IMMUNE RESPONSE INC
DEF 14A, 1997-01-09
NON-OPERATING ESTABLISHMENTS
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                    Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934
                                (Amendment No. )

Filed by the Registrant  [X]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ]  Preliminary Proxy Statement
[ ]  Confidential, for Use of the Commission Only (as permitted by
     Rule 14a-6(e)(2))
[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to ss. 240.14a-11(c) or ss. 14a-12

                              IMMUNE RESPONSE, INC.
                              ---------------------
                (Name of Registrant as Specified In Its Charter)

                             
      --------------------------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if other than Registrant)

Payment of Filing Fee (Check the appropriate Box:)

[X]   No fee required
[ ]   Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and O-11.

      (1) Title of each class of securities to which transaction applies: N/A 
      (2) Aggregate number of securities to which transaction  applies: N/A 
      (3) Per unit price or other underlying value of transaction computed 
          pursuant to Exchange Act Rule O-11:(1)   N/A
      (4) Proposed maximum aggregate value of transaction:  N/A
      (5) Total fee paid:  N/A
- ----------
(1) Set forth the amount on which the filing fee is calculated and state how it 
    was determined.

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange Act Rule 
    O-11(a)(2) and identify the filing for which the offsetting fee was paid 
    previously.  Identify the previous filing by registration statement number, 
    or the Form or Schedule and the date of its filing.
         (1) Amount Previously Paid:  N/A
         (2) Form, Schedule or Registration Statement No.:  N/A
         (3) Filing Party:  N/A
         (4) Date Filed: N/A

<PAGE>

                              IMMUNE RESPONSE, INC.
                            7315 East Peakview Avenue
                            Englewood, Colorado 80111
                                 (303) 796-8940
       -----------------------------------------------------------------

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

                         To Be Held on February 10, 1997

        -----------------------------------------------------------------

                                                                 January 9, 1997

TO ALL SHAREHOLDERS OF IMMUNE RESPONSE, INC.

     An Annual  Meeting of  Shareholders  of Immune  Response,  Inc., a Colorado
corporation  (the "Company") will be held at the Company's  offices at 7315 East
Peakview Avenue, Englewood, Colorado 80111, on  February 10, 1997, at 10:00 a.m.
local time, to consider and take action on the following matters:

         1.       The election of three directors to serve until the next annual
                  meeting of shareholders  and until their  successors have been
                  elected and qualified.

         2.       Approval of two proposals,  each to be voted on separately, to
                  adopt the  following  amendments or additions to the Company's
                  Articles of Incorporation,  as amended (the "Articles"), to be
                  included in the  Company's  Amended and  Restated  Articles of
                  Incorporation:

                  (a) An  amendment  to the  Articles  to  effect a  one-for-100
                  reverse  stock  split and to reduce the  number of  authorized
                  shares of common  stock of the Company  (the  "Common  Stock")
                  from  950,000,000  shares to  25,000,000  shares as  permitted
                  under Section 7-106-105 of the Colorado  Business  Corporation
                  Act.  Fractional shares resulting from the reverse stock split
                  will be rounded to the closest  whole  share of Common  Stock;
                  and

                  (b) An amendment to the Articles to indemnify  the  directors,
                  officers, employees, fiduciaries, and agents of the Company to
                  the full extent  permitted  by  Colorado  law and to limit the
                  personal  liability of the  Company's  directors  for monetary
                  damages for certain  breaches of the fiduciary duty of care as
                  permitted  under  Section  7-108-402 of the Colorado  Business
                  Corporation Act.

         3.       Such other  business as may properly  come before the meeting,
                  or any adjournment or adjournments thereof.

<PAGE>

     Shareholders  holding  shares of Common  Stock of record at the  closing of
business on December 2, 1996,  will be entitled to receive notice of and vote at
the meeting.

     Shareholders,  whether or not they expect to be present at the meeting, are
requested  to sign and date the  enclosed  proxy and return it  promptly  in the
envelope  enclosed for that purpose.  Any person giving a proxy has the power to
revoke  it at any time by  following  the  instructions  provided  in the  Proxy
Statement.


                                       By Order of the Board of Directors:



                                       Joseph W. Hovorka, President


     PLEASE DATE, SIGN AND PROMPTLY RETURN YOUR PROXY SO THAT YOUR SHARES MAY BE
VOTED IN ACCORDANCE  WITH YOUR WISHES.  THE GIVING OF SUCH PROXY DOES NOT AFFECT
YOUR RIGHT TO VOTE IN PERSON IF YOU ATTEND THE MEETING.

                             YOUR VOTE IS IMPORTANT

<PAGE>

                              IMMUNE RESPONSE, INC.
                            7315 East Peakview Avenue
                            Englewood, Colorado 80111
                                 (303) 796-8940

                 -----------------------------------------------

                                 PROXY STATEMENT
                         ANNUAL MEETING OF SHAREHOLDERS
                                FEBRUARY 10, 1997

                 -----------------------------------------------


To Our Shareholders:

     This Proxy  Statement (the "Proxy  Statement") is furnished to shareholders
of Immune Response,  Inc., a Colorado  corporation (the "Company") in connection
with the  solicitation  of  proxies by and on behalf of the  Company's  Board of
Directors  (the "Board") for use at the Annual  Meeting of  Shareholders  of the
Company (the "Meeting") to be held on February 10, 1997 at the Company's offices
located at 7315 East Peakview Avenue, Englewood, Colorado 80111, at the time and
for the  purposes  set forth in the  accompanying  Notice of Annual  Meeting  of
Shareholders.  This Proxy Statement,  the accompanying proxy card and the Notice
of Annual  Meeting  (collectively,  the "Proxy Materials") will be first sent to
shareholders on or about January 9, 1997.

                               GENERAL INFORMATION

     As of the close of  business  on  December  2, 1996,  the  record  date for
entitlement  to  notice  of and vote at the  Annual  Meeting,  the  Company  had
outstanding  294,970,000 shares of common stock, $.0001 par value per share (the
"Common Stock").  The presence,  in person or by proxy, of holders of a majority
of the shares of Common  Stock  entitled  to vote at the Meeting  constitutes  a
quorum for the transaction of business at the Meeting.

     Each share of Common  Stock  outstanding  on the record date is entitled to
one vote on each matter presented at the Meeting. To be elected as a director, a
nominee  must have more shares  cast in his favor than  shares for which  voting
authority is withheld.

     Abstentions  will be treated as shares present or represented  and entitled
to vote for purposes of  determining  the presence of a quorum,  but will not be
considered  as votes cast in  determining  whether a matter has been approved by
the shareholders.  As to any shares a broker indicates on its proxy that it does
not have the  authority  to vote on any  particular  matter  because  it has not
received  direction from the beneficial  owner thereof,  said shares will not be
counted as voting on a particular matter.

<PAGE>

     A  stockholder  who gives his proxy may revoke it at any time  before it is
voted by  giving  notice  of the  revocation  thereof  to the  Secretary  of the
Company,  by filing another proxy with the Secretary or by attending the Meeting
and voting in person.  All properly  executed and  unrevoked  proxies  delivered
pursuant to this solicitation,  if received in time, will be voted in accordance
with the instructions of the beneficial owners contained thereon.

     The  Company  will  bear  the  cost of the  solicitation.  In  addition  to
solicitation  by mail,  the  Company  will  request  banks,  brokers  and  other
custodian  nominees and  fiduciaries to supply proxy materials to the beneficial
owners  of the  Company's  Common  Stock  for whom  they  hold  shares  and will
reimburse them for their reasonable expenses in so doing.


                       PROPOSAL 1 - ELECTION OF DIRECTORS

     The following three persons are nominated as directors of the Company for a
term of one year and until the election and  qualification of their  successors:
Joseph W. Hovorka,  Thomas B. Olson and R. Andrew  Girardot,  Jr., D.D.S.  These
three directors will constitute the entire Board of Directors.  The person named
in the proxy  intends to vote for Messrs.  Hovorka,  Olson and Girardot who have
been  recommended for election by the Board of Directors of the Company unless a
stockholder  withholds authority to vote for any or all of the nominees.  If any
nominee is unable to serve or, for good cause,  will not serve, the person named
in the proxy  reserves the right to substitute  another  person of his choice as
nominee in such nominee's  place.  Each of the nominees has agreed to serve,  if
elected.  The following  table sets forth the names and ages of the nominees and
the  executive  offices  held by each  such  person.  The  Company  has no other
officers. These officers serve at the pleasure of the Board of Directors.

<TABLE>
<CAPTION>
                                                                  First Year
Name                        Age     Offices held                Elected Director
- ----                        ---     ------------                ----------------
<S>                         <C>     <C>                               <C> 
Joseph W. Hovorka           66      President, Treasurer              1987
                                    and Director

Thomas B. Olson             30      Secretary and Director            1990

R. Andrew Girardot, Jr.     53      Director                          1996
</TABLE>

     The  directors  of the Company  are  elected to hold office  until the next
annual meeting of the shareholders  and until their  respective  successors have
been elected and qualified.  Officers of the Company are elected by the Board of
Directors and hold office until their successors are duly elected and qualified.

                                       -2-

<PAGE>

     No  arrangement  exists  between any of the above  officers  and  directors
pursuant  to which  any one of those  persons  was  elected  to such  office  or
position.

     JOSEPH W. HOVORKA.  Mr. Hovorka has served as the Company's President since
February  1990 and has been a Vice  President,  Treasurer  and a director  since
September  1987.  Mr.  Hovorka  has been  President,  Chief  Executive  Officer,
Treasurer  and a director  of  ProConnextions,  Inc.  since  August 1990 and the
Treasurer  and a  director  of Sports  Card  Connection,  Inc.,  a  wholly-owned
subsidiary of ProConnextions,  Inc., since November 1990.  ProConnextions,  Inc.
and Sports Card Connection,  Inc. are privately-held companies which were formed
to buy, trade and sell sports memorabilia. From 1989 to 1993, Mr. Hovorka served
as  President,  Chief  Operating  Officer,  and  Treasurer and was a director of
William's Controls, Inc., a publicly-held manufacturer of pneumatic,  electronic
and  hydraulic  controls  for trucks,  buses,  mining,  construction  and refuse
collection vehicles.  Mr. Hovorka also served as President and was a director of
Enercorp,  Inc., a  publicly-held  business  development  company from July 1986
until June 1993.  From  September  1990  until June 1993 Mr.  Hovorka  served as
President  and  was  a  director  of  Ajay  Sports,   Inc.,  a   publicly-traded
manufacturer  of golf bags and  accessories.  Mr.  Hovorka  had been  engaged in
commercial and business banking for over 30 years. Mr. Hovorka devotes only such
time as is necessary to the affairs of the Company.

     THOMAS B.  OLSON.  Mr.  Olson has been a  Director  since 1988 and has been
Secretary of the Company since 1994. Since 1988, Mr. Olson has been Secretary of
Equitex,   Inc.,  a  publicly-held  business  development  company  which  is  a
shareholder of the Company.  Mr. Olson has attended Arizona State University and
the  University  of Colorado at Denver.  Mr. Olson  devotes only such time as is
necessary to the affairs of the Company.

     R. ANDREW  GIRARDOT,  JR.,  D.D.S.  Dr.  Girardot  became a director of the
Company in November  1996.  Since 1972,  Dr.  Girardot has been President of his
solo orthodontic practice, R. Girardot,  Jr., D.D.S., P.C. in Denver,  Colorado.
Dr. Girardot is also currently serving the cleft palate clinic at the Children's
Hospital in Denver,  Colorado.  Dr.  Girardot  graduated  from the University of
California  Orthodontic  School  in  1972  and  is  a  member  of  the  American
Association of  Orthodontists,  the American Dental Society,  The Foundation for
Orthodontic Research,  the American Equilibration Society, The Angle Society and
the Foundation for Advanced Continuing Education.

     There are no family relationships  between any Director,  Executive Officer
or Nominees for director of the Company.

                                       -3-

<PAGE>

                             EXECUTIVE COMPENSATION

Summary Compensation Table
- --------------------------

     The following  table sets forth a summary of the  compensation  paid to the
current executive officers listed above for each of the last three fiscal years.

<TABLE>
<CAPTION>
(a)                    (b)            (c)            (d)           (e)              (g)            (i)
Name &                                                             Other                           All
Principal                                                          Annual           Options        Other
Position               Year           Salary         Bonus         Compensation     & SARs         Compensation
                                       ($)            ($)              ($)            ($)            (#)($)
- -----------------------------------------------------------------------------------------------------------------
<S>                    <C>            <C>              <C>              <C>            <C>              <C>
Joseph W. Hovorka      1996           18,000(1)        0                0              0                0
President,
Treasurer
Principal
Executive
Officer and
Accounting
Officer

Joseph W. Hovorka      1995           18,000(1)        0                0              0                0

Joseph W. Hovorka      1994           18,000(1)        0                0              0                0
</TABLE>

(1) Although Mr. Hovorka is to receive a salary of $18,000 per year, Mr. Hovorka
    has agreed to suspend payment or accrual of such salary.

     The  Company has no stock  options or SARs  outstanding  and no  restricted
stock award or long term incentive plans.

Compensation of Directors
- -------------------------

     Each member of the Company's Board of Directors, Messrs. Joseph W. Hovorka,
Thomas B. Olson and R.  Andrew  Girardot,  Jr.,  receive  $400 for each Board of
Director's  meeting  attended.  For the year ended  December 31,  1995,  Messrs.
Hovorka  and Olson each were  eligible to receive  $1,600 for the four  meetings
held.  Payment is made to  directors  as cash flow  permits.  Each member of the
Board  of  Directors  also  receives  reimbursement  for  expenses  incurred  in
attending board meetings.

                                       -4-

<PAGE>

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

Security Ownership of Certain Beneficial Owners 
and Security Ownership of Management.
- -----------------------------------------------

     The following table contains information as of December 10, 1996, as to the
beneficial ownership of shares of the Company's Common Stock by each person who,
to the knowledge of the Company at that date,  was (i) the  beneficial  owner of
five percent or more of the  outstanding  shares of the class,  (ii) each person
who is a director or nominee for director of the Company,  (iii) each person who
is an executive officer of the Company,  and (iv) all persons as a group who are
officers and directors of the Company,  and as to the  percentage of outstanding
shares so held by them on December 10, 1996.

<TABLE>
<CAPTION>
Name and address                    Amount and Nature of             Percent
of beneficial owner                 Beneficial Ownership             of Class
- -------------------                 --------------------             --------
<S>                                     <C>                           <C> 
Joseph W. Hovorka                              -0-                     0.0%
7315 East Peakview Avenue
Englewood, Colorado  80111

Thomas B. Olson                         10,000,000(1)                  3.4%
7315 East Peakview Avenue
Englewood, Colorado  80111

R. Andrew Girardot, Jr., D.D.S.                -0-                     0.0%
4380 South Syracuse Circle
Suite 501
Denver, Colorado  80237

Henry Fong                              47,750,000(2)                 16.2%
7315 East Peakview Avenue
Englewood, Colorado  80111

All executive officers and              10,000,000(1)                  3.4%
directors as a group (three
persons)
</TABLE>

The beneficial owners exercise sole voting and investment power.

(1)  Includes 10,000,000 shares owned by Equitex, Inc. of which Mr. Olson is the
     Secretary. Mr. Olson disclaims beneficial ownership of these securities.

(2)  Included 10,000,000 shares owned  by Equitex, Inc. of which Mr. Fong is the
     President. Mr. Fong disclaims beneficial ownership of these securities.

                                       -5-

<PAGE>

Compliance with Section 16 of the Securities Act of 1934
- --------------------------------------------------------

     Section  16(a)  of the  Securities  Exchange  Act of  1934  ("Section  16")
requires the  Company's  officers,  directors  and persons who own more than ten
percent of the Company's  voting  securities to file reports of their  ownership
and changes in such ownership with the Securities and Exchange  Commission  (the
"Commission"). Commission regulations also require that such persons provide the
Company with copies of all Section 16 reports they file.

     Based  solely on  review  of the  copies  of such  forms  furnished  to the
Company,  or written  representations of the reporting persons,  the Company has
determined that all required reports were timely filed during the year.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

Transactions with Management and Others
- ---------------------------------------

     The  Company  currently  utilizes  approximately  150 square feet of office
space in Greenwood Executive Park, 6400 South Quebec, Englewood,  Colorado, from
Equitex,  Inc.,  a  shareholder  of the Company,  on a rent free  month-to-month
basis. The Company's  Secretary and a Director,  Mr. Olson, is also Secretary of
Equitex, Inc.

     During the year ended  December  31,  1995 as in previous  years,  Equitex,
Inc., a significant  shareholder of the Company of which the Company's Secretary
is also an officer,  loaned  $10,000 to the Company.  When added to the previous
years' balance,  the total loans  outstanding at December 31, 1995 were $76,100.
These loans are due on demand and carry an interest rate of 10% per annum. Total
interest due at December 31, 1995 on these loans was $35,703.  To date,  none of
the total outstanding loans or interest due has been repaid.

     During the year ended December 31, 1994 as in previous  years,  the Company
incurred  legal costs from an attorney who was a former  officer and director of
the Company in the amount of $1,823 for 1994 and $11,025 for 1993. The aggregate
amount due to the former  officer and  director  for legal fees at December  31,
1995 was $52,062. The entire amount was repaid during the first quarter of 1996.

Audit, Nominating and Compensation Committees
- ---------------------------------------------

     The Company  does not have a standing  audit,  nominating  or  compensation
committees of the Board of Directors, or any other committees performing similar
functions.

Meetings of the Board of Directors
- ----------------------------------

     During the last full fiscal  year,  the  Company  had four  meetings of the
board of directors.

                                       -6-

<PAGE>

                                   PROPOSAL 2


         ADOPT THE AMENDED AND RESTATED ARTICLES OF INCORPORATION

     The Board of Directors has approved and  recommends  that the  shareholders
approve the following amendments to the Company's Articles of Incorporation,  as
amended (the  "Articles").  It is the Company's intent to incorporate all of the
amendments  set forth in this  proposal  which are approved by the  shareholders
into  Amended  and  Restated  Articles  of  Incorporation  of the  Company  (the
"Restated Articles") to be filed with the Colorado Secretary of State.

     The amendments proposed are (1) to effect a one-for-100 reverse stock split
and to reduce the number of authorized  shares of Common Stock from  950,000,000
shares to 25,000,000 shares as permitted under Section 7-106-105 of the Colorado
Business  Corporation  Act;  and  (2)  to  indemnify  the  directors,  officers,
employees,  fiduciaries,  and agents of the Company to the full extent permitted
by Colorado law and to limit the personal  liability of the Company's  directors
for  monetary  damages for certain  breaches  of the  fiduciary  duty of care as
permitted under Section 7-108-402 of the Colorado Business Corporation Act.

     The  following  discussion  is qualified in its entirety by the text of the
proposed  Restated  Articles  attached  hereto  as  Exhibit  A.  If  any  of the
amendments proposed herein are not approved by the shareholders, prior to filing
the Restated  Articles  with the Colorado  Secretary of State,  the Company will
revise the Restated Articles to reflect the comparable  provision of its current
Articles of Incorporation.

A.       AN AMENDMENT TO ARTICLE V OF THE COMPANY'S ARTICLES TO
         EFFECT A ONE-FOR-100 REVERSE STOCK SPLIT AND TO REDUCE THE
         NUMBER OF AUTHORIZED SHARES FROM 950,000,000 SHARES TO
         25,000,000 SHARES

     The Board of  Directors  has  adopted a  resolution,  pursuant  to  Section
7-106-105(6)(a)  of the  Colorado  Business  Corporation  Act,  recommending  an
amendment to Article V of the  Articles to effect a  one-for-100  reverse  stock
split of the presently  issued and  outstanding  shares of the Common Stock (the
"Reverse Stock  Split"),  as permitted  under Section  7-106-105 of the Colorado
Business Corporation Act. Pursuant to the terms of the Reverse Stock Split, each
holder of record of Common  Stock on the  effective  date of the  Reverse  Stock
Split will  thereafter be deemed to hold one share of Common Stock for every 100
shares of  presently  issued and  outstanding  of Common Stock held of record on
that date.  Fractional  shares  resulting  from the Reverse  Stock Split will be
rounded to the  closest  whole share of Common  Stock.  In  connection  with the
Reverse Stock Split, the authorized  shares of the Company would be reduced from
950,000,000 to 25,000,000.

                                       -7-

<PAGE>

Text of the Amendment
- ---------------------

     The Articles shall be amended by replacing in its entirety the current text
of Article V so that there appears the following text:

                                    ARTICLE V

                                  CAPITAL STOCK

                  The  aggregate  number  of  shares  and the  amount  of  total
         authorized  capital of the Company shall consist of 950,000,000  shares
         of $.0001 par value common stock.

                  As of the date upon which these Amended and Restated  Articles
         of Incorporation become effective, each 100 shares of authorized $.0001
         par common  stock,  whether or not  issued  and  outstanding,  shall be
         converted into one share of $.0001 par common stock.  Fractional shares
         resulting  from the Reverse  Stock Split will be rounded to the closest
         whole share of Common  Stock.  Following  this reverse  stock split the
         number of shares of $.0001 par common stock which the Company  shall be
         authorized to issue shall be 25,000,000.

                  The holders of Common  Stock shall have and possess all rights
         as shareholders of the corporation.

                  The capital stock,  after the amount of the subscription price
         has been  paid in,  shall not be  subject  to  assessment  or any other
         liability to pay the debts of the corporation.

                  Any  stock  of  the  corporation  may  be  issued  for  money,
         property,   services  rendered,  labor  done,  cash  advances  for  the
         corporation,  for any  other  assets  of value in  accordance  with the
         action  of the Board of  Directors,  or other  consideration  permitted
         under the Colorado Business  Corporation Act. The judgment of the Board
         of Directors as to value  received in return for the issuance of shares
         shall be conclusive and said shares,  when issued,  shall be fully paid
         and nonassessable.

Purpose of the Reverse Stock Split
- ----------------------------------

     The Board of Directors  believes  that the Reverse Stock Split is advisable
and in the best  interests of the Company and its  shareholders.  In discussions
between the  Company's  executive  officers  with members of the  brokerage  and
investment banking industries, the Company has been advised that brokerage firms
might be more  willing  to  evaluate  the  Company's  securities  as a  possible
investment  opportunity  for their  clients and may be more  willing to act as a
market maker in the Company's securities if the price range for the Common Stock
were  higher.  Management  believes  that  additional interest by the investment

                                       -8-

<PAGE>

community in the Common Stock, of which there can be no assurance,  is desirable
and could result in a more stable trading market for the Common Stock.

     The Company also believes  that  existing low trading  prices of the Common
Stock may have an adverse impact on the current  efficient  level of the trading
market for the Common Stock. In particular,  brokerage firms often charge higher
commissions for transactions involving low-priced stocks than they would for the
same dollar amount of securities  with a higher per share price.  Some brokerage
firms will not recommend purchases of low-priced stocks to their clients or make
a market in such stocks, which tendencies may adversely affect the liquidity for
current   shareholders  and  Company's   ability  to  obtain  additional  equity
financing.

     There can be no assurance  that the Reverse  Stock Split will not adversely
impact  the market  price of the Common  Stock,  that the  marketability  of the
Common  Stock will improve as a result of the Reverse  Stock Split,  or that the
Reverse Stock Split will otherwise have any of the effects described herein.

Effect of the Reverse Stock Split
- ---------------------------------

     The  principal  effect of the Reverse  Stock Split will be to decrease  the
number of issued and outstanding  shares of the Common Stock from 294,970,000 to
approximately  3,000,000 shares. The Common Stock issued pursuant to the Reverse
Stock Split will be fully paid and  nonassessable.  The voting  rights and other
rights that accompany the Common Stock prior to the Reverse Stock Split will not
be altered by the Reverse Stock Split.

Certificates and Fractional Shares
- ----------------------------------

     The certificates  currently  representing  issued and outstanding shares of
Common  Stock  will be deemed to  represent  100 the  number of shares of Common
Stock after the effective date of the Reverse Stock Split.  New shares of Common
Stock, par value $.0001, will be issued in due course as old shares are tendered
to the transfer agent for exchange or transfer. Fractional shares resulting from
the Reverse  Stock  Split will be rounded to the  closest  whole share of Common
Stock.

     Shareholders are not required to exchange their certificate(s) of pre-split
Common Stock for post-split Common Stock.  Shareholders  may, however,  exchange
their  certificates for shares of post-split Common Stock by surrendering  their
old certificates  representing shares of pre-split Common Stock to the Company's
transfer agent. Upon surrender to the transfer agent of the share certificate(s)
representing  shares of pre-split Common Stock and the applicable  transfer fee,
which  presently  is $12.00 per  certificate,  the holder  will  receive a share
certificate  representing the appropriate  number of shares of post-split Common
Stock.

                                       -9-

<PAGE>



Effective Date of the Reverse Stock Split
- -----------------------------------------

     The Reverse Stock Split will become  effective on the effective date of the
Amendment to the Articles,  which is expected to be filed as soon as practicable
after the annual shareholders' meeting (the "Effective Date"). Holders of record
of the  Common  Stock at the close of  business  on the  Effective  Date will be
entitled to receive one share of Common Stock for 100 shares then held.

Transfer Agent
- --------------

     The transfer agent for the Common Stock is Corporate Stock Transfer, Inc.

Federal Income Tax Consequences of the Reverse Stock Split
- ----------------------------------------------------------

     Any tax liability to  shareholders  resulting  from the Reverse Stock Split
will  likely not be  substantial.  The shares of Common  Stock  received  in the
Reverse  Stock  Split  should  not  result  in  any  taxable  gain  or  loss  to
shareholders for federal income tax purposes.  The tax basis of the Common Stock
received by  shareholders  as a result of the Reverse Stock Split will be equal,
in the aggregate, to the basis of the shares exchanged for the Common Stock. For
tax  purposes,  the  holding  period  of the  shares  immediately  prior  to the
effective date of the Reverse Stock Split will be included in the holding period
of the Common Stock received as a result of the Reverse Stock Split.

Votes Required and Recommended
- ------------------------------

     Approval of the  proposal  for the Company to amend the  Articles to effect
the  Reverse  Stock  Split and to reduce the number of  authorized  shares  from
950,000,000  shares  to  25,000,000  shares  requires  the  affirmative  vote of
two-thirds of the outstanding shares of the Company's Common Stock. THE BOARD OF
DIRECTORS OF THE COMPANY  RECOMMENDS THAT SHAREHOLDERS VOTE FOR THE PROPOSAL FOR
THE  COMPANY TO AMEND THE  ARTICLES  TO EFFECT THE  REVERSE  STOCK  SPLIT AND TO
REDUCE THE NUMBER OF  AUTHORIZED  SHARES FROM  950,000,000  SHARES TO 25,000,000
SHARES.  Unless otherwise specified,  the enclosed proxy will be voted "FOR" the
approval of the amendment.

B.      AN  AMENDMENT  TO THE  ARTICLES TO LIMIT THE  PERSONAL  LIABILITY OF THE
        COMPANY'S  DIRECTORS  FOR MONETARY  DAMAGES FOR CERTAIN  BREACHES OF THE
        FIDUCIARY  DUTY OF CARE AS  PERMITTED  UNDER  SECTION  7-108-402  OF THE
        COLORADO  BUSINESS  CORPORATION  ACT AND TO  INDEMNIFY  THE OFFICERS AND
        DIRECTORS  TO  THE  FULL  EXTENT  PERMITTED  BY  THE  COLORADO  BUSINESS
        CORPORATION ACT

     The Board of Directors  has adopted a resolution  to add Articles  XIII and
XIV to the Articles, or, in order to indemnify directors,  officers,  employees,
fiduciaries, and agents of the Company to the full  extent permitted by Colorado

                                      -10-

<PAGE>

law (the  "Indemnity  Amendment")  and to limit the  personal  liability  of the
Company's  directors for monetary  damages for certain breaches of the fiduciary
duty of care as permitted  under  Section  7-108-402  of the  Colorado  Business
Corporation Act (the "Liability  Amendment").  The Colorado Business Corporation
Act permits a Colorado  corporation the power to indemnify a director,  officer,
employee,  fiduciary,  or agent of the corporation  provided that (1) the person
conducted  himself in good  faith and (2) the person was acting in his  official
capacity with the corporation  and reasonably  believed his conduct was at least
not  opposed  to  the  corporation's  best  interests.   The  Colorado  Business
Corporation  Act also permits a Colorado  corporation  to limit or eliminate the
personal  monetary  liability  of  its  directors  to  the  corporation  or  its
shareholders  by  reason  of  their  breach  of the  fiduciary  duty  of care as
directors,   including  liability  for  negligence,  and  gross  negligence,  by
including a provision to this effect in its Articles.

Text of the Indemnity and Liability Amendments

     The Articles shall be amended by adding Articles XIII and XIV so that there
appears the following text:

                                  ARTICLE XIII

                          INDEMNIFICATION OF DIRECTORS
                   OFFICERS, EMPLOYEES, FIDUCIARIES AND AGENTS


                   To the  fullest  extent  provided  by  applicable  state law,
        including,  but not limited to, the Colorado  Business  Corporation Act,
        each director, officer, employee,  fiduciary or agent of the Corporation
        (and his heirs,  executors and  administrators)  shall be indemnified by
        the Corporation  against expenses reasonably incurred by or imposed upon
        him in connection with or arising out of any action,  suit or proceeding
        in which he may be involved or to which he may be made a party by reason
        of his being or having been a director, officer, employee,  fiduciary or
        agent of the Corporation,  or at its request of any other corporation of
        which it is a shareholder  or creditor and from which he is not entitled
        to be  indemnified  (whether  or  not  he  continues  to be a  director,
        officer,  employee,  fiduciary  or  agent  at the  time of  imposing  or
        incurring such expenses).  The foregoing right of indemnification  shall
        not be  exclusive  of other  rights  to which he may be  entitled  under
        applicable state law.

                                   ARTICLE XIV

                            LIMITATIONS OF LIABILITY

                  A director of the corporation  shall not be personally  liable
         to the corporation or its  shareholders for monetary damages for breach
         of fiduciary duty


                                      -11-

<PAGE>



          as a director; except that this provision shall not eliminate or limit
          the liability of a director to the corporation or its shareholders for
          monetary  damages  otherwise  existing  for  (i)  any  breach  of  the
          director's  duty of loyalty to the  corporation  or its  shareholders;
          (ii) acts or omissions not in good faith or which involve  intentional
          misconduct  or a knowing  violation  of law;  (iii) acts  specified in
          Section  7-108-403 of the Colorado  Business  Corporation Act; or (iv)
          any transaction from which the director directly or indirectly derived
          any improper  personal benefit.  If the Colorado Business  Corporation
          Act is hereafter  amended to eliminate or limit  further the liability
          of a director,  then, in addition to the elimination and limitation of
          liability  provided by the preceding  sentence,  the liability of each
          director  shall  be  eliminated  or  limited  to  the  fullest  extent
          permitted by the Colorado Business  Corporation Act as so amended. Any
          repeal or modification of this Article XIV by the  shareholders of the
          corporation  shall not  adversely  affect any right or protection of a
          director  of the  corporation  under this  Article  XIV,  as in effect
          immediately  prior to the repeal or modification,  with respect to any
          liability that would have accrued,  but for this Article XIV, prior to
          the repeal or modification.

The Indemnity Amendment

     The  Colorado  Business  Corporation  Act  provides  for a  corporation  to
indemnify  and advance  expenses to its  directors  and officers  under  certain
circumstances,   as  described   more  fully  below,   unless   limited  by  the
corporation's  articles of  incorporation.  In addition,  the Colorado  Business
Corporation  Act  specifies  that a  corporation  may evidence the extent of its
intent to  indemnify  or advance  expenses  to  directors  and  officers  in its
articles of incorporation, bylaws, a resolution of its directors or shareholders
or in a contract;  provided, however, that the indemnification of or advancement
of expenses to directors  and officers  shall be valid only if and to the extent
such  is  consistent  with  the  Colorado  Business   Corporation  Act  and  the
corporation's articles of incorporation, to the extent limited therein.

     The Colorado Business Corporation Act requires that a corporation indemnify
a director or officer who is wholly successful,  on the merits or otherwise,  in
defense of any Proceeding (as defined  below),  to which he is a party,  against
reasonable expenses, including attorney fees, incurred by him in connection with
the  proceeding.  A  "Proceeding"  means any  threatened,  pending or  completed
action,  suit,  or  proceeding,  whether  civil,  criminal,   administrative  or
investigative and whether formal or informal.

     In addition, the Colorado Business Corporation Act permits a corporation to
indemnify  a director  against  Liability  (as  defined  below)  incurred in any
Proceeding to which the director is made a party because he is or was a director
if the director:  (a) conducted  himself in good faith; (b) reasonably  believed
that (i) if the conduct was in his official capacity with the corporation,  that
said conduct was in the corporation's best interest,  or (ii) if the conduct was
not in his  official  capacity  with the  corporation,  that said conduct was at
least not opposed to the corporation's best interests; and (c) had no reasonable

                                      -12-

<PAGE>

cause to believe  his  conduct was  unlawful  if the  Proceeding  is criminal in
nature. "Liability" means the obligation to pay a judgment, settlement, penalty,
fine  (including  an excise tax  assessed  with  respect to an employee  benefit
plan), and reasonable  expenses,  including attorney fees, incurred with respect
to the Proceeding.

     The Colorado  Business  Corporation Act also provides  circumstances  under
which a corporation may not indemnify its directors and officers.  A corporation
may not indemnify a director or officer in connection with any proceeding (a) by
or in the right of the  corporation in which the director or officer is adjudged
liable to the  corporation,  or (b) charging  improper  personal  benefit to the
director or officer,  whether or not involving action in his official  capacity,
in which the director or officer is adjudged  liable on the basis that  personal
benefit was improperly received by him.

     Under the Colorado  Business  Corporation Act, a corporation may pay for or
reimburse  the  reasonable  expenses  incurred by a director or officer who is a
party to a Proceeding in advance of the final  disposition  of the Proceeding if
the director or officer (a) furnishes the  corporation a written  affirmation of
his  good  faith  belief  that,  with  respect  to the  conduct  subject  of the
Proceeding,  he conducted  himself in good faith;  (b) furnishes the corporation
with a written  undertaking to repay the advance if it is determined that he did
not meet such standard of conduct (i.e. he did not act in good faith); and (c) a
determination   is  made  that  the  facts  then  known  to  those   making  the
determination  would not preclude  indemnification  under the Colorado  Business
Corporation Act.

The Liability Amendment

     In performing their duties,  the Company's  directors are scrutinized under
the "business  judgment rule" which  stipulates the fiduciary duties of care and
loyalty imposed upon directors.  Under the business judgment rule, a director is
required  to  perform  his duties as a director  in good  faith,  in a manner he
reasonably  believes to be in the best  interests of the  corporation,  and with
such care as an ordinarily  prudent  person in a like  position  would use under
similar circumstances.

     The "duty of care" requires that each director act in a manner which, after
a  reasonable  investigation,  he  believes  in  good  faith  to be in the  best
interests  of the Company and all of its  shareholders  and  requires  that each
director,  in the  performance of his corporate  responsibilities,  exercise the
care that an ordinary prudent person would exercise under similar circumstances.
The "duty of loyalty" prohibits  faithlessness and self-dealing by directors and
prohibits  directors  from using  their  corporate  position  to make a personal
profit or gain other personal advantage.

     In recent years,  litigation  seeking to impose  liability on directors and
officers of  publicly-held  corporations  for violations of the duty of care has
become commonplace. To avoid liability, the director is required to show that he
conducted himself in strict compliance with the duty of care as set forth in the
business judgment rule. In practice, the application of this duty varies  widely

                                      -13-

<PAGE>

among the courts,  leaving  directors  with little  guidance and certainty as to
what constitutes  adequate care under a given set of circumstances.  Compounding
this uncertainty,  in several decisions,  courts imposed a clairvoyant duty upon
directors,  despite the fact that the  actions of the  directors  in  exercising
reasonable  care  are  supposed  to be  judged  as of the  time  and  under  the
circumstances existing at the time the decision was made.

     This type of  litigation  is  expensive  to defend,  with costs  frequently
amounting to hundreds of thousands,  and sometimes millions of dollars.  In many
cases,  costs of defense  exceed  the means of  individual  defendants,  even if
ultimately  they  are  vindicated  on  the  issue  of  individual  liability  or
wrongdoing.  In addition,  in view of the costs and uncertainties of litigation,
it is often prudent to settle such claims. While settlements  frequently are for
only a fraction of the amount claimed, the settlement amount may well exceed the
financial resources of individual defendants. In summary, without the benefit of
protective  measures  such as  indemnification  and  limitation  of liability as
permitted under the Colorado Business Corporation Act, exposure to the costs and
risks of claims of personal  liability  for  corporate  directors may exceed any
benefit to them of serving as a director of a public corporation.

     The risks of  personal  liability  for  directors  has  traditionally  been
mitigated   through   directors'  and  officers'   liability   insurance   ("D&O
Insurance").  Changes in the market for D&O  Insurance  during recent years have
resulted in meaningful coverage becoming  unavailable for directors and officers
of many corporations. Insurance carriers have in certain cases declined to renew
existing  directors'  and  officers'  liability  policies,   or  have  increased
premiums,  thereby  making the cost of  obtaining  such  insurance  prohibitive.
Moreover,  policies  often  exclude  coverage  for areas  where the  service  of
qualified  independent  directors is most needed. For example,  many policies do
not  cover  liabilities  or  expenses  arising  from  directors'  and  officers'
activities in response to attempted takeovers of a corporation.

     In  response  to  the  above  developments   regarding  litigation  against
directors  and the general  unavailability  of  meaningful  D&O  Insurance,  the
Colorado   legislature  adopted  Section  7-108-402  of  the  Colorado  Business
Corporation  Act which permits a corporation  to limit or eliminate the personal
monetary  liability  of a director  for  certain  breaches  of the duty of care.
Effectively,  the limitation  acts as a substitute  for, or a supplement to, D&O
Insurance coverage.

     In the opinion of the Board of  Directors,  inclusion  of a  provision  for
limitation of liability  and  continuation  of the Company's  policy of entering
into  indemnification  agreements  with its  directors  will best  position  the
Company to attract and retain  qualified  candidates to serve as its  directors.
Although the Company has not experienced difficulty finding qualified candidates
to serve on its Board of Directors to date, it believes  that it may  experience
difficulty in the future if protective measures are not taken.

     This provision will prevent the Company and its shareholders, but not third
parties,  from  bringing  actions for monetary  damages  based upon a director's
negligent or grossly negligent  business  decisions,  including those related to
attempts  to change control of  the Company, to the benefit  of the Board and at

                                      -14-

<PAGE>

the  expense of the  shareholders.  Thus,  under the  Liability  Amendment,  the
Company or a shareholder  will be able to prosecute an action against a director
for monetary  damages for breach of fiduciary  duty only if it can be shown that
such damages  have been caused by a breach of the duty of loyalty,  a failure to
act in good faith,  intentional misconduct, a knowing violation of law, a direct
or indirect improper personal benefit, or an illegal distribution.  It would not
limit or  eliminate  the  right of the  Company  or any  shareholder  to seek an
injunction or any other  non-monetary  relief if a director breaches his duty of
care. Although equitable remedies remain available,  they may be inadequate as a
practical matter.

     The  provision for the  limitation of liability  proposed to be included in
the Articles is intended to be effective only against actions by the Company and
its  shareholders.  Third  party  plaintiffs,  such as  creditors,  will  not be
prevented from  recovering  damages on the basis of the provision.  In addition,
the provision  would apply only to claims against a director  arising out of his
status as a director and would not apply to claims arising from his status as an
officer or his status in any other capacity;  nor would it apply to a director's
responsibilities  under any other law, such as the federal  securities  laws. If
this proposed provision is approved, changes in Colorado law further limiting or
eliminating  personal  liability of directors  automatically  will be applicable
without further shareholder approval.

     Neither the Board of Directors nor any of its members have  experienced any
recent  litigation  which would have been affected by the above provision had it
been in effect  previously.  The  Liability  Amendment  is not the result of any
pending or threatened  litigation  against any member of the Company's  Board of
Directors.

     The Liability  Amendment will NOT permit any limitation  upon the liability
of a director  for: (i) any breach of his duty of loyalty to the Company and its
shareholders,  (ii)  acts  or  omissions  not in good  faith  or  which  involve
intentional  misconduct  or a knowing  violation of law,  (iii)  assenting to an
unlawful  distribution  made in violation  of section  7-106-401 of the Colorado
Business Corporation Act or the Articles,  or (iv) any transaction from which he
directly or indirectly  derived an improper personal benefit.  Accordingly,  the
provisions limiting or eliminating the potential monetary liability of directors
permitted by the Colorado  Business  Corporation  Act apply only to the "duty of
care" of directors. The provision is not retroactive to limit liability for acts
or omissions occurring prior to the date of its adoption by shareholders.

Votes Required and Recommended
- ------------------------------

     Approval of the Liability  Amendment and the Indemnity  Amendment  requires
the affirmative  vote of two-thirds of the  outstanding  shares of the Company's
Common Stock. THE BOARD OF DIRECTORS OF THE COMPANY RECOMMENDS THAT SHAREHOLDERS
VOTE FOR THE  LIABILITY  AMENDMENT  AND INDEMNITY  AMENDMENT.  Unless  otherwise
specified,  the  enclosed  proxy  will  be  voted  "FOR"  the  approval  of  the
amendments.

                                      -15-

<PAGE>

                         INDEPENDENT PUBLIC ACCOUNTANTS

     The Company's  financial  statements for the fiscal year ended December 31,
1995 were audited by Davis & CO., CPA's, P.C. ("Davis").  The Board of Directors
has selected Davis as the Company's  independent public accountants for the year
ending December 31, 1996. Representatives of Davis are expected to be present at
the Meeting and will have an  opportunity  to make a statement if they desire to
do so, and to be available to respond to appropriate questions.


                              SHAREHOLDER PROPOSALS

     All  proposals  of  shareholders  intended  to be  included  in  the  proxy
statement  to be presented at the next annual  meeting of  shareholders  must be
received  at the  Company's  corporate  offices  at 7315 East  Peakview  Avenue,
Englewood, Colorado 80111,  Attention: Corporate Secretary, on or before May 15,
1997.


                                 OTHER BUSINESS

     Management  of the Company  knows of no other  matter which may come before
the Annual Meeting. However, if any additional matters are properly presented at
the Annual  Meeting,  it is intended that the person named in the enclosed Proxy
Statement,  or his  substitute,  will vote  such  Proxy in  accordance  with his
judgment on such matters.


                                       By Order of the Board of
                                       Directors:

                                       IMMUNE RESPONSE, INC.




Date:  January 9, 1997                 Joseph W. Hovorka, President


                                      -16-
<PAGE>
- ------------------------------------------------------------------------------
                                      PROXY
- ------------------------------------------------------------------------------

                              IMMUNE RESPONSE, INC.
                            7315 East Peakview Avenue
                            Englewood, Colorado 80111
                                 (303) 796-8940

                         ANNUAL MEETING OF SHAREHOLDERS
                         TO BE HELD ON FEBRUARY 10, 1997

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     KNOW ALL MEN BY THESE PRESENTS:  That the undersigned shareholder of Immune
Response,  Inc., a Colorado corporation (the "Company"),  hereby constitutes and
appoints Joseph W. Hovorka with the power to appoint his substitute,  to appear,
attend and vote all of the shares of the Common Stock of the Company standing in
the name of the  undersigned at the Annual Meeting of Shareholders to be held at
the Company's offices at 7315 East Peakview,  Avenue Englewood,  Colorado 80111,
on February 10, 1997, at 10:00 a.m.,  Mountain Time, and at any postponements or
adjournments thereof on the following matters.

         1. ELECTION OF DIRECTORS

__ FOR the nominees listed below                __ WITHHOLD AUTHORITY to vote
   (EXCEPT AS MARKET TO THE CONTRARY)              for nominees listed below

(INSTRUCTION:  TO  WITHHOLD  AUTHORITY  TO VOTE FOR EITHER  INDIVIDUAL  NOMINEE,
STRIKE A LINE THROUGH THE NOMINEE'S NAME IN THE LIST BELOW)

Nominees:  Joseph W. Hovorka * Thomas B. Olson * R. Andrew Girardot, Jr. D.D.S.

         2.       The following amendments to the Company's Articles of 
Incorporation to be included in the Company's Amended and Restated Articles of 
Incorporation.

         (a)      To effect a one-for-100  reverse stock split and to reduce the
                  number of authorized shares of the common stock of the Company
                  (the "Common  Stock") from  950,000,000  shares to  25,000,000
                  shares,  as permitted under Section  7-106-105 of the Colorado
                  Business Corporation Act. Fractional shares resulting from the
                  reverse stock split will be rounded to the closest whole share
                  of Common Stock.

                  FOR  _______      AGAINST  _______      ABSTAIN  _______


<PAGE>

         (b)      To indemnify the directors, officers, employees,  fiduciaries,
                  and agents of the  Company  to the full  extent  permitted  by
                  Colorado  law  and to  limit  the  personal  liability  of the
                  Company's  directors for monetary damages for certain breaches
                  of the  fiduciary  duty  of care as  permitted  under  Section
                  7-108-402 of the Colorado Business Corporation Act.

                  FOR  _______      AGAINST  _______      ABSTAIN  _______

         3.       To transact such other business as may properly come before 
                  the Meeting.

     THIS  PROXY WHEN  PROPERLY  EXECUTED  WILL BE VOTED IN THE MANNER  DIRECTED
HEREIN BY THE UNDERSIGNED SHAREHOLDER.  IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR EACH NOMINEE SET FORTH IN PROPOSAL NO. 1, FOR PROPOSAL NO. 2(A) AND
FOR  PROPOSAL  NO.  2(B).  

     Please  mark,  date and sign your name  exactly  as it  appears  hereon and
return  this Proxy in the  enclosed  envelope as  promptly  as  possible.  It is
important to return this Proxy  properly  signed in order to exercise your right
to vote if you do not attend the  meeting  and vote in person.  When  signing as
agent,  partner,  attorney,  administrator,  guardian,  trustee  or in any other
fiduciary or official  capacity,  please  indicate your title.  If stock is held
jointly, each joint owner must sign.

Date:  ____________, 1997
                                        ----------------------------------------
                                        Signature(s)

                                        Address if different from that on label:

                                        ----------------------------------------
                                        Street Address

                                        ----------------------------------------
                                        City, State and Zip Code

                                        ----------------------------------------
                                        Number of shares

Please check if you intend to be present at the meeting:  ______


                              AMENDED AND RESTATED
                            ARTICLES OF INCORPORATION
                                       OF
                              IMMUNE RESPONSE, INC.


     These Amended and Restated  Articles of Incorporation  were approved by the
shareholders  of IMMUNE  RESPONSE,  INC. on February  7,  1997 and the number of
shares voted for these Amended and Restated Articles of Incorporation  votes was
sufficient  for  approval.  From this date  forward  these  Amended and Restated
Articles of Incorporation shall supersede the original Articles of Incorporation
and all amendments and supplements thereto.  These Amended and Restated Articles
of  Incorporation  correctly  set  forth  the  provisions  of  the  Articles  of
Incorporation, as amended.


                                    ARTICLE I

                                      NAME
                                      ----

     The name of the corporation shall be Immune Response, Inc.


                                   ARTICLE II

                                    DURATION
                                    --------

     The period of duration of the Corporation shall be perpetual.


                                   ARTICLE III

                                  (ELIMINATED)
                                  ------------


                                   ARTICLE IV

                               PURPOSE AND POWERS
                               ------------------

     The purpose for which this  Corporation  is  organized  is to transact  any
lawful  business  or  businesses  for  which  corporations  may be  incorporated
pursuant  to the  Colorado  Business  Corporation  Act.  In  furtherance  of the
foregoing  purpose,  this Corporation shall have and may exercise any and all of
the powers now or hereafter conferred upon corporations incorporated pursuant to
the Colorado Business Corporation Act.


                                       -1-

<PAGE>

                                    ARTICLE V

                                  CAPITAL STOCK
                                  -------------

     The aggregate number of shares and the amount of total  authorized  capital
of the Company  shall consist of  950,000,000  shares of $.0001 par value common
stock.

     As  of  the  date  upon  which  these  Amended  and  Restated  Articles  of
Incorporation become effective,  each 100 shares of authorized $.0001 par common
stock, whether or not issued and outstanding,  shall be converted into one share
of $.0001 par common stock.  Fractional  shares resulting from the Reverse Stock
Split will be rounded to the closest whole share of Common Stock. Following this
reverse  stock  split the number of shares of $.0001 par common  stock which the
Company shall be authorized to issue shall be 25,000,000.

     The  holders  of  Common  Stock  shall  have  and  possess  all  rights  as
shareholders of the corporation.

     The capital stock, after the amount of the subscription price has been paid
in, shall not be subject to assessment  or any other  liability to pay the debts
of the corporation.

     Any stock of the  corporation may be issued for money,  property,  services
rendered, labor done, cash advances for the corporation, for any other assets of
value in  accordance  with  the  action  of the  Board  of  Directors,  or other
consideration  permitted  under  the  Colorado  Business  Corporation  Act.  The
judgment  of the Board of  Directors  as to value  received  in  return  for the
issuance of shares shall be conclusive  and said shares,  when issued,  shall be
fully paid and nonassessable.


                                   ARTICLE VI

                                CUMULATIVE VOTING
                                -----------------

     The Shareholders shall not be entitled to cumulative voting.


                                   ARTICLE VII

                                PREEMPTIVE RIGHTS
                                -----------------

     No holder of any stock of the Corporation shall be entitled, as a matter of
right,  to purchase,  subscribe  for or otherwise  acquire any new or additional
shares of stock of the  Corporation of any class,  or any options or warrants to
purchase,  subscribe for or otherwise acquire any such new or additional shares,
or  any shares, bonds, notes, debentures or other securities convertible into or

                                       -2-

<PAGE>

carrying options or warrants to purchase, subscribe for or otherwise acquire any
such new or additional shares.


                                  ARTICLE VIII

                           SHARE TRANSFER RESTRICTIONS
                           ---------------------------

     This  Corporation  shall  have the  right to impose  restrictions  upon the
transfer of any of its authorized shares or any interest  therein.  The Board of
Directors is hereby  authorized on behalf of this  Corporation  to exercise this
Corporation's right to so impose such restrictions.


                                   ARTICLE IX

                                  (ELIMINATED)
                                  ------------


                                    ARTICLE X

                               BOARD OF DIRECTORS
                               ------------------

     The number of Directors shall be fixed in accordance with the Bylaws.


                                   ARTICLE XI

                               AMENDMENT OF BYLAWS
                               -------------------

     In  furtherance  and not in limitation of the powers  conferred by statute,
the Board of  Directors  is expressly  authorized  to make,  alter or repeal the
Bylaws of the Corporation.


                                   ARTICLE XII

                              ELECTION OF DIRECTORS
                              ---------------------

     Election of Directors  need not be by written  ballot  unless the Bylaws of
the Corporation shall so provide.




                                       -3-

<PAGE>

                                  ARTICLE XIII

                          INDEMNIFICATION OF DIRECTORS
                   OFFICERS, EMPLOYEES, FIDUCIARIES AND AGENTS
                   -------------------------------------------

     To the fullest extent provided by applicable state law, including,  but not
limited to, the Colorado  Business  Corporation  Act,  each  director,  officer,
employee,  fiduciary or agent of the Corporation  (and his heirs,  executors and
administrators)  shall  be  indemnified  by  the  Corporation  against  expenses
reasonably  incurred by or imposed upon him in connection with or arising out of
any action, suit or proceeding in which he may be involved or to which he may be
made a party  by  reason  of his  being  or  having  been a  director,  officer,
employee,  fiduciary or agent of the Corporation, or at its request of any other
corporation  of which it is a  shareholder  or creditor and from which he is not
entitled  to be  indemnified  (whether  or not he  continues  to be a  director,
officer, employee,  fiduciary or agent at the time of imposing or incurring such
expenses).  The  foregoing  right of  indemnification  shall not be exclusive of
other rights to which he may be entitled under applicable state law.


                                   ARTICLE XIV

                            LIMITATIONS OF LIABILITY
                            ------------------------

     A  director  of the  Corporation  shall  not be  personally  liable  to the
Corporation  or its  Shareholders  for monetary  damages for breach of fiduciary
duty as a director;  except that this provision shall not eliminate or limit the
liability  of a director to the  Corporation  or its  Shareholders  for monetary
damages otherwise  existing for (i) any breach of the director's duty of loyalty
to the Corporation or its Shareholders; (ii) acts or omissions not in good faith
or which involve  intentional  misconduct or a knowing  violation of law;  (iii)
acts specified in Section 7-108-403 of the Colorado Business Corporation Act; or
(iv) any transaction from which the director directly or indirectly  derived any
improper personal benefit. If the Colorado Business Corporation Act is hereafter
amended to eliminate or limit  further the  liability  of a director,  then,  in
addition  to  the  elimination  and  limitation  of  liability  provided  by the
preceding  sentence,  the  liability of each  director  shall be  eliminated  or
limited to the fullest extent permitted by the Colorado Business Corporation Act
as  so  amended.  Any  repeal  or  modification  of  this  Article  XIV  by  the
Shareholders  of the  Corporation  shall  not  adversely  affect  any  right  or
protection of a director of the Corporation under this Article XIV, as in effect
immediately  prior to the repeal or modification,  with respect to any liability
that  would  have  accrued,  but for this  Article  XIV,  prior to the repeal or
modification.

                                       -4-

<PAGE>

     On behalf of IMMUNE RESPONSE,  INC., the  undersigned,  by their signatures
below, do hereby confirm, under penalties of perjury, that the foregoing Amended
and Restated Articles of Incorporation of IMMUNE RESPONSE,  INC.  constitute the
act and deed of IMMUNE RESPONSE, INC. and the facts stated herein are true.


                                       IMMUNE RESPONSE, INC.




                                       By___________________________
                                         Joseph W. Hovorka, President

[SEAL]




By______________________________
  Thomas B. Olson, Secretary

                                       -5-



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