EPIMMUNE INC
SC 13G, 1999-07-22
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G


                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                                (AMENDMENT NO.__ )*


                                  EPIMMUNE INC.
                                ----------------
                                (Name of Issuer)


                                  COMMON STOCK
                         ------------------------------
                         (Title of Class of Securities)


                                   29425y 10 1
                                 --------------
                                 (CUSIP Number)


                                  JULY 1, 1999
             -------------------------------------------------------
             (Date of Event Which Requires Filing of This Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|      Rule 13d-1(b)

|X|      Rule 13d-1(c)

|_|      Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

POTENTIAL PERSONS WHO ARE TO RESPOND TO THE COLLECTION OF INFORMATION CONTAINED
IN THIS FORM ARE NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY
VALID OMB CONTROL NUMBER.


                                   Page 1 of 4
<PAGE>


CUSIP No.   29425y 10 1                13G                     Page 2 of 4 Pages


________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)


     Alessandro Sette, Ph.D.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


     Italy
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           324,092
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          -0-
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         324,092
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            -0-
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


     324,092
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


     5.3746%
________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


     IN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


                                  Page 2 of 4
<PAGE>


ITEM 1.
          (a)  Name of Issuer: EPIMMUNE INC.
          (b)  Address of Issuer's Principal Executive Offices: 5820 NANCY RIDGE
               DRIVE, SAN DIEGO, CA 92121

ITEM 2.
          (a)  Name of Person Filing: ALESSANDRO SETTE, PH.D.
          (b)  Address of Principal Business Office or, if none, Residence: 5820
               NANCY RIDGE DRIVE, SAN DIEGO, CA 92121
          (c)  Citizenship: ITALY
          (d)  Title of Class of Securities: COMMON STOCK
          (e)  CUSIP Number: 29425y 10 1

ITEM 3.   IF THIS STATEMENT IS FILED PURSUANT TO ss.ss.240.13d-1(b), OR
          240.13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:
          (a)  |_| Broker or Dealer registered under Section 15 of the Act (15
                   U.S.C. 78o);
          (b)  |_| Bank as defined in section 3(a)(6) of the Act (15 U.S.C.
                   78c);
          (c)  |_| Insurance company as defined in section 3(a)(19) of the Act
                   (15 U.S.C. 78c);
          (d)  |_| An investment company registered under section 8 of the
                   Investment Company Act of 1940 (15 U.S.C. 80a-8);
          (e)  |_| An investment adviser in accordance with
                   ss.240.13d-1(b)(1)(ii)(F);
          (f)  |_| An employee benefit plan or endowment fund in accordance
                   with ss.240.13d-1(b)(1)(ii)(F);
          (g)  |_| A parent holding company or control person in accordance
                   with ss.240.13d-1(b)(ii)(G);
          (h)  |_| A savings association as defined in Section 3(b) of the
                   Federal Deposit Insurance Act (12 U.S.C. 1813);
          (i)  |_| A church plan that is excluded from the definition of an
                   investment company under section 3(c)(14) of the Investment
                   Company Act of 1940 (15 U.S.C. 80a-3);
          (j)  |_| Group, in accordance with ss.240.13d-1(b)(1)(ii)(J)

ITEM 4.   OWNERSHIP
          Provide the following information regarding the aggregate number and
          percentage of the class of securities of the issuer identified in
          Item 1.
          (a)  Amount Beneficially Owned: 324,092 SHARES OF COMMON STOCK,
               INCLUDING 3,430 SHARES ISSUABLE UPON EXERCISE OF OPTIONS HELD BY
               DR. SETTE THAT ARE EXERCISABLE WITHIN 60 DAYS OF JULY 1, 1999.
          (b)  Percent of Class: 5.3746%
          (c)  Number of shares as to which such person has:
               (i)  Sole power to vote or to direct the vote: 324,092
               (ii) Shared power to vote or to direct the vote: -0-
               (iii) Sole power to dispose or to direct the disposition of:
                     324,092
               (iv) Shared power to dispose or to direct the disposition of: -0-

INSTRUCTION: For computations regarding securities which represent a right to
acquire an underlying security see ss.240.13d-3(d)(1).

ITEM 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS
          If this statement is being filed to report the fact that as of the
date hereof the reporting person has ceased to be the beneficial owner of more
than five percent of the class of securities, check the following |_|.

INSTRUCTION:  Dissolution of a group requires a response to this item.

ITEM 6.   OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:
          NOT APPLICABLE
          If any other person is known to have the right to receive or the power
to direct the receipt of dividends from, or the proceeds from the sale of, such
securities, a statement to that effect should be included in response to this
item and, if such interest relates to more than five percent of the class, such
person should be identified. A listing of the shareholders of an investment
company registered under the Investment Company Act of 1940 or the beneficiaries
of employee benefit plan, pension fund or endowment fund is not required.

ITEM 7.   IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
          SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:
          NOT APPLICABLE
          If a parent holding company has filed this schedule, pursuant to Rule
13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the
identity and the Item 3 classification of the relevant subsidiary. If a parent
holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule
13d-1(d), attach an exhibit stating the identification of the relevant
subsidiary.


                                  Page 3 of 4
<PAGE>


ITEM 8.   IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:
          NOT APPLICABLE
          If a group has filed this schedule pursuant to ss.240.13d-1(b)(ii)(J),
so indicate under Item 3(j) and attach an exhibit stating the identity and Item
3 classification of each member of the group. If a group has filed this schedule
pursuant to ss.240.13d-1(c) or ss.240.13d-1(d), attach an exhibit stating the
identity of each member of the group.

ITEM 9.   NOTICE OF DISSOLUTION OF A GROUP:  NOT APPLICABLE
          Notice of a dissolution of a group may be furnished as an exhibit
stating the date of the dissolution and that all further filings with respect to
transactions in the security reported on will be filed, if required, by members
of the group, in their individual capacity. See Item 5.

ITEM 10.  CERTIFICATION
          (a)  The following certification shall be included if the statement is
               filed pursuant to ss.240.13d-1(b):

               By signing below I certify that, to the best of my knowledge and
               belief, the securities referred to above were acquired and are
               held in the ordinary course of business and were not acquired and
               are not held for the purpose of or with the effect of changing or
               influencing the control of the issuer of the securities and were
               not acquired and are not held in connection with or as a
               participant in any transaction having that purpose or effect.

          (b)  The following certification shall be included if the statement is
               filed pursuant to ss.240.13d-1(c):

               By signing below I certify that, to the best of my knowledge and
               belief, the securities referred to above were not acquired and
               are not held for the purpose of or with the effect of changing or
               influencing the control of the issuer of the securities and were
               not acquired and are not held in connection with or as a
               participant in any transaction having that purpose or effect.


                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

           July 20, 1999
- ---------------------------------------
                Date

   /S/ Alessandro Sette, Ph.D.
- ---------------------------------------
            Signature

         Alessandro Sette, Ph.D.
- ---------------------------------------


         The original statement shall be signed by each person on whose behalf
the statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative other than an
executive officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including exhibits. See ss.240.13d-7 for other parties
for whom copies are to be sent.

ATTENTION: INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE FEDERAL
           CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001)



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