CYTEL CORP/DE
DEF 14A, 1998-04-30
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
                            SCHEDULE 14A INFORMATION
                   Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934

Filed by the Registrant                              [X]
Filed by a Party other than the Registrant           [ ]

Check the appropriate box:

[ ]  Preliminary Proxy Statement

[ ]  Confidential, for Use of the Commission Only (as permitted by Rule
     14a-6(e)(2))

[X]  Definitive Proxy Statement

[ ]  Definitive Additional Materials

[ ]  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12

                                Cytel Corporation
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
     (Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box)

[X]  No fee required.

[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     1.   Title of each class of securities to which transaction applies:

          ----------------------------------------------------------------------

     2.   Aggregate number of securities to which transaction applies:

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     3.   Per unit price or other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
          filing fee is calculated and state how it was determined):

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     4.   Proposed maximum aggregate value of transaction:

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     5.   Total fee paid:

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[ ]  Fee paid previously with preliminary materials.

[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     1.   Amount Previously Paid:

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     2.   Form, Schedule or Registration Statement No.:

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     3.   Filing Party:

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     4.   Date Filed:

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<PAGE>   2
                                CYTEL CORPORATION
                             3525 JOHN HOPKINS COURT
                               SAN DIEGO, CA 92121


To Our Stockholders:

        We have enclosed with this letter the proxy materials for our upcoming
Annual Meeting, including detailed descriptions of two stock plan proposals and
an option repricing proposal. We are asking for your approval of these proposals
to allow us to attract, retain and motivate highly qualified employees, and by
doing so, to enhance the value of the Company on behalf of all stockholders of
the Company.

Proposed Option Repricing

        Although option programs are critical incentive tools, when stock prices
fall, these programs can amplify the challenge of restoring stockholder values.
Employees are demoralized by the loss of their expected profits, and retention
value disappears. If stock prices drop well below exercise prices, employees who
are not financially sophisticated will consider the options to be worthless - in
spite of favorable long-term prospects for their companies.

        When companies experience a substantial decline in stock price, their
Boards of Directors may be asked to reprice (i.e. lower the exercise prices of)
employee stock options which have lost their near-term compensation value. On
April 28, 1998, the closing price of the Company's Common Stock was $1.71 per
share. Of the Company's approximately 4,600,000 options outstanding under the
Company's 1989 Stock Option Plan, over 900,000 options have an exercise price in
excess of $6.00 per share and over 2,400,000 have an exercise price of $4.00 per
share or higher. As a result, the exercise price that most Cytel employees would
have to pay in order to exercise their stock options substantially exceeds the
price at which anyone could buy stock in the market. We believe that such
"out-of-the-money" stock options have little incentive value to employees and in
fact undermine morale and motivation.

        In December 1996, the Board of Directors agreed at the request of the
State of Wisconsin Investment Board, a major shareholder of the Company (the
"Wisconsin Board"), not to reprice any options prior to December 1998 without
prior stockholder approval. We are concerned that the Company may be at risk of
losing employees because most of the outstanding stock options are not providing
incentives to the Company's management team and other employees. After careful
consideration of market conditions, employee turnover, employee morale and the
challenges and opportunities facing the Company, the Board of Directors has
determined that it is in the best interests of the stockholders of the Company
to give employees the opportunity to consider replacing "underwater" stock
options with options having an exercise price equal to the fair market value of
the stock on the date of exchange. The decision to do so requires balancing two
apparently conflicting points of view:

o       FOR EMPLOYEES repricing is viewed as a good thing. Repricing restores
        value to options which were offered as inducement to join the company
        and which have been earned by employees through vesting. A standardized
        repricing formula allows employees to decide for themselves whether to
        accept the terms of the repricing. Moreover, it alleviates the problem
        of deciding on new option grants which must be designed to meet each
        employee's individual option situation (i.e. depending on exercise
        prices and vesting status of previous grants, as well as eligibility for
        future grants). For management, repricing is inherently equitable; it is
        easy to implement without disrupting compensation administration, and it
        can quickly solve serious problems of employee motivation and retention.

o       FOR STOCKHOLDERS repricing is viewed as a bad thing. Stockholders
        approve stock option programs on the basis that employees can
        participate in the upside valuation potential of the stock, if they
        accept the risk of receiving zero compensation when the upside does not
        materialize. Since stockholders do not receive a partial refund when
        stock prices decline, they justifiably consider it unfair to provide
        this benefit to employees - in particular the senior management team
        responsible for building shareholder value. For stockholders, repricing
        can violate the basic rationale for stock options.


<PAGE>   3

        How can this conflict be resolved? The answer is in devising a repricing
proposal that restores motivational value from an employee viewpoint without
providing a windfall gain from a stockholder viewpoint.

        Employees and stockholders tend to view the present value of stock
options in very different ways:

o       EMPLOYEES usually focus on the cash value of stock options. In their
        view, the cash value is simply the difference between the option
        exercise price and the current (or expected near-term) stock market
        price, times the number of vested shares (i.e. "how much would my
        options be worth to me if I cash them in"). Most employees tend to
        relate their stock options to tangible compensation benefits, e.g.
        buying a new car, financing a house, or paying for college. As a result,
        most employees would choose to have fewer options that are exercisable
        at the current market price, rather than more options that are
        exercisable at well above the current market price.

o       STOCKHOLDERS usually focus on the investment value of stock options. In
        their view this investment value is determined by the dilution effect of
        selling stock below the market, which is a cost that can be quantified
        using the Black-Scholes option model. As a result, most stockholders
        would not object to lowering exercise prices if the Black-Scholes
        fair value of the option grants did not change - a result that
        can be achieved by lowering the number of option shares by an
        appropriate amount.

        This difference in valuation perceptions offers a way to design an
effective and acceptable option repricing proposal: revise the parameters of
stock option contracts to restore near-term cash value to employees without
changing the investment value of these contracts for stockholders. In other
words, offer employees the opportunity to benefit from lower exercise prices by
accepting a smaller number of option shares calculated to maintain the fair
value of each option contract before and after repricing.

        In light of the Company's current position, the Board of Directors has
worked closely with the Wisconsin Board to develop an option exchange program,
the details of which are described in Proposal 3 and summarized below, that is
acceptable to the Wisconsin Board and which aligns the interests of stockholders
and employees. We believe that the Company is at a critical stage in its
development and that the option exchange program will be critical to employee
retention.

        The proposed option exchange program would offer Cytel employees,
including management, a one-time opportunity to exchange their out-of-the-money
stock options for fewer new options exercisable at the market price of the
Company's Common Stock when the exchange is made. The exchange ratio will be
calculated based on a mathematical formula which incorporates components of the
Black-Scholes option model, including the exercise price of the previous option
s and new options, and the volatility and price of the Company's Common Stock
at the date of award of the new options. The formula was developed by a
third-party mathematical modeling consulting firm employed by the Wisconsin
Board. These same components and formula were used to develop a unique vesting
feature for the new options that encourages employees to hold their options. The
mechanism used to accomplish this is a deferral of vesting of portions of the
option until the sixth year following the date of exchange if an employee
exercises the option relatively soon after the exchange.

        Cytel and the Wisconsin Board believe that both employees and
shareholders benefit from this program, which attempts to equalize the
Black-Scholes fair value before and after repricing regardless of how long the
options are held. Employees are offered an opportunity to hold stock options
which they perceive to be of greater near-term incentive value, and receive a
greater portion of the options if they continue to hold as employees.
Shareholders can view the repricing as a relatively neutral financial
transaction in terms of its impact on dilution as measured by the Black-Scholes
fair value. We have designed the exchange program in consultation with the
Wisconsin Board, and your Board of Directors, management and the Wisconsin Board
recommend approval of the repricing proposal.

Increase In Employee Stock Pool

        The Company's long-term incentive compensation program includes stock
options and other stock awards and an employee stock purchase plan. Stock
options are an important component of employee compensation for biotechnology
companies. When stock prices rise, in-the-money stock options can provide
significant compensation 

<PAGE>   4

without using essential cash resources, and the unvested portions of those
options provide incentives to stay, thereby raising recruiting costs to
competitive employers. Virtually all companies in the biotechnology industry use
stock options to attract and retain outstanding employees, and there is
substantial competition to obtain and/or retain skilled and experienced
scientists and managers in the industry. Many biotechnology companies also offer
cash bonuses to their employees, but Cytel does not. As a result, stock
option-based incentives are a particularly important part of the benefits
package for employees of the Company.

        Because a stock option only becomes exercisable if an employee remains
with the Company, stock options are an important means of motivating employees
to remain at Cytel. As stock options become fully exercisable and are exercised,
their impact in motivating employees and directors dissipates, and it becomes
necessary to grant new stock options to those employees and directors. Proposal
5 provides for amendments to the Company's 1989 Option Plan and 1994
Non-Employee Directors' Plan to increase the number of shares available for
issuance under such plans. At present, the Company has only 185,144 shares
available for option grants to be used to attract new employees or as incentives
to retain current employees. The Company currently anticipates that the
additional shares for which approval is being requested should be sufficient to
satisfy the Company's equity incentive needs until its annual meeting in the
year 2000.

        We want to assure you that we are very sensitive to the dilutive nature
of stock options. In this regard, it is our policy over the long term to
constrain annual increases in the employee stock option pool to not exceed 2.5%
of the total outstanding Common Stock on average.

        In this context we have given very careful consideration to how we
should update our option program in light of recent events and future
challenges. Because we believe you understand the critical role that properly
designed stock options play in attracting, motivating, and retaining the
employee talent necessary to develop important new medicines, your Board of
Directors and management recommend approval of the proposed increase in the
employee stock option and purchase plan pools.

Sincerely,

/s/ HOWARD E. GREENE, JR.

Howard E. Greene, Jr.
Chairman of the Board

<PAGE>   5
                                CYTEL CORPORATION
                             3525 JOHN HOPKINS COURT
                               SAN DIEGO, CA 92121

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON JUNE 12, 1998

    NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of Cytel
Corporation, a Delaware corporation (the "Company"), will be held on Friday,
June 12, 1998 at 1:30 p.m. at 3525 John Hopkins Court, San Diego, California,
for the following purposes:

    1.  To elect nine directors to hold office for the ensuing year or until
        their successors are elected.

    2.  To approve an amendment to the Company's Amended and Restated
        Certificate of Incorporation to increase the Company's authorized shares
        of Common Stock from 50,000,000 shares to 75,000,000 shares.

    3.  To approve an option exchange program.

    4.  To approve an amendment to the Company's Employee Stock Purchase Plan to
        provide that the aggregate number of shares of Common Stock authorized
        for issuance will be 750,000 (an increase of 250,000 shares from 500,000
        shares previously authorized under the Employee Stock Purchase Plan).

    5.  To approve amendments to the Company's 1989 Option Stock Plan (the "1989
        Plan") and the Company's 1994 Non-Employee Directors' Stock Option Plan
        (the "Non-Employee Directors' Plan") to provide that the aggregate
        number of shares of Common Stock authorized for issuance on a combined
        basis under both the Company's 1989 Stock Plan and the Non-Employee
        Directors' Plan will be 7,750,000 shares (an increase of 1,350,000
        shares from 6,400,000 shares previously authorized under the 1989 Plan
        and the Non-Employee Directors' Plan).

    6.  To ratify the selection of Ernst & Young LLP, as independent auditors of
        the Company for the year ending December 31, 1998.

    7.  To transact such other business as may properly come before the meeting
        or any adjournment or postponement thereof.

    The foregoing items of business are more fully described in the Proxy
Statement accompanying this Notice.

    The Board of Directors has fixed the close of business on April 18, 1998 as
the record date for the determination of stockholders entitled to notice of and
to vote at this Annual Meeting and at any adjournment or postponement thereof.

                                       By Order of the Board of Directors

                                       /s/ EDWARD C. HALL
                                       ----------------------------------------
                                       Edward C. Hall
                                       Vice President, Finance, Chief Financial 
                                         Officer and Secretary

San Diego, California
May __, 1998

    ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.
WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN AND
RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR
REPRESENTATION AT THE MEETING. A RETURN ENVELOPE (WHICH IS POSTAGE PREPAID IF
MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE. EVEN IF YOU HAVE
GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE
NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER
NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST OBTAIN FROM THE RECORD
HOLDER A PROXY ISSUED IN YOUR NAME.

<PAGE>   6
                                CYTEL CORPORATION
                             3525 JOHN HOPKINS COURT
                               SAN DIEGO, CA 92121

                                 PROXY STATEMENT

                 INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

         The enclosed proxy is solicited by the Board of Directors of Cytel
Corporation, a Delaware corporation (the "Company" or "Cytel"), for use at the
Annual Meeting of Stockholders to be held on Friday, June 12, 1998 at 1:30 p.m.
(the "Annual Meeting"), or at any adjournment or postponement of that meeting,
for the purposes set forth herein and in the foregoing Notice of Annual Meeting.
The Annual Meeting will be held at the Company's headquarters, 3525 John Hopkins
Court, San Diego, California, 92121. The Company intends to mail this proxy
statement and accompanying proxy card on or about May 4, 1998 to all
stockholders entitled to vote at the Annual Meeting.

SOLICITATION

         The entire cost of solicitation of proxies, including expenses in
connection with preparing and mailing this Proxy Statement, the proxy and any
additional information furnished to the stockholders will be borne by the
Company. Copies of solicitation materials will be furnished to banks, brokerage
houses, nominees, fiduciaries and custodians holding in their names shares of
Common Stock beneficially owned by others to forward to such beneficial owners.
The Company may reimburse persons representing beneficial owners of Common Stock
for their costs in forwarding solicitation materials to such beneficial owners.
Original solicitation of proxies by mail may be supplemented by telephone,
telegram and personal solicitation by directors, officers or other regular
employees of the Company. No additional compensation will be paid to directors,
officers or other regular employees for such services.

VOTING RIGHTS AND OUTSTANDING SHARES

         Only holders of record of the Company's Common Stock and Series B
Convertible Preferred Stock (the "Series B Preferred Stock") at the close of
business on April 18, 1998 will be entitled to notice of and to vote at the
Annual Meeting. At the close of business on April 17, 1998, the Company had
outstanding and entitled to vote 32,867,887 shares of Common Stock. Each holder
of record of Common Stock on such date will be entitled to one vote for each
share held on all matters to be voted upon at the Annual Meeting. At the close
of business on April 17, 1998, the Company had outstanding 659,898 shares of
Series B Preferred Stock held by G.D. Searle & Co. ("Searle"). Based upon a
formula set forth in the Company's Certificate of Designation of the Series B
Preferred Stock, 66,135 shares of Series B Preferred Stock held by Searle are
entitled to vote. Searle will be entitled to .788 of a vote for each share of
Series B Preferred Stock entitled to vote on all matters to be voted upon at
the Annual Meeting.

         All votes will be tabulated by the inspector of election appointed
for the meeting, who will separately tabulate affirmative and negative votes,
abstentions and broker non-votes. Abstentions will be counted towards the
tabulation of votes cast on proposals presented to the stockholders and will
have the same effect as negative votes. Except for Proposal 2, broker non-votes
are counted towards a quorum but are not counted for any purpose in determining
whether a matter has been approved. With respect to Proposal 2, abstentions and
broker non-votes will have the same effect as negative votes.

REVOCABILITY OF PROXIES

         Any stockholder giving a proxy pursuant to this solicitation has the
power to revoke it any time before it is voted. It may be revoked by filing with
the Secretary of the Company at the Company's principal executive office, 3525
John Hopkins Court, San Diego, California, 92121, a written notice of revocation
or a duly executed proxy bearing a later date. It may also be revoked by
attending the meeting and voting in person. Attendance at the meeting will not,
by itself, revoke a proxy.


                                       1.

<PAGE>   7

STOCKHOLDER PROPOSALS

         Proposals of stockholders that are intended to be presented at the
Company's 1999 Annual Meeting of Stockholders must be received by the Company no
later than January 4, 1999 in order to be included in the proxy statement and
proxy relating to that Annual Meeting.

                                   PROPOSAL 1

                              ELECTION OF DIRECTORS

         The Company's directors are elected annually to serve until the next
Annual Meeting and until each such director's successor shall have been duly
elected and qualified or until such director's earlier death, resignation or
removal. There are nine nominees for the nine Board positions presently
authorized in the Company's By-laws. Each nominee listed below is currently a
director of the Company, eight such directors having been elected by the
stockholders and one director, Nancy Rasmussen, having been appointed by the
Board.

         Shares represented by executed proxies will be voted for the election
of the nominees named below, unless the proxy is marked in such a manner as to
withhold authority to vote for any of them. In the event any nominee becomes
unable or unwilling to serve, the shares represented by the enclosed proxy will
be voted for the election of the balance of those named and such substitute
nominee as the Board of Directors may select. The Board of Directors has no
reason to believe that any nominee will be unable or unwilling to serve.

         Directors are elected by a plurality of the votes present in person or
represented by proxy and entitled to vote at the meeting.

                      MANAGEMENT AND THE BOARD OF DIRECTORS
                   RECOMMEND A VOTE IN FAVOR OF EACH NOMINEE.

NOMINEES

         The names of the nominees and certain information about them are set
forth below:

<TABLE>
<CAPTION>
                                                              PRINCIPAL OCCUPATION/POSITION
             NAME                   AGE                            HELD WITH THE COMPANY
             ----                   ---                       -----------------------------
<S>                                 <C>     <C>
Howard E. Greene, Jr.               55      Director and founder of Amylin Pharmaceuticals, Inc. and Chairman
                                            of the Board of Directors

Virgil Thompson                     58      President, Chief Executive Officer and Director

Robert L. Roe, M.D., F.A.C.P.       57      Executive Vice President, Chief Operating Officer and Director

James C. Paulson, Ph.D.             50      Vice President, Chief Scientific Officer, General Manager,
                                            Glytec(TM) and Director

David L. Anderson                   54      Managing Director, Sutter Hill Ventures/Director

William T. Comer, Ph.D.             62      President and Chief Executive Officer of SIBIA Neurosciences,
                                            Inc./Director

Nicole Vitullo                      40      Senior Vice President, Rothschild Asset Management Ltd./Director

David L. Mahoney                    43      Group President, Pharmaceutical Services and International Group,
                                            McKesson Corporation/Director

Nancy D. Rasmussen                  39      Vice President, Global New Business Franchise, G.D. Searle & Co./Director
</TABLE>

         Mr. Greene, a founder of the Company, has served as a director since
the Company's inception. He was elected Chairman of the Board in January 1989
and served as President from July 1987 to January 1989. Mr. Greene 


                                       2.
<PAGE>   8

is a director and founder of Amylin Pharmaceuticals, Inc., a biotechnology
company involved in research and development of medicines for treating diabetes
and served as Chairman of the Board from 1987 to 1998. He was a general partner
of Biovest Partners, a seed venture capital firm specializing in medical
technology companies from 1986 until 1993. Prior to Biovest, he was Chief
Executive Officer of Hybritech Incorporated, a biotechnology company acquired by
Eli Lilly & Company in 1986. Mr. Greene is a director of Allergan Incorporated,
Neurex Corporation, Biosite Diagnostics Incorporated and International
Biotechnology Trust plc.

         Mr. Thompson has served as a director and as President and Chief
Executive Officer since January 1996. From July 1994 to December 1995, he was
President and Chief Executive Officer of CIBUS Pharmaceutical, Inc. ("CIBUS"), a
drug delivery company. For the 25 years preceding his employment with CIBUS, he
was employed by Syntex Corporation, most recently as President, Syntex
Laboratories, Inc. Mr. Thompson is a director of Biotechnology General
Corporation, Cypros Pharmaceutical Corporation and Aradigm Corporation.

         Dr. Roe has served as a director and as Executive Vice President and
Chief Operating Officer since January 1996. During 1995, Dr. Roe was Executive
Vice President and Chief Operating Officer of Chugai Biopharmaceuticals, Inc.
("Chugai"), a biopharmaceutical company. Prior to joining Chugai, Dr. Roe was
employed by Syntex Corporation from 1976 to 1995, most recently as President,
Development Research Division and as Senior Vice President.

         Dr. Paulson has served as a director and as Vice President since
January 1991. He has been employed by Cytel in various positions since September
1990, most recently as Vice President and General Manager, Glytec(TM). He has
also been an adjunct member of The Scripps Research Institute since July 1990.
From 1985 to July 1990, Dr. Paulson served as a Professor and Vice Chair of the
Department of Biological Chemistry at the University of California School of
Medicine-Los Angeles.

         Mr. Anderson has been a director of the Company since May 1988. He has
been managing director or general partner of the general partner of Sutter Hill
Ventures, a California Limited Partnership ("Sutter Hill"), a venture capital
investment firm, since 1974. Mr. Anderson is also a director of Dionex
Corporation, Neurex Corporation, BroadVision, Inc., and Molecular Devices
Corporation.

         Dr. Comer has served as a director of the Company since January 1994.
He has been President and Chief Executive Officer of SIBIA Neurosciences, Inc.
("SIBIA"), a biotechnology company, since April 1991. Prior to joining SIBIA,
Dr. Comer held various positions at Bristol-Myers Squibb, a pharmaceutical
company, from September 1961 to March 1991, most recently as Senior Vice
President, Strategic Management, Pharmaceuticals and Nutritionals, from 1990 to
1991. Dr. Comer is a member of the Board of Directors of SIBIA.

         Ms. Vitullo has served as a director of the Company since January 1995.
Ms. Vitullo has been with Rothschild Asset Management Ltd. ("Rothschild") since
November 1992, most recently serving as Senior Vice President. Rothschild
advises and manages two publicly traded biotechnology funds: Biotechnology
Investments Limited and International Biotechnology Trust plc. From July 1991 to
November 1992, Ms. Vitullo was Director of Corporate Communications and Investor
Relations at Cephalon Inc. ("Cephalon"), a neuropharmaceutical company. Prior to
Cephalon, she spent 12 years with the Eastman Kodak Company, most recently as
Manager, Healthcare Investments. Ms. Vitullo is also a member of the Board of
Directors of Anergen, Inc., Cadus Pharmaceuticals, Corvas International and Onyx
Pharmaceuticals.

         Mr. Mahoney has served as a director of the Company since September
1996. He has been Group President, Pharmaceutical Services and International
Group, McKesson Corporation ("McKesson") since September 1997 and served as
President of Pharmaceutical and Retail Services, McKesson from August 1996 to
August 1997. Mr. Mahoney served as President of Healthcare Delivery System
("HDS") from September 1994 until December 1995, and as Vice President of
strategic planning at McKesson from July 1990 to September 1994. Prior to
joining McKesson, he was a principal with McKinsey & Company in San Francisco.

         Ms. Rasmussen has served as a director of the Company since March 1998.
She has been with G.D. Searle & Co. ("Searle") since 1985, most recently as Vice
President, Global New Business Franchise. Ms. Rasmussen's 


                                       3.
<PAGE>   9

responsibilities include membership on Searle's Priority Committee, Operations
Management Team and Portfolio Steering Committee. She is active in management of
Searle's collaborations serving on the Board of Directors of Lorex, a joint
venture with Synthelabo, and the executive committee of Co-Sensys.

COMMITTEES AND MEETINGS

         During the fiscal year ended December 31, 1997, the Board of Directors
held eleven meetings. The standing committees of the Board of Directors include
an Audit Committee, a Compensation Committee and an Executive Committee. The
Board does not have a nominating committee or committee performing similar
functions.

         The Audit Committee is comprised of Mr. Greene and Dr. Comer, neither
of whom is an employee of the Company. During 1997, the Audit Committee held one
meeting. The Audit Committee recommends the independent auditors to the Board
and provides a direct line of communication between the auditors and the Board.
The independent auditors separately meet with the Audit Committee, with and
without Company management present, to review and discuss various matters,
including the Company's financial statements, the report of the independent
auditors on the results, scope and terms of their work and their recommendations
concerning the Company's financial practices and procedures.

         The Compensation Committee is comprised of Messrs. Greene, Anderson and
Mahoney, none of whom are employees of the Company. This Committee, which held
four meetings during 1997, administers the Company's stock option plans, stock
purchase plan and 401(k) plan, approves salaries, bonuses and other compensation
arrangements for the Company's officers and performs such other functions
regarding compensation as the Board may delegate.

         The members of the Executive Committee are Messrs. Anderson, Greene and
Thompson. The Executive Committee did not hold any meetings during 1997. This
Committee was established to act when the full Board of Directors is
unavailable. It has all the authority of the Board in the management of the
business and affairs of the Company, except those powers that by law cannot be
delegated by the Board of Directors.

         During the fiscal year ended December 31, 1997, each director attended
at least 75% of the meetings of the Board of Directors and the committees on
which he served during such period.


                                       4.
<PAGE>   10

                                   PROPOSAL 2

                 APPROVAL OF THE COMPANY'S AMENDED AND RESTATED
                    CERTIFICATE OF INCORPORATION, AS AMENDED

         The Board of Directors has adopted, subject to stockholder approval, an
amendment to the Company's Amended and Restated Certificate of Incorporation
(the "Amended and Restated Certificate") to increase the authorized number of
shares of Common Stock from 50,000,000 shares to 75,000,000 shares (the
"Amendment").

         As of March 13, 1998, there were 32,859,887 shares of Common Stock
outstanding and 659,898 shares of Series B Preferred Stock outstanding. In
addition, the Board has reserved 6,400,000 shares of Common Stock for issuance
upon exercise of options and rights granted under the Company's stock option
plans, and 500,000 shares for issuance under the Company's Employee Stock
Purchase Plan. In addition, the Board has approved an increase of an additional
1,600,000 shares reserved under such plans as described in Proposals 4 and 5.

         The additional Common Stock to be authorized by adoption of the
Amendment would have rights identical to the currently outstanding Common Stock
of the Company. Adoption of the Amendment and issuance of the Common Stock would
not affect the rights of the holders of currently outstanding Common Stock of
the Company, except for effects incidental to increasing the number of shares of
the Company's Common Stock outstanding such as dilution of the earnings per
share and percentage share of voting rights of current holders of Common Stock.
If the Amendment is adopted, it will become effective upon filing of a
Certificate of Amendment of the Company's Amended and Restated Certificate with
the Secretary of State of the State of Delaware.

         The Board believes that the availability of such additional shares will
provide the Company with increased flexibility to use its capital stock for
business and financial purposes in the future. The additional shares may be
used, without further stockholder approval, for various purposes including,
without limitation, raising capital, providing equity incentives to employees,
officers or directors, establishing strategic relationships with other companies
and expanding the Company's business or service offerings through the
acquisition of other businesses.

         The additional shares of Common Stock that would become available for
issuance if the proposal were adopted could also be used by the Company to
oppose a hostile takeover attempt or delay or prevent changes in control or
management of the Company. For example, without further stockholder approval,
the Board could strategically sell shares of Common Stock in a private
transaction to purchasers who would oppose a takeover or favor the current
Board. Although this proposal to increase the authorized Common Stock has been
prompted by business and financial considerations and not by the threat of any
hostile takeover attempt (nor is the Board currently aware of any such attempts
directed at the Company), nevertheless, stockholders should be aware that
approval of this proposal could facilitate future efforts by the Company to
deter or prevent changes in control of the Company, including transactions in
which the stockholders might otherwise receive a premium for their shares over
then current market prices.

         Under the Company's Amended and Restated Certificate, no stockholder is
entitled to preemptive rights with respect of any future issuances of capital
stock. In addition, the Company does not presently contemplate seeking
stockholder approval for any future issuances of capital stock unless required
to do so by an obligation imposed by applicable law, a regulatory authority or a
third party.

         The affirmative vote of the holders of a majority of the shares
entitled to vote will be required to approve this amendment to the Company's
Amended and Restated Certificate of Incorporation. As a result, abstentions and
broker nonvotes will have the same effect as negative votes.

                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 2.


                                       5.
<PAGE>   11
                                   PROPOSAL 3

                       APPROVAL OF OPTION EXCHANGE PROGRAM

        In December 1996, the Board of Directors agreed at the request of the
State of Wisconsin Investment Board, a major stockholder of the Company (the
"Wisconsin Board"), not to reprice any options without prior stockholder
approval until December 1998. In light of the Company's current position, the
Board of Directors has worked closely with the Wisconsin Board to develop an
option exchange program, the details of which are described below, that the
Board of Directors in good faith believes is in the best interests of the
Company's stockholders and that is acceptable to the Wisconsin Board. The Board
of Directors has approved the option exchange program, subject to stockholder
approval. In addition, the Wisconsin Board has advised the Company that it
intends to vote in favor of this proposal.

        The Board of Directors believes that the Company is at a very important
stage in its development. During the past several years in general, and the past
year in particular, there have been a number of significant developments at the
Company and a number of important changes for its employees. We now have
underway a multi-center Phase II/III clinical study with Cylexin designed to
show a therapeutic benefit in ischemia/reperfusion injury in infants undergoing
cardiopulmonary bypass associated with open heart surgery to correct
life-threatening congenital heart defects. We are actively pursuing many
opportunities to use our proprietary enzymatic synthesis technology for
manufacturing bioactive carbohydrates for use in pharmaceuticals, nutritionals
and other products. Further, in October 1997, the Company funded its subsidiary,
Epimmune Inc. ("Epimmune"), and transferred certain patents, fixed assets and
approximately 25 employees associated with Cytel's immune stimulation program to
Epimmune. In light of the various developments described above, the Board of
Directors believes that it is of critical strategic importance to motivate
management and employees to remain at the Company and provide an incentive for
them to exert maximum efforts on behalf of the Company and its stockholders.

        The market price for the Company's Common Stock has declined
significantly in recent years from over $9.00 per share, putting many employees'
options underwater. During the last four quarters, the closing price of the
Company's Common Stock has ranged between $1.38 and $2.81 per share. On April
28, 1998, the closing price of the Company's Common Stock was $1.71 per share.
Of the Company's approximately 4,600,000 options outstanding under the Company's
1989 Stock Option Plan at April 28, 1998, over 900,000 options have an exercise
price in excess of $6.00 per share and over 2,400,000 have an exercise price of
$4.00 per share or higher. Accordingly, the exercise price that most employees
would have to pay in order to exercise their stock options substantially exceeds
the current price of $1.71 at which anyone could buy stock in the market. The
Board of Directors believes that such "out-of-the-money" stock options have
little incentive value to employees and in fact undermine morale and motivation.
In addition, virtually all companies in the biotechnology industry use stock
options to attract and retain outstanding employees, and there is substantial
competition to obtain and/or retain skilled and experienced scientists and
managers in the industry. Many biotechnology companies also offer cash bonuses
to its employees, but Cytel does not. Accordingly, stock option-based
performance incentives are a particularly important part of a competitive
overall compensation package for employees of the Company.

        The Board of Directors is concerned that the Company may be at risk of
losing valued employees because most of the outstanding stock options are not
providing incentives to the Company's management team and other employees. After
careful consideration of market conditions, employee turnover, employee morale
and the challenges and opportunities facing the Company, the Board of Directors
believes that this situation is likely to be more damaging to the Company and
its stockholders than the effect of an option exchange program. As a result, in
the good faith judgment of the Board of Directors, it is in the best interests
of the stockholders of the Company to replace "underwater" stock options with
options having an exercise price equal to the current fair market value of the
stock, thus restoring the opportunity for employees to receive value in the near
term by building the Company and causing the market value of the stock to
increase.

        The Company has worked closely with the Wisconsin Board to structure the
option exchange program in such a manner as to align the interests of
stockholders and employees as closely as possible. The principal components of
the option exchange program, including the unique exchange ratio and vesting
features it incorporates, are described below.


                                       6.
<PAGE>   12
        The proposed option exchange program would allow members of management
and other employees a one-time opportunity to exchange their outstanding
out-of-the-money stock options for fewer new options at the market price of the
Company's Common Stock at the time of the exchange. Outside or non-executive
directors of the Company will not be eligible to participate in the option
exchange program. The exchange ratio for the new options will be calculated
based on a mathematical formula which incorporates components of the
Black-Scholes option model, including the exercise price of the previous options
and new options, and the volatility and price of the Company's Common Stock at
the date of award of the new options. The formula was developed by a third-party
mathematical modeling consulting firm employed by the Wisconsin Board. Using the
formula, the exchange ratio will be lower for current options with higher
exercise prices. For example, a current option to purchase 100,000 shares of
Common Stock with an exercise price of $6.125 per share could be exchanged for a
new option to purchase 85,120 shares of Common Stock, while a current out-of-the
money option to purchase 100,000 shares of Common Stock with an exercise price
of $12.00 per share could be exchanged for a new option to purchase 75,560
shares of Common Stock. Shares of Common Stock reserved for issuance under old
options in excess of the amount exchanged for new options will not be returned
to the pool of shares available for issuance under the Company's 1989 Plan.

        A critical component of the proposed option exchange program is the
unique vesting features applicable to new options. The Company's existing stock
options typically vest over a four-year period. All of the shares subject to the
new stock options will vest fully over a six-year period. The mathematical
formula described above will be used to determine the vesting schedule for each
new option. Accordingly, the vesting schedule will be dependent upon the
exercise price of the old option.

        The table below illustrates both the exchange ratios for repriced
options relative to the range of exercise prices of out-of the-money options
currently held by Cytel's employees and the unique vesting features. The year 6
line in the table reflects the exchange ratios for the new options with an
assumed exercise price of $1.625 per share that replaces old options with
specified exercise prices. The various percentages listed opposite the other
years reflect the maximum number of shares (as a percentage of the old option)
available for exercise in the specified year. The table will be revised in
accordance with the Black-Scholes option valuation model if the exercise price
of the new option (market price at time of award of the new option) is different
than $1.625.

             NEW OPTION EXCHANGE RATIO AS PERCENTAGE OF OLD OPTIONS

<TABLE>
<CAPTION>
Original Option Price       $2.688      $4.00      $5.50       $6.125      $7.50      $12.00
                            ------      -----      -----       ------      -----      ------
          Year
          ----
<S>                         <C>         <C>        <C>         <C>         <C>         <C> 
           1                 67.72       45.64      31.29       27.19       20.50       9.66
           2                 81.40       66.55      55.12       51.42       44.75      31.06
           3                 87.59       77.07      68.43       65.50       60.04      47.79
           4                 91.16       83.40      76.81       74.52       70.17      59.95
           5                 93.46       87.59      82.49       80.70       77.24      68.88
           6                 95.04       90.52      86.54       85.12       82.37      75.56
</TABLE>


        As set forth in the table above, the number of shares available for
exercise in year 1 is lower for new options that were exchanged for old options
at higher prices. For example, an optionee that exchanges an option to purchase
100,000 shares of Common Stock with an exercise price of $2.688 per share will
be vested in 67,720 shares at the end of the first year. An optionee that
exchanges an option to purchase 100,000 shares of Common Stock with an exercise
price of $12.00 per share will be vested in only 9,660 shares at the end of the
first year. The formula has been developed with the goal of aligning both the
exchange ratio and the vesting schedule with the economic benefit received by
the employee.

        In addition, each new option will be subject to special exercise
provisions that can limit the number of shares available for exercise. If an
optionee exercised the total vested portion of his option prior to the end of
the six-year period, the remaining shares subject to the option will not vest
until year six. If the optionee exercises a 


                                       7.
<PAGE>   13

portion of the vested shares prior to the end of the six-year period, a portion
of the shares (based on the percentage of the vested portion exercised) will not
vest until year six. The remaining portion of the shares otherwise available for
exercise as of that date will continue to vest according to the mathematical
progression of the formula. The Company and the Wisconsin Board believe that
these exercise and exchange ratios may provide an incentive for the optionee to
exercise stock options later during the option term than would occur with one of
the Company's current options and therefore benefit the stockholders of the
Company.

        The price of the new stock options will be set at the fair market value
of the Company's Common Stock on the date of exchange. If this Proposal 3 is
approved by the stockholders of the Company, the Board of Directors intends to
authorize the repricing immediately following the Annual Meeting, with an
approximate effective date of June 30, 1998.

        The affirmative vote of the holders of a majority of the shares present
in person or represented by proxy and entitled to vote at the meeting will be
required to approve the option exchange program. Abstentions will be counted
toward the tabulation of votes counted and will have the same effect as negative
votes, while broker non-votes will not be counted for any purpose in determining
whether this matter has been approved. The Wisconsin Board has advised the
Company that it intends to vote in favor of this Proposal.

                        THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 3.



                                       8.
<PAGE>   14

                                   PROPOSAL 4

            APPROVAL OF THE EMPLOYEE STOCK PURCHASE PLAN, AS AMENDED

         In October 1991, the Board of Directors adopted and the stockholders
subsequently approved the Employee Stock Purchase Plan (the "Purchase Plan")
authorizing the issuance of 200,000 shares of the Company's Common Stock. As a
result of one amendment, there were 500,000 shares of Common Stock reserved for
issuance under the Purchase Plan. The Purchase Plan provides a means by which
employees of the Company and its affiliates may purchase Common Stock of the
Company at a discount through accumulated payroll deductions. At December 31,
1997, an aggregate of 452,334 shares had been issued under the Purchase Plan,
and only 47,666 shares remained available for the grant of future rights under
the Purchase Plan. On March 13, 1998, the Board of Directors adopted an
amendment to the Purchase Plan, subject to stockholder approval, to increase the
number of shares authorized for issuance under the Purchase Plan, from 500,000
shares to 750,000 shares. At March 13, 1998, there remained an aggregate of
1,603 shares available for grant under the Purchase Plan. This amendment affords
the Company greater flexibility in providing employees with stock incentives and
ensures that the Company can continue to provide such incentives at levels
determined appropriate by the Compensation Committee.

         Stockholders are requested in this Proposal 4 to approve the Purchase
Plan, as amended. The affirmative vote of the holders of a majority of the
shares present in person or represented by proxy and entitled to vote at the
meeting will be required to approve the Purchase Plan, as amended. Abstentions
will be counted toward the tabulation of votes counted and will have the same
effect as negative votes, while broker non-votes will not be counted for any
purpose in determining whether this matter has been approved.

                        THE BOARD OF DIRECTORS RECOMMENDS
                          A VOTE IN FAVOR OF PROPOSAL 4.

         The essential features of the Purchase Plan, as amended, are outlined
below:

PURPOSE

         The purpose of the Purchase Plan is to provide a means by which
employees of the Company (and any parent or subsidiary of the Company designated
by the Board of Directors to participate in the Purchase Plan) may be given an
opportunity to purchase Common Stock of the Company through payroll deductions,
without payment of broker commissions, at a discounted price and upon terms
which offer certain tax advantages.

         The rights to purchase Common Stock granted under the Purchase Plan are
intended to qualify as options issued under an "employee stock purchase plan" as
that term is defined in Section 423(b) of the Internal Revenue Code of 1986, as
amended (the "Code").

ADMINISTRATION

         The Purchase Plan is administrated by the Board of Directors, which has
the final power to construe and interpret the Purchase Plan and the rights
granted under it. The Board has the power, subject to the provisions of the
Purchase Plan, to determine when and how rights to purchase Common Stock of the
Company will be granted, the provisions of each offering of such rights (which
need not be identical), and whether any parent or subsidiary of the Company
shall be eligible to participate in such plan and to construe and interpret the
Plan and rights granted under it, and to establish, amend and revoke rules and
regulations for its administration. The Board has the power, which it has not
exercised, to delegate administration of such plan to a committee of not less
than two Board members. The Board has delegated administration of the Purchase
Plan to the Compensation Committee of the Board. As used herein with respect to
the Purchase Plan, the "Board" refers to the Compensation Committee, as well as
to the Board of Directors itself. The Board may abolish any such committee at
any time and revest in the Board to administration of the Purchase Plan.


                                       9.
<PAGE>   15

OFFERINGS

         The Purchase Plan is implemented by offerings of rights to all eligible
employees from time to time by the Board. Generally, each such offering is of
two years duration.

ELIGIBILITY

         Any person who is customarily employed at least 20 hours per week and
five months of the calendar year by the Company (or by any parent or subsidiary
of the Company designated from time to time by the Board) on the first day of an
offering period is eligible to participate in that offering under the Purchase
Plan, provided such employee is employed by the Company on the offering date.

         Notwithstanding the foregoing, no employee is eligible for the grant of
any rights under the Purchase Plan if, immediately after such grant, the
employee would own, directly or indirectly, stock possessing 5% of more of the
total combined voting power or value of all classes of stock of the Company or
of any parent or subsidiary of the Company (including any stock which such
employee may purchase under all outstanding rights and options), nor will any
employee be granted rights that would permit him to buy more than $25,000 worth
of stock (determined at the fair market value of the shares at the time such
rights are granted) under all employee stock purchase plans of the Company in
any calendar year.

PARTICIPATION IN THE PLAN

         Eligible employees become participants in the Purchase Plan by
delivering to the Company, prior to the date selected by the Board as of the
offering date for the offering, an agreement authorizing payroll deductions of
up to 12% of such employees' base compensation during the purchase period.

PURCHASE PRICE

         The purchase price per share at which shares are sold in an offering
under the Purchase Plan cannot be less than the lower of (a) 85% of the fair
market value of a share of Common Stock on the date of commencement of the
offering, or (b) 85% of the fair market value of a share of Common Stock on the
exercise date.

PAYMENT OF PURCHASE PRICE; PAYROLL DEDUCTIONS

         The purchase price of the shares is accumulated by payroll deductions
over the offering period. At any time during the purchase period, a participant
may reduce or terminate his or her payroll deductions. A participant may not
increase or begin such payroll deductions after the beginning of any offering
period. All payroll deductions made for a participant are credited to his or her
account under the Purchase Plan and deposited with the general funds of the
Company. A participant may not make any additional payments into such account.

PURCHASE OF STOCK

         By executing an agreement to participate in the Purchase Plan, the
employee is entitled to purchase shares under such plan. In connection with
offerings made under the Purchase Plan, the Board specifies a maximum number of
shares any employee may be granted the right to purchase and the maximum
aggregate number of shares which may be purchased pursuant to such offering by
all participants. If the aggregate number of shares to be purchased upon
exercise of rights granted in the offering would exceed the maximum aggregate
number, the Board would make a pro rata allocation of shares available in a
uniform and equitable manner. Unless the employee's participation is
discontinued, his right to purchase shares is exercised automatically at the end
of the offering period at the applicable price. See "Withdrawal" below.


                                      10.
<PAGE>   16

WITHDRAWAL

         While each participant in the Purchase Plan is required to sign an
agreement authorizing payroll deductions, the participant may withdraw from a
given offering by terminating his or her payroll deductions and by delivering to
the Company a notice of withdrawal from the Purchase Plan. Such withdrawal may
be elected at any time prior to 10 days before an exercise date.

         Upon withdrawal from an offering by the employee, the Company will
distribute to the employee his or her accumulated payroll deductions without
interest, and such employee's interest in the offering will be automatically
terminated. The employee is not entitled to again participate in such offering.
An employee's withdrawal from an offering will not have any effect upon such
employee's eligibility to participate in subsequent offerings under the Purchase
Plan.

TERMINATION OF EMPLOYMENT

         Rights granted pursuant to any offering under the Purchase Plan
terminate immediately upon cessation of an employee's employment for any reason,
and the Company will distribute to such employee all of his or her accumulated
payroll deductions, without interest.

RESTRICTIONS OF TRANSFER

         Rights granted under the Purchase Plan are not transferable and may be
exercised only by the person to whom such rights are granted.

DURATION, AMENDMENT AND TERMINATION

         The Board may suspend or terminate the Purchase Plan at any time.
Unless terminated earlier, such plan will terminate on August 1, 2001.

         The Board may amend the Purchase Plan at any time. Any amendment of the
Purchase Plan must be approved by the stockholders within 12 months of its
adoption by the Board if the amendment would (a) increase the number of shares
of Common Stock reserved for issuance under the Purchase Plan, (b) modify the
requirements relating to eligibility for participation in the Purchase Plan, or
(c) modify any other provision of the Purchase Plan in a manner that would
materially increase the benefits accruing to participants under the Purchase
Plan, if such approval is required in order to comply with the requirements of
Rule 16b-3 under the Securities Exchange Act of 1934, as amended (the "Exchange
Act").

         Rights granted before amendment or termination of the Purchase Plan
will not be altered or impaired by any amendment or termination of such plan
without consent of the person to whom such rights were granted.

EFFECT OF CERTAIN CORPORATE EVENTS

         In the event of a dissolution, liquidation or specified type of merger
of the Company, the surviving corporation either will assume the rights under
the Purchase Plan or substitute similar rights, or the exercise date of any
ongoing offering will be accelerated such that the outstanding rights may be
exercised immediately prior to, or concurrent with, any such event.

STOCK SUBJECT TO PURCHASE PLAN

         If rights granted under the Purchase Plan expire, lapse or otherwise
terminate without being exercised, the Common Stock not purchased under such
rights again becomes available for issuance under such plan.


                                      11.
<PAGE>   17

FEDERAL INCOME TAX INFORMATION

         The following is only a summary of the effect of federal income
taxation upon the participant and the Company with respect to the rights granted
under the Purchase Plan. This summary does not purport to be complete and does
not discuss the income tax laws of any state or foreign country in which a
participant may reside. Rights granted under the Purchase Plan are intended to
qualify for favorable federal income tax treatment associated with rights
granted under an employee stock purchase plan which qualifies under provisions
of Section 423 of the Code. A participant will be taxed on amounts withheld for
the purchase of shares as if such amounts were actually received. Other than
this, no income will be taxable to a participant until disposition of the shares
acquired, and the method of taxation will depend upon the holding period of the
purchase shares.

         If the stock is disposed of at least two years after the beginning of
the offering period and at least one year after the stock is transferred to the
participant, then the lesser of (i) the excess of the fair market value of the
stock at the time of such disposition over the exercise price or (ii) the excess
of the fair market value of the stock as of the beginning of the offering period
over the exercise price (determined as of the beginning of the offering period)
will be treated as ordinary income. Any further gain or any loss will be taxed
as a long-term capital gain or loss if the stock is held for more than 18
months, and as a mid-term capital gain or loss if the stock is held for more
than 12 months and less than 18 months and one day. Capital gains currently are
subject to lower tax rates than ordinary income. The maximum long-term capital
gains rate for federal income tax purposes is currently 20% and the maximum 
mid-term capital gains rate is 28% while the maximum ordinary income rate is
effectively 39.6% at the present time.

         If the stock is sold or disposed of before the expiration of either of
the holding periods described above, then the excess of the fair market value of
the stock on the exercise date over the exercise price generally will be treated
as ordinary income at the time of such disposition, and the Company may, in the
future, be required to withhold income taxes relating to such ordinary income
from other payments made to the participant. The balance of any gain will be
treated as capital gain. Even if the stock is later disposed of for less than
its fair market value on the exercise date, the same amount of ordinary income
is attributed to the participant, and a capital loss is recognized equal to the
difference between the sales price and the fair market value of the stock on
such exercise date. Any capital gain or loss realized by a participant upon the
disposition of stock acquired under the Purchase Plan will be long-term,
mid-term or short-term depending on the length of time the stock has been held.

         There are no federal income tax consequences to the Company by reason
of the grant or exercise of rights under the Purchase Plan. The Company is
entitled to a deduction to the extent amounts are taxed as ordinary income to a
participant (subject to the requirement of reasonableness, the provisions of
Section 162(m) of the Code and the satisfaction of a tax reporting obligation).


                                      12.
<PAGE>   18

                                   PROPOSAL 5

             APPROVAL OF THE 1989 STOCK OPTION PLAN, AS AMENDED AND
                  RESTATED AND THE 1994 NON-EMPLOYEE DIRECTORS'
                          STOCK OPTION PLAN, AS AMENDED

         In October 1991, the Board of Directors adopted and the stockholders
subsequently approved, the Company's 1989 Stock Option Plan as amended and
restated (the "1989 Plan"). In March 1994, the Board of Directors adopted, and
the stockholders subsequently approved, the Company's 1994 Non-Employee
Directors' Stock Option Plan (the "Non-Employee Directors' Plan"). As a result
of a series of amendments, there were 6,400,000 shares of Common Stock reserved
for issuance on a combined basis under the 1989 Plan and the Non-Employee
Directors' Plan (collectively, the "Plans") on December 31, 1997.

         At December 31, 1997, options (net of canceled or expired options)
covering an aggregate of 5,385,009 shares of the Company's Common Stock had been
granted under the Plans, of which 1,600,854 shares have been exercised and
3,784,155 shares remain outstanding on a combined basis under the Plans. As a
result, only 1,014,991 shares (plus any shares that might in the future be
returned to the Plans as a result of cancellations or expiration of options)
remained available for future grant on a combined basis under the Plans. As of
March 13, 1998, only 185,144 shares (plus any shares that might in the future be
returned to the plans as a result of cancellations or expiration of options)
remained available for future grant on a combined basis under the Plans.

         On March 13, 1998, the Board approved amendments to the Plans, subject
to stockholder approval, to increase the number of shares authorized for
issuance on a combined basis under the Plans from 6,400,000 to 7,750,000 shares.
The Board adopted these amendments to ensure that the Plans have sufficient
shares reserved to allow for future automatic grants under such Plans.

         Stockholders are requested in this Proposal 5 to approve the Plans, as
amended. The affirmative vote of the holders of a majority of the shares present
in person or represented by proxy and voting at the meeting will be required to
approve the Plans, as amended. Abstentions will be counted toward the tabulation
of votes counted and will have the same effect as negative votes, while broker
non-votes will not be counted for any purpose in determining whether this matter
has been approved.

                      MANAGEMENT AND THE BOARD OF DIRECTORS
                    RECOMMEND A VOTE IN FAVOR OF PROPOSAL 5.

                    DESCRIPTION OF THE 1989 STOCK OPTION PLAN

         The essential features of the Company's 1989 Plan are outlined below.

GENERAL

         The 1989 Plan provides for the grant of both incentive and nonstatutory
stock options and the issuance of Common Stock pursuant to stock purchase
agreements and stock bonuses (collectively, "Stock Awards"). Incentive stock
options granted under the 1989 Plan are intended to qualify as "incentive stock
options" within the meaning of the Code. Nonstatutory stock options granted
under the 1989 Plan are not intended to qualify as incentive stock options under
the Code. See "Federal Income Tax Information" for a discussion of the tax
treatment of incentive and nonstatutory stock options.

PURPOSE

         The 1989 Plan was adopted to provide a means by which selected
employees and directors of and consultants and advisors to the Company and its
affiliates could be given an opportunity to benefit from increases in value of
the Common Stock of the Company through the granting of Stock Awards, to assist
in retaining the 


                                      13.
<PAGE>   19

services of persons holding key positions, to secure and retain the services of
persons capable of filling such positions and to provide incentives for such
persons to exert maximum efforts for the success of the Company.

ADMINISTRATION

         The 1989 Plan is administered by the Board of Directors of the Company.
The Board has the power to construe and interpret the 1989 Plan and subject to
the provisions of the 1989 Plan, to determine: the persons to whom Stock Awards
will be granted; when and how Stock Awards will be granted; whether a Stock
Award will be an incentive stock option, a nonstatutory stock option, a stock
bonus, a right to purchase stock or a combination of the foregoing; the
provisions of each Stock Award granted, including the time or times when a
person will be permitted to receive stock pursuant to a Stock Award; and the
number of shares with respect to which Stock Awards will be granted to each
person. The Board of Directors is authorized to delegate administration of the
1989 Plan to a committee composed of not fewer than two members of the Board.
The Board has delegated administration of the 1989 Plan to the Compensation
Committee of the Board. As used herein with respect to the 1989 Plan, the
"Board" refers to the Compensation Committee as well as to the Board of
Directors itself.

         The proposed regulations under Section 162(m) (described more fully in
the section entitled "Federal Income Tax Information" below) also provide that
the directors who may serve as members of the Compensation Committee must be
"outside directors." The Company currently intends to limit the directors who
may serve as members of the Compensation Committee to those who are "outside
directors." This limitation excludes from the Compensation Committee (i) current
employees of the Company, (ii) former employees of the Company receiving
compensation for past services (other than benefits under a tax-qualified
pension plan), (iii) current and former officers of the Company, and (iv)
directors currently receiving compensation from the Company for personal
services (other than as a director).

ELIGIBILITY

         Incentive stock options may be granted under the 1989 Plan only to
employees (including officers) of the Company and its affiliates. Stock Awards
other than incentive stock options may be granted under the 1989 Plan only to
employees (including officers) and directors of and advisors and consultants to
the Company or its affiliates.

         No incentive stock option may be granted under the 1989 Plan to any
person who, at the time of the grant, owns (or is deemed to own) stock
possessing more than 10% of the total combined voting power of the Company or
any affiliate of the Company, unless the option exercise price is at least 110%
of the fair market value of the stock subject to the option on the date of
grant, and the term of the option does not exceed five years from the date of
grant. For incentive stock options granted under the 1989 Plan, the aggregate
fair market value, determined at the time of grant, of the shares of Common
Stock with respect to which such options are exercisable for the first time by
an optionee during any calendar year (under all such plans of the Company and
its affiliates) may not exceed $100,000.

STOCK SUBJECT TO THE 1989 PLAN

         Stock subject to the 1989 Plan may be unissued shares or reacquired
shares, bought on the market or otherwise. If any Stock Award granted under the
1989 Plan expires or otherwise terminates without being exercised in full, the
Common Stock not purchased pursuant to such Stock Award shall again become
available for issuance under the 1989 Plan.

TERMS OF OPTIONS

         The following is a description of the permissible terms of options
under the 1989 Plan. Individual option grants may be more restrictive as to any
or all of the permissible terms described below.

         Exercise Price; Payment. The exercise price of incentive stock options
under the 1989 Plan may not be less than 100% of the fair market value of the
Common Stock subject to the option on the date of the option grant, 


                                      14.
<PAGE>   20

and in some cases (see "Eligibility" above) may not be less than 110% of such
fair market value. The exercise price of nonstatutory options under the 1989
Plan may not be less than 85% of the fair market value of the Common Stock
subject to the option on the date of the option grant. The Board has the
authority to offer employees the opportunity to have outstanding options
repriced or to replace outstanding higher priced options, whether incentive or
nonstatutory, with new lower priced options. At March 13, 1998, the closing
price of the Company's Common Stock as reported on the Nasdaq National Market
System was $2.28.

         The exercise price of options granted under the 1989 Plan must be paid
either: (i) in cash at the time the option is exercised; or (ii) at the
discretion of the Board at the time the option is granted or exercised, either
(a) by delivery of other Common Stock of the Company, (b) pursuant to a deferred
payment arrangement or (c) in any other form of legal consideration acceptable
to the Board.

         Transferability. Under the 1989 Plan, an option may not be transferred
by the optionee other than by will or by the laws of descent and distribution.
During the lifetime of an optionee, an option may be exercised only by the
optionee.

     Option Exercise. Options granted under the 1989 Plan may become exercisable
in cumulative increments ("vest") as determined by the Board. Shares covered by
currently outstanding options under the 1989 Plan typically vest 25% at the end
of the first year of the optionee's employment or service as a director, advisor
or consultant and thereafter daily at the rate of 25% per year during such
period of employment or service. Shares covered by options granted in the future
under the 1989 Plan may be subject to different vesting terms. The Board has the
power to accelerate the time during which an option may be exercised. In 1998,
the Company implemented a performance management system (the "Performance
Management System") for members of certain employee teams organized under the
Performance Management System. Under the Performance Management System, options
are subject to acceleration of vesting upon the achievement of certain
performanced-based objectives by such teams.

     In addition, options granted under the 1989 Plan may permit exercise prior
to vesting, but in such event the optionee may be subject to a repurchase right
in favor of the Company with respect to shares not yet vested (which repurchase
right would typically be at the exercise price), should the optionee leave the
employ of the Company before vesting. To the extent provided by the terms of an
option, an optionee may satisfy any federal, state or local tax withholding
obligation relating to the exercise of such option by a cash payment upon
exercise, by authorizing the Company to withhold a portion of the stock
otherwise issuable to the optionee, by delivering already-owned stock of the
Company or by a combination of these means.

         Term. The maximum term of options under the 1989 Plan is ten years,
except that in certain cases (see "Eligibility") the maximum term is five years.
Options under the 1989 Plan terminate three months after the optionee's
termination of employment with or relationship as a director, advisor or
consultant to the Company or any affiliate of the Company, unless (i) the
termination of employment or relationship is due to such person's permanent and
total disability (as defined in the Code), in which case the option may, but
need not, provide that it may be exercised at any time within six months of such
termination; (ii) the optionee dies while employed by or serving as a director,
advisor or consultant to the Company or any affiliate of the Company, or within
not more than three months after termination of such employment or service, in
which case the option may, but need not, provide that it may be exercised (to
the extent the option was exercisable at the time of the optionee's death)
within six months of the optionee's death by the person or persons to whom the
rights to such option pass by will or by the laws of descent and distribution;
or (iii) the option by its terms specifically provides otherwise. The 1989 Plan
provides that, in the event that holder of an option or other stock award is
permitted to take a leave of absence, the Company has the unilateral right to
determine whether such leave of absence will be treated as a termination of
employment or other relationship or to suspend or otherwise delay the time at
which exercisability or vesting would otherwise occur with respect to any
outstanding option or other stock award.

TERMS OF STOCK BONUSES AND RESTRICTED STOCK

         The following is a description of the permissible terms of stock
bonuses and purchases of restricted stock under the 1989 Plan. Individual stock
bonuses or purchases of restricted stock may be more restrictive as to any or
all of the permissible terms described below.


                                      15.
<PAGE>   21

         Purchase Price; Payment. The purchase price for restricted stock shall
be determined by the Board. The Board may determine that eligible participants
may be awarded stock pursuant to a stock bonus agreement in consideration for
past services rendered to the Company.

         The purchase price of stock acquired pursuant to a restricted stock
purchase agreement must be paid either (i) in cash at the time of purchase; (ii)
at the discretion of the Board, according to a deferred payment arrangement; or
(iii) in any other form of legal consideration acceptable to the Board.

         Repurchase Option. Shares of Common Stock sold or awarded under the
1989 Plan may, but need not, be subject to a repurchase option in favor of the
Company in accordance with a vesting schedule to be determined by the Board. In
the event a person ceases to be an employee of, or an advisor, consultant or
director to, the Company, the Company may repurchase or otherwise reacquire any
or all of the unvested Common Stock held by that person on the date of
termination, if provided for pursuant to the terms of the stock bonus or
restricted stock purchase agreement.

         Transferability. No rights under a stock bonus or restricted stock
purchase agreement may be assigned by any participant under the 1989 Plan,
except where such assignment is required by law or expressly authorized by the
terms of the applicable stock bonus or restricted stock purchase agreement.

ADJUSTMENT PROVISIONS

         If there is any change in the stock subject to the 1989 Plan or subject
to any Stock Award granted under the 1989 Plan (through merger, consolidation,
reorganization, recapitalization, stock dividend, dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares, change in corporate structure or otherwise), the 1989 Plan and Stock
Awards outstanding thereunder will be appropriately adjusted as to the class and
the maximum number of shares subject to such Plan and the class, number of
shares and price per share subject to such outstanding Stock Awards.

EFFECT OF CERTAIN CORPORATE EVENTS

         The 1989 Plan provides that, in the event of a dissolution or
liquidation of the Company, specified types of merger or other corporate
reorganization, then at the discretion of the Board and to the extent permitted
by law, any surviving corporation shall either: assume Stock Awards outstanding
under the 1989 plan or substitute similar Stock Awards for those outstanding
under the 1989 Plan, such outstanding Stock Awards will continue in full force
and effect; or, with respect to Stock Awards held by persons then employed by or
serving as advisors, consultants or directors to the Company, then at the
discretion of the Board, the Company may either arrange to pay a cash settlement
for such Stock Award or accelerate such Stock Awards and terminate those Stock
Awards not exercised before such corporate event.

DURATION, AMENDMENT AND TERMINATION

         The Board may suspend or terminate the 1989 Plan without stockholder
approval or ratification at any time or from time to time. Unless sooner
terminated, the 1989 Plan will terminate on December 31, 2000.

         The Board may also amend the 1989 Plan at any time or from time to
time. However, no amendment will be effective unless approved by the
stockholders of the Company within twelve months or before or after its adoption
by the Board if the amendment would: (i) increase the number of shares reserved
for Stock Awards under the 1989 Plan; (ii) modify the requirements as to
eligibility for participation (to the extent such modification requires
stockholder approval in order for the Plan to satisfy Section 422(b) of the
Code, if applicable, or Rule 16b-3 ("Rule 16b-3") of the Exchange Act); or (iii)
change any other provision of the Plan in any other way if such modification
requires stockholder approval in order to satisfy the requirements of Section
422(b) of the Code or to comply with Rule 16b-3.


                                      16.
<PAGE>   22

FEDERAL INCOME TAX INFORMATION

         Incentive Stock Options. Incentive stock options under the 1989 Plan
are intended to be eligible for the favorable federal income tax treatment
accorded "incentive stock options" under the Code.

         There generally are no federal income tax consequences to the optionee
or the Company by reason of the grant or exercise of an incentive stock option.
However, the exercise of an incentive stock option may increase the optionee's
alternative minimum tax liability, if any.

         If an optionee holds stock acquired through exercise of an incentive
stock option for at least two years from the date on which the option is granted
and at least one year from the date on which the shares are transferred to the
optionee upon exercise of the option, any gain or loss on a disposition of such
stock will be capital gain or loss. Generally, if the optionee disposes of the
stock before the expiration of either of these holding periods (a "disqualifying
disposition"), at the time of disposition, the optionee will recognize taxable
ordinary income equal to the lesser of (i) the excess of the stock's fair market
value on the date of exercise over the exercise price, or (ii) the optionee's
actual gain, if any, on the purchase and sale. The optionee's additional gain or
any loss upon the disqualifying disposition will be a capital gain or loss. Any
capital gain or loss recognized by an optionee on a qualifying disposition or a
disqualifying disposition of stock acquired through exercise of an incentive
stock option will be long-term, mid-term or short-term depending on how long the
stock was held. Capital gains currently are generally subject to lower tax rates
than ordinary income. Slightly different rules may apply to optionees who
acquire stock subject to certain repurchase options or who are subject to
Section 16(b) of the Exchange Act.

         To the extent the optionee recognizes ordinary income by reason of a
disqualifying disposition, the Company will generally be entitled (subject to
the requirement of reasonableness, the provisions of Section 162(m) of the Code
and perhaps, in the future, the satisfaction of a withholding obligation) to a
corresponding business expense deduction in the tax year in which the
disqualifying disposition occurs.

         Nonstatutory Stock Options. Nonstatutory stock options granted under
the 1989 Plan generally have the following federal income tax consequences:

         There are no tax consequences to the optionee or the Company by reason
of the grant of a nonstatutory stock option. Upon exercise of a nonstatutory
stock option, the optionee normally recognizes taxable ordinary income equal to
the excess of the stock's fair market value on the date of exercise over the
option exercise price. Generally, with respect to employees, the Company is
required to withhold from regular wages or supplemental wage payments an amount
based on the ordinary income recognized. Subject to the requirement of
reasonableness, the provisions of Section 162(m) of the Code and the
satisfaction of any withholding obligation, the Company will generally be
entitled to a business expense deduction equal to the taxable ordinary income
recognized by the optionee. Upon disposition of the stock, the optionee will
recognize a capital gain or loss equal to the difference between the selling
price and the sum of the amount paid for such stock plus any amount recognized
as ordinary income upon exercise of the option. Such gain or loss will be
long-term, mid-term or short-term depending on how long the stock was held.
Slightly different rules apply to optionees who acquire stock subject to certain
repurchase options or who are subject to Section 16(b) of the Exchange Act.

         Potential Limitation on Company Deductions. Code Section 162(m) denies
a deduction to any publicly held corporation for compensation paid to certain
employees in a taxable year to the extent that compensation exceeds $1 million
for a covered employee. It is possible that compensation attributable to stock
options, when combined with all other types of compensation received by a
covered employee from the Company, may cause this limitation to be exceeded in
any particular year.

         Certain kinds of compensation, including qualified "performance-based
compensation", are disregarded for purposes of the deduction limitation. In
accordance with Treasury regulations issued under Section 162(m), compensation
attributable to stock options will qualify as performance-based compensation,
provided that (i) the option plan contains a per-employee limitation on the
number of shares for which options may be granted during a specified period,
(ii) the per employee limitation is approved by the stockholders, (iii) the
option is granted by a 


                                      17.
<PAGE>   23

compensation committee comprised solely of "outside directors," and (iv) the
exercise price of the option is not less than the fair market value of the stock
on the date of grant, or the option is granted (or becomes exercisable) only
upon the achievement (as certified by the Compensation Committee) of an
objective performance goal established by the Compensation Committee while the
outcome is substantially uncertain.

         Stock Bonuses and Restricted Stock. Stock bonuses and restricted stock
purchases granted under the 1989 Plan have the following federal income tax
consequences:

         Generally, at the time of receipt of the stock, the recipient's tax
treatment depends on whether or not he or she timely files an election under
Section 83(b) of the Code. If such an election is timely filed, the recipient
will recognize ordinary income in the amount of the difference, if any, between
the purchase price and the fair market value of the shares at the time of the
purchase. If the election is not timely filed, the recipient will recognize
ordinary income at the time of receipt only in the amount of the difference
between the purchase price and the fair market value of the shares which are not
at the time subject to the Company's repurchase option. Thereafter, whenever the
Company's repurchase option lapses with respect to a given number of shares, the
recipient will recognize ordinary income in the amount of the difference between
the purchase price and the fair market value of the shares with respect to which
the repurchase option has just lapsed.

         With respect to employees, the Company is required to withhold from
regular wages or supplemental wage payments an amount based on the ordinary
income recognized. Subject to the requirement of reasonableness, the provisions
of Section 162(m) of the Code and the satisfaction of any withholding
obligation, the Company will generally be entitled to a business expense
deduction equal to the taxable ordinary income recognized by the recipient. Upon
disposition of stock, the recipient will recognize a capital gain or loss equal
to the difference between the selling price and the sum of the amount paid for
such stock plus any amount recognized as ordinary income upon vesting of the
stock. Such gain or loss will be long-term, mid-term or short-term depending on
how long the stock was held. Slightly different rules may apply to recipients
whose stock is subject to forfeiture under Section 16(b) of the Exchange Act.

         Other Tax Consequences. The foregoing discussion is not intended to be
a complete description of the federal income tax aspects of Stock Awards granted
under the 1989 Plan. In addition, administrative and judicial interpretations of
the application of the federal income tax laws are subject to change.
Furthermore, no information is given with respect to state or local taxes that
may be applicable.

        DESCRIPTION OF THE 1994 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN

    The essential features of the Non-Employee Directors' Plan are outlined
below:

GENERAL

         Options granted under the Non-Employee Directors' Plan are not intended
to qualify as incentive stock options, as defined under Section 422 of the Code.
See "Federal Income Tax Information" below for a discussion of the tax treatment
of such options.

PURPOSE

         The purpose of the Non-Employee Directors' Plan is to retain the
services of persons now serving as Non-Employee Directors of the Company (as
defined below), to attract and retain the services of persons capable of serving
on the Board of Directors of the Company and to provide incentives for such
persons to exert maximum efforts for the success of the Company.


                                      18.
<PAGE>   24

ADMINISTRATION

         The Non-Employee Directors' Plan is administered by the Board of
Directors of the Company. The Board of Directors has the final power to construe
and interpret the Non-Employee Directors' Plan and options granted under it, and
to establish, amend and revoke rules and regulations for its administration.

         The Board of Directors is authorized to delegate administration of the
Non-Employee Directors' Plan to a committee not less than two members of the
Board. The Board of Directors does not presently contemplate delegating
administration of the Non-Employee Directors' Plan to any committee of the Board
of Directors.

ELIGIBILITY

         The Non-Employee Directors' Plan provides that options may be granted
only to Non-Employee Directors of the Company. A "Non-Employee Director" is
defined in the Non-Employee Directors' Plan as a director of the Company and its
affiliates who is not otherwise an employee of the Company or any affiliate. Six
of the Company's nine current Directors (all except Mr. Thompson and Drs.
Paulson and Roe) are eligible to participate in the Non-Employee Directors'
Plan.

         Option grants under the Non-Employee Directors' Plan are
non-discretionary. On January 1 of each year (or the first business day), each
Non-Employee Director who has been a Non-Employee Director for at least three
months shall be granted an option to purchase 5,000 shares of Common Stock of
the Company. In addition, each person who becomes a Non-Employee Director of the
Company after the adoption of the Non-Employee Directors' Plan shall, upon the
date of initial election to be a Non-Employee Director, be granted an option to
purchase 25,000 shares of Common Stock of the Company.

TERMS OF OPTIONS

         Each option under the Non-Employee Directors' Plan is subject to the
following terms and conditions.

         Option Exercise. An option granted under the Non-Employee Directors'
Plan vests daily at the rate of 25% per year, except that in a Director's first
year of service, no shares become exercisable until the date one year after the
commencement of service. Such vesting is conditioned upon continued service as a
director.

         An option granted under the Non-Employee Directors' Plan may be
exercised by giving written notice of exercise to the Company, specifying the
number of full shares of Common Stock to be purchased and tendering payment of
the purchase price to the Company.

         Exercise Price; Payment. The exercise price of options granted under
the Non-Employee Directors' Plan shall be equal to 100% of the fair market value
of the Common Stock subject to the options on the date such option is granted.
The exercise price of options granted under the Non-Employee Directors' Plan may
be paid in cash or by delivery of shares of Common Stock of the Company that
have been held for the period required to avoid a charge to the earnings of the
Company. Any shares so surrendered shall be valued at their fair market value on
the date preceding the date preceding the date of exercise.

         Transferability; Term. Under the Non-Employee Directors' Plan an option
may not be transferred by the optionee, except by will or by the laws of descent
and distribution. During the lifetime of an optionee, an option may be exercised
only by the optionee.

         No option granted under the Non-Employee Directors' Plan is exercisable
by any person after the expiration of 10 years from the date the option is
granted.

         Other Provisions. The option agreement may contain such other terms,
provisions and conditions not inconsistent with the Non-Employee Directors' Plan
as may be determined by the Board of Directors.


                                      19.
<PAGE>   25

ADJUSTMENT PROVISIONS

         If there is any change in the stock subject to the Non-Employee
Directors' Plan or subject to any option granted under the Non-Employee
Directors' Plan (through merger, consolidation, reorganization,
recapitalization, stock dividend, dividend in property other than cash, stock
split, liquidating dividend, combination of shares, exchange of shares, change
in corporate structure or otherwise), the Non-Employee Directors' Plan and
options outstanding thereunder will be appropriately adjusted as to the class
and the maximum number of shares subject to such Plan and the class, number of
shares and price per share of stock subject to such outstanding options.

         In the event of a dissolution or liquidation of the Company, a merger
or consolidation in which the Company is not the surviving corporation, a
reverse merger in which the Company is the surviving corporation but the shares
of the Company's Common Stock outstanding immediately preceding the merger were
converted by virtue of the merger into other property, or any capital
reorganization in which more than 50% of the shares of the Company entitled to
vote are exchanged, the vesting of any outstanding options under the
Non-Employee Directors' Plan shall accelerate and such options shall terminate
if unexercised prior to the occurrence of the event.

DURATION, AMENDMENT AND TERMINATION

         The Board of Directors' may amend, suspend or terminate the
Non-Employee Directors' Plan at any time or from time to time; provided,
however, that the Board of Directors may not amend the Non-Employee Directors'
Plan with respect to the amount, price or timing of grants more often than once
every six months. No amendment will be effective unless approved by the
stockholders of the Company within 12 months before or after its adoption by the
Board if the amendment would: (i) increase the number of shares reserved for
options under the Non-Employee Directors' Plan; (ii) modify the requirements as
to eligibility for participation in the Non-Employee Directors' Plan (to the
extent such modification requires stockholder approval in order for the
Non-Employee Directors' Plan to comply with the requirements of Rule 16b-3); or
(iii) modify the Non-Employee Directors' Plan in any other way if such
modification requires stockholder approval in order for the Non-Employee
Directors' Plan to meet the requirements of Rule 16b-3. Unless sooner
terminated, the Non-Employee Directors' Plan will terminate in March 2004.

FEDERAL INCOME TAX INFORMATION

         The following is only a summary of the effect of federal income
taxation upon the optionee and the Company with respect to the grant and
exercise of options under the Non-Employee Directors' Plan, does not purport to
be complete and does not discuss the income tax laws of any state or foreign
country in which an optionee may reside.

         Options granted under the Non-Employee Directors' Plan generally have
the following federal income tax consequences:

         There are no tax consequences to the optionee or the Company by reason
of the grant of an option under the Non-Employee Directors' Plan. Upon exercise
of such option, the optionee normally will recognize taxable ordinary income
equal to the excess of the stock's fair market value on the date of exercise
over the option exercise price. Because the optionee is a director of the
Company, under existing laws, the date of taxation (and the date of measurement
of taxable ordinary income) may in some instances be deferred unless the
optionee files an election under Section 83(b) of the Code. The filing of a
Section 83(b) election with respect to the exercise of an option may affect the
time of taxation and the amount of income recognized at each such time. Upon
disposition of the stock acquired upon exercise, the optionee will recognize a
capital gain or loss equal to the difference between the selling price and the
sum of the amount paid for such stock plus any amount recognized as ordinary
income upon exercise of the option. Such gain or loss will be long-term,
mid-term or short-term depending on the length of time the stock was held.
Slightly different rules apply to optionees who are subject to Section 16(b) of
the 1934 Act.


                                      20.
<PAGE>   26

GRANTS

         Only Non-Employee Directors of the Company are eligible to receive
options under the Non-Employee Directors' Plan. All Non-Employee Directors as a
group received options to purchase an aggregate of 25,000 shares of Common Stock
in fiscal year 1997 at a dollar value of $85,950 (based on the exercise price of
each option multiplied by the number of shares underlying such options). Such
grants are not necessarily indicative of the number of options that will be
granted in the future.

                                   PROPOSAL 6

                RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

         The Board of Directors has selected Ernst & Young LLP as the Company's
independent auditors for the fiscal year ending December 31, 1998, and has
further directed that management submit the selection of independent auditors
for ratification by the stockholders at the Annual Meeting. Ernst & Young LLP
has audited the Company's financial statements since the Company's inception in
1987. Representatives of Ernst & Young LLP are expected to be present at the
Annual Meeting, will have an opportunity to make a statement if they desire to
do so and will be available to respond to appropriate questions.

         Stockholder ratification of the selection of Ernst & Young LLP as the
Company's independent auditors is not required by the Company's By-laws or
otherwise. The Board of Directors has elected to seek such ratification as a
matter of good corporate practice. Should the stockholders fail to ratify the
selection of Ernst & Young LLP as independent auditors, the Board of Directors
will reconsider whether or not to retain that firm for the fiscal year ending
December 31, 1998. Even if the selection is ratified, the Board in its
discretion may direct the appointment of a different independent accounting firm
at any time during the year if the Board determines such a change would be in
the best interest of the Company and its stockholders.

         The affirmative vote of a majority of the shares present in person or
represented by proxy and entitled to vote on the proposal at the meeting will be
required to ratify the selection of Ernst & Young LLP.

                 MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND
                         A VOTE IN FAVOR OF PROPOSAL 6.


                                      21.
<PAGE>   27

                              SECURITY OWNERSHIP OF
                    CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table sets forth certain information regarding the
ownership of Common Stock of the Company as of March 13, 1998 by (i) each
director and nominee; (ii) each Named Executive Officer (as defined below);
(iii) all executive officers and directors as a group; and (iv) all those known
by the Company to be beneficial owners of more than five percent of its Common
Stock:

<TABLE>
<CAPTION>
                                                                         BENEFICIAL OWNERSHIP(1)
                                                                      ----------------------------
                                                                        NUMBER OF       PERCENT OF
      BENEFICIAL OWNER                                                   SHARES           TOTAL
      ----------------                                                -----------       ----------
<S>                                                                   <C>               <C>  
 International Biotechnology Trust plc
   Five Arrows House, St. Swithin's Lane,
   London, England...........................................            3,275,949        9.97%
 State of Wisconsin Investment Board
   121 East Wilson Street
   Madison, WI 53702.........................................            2,425,000        7.38%
 G.D. Searle & Co. (2)
   5200 Old Orchard Road
   Skokie, IL 60077..........................................            2,222,222        6.76%
 Sandoz Holding Ltd.
   CH-4002 Basel Switzerland.................................            2,166,700        6.59%
 Equitable Life Assurance Company
   City Place House
   Basinghall Street
   London, England C2V SDK...................................            1,714,285        5.22%
 Howard E. Greene, Jr. (3)(6)................................              791,761        2.41%
 James C. Paulson (4)(6).....................................              438,631        1.33%
 Virgil Thompson (6).........................................              436,296        1.32%
 Robert L. Roe (6)...........................................              317,959        *
 David L. Anderson (5)(6)....................................              236,434        *
 Robert W. Chesnut (6).......................................              205,212        *
 Deborah Schueren (6)........................................               83,274        *
 Jennifer Lorenzen (6).......................................               42,560        *
 William T. Comer (6)........................................               40,509        *
 David L. Mahoney............................................               30,249        *
 Nicole Vitullo (6)..........................................                1,807        *
 Nancy D. Rasmussen..........................................                    0        *
 Karin Eastham...............................................                    0        *
 All executive officers and directors
   as a group (12 persons)(7)................................            2,624,692        7.69%
</TABLE>

- ------------

*    Less than one percent.

(1)  This table is based upon information supplied by officers, directors and
     principal stockholders and on any Schedules 13D or 13G filed with the
     Securities and Exchange Commission (the "SEC"). Unless otherwise indicated
     in the footnotes to this table and subject to community property laws where
     applicable, each stockholder named in this table has sole voting and
     investment power with respect to the shares indicated as beneficially
     owned. Applicable percentage ownership is based on 32,859,887 shares of
     Common Stock outstanding on March 13, 1998, adjusted as required by rules
     promulgated by the SEC.


                                      22.
<PAGE>   28
 (2) Does not include 659,898 shares of Series B Preferred Stock issued to
     Searle in February 1998 pursuant to a collaboration between Epimmune Inc.,
     a subsidiary of the Company ("Epimmune"), and Searle. Searle has the right
     to convert the Series B Preferred Stock into Cytel Common Stock after three
     years, at a conversion rate of .788 shares of Common Stock for each share
     of Series B Preferred Stock (for an aggregate of 519,999 shares of Common
     Stock) or to convert to Epimmune Common Stock at any time. In addition,
     Searle has the option to deliver shares of the Series B Preferred Stock in
     lieu of up to 50% of certain milestone payments to Epimmune. See "Certain
     Transactions."

(3)  Includes 453,604 shares held in trust for the benefit of Mr. Greene's
     family, 16,000 shares held in trust for the benefit of Mr. Greene's
     children and 314,632 shares held individually by Mr. Greene. Mr. Greene
     is a trustee of both trusts. Mr. Greene acting as trustee has voting and
     investment power with respect to such shares and may be deemed to be the
     beneficial owner of such shares. In addition, Mr. Greene is a director of
     International Biotechnology Trust plc and disclaims beneficial ownership
     of shares held by such entity.

(4)  Includes 31,500 shares held in trust for the benefit of Dr. Paulson's three
     minor children.

(5)  Includes 10,000 shares held by Anvest, L.P. of which Mr. Anderson is the
     general partner. Also includes 137,461 shares held of record by Sutter
     Hill, over which Mr. Anderson exercises voting and investing power as a
     managing director of Sutter Hill Ventures LLC, the general partner of
     Sutter Hill. Mr. Anderson disclaims beneficial ownership of shares held by
     Anvest, L.P. and Sutter Hill except to his proportionate partnership
     interest therein.

(6)  Includes shares which certain executive officers and directors of the
     Company have the right to acquire within 60 days after the date of this
     table pursuant to outstanding options, as follows: Howard E. Greene, 7,525
     shares; James C. Paulson, 285,618 shares; Virgil Thompson, 325,844 shares;
     Robert L. Roe, 308,713 shares; David L. Anderson, 7,525 shares; Robert W.
     Chesnut, 156,292 shares; Deborah Schueren, 81,334 shares; Jennifer
     Lorenzen, 42,560 shares; William T. Comer, 34,109 shares; David L. Mahoney,
     10,249 shares; Nicole Vitullo, 1,807 shares; and all executive officers and
     directors as a group, 1,261,576 shares.

(7)  Includes shares described in notes (3) through (6) above.

                             EXECUTIVE COMPENSATION

COMPENSATION OF DIRECTORS

         Directors of the Company who are not employees of the Company are paid
$2,000 per meeting attended in person and $500 per meeting attended by phone as
compensation for their service on the Board of Directors. Directors are not
compensated for actions taken by written consent. The members of the Board of
Directors are eligible for reimbursement of expenses incurred in connection with
their service on the Board. Under the Directors' Deferred Compensation Plan,
participating directors may elect on an annual basis, to defer all of their cash
compensation in a deferred stock account pursuant to which the deferred fees are
credited in the form of shares of the Company's Common Stock, based on the
market price of the stock at the time the deferred fees are earned. The Company
will continue to credit shares of the Company's Common Stock to the
participants' deferred stock accounts on a quarterly basis. When a participant
ceases serving as a director, the participant shall be entitled to receive the
value of his or her account either in a single lump-sum payment or in equal
annual installments, as determined by the Company in its sole discretion. No
participant entitled to receive a payment of benefits shall receive payment in
the form of the Company's Common Stock.

         Under the Non-Employee Directors' Plan, on January 1 of each year, each
director who is not an employee of the Company and has served on the Board for
at least three months, is granted an option to acquire 5,000 shares of the
Company's Common Stock. In addition, each new Non-Employee Director will be
granted an option to acquire 25,000 shares of the Company's Common Stock upon
initial election to the Board of Directors. The exercise price of all such stock
options granted is equivalent to the fair market value on the date of each
grant.

COMPENSATION OF EXECUTIVE OFFICERS

         The following table shows for the fiscal years ended December 31, 1997,
1996 and 1995, compensation awarded or paid to, or earned by the Company's Chief
Executive Officer, its other four most highly compensated 


                                      23.
<PAGE>   29

executive officers at December 31, 1997 and two former executive officers who
departed from the Company during the last fiscal year (collectively, the "Named
Executive Officers"). During the last three fiscal years, none of the executive
officers received any restricted stock awards or long-term incentive payouts.
The column marked Securities Underlying Options includes options issued on
December 15, 1994 under the Company's option exchange program. For each
employee, the receipt of the replacement grant was subject to the employee's
consent to the cancellation of the original grant, thereby forfeiting all prior
vesting of the original grant.

                           SUMMARY COMPENSATION TABLE
<TABLE>
<CAPTION>
                                                                                               LONG-TERM
                                                                                             COMPENSATION
                                                                                                AWARDS
                                              ANNUAL COMPENSATION                             SECURITIES
                                             ---------------------                            UNDERLYING         ALL OTHER
    NAME AND PRINCIPAL                                     SALARY            BONUS              OPTIONS        COMPENSATION
         POSITION                            YEAR            ($)              ($)                 (#)             ($)(1)
- ------------------------------------         ----         --------         --------         ---------------    ------------
<S>                                          <C>          <C>              <C>                <C>              <C>  
Mr. Virgil Thompson                          1997          315,000                0             200,000            5,426
  President and Chief                        1996          300,000           78,580(2)          500,000            4,950
  Executive Officer
Dr. Robert L. Roe                            1997          286,000                0             180,000            4,874
  Executive Vice President                   1996          205,354           23,000(3)          400,000            3,525
  and Chief Operating Officer
Dr. James C. Paulson                         1997          257,578                0                   0            1,674
  Vice President and                         1996          216,324           28,988              80,000            1,333
  General Manager, Glytec(TM)                1995          206,023           41,205              60,000              890
Ms. Deborah Schueren (4)                     1997          133,572                0             120,000(5)           295
  Vice President, Cytel and
  President, Epimmune
Jennifer Lorenzen (6)                        1997          134,055                0              90,000              691
  Vice President, Business
   Development
Dr. Robert W. Chesnut (7)                    1997          147,684                0                   0            1,553
  Former Vice President,                     1996          165,375           22,160              60,000            1,619
   Immune Stimulation Program                1995          157,500           31,500              60,000              680
Ms. Karin Eastham (8)                        1997           86,864                0                   0              368
  Former Vice President,                     1996          177,197           23,744              60,000             1058
  Finance and Administration                 1995          168,759           33,752              60,000              729
  And Chief Financial Officer
</TABLE>

- ------------

(1)  Consists of life insurance premiums paid by the Company.

(2)  Represents relocation payments made by the Company to Mr. Thompson.

(3)  Represents reimbursement of Dr. Roe's relocation expenses which were paid
     by the Company to Dr. Roe's previous employer.

(4)  Ms. Schueren was appointed Vice President, Finance and Chief Financial
     Officer in March 1997. Ms Schueren resigned as Vice President, Finance and
     Chief Financial Officer effective October 1997, at which time she was
     appointed Vice President of the Company and President of Epimmune.

(5)  Does not include certain options to purchase shares of Epimmune Common
     Stock granted to Ms. Schueren. See "Employment Agreements."


                                      24.
<PAGE>   30

     appointed Vice President of the Company and President of Epimmune Inc., a
     subsidiary of the Company ("Epimmune").

(6)  Ms. Lorenzen was Vice President, Development Program Management of the
     Company from April 1997 to February 1998, at which time she was appointed
     Vice President, Business Development of the Company.

(7)  Dr. Chesnut resigned from the Company effective October 1997, at which time
     he was appointed Executive Vice President of Research and Development of
     Epimmune.

(8)  Ms. Eastham resigned from the Company effective April 1997.

                        STOCK OPTION GRANTS AND EXERCISES

         The Company grants options to its executive officers under the 1989
Plan. As of March 13, 1998, options to purchase a total of 4,614,002 shares had
been granted and were outstanding under the 1989 Plan, and options to purchase
185,144 shares remained available for grant thereunder. Material terms of
options granted under the 1989 Plan are described generally in footnotes 1 and 4
below.

         The following tables show for the fiscal year ended December 31, 1997,
certain information regarding options granted to, exercised by, and held at year
end by the Named Executive Officers:

                       OPTIONS GRANTED IN LAST FISCAL YEAR

<TABLE>
<CAPTION>
                                                         INDIVIDUAL GRANTS                         POTENTIAL REALIZABLE
                                        ------------------------------------------------------       VALUE AT ASSUMED   
                                         NUMBER OF       %TOTAL                                         ANNUAL RATES    
                                        SECURITIES       OPTIONS                                       OF STOCK PRICE   
                                        UNDERLYING     GRANTED TO                                     APPRECIATION FOR  
                                          OPTIONS       EMPLOYEES     EXERCISE OR                       OPTION TERM(3)  
                                          GRANTED       IN FISCAL     BASE PRICE     EXPIRATION   -----------------------
          NAME                              (1)          YEAR(2)        ($/SH)          DATE          5%($)        10%($)
          ----                          ----------     -----------    -----------   -----------   -----------   ---------
<S>                                     <C>            <C>             <C>           <C> <C>      <C>          <C>    
Mr. Virgil Thompson ............         200,000(4)      21.4            4.00          1/1/07       320,028      983,457
Dr. Robert L. Roe ..............         180,000(4)      19.2            4.00          1/1/07            --           --
Dr. James C. Paulson ...........              --           --              --              --       288,025      885,112
Ms. Deborah Schueren ...........         120,000         12.8           2.375         3/20/07       179,235      454,217
Ms. Jennifer Lorenzen ..........          90,000          9.6           1.375         4/29/07        77,826      197,226
Dr. Robert W. Chesnut ..........              --           --              --              --            --           --
Ms. Karin Eastham ..............              --           --              --              --            --           --
</TABLE>

- ------------

(1)  Options granted prior to 1996 generally vested 20% at the end of the first
     year of the optionee's employment and thereafter daily at the rate of 20%
     per year during such period of employment. Options granted after November
     1996 generally vest 25% at the end of the first year of the optionee's
     employment and thereafter daily at the rate of 25% per year during such
     period of employment. Upon certain corporate events resulting in a change
     of control, at the discretion of the Company's Board of Directors, (i) the
     acquiring company will assume the options or substitute similar options,
     (ii) the options will continue in full force and effect, or (iii) the
     Company will pay a cash settlement for or accelerate such options. The
     Board of Directors has agreed at the request of the Wisconsin Board not to
     reprice any options without prior stockholder approval until June 2000. As
     set forth in Proposal 3, the Company is seeking stockholder approval of an
     option exchange program at the Annual Meeting. The Wisconsin Board has
     advised the Company that it intends to vote in favor of Proposal 3. The
     Board of Directors has further agreed with The Wisconsin Board not to
     reprice any options additional to those covered by Proposal 3 until
     December 1998.
     


(2)  Based on 936,518 options granted in 1997, including grants to executive
     officers.


                                      25.
<PAGE>   31

(3) The potential realizable value is calculated based on the terms of the
    option at its time of grant (10 years in the case of all options). It is
    calculated by assuming that the stock price on the date of grant appreciates
    at the indicated annual rate, compounded annually for the entire term of the
    option and that the option is exercised and sold on the last day of its term
    for the appreciated stock price. These amounts represent certain assumed
    rates of appreciation, in accordance with rules of the SEC, and do not
    reflect the Company's estimate or projection of future stock price
    performance. Actual gains, if any, are dependent on the actual future
    performance of the Company's Common Stock, and no gain to the optionee is
    possible unless the stock price increases over the option term, which will
    benefit all stockholders.

(4) These options vest daily at the rate of 33% per year during the period of
    the optionee's employment. The vesting of the options could have accelerated
    over a two-year period based upon achievement of certain objectives for
    1997, with two-thirds of the options vesting in the first year and the
    remaining one-third of the options vesting in the second year. Such
    objectives were not achieved.

              AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND
                         FISCAL YEAR-END OPTION VALUES

<TABLE>
<CAPTION>
                                                                NUMBER OF SECURITIES UNDERLYING       VALUE OF UNEXERCISED
                                                               UNEXERCISED OPTIONS AT OPTIONS AT    IN-THE-MONEY OPTIONS AT
                                                                            FY-END(#)                      FY-END($)(1)
                              SHARES            VALUE          ---------------------------------    ------------------------
                             ACQUIRED          REALIZED                   EXERCISABLE/                      EXERCISABLE/
          NAME            ON EXERCISE(#)         ($)                    UNEXERCISABLE                     UNEXERCISABLE
          ----            --------------       --------                 --------------                     -------------
<S>                       <C>                  <C>             <C>                                  <C>
Mr. Virgil Thompson             --                --                    199,658/500,342                        --/--
Dr. Robert L. Roe               --                --                    191,507/388,493                        --/--
Dr. James C. Paulson            --                --                    252,695/165,162                      $20,523/--
Ms. Deborah Schueren            --                --                    63,663/133,127                         --/--
Ms. Jennifer Lorenzen           --                --                    30,082/109,918                     $1,894/$9,356
Dr. Robert W. Chesnut           --                --                      156,292/--                         $5,308/--
Ms. Karin Eastham               --                --                         --/--                             --/--
</TABLE>

- ------------

(1)  Fair market value of the Company's Common Stock at December 31, 1997 ($1.50
     per share) minus the exercise price of the options.

                              EMPLOYMENT AGREEMENTS

         In March 1990, the Company entered into an employment agreement with
Dr. Paulson. The agreement may be terminated by either the Company or Dr.
Paulson. The terms of the employment agreement are consistent with the Company's
executive compensation policies.

         In January 1996, the Company entered into an employment agreement with
Mr. Thompson. The agreement may be terminated by either the Company or Mr.
Thompson. The terms of the employment agreement are consistent with the
Company's executive compensation policies.

         In January 1996, the Company entered into an employment agreement with
Dr. Roe. The agreement may be terminated by either the Company or Dr. Roe. The
terms of the employment agreement are consistent with the Company's executive
compensation policies.

         In October 1997, the Company and Epimmune entered into an employment
agreement with Ms. Schueren. The agreement guaranteed Ms. Schueren a base salary
of $185,000 and a cash bonus of up to $50,000 at the discretion of the Board, if
certain objectives are met. In addition, pursuant to the agreement, Ms. Schueren
was granted an incentive stock option to purchase 385,000 shares of Epimmune
Common Stock at the fair market value as determined by the board of directors of
Epimmune. Shares subject to such option vest equally over 48 months, provided
that said option will be subject to acceleration with respect to up to two years
of vesting upon achievement of certain objectives. The option issued to Ms.
Schueren represents approximately 4% of the outstanding Epimmune Common Stock on
an as-converted, fully-diluted basis, assuming exercise of all options
outstanding and


                                      26.
<PAGE>   32
available for issuance under Epimmune's stock option plan. The agreement may be
terminated by either the Company or Ms. Schueren.

         In February 1998, the Company entered severance benefits agreements
covering the following officers of the Company: Mr. Thompson, Dr. Roe, Dr.
Paulson and Ms. Lorenzen (collectively, the Officers and individually, the
"Officer"). Under the agreements, in the event that an Officer is either
terminated without cause or within one year of a change of control of the
Company such Officer shall receive a lump-sum payment equal to six months of
such Officer's annual base salary. If such Officer is terminated other than for
cause, all unvested stock options held by such Officers shall immediately
accelerate by six months. If such Officer is terminated following a change of
control, 50% of all unvested stock options held by such Officer shall
immediately vest and become exercisable. Ms. Schueren's employment agreement
provides for similar severance benefits except in the event of termination
following a change in control, all unvested Epimmune stock options held by Ms.
Schueren shall immediately vest and become exercisable. In addition, generally,
if Ms. Schueren is terminated without cause or if Ms. Schueren terminates her
employment under certain conditions, all unvested stock options held by Ms.
Schueren shall accelerate by six months. 


                                      27.
<PAGE>   33

                        COMPENSATION COMMITTEE REPORT(1)

         The Compensation Committee of the Board of Directors (the "Committee")
consists of Mr. Howard E. Greene, Jr., Mr. David L. Anderson and Mr. David L.
Mahoney. The Committee is responsible for setting and administering the
Company's policies governing annual executive salaries, bonuses (if any) and
stock ownership programs. The Committee evaluates the performance of management
and determines the compensation of the Chief Executive Officer ("CEO") and the
other executive officers of Cytel based upon the accomplishment of defined
objectives in the Company's research and product development programs and
achievement of financial targets. The full Board of Directors reviews the
Committee's recommendations regarding the compensation of the CEO and the other
executive officers.

EXECUTIVE OFFICER COMPENSATION PROGRAM

         The Company's executive officer compensation program consists of base
salary and long-term compensation in the form of stock options. The Company's
executive officer compensation program is designed to achieve the following
objectives:

         -        Attract, retain and motivate quality executives who possess
                  the necessary leadership and management skills.

         -        Provide an incentive to advance the research and development
                  of the Company's therapeutic products.

         -        Emphasize stock-based compensation to provide longer-term
                  motivation by aligning the executives' interests with those of
                  the Company and its stockholders.

         Compensation is based on the level of job responsibility and the level
of the individual's performance as well as the Company's performance. The
Committee endeavors to set executive compensation within a range which the
Committee believes is comparable to the average range of compensation set by
companies of comparable size in the biotechnology industry. The group of
comparable companies is not necessarily the same as the companies reflected in
the market indices included in the performance graph on page 30 of this Proxy
Statement.

         The Committee believes that the Company's executive compensation
program reflects the principles described above and provides executives strong
incentives to maximize Company performance and enhance stockholder value. The
Committee believes that a stock option program to reward performance is an
appropriate method of executive compensation, with relatively modest increases
in base compensation.

BASE SALARY

         Base salary levels for each of the Company's executive officers are
reviewed annually. The Company applies various subjective criteria, including
performance of the individual and the Company and relative responsibility and
experience, to determine appropriate base salaries. In evaluating Company
performance, the Committee considers the meeting of certain product milestones,
achieving certain corporate objectives (related to financings and
collaborations) and organizational effectiveness. In addition, the Company
compares its executives' base salaries to management salaries at companies in
the biotechnology industry, comparable geographic areas and at similar stages of
growth and considers industry surveys regarding executive compensation. The
Committee uses 

- --------

(1)  The material in this report is not "soliciting material," is not deemed
     filed with the SEC, and is not to be incorporated by reference into any
     filing of the Company under the Securities Act of 1933, as amended (the
     "1933 Act") or the 1934 Act, whether made before or after the date hereof
     and irrespective of any general incorporation language contained in such
     filing.


                                      28.

<PAGE>   34

these criteria as a frame of reference for annual salary adjustments although
other factors are considered, as appropriate, and no specific weights are
ascribed to the factors considered by the Committee.

LONG-TERM INCENTIVE COMPENSATION

         The Company's long-term incentive program includes stock options and
other awards granted under the 1989 Plan, other stock options and the Company's
Employee Stock Purchase Plan. Stock options are an important part of the
Company's performance-based compensation. Option grants include vesting periods
(generally over four years) to encourage key employees to continue in the employ
of the Company. In 1998, the Company implemented a performance management system
(the "Performance Management System") for members of certain employee teams
organized under the Performance Management System. Under the Performance
Management System, options are subject to acceleration of vesting upon the
achievement of certain performance-based objectives by such teams. Prior to
December 1996, the time-based vesting period of option grants was five years,
but the Board of Directors changed such vesting schedule to four years to
facilitate the recruitment and retention of key employees. Through option
grants, executives receive significant equity incentives to build long-term
stockholder value. Grants are generally made at 100% of fair market value on the
date of grant. The 1989 Plan has been amended to limit the number of shares that
can be granted to any person to 500,000 shares in any calendar year to ensure
that any income recognized in connection with the exercise of options under the
1989 Plan would qualify as "performance-based compensation" under Section 162(m)
of the Code.

         The Board of Directors has agreed at the request of the Wisconsin Board
not to reprice any options without prior stockholder approval until December
1998. As set forth in Proposal 3, the Company is seeking stockholder approval of
an option exchange program at the Annual Meeting. The Wisconsin Board has
advised the Company that it intends to vote in favor of Proposal 3.

         The Committee believes that providing management a substantial economic
interest in the long-term appreciation of the Company's Common Stock further
aligns the interests of stockholders and management. The size of option grants
to an individual is primarily determined by such individual's position within
management of the Company, as well as competitive practices at biotechnology
companies of comparable size. The Committee also considered the size of grants
to individuals in previous years and internal relativity.

         Section 162(m) of the Code limits the Company to a deduction for
federal income tax purposes of no more than $1 million paid to certain Named
Executive Officers in a taxable year. Compensation above $1 million may be
deducted if it is "performance-based compensation" within the meaning of the
Code. The statute containing this law and the applicable Treasury regulations
offer a number of transitional exceptions to this deduction limitation for
preexisting compensation plans, arrangements and binding contracts. As a result,
the Compensation Committee believes that at the present time it is unlikely that
the compensation paid to any Named Executive Officer in a taxable year which is
subject to the deduction limit will exceed $1 million. Therefore, the
Compensation Committee has not yet established a policy for determining which
forms of incentive compensation awarded to Named Executive Officers will be
designed to qualify as performance-based compensation.

         In each of fiscal 1997, 1996 and 1995 a pool of grants to a defined
management group was approved. Individual awards were based on an evaluation of
previous awards, vested status and retention goals.

CEO COMPENSATION

         The total compensation program for Mr. Virgil Thompson, Chief Executive
Officer of the Company, is largely based on the same components as for other
senior executives. Each year the Committee reviews the Chief Executive Officer's
existing compensation arrangement, the individual performance for the calendar
year under review, as well as the Company's performance relative to its peers.

         In December 1996, the Committee reviewed the achievement of objectives
for 1996, and, based on continued progress in the Company's scientific programs
and Mr. Thompson's significant efforts in planning and implementing strategic
and financial initiatives, the Committee approved a base salary for Mr. Thompson
of $315,000 for 1997, an increase of 5% over Mr. Thompson's 1996 base salary. In
addition, based on such factors, 


                                      29.
<PAGE>   35

the Board of Directors also granted Mr. Thompson an option to purchase 200,000
shares of the Company's Common Stock under the 1989 Plan at an exercise price of
$4.00 per share. The fair market value on the date of grant of such option was
$3.44 per share.

         In February 1998, the Committee reviewed the achievement of objectives
for 1997, and, based on the Company's performance in 1997 and Mr. Thompson's
significant efforts in planning and implementing strategic and financial
initiatives, the Committee approved a base salary for Mr. Thompson of $326,000
for 1998, an increase of 3.5% over Mr. Thompson's 1997 base salary. In addition,
based on such factors, the Board of Directors also granted Mr. Thompson an
option to purchase 200,000 shares of the Company's Common Stock under the 1989
Plan at an exercise price of $1.594, the fair market value on the date of grant.

         From the members of the Compensation Committee of Cytel:

                  Howard E. Greene, Jr.

                  David L. Anderson

                  David L. Mahoney


           COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         Mr. Greene, a member of the Compensation Committee, is Chairman of the
Board of the Company.


                                      30.
<PAGE>   36
                     PERFORMANCE MEASUREMENT COMPARISON(1)

         The following chart shows total shareholder return of the Nasdaq CRSP
Total Return Index ("Nasdaq Broad Index") for the Nasdaq Stock Market (US
Companies) and the Nasdaq CRSP Pharmaceutical Index ("Nasdaq Pharmaceutical
Index")(2) and for the Company as of the end of each year since December 31,
1992.

             COMPARISON OF TOTAL CUMULATIVE RETURN ON INVESTMENT(3)

<TABLE>
<CAPTION>
                                       12/92     12/93      12/94      12/95       12/96      12/97
                                       -----     -----      -----      -----       -----      -----
<S>                                    <C>       <C>        <C>        <C>         <C>        <C>
Cytel Corporation ..................    100        51         35         65          37         16
Nasdaq Stock Market - US ...........    100        51         67        123         123        127
Nasdaq Pharmaceutical ..............    100       115        134        159         195        240
</TABLE>

(1) This Section is not "soliciting material," is not deemed filed with the SEC,
    and is not to be incorporated by reference into any filing of the Company
    under the 1933 Act or the 1934 Act, whether made before or after the date
    hereof and irrespective of any general incorporation language in such
    filing.

(2) The Nasdaq Pharmaceutical Index is made up of all companies with the
    Standard Industrial Classification (SIC) code 283 (category description
    "Drugs"). Information regarding the companies comprising this index is
    available upon written request to Secretary, Cytel Corporation, 3525 John
    Hopkins Court, San Diego, California 92121.

(3) The total return on investment (including investment of dividends) assumes
    $100 invested on December 31, 1992 in each of Cytel's Common Stock (at the
    then-market price of $9.38 per share), the Nasdaq CRSP Total Return Index
    for the Nasdaq Stock (U.S. Companies) Index and the NASDAQ CRSP
    Pharmaceutical Index.


                                      31.
<PAGE>   37

                              CERTAIN TRANSACTIONS

         The Company's By-laws provide that the Company will indemnify its
directors and executive officers and may indemnify its other officers, employees
and other agents to the fullest extent permitted by Delaware law. The Company is
also empowered under its By-laws to enter into indemnification contracts with
its directors and officers and to purchase insurance on behalf of any person
whom it is required or permitted to indemnify. Pursuant to this provision, the
Company has entered into indemnity agreements with each of its directors and
officers.

         In addition, the Company's Certificate of Incorporation provides that
to the fullest extent permitted by Delaware law, the Company's directors will
not be liable for monetary damages for breach of the directors' fiduciary duty
of care to the Company and its stockholders. This provision in the Certificate
of Incorporation does not eliminate the duty of care, and in appropriate
circumstances equitable remedies such as an injunction or other forms of
non-monetary relief would remain available under Delaware law. Each director
will continue to be subject to liability for breach of the director's duty of
loyalty to the Company, for acts or omissions not in good faith or involving
intentional misconduct or knowing violations of law, for acts or omissions that
the director believes to be contrary to the best interests of the Company or its
stockholders, for any transaction from which the director derived an improper
personal benefit, for acts or omissions involving a reckless disregard for the
director's duty to the Company or its stockholders when the director was aware
or should have been aware of a risk of serious injury to the Company or its
stockholders, for acts or omissions that constitute an unexcused pattern of
inattention that amounts to an abdication of the director's duty to the Company
or its stockholders, for improper transactions between the director and the
Company, and for improper distributions to stockholders and loans to directors
and officers. This provision also does not affect a director's responsibilities
under any other laws, such as the federal securities laws or state or federal
environmental laws.

         In December 1997, the Company completed a private placement of
4,777,139 shares of Common Stock to 11 accredited investors at a purchase price
of $1.75 per share, resulting in gross proceeds to the Company of $8,359,993.
In connection with such private placement, the Greene Family Trust purchased
142,857 shares of Common Stock. Howard E. Greene, Jr., Chairman of the Board of
Directors of the Company is the trustee of such trust. International
Biotechnology Trust plc ("IBT") purchased 1,142,857 Shares of Common Stock.
IBT is a publicly traded fund managed by Rothschild. Nicole Vitullo, a
director of the Company, is Senior Vice President of Rothschild.

         In September 1997, the Company entered into a letter of intent with
Searle regarding a proposed collaboration. In connection therewith, the Company
issued 2,222,222 shares of Common Stock to Searle at a purchase price of $2.25
per share for an aggregate of $5,000,000. Pursuant to a definitive agreement
between Epimmune and Searle entered into in February 1998, Searle made an
investment of $10 million in Epimmune, of which $6.1 million was in Epimmune
Convertible Preferred Stock and $3.9 million in Cytel Series B Preferred Stock.
Cytel simultaneously purchased $3.9 million of Epimmune's Convertible Preferred
Stock. Searle has the right to convert the Cytel Series B Preferred Stock into
Cytel Common Stock after three years or to convert to Epimmune Common Stock at
any time. In addition to the $15 million investment made to date, Searle will
make milestone payments to Epimmune upon achievement of certain preclinical and
clinical milestones. Searle has the option to deliver shares of the Cytel Series
B Preferred Stock in lieu of up to 50% of certain milestone payments. Searle
will also pay royalties to Epimmune on product sales. In addition, Searle has
rights of first refusal with respect to newly-issued securities of the Company,
enabling Searle to maintain its percentage ownership in the Company.

         The Company has entered into certain additional transactions with its
directors and officers, as described under the captions "Executive Compensation"
and "Employment Agreements."

                COMPLIANCE WITH SECTION 16(a) OF THE EXCHANGE ACT

         Section 16(a) of the 1934 Act requires the Company's officers and
directors, and persons who own more than 10% of a registered class of the
Company's equity securities, to file reports of ownership and changes in
ownership with the SEC and Nasdaq National Market System. Officers, directors
and greater than 10% beneficial owners are required by SEC regulations to
furnish the Company with copies of all Section 16(a) forms they file.

         Based solely on review of the copies of such forms furnished to the
Company or written representations from certain reporting persons that no Forms
5 were required, the Company believes that, during the 1997 calendar year, all
Section 16(a) filing requirements applicable to its officers, directors and
greater than 10% beneficial owners were complied with.


                                      32.
<PAGE>   38
                                  OTHER MATTERS

         The Board of Directors know of no other business to be presented at the
meeting, but if other matters do properly come before the meeting, it is
intended that the persons named in the proxy will vote in respect thereof in
accordance with their best judgment.

                                      By Order of the Board of Directors


                                      /s/ EDWARD C. HALL   
                                      Edward C. Hall
                                      Vice President, Finance, Chief Financial 
                                        Officer and Secretary

May 4, 1998

A COPY OF THE COMPANY'S ANNUAL REPORT TO THE SECURITIES AND EXCHANGE COMMISSION
ON FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER 31, 1997 IS AVAILABLE WITHOUT
CHARGE UPON WRITTEN REQUEST TO CORPORATE SECRETARY, CYTEL CORPORATION, 3525 JOHN
HOPKINS COURT, SAN DIEGO, CA 92121.


                                      33.
<PAGE>   39
                                CYTEL CORPORATION
                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON JUNE 12, 1998


        The undersigned hereby appoints VIRGIL THOMPSON and ROBERT L. ROE, and
each of them, as attorneys and proxies of the undersigned, with full power of
substitution, to vote all of the shares of stock of Cytel Corporation which the
undersigned may be entitled to vote at the Annual Meeting of Stockholders of
Cytel Corporation to be held at 3525 John Hopkins Court, San Diego, California,
on Friday, June 12, 1998 at 1:30 p.m. (local time), and at any and all
postponements, continuations and adjournments thereof, with all powers that the
undersigned would possess if personally present, upon and in respect of the
following matters and in accordance with the following instructions, with
discretionary authority as to any and all other matters that may properly come
before the meeting.

        UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR
ALL NOMINEES LISTED IN PROPOSAL 1 AND FOR PROPOSALS 2, 3, 4, 5 AND 6 AS MORE
SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT. IF SPECIFIC INSTRUCTIONS ARE
INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH.

MANAGEMENT RECOMMENDS A VOTE FOR THE NOMINEE FOR DIRECTOR LISTED BELOW.

PROPOSAL          1: To elect nine directors to hold office until the 1999
                  Annual Meeting of Stockholders.

[ ]   FOR the nominees listed below              [ ]   WITHHOLD AUTHORITY
      (except as marked to the contrary                to vote for the nominees
      below).                                          listed below.

NOMINEES:   Howard E. Greene, Jr., Virgil Thompson, Robert L. Roe, M.D., James
            C. Paulson, Ph.D., David L. Anderson, William T. Comer, Ph.D.,
            Nicole Vitullo, David L. Mahoney and Nancy D. Rasmussen

TO WITHHOLD AUTHORITY TO VOTE FOR ANY NOMINEE(S) WRITE SUCH NOMINEE(S)' NAME(S)
BELOW:


- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------

                   (Continued and to be signed on other side)

<PAGE>   40

                           (Continued from other side)

MANAGEMENT RECOMMENDS A VOTE FOR PROPOSALS 2, 3, 4 AND 5.

PROPOSAL 2:  To approve the amendment to the Company's Amended and Restated 
             Certificate of Incorporation to increase the Company's authorized
             shares of Common Stock from 50,000,000 shares to 75,000,000 shares.

             [ ]  FOR              [ ]    AGAINST           [ ]     ABSTAIN


PROPOSAL 3:  To approve an option exchange program.

             [ ]  FOR              [ ]    AGAINST           [ ]     ABSTAIN

PROPOSAL 4:  To approve an amendment of the Company's Employee Stock Purchase
             Plan to provide that the aggregate number of shares of Common Stock
             authorized for issuance will be increased from 500,000 shares to
             750,000 shares (an increase of 250,000 shares from 500,000 shares
             previously authorized under the Employee Stock Purchase Plan). 

             [ ]  FOR              [ ]    AGAINST           [ ]     ABSTAIN

PROPOSAL 5:  To approve amendments to the Company's 1989 Stock Option Plan
             (the "1989 Plan") and the Company's 1994 Non-Employee Directors'
             Stock Option Plan (the "Non-Employee Directors' Plan") to provide
             that the aggregate number of shares of Common Stock authorized for
             issuance on a combined basis under both the 1989 Plan and the
             Non-Employee Directors' Plan will be 7,750,000 shares (an increase
             of 1,350,000 shares from 6,400,000 shares previously authorized
             under the 1989 Plan and the Non-Employee Directors Plan).

             [ ]  FOR              [ ]    AGAINST           [ ]     ABSTAIN

PROPOSAL 6:  To ratify selection of ERNST & YOUNG LLP as independent auditors
             of the Company for its fiscal year ending December 31, 1998.

             [ ]  FOR              [ ]    AGAINST           [ ]     ABSTAIN

DATED _________________                 ________________________________________

                                        ________________________________________
                                                       SIGNATURE(S)

                                        Please sign exactly as your name appears
                                        hereon. If the stock is registered in
                                        the names of two or more persons, each
                                        should sign. Executors, administrators,
                                        trustees, guardians and
                                        attorneys-in-fact should add their
                                        titles. If signer is a corporation,
                                        please give full corporate name and have
                                        a duly authorized officer sign, stating
                                        title. If signer is a partnership,
                                        please sign in partnership name by
                                        authorized person.

PLEASE VOTE, DATE AND PROMPTLY RETURN THIS PROXY IN THE ENCLOSED RETURN ENVELOPE
WHICH IS POSTAGE PREPAID IF MAILED IN THE UNITED STATES.





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