------------------------------------
        OWNED BY         9)    SOLE DISPOSITIVE POWER
        EACH                   0 (See Item 5)
        REPORTING        

                         -------------------------------------------------------
        PERSON           10)   SHARED DISPOSITIVE POWER
        WITH                   Not Applicable

- --------------------------------------------------------------------------------
11)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               0 (See Item 5)

- --------------------------------------------------------------------------------
12)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
        SHARES                                                             |_|

- --------------------------------------------------------------------------------
13)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
               0 %

- --------------------------------------------------------------------------------
14)     TYPE OF REPORTING PERSON
               IN
- ----------------------------------------------------------------



                                      - 5 -




<PAGE>

                                  Schedule 13D
                                  ------------


Item 1 of the  Schedule  13D,  "Security  and  Issuer,"  is amended to amend and
restate the first and second paragraphs thereof in their entirety as follows:

               This  Statement  amends the Schedule 13D dated July 16, 1998,  as
amended by Amendment  No. 1 filed on July 23, 1998,  by Amendment No. 2 filed on
October 6, 1998 and by Amendment No. 3 filed on November 11, 1998 (the "Schedule
13D"),  filed by James J.  Apostolakis  and the other  Reporting  Persons  named
therein relating to the Common Stock,  $.01 par value (the "Common  Stock"),  of
Columbia   Laboratories,   Inc.,  a  Delaware   corporation   (the   "Company").
Notwithstanding  this  Amendment No. 4, the Schedule 13D speaks as of this date.
Capitalized  terms used herein without  definition have the meanings assigned to
them in the Schedule 13D.

               In each  case,  the  filing of the  Schedule  13D and  Amendments
thereto does not constitute an admission that the Reporting Persons constitute a
"group" for purposes of the Securities  Exchange Act of 1934, as amended, or the
rules promulgated  thereunder or for any other purpose  whatsoever.  Each of the
Reporting Persons expressly disclaims  beneficial  ownership of any Common Stock
beneficially owned by any of the other Reporting Persons or any other person.

Item 2 (a) - (c) of the Schedule 13D,  "Identity and  Background," is amended to
amend and restate the second paragraph thereof in its entirety as follows:

               An aggregate of 1,524,900  shares of Common  Stock,  representing
approximately  5.3% of the shares of outstanding Common Stock, were beneficially
owned by the  various  Reporting  Persons  included in this  Schedule  13D as of
December  14,  1998.   An  aggregate  of  4,135,700   shares  of  Common  Stock,
representing approximately 14.4% of the shares of outstanding Common Stock, were
beneficially  owned by the various  Reporting  Persons included in this Schedule
13D together with Mr.  Anthony R.  Campbell  (who has filed a separate  Schedule
13D) and Mr. David Knott (who has filed a separate Schedule 13D), as of December
14, 1998.

Item 3 of the Schedule 13D, "Source and Amount of Funds or Other Consideration,"
is amended to amend and restate the first  sentence  thereof in its  entirety as
follows:

               As  of  December  14,  1998,   the  various   Reporting   Persons
beneficially  owned an  aggregate of 1,524,900  shares of Common  Stock,  all of
which were  acquired on the open market over the course of time at  then-current
prices for an aggregate consideration of approximately $32,554,101.


                                      - 6 -

<PAGE>

Item 4 of the Schedule 13D, "Purpose of Transaction," is amended to add the 
following:

               On December 14, 1998,  the Company  announced  that it planned to
restructure  its Board of  Directors  to include  three new  outside  directors,
including James J. Apostolakis,  one of the Reporting Persons.  The Company also
announced that it planned to hold its annual shareholders meeting on January 28,
1999, in New York City. The Company's  announcement followed discussions over an
extended  period of time with certain of the Reporting  Persons and others,  and
reflected,  among other things, the evolution of an understanding  regarding the
future  composition of the Board and certain related matters.  It is anticipated
that that understanding will be reflected in a definitive  agreement expected to
be  entered  into  shortly  between  the  Company,  certain  members  of  senior
management,  and  certain  of the  parties  who have been  Reporting  Persons or
otherwise referred to in the Schedule 13D and Amendments thereto.

               On the foregoing basis,  the Committee  described in the Schedule
13D is being  discontinued  and the Reporting  Persons and others referred to in
the Schedule 13D are no longer pursuing the matters discussed therein.

               It is anticipated that those persons who become  signatories to a
definitive  agreement  as noted above will make such  further  filings as may be
appropriate in that connection going forward.

Items 5 (a) and (c) of the Schedule 13D, "Interest in Securities of the Issuer,"
are amended and restated in their entirety as follows:

               (a)  An   aggregate  of   4,135,700   shares  of  Common   Stock,
representing approximately 14.4% of the shares of outstanding Common Stock, were
beneficially  owned by the various  Reporting  Persons included in this Schedule
13D together with Mr.  Anthony R.  Campbell  (who has filed a separate  Schedule
13D) and Mr. David Knott (who has filed a separate Schedule 13D), as of December
14, 1998.

               The  various  Reporting  Persons  included in this  Schedule  13D
beneficially own an aggregate of 1,524,900 shares of Common Stock,  representing
approximately 5.3% of the shares of outstanding Common Stock./1/

               An additional  1,138,200 shares of Common Stock,  representing an
additional  approximately  4.0% of the shares of outstanding  Common Stock, were
beneficially  owned by David Knott as of December 14, 1998  including  1,303,200
shares  reported in a Schedule 13D separately  filed and an aggregate of 165,000
shares of Common Stock sold since that filing.

               An additional  1,472,600 shares of Common Stock,  representing an
additional  approximately  5.1% of the shares of outstanding  Common Stock, were
beneficially owned by Anthony R.


- -------------------
/1/ Based upon  28,684,687 shares of Common  Stock  reported by the Company to 
be outstanding as of October 31, 1998.


                                      - 7 -

<PAGE>

Campbell as of December 14, 1998, reported in a Schedule 13D separately filed.

         The  following  table sets  forth the number of shares of Common  Stock
beneficially  owned by each of the Reporting  Persons/2/ as of December 14, 1998
and the percentage of the  outstanding  Common Stock such ownership  represents.
Item 2 sets forth the entities  which own Common Stock of which Mr.  Apostolakis
may be deemed the beneficial owner.

                                                           Percentage of
Reporting                       Shares of                   Outstanding
Person                        Common Stock                 Common Stock
- ------                        ------------                 ------------

Mr. Apostolakis                 935,900/3/                      3.3

Mr. Ray                          214,000                        0.7

Mr. Marden                       375,000                        1.3


        The  following  table sets  forth the  number of shares of Common  Stock
owned by the Apostolakis Entities as of December 14, 1998.

                                                            Percentage of
Apostolakis                     Shares of                    Outstanding
Entity                         Common Stock                 Common Stock
- ------                         ------------                 ------------

Lexington Corp.                   70,500                         0.2

Bradmar Corp.                     51,850                         0.2

Bradford Inc.                     50,400                         0.2

Pension Plans                     17,625                         0.06

         Additionally,  Mr.  Apostolakis  individually  owns  745,525  shares of
Common Stock, representing approximately 2.6% of the outstanding Common Stock.

         As previously reported, Mr. Castroviejo and the Castroviejo Entities no
longer hold any shares of Common Stock.  Mr.  Castroviejo has ceased to have any
involvement in the matters discussed in the Schedule 13D.


- --------------------
/2/ As previously reported, Mr. Castroviejo and the Castroviejo Entities no 
longer hold any shares of Common Stock.  Mr.  Castroviejo has ceased to have any
involvement in the matters discussed in the 13D. (See Item 2.)

/3/ Not including certain non-qualified  options, not presently  exercisable, to
purchase 50,000 shares at a price of $11.625 granted on February 2, 1998.



                                      - 8 -




<PAGE>

        Each of the Reporting Persons expressly disclaims  beneficial  ownership
of any Common Stock  beneficially owned by any of the other Reporting Persons or
any other person.

        (c) Except as set forth on  Schedule  I annexed  hereto,  the  Reporting
Persons,  Apostolakis  Entities and  Castroviejo  Entities have not effected any
transactions in the Common Stock during the past 60 days. All such  transactions
were effected in the open market.

Item  6  of  the  Schedule  13D,  "Contracts,  Arrangements,  Understandings  or
Relationships  with Respect to  Securities of the Issuer," is amended to add the
following:

         It is anticipated that the understanding  referred to in Item 4 will be
reflected in a definitive  agreement expected to be entered into shortly between
the Company,  certain  members of senior  management,  the Reporting  Person and
certain  of the  parties  who have  been  referred  to in the  Schedule  13D and
Amendments thereto. (See Item 4.)


                                      - 9 -

<PAGE>

                                   SIGNATURES
                                   ----------


               After reasonable  inquiry and to the best knowledge and belief of
the undersigned,  the undersigned certify that the information set forth in this
Statement is true, complete and correct.


Dated:  December 15, 1998



                                                        /s/ James J. Apostolakis
                                                        ------------------------
                                                     Name:  James J. Apostolakis


                                                                   /s/ David Ray
                                                                   -------------
                                                                Name:  David Ray


                                                              /s/ Bernard Marden
                                                              ------------------
                                                           Name:  Bernard Marden


                                                     /s/ Christopher Castroviejo
                                                     ---------------------------
                                                         Christopher Castroviejo



                                     - 10 -




<PAGE>

         SCHEDULE I IS AMENDED AND RESTATED IN ITS ENTIRETY AS FOLLOWS:


                                   SCHEDULE I


                             TRANSACTIONS IN COMMON
                      STOCK OF COLUMBIA LABORATORIES, INC.
                          DURING THE PRECEDING 60 DAYS



Shares Purchased by James J. Apostolakis:

                                    Number of
                                     Shares
Date                                Purchased                      Total Cost
- ----                                ---------                      ----------

10/15/98                                4,000                         $10,955
10/20/98                                6,000                          21,055
10/21/98                                3,400                          12,225
10/26/98                               10,000                          38,755
10/27/98                                5,000                          18,317.50
10/28/98                                8,000                          26,467.50
10/29/98                               15,000                          48,880
11/02/98                                8,000                          29,360
11/16/98                                4,000                          17,455
11/18/98                                1,000                           3,940
11/23/98                                  500                           1,941
11/23/98                                  500                           1,998

Shares Purchased by Bradford Inc.:

                                    Number of
                                     Shares
Date                                Purchased                        Total Cost
- ----                                ---------                        ----------

10/15/98                                2,000                          $5,500
10/20/98                                2,000                           7,375
10/27/98                                1,000                           3,752.50
10/29/98                                1,500                           4,950
11/27/98                                2,300                           9,199
11/30/98                                2,000                           7,750
12/14/98                                3,600                          10,800




                                     - 11 -




<PAGE>

Shares Purchased by Lexington Corp.:

                                    Number of
                                     Shares
Date                                Purchased                       Total Cost
- ----                                ---------                       ----------
                                     
10/15/98                               2,000                          $ 5,500
10/20/98                               3,000                           11,217.50
10/21/98                               1,000                            3,627.50
10/26/98                               2,000                            7,375.50
10/27/98                               2,000                            7,500
10/28/98                               2,000                            6,875
10/29/98                               4,000                           13,205
11/2/98                                2,500                            9,500
11/18/98                               2,000                            8,105


Shares Sold By Bradmar Inc.:

                                    Number of
                                     Shares
Date                                Purchased                        Total Cost
- ----                                ---------                        ----------

12/03/98                              3,500                            $12,945
12/03/98                              1,000                              3,700
12/03/98                              1,500                              5,550

Shares Purchased by Mr. Ray:

                                    Number of
                                     Shares
Date                                Purchased                        Total Cost
- ----                                ---------                        ----------

10/26/98                              24,100                           $85,600
10/27/98                               3,900                            13,650



Shares Purchased by Mr. Marden:

                                    Number of
                                     Shares
Date                                Purchased                        Total Cost
- ----                                ---------                        ----------

10/16/98                              50,000                          $150,000



                                     - 12 -




<PAGE>



Shares Sold by Mr. Marden:

                                    Number of
                                     Shares
Date                                  Sold                           Total Cost
- ----                                  ----                           ----------


12/3/98                             16,000                             $56,000
12/4/98                             17,400                              58,725
12/8/98                              2,000                               6,625
12/8/98                              8,000                              26,000
12/11/98                            55,300                             183,043



                                     - 13 -






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