IMMUNE RESPONSE INC
8-K, 1999-11-02
NON-OPERATING ESTABLISHMENTS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 8-K

                    Current Report Pursuant to Section 13 or
                       15(d) of The Securities Act of 1934



                Date of Report (Date of earliest event reported):
                       November 2, 1999 (November 2, 1999)



                              IMMUNE RESPONSE, INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)


COLORADO                          33-17922-C                          84-0950197
- --------------------------------------------------------------------------------
(State or other                   (Commission                   (I.R.S. Employer
jurisdiction                     File Number)               Identification No.)
of incorporation)




                            7315 East Peakview Avenue
                            Englewood, Colorado 80111
                ------------------------------------------------
               (Address of principal executive offices)(Zip Code)


       Registrant's telephone number, including area code: (303) 796-8139





         (Former name or former address, if changed since last report.)


<PAGE>

ITEM 4.  CHANGE IN REGISTRANT'S CERTIFYING ACCOUNTANT.

     (a) On November 2, 1999, Immune Response, Inc. (the "Registrant") dismissed
Davis & Co., CPA's, P.C. as its independent  certified public accountant.  There
have been no adverse  opinions,  disclaimers  of opinion  or  qualifications  or
modifications as to audit scope or accounting  principles  regarding the reports
of Davis & Co., CPA's, P.C. on the Registrant's financial statements for each of
the fiscal years ended  December 31, 1998 and 1997,  or any  subsequent  interim
period.  The Registrant's  Board of Directors approved the change of accountants
and that action was ratified by the Board of Directors of the  Registrant  as it
has no formal audit  committee.  There were no  disagreements  with Davis & Co.,
CPA's,  P.C. on any matter of  accounting  principles  or  practices,  financial
statement  disclosure,   or  auditing  scope  or  procedures  leading  to  their
dismissal.

     For the fiscal years ended December 31, 1998 and 1997, the auditors  report
contained a qualification  as to uncertainty  which read as follows for the year
ended December 31, 1998:

     "The accompanying financial statements have been prepared assuming that the
Company will  continue as a going  concern.  As discussed in Note 8, the Company
has minimal capital  resources  presently  available to meet  obligations  which
normally  can be  expected  to be  incurred  by  similar  companies,  and has an
accumulated  deficit of  ($924,145)  at December 31, 1998.  These  factors raise
substantial  doubt about the Company's  ability to continue as a going  concern.
Management's  plans in regard to these matters are also described in Note 8. The
financial  statements do not include any adjustments  that might result from the
outcome of this uncertainty."

     There  were no  reportable  events,  in each  case,  during  either  of the
Registrant's two most recent fiscal years or any subsequent interim period.

     (b)  Simultaneously  with the  dismissal  of its  former  accountants,  the
Registrant approved and engaged Gelfond Hochstadt  Pangburn,  P.C. to act as its
independent certified public accountant as successor to Davis & Co., CPA's, P.C.
During the  Registrant's  two most recent  fiscal  years or  subsequent  interim
periods the  Registrant  has not  consulted  Gelfond  Hochstadt  Pangburn,  P.C.
regarding the application of accounting  principles to a specified  transaction,
either  completed  or  proposed;  or the type of  audit  opinion  that  might be
rendered on the Registrant's  financial  statements,  or any matter that was the
subject of a disagreement or a reportable event.

ITEM 7.   FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS

(c)  EXHIBITS

     16.1      Letter from Davis & Co., CPA's, P.C. dated November 2, 1999,
               addressed to the Securities and Exchange Commission.

                                      -1-
<PAGE>

                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                       IMMUNE RESPONSE, INC.



Date: November 2, 1999                 By: /s/ Joseph W. Hovorka
                                           ----------------------------
                                           Joseph W. Hovorka, President


                                       -2-


                    [Letterhead - Davis & Co., CPA's, P.C.]

November 2, 1999


Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C. 20549


     Re:            Immune Response, Inc.
     SEC File No.:  33-17922-C


Ladies and Gentlemen:

Relative to the change in auditors,  we have read the statements  made by Immune
Response,  Inc. We  understand  that these  statements  are being filed with the
Commission,  pursuant to Item 4 of the Company's  Form 8-K report dated November
2, 1999. We agree with the statements concerning our firm in such Form 8-K.

Sincerely,

DAVIS & CO., CPA's, P.C.


/s/ Carol A. Davis
Carol A. Davis
Certified Public Accountant

cc:  Immune Response, Inc. - Joseph W. Hovorka



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